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2. Erectile function preservation after salvage radiation therapy for biochemically recurrent prostate cancer after prostatectomy: Five-year results of the SAKK 09/10 randomized phase 3 trial

Author

Zwahlen, Daniel R., Schröder, Christina, Holer, Lisa, Bernhard, Jürg, Hölscher, Tobias, Arnold, Winfried, Polat, Bülent, Hildebrandt, Guido, Müller, Arndt-Christian, Martin Putora, Paul, Papachristofilou, Alexandros, Schär, Corinne, Hayoz, Stefanie, Sumila, Marcin, Zaugg, Kathrin, Guckenberger, Matthias, Ost, Piet, Giovanni Bosetti, Davide, Reuter, Christiane, Gomez, Silvia, Khanfir, Kaouthar, Beck, Marcus, Thalmann, George N., Aebersold, Daniel M., and Ghadjar, Pirus

Published
2024
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4. A patterns of care analysis of hyperthermia in combination with radio(chemo)therapy or chemotherapy in European clinical centers

Author

Ademaj, Adela, Veltsista, Paraskevi D., Marder, Dietmar, Hälg, Roger A., Puric, Emsad, Brunner, Thomas B., Crezee, Hans, Gabrys, Dorota, Franckena, Martine, Gani, Cihan, Horsman, Michael R., Krempien, Robert, Lindner, Lars H., Maluta, Sergio, Notter, Markus, Petzold, Griseldis, Abdel-Rahman, Sultan, Richetti, Antonella, Thomsen, Andreas R., Tsoutsou, Pelagia, Fietkau, Rainer, Ott, Oliver J., Ghadjar, Pirus, and Riesterer, Oliver

Published
2023
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6. Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): An update on 107 randomized trials and 19,805 patients, on behalf of MACH-NC Group

Author

Lacas, Benjamin, Carmel, Alexandra, Landais, Cécile, Wong, Stuart J, Licitra, Lisa, Tobias, Jeffrey S, Burtness, Barbara, Ghi, Maria Grazia, Cohen, Ezra EW, Grau, Cai, Wolf, Gregory, Hitt, Ricardo, Corvò, Renzo, Budach, Volker, Kumar, Shaleen, Laskar, Sarbani Ghosh, Mazeron, Jean-Jacques, Zhong, Lai-Ping, Dobrowsky, Werner, Ghadjar, Pirus, Fallai, Carlo, Zakotnik, Branko, Sharma, Atul, Bensadoun, René-Jean, Redda, Maria Grazia Ruo, Racadot, Séverine, Fountzilas, George, Brizel, David, Rovea, Paolo, Argiris, Athanassios, Nagy, Zoltán Takácsi, Lee, Ju-Whei, Fortpied, Catherine, Harris, Jonathan, Bourhis, Jean, Aupérin, Anne, Blanchard, Pierre, Pignon, Jean-Pierre, Group, MACH-NC Collaborative, Adelstein, DJ, Alfonsi, M, Belkacemi, Y, Bar-Ad, V, Bernier, J, Bratland, Å, Calais, G, Campbell, B, Caudell, J, Chabaud, S, Chamorey, E, Chaukar, D, Choi, KN, Choussy, O, Collette, L, Cruz, JJ, Dani, C, Dauzier, E, Forastiere, AA, Garaud, P, Gregoire, V, Hackshaw, A, Haddad, E, Haffty, BG, Hansen, A, Hayoz, S, Horiot, JC, Jeremic, B, Karrison, TG, Langendijk, JA, Lapeyre, M, Lartigau, E, Leong, T, Le, QT, Lee, PPY, Lewin, F, Lin, A, Lopes, A, Mehta, S, Moon, J, Moyal, E, Occéan, BV, Olmi, P, Orecchia, R, O'Sullivan, B, Overgaard, J, Petit, C, Quon, H, Sanguineti, G, Satar, T, Simes, J, Simon, C, Sire, C, Staar, S, Stromberger, C, Strojan, P, Temam, S, Thomson, D, Timochenko, A, Torri, V, and Tseroni, V

Subjects
Cancer, Clinical Trials and Supportive Activities, Rare Diseases, Clinical Research, 6.5 Radiotherapy and other non-invasive therapies, Evaluation of treatments and therapeutic interventions, Antineoplastic Combined Chemotherapy Protocols, Carcinoma, Squamous Cell, Chemotherapy, Adjuvant, Head and Neck Neoplasms, Humans, Induction Chemotherapy, Randomized Controlled Trials as Topic, Meta-analysis, Review, Individual Patient Data, Randomised Clinical Trials, Chemotherapy, Radiotherapy, Head and Neck Cancer, MACH-NC Collaborative Group, Other Physical Sciences, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

Background and purposeThe Meta-Analysis of Chemotherapy in squamous cell Head and Neck Cancer (MACH-NC) demonstrated that concomitant chemotherapy (CT) improved overall survival (OS) in patients without distant metastasis. We report the updated results.Materials and methodsPublished or unpublished randomized trials including patients with non-metastatic carcinoma randomized between 1965 and 2016 and comparing curative loco-regional treatment (LRT) to LRT + CT or adding another timing of CT to LRT + CT (main question), or comparing induction CT + radiotherapy to radiotherapy + concomitant (or alternating) CT (secondary question) were eligible. Individual patient data were collected and combined using a fixed-effect model. OS was the main endpoint.ResultsFor the main question, 101 trials (18951 patients, median follow-up of 6.5 years) were analyzed. For both questions, there were 16 new (2767 patients) and 11 updated trials. Around 90% of the patients had stage III or IV disease. Interaction between treatment effect on OS and the timing of CT was significant (p

Published
2021

9. Genomic Classifiers in Personalized Prostate Cancer Radiation Therapy Approaches: A Systematic Review and Future Perspectives Based on International Consensus

Author

Spohn, Simon K.B., Draulans, Cédric, Kishan, Amar U., Spratt, Daniel, Ross, Ashley, Maurer, Tobias, Tilki, Derya, Berlin, Alejandro, Blanchard, Pierre, Collins, Sean, Bronsert, Peter, Chen, Ronald, Pra, Alan Dal, de Meerleer, Gert, Eade, Thomas, Haustermans, Karin, Hölscher, Tobias, Höcht, Stefan, Ghadjar, Pirus, Davicioni, Elai, Heck, Matthias, Kerkmeijer, Linda G.W., Kirste, Simon, Tselis, Nikolaos, Tran, Phuoc T., Pinkawa, Michael, Pommier, Pascal, Deltas, Constantinos, Schmidt-Hegemann, Nina-Sophie, Wiegel, Thomas, Zilli, Thomas, Tree, Alison C., Qiu, Xuefeng, Murthy, Vedang, Epstein, Jonathan I., Graztke, Christian, Gao, Xin, Grosu, Anca L., Kamran, Sophia C., and Zamboglou, Constantinos

Published
2023
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10. Regional hyperthermia with cisplatin added to gemcitabine versus gemcitabine in patients with resected pancreatic ductal adenocarcinoma: The HEAT randomised clinical trial

Author

Issels, Rolf D., Boeck, Stefan, Pelzer, Uwe, Mansmann, Ulrich, Ghadjar, Pirus, Lindner, Lars H., Albertsmeier, Markus, Angele, Martin K., Schmidt, Michael, Xu, Yujun, Bahra, Marcus, Pratschke, Johann, Schoenberg, Michael, Thasler, Wolfgang E., Salat, Christoph, Stoetzer, Oliver J., Knoefel, Wolfram T., Graf, Dirk, Wessalowski, Rüdiger, Keitel-Anselmino, Verena, Koenigsrainer, Alfred, Bitzer, Michael, Zips, Daniel, Bamberg, Michael, Fietkau, Rainer, Ott, Oliver, Kawecki, Maciej, Wyrwicz, Lucjan, Rutkowski, Piotr, Rentsch, Markus, Ababei, Juliana, Reichardt, Peter, Rigamonti, Marco, Weber, Bernhard, Abdel-Rahman, Sultan, Tschoep–Lechner, Katharina, Jauch, Karl-Walter, Bruns, Christiane J., Oettle, Helmut, von Bergwelt-Baildon, Michael, Heinemann, Volker, and Werner, Jens

Published
2023
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12. PSMA-PET- and MRI-Based Focal Dose Escalated Radiation Therapy of Primary Prostate Cancer: Planned Safety Analysis of a Nonrandomized 2-Armed Phase 2 Trial (ARO2020-01)

Author

Zamboglou, Constantinos, Spohn, Simon K.B., Ruf, Juri, Benndorf, Matthias, Gainey, Mark, Kamps, Marius, Jilg, Cordula, Gratzke, Christian, Adebahr, Sonja, Schmidtmayer-Zamboglou, Barbara, Mix, Michael, Bamberg, Fabian, Zschaeck, Sebastian, Ghadjar, Pirus, Baltas, Dimos, and Grosu, Anca L.

Published
2022
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13. Adherence to Contouring and Treatment Planning Requirements Within a Multicentric Trial: Results of the Quality Assurance of the SAKK 09/10 trial

Author

Beck, Marcus, Sassowsky, Manfred, Schär, Sämi, Mathier, Etienne, Halter, Matthias, Zwahlen, Daniel R., Hölscher, Tobias, Arnold, Winfried, Polat, Bülent, Hildebrandt, Guido, Müller, Arndt-Christian, Putora, Paul M., Papachristofilou, Alexandros, Hayoz, Stefanie, Schär, Corinne, Li, Qiyu, Sumila, Marcin, Zaugg, Kathrin, Guckenberger, Matthias, Ost, Piet, Bosetti, Davide G., Reuter, Christiane, Gomez, Silvia, Khanfir, Kaouthar, Aebersold, Daniel M., Ghadjar, Pirus, and Pra, Alan Dal

Published
2022
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16. Moderately hypofractionated radiotherapy as definitive treatment for localized prostate cancer: Pattern of practice in German-speaking countries: A survey of the Prostate Cancer Expert Panel of the German Society of Radiation Oncology (DEGRO) and the Working Party on Radiation Oncology of the German Cancer Society (DKG-ARO)

Author

Shelan, Mohamed, Aebersold, Daniel M., Albrecht, Clemens, Böhmer, Dirk, Flentje, Michael, Ganswindt, Ute, Höcht, Stefan, Hölscher, Tobias, Müller, Arndt-Christian, Niehoff, Peter, Pinkawa, Michael, Schmidt-Hegemann, Nina-Sophie, Sedlmayer, Felix, Wolf, Frank, Zamboglou, Constantinos, Zips, Daniel, Wiegel, Thomas, and Ghadjar, Pirus

Published
2021
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17. Regional hyperthermia for soft tissue sarcoma – a survey on current practice, controversies and consensus among 12 European centers

Author

Roohani, Siyer, primary, Ehret, Felix, additional, Beck, Marcus, additional, Veltsista, Danai P., additional, Nadobny, Jacek, additional, Zschaeck, Sebastian, additional, Abdel-Rahman, Sultan, additional, Eckert, Franziska, additional, Flörcken, Anne, additional, Issels, Rolf D., additional, Klöck, Stephan, additional, Krempien, Robert, additional, Lindner, Lars H., additional, Notter, Markus, additional, Ott, Oliver J., additional, Pink, Daniel, additional, Potkrajcic, Vlatko, additional, Reichardt, Peter, additional, Riesterer, Oliver, additional, Spałek, Mateusz Jacek, additional, Stutz, Emanuel, additional, Wessalowski, Rüdiger, additional, Zilli, Thomas, additional, Zips, Daniel, additional, Ghadjar, Pirus, additional, and Kaul, David, additional

Published
2024
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18. Recommendations for postoperative radiotherapy in head & neck squamous cell carcinoma in the presence of flaps: A GORTEC internationally-reviewed HNCIG-endorsed consensus

Author

Carsuzaa, Florent, Lapeyre, Michel, Gregoire, Vincent, Maingon, Philippe, Beddok, Arnaud, Marcy, Pierre-Yves, Salleron, Julia, Coutte, Alexandre, Racadot, Severine, Pointreau, Yoann, Graff, Pierre, Beadle, Beth, Benezery, Karen, Biau, Julian, Calugaru, Valentin, Castelli, Joel, Chua, Melvin, Di Rito, Alessia, Dore, Melanie, Ghadjar, Pirus, Huguet, Florence, Jardel, Pauline, Johansen, Jorgen, Kimple, Randall, Krengli, Marco, Laskar, Sarbani, Mcdowell, Lachlan, Nichols, Anthony, tribius, Silke, Valduvieco, Izaskun, Hu, Chaosu, Liem, Xavier, Moya-Plana, Antoine, D'onofrio, Ida, Parvathaneni, Upendra, Takiar, Vinita, Orlandi, Ester, Psyrri, Amanda, Shenouda, George, Sher, David, Steuer, Conor, Shan Sun, Xu, Tao, Yungan, Thomson, David, Tsai, Mu-Hung, Vulquin, Noemie, Gorphe, Philippe, Mehanna, Hisham, Yom, Sue S., Bourhis, Jean, and Thariat, Juliette

Published
2021
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20. Radiotherapy in nodal oligorecurrent prostate cancer

Author

Pinkawa, Michael, Aebersold, Daniel M., Böhmer, Dirk, Flentje, Michael, Ghadjar, Pirus, Schmidt-Hegemann, Nina-Sophie, Höcht, Stefan, Hölscher, Tobias, Müller, Arndt-Christian, Niehoff, Peter, Sedlmayer, Felix, Wolf, Frank, Zamboglou, Constantinos, Zips, Daniel, and Wiegel, Thomas

Published
2021
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23. Helmet Radio Frequency Phased Array Applicators Enhance Thermal Magnetic Resonance of Brain Tumors.

Author

Rahimi, Faezeh, Nurzed, Bilguun, Eigentler, Thomas W., Berangi, Mostafa, Oberacker, Eva, Kuehne, Andre, Ghadjar, Pirus, Millward, Jason M., Schuhmann, Rolf, and Niendorf, Thoralf

Subjects
BRAIN tumors, GLIOBLASTOMA multiforme, MAGNETIC resonance imaging, MAGNETIC resonance, ELECTROMAGNETIC fields
Abstract

Thermal Magnetic Resonance (ThermalMR) integrates Magnetic Resonance Imaging (MRI) diagnostics and targeted radio-frequency (RF) heating in a single theranostic device. The requirements for MRI (magnetic field) and targeted RF heating (electric field) govern the design of ThermalMR applicators. We hypothesize that helmet RF applicators (HPA) improve the efficacy of ThermalMR of brain tumors versus an annular phased RF array (APA). An HPA was designed using eight broadband self-grounded bow-tie (SGBT) antennae plus two SGBTs placed on top of the head. An APA of 10 equally spaced SGBTs was used as a reference. Electromagnetic field (EMF) simulations were performed for a test object (phantom) and a human head model. For a clinical scenario, the head model was modified with a tumor volume obtained from a patient with glioblastoma multiforme. To assess performance, we introduced multi-target evaluation (MTE) to ensure whole-brain slice accessibility. We implemented time multiplexed vector field shaping to optimize RF excitation. Our EMF and temperature simulations demonstrate that the HPA improves performance criteria critical to MRI and enhances targeted RF and temperature focusing versus the APA. Our findings are a foundation for the experimental implementation and application of a HPA en route to ThermalMR of brain tumors. [ABSTRACT FROM AUTHOR]

Published
2024
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24. 68Ga-labeled fibroblast activation protein inhibitor (FAPI) PET/CT for locally advanced or recurrent pancreatic cancer staging and restaging after chemoradiotherapy.

Author

Metzger, Giulia, Bayerl, Christian, Rogasch, Julian M. M., Furth, Christian, Wetz, Christoph, Beck, Marcus, Mehrhof, Felix, Amthauer, Holger, Ghadjar, Pirus, Neumann, Christopher, Pelzer, Uwe, Zips, Daniel, Hofheinz, Frank, Grabowski, Jane, Schatka, Imke, and Zschaeck, Sebastian

Published
2024
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32. Impact of dose intensified salvage radiation therapy on urinary continence recovery after radical prostatectomy: Results of the randomized trial SAKK 09/10

Author

Ghadjar, Pirus, Hayoz, Stefanie, Bernhard, Jürg, Zwahlen, Daniel R., Stein, Jürgen, Hölscher, Tobias, Gut, Philipp, Polat, Bülent, Hildebrandt, Guido, Müller, Arndt-Christian, Putora, Paul Martin, Papachristofilou, Alexandros, Schär, Corinne, Dal Pra, Alan, Biaggi Rudolf, Christine, Wust, Peter, Aebersold, Daniel M., and Thalmann, George N.

Published
2018
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34. Hyperthermia in the treatment of high-risk soft tissue sarcomas: a systematic review

Author

Veltsista, Paraskevi Danai, primary, Oberacker, Eva, additional, Ademaj, Adela, additional, Corradini, Stefanie, additional, Eckert, Franziska, additional, Flörcken, Anne, additional, Kaul, David, additional, Lindner, Lars H., additional, Issels, Rolf, additional, Ott, Oliver J., additional, Pink, Daniel, additional, Potkrajcic, Vlatko, additional, Reichardt, Peter, additional, Roohani, Siyer, additional, Spalek, Mateusz Jacek, additional, Riesterer, Oliver, additional, Zips, Daniel, additional, and Ghadjar, Pirus, additional

Published
2023
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37. Practice Patterns Compared with Evidence-based Strategies for the Management of Androgen Deprivation Therapy–Induced Side Effects in Prostate Cancer Patients: Results of a European Web-based Survey

Author

Bultijnck, Renée, Surcel, Cristian, Ploussard, Guillaume, Briganti, Alberto, De Visschere, Pieter, Fütterer, Jurgen, Ghadjar, Pirus, Giannarini, Gianluca, Isbarn, Hendrik, Massard, Christophe, Sooriakumaran, Prasanna, Valerio, Massimo, van den Bergh, Roderick, and Ost, Piet

Published
2016
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39. Salvage Radiotherapy After Radical Prostatectomy

Author

Papachristofilou, Alexandros, Ghadjar, Pirus, Zimmermann, Frank, Brady, Luther W., Series editor, Combs, Stephanie E., Series editor, Lu, Jiade J., Series editor, Geinitz, Hans, editor, Roach III, Mack, editor, and van As, Nicholas, editor

Published
2015
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41. Use of androgen deprivation and salvage radiation therapy for patients with prostate cancer and biochemical recurrence after prostatectomy

Author

Ghadjar, Pirus, Aebersold, Daniel M., Albrecht, Clemens, Böhmer, Dirk, Flentje, Michael, Ganswindt, Ute, Höcht, Stefan, Hölscher, Tobias, Sedlmayer, Felix, Wenz, Frederik, Zips, Daniel, Wiegel, Thomas, and Prostate Cancer Expert Panel of the German Society of Radiation Oncology (DEGRO) and the Working Party Radiation Oncology of the German Cancer Society (DKG-ARO)

Published
2018
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42. Radiofrequency applicator concepts for simultaneous MR imaging and hyperthermia treatment of glioblastoma multiforme

Author

Oberacker Eva, Kuehne Andre, Nadobny Jacek, Zschaeck Sebastian, Weihrauch Mirko, Waiczies Helmar, Ghadjar Pirus, Wust Peter, Niendorf Thoralf, and Winter Lukas

Subjects
thermal magnetic resonance, rf heating, hyperthermia, glioblastoma multiforme, rf applicator, Medicine
Abstract

Glioblastoma multiforme is the most frequent and most aggressive malignant brain tumor with de facto no long term curation by the use of current multimodal therapeutic approaches. The efficacy of brachytherapy and enhancing interstitial hyperthermia has been demonstrated. RF heating at ultrahigh fields (B0=7.0T, f=298MHz) has the potential of delivering sufficiently large thermal dosage for hyperthermia of relatively large tumor areas. This work focuses on electromagnetic field (EMF) simulations and provides realistic applicator designs tailored for simultaneous RF heating and MRI. Our simulations took advantage of target volumes derived from patient data, and our preliminary results suggest that RF power can be focused to both a small tumor area and a large clinical target volume.

Published
2017
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43. Phase 2, multicenter, randomized study of salvage radiation therapy +/- metformin for recurrent prostate cancer after radical prostatectomy (SAKK 08/15 – GETUG-AFU 34 PROMET trial).

Author

Dal Pra, Alan, primary, Supiot, Stephane, additional, Gysel, Katrin, additional, Zilli, Thomas, additional, Cathomas, Richard, additional, Reynaud, Thomas, additional, Pommier, Pascal, additional, Putora, Paul Martin, additional, Bosetti, Davide Giovanni, additional, Guckenberger, Matthias, additional, Hildebrandt, Guido, additional, Chiquet, Sabrina, additional, Brihoum, Meryem, additional, Papachristofilou, Alexandros, additional, Hayoz, Stefanie, additional, Ghadjar, Pirus, additional, Zwahlen, Daniel Rudolf, additional, Gillessen, Silke, additional, Omlin, Aurelius Gabriel, additional, and Aebersold, Daniel M., additional

Published
2023
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44. Genomic classifiers in personalized prostate cancer radiation therapy approaches: a systematic review and future perspectives based on international consensus

Author

Tilki, Derya, Spohn, Simon K.B.; Draulans, Cédric; Kishan, Amar U.; Spratt, Daniel; Ross, Ashley; Maurer, Tobias; Berlin, Alejandro; Blanchard, Pierre; Collins, Sean; Bronsert, Peter; Chen, Ronald; Pra, Alan Dal; de Meerleer, Gert; Eade, Thomas; Haustermans, Karin; Hölscher, Tobias; Höcht, Stefan; Ghadjar, Pirus; Davicioni, Elai; Heck, Matthias; Kerkmeijer, Linda G.W.; Kirste, Simon; Tselis, Nikolaos; Tran, Phuoc T.; Pinkawa, Michael; Pommier, Pascal; Deltas, Constantinos; Schmidt-Hegemann, Nina-Sophie; Wiegel, Thomas; Zilli, Thomas; Tree, Alison C.; Qiu, Xuefeng; Murthy, Vedang; Epstein, Jonathan I.; Graztke, Christian; Gao, Xin; Grosu, Anca L.; Kamran, Sophia C.; Zamboglou, Constantinos, Koç University Hospital, School of Medicine, Tilki, Derya, Spohn, Simon K.B.; Draulans, Cédric; Kishan, Amar U.; Spratt, Daniel; Ross, Ashley; Maurer, Tobias; Berlin, Alejandro; Blanchard, Pierre; Collins, Sean; Bronsert, Peter; Chen, Ronald; Pra, Alan Dal; de Meerleer, Gert; Eade, Thomas; Haustermans, Karin; Hölscher, Tobias; Höcht, Stefan; Ghadjar, Pirus; Davicioni, Elai; Heck, Matthias; Kerkmeijer, Linda G.W.; Kirste, Simon; Tselis, Nikolaos; Tran, Phuoc T.; Pinkawa, Michael; Pommier, Pascal; Deltas, Constantinos; Schmidt-Hegemann, Nina-Sophie; Wiegel, Thomas; Zilli, Thomas; Tree, Alison C.; Qiu, Xuefeng; Murthy, Vedang; Epstein, Jonathan I.; Graztke, Christian; Gao, Xin; Grosu, Anca L.; Kamran, Sophia C.; Zamboglou, Constantinos, Koç University Hospital, and School of Medicine

Abstract

Current risk-stratification systems for prostate cancer (PCa) do not sufficiently reflect the disease heterogeneity. Genomic classifiers (GC) enable improved risk stratification after surgery, but less data exist for patients treated with definitive radiation therapy (RT) or RT in oligo-/metastatic disease stages. To guide future perspectives of GCs for RT, we conducted (1) a systematic review on the evidence of GCs for patients treated with RT and (2) a survey of experts using the Delphi method, addressing the role of GCs in personalized treatments to identify relevant fields of future clinical and translational research. We performed a systematic review and screened ongoing clinical trials on ClinicalTrials.gov. Based on these results, a multidisciplinary international team of experts received an adapted Delphi method survey. Thirty-one and 30 experts answered round 1 and round 2, respectively. Questions with ?75% agreement were considered relevant and included in the qualitative synthesis. Evidence for GCs as predictive biomarkers is mainly available to the postoperative RT setting. Validation of GCs as prognostic markers in the definitive RT setting is emerging. Experts used GCs in patients with PCa with extensive metastases (30%), in postoperative settings (27%), and in newly diagnosed PCa (23%). Forty-seven percent of experts do not currently use GCs in clinical practice. Expert consensus demonstrates that GCs are promising tools to improve risk-stratification in primary and oligo-/metastatic patients in addition to existing classifications. Experts were convinced that GCs might guide treatment decisions in terms of RT-field definition and intensification/deintensification in various disease stages. This work confirms the value of GCs and the promising evidence of GC utility in the setting of RT. Additional studies of GCs as prognostic biomarkers are anticipated and form the basis for future studies addressing predictive capabilities of GCs to optimize RT and, European Union (EU); Horizon 2020; Research and Innovation Programme; German Federal Ministry of Education and Research (BMBF); ERA PER Joint Funding Call 2019; A.T. acknowledges support from Cancer Research UK (C33589/A28284 and C7224/A28724 CRUK RadNet). This project represents independent research supported by the National Institute for Health Research (NIHR) Biomedical Research Centre at the Royal Marsden NHS Foundation Trust and the Institute of Cancer Research, London. The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care. We thank Fotini Miltiadous for administrative support. ; Funding text 3: Disclosures: A.U.K. reports funding support from grant P50CA09213 from the Prostate Cancer National Institutes of Health Specialized Programs of Research Excellence and grant W81XWH-22-1-0044 from the Department of Defense, as well as grant RSD1836 from the Radiologic Society of North America, the STOP Cancer organization, the Jonsson Comprehensive Cancer Center, and the Prostate Cancer Foundation. C.Z. received funding from the Klaus Tschira foundation, Naslund Medical, and from the German Research Foundation. C.Z. received speaker fees from Johnson & Johnson and Novocure, all outside the submitted work. E.D. is an employee of Veracyte, manufacturer of Decipher. A.R. is a consultant and/or speaker for Astellas, Bayer, Pfizer, Blue Earth, Lantheus, Janssen, Tempus, and Veracyte. X.G. is on the consulting/advisory board for Bayer, Myovant, and Guardant Health.

Published
2023

47. Clinical Perspectives from Randomized Phase 3 Trials on Prostate Cancer: An Analysis of the ClinicalTrials.gov Database

Author

Tsikkinis, Alexandros, Cihoric, Nikola, Giannarini, Gianluca, Hinz, Stefan, Briganti, Alberto, Wust, Peter, Ost, Piet, Ploussard, Guillaume, Massard, Christophe, Surcel, Cristian I., Sooriakumaran, Prasanna, Isbarn, Hendrik, De Visschere, Peter J.L., Futterer, Jurgen J., van der Bergh, Roderick C.N., Dal Pra, Alan, Aebersold, Daniel M., Budach, Volker, and Ghadjar, Pirus

Published
2015
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