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Chiral self‐sorting during the formation of cage‐like molecules continues to fascinate and advance our understanding of the phenomenon in general. Herein, we report the chiral self‐sorting in the Pd6L12‐type metal‐organic cages. When a racemic mixture of axially chiral bis‐pyridyl ligands undergo coordination‐driven self‐assembly with Pd(II) ions to form Pd6L12‐type cages, the system has the option of chiral self‐sorting to afford any of at least 70 pairs of (one homochiral and 69 heterochiral) enantiomers and 5 meso isomers or a statistical mixture of everything. However, the system resulted in diastereoselective self‐assembly through a high‐fidelity chiral social self‐sorting to form a racemic mixture of D3 symmetric heterochiral [Pd6(L6R/6S)12]12+/[Pd6(L6S/6R)12]12+ cages. [ABSTRACT FROM AUTHOR]

When a racemic mixture of chiral building blocks self‐assembles to form discrete molecular or supramolecular cages, the system can adopt either social or narcissistic chiral self‐sorting. However, control over such chiral self‐sorting is hard to achieve with a desired choice of outcome. Herein, we report anion templated high‐fidelity chiral self‐sorting during the coordination‐driven self‐assembly of [Pd2L4] metal‐organic cages, with a racemic mixture of an axially chiral ligand. Upon varying the counter‐anions, the outcome of the choice of chiral self‐sorting, whether social or narcissistic, leading to kinetically favored heterochiral or thermodynamically favored homochiral cages, can be controlled through specific anion encapsulation. Non‐encapsulating anion afforded a mixture of all possible diastereomers. Anion exchange enabled structural transformations between the diastereomers and the conversion of the mixture of diastereomers into homochiral diastereomers. [ABSTRACT FROM AUTHOR]

This work reports chiral social self-sorting in the diastereoselective self-assembly of Pd SB 6 sb L SB 12 sb metal-organic cages with a racemic mixture of axially chiral bis-pyridyl ligand with Pd(II) ions. Chiral self-sorting, chirality, coordination-driven self-assembly, metal-organic cages, self-assembly Keywords: chiral self-sorting; chirality; coordination-driven self-assembly; metal-organic cages; self-assembly EN chiral self-sorting chirality coordination-driven self-assembly metal-organic cages self-assembly 1 1 1 04/19/23 20230417 NES 230417 B The origin of chiral self-sorting b in the building blocks of life remains a fundamental question. [Extracted from the article]

Polycyclic aromatic hydrocarbons (PAHs) are carcinogenic and persistent organic pollutants in water. Their removal is highly challenging for existing generic and nonspecific adsorbents, creating an urgent need for tailored solutions. Herein, a metal-"organic cage" framework, MOF-CC-1, designed for the effective scavenging of PAHs from water is is introduced. This framework is constructed using a propeller-shaped cofacial organic cage (CC-1), equipped with three triazole pillars that coordinate with Ag(I) ions. The cationic MOF-CC-1 adopts a chiral (10,3)-a srs net structure, spontaneously resolving into homochiral crystals. Additionally, bulk homochirality is achieved through chirality induction using chiral counteranions. MOF-CC-1 uniquely encapsulates diverse PAH molecules within the cavities of CC-1, as confirmed by single-crystal X-ray diffraction, marking it as the first metal-"organic cage" framework with structural evidence of guest inclusion inside the organic cage linker. Further, MOF-CC-1 exhibits soft porosity, remaining nonporous to N₂ gas when compressed but expanding to encapsulate PAHs in solution. Moreover, MOF-CC-1 exhibits exceptional efficacy in scavenging ppb levels of PAHs from water. This work represents a significant advancement in utilizing organic cages as ligands toward MOF construction, paving the way for tailored adsorbents for PAH removal, and addressing a critical need for selective and efficient materials in environmental remediation., (© 2024 Wiley‐VCH GmbH.)

Chiral self-sorting during the formation of cage-like molecules continues to fascinate and advance our understanding of the phenomenon in general. Herein, we report the chiral self-sorting in the Pd 6 L 12 -type metal-organic cages. When a racemic mixture of axially chiral bis-pyridyl ligands undergo coordination-driven self-assembly with Pd(II) ions to form Pd 6 L 12 -type cages, the system has the option of chiral self-sorting to afford any of at least 70 pairs of (one homochiral and 69 heterochiral) enantiomers and 5 meso isomers or a statistical mixture of everything. However, the system resulted in diastereoselective self-assembly through a high-fidelity chiral social self-sorting to form a racemic mixture of D 3 symmetric heterochiral [Pd 6 (L 6R/6S ) 12 ] 12+ /[Pd 6 (L 6S/6R ) 12 ] 12+ cages., (© 2023 Wiley-VCH GmbH.)