31 results on '"Ghazala, R."'
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2. Isotretinoin treatment upregulates the expression of p53 in the skin and sebaceous glands of patients with acne vulgaris
- Author
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Agamia, Naglaa F., primary, Mulla, K. F. El, additional, Elsayed, N., additional, Ghazala, R. A., additional, Maksoud, R. Abdel El, additional, Elmonem, E. Abdel, additional, Talat, E., additional, Zaki, I. I., additional, Sabah, R., additional, and Melnik, B. C., additional
- Published
- 2022
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3. Evaluation of appendicitis risk prediction models in adults with suspected appendicitis
- Author
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Nepogodiev, D., Matthews, J. H., Morley, G. L., Naumann, D. N., Ball, A., Chauhan, P., Bhanderi, S., Mohamed, I., Glasbey, J. C., Wilkin, R. J. W., Drake, T. M., Clements, J., Blencowe, N. S., Herrod, P. J. J., Pata, F., Frasson, M., Blanco-Colino, R., Soares, A. S., Nepogodiev D, Bhangu A., Matthews, Jh, Morley, Gl, Naumann, Dn, Ball, A, Chauhan, P, Bhanderi, S, Mohamed, I, Glasbey, Jc, Wilkin, R, Drake, Tm, Clements, J, Blencowe, Ns, Herrod, P, Pata, F, Frasson, M, Blanco-Colino, R, Soares, As, Bhangu, A, Nepogodiev, D, Jain, S, Amuthalingam, T, Tyler, R, Griffiths, Ea, Pinkney, Td, Gee, O, Morton, Dg, Beggs, A, Beral, D, Bowley, D, Cruickshank, N, Daniels, I, Griffiths, E, Hornby, St, Lund, Jn, Marriott, P, Singh, P, Smart, Nj, Speake, D, Thompson, C, Torkington, J, Torrance, A, Vohra, R, Warren, O, Winter, Dc, Pellino, G, Sgrò, A, Simioni, A, Farina, V, Podda, M, Di Saverio, S, Birindelli, A, Pasquali, S, Itsurg, Surg, Pt, Bolton, W, Bradshaw, Cj, Chean, Cs, Harris, G, Haddow, Jb, Jamieson, Nb, Mccain, S, Mason, J, Milgrom, D, Nana, Gr, Mohamed, Mn, Brien, Jo, Pearce, J, Rabie, M, Sahnan, K, Sarmah, P, Skerritt, C, Ghazanfar, Ma, Sreedharan, L, Kabwama, S, Gray, Rt, Kamande, Iw, Nazarian, S, Dar, Fa, Misky, At, Arunachalam, S, Twum-Barima, Cs, Mohamed, Im, Connor, Kl, Coe, Po, Kosti, A, Elshaer, M, Colvin, Da, Charalambous, Mp, Yeung, K, Merker, L, Morrison, T, Thaventhiran, Aj, Gilbert, Tm, Clements, Jm, Hicks, G, Afshar, S, Mckinley, Nc, Assaf, N, Hanna, T, Macinnes, E, Thavanesan, N, Dubois, As, Palani-Velu, Lk, Tezas, S, Yow, L, Radwan, Rw, Abdelrahman, M, Lee, Ka, Zarka, Za, Mcdowall, Na, Tan, Cy, Venn, Ml, Ashmore, Dl, Whitehorn, Se, Golder, Am, Reddy, A, Delimpalta, C, Kay, Oh, Shah, Sm, Eiben, I, Doyle, C, Tudyka, V, Issa, E, West, H, Brewer, Hk, Farrow, Ez, Taylor, Ns, Smart, Cj, Griffiths, Np, Halkias, C, Vitish-Sharma, P, Knight, Sr, Mowbray, Ng, Olivier, Jb, Lee, Kj, Clement, Kd, Chrastek, D, Panda, N, Connor, Mj, Fahmy, Se, Bryan, Es, Ngu, Ws, Adegbola, So, Vaughan, Em, Stupalkowska, W, Simmonds, L, Malik, A, Hussein, A, Karim, Mj, Singhal, T, Ormiston, R, Kung, V, Rabie, Ma, Park, Jh, Lal, N, Worku, D, D'Auria, M, Ang, A, Orizu, M, Gammeri, E, Clough, E, Choy, Ch, Lawday, S, Hann, Aj, Robinson, D, Wardle, Bg, Mcdonnell, D, Rutherford, Dg, Hickey, Lm, Garg, Ag, Rezvani, S, Bell, Cr, Mahmood, F, Rehman, S, Donaldson, G, Peleki, A, Pearce, L, Sharp, Ol, Singh, S, Thompson, Db, El-Tayar, O, Hollyman, M, Rupasinghe, Sn, Toomey, Db, Murray, Mp, Amtul, N, Mersh, Rj, Newton, Rc, Al-Khyatt, W, Stephens, Gf, Abbas, Sh, Iqbal, Mr, Brown, Ce, Renshaw, S, Hureibi, Ka, Pullabatla-Venkata, Up, Donohoe, No, Myatt, A, Egan, Rj, Rangarajan, K, Trail, M, Mckay, Sc, Engall, N, Jerome, E, Townsend, Dc, Patel, By, Pronin, S, Chandratreya, N, Choong, Jh, Mohamed, Tm, Hudson-Peacock, Nj, Manson, R, Hebbar, K, Mothe, Bs, Weegenaar, Cr, Saad, M, Bowman, Cr, Serventi, F, Fleres, F, Foppa, C, Pata, G, Baronio, G, Pertile, D, Lucchi, A, Sagnotta, A, Maretto, I, Campagnaro, T, Gatti, M, Gjoni, E, Roscio, F, Inama, M, Coccolini, F, Colombo, F, Avanzolini, A, Aresu, S, De-Manzoni-Garberini, A, Merlini, Da, Chessa, A, Tamini, N, Mulas, S, Cillara, N, Coletta, D, Atzeni, J, Erdas, E, Gallo, G, Francone, E, Di Gioia, P, Bianchi, Cl, Ferrara, F, Biancafarina, A, Scabini, S, Marano, L, Miegge, A, Sasia, D, Savino, G, Scatizzi, M, D'Amico, Fe, Arcuri, Ga, Gavagna, L, Salamone, G, Tatulli, F, Goldin, E, Matos, Ml, Caldeira, Ab, Romano, J, Pereira, J, Azevedo, J, Azevedo, Jm, Simoes, J, Silva, A, O'Leary, Dp, Kennedy, Nd, Quinn, Em, Zhang, Ay, Neary, Pm, De-Marchi, Ja, O'Connor, Br, Wijesundera, K, Foley, Nm, Wong, J, Tiedt, La, Bolger, Jc, Connelly, Tm, Ahmed, Os, Vigorita, V, García, V, Arredondo, J, Redondo, E, Sainz, B, Aldrey, I, Landaluce-Olavarria, A, Gómez, Aa, Cordoba, E, Sánchez-Fuentes, Mn, Cerdán-Santacruz, C, Beltran-De-Heredia, J, García, M, Veres, T, García-Novoa, A, Abellán, Am, García-Catalá, L, Ruiz-Marín, M, Menendez, P, Roldán-Ortiz, S, Navas-Cuéllar, Ja, Sabia, D, Gomez-Rosado, Jc, Navidad, Ms, Caula, C, Sanchez, Er, Espin-Basany, E, Fernández-Martínez, D, Bravo-Gutiérrez, Af, Payá-Llorente, C, Dujovne, P, Lima, F, Soria-Aledo, V, Gomez, Cj, Pascual-Miguelañez, I, Muinelo, M, Alvarez, Cm, Vargas-Pierola, Hj, Vallve-Bernal, M, Hidalgo-Rosas, Jm, Arenal-Vera, Jj, Sena-Ruiz, F, Sanchez-Guillen, L, Villarejo-Campos, P, Tallon-Aguilar, L, Garcea, A, Bennett, Jm, Whittaker, L, Gidwani, Al, Byrnes, Ck, Saunders, S, Shiwani, Mh, Ashraf, N, Venkatasubramaniam, Ak, Bevan, Ke, Mcarthur, D, Mustafa, Ak, Griffith, Jp, Blazeby, Jm, Charalabopoulos, A, Campbell, W, Reese, G, Warren, Oj, Peacock, M, Menzies, D, Jenner, D, Eardley, Nj, Yoong, S, Abulafi, M, Avalapati, H, Thompson, R, Nastro, P, Kochupapy, R, Stubbs, Bm, Mcintyre, R, Crozier, J, Patel, Pk, Pento, V, Beasley, Wd, Roxburgh, C, Youssef, H, Alexander, R, Denley, S, Di Franco, F, Quddus, A, Saha, A, Hunter, I, Hannay, J, Velchuru, Vr, Bond-Smith, G, Salama, Y, Bhargava, A, Panagiotopoulos, Sp, Watson, N, Garcea, G, Boddy, Ap, Dunning, Pg, Lloyd, G, Gurjar, Sv, Hill, J, Andrews, B, Singh, A, Ruzvidzo, F, Shingler, G, Mahon, D, Elgaddal, S, Payne, Cj, Shaikh, Ia, Dalmia, S, Nair, Ms, Finch, Jg, Chapple, Ks, Bawa, S, Watfah, J, Carden, Ca, Makhija, R, Rao, M, Sarveswaran, J, Vijay, V, Rekhraj, S, Knight, B, Siddiqui, Mn, Sebastian, Jf, Glen, P, Vakis, S, Ebied, H, Rajaram, R, Gray, J, Mcgrath, D, Faulkner, G, Gopalswamy, S, Varcada, M, Woodward, A, Williams, Gl, Szentpali, K, Ravindran, R, Bronder, C, Thaha, Ma, Rate, A, Shetty, Vd, Rao, V, Sajid, Ms, Clements, B, Patel, Rt, Mason, C, Branagan, G, Maude, K, Kaur, G, Lyons, A, Ainsworth, P, Hagger, R, Zadi, Az, Maslekar, Su, Kinross, J, Irukulla, S, Hawkins, W, Wheatstone, S, Magro, T, Bailey, S, Marshall, G, Mccullough, J, Marangoni, G, Leung, El, Borg, Cm, Gopinath, S, Kirkby-Bott, J, Yalamarthi, S, Mirza, S, Brett, M, Ramcharan, S, Pandey, V, Thava, B, Andreani, Sm, Sahay, Sj, Aravind, B, Downey, M, Nicol, D, Whitehouse, P, Sharma, A, Francis, N, Chitsabesan, P, Stewart, Dj, Norcia, Gg, Cucinotta, E, Cianchi, F, Romario, Uf, Taglietti, L, Capelli, P, Garulli, G, Parisi, A, Nitti, D, Guglielmi, A, Alonzo, A, Scandroglio, Is, Moretto, G, Ansaloni, L, Pietrabissa, A, Foschi, D, Vettoretto, N, Ercolani, G, Coppola, M, Colangelo, E, Morandi, E, Niolu, P, Pala, M, Coletti, M, Pisanu, A, Nicolosi, A, Sammarco, G, Berti, S, Soliani, P, Tonini, V, Stella, M, Ceccarelli, G, De Nisco, C, Castagnoli, G, De Nardi, P, Borghi, F, Agresta, F, Benevento, A, Cantafio, S, Cesari, Mc, Rubbini, M, Chetta, G, De Marchi, F, Nora, Mf, Sousa, Hs, Nascimento, Ca, Casimiro, C, Costa, Sd, Rosa, Mj, Carvalho, N, Correia, J, Gomes, Ap, Hill, Ad, Walsh, Tn, Aremu, Ma, Mulsow, J, El-Masry, S, Gillick, J, Garvin, J, Caldwell, M, Mehigan, B, Peirce, Cb, Cooke, F, Mealy, K, Ruano, A, Ais, G, Fueyo, J, Parajó, Ae, Bernal-Sprekelsen, Jc, Monzón-Abad, Ja, Blanco, F, Arroyo, A, Bazán-Hinojo, Mc, Ramos-Bernado, Mi, Lopez-Ruiz, Ja, Golda, T, Julià, D, Cuadrado, Mm, Gómez-Abril, Sa, Martinez, J, Aguayo, Jl, Millan, M, Alvarez-Gallego, M, Muinelo-Lorenzo, M, Parra, Jm, Muñoz-Muñoz, E, De Chaves-Rodríguez PG, Cánovas-Moreno, G, Rodriguez-Lopez, M, Segura-Sampedro, Jj, García-Granero, A, Redondo-Calvo, Fj, Dyson, S, Thakur, D, Swords, C, Siaw, O, Zelazek, M, Woo, R, Badran, A, Aruparayil, N, Christopoulos, P, Chambers, B, O'Neill, N, Long, Rh, Mccaughey, P, Wong, Ml, Mccain, Rs, Lennox-Warburton, Hc, Moore, C, Manektella, Km, Mcilwaine, S, Rupani, S, Simpson, Dj, Wauchope, J, Ng, M, Christian, L, Crone, A, Sacks, R, Symons, N, Lazzaro, A, Patil, Sd, Roomi, S, Silva, I, Hodgson, Jm, Ly, C, Froud, H, Patel, H, Cay, P, Karwal, Rs, Danquah-Boateng, D, Berry, B, Esmail, Hd, Maripi, H, Bilku, D, Mckelvie, Ma, Miller, K, Maina, A, Velho, R, Hasan, R, Clingan, R, Jah, S, Waite, K, Jones, A, Buckley-Jones, S, Lecky-Thompson, L, Saghir, N, Mansoor, S, Mistry, D, Brown, R, Wong, A, Gurung, S, Wensley, F, Fleming, Ta, Griggs, R, Haines, S, Bedoya, S, Beverstock, A, Johnson, J, Govind, G, Niaz, O, Dyal, A, Tokidis, E, Punj, S, Leusink, A, Rudland, I, Kelly, M, Morgan, R, Al-Musawi, S, Lek, C, Gilbert, A, Gosal, A, Mahoney, R, Parwaiz, I, Mitchard, Mj, Ribeiro, B, Merai, H, Dean, Ea, Khan, S, Baginski, A, Mann, C, Foers, W, Jones, L, Woodward, B, Mcwhirter, Dm, Thomas, At, Gilbert, Tg, Weatherburn, Lw, Pilkington, Jp, Cameron, Fc, Clements, Jd, Mccann, C, Davidson, S, Hackney, L, Clements, Js, Martin, A, Du, Dt, Shakoor, Z, Yen, Sk, Adnan, M, Ranathunga, S, Sana, S, Tay, Yh, Chin, My, Gillespie, M, Brown, Ag, Campbell, U, Chatzikonstantinou, M, Mahendran, B, Flack, T, Chowdhary, M, Lim, Jm, Whiteman, E, Shepherd, Ja, Pedder, A, Siggens, Kl, Lai, Cw, Morrison-Jones, V, Hayat, Z, Nehikhare, I, Macleod, C, Quinn, Hc, Brown, A, Neagle, G, Chok, Sm, Carrano, Fm, Abbassi, Oa, Divekar, Ga, Halmer, S, Adams, Re, Davies, Pl, Wong, Sy, Amarasinghe, R, Tague, Le, Jones, E, Singh, J, Boza, K, Kelly, Sd, Morrison, F, Chan, Wh, Wilson, Ej, Awokoya, Oo, Griffiths, Sn, Kirkham, En, Cotton, Ae, Adimonye, A, Leighton, Pa, Abdelrahman, A, Cartwright, H, Gates, Z, Miguras, M, Khan, K, Louw, C, Grove, T, Badenoch, T, Mckeon, J, Wood, Cs, Leitch, Rp, Sgardelis, P, Perera, Mi, Nagarajan, D, Malam, Y, Theodoropoulou, K, Rajagopal, S, Kaptanis, S, Popova, D, Olagbaiye, O, Tayeh, S, Rigby, S, Harris, Mp, Ren, Kz, Liaw, G, Zhou, S, White, F, Marshall, Cm, Mitchell, Jh, Anderson, Dj, Kanakala, V, Hollingsworth, A, Paramasevon, Kr, Milward, J, Ahmed, S, Fanibi, Bf, Ferguson, N, Dickson, Ea, Shaw, Av, Dixon, F, Morrish, S, Dandy, R, Fooks, P, Sharma, P, Islam, N, Tabain, V, Keegan, R, Ahel, J, Alhammali, T, Graveston, J, Balai, Ej, Rothnie, K, Pankin, Gp, Eiben, Ie, Jackson, Nj, Dhar, M, Nash, D, Dharamavaram, S, Seth, M, Chowdhury, F, Rezacova, M, Seneviratne, N, Turner, Ej, Currow, C, Isherwood, Jd, Hobson, Bm, Lui, Dh, Rodger, V, Ting, N, Photiou, D, Taze, D, Lodhia, S, Earnshaw, L, Kumar, K, Neale, A, Bastianpillai, J, Cipparrone, M, Barrie, A, Nash, Z, Anandan, L, Tailor, K, Vinnicombe, Z, Krivan, S, Kuo, R, Giorga, A, Habib, H, Malik, K, Bogdan, M, Mahon-Daly, Fp, Athersmith, Mj, Strange, Ja, Wheeler, C, Summerfield, L, Khaw, Ra, Ashour, O, Iosif, E, Fadel, M, Gopalakrishnan, K, Orme, N, Williams, S, Rashid, M, Sultana, A, Patel, N, Pearson, R, Yasin, T, Bevan, V, Al-Sarireh, B, Brown, M, Mohd, N, Howie, Ee, Poudevigne, M, Paget, C, Rallage, H, Chui, K, Fawzi, F, Layman, S, Okorocha, E, Jama, Gm, Orawiec, P, Kouli, O, Hassane, A, Kilkenny, J, Devine, Aa, Laurenson, M, Slezak, I, Barker, T, Lau, E, Limbada, M, O'Brien, J, Weaver, J, Hajibandeh, S, Shah, J, Mansour, Mm, Malik, Sn, Davis, S, Trew, F, Bandyopadhyay, Sk, Dart, K, Guru-Naidu, S, Callan, R, Nair, Mk, Alani, M, Sezen, E, Salim, S, Shurlock, J, Siddique, K, Forouzanfar, A, Brews, R, Acharya, A, Jain, A, Tozer, Pj, Warusavitarne, J, Emslie, Km, Collier-Wakefield, O, Sivaloganathan, P, Dobson, C, Elseedawy, M, Mcnally, L, Williams, M, Motiwala, Fh, Choi, S, Asmadi, Aa, Burnside, D, Everden, A, Suriyakumar, S, Sandu, L, Kent, Da, Bowen, J, Long, P, Khair, A, Shah, K, Phelan, L, Pierre, R, Dhari, Aa, Hoff, M, Nickson, S, Setshwaelo, T, Chalk, A, Parkola, Mj, Harlinska, A, Chan, T, Dudek, Jg, Rolph, R, Allen, M, Pollard, H, Gormely, R, Finlayson, H, Ljungqvist, G, Peponis, C, Rahman, M, Dhesi, S, Arshad, F, Faris, Ar, Sooriyamoorthy, T, Springate, El, Barnieh, W, Patel, As, Siddiqui, Za, Chishti, Ia, Ayube-Brown, J, Rabie, Mr, Blake, L, Yardimci, E, Nagendram, S, Neophytou, Gi, Henderson, L, Farhan-Alanie, M, Kong, Cy, Ghazala, R, Evans, J, Hussain, N, Kabir, M, Hraishawi, I, Cox, M, Bailey, Ja, Muhibullah, N, Yanni, F, Stevenson, R, Nair, A, Murphy, C, Mcgucken, O, Pandya, R, Bowerman, H, Lafaurie, G, Van Boxel GI, Shanmugarajah, K, Maragouthakis, D, Hanif, Z, Evans, Jd, Yoganathan, S, Richardson, Td, Cook, V, Clark, Gl, Rigney, B, O'Neill, E, Guliani, J, Chan, D, Harper, F, Sian, T, Boereboom, C, Blackwell, J, Hardy, E, Boyd-Carson, H, Couch, Dg, Barter, Ca, Thoukididou, Sn, Hatt, Jr, Jones, Cs, Dean, S, Rajaretnam, N, Masood, M, Thakral, N, Griffith, D, Doherty, C, Longshaw, A, Peprah, D, Mathew, G, Hook, A, Vance-Daniel, J, Ibrahim, Y, Walters, Kj, Whewell, He, Sherif, Ma, Mckenna, M, O'Sullivan, D, Woodrow, C, Gill, S, Johnstone, A, Gentry, R, Irwin, R, Forgie, A, Welsh, S, Ivey, P, Bullivant, Jk, English, Wj, Osterberg, A, Morowala, A, Al-Faham, Z, Islam, S, Tan, E, Sadek, S, Sihra, N, Shrestha, D, Chong, B, Nadeem, A, Fasuyi, Ja, Patel, Mm, Daureeawoo, R, Okekunle, B, Cheruvu, M, Mazumdar, E, Hussain, A, Patel, C, Mcquaid, M, Banks, A, Robinson, A, Khan, Ms, Riaz, W, Verroiotou, M, Cohen, Ja, Kouroumpas, E, Ghaffari, I, Moradzadeh, J, Kamal, M, Gulamhussein, M, Gaines, E, Ghatorae, S, Clark, S, Savill, A, Hutchinson, B, Chapman, J, Wu, F, Creasy, W, Raymond, M, Grosvenor, S, Odeh, A, Malik, Y, Bansal, H, Grant, C, Raofi, A, Ahmed, B, Mai, D, Souter, J, Hamelmann, Rn, Ikram, S, Durbacz, M, Gilliland, N, Salem, A, Chudek, D, Ladwa, N, Storey, R, Fontaine, C, Toomey, D, Miller, B, Oakey, M, Smoker, H, Chapman, Sj, O'Hagan, Sc, Tahir, W, Wilcox, G, Ahmad, A, Akram, F, Baddams, Ts, Boshier, Pr, Fehervari, M, Easdon, S, Ilozue, T, Adam, Me, Jokhan, S, Foster, A, Nambiar, K, Bohra, P, Janardanan, S, Shanmuganathan, V, Maqboul, F, Ettles, C, Wardle, Sd, Martinou, E, Khasria, A, Bagga, R, Motter, D, Mundkur, N, Pan, Y, Akbari, K, Farrell, Sm, Rahim, A, Gummaraju, A, Mahmoud, A, Akinsola, O, Smallcombe, N, Tarazi, M, Hanley, C, Campbell, Um, Franklin, D, Davidson, Jr, Raza, Ss, Krishnamoorthy, A, Rajjoub, Y, Ali, M, Seddon, Tc, Payne, Re, Das, A, Martin, Lm, Naismith, Kn, Venkata, Up, Manda, Vm, Burns, Km, Huang, J, Samuel, M, Docherty, Ja, Cheah, Wl, Ooi, R, Nyeko-Lacek, M, Marsh, L, Prideaux, A, Li, Ch, Poacher, A, Lee, M, Muzaffar, M, Kara, A, Walsh, E, Sunter, H, Roth, N, Roy, C, Mcmorran, D, Turnbull, A, Layton, Gr, Archer, Je, Yang, P, Douka, E, Amin, V, Borghol, K, Blackford, Od, Bond, S, Baker, B, Mohamed, Wo, Williams, R, Garnham, J, Robb, Hd, Allington, J, Cloney, L, Tamborska, A, Kalia, K, Fung, E, Johnston, Z, Lynch, L, Christides, A, Tan, Hl, Cynthia, G, Tsang, B, Rossi, C, Kaubrys, M, Al-Khafaji, N, Jenkins, M, Peiris, Gb, Gunning, S, Nimako, E, Pandya, D, Hever, P, Amayo, A, Bull, C, Clements, C, Al-Sheikh, M, Savioli, F, Long, M, Horsfield, E, Robertson, C, Ogboru, S, Mcilwrath, Ac, Bell, J, Limb, C, Obeid, N, Rich, Je, Balasubramaniam, A, Mashar, R, Taylor, M, Bruce, Js, Dennison, G, Curtis, Nj, Ezerska, E, Ellis, B, Wiggill, S, Tee, A, Ng, S, Carder, C, Abdelwahed, A, Chandler, Sb, Tinsley, Bj, Finotti, E, Occhioni, G, Cossu, F, Vulcano, I, Viscosi, F, Michelini, M, Compagnoni, B, Sepe, C, Isolani, Sm, Regina, G, Alagna, V, Martorelli, G, Gabbianelli, C, Moroni, P, Zuin, M, Conci, S, Lazzari, G, Costamagna, D, Zurleni, Tz, Altomare, Ma, Desiderio, J, Di Cintio, A, Gemini, A, Trastulli, S, Viviani, E, Tomasoni, M, Montori, G, Harder, G, Argenti, F, Malabarba, S, Checcacci, P, Montanelli, P, Guerra, F, Skalamera, I, Staderini, F, Grandi, S, Nelli, T, Coratti, F, Sorrentino, L, Maffioli, A, Cavallo, D, Bondurri, A, Groppo, G, Curti, R, Solaini, L, Xidas, A, Manias, T, Delogu, D, Vacca, A, Solinas, L, Corbellini, C, Fiore, L, Nigro, A, Santurro, L, Angrisani, M, Sparta, C, Lorettu, A, Mura, Fa, Ruggiu, Gv, Pirari, Pf, Pau, R, Melis, M, Piu, F, Patti, S, Deserra, A, Angelieri, D, Del Basso, C, Rossi, D, Iannone, I, De Padua, C, Giubilo, C, Falaschi, F, Cirillo, B, Gordini, L, Podda, F, Sanna, S, Saba, A, Poillucci, G, Pinna, E, Messina, A, Sena, G, Cardona, R, De Luca, E, Sacco, R, Vescio, G, Ammendola, M, Romano, R, Bianco, A, Bonfante, P, D'Ambra, L, Feleppa, C, Gennai, A, Lizzi, V, Moggia, E, Imperatore, M, Bolzon, S, Belvedere, A, Amaducci, E, Ripoli, Mc, Segalini, E, Cervellera, M, Vaccari, S, Eretta, Co, O'Neill, R, Llewelyn, O, Jones, N, Clerici, F, Ballabio, M, Andolfi, E, Angelini, M, Fontani, A, Miranda, E, Scricciolo, M, Provenza, G, Pellicanò, Ga, Pulighe, F, Argenio, G, Melis, A, Balestra, F, Anania, M, Cruccu, A, Massaiu, C, Murru, Ml, Martino, A, Luzzi, Ap, La Valle, G, Chillitupa, Cz, Bartoli, A, Conti, D, Spaziani, A, Bellochi, R, Listorti, C, 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E., Espinosa J., Carral-Freire M., Martinez-Almeida R., Santarrufina-Martinez S., Sebastian-Tomas J.C., Gonzalvez-Guardiola P., Fernandez E.C., Mozo A.S., Stoyanov T.I., Santamaria P.C., Grimaldo E.G., Fernandez-Candela A., Curtis-Martinez C., Del-Valle-Ruiz S.R., Sanchez-Cifuentes A., Ramirez-Faraco M., Lopez A.F., Leon C., Kumar S., Fornell-Ariza M., Ayllon-Gamez S., Pena-Barturen C., Ojea-Ruiz-Yherla L., Saavedra-Chacon M., Perez-Calvo J., Gomez-Facundo H., Riba-Combatti L., Manas O.C., De-Soto-Cardenal B., De-La-Herranz-Guerrero P., Dominguez-Sanchez C., Gamero-Huaman J.C., Suarez-Cabrera A., Ramirez-Redondo A.A., Lara-Fernandez Y., Bascuas-Rodrigo B., Lopez-Duran B.L., Pigem A., Gil J., Salvador H., Planellas P., Farres R., Caballero A., Arnau M., Tapiolas I., Ridaura N., Roncero L.S., Collado-Roura F., Fijo L.M., Cormenzana O.B., Vinas N.L., Grifell M.S., Prats M.A., Torrado A.A., Sanz-Navarro S., Contreras-Saiz E., Solar-Garcia L., Moreno-Gijon M., Suarez-Sanchez A., Diaz-Vico T., Rodicio-Miravalles J.L., Garcia-Gutierrez C., Pila U., Melone S., Martin-Prieto L., Rojo J.A., Gonzalez M., Zorrilla L., Garcia-Marin J.A., Baeza-Murcia M., Pellicer-Franco E., Jimenez-Ballester M.A., Asensio-Gomez L., Gortazar-De-Las-Casas S., Guevara-Martinez J., Ramirez L., Verea S., Anguita F., Navarro G., Criado ADC., Lara M.C., Martinez E.T., Sanchez-Martinez A., Hernandez-Gimenez L., Galofre-Recasens M., Ferrer-Vilela I., Perez-Sanchez L.E., Esteves M.B., Menendez-Moreno A., Baz-Figueroa C., Rosat A., Hontoria M.S., Garcia N.A., Gracia-Roman R., Pascua-Sole M., Pino-Perez O., Garcia-Perez J.M., Pineno-Flores C., Ambrona-Zafra D., Sancho-Muriel J., Alvarez E., Jimenez-Rosellon R., Daga O., Alberca-Paramo A., Sanchez-Garcia S., Garcia-Santos E., Pareja-Ciuro F., Olivares-Oliver C., Navarro-Morales L., Tamayo-Lopez M.J., Tinoco-Gonzalez J., Garcia-Rivera C.O., Agua I.A., Moreno-Suero F., Pereira-Mosquera E., Zerpa C., Llacer E., Diaz A., Caro A., Feliu F., Franco M., Escuder J., Abellan M., Padilla E., Mambrilla-Herrero S., Plua-Muniz K.T., Bailon-Cuadrado M., Tejero-Pintor F.J., Choolani-Bhojwani E., Vila-Zarate C., Delgado-Plasencia L.J., Ponchietti L., Cousins L., Busuttil A., Baird C., Drye N., Brown O.D., Mansour S., Anderson O., Mahapatra R., Clements J.A., D'Souza N., Littlehales D.J., Tang A.M., Byrne B.E., Cunha P., Ogbuokiri C., Eiben P., Gravante G., Kho H., Dobbs S., Doulias T., Ng J., Wilson M., Venugopal R., Wolff J., Akhtar K., Walji H.D., Tognarelli J.M., Knight K.A., Ansari A., Hussaini S.A., Wright E., Brewer H., Rinkoff S., Harries R.L., Fairfield C.J., Abbott T., Jackson A., Wright H.L., Walters U., Carney K., Logan P.C., Mughal Z., Strachan E., Chasty B., Ma J., Mazzeo C., Badii B., Armellini A., Grassia M., Perin A., Ruzzenente A., Magnoli M., Depalma N., Longheu A., Papandrea M., Dova L., De Prizio M., Gusai G.P., Di Zitti L., Geretto P., Azabdaftari A., Chianese G., Elbetti C., Ruffolo C., Giaccari S., Devezas V., Ferreira J.S., Peixoto R., Alshafei A., Simo V., Jose H.S., Ugarte-Sierra B., Salva A.B., Gomez N., Marinello F., Medina-Arana V., Vega L., Ballester M.M., Espina B., Prieto-Nieto M.I., Rodriguez E.C., Padilla-Valverde D., and Duran-Munoz-Cruzado V.M.
- Subjects
Adult ,humanos ,Decision Making ,Risk Assessment ,NO ,apendicectomía ,apendicitis ,evaluación de riesgos ,Appendectomy ,Humans ,hospital ,General ,collaborative ,LS7_4 ,right iliac fossa ,appendicitis ,emergency service ,Original Articles ,adulto ,Appendicitis ,adult ,appendectomy ,humans ,risk assessment ,decision making ,Lower GI ,Original Article ,appendicitis, prediction models, right iliac fossa pain ,Emergency Service, Hospital ,toma de decisión - Abstract
Background Appendicitis is the most common general surgical emergency worldwide, but its diagnosis remains challenging. The aim of this study was to determine whether existing risk prediction models can reliably identify patients presenting to hospital in the UK with acute right iliac fossa (RIF) pain who are at low risk of appendicitis. Methods A systematic search was completed to identify all existing appendicitis risk prediction models. Models were validated using UK data from an international prospective cohort study that captured consecutive patients aged 16–45 years presenting to hospital with acute RIF in March to June 2017. The main outcome was best achievable model specificity (proportion of patients who did not have appendicitis correctly classified as low risk) whilst maintaining a failure rate below 5 per cent (proportion of patients identified as low risk who actually had appendicitis). Results Some 5345 patients across 154 UK hospitals were identified, of which two‐thirds (3613 of 5345, 67·6 per cent) were women. Women were more than twice as likely to undergo surgery with removal of a histologically normal appendix (272 of 964, 28·2 per cent) than men (120 of 993, 12·1 per cent) (relative risk 2·33, 95 per cent c.i. 1·92 to 2·84; P, Women in the UK had a disproportionate risk of admission without surgical intervention and had high rates of normal appendicectomy. Risk prediction models to support shared decision‐making were identified by identifying UK adults at low risk of appendicitis. An online calculator is available (http://appy-risk.org). WCC, white cell count; CRP, C‐reactive protein; AIRS, Appendicitis Inflammatory Response Score; AAS, Adult Appendicitis Score. Important differences between men and women
- Published
- 2019
4. SAT0034 CLINICAL SIGNIFICANCE OF ANTI-CARBAMYLATED PROTEIN ANTIBODIES IN PREMENOPAUSAL RHEUMATOID ARTHRITIS WOMEN: RELATION TO DISEASE ACTIVITY AND BONE LOSS
- Author
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Elnemr, R., primary, Bastawy, R., additional, Ghazala, R., additional, Abdelrazek, M., additional, and Elsawy, N., additional
- Published
- 2020
- Full Text
- View/download PDF
5. Drug utilization evaluation of Piperacillin/Tazobactam: A prospective and cross sectional investigation in tertiary care setup
- Author
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Ubaidullah, Korai, Ghazala R, Naqvi, Farya, Zafar, Huma, Ali, Sadaf, Naeem, Nausheen, Alam, Rehana, Saeed, Sadaf, Farooqi, and Tazeen, Hussain
- Subjects
Adult ,Aged, 80 and over ,Male ,Tertiary Healthcare ,Middle Aged ,Drug Utilization ,Anti-Bacterial Agents ,Young Adult ,Cross-Sectional Studies ,Drug Utilization Review ,Piperacillin, Tazobactam Drug Combination ,Humans ,Drug Therapy, Combination ,Female ,Prospective Studies ,Aged - Abstract
Drug utilization evaluation (DUE) is an arrangement of continuous, orderly, criteria-based assessment of medication utilizes to guarantee that medicines are utilized suitably. In the event that treatment is regarded to be improper, provider and patient intervention may be important to optimize therapeutic efficacy. In the present study drug utilization evaluation of Piperacillin/Tazobactam was carried out in prospective manner. A well structured data collection form was constructed to collect the related information regarding demographic, clinical use, indication, culture sensitivity criteria, outcomes of therapy, renal impairment cases of dose adjustments and appropriate use. Results of chi square indicated insignificant relationship between gender and as p value was found to be p=0.446 and 0.111 for use of drug alone and in combination. Similarly insignificant relationship between gender and use of drug in combination with other antibiotics as p value was found to be p=0.111. It was found that from 61-70 years (Therapeutic Effectiveness; n=12, 9.37%), (Therapeutic Failure; n=10, 45.45%) and mortality (n=1, 50%) were quite higher. The prescription pattern was in accordance with standard guidelines. Study indicated need to elevate prescribers to pursue generic prescribing and rationally utilize antibiotics to avert advancement of resistance at the level of hospital and community. These sorts of studies are valuable for acquiring data about medication utilize designs and for recognizing inconceivable expense of medicines.
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- 2019
6. Drug utilization and prescribing pattern of antibiotics in a tertiary care setups; trends and practices
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Huma, Ali, Farya, Zafar, Shazia, Alam, Anwar Ejaz, Beg, Rabia, Bushra, Ammara, Manzoor, Ghazala R, Naqvi, Riffat, Yasmeen, Yousra, Shafiq, Anum, Tariq, Saba, Zubair, and Saima, Saleem
- Subjects
Adult ,Male ,Adolescent ,Tertiary Healthcare ,Middle Aged ,Drug Utilization ,Anti-Bacterial Agents ,Young Adult ,Cross-Sectional Studies ,Drug Utilization Review ,Humans ,Female ,Pakistan ,Guideline Adherence ,Practice Patterns, Physicians' ,Retrospective Studies - Abstract
Irrational, over and misuse of antibiotics arise as global concern in both hospital and community settings and lead to adverse events including antimicrobial resistance, associated health problems, amplified hospitalization stay and cost. Hence, Drug Utilization Evaluation (DUE) studies are designed to evaluate and improve the prescribing, administration and the rational use of medications. The present study was designed to assess the pattern of antimicrobial drug utilization in in-patients cohort of tertiary care setup in Karachi, Pakistan. This cross sectional observational study was conducted in retrospective manner. World health organization (WHO) guidelines and criteria are considered to evaluate the appropriateness of drug use in various disease conditions. ATC/DDD system was applied to determine the study outcome. High frequency of antibiotics utilization found in respiratory tract infections of both lower (LRTI) 16.8% (n=42) and upper (UTI) 13.2% (n=33). The estimated total number of drug units administered per month was greater with cefixime (46) and ciprofloxacin (45) both. DDD/100 bed days drug utilization of antibiotics was higher with ciprofloxacin, cefexime and meropenem (47, 46 and 29.25) correspondingly. In conclusion, the current investigation signifies extensive scope for progress in prescribing trend. Drug adherence to customary guidelines of disease management and constraint policies to endorse judicious drug use may be considered vital in healthcare setup.
- Published
- 2018
7. Incidence of drug interactions in intensive care units in tertiary care settings: Classification, facts and measures
- Author
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Hina, Hasnain, Huma, Ali, Farya, Zafar, Ali Akbar, Sial, Shazia, Alam, Anwar Ejaz, Beg, Rabia, Bushra, Mehwish, Rizvi, Maqsood Ahmed, Khan, Huma, Shareef, Ghazala R, Naqvi, and Anum, Tariq
- Subjects
Male ,Intensive Care Units ,Time Factors ,Tertiary Healthcare ,Incidence ,Polypharmacy ,Humans ,Drug Interactions ,Female ,Pakistan ,Middle Aged ,Classification - Abstract
Drug-drug interactions (DDIs) are extremely significant concern, particularly in sensitive population including pediatric and geriatric. Propensity for the development of DDIs is high in patients admitted at intensive care units (ICU). This study was conducted to evaluate the DDIs incidence, facts and measures in ICU. From a total of 150 cases studied for ICU patients, with the mean age of 56.37±12.45 years, 55.33% were male and the rest were female 44.66%. The demographic information like age, gender and main diagnosis details of study participants that were extracted from the patients' clinical record. A statistically significant association between the drug interaction and the number of drugs prescribed per prescription was observed (p0.0001). Concerning the onset of outcome, 52% of DDIs distinguished as delayed onset of effect (past 24 hours) and 35% were categorized as rapid onset (within 24 hours). Despite the facts regarding patient safety and minimizing DIs error, polypharmacy is still frequent in critically ill patients admitted in ICU attributed high risk of adverse reactions due to use of multiple interventions to treat severity of disease condition. Such studies may be used to develop an effective tool for the diagnosis and management of DDIs.
- Published
- 2018
8. Assesment of predictor variables and clinical consequences associated with surgical site infection in tertiary care setting, Karachi, Pakistan
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Anum, Tariq, Huma, Ali, Farya, Zafar, Ali Akbar, Sial, Kamran, Hameed, Mehwish, Rizvi, Rabia, Bushra, Saima, Salim, Zeb-Un, Nisa, Ghazala R, Naqvi, and Saba, Zubair
- Subjects
Adult ,Male ,Tertiary Healthcare ,Comorbidity ,Length of Stay ,Middle Aged ,Body Mass Index ,Cross-Sectional Studies ,Risk Factors ,Prevalence ,Humans ,Surgical Wound Infection ,Anesthesia ,Female ,Pakistan ,Prospective Studies ,Mortality ,Aged - Abstract
Among the well-known Health care-associated infections (HAIs), surgical site infections (SSIs) contribute to considerable high mortality and morbidity rate, substantial prolongation in hospitalization period and extra expenses in terms of treatment cost. This study was aimed to evaluate the predictive variables associated with surgical site infections, and their clinical consequences. This was a prospective, cross sectional study conducted in the surgical department of tertiary care setting in Karachi, Pakistan. Each patient was followed up from the time of admission until time of the discharge postoperatively for 30 days. A total of 554 surgical procedures were performed and 81 SSIs were identified. The predictor variable/risk factors significantly associated with the presence of SSI were age, gender, BMI, ASA score, co-morbid condition, surgical wound class, emergency surgeries, duration of surgery, type of anesthesia, prosthetic implant, pre operative length of stay and pre operative blood transfusion. Outcomes of such studies may be utilized in the design of a multi factorial practice to get better patient's safety and clinical outcomes.
- Published
- 2018
9. Neuromyotonia: autoimmune pathogenesis and response to immune modulating therapy
- Author
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Hayat, Ghazala R, Kulkantrakorn, Kongkiat, Campbell, William W, and Giuliani, Michael J
- Published
- 2000
- Full Text
- View/download PDF
10. VENTILATOR-ASSOCIATED PNEUMONIA
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Zubair, Saba, primary, Ali, Huma, additional, Zafar, Farya, additional, Raza, Syed Faheem, additional, Ashraf, Irfan, additional, Warind, Javaid, additional, Beg, Anwer Ejaz, additional, Rizvi, Mehwish, additional, Nisa, Zaib-un-, additional, Naqvi, Ghazala R., additional, and Tariq, Anum, additional
- Published
- 2018
- Full Text
- View/download PDF
11. GROWTH RESPONSE OF JUVENILE GRASS CARP (CTENOPHARYNGODON IDELLA) FED ISOCALORIC DIETS WITH VARIABLE PROTEIN LEVELS
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Ghazala, R., Tabinda, A.B., and Yasar, A.
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Diet -- Physiological aspects -- Health aspects ,Company growth ,Biological sciences - Abstract
Byline: R. Ghazala, A. B. Tabinda, and A. Yasar - Email: yasar.abdullah@gmail.com ABSTRACT Sixty days feeding experiment was conducted on grass carp fry fed isocaloric diets with variable protein levels [...]
- Published
- 2011
12. VENTILATOR-ASSOCIATED PNEUMONIA; MICROBIOLOGY, MULTIDRUG RESISTANCE IMPACT AND ASSOCIATED RISK FACTORS IN TERTIARY HOSPITALS SETTINGS.
- Author
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Zubair, Saba, Ali, Huma, Zafar, Farya, Raza, Syed Faheem, Ashraf, Irfan, Warind, Javaid, Ejaz Beg, Anwer, Rizvi, Mehwish, Zaib-un-Nisa, Naqvi, Ghazala R., and Tariq, Anum
- Subjects
VENTILATOR-associated pneumonia ,MULTIDRUG resistance ,MICROBIOLOGY - Abstract
Background: Patients associated with VAP having mortality rates range from 20 to 50% and this may extend up to 70% when multi-resistant and invasive pathogens accountable for infection, however, VAP is also interrelated with noteworthy rate of morbidity, extended period of stay in ICU, protracted MV, and augmented hospitalization cost. Objectives: To review the risk factors, incidence and transience rate of mortality for ventilator-associated pneumonia. Design: Prospective and cross sectional way. Period: From April 2016 to December 2016. Setting: Different Tertiary Care Institutes of Karachi, Pakistan. Method: A structured data collection form was prepared to record the information and validated using spearman correlation coefficient and Cronbach's α value. Value of α = 0.902 and p = 0.913 have revealed the suitable degree of reliability and uniformity. Data was collected with respect to gender, age, antibiotic utilization record, and main diagnosis outcomes. Microbiological basis of ventilator-associated pneumonia was assessed using patient lab record for rate and seclusion of organism. Results: In this study a detail of significant virulence factor articulated by these microorganisms has been depicted. Statistically insignificant differences were observed among the groups with respect to clinical and demographic characteristics like mean age, gender, infection severity scores (SOFA, MODS, CPIS and APACHE II), immune status of patients and type of the cases including surgical or clinical scenario. 39.3% patients developed early onset while 60.6% of cohort was observed with late onset of VAP. Conclusion: The precise microbial source of VAP are numerous and diverse. The realistic challenge at the present time is to portray the authentic approximate of the clinical consequences associated with VAP. Henceforth such investigations may be supportive in origination of the most favorable institutional antimicrobial strategy to reduce the associated complications of this threat. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
13. Drug utilization and prescribing pattern of antibiotics in a tertiary care setups; trends and practices.
- Author
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Ali, Huma, Zafar, Farya, Alam, Shazia, Beg, Anwar Ejaz, Bushra, Rabia, Manzoor, Ammara, Naqvi, Ghazala R., Yasmeen, Riffat, Shafiq, Yousra, Tariq, Anum, Zubair, Saba, and Saleem, Saima
- Abstract
Irrational, over and misuse of antibiotics arise as global concern in both hospital and community settings and lead to adverse events including antimicrobial resistance, associated health problems, amplified hospitalization stay and cost. Hence, Drug Utilization Evaluation (DUE) studies are designed to evaluate and improve the prescribing, administration and the rational use of medications. The present study was designed to assess the pattern of antimicrobial drug utilization in in-patients cohort of tertiary care setup in Karachi, Pakistan. This cross sectional observational study was conducted in retrospective manner. World health organization (WHO) guidelines and criteria are considered to evaluate the appropriateness of drug use in various disease conditions. ATC/DDD system was applied to determine the study outcome. High frequency of antibiotics utilization found in respiratory tract infections of both lower (LRTI) 16.8% (n=42) and upper (UTI) 13.2% (n=33). The estimated total number of drug units administered per month was greater with cefixime (46) and ciprofloxacin (45) both. DDD/100 bed days drug utilization of antibiotics was higher with ciprofloxacin, cefexime and meropenem (47, 46 and 29.25) correspondingly. In conclusion, the current investigation signifies extensive scope for progress in prescribing trend. Drug adherence to customary guidelines of disease management and constraint policies to endorse judicious drug use may be considered vital in healthcare setup. [ABSTRACT FROM AUTHOR]
- Published
- 2018
14. Incidence of drug interactions in intensive care units in tertiary care settings: Classification, facts and measures.
- Author
-
Hasnain, Hina, Ali, Huma, Zafar, Farya, Sial, Ali Akbar, Alam, Shazia, Beg, Anwar Ejaz, Bushra, Rabia, Rizvi, Mehwish, Khan, Maqsood Ahmed, Shareef, Huma, Naqvi, Ghazala R., and Anum Tariq
- Abstract
Drug-drug interactions (DDIs) are extremely significant concern, particularly in sensitive population including pediatric and geriatric. Propensity for the development of DDIs is high in patients admitted at intensive care units (ICU). This study was conducted to evaluate the DDIs incidence, facts and measures in ICU. From a total of 150 cases studied for ICU patients, with the mean age of 56.37±12.45 years, 55.33% were male and the rest were female 44.66%. The demographic information like age, gender and main diagnosis details of study participants that were extracted from the patients' clinical record. A statistically significant association between the drug interaction and the number of drugs prescribed per prescription was observed (p<0.0001). Concerning the onset of outcome, 52% of DDIs distinguished as delayed onset of effect (past 24 hours) and 35% were categorized as rapid onset (within 24 hours). Despite the facts regarding patient safety and minimizing DIs error, polypharmacy is still frequent in critically ill patients admitted in ICU attributed high risk of adverse reactions due to use of multiple interventions to treat severity of disease condition. Such studies may be used to develop an effective tool for the diagnosis and management of DDIs. [ABSTRACT FROM AUTHOR]
- Published
- 2018
15. Assessment of predictor variables and clinical consequences associated with surgical site infection in tertiary care setting, Karachi, Pakistan.
- Author
-
Tariq, Anum, Ali, Huma, Zafar, Farya, Sial, Ali Akbar, Hameed, Kamran, Rizvi, Mehwish, Bushra, Rabia, Salim, Saima, Zeb-Un-Nisa, Naqvi, Ghazala R., and Zubair, Saba
- Abstract
Among the well-known Health care-associated infections (HAIs), surgical site infections (SSIs) contribute to considerable high mortality and morbidity rate, substantial prolongation in hospitalization period and extra expenses in terms of treatment cost. This study was aimed to evaluate the predictive variables associated with surgical site infections, and their clinical consequences. This was a prospective, cross sectional study conducted in the surgical department of tertiary care setting in Karachi, Pakistan. Each patient was followed up from the time of admission until time of the discharge postoperatively for 30 days. A total of 554 surgical procedures were performed and 81 SSIs were identified. The predictor variable/risk factors significantly associated with the presence of SSI were age, gender, BMI, ASA score, co-morbid condition, surgical wound class, emergency surgeries, duration of surgery, type of anesthesia, prosthetic implant, pre operative length of stay and pre operative blood transfusion. Outcomes of such studies may be utilized in the design of a multi factorial practice to get better patient's safety and clinical outcomes. [ABSTRACT FROM AUTHOR]
- Published
- 2018
16. Neurologic deficit in patients at high risk with thoracoabdominal aortic aneurysms: the role of cerebral spinal fluid drainage and distal aortic perfusion
- Author
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Victor M. Rivera, Harold K. Doerr, Hazim J. Safi, Ghazala R. Butt, Robert Maulsby, Stefano Bartoli, Roy Sheinbaum, Joseph R. Viets, Kenneth R. Hess, and Salwa S. Shenaq
- Subjects
Adult ,Male ,medicine.medical_specialty ,Aneurysm ,Postoperative Complications ,Risk Factors ,medicine.artery ,medicine ,Thoracic aorta ,Humans ,Prospective Studies ,Survival rate ,Aged ,Aortic dissection ,Aged, 80 and over ,Postoperative Care ,Intraoperative Care ,Aortic Aneurysm, Thoracic ,business.industry ,Vascular disease ,Incidence ,Abdominal aorta ,Perioperative ,Infusion Pumps, Implantable ,Middle Aged ,medicine.disease ,Constriction ,Cerebrospinal Fluid Shunts ,Surgery ,Survival Rate ,Aortic Dissection ,Anesthesia ,Multivariate Analysis ,Reperfusion ,Drainage ,Regression Analysis ,Female ,Nervous System Diseases ,Cardiology and Cardiovascular Medicine ,business ,Intercostal arteries ,Aortic Aneurysm, Abdominal - Abstract
Purpose: This prospective study evaluated the possible prevention of postoperative neurologic deficit in patients at high risk with thoracoabdominal aortic aneurysms (TAAA), types I and II, by use of perioperative cerebrospinal fluid drainage and distal aortic perfusion. Methods: Between September 18, 1992, and August 8, 1993, 45 consecutive patients underwent TAAA repair (14 type I, 31 type II). Thirty-six were men and nine were women. The median age was 63 years (range 28 to 88). Twenty-four of 45 patients (53%) had dissection and 17 of 45 (38%) had prior proximal aortic replacement. All patients underwent perioperative cerebrospinal fluid drainage and distal aortic perfusion. Median aortic clamping time was 42 minutes. Thirty-five of 45 patients (78%) underwent intercostal artery reattachment. Results: The 30-day survival rate was 96% (43 of 45 patients). Early neurologic deficit occurred in two of 45 patients (4%), and late neurologic deficit also occurred in two of 45 patients (4%). We compared the neurologic deficit of our current group of 45 patients with the data of a previously unpublished study of 112 patients also from this center. Total neurologic deficit for the current group was four of 45 (9%) versus the previous group of 35 of 112 (31%) with a p value of 0.0034 (Pearson chi-square test). Neurologic deficit for patients with type I TAAA was 0 of 14 (0%) versus 15 of 73 (21%) (p = 0.062); for patients with type II TAAA 4 of 31 (13%) versus 20 of 39 (51%) (p = 0.0008). In patients with aortic dissection, neurologic deficit was 3 of 24 (12%) versus 9 of 32 (28%) (p = 0.0304); no dissection was 1 of 21 (5%) versus 26 of 80 (32%) (p = 0.011). For aortic clamp times less than 45 minutes, neurologic deficit was 1 of 24 (4%) versus 14 of 68 (21%) (p = 0.061); for aortic clamp times equal to or greater than 45 minutes, neurologic deficit was 3 of 21 (14%) versus 21 of 44 (48%) (p = 0.0090). Conclusion: Neurologic deficit in patients treated for types I and II TAAA was reduced significantly by perioperative cerebral spinal fluid drainage and distal aortic perfusion. (J VASC SURG 1994;20:434-43.)
- Published
- 1994
17. A role for functional classification in the early identification of prognostic factors in ALS
- Author
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Rauchway, Amy C., primary, Kaiboriboon, Kitti, additional, Bansal, Sachin K., additional, Kulkantrakorn, Kongkiat, additional, Guo, Xiaoyan, additional, Parks, Becky Jo, additional, and Hayat, Ghazala R., additional
- Published
- 2007
- Full Text
- View/download PDF
18. Cauda Equina and Conus Medullaris Syndrome in Sarcoidosis
- Author
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Kaiboriboon, Kitti, primary, Olsen, Thomas J., additional, and Hayat, Ghazala R., additional
- Published
- 2005
- Full Text
- View/download PDF
19. Parental Ferric Hydroxide Saccharate Therapy for Iron Deficiency Anemia: Safety and Efficacy
- Author
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Ali A. Bajouda, Ghazala R. Radwi, Hikmat Abdel-Razeq, Marifi Macalintal, and Manar M I Khalil
- Subjects
medicine.medical_specialty ,Pregnancy ,Malabsorption ,business.industry ,Anemia ,Immunology ,Cell Biology ,Hematology ,Iron deficiency ,medicine.disease ,Biochemistry ,Gastroenterology ,Surgery ,Iron-deficiency anemia ,Internal medicine ,Palpitations ,Medicine ,Hemoglobin ,medicine.symptom ,business ,Adverse effect - Abstract
Background: Iron deficiency remains the most common cause of anemia both locally and worldwide. In adults, the most common etiology of iron deficiency is blood loss; in men and postmenopausal women, iron deficiency almost inevitably signifies gastrointestinal (GI) blood loss. In women of childbearing age, genitourinary blood loss is the usual culprit. The goal of iron therapy for iron deficiency anemia (IDA) is to supply sufficient iron to repair the hemoglobin deficit and replenish storage iron. Iron can be given in either oral or parenteral forms. Because of the local and systemic side effects linked to parenteral iron therapy, it has been the less favored form of treatment of IDA. In this retrospective review, we report our experience using parenteral iron therapy for certain indications in patients with severe IDA. Methods: Total number of patients was 57, 54 were females. Mean age was 31 years (12–60 yrs). Iron deficiency anemia was found to be due to: menorrhagia (46%), pregnancy (23%), malabsorption (22%), GI loss (7%) and poor dietary habits (4%). Patients presented with the following symptoms: dizziness (84%), exertional dyspnea (40%), palpitations (28%) and fatigue (23%). The indications for parenteral iron therapy were: severe symptomatic anemia (58%), pregnancy (25%), poor response to oral iron (14%), noncompliance to oral therapy (10%) and bleeding (7%). Treatment plan: The form of iron used was Ferric Hydroxide Saccharate Complex. Iron requirement was calculated based on the following formula: Total iron deficiency in mg = [body weight (kg) x (normal Hb -actual Hb in g/L)x 0.24] + 500.The mean iron requirement was 1200mg (700mg – 2400mg). This was given in an outpatient setting as daily intravenous infusions starting with a dose of 100mg on the first day. The rest of the requirement was divided into doses of 200mg given over consecutive days. Results: The mean Hb pre-treatment was 7.96g/dL (4.9–10.7g/dL) and the mean Hb post treatment was 10.6g/dL. (8.2–12.3g/dL). The rise in Hb was at a rate of 0.76/dL per week (0.17– 1.9). All patients tolerated the treatment well with only one complaining of burning sensation at the site of the IV line. There were no other side effects including anaphylactic reactions. In conclusion, the above data demonstrates that parenteral iron therapy, in the form and schedule given, is a fast, convenient, effective and safe means of treating severe, symptomatic IDA.
- Published
- 2004
- Full Text
- View/download PDF
20. Vecuronium-associated axonal motor neuropathy: a variant of critical illness polyneuropathy?
- Author
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Geller, Thomas J, primary, Kaiboriboon, Kitti, additional, Fenton, Glen A, additional, and Hayat, Ghazala R, additional
- Published
- 2001
- Full Text
- View/download PDF
21. Solitary Intramedullary Neurosarcoidosis: Role of MRI in Early Detection
- Author
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Hayat, Ghazala R., primary, Walton, Timothy P., additional, Smith, Kenneth R., additional, Martin, David S., additional, and Manepalli, Anantha N., additional
- Published
- 2001
- Full Text
- View/download PDF
22. Toxoplasmic polymyositis revisited: case report and review of literature
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Cuturic, Miroslav, primary, Hayat, Ghazala R., additional, Vogler, Carole A., additional, and Velasques, Alvaro, additional
- Published
- 1997
- Full Text
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23. Unexpected recovery in a newborn with severe hypomyelinating neuropathy
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Levy, Beth K, primary, Fenton, Glen A, additional, Loaiza, Sergio, additional, and Hayat, Ghazala R, additional
- Published
- 1997
- Full Text
- View/download PDF
24. Neurologic deficit in patients at high risk with thoracoabdominal aortic aneurysms: The role of cerebral spinal fluid drainage and distal aortic perfusion
- Author
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Safi, Hazim J., primary, Bartoli, Stefano, additional, Hess, Kenneth R., additional, Shenaq, Salwa S., additional, Viets, Joseph R., additional, Butt, Ghazala R., additional, Sheinbaum, Roy, additional, Doerr, Harold K., additional, Maulsby, Robert, additional, and Rivera, Victor M., additional
- Published
- 1994
- Full Text
- View/download PDF
25. UTILIZATION OF CHICKEN INTESTINE AS AN ALTERNATIVE PROTEIN SOURCE IN THE DIET FOR FINGERLINGS OF CIRRHINUS MIRIGALA.
- Author
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Tabinda, A. B., Ghazala, R., Yasar, A., and Ashraf, M.
- Subjects
- *
PROTEINS in animal nutrition , *FEED utilization efficiency , *INTESTINAL proteins , *INFANCY of fishes , *FISH growth , *CHICKENS , *CARP , *FISH meal - Abstract
Suitability of chicken intestine as an alternate protein source was evaluated for the diet of Cirrhinus mirigala fingerlings. Percentage protein, fat, ash, fiber, moisture and available energy (Kcal/100g) for the experimental diets were analyzed. Five experimental diets were formulated with chicken intestine meal 0% (FM[sub 100] Control), 25% (FM75), 50% (FM50), 75% (FM25) and 100% (FM0) substituting 0, 25, 50, 75, and 100% of the fish meal (FM) respectively. FM100 served as control diet. Experimental diets were iso-nitrogenous, iso-lipidic and iso-energic with 40% protein, 7.7-8.7% lipid and 425-446kcal energy per 100g diet. Sixtey days feeding trial experiment was performed in static indoor conditions. FM75 had almost similar growth as compared to control (FM100) in Cirrhinus mirigala fingerlings diets. Significantly higher growth was recorded in FM50 as compared to FM100 (control) and FM75. Present study showed overall significantly higher growth in FM25 (P<0.01) and FM0 (P<0.05) as compared to the control. Lowest feed conversion ratio was observed in higher growth dietary treatments and vice versa. The results of the present study concluded that although best growth was achieved in the dietary treatment FM25 but without compromising growth 100% chicken intestine could be substituted for fish meal without addition of amino acids in Cirrhinus mirigala fingerlings diet. [ABSTRACT FROM AUTHOR]
- Published
- 2013
26. Partial trisomy 1q25----qter.
- Author
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Tawn, E J, primary, Roberts, M B, additional, Ghazala, R G, additional, and Pyta, E M, additional
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- 1986
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27. Mitochondrial DNA copy number in Hepatitis C virus-related chronic liver disease: impact of direct-acting antiviral therapy.
- Author
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Elyamany A, Ghazala R, Fayed O, Hamed Y, and El-Shendidi A
- Subjects
- Humans, Antiviral Agents therapeutic use, Hepacivirus genetics, DNA, Mitochondrial genetics, DNA, Mitochondrial analysis, DNA Copy Number Variations, Mitochondria genetics, Mitochondria chemistry, Hepatitis C, Chronic drug therapy, Hepatitis C, Chronic genetics, Hepatitis C, Chronic complications, Hepatitis C drug therapy
- Abstract
Hepatitis C virus (HCV) infection can regulate the number and dynamics of mitochondria, and is associated with a prominent hepatic mitochondrial injury. Mitochondrial distress conveys oxidative damage which is implicated in liver disease progression. The present study was conducted to assess the change of mitochondrial DNA (mtDNA) copy number in patients with HCV-related chronic liver disease and the impact of direct-acting antiviral (DAA) therapy. Whole blood mtDNA copy number was measured using real-time quantitative polymerase chain reaction at baseline and 12 weeks after the end of therapy in 50 treatment-naïve HCV-infected patients who achieved sustained viral response (SVR) after DAA therapy and 20 healthy controls. Whole blood mtDNA copy number appeared significantly lower in HCV-infected patients before therapy compared to healthy subjects (P < 0.001). Post-treatment, there was significant increase of mtDNA copy number in HCV-infected patients at SVR12 compared to the pre-treatment values (P < 0.001), meanwhile it didn't differ significantly between HCV-infected patients after therapy and healthy subjects (P = 0.059). Whole blood mtDNA copy number correlated inversely to the serum bilirubin in HCV-infected patients (P = 0.013), however it didn't correlate significantly to the serum aminotransferases, viral load or fibrosis-4 score (P > 0.05). In conclusion, chronic HCV infection has been associated with a prominent mitochondrial injury which could mediate a progressive liver disease. The improved mtDNA content after DAA therapy highlights a possible potential of these drugs to alleviate mitochondrial damage in HCV-related liver disease., (© 2023. The Author(s).)
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- 2023
- Full Text
- View/download PDF
28. Circulating HOTAIR potentially predicts hepatocellular carcinoma in cirrhotic liver and prefigures the tumor stage.
- Author
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El-Shendidi A, Ghazala R, and Hassouna E
- Abstract
Aim of the Study: Homeobox transcript antisense intergenic RNA (HOTAIR) is a long non-coding RNA classified as an oncogene and has been implicated in liver cancer initiation and progression. This study investigated the clinical usefulness of serum HOTAIR to predict hepatocellular carcinoma (HCC) and prefigure the tumor stage., Material and Methods: This study included 80 patients with de novo HCC divided into 40 late-stage HCC patients (group IA) and 40 early-stage HCC patients (group IB), 40 patients with non-tumorous liver cirrhosis (group II), and 20 healthy controls (group III). Serum HOTAIR was measured using real-time quantitative polymerase chain reaction. Serum α-fetoprotein (AFP) was measured via enzyme-linked immunosorbent assay., Results: Serum HOTAIR was significantly higher in groups IA, IB and II compared to healthy subjects. Serum HOTAIR was significantly higher in group IA than group IB, and in groups IA and IB compared to group II. Serum HOTAIR at cut-off value > 15.45 (AUC = 0.71) showed 66% sensitivity and 78% specificity in discriminating HCC patients of group IB from HCC patients of group IA. When combined with AFP, the discriminative sensitivity and specificity increased to 74% and 90% respectively (AUC = 0.85). Serum HOTAIR at cut-off value > 9.42 (AUC = 0.823) showed 67.5% sensitivity and 93.3% specificity in discriminating HCC patients of group IB from patients with non-tumorous cirrhotic liver. When combined with AFP, the discriminative sensitivity and specificity increased to 80% and 98.3% respectively (AUC = 0.954)., Conclusions: Circulating HOTAIR is a potential biomarker which may be used solely, or preferably in combination with AFP, to help HCC detection in cirrhotic liver and prefigure the tumor stage., Competing Interests: The authors declare no conflict of interest., (Copyright © 2022 Clinical and Experimental Hepatology.)
- Published
- 2022
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29. Awareness, anxiety, and depression in healthcare professionals, medical students, and general population of Pakistan during COVID-19 Pandemic: A cross sectional online survey.
- Author
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Muhammad Alfareed Zafar S, Junaid Tahir M, Malik M, Irfan Malik M, Kamal Akhtar F, and Ghazala R
- Abstract
Background: COVID-19 (coronavirus disease 2019) pandemic has seriously affected the entire world. This study was aimed to assess prevalence and influencing factors of anxiety and depression during the pandemic in our Pakistani population, including healthcare professionals, undergraduate medical students, and general public. Methods: An online cross sectional survey was conducted; with a questionnaire having demographic profile, COVID-19-related knowledge/awareness, self-rating anxiety scale (SAS), and self-rating depression scale (SDS). A total of 1014 people responded to the survey. Chi square test was used to compare different groups, and logistic regression models were used to explore influencing factors for anxiety and depression symptoms. Results: Of the 1014 respondents, 92.6% were aware of COVID-19, and the prevalence rate of anxiety and depression symptoms was 4.6% and 14.3%, respectively. Healthcare professionals had more awareness about COVID-19 as compared to medical students and general public (p<0.001). Logistic regression models showed females, and people who were not aware of COVID-19 (≤ 6 points score) were more likely to have both anxiety and depression symptoms (p<0.05), the general public had more anxiety than healthcare professionals (p<0.05), while undergraduate medical students and young people had only depression (p<0.05). Conclusion: Although major mental health burden is not present in Pakistan, but there is a dire need to pay more attention to vulnerable groups like young people, undergraduate medical students, and women. Psychological interventions are required to reduce the psychological impact of COVID-19 pandemic., Competing Interests: Conflicts of Interest: None declared, (© 2020 Iran University of Medical Sciences.)
- Published
- 2020
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30. Drug utilization evaluation of Piperacillin/Tazobactam: A prospective and cross sectional investigation in tertiary care setup.
- Author
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Korai U, Naqvi GR, Zafar F, Ali H, Naeem S, Alam N, Saeed R, Farooqi S, and Hussain T
- Subjects
- Adult, Aged, Aged, 80 and over, Cross-Sectional Studies, Drug Therapy, Combination methods, Drug Utilization, Drug Utilization Review, Female, Humans, Male, Middle Aged, Prospective Studies, Tertiary Healthcare, Young Adult, Anti-Bacterial Agents therapeutic use, Piperacillin, Tazobactam Drug Combination therapeutic use
- Abstract
Drug utilization evaluation (DUE) is an arrangement of continuous, orderly, criteria-based assessment of medication utilizes to guarantee that medicines are utilized suitably. In the event that treatment is regarded to be improper, provider and patient intervention may be important to optimize therapeutic efficacy. In the present study drug utilization evaluation of Piperacillin/Tazobactam was carried out in prospective manner. A well structured data collection form was constructed to collect the related information regarding demographic, clinical use, indication, culture sensitivity criteria, outcomes of therapy, renal impairment cases of dose adjustments and appropriate use. Results of chi square indicated insignificant relationship between gender and as p value was found to be p=0.446 and 0.111 for use of drug alone and in combination. Similarly insignificant relationship between gender and use of drug in combination with other antibiotics as p value was found to be p=0.111. It was found that from 61-70 years (Therapeutic Effectiveness; n=12, 9.37%), (Therapeutic Failure; n=10, 45.45%) and mortality (n=1, 50%) were quite higher. The prescription pattern was in accordance with standard guidelines. Study indicated need to elevate prescribers to pursue generic prescribing and rationally utilize antibiotics to avert advancement of resistance at the level of hospital and community. These sorts of studies are valuable for acquiring data about medication utilize designs and for recognizing inconceivable expense of medicines.
- Published
- 2019
31. Duration of anticoagulation after first episode of unprovoked venous thromboembolism.
- Author
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Abdel-Razeq HN and Radwi GR
- Subjects
- Adult, Humans, Long-Term Care, Randomized Controlled Trials as Topic, Risk Factors, Secondary Prevention, Thromboembolism etiology, Treatment Outcome, Venous Thrombosis etiology, Anticoagulants administration & dosage, Thromboembolism drug therapy, Venous Thrombosis drug therapy, Warfarin administration & dosage
- Published
- 2004
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