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24 results on '"Geurts-Moespot, Anneke J"'

6. Malaria early in the first pregnancy: Potential impact of iron status

Author

Diallo, Salou, primary, Roberts, Stephen A., additional, Gies, Sabine, additional, Rouamba, Toussaint, additional, Swinkels, Dorine W., additional, Geurts-Moespot, Anneke J., additional, Ouedraogo, Sayouba, additional, Ouedraogo, Georges Anicet, additional, Tinto, Halidou, additional, and Brabin, Bernard J., additional

Published
2020
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9. Malaria early in the first pregnancy: Potential impact of iron status.

Author

Diallo, Salou, Roberts, Stephen A, Gies, Sabine, Rouamba, Toussaint, Swinkels, Dorine DW, Geurts-Moespot, Anneke J, Ouedraogo, Sayouba, Ouedraogo, Georges Anicet, Tinto, Halidou, Brabin, Bernard BJ, Diallo, Salou, Roberts, Stephen A, Gies, Sabine, Rouamba, Toussaint, Swinkels, Dorine DW, Geurts-Moespot, Anneke J, Ouedraogo, Sayouba, Ouedraogo, Georges Anicet, Tinto, Halidou, and Brabin, Bernard BJ

Abstract

Low iron stores may protect from malaria infection, therefore improving iron stores in early pregnancy in line with current recommendations could increase malaria susceptibility. To test this hypothesis we compared iron biomarkers and red cell indices in nulliparae and primigravidae who participated in a randomized controlled trial of long-term weekly iron supplementation., info:eu-repo/semantics/published

Published
2019

10. Provisional standardization of hepcidin assays: creating a traceability chain with a primary reference material, candidate reference method and a commutable secondary reference material

Author

Diepeveen, Laura E., primary, Laarakkers, Coby M.M., additional, Martos, Gustavo, additional, Pawlak, Marta E., additional, Uğuz, Fatih F., additional, Verberne, Kim E.S.A., additional, van Swelm, Rachel P.L., additional, Klaver, Siem, additional, de Haan, Anton F.J., additional, Pitts, Kelly R., additional, Bansal, Sukhvinder S., additional, Abbas, Ioana M., additional, Fillet, Marianne, additional, Lefebvre, Thibaud, additional, Geurts-Moespot, Anneke J., additional, Girelli, Domenico, additional, Castagna, Annalisa, additional, Herkert, Matthias, additional, Itkonen, Outi, additional, Olbina, Gordana, additional, Tomosugi, Naohisa, additional, Westerman, Mark E., additional, Delatour, Vincent, additional, Weykamp, Cas W., additional, and Swinkels, Dorine W., additional

Published
2018
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12. The macrophage migration inhibitory factor pathway in human B cells is tightly controlled and dysregulated in multiple sclerosis

Author

Rijvers, Liza, primary, Melief, Marie-José, additional, van der Vuurst de Vries, Roos M., additional, Stéphant, Maeva, additional, van Langelaar, Jamie, additional, Wierenga-Wolf, Annet F., additional, Hogervorst, Jeanet M., additional, Geurts-Moespot, Anneke J., additional, Sweep, Fred C. G. J., additional, Hintzen, Rogier Q., additional, and van Luijn, Marvin M., additional

Published
2018
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14. Meta-GWAS and Meta-Analysis of Exome Array Studies Do Not Reveal Genetic Determinants of Serum Hepcidin

Author

Galesloot, Tessel E., primary, Verweij, Niek, additional, Traglia, Michela, additional, Barbieri, Caterina, additional, van Dijk, Freerk, additional, Geurts-Moespot, Anneke J., additional, Girelli, Domenico, additional, Kiemeney, Lambertus A. L. M., additional, Sweep, Fred C. G. J., additional, Swertz, Morris A., additional, van der Meer, Peter, additional, Camaschella, Clara, additional, Toniolo, Daniela, additional, Vermeulen, Sita H., additional, van der Harst, Pim, additional, and Swinkels, Dorine W., additional

Published
2016
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15. Provisional standardization of hepcidin assays: creating a traceability chain with a primary reference material, candidate reference method and a commutable secondary reference material.

Author

Diepeveen, Laura E., Laarakkers, Coby M.M., Martos, Gustavo, Pawlak, Marta E., Uğuz, Fatih F., Verberne, Kim E.S.A., van Swelm, Rachel P.L., Klaver, Siem, de Haan, Anton F.J., Pitts, Kelly R., Bansal, Sukhvinder S., Abbas, Ioana M., Fillet, Marianne, Lefebvre, Thibaud, Geurts-Moespot, Anneke J., Girelli, Domenico, Castagna, Annalisa, Herkert, Matthias, Itkonen, Outi, and Olbina, Gordana

Subjects
HEPCIDIN, IRON metabolism, ISOTOPE dilution analysis, MASS spectrometry, PATHOLOGICAL laboratories
Abstract

Background: Hepcidin concentrations measured by various methods differ considerably, complicating interpretation. Here, a previously identified plasma-based candidate secondary reference material (csRM) was modified into a serum-based two-leveled sRM. We validated its functionality to increase the equivalence between methods for international standardization. Methods: We applied technical procedures developed by the International Consortium for Harmonization of Clinical Laboratory Results. The sRM, consisting of lyophilized serum with cryolyoprotectant, appeared commutable among nine different measurement procedures using 16 native human serum samples in a first round robin (RR1). Harmonization potential of the sRM was simulated in RR1 and evaluated in practice in RR2 among 11 measurement procedures using three native human plasma samples. Comprehensive purity analysis of a candidate primary RM (cpRM) was performed by state of the art procedures. The sRM was value assigned with an isotope dilution mass spectrometry-based candidate reference method calibrated using the certified pRM. Results: The inter-assay CV without harmonization was 42.1% and 52.8% in RR1 and RR2, respectively. In RR1, simulation of harmonization with sRM resulted in an inter-assay CV of 11.0%, whereas in RR2 calibration with the material resulted in an inter-assay CV of 19.1%. Both the sRM and pRM passed international homogeneity criteria and showed long-term stability. We assigned values to the low (0.95±0.11 nmol/L) and middle concentration (3.75±0.17 nmol/L) calibrators of the sRM. Conclusions: Standardization of hepcidin is possible with our sRM, which value is assigned by a pRM. We propose the implementation of this material as an international calibrator for hepcidin. [ABSTRACT FROM AUTHOR]

Published
2019
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16. Toward Worldwide Hepcidin Assay Harmonization: Identification of a Commutable Secondary Reference Material

Author

van der Vorm, Lisa N, primary, Hendriks, Jan C M, primary, Laarakkers, Coby M, primary, Klaver, Siem, primary, Armitage, Andrew E, primary, Bamberg, Alison, primary, Geurts-Moespot, Anneke J, primary, Girelli, Domenico, primary, Herkert, Matthias, primary, Itkonen, Outi, primary, Konrad, Robert J, primary, Tomosugi, Naohisa, primary, Westerman, Mark, primary, Bansal, Sukhvinder S, primary, Campostrini, Natascia, primary, Drakesmith, Hal, primary, Fillet, Marianne, primary, Olbina, Gordana, primary, Pasricha, Sant-Rayn, primary, Pitts, Kelly R, primary, Sloan, John H, primary, Tagliaro, Franco, primary, Weykamp, Cas W, primary, and Swinkels, Dorine W, primary

Published
2016
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21. Immunochemical and Mass-Spectrometry–Based Serum Hepcidin Assays for Iron Metabolism Disorders

Author

Kroot, Joyce JC, primary, Laarakkers, Coby MM, primary, Geurts-Moespot, Anneke J, primary, Grebenchtchikov, Nicolaï, primary, Pickkers, Peter, primary, van Ede, Annelies E, primary, Peters, Hilde PE, primary, van Dongen-Lases, Edmée, primary, Wetzels, Jack FM, primary, Sweep, Fred CGJ, primary, Tjalsma, Harold, primary, and Swinkels, Dorine W, primary

Published
2010
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23. Meta-GWAS and Meta-Analysis of Exome Array Studies Do Not Reveal Genetic Determinants of Serum Hepcidin

Author

Lambertus A. Kiemeney, Caterina Barbieri, Niek Verweij, Clara Camaschella, Freerk van Dijk, Domenico Girelli, Pim Der Van Harst, Peter Der Van Meer, Dorine W. Swinkels, Sita H. Vermeulen, Tessel E. Galesloot, Morris A. Swertz, Anneke Geurts-Moespot, Fred C.G.J. Sweep, Daniela Toniolo, Michela Traglia, Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Cardiovascular Centre (CVC), Restoring Organ Function by Means of Regenerative Medicine (REGENERATE), Galesloot, Tessel E., Verweij, Niek, Traglia, Michela, Barbieri, Caterina, Van Dijk, Freerk, Geurts Moespot, Anneke J., Girelli, Domenico, Kiemeney, Lambertus A. L. M., Sweep, Fred C. G. J., Swertz, Morris A., Van Meer, Peter Der, Camaschella, Clara, Toniolo, Daniela, Vermeulen, Sita H., Van Harst, Pim Der, and Swinkels, Dorine W.

Subjects
Male, 0301 basic medicine, HOMEOSTASIS, Heredity, HEMOCHROMATOSIS, lcsh:Medicine, Genome-wide association study, Mathematical and Statistical Techniques, Erythropoiesis, Exome, lcsh:Science, Genetics, GENERAL-POPULATION, RISK, Multidisciplinary, biology, Chromosome Biology, Medicine (all), COMMON VARIANTS, Genomics, BODY IRON STORES, Women's cancers Radboud Institute for Health Sciences [Radboudumc 17], Genetic Mapping, Urological cancers Radboud Institute for Health Sciences [Radboudumc 15], Physical Sciences, Female, Statistics (Mathematics), Research Article, Genotyping, TMPRSS6, Genotype, Iron, Variant Genotypes, Research and Analysis Methods, Polymorphism, Single Nucleotide, Chromosomes, Genetic determinism, Genetic Determinism, 03 medical and health sciences, Hepcidins, Hepcidin, Genome-Wide Association Studies, Humans, Genetic Predisposition to Disease, Statistical Methods, 1000 Genomes Project, Allele, GENOME-WIDE ASSOCIATION, Molecular Biology Techniques, Molecular Biology, Alleles, Inflammation, Biochemistry, Genetics and Molecular Biology (all), lcsh:R, Biology and Life Sciences, Computational Biology, nutritional and metabolic diseases, Human Genetics, Chromosome 2, Cell Biology, MASS-SPECTROMETRY, Genome Analysis, Chromosome Pairs, Renal disorders Radboud Institute for Molecular Life Sciences [Radboudumc 11], 030104 developmental biology, Agricultural and Biological Sciences (all), Genetic Loci, biology.protein, lcsh:Q, hepcidin, HFE, Mathematics, Imputation (genetics), Genome-Wide Association Study, Meta-Analysis
Abstract

Contains fulltext : 170964.pdf (Publisher’s version ) (Open Access) Serum hepcidin concentration is regulated by iron status, inflammation, erythropoiesis and numerous other factors, but underlying processes are incompletely understood. We studied the association of common and rare single nucleotide variants (SNVs) with serum hepcidin in one Italian study and two large Dutch population-based studies. We genotyped common SNVs with genome-wide association study (GWAS) arrays and subsequently performed imputation using the 1000 Genomes reference panel. Cohort-specific GWAS were performed for log-transformed serum hepcidin, adjusted for age and gender, and results were combined in a fixed-effects meta-analysis (total N 6,096). Six top SNVs (p

Published
2016

24. The complex between urokinase-type plasminogen activator (uPA) and its type-1 inhibitor (PAI-I) independently predicts response to first-line endocrine therapy in advanced breast cancer.

Author

Manders P, Tjan-Heijnen VC, Span PN, Grebenchtchikov N, Geurts-Moespot AJ, van Tienoven DT, Beex LV, and Sweep FC

Subjects
Adult, Aged, Aged, 80 and over, Breast Neoplasms diagnosis, Cytosol metabolism, Disease Progression, Disease-Free Survival, Endocrine System embryology, Enzyme-Linked Immunosorbent Assay, Female, Humans, Lymphatic Metastasis, Middle Aged, Multivariate Analysis, Odds Ratio, Plasminogen Activator Inhibitor 1 chemistry, Protein Binding, Time Factors, Treatment Outcome, Urokinase-Type Plasminogen Activator chemistry, Breast Neoplasms metabolism, Breast Neoplasms therapy, Plasminogen Activator Inhibitor 1 metabolism, Urokinase-Type Plasminogen Activator metabolism
Abstract

It has been shown that urokinase-type plasminogen activator (uPA) and its main inhibitor (PAI-I) have predictive value for therapy success in advanced breast cancer. Levels of the complex between uPA and PAI-I, formed when both molecules are in their active form, might have superior predictive power. Here, we investigate the association between levels of uPA:PAI-I complex and rate of response to first-line systemic therapy for advanced breast cancer. Tumor tissues of 170 patients with advanced breast cancer were analyzed for uPA:PAI-I complex concentrations using a quantitative enzyme-linked immunosorbent assay. The patients received either endocrine therapy (n=96) or chemotherapy (n=74) as first-line treatment after diagnosis of advanced disease. Of the endocrine treated patients, those with high levels of uPA:PAI-I complex showed a shorter progression-free survival (PFS) compared to patients with lower uPA:PAI-I complex levels (P=0.035). Furthermore, in the multivariate regression analysis a significant lower rate of response to first-line endocrine therapy was found in patients with high uPA:PAI-I complex levels compared to patients with low uPA:PAI-I complex levels (odds ratio (OR)=0.27, 95% CI, 0.09-0.59, P=0.018), in addition to the predictive impact of the steroid hormone receptor (ER/PgR) status (OR=2.68, 95% CI, 1.08-6.63, P=0.033). Complex levels did not predict efficacy of chemotherapy in patients with advanced breast cancer. The results show that the plasminogen activation system affects the response to endocrine therapy independent of steroid hormone receptor status and may be of help to further refine the indication for this treatment in individual patients. Further studies are warranted to explain this underlying resistance to endocrine therapy when uPA:PAI-I levels are high.

Published
2004
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