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Your search keyword '"Ghofrani, Mahdieh"' showing total 4 results
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4 results on '"Ghofrani, Mahdieh"'

3. Improving the in-vivo biological activity of fingolimod loaded PHBV nanoparticles by using hydrophobically modified alginate

Author

Rezaie Shirmard, Leila, primary, Ghofrani, Mahdieh, additional, Bahari Javan, Nika, additional, Bayrami, Samane, additional, Tavassoli, Abdollah, additional, Rezaie, Amir, additional, Amini, Mohsen, additional, Kebriaee-zadeh, Abbas, additional, Rouini, Mohammad-Reza, additional, Dinarvand, Rassoul, additional, Rafiee-Tehrani, Morteza, additional, and Dorkoosh, Farid Abedin, additional

Published
2020
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4. Development of Octreotide-loaded chitosan and heparin nanoparticles: evaluation of surface modification effect on physicochemical properties and macrophage uptake

Author

Pouya Dehghankelishadi, Farid Abedin Dorkoosh, Mohsen Amini, Leila Rezaie Shirmard, Mahdieh Ghofrani, Ghofrani, Mahdieh, Shirmard, Leila Rezaie, Dehghankelishadi, Pouya, Amini, Mohsen, and Dorkoosh, Farid A

Subjects
inorganic chemicals, Chemical structure, Primary Cell Culture, Pharmaceutical Science, Nanoparticle, 02 engineering and technology, Polyethylene glycol, Octreotide, 030226 pharmacology & pharmacy, Polyethylene Glycols, Chitosan, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Drug Stability, mental disorders, PEG ratio, Zeta potential, Animals, Humans, Particle Size, Fluorescein, Cells, Cultured, health care economics and organizations, Drug Carriers, Heparin, technology, industry, and agriculture, respiratory system, 021001 nanoscience & nanotechnology, chemistry, Acromegaly, Macrophages, Peritoneal, Nanoparticles, Surface modification, 0210 nano-technology, Half-Life, Nuclear chemistry
Abstract

Octreotide (OCT) is a therapeutic peptide which is administered for the treatment of acromegaly. The purpose of this study was to design a new polyethylene glycol (PEG)–conjugated nanoparticle (PEG-NP) to overcome the short half-life and poor stability of OCT. The developed PEG-NPs were compared with non-PEGylated NPs with respect to their size, morphological characteristics, loading efficiency, release profile, and macrophage uptake. The OCT-loaded NPs and PEG-NPs were prepared by ionic complexion of chitosan (Cs) with either heparin (Hp) or PEGylated heparin (PEG-Hp). The chemical structure of PEG-Hp was confirmed by IR and proton nuclear magnetic resonance. Morphological analyses by scanning electron microscopy showed that NPs and PEG-NPs have a uniform shape. Dynamic laser scattering measurements indicated that hydrodynamic diameter of NPs and PEG-NPs were 222.5 ± 10.0 nm and 334.9 ± 6.7 nm, respectively. NPs and PEG-NPs had a positive zeta potential of about 32.5 ± 1.1 mv and 20.6 ± 2.4 mv, respectively. Entrapment efficiency was 61.4 ± 1.0% and 55.7 ± 2.4% for NPs and PEG-NPs, respectively. Compared with the NPs, the PEG-NPs exhibited a slower release profile. Subsequently, fluorescein isothiocyanate–labeled chitosanCs was synthesized and used to evaluate the stealth characteristic of PEG-NPs. In vitro macrophage uptake of fluorescently labeled NPs was measured by flow cytometry.

Published
2019

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