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569 results on '"Ghazanfari, Tooba"'

19. Relationship between Diet-Related Inflammation and Hospitalization Risk and Disease Severity in Patients with COVID-19.

Author

Yari, Zahra, Ebrahimof, Samira, Soltanieh, Samira, Salavatizadeh, Marieh, Karimi, Sara, Ardestani, Sussan K., Salehi, Mohammadreza, Jahromi, Soodeh Razeghi, Ghazanfari, Tooba, and Hekmatdoost, Azita

Subjects
COVID-19, DIETARY patterns, INFLAMMATION, BIOMARKERS, CROSS-sectional method
Abstract

Background: Increased serum concentrations of inflammatory biomarkers in patients indicate a strong association between COVID-19 and inflammation. However, the association between diet-related inflammation and COVID-19 has been less investigated. The aim of this study is to investigate whether the inflammatory scores of the diet are associated with the severity of COVID-19 disease and the probability of hospitalization of patients. Methods: The authors conducted a cross-sectional study involving 141 patients with COVID-19. The empirical dietary inflammatory pattern (EDIP) and dietary inflammation scores (DIS) were calculated based on a 147-item semiquantitative food frequency questionnaire. The association between serum levels of inflammatory biomarkers and diet-related inflammation was also investigated. Results: 74 inpatients and 87 outpatients participated in this study. Higher DIS scores were significantly associated with an increased risk of COVID-related hospitalization (Tertile3 vs. tertile1: OR = 3·62; 95 % CI 1·43 to 9·14, P=0·008 after fully adjustment). This association with EDIP was also observed, but it was not significant. Conclusion: The data from this provide evidence that a pro-inflammatory diet was associated with higher risk of hospitalization due to high severity of COVID-19. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Mesenchymal Stem Cell Therapy Mitigates Acute and Chronic Lung Damages of Sulfur Mustard Analog Exposure.

Author

Tapak, Mahtab, Sadeghi, Somaye, Ghazanfari, Tooba, Mosaffa, Nariman, Mirsanei, S. Zahra, and Masiha Hashemi, Seyed Mahmoud

Subjects
MUSTARD gas, TREATMENT effectiveness, MESENCHYMAL stem cells, STEM cell treatment, ENZYME-linked immunosorbent assay
Abstract

Sulfur mustard (SM) is an established chemical weapon that can result in severe damage to parts of the body. Currently, there are no effective treatments available for SM-caused damage. We aimed to investigate the therapeutic potential of adipose-derived mesenchymal stromal cells (AD-MSCs) and conditioned medium (CM-MSCs) in acute and chronic pulmonary mouse models caused by 2- chloroethyl ethyl sulfide (CEES), an SM analog. The mice were divided into 4 experimental groups:(1) CEES+AD-MSCs, (2) CEES+CMMSCs, (3) CEES, and (4) control. The model observation time was divided into 7 days for the short and 6 months for the long term. AD-MSCs were injected into mice via intraperitoneal injection 24 hours after CEES exposure. The therapeutic effects of AD-MSCs on pulmonary tissue damage were assessed using a histopathologic assay, measuring the neutrophil count, and bronchial alveolar lavage fluid (BALF) protein level. The levels of inflammatory and anti-inflammatory cytokines were evaluated using the enzyme-linked immunosorbent assay as the outcomes of interest. Lung damage progression was reduced by AD-MSC treatment in mice after CEES injection into the peritoneum. The proportion of CD11b+F4/80+ macrophages in the peritoneum was significantly lowered by AD-MSC treatment following CEES exposure. AD-MSC administration also reduced the level of pro-inflammatory cytokines, BALF protein, and nitric oxide levels in the peritoneal cavity. By reducing inflammation and enhancing tissue healing, AD-MSCs and CM-MSC help prevent acute lung damage caused by CEES. The current study supports the use of a mouse model as a solid experimental foundation and indicates potential use for future cell treatment. [ABSTRACT FROM AUTHOR]

Published
2024
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29. Alteration in inflammatory mediators in seriously eye-injured war veterans, long-term after sulfur mustard exposure

Author

Ghasemi, Hassan, Javadi, Mohammad Ali, Ardestani, Sussan K., Mahmoudi, Mahmoud, Pourfarzam, Shahryar, Mahdavi, Mohammad Reza Vaez, Yarmohammadi, Mohammad Ebrahim, Baradaran-Rafii, Alireza, Jadidi, Khosro, Shariatpanahi, Shamsa, Rastin, Maryam, Heidary, Fatemeh, Safavi, Maliheh, Mirsharif, Ensie Sadat, Nasiri, Zahra, and Ghazanfari, Tooba

Published
2020
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42. Plant-based diet and COVID-19 severity: results from a cross-sectional study

Author

Soltanieh, Samira, primary, Salavatizadeh, Marieh, additional, Ghazanfari, Tooba, additional, Jahromi, Soodeh Razeghi, additional, Yari, Zahra, additional, Mansournia, Mohammad Ali, additional, Nazemipour, Maryam, additional, Kheradmand, Jalil Arab, additional, Ardestani, Sussan K, additional, Karimi, Sara, additional, and Hekmatdoost, Azita, additional

Published
2023
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48. BVVL/ FL: features caused by SLC52A3 mutations; WDFY4 and TNFSF13B may be novel causative genes

Author

Khani, Marzieh, Shamshiri, Hosein, Taheri, Hanieh, Hardy, John, Bras, Jose Tomas, Carmona, Susana, Moazzeni, Hamidreza, Alavi, Afagh, Heshmati, Ali, Taghizadeh, Peyman, Nilipour, Yalda, Ghazanfari, Tooba, Shahabi, Majid, Okhovat, Ali Asghar, Rohani, Mohammad, Valle, Giorgio, Boostani, Reza, Abdi, Siamak, Eshghi, Shaghayegh, Nafissi, Shahriar, and Elahi, Elahe

Published
2021
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49. Comparison of culture and PCR-DGGE methods to evaluate the airways of cystic fibrosis patients and determination of their antibiotic resistance profile.

Author

Goudarzi, Somayeh Moazami, Arani, Yasamin Shahpouri, Ali, Ahya Abdi, Mohammadi, Parisa, Ghorbanmehr, Nassim, Modaresi, Mohammadreza, Movahed, Mahtab Ghorban, and Ghazanfari, Tooba

Subjects
DRUG resistance in bacteria, CYSTIC fibrosis, CROSS-cultural studies, ACHROMOBACTER, BACTERIAL diversity, STENOTROPHOMONAS maltophilia
Abstract

Background and Objectives: Respiratory infections are the most serious condition in cystic fibrosis (CF) patients; therefore, a thorough comprehension of the diversity and dominant microbial species in CF airways has a crucial role in treatment. Our objective was to determine the antibiotic resistance profile of CF airways microbiota and compare culture methods and PCR-DGGE to evaluate bacterial diversity. Materials and Methods: Pharyngeal swabs from 121 CF patients were collected. The samples were then cultured, identified and antibiotic resistance testing was performed. Thirty samples were subjected to further molecular surveys. DNA contents of these samples were extracted and amplified using nested-PCR technique and their bacterial diversity was assessed by DGGE. The DGGE patterns were visualized and certain bands were excised and purified. Next, the DNA was amplified by another round of PCR and sent out for sequencing. Results: Staphylococcus aureus, Pseudomonas aeruginosa, and Klebsiella pneumoniae were the most prevalent species isolated using culture methods. S. aureus was the most common bacteria among 6 years and younger patients; while, P. aeruginosa had more prevalence among older ones. The PCR-DGGE results showed more diversity than culture methods, particularly in younger patients who exhibited more bacterial diversity than the older groups. Sequencing results unveiled the presence of certain bacterial species including Haemophilus parainfluenzae and Stenotrophomonas maltophilia which were completely missed in culture. Conclusion: Even though culture-dependent methods are cost-effective, PCR-DGGE appeared to be more efficient to determine bacterial diversity. PCR-DGGE detects less abundant species, though their viability could not be determined using this method. [ABSTRACT FROM AUTHOR]

Published
2023

50. Changes in hormones, Leukocyte Telomere Length (LTL), and p16INK4a expression in SM-exposed individuals in favor of the cellular senescence.

Author

Ardestani, Susan K., Jamali, Tahereh, Taravati, Ali, Behboudi, Hossein, Vaez-Mahdavi, Mohamad-Reza, Faghihzadeh, Elham, and Ghazanfari, Tooba

Subjects
CELLULAR aging, GENE expression, LONGEVITY, P16 gene, CHEMICAL warfare agents, TELOMERES, MUSTARD gas
Abstract

Sulfur mustard (SM) is a chemical warfare agent with well-known severe toxic effects and may cause long-term debilitating injuries. We aimed to evaluate aging and longevity in Iranian SM-exposed survivors using some endocrine and molecular biomarkers for the first time. Dehydroepiandrosterone (DHEA), prolactin (PRL), cortisol, testosterone, and luteinizing hormone (LH) were measured in 289 male SM-veterans and 66 age-matched males using the ELISA method. Leukocyte Telomere Length (LTL) measurement and p16INK4a expression were measured in the peripheral blood leukocytes of 55 males who were exposed to SM. We found a significantly lower serum DHEAS level and higher serum PRL level in SM-exposed groups (without any related to the severity of lung injuries) compared to healthy controls, but no significant difference in serum levels of cortisol, testosterone, and LH. The molar ratio of DHEAS/cortisol was significantly higher in controls compared to the SM-exposed individuals especially those with severe lung damage. Some biological parameters of allostatic load score such as DHEAS and DHEAS/cortisol ratio significantly decreased long-term after the SM exposure. Additionally, we found that LTL was shorter in SM-exposed veterans rather than unexposed controls while p16INK4a gene expression significantly increased in these groups. It seems that DHEAS, DHEAS/cortisol ratio, LTL, and p16INK4a gene expression have changed significantly in favor of cellular senescence in SM-exposed patients. Therefore, it seems that SM exposure increases biological age compared to chronological age in SM-exposed survivors. [ABSTRACT FROM AUTHOR]

Published
2023
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