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8 results on '"Ghosh, Archit K."'

2. High enhancer activity is an epigenetic feature of HPV negative atypical head and neck squamous cell carcinoma

Author

Callahan, S. Carson, primary, Kochat, Veena, additional, Liu, Zhiyi, additional, Raman, Ayush T., additional, Divenko, Margarita, additional, Schulz, Jonathan, additional, Terranova, Christopher J., additional, Ghosh, Archit K., additional, Tang, Ming, additional, Johnson, Faye M., additional, Wang, Jing, additional, Skinner, Heath D, additional, Pickering, Curtis R., additional, Myers, Jeffrey N., additional, and Rai, Kunal, additional

Published
2022
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4. Reprogramming of bivalent chromatin states in NRAS mutant melanoma suggests PRC2 inhibition as a therapeutic strategy

Author

Terranova, Christopher J., primary, Tang, Ming, additional, Maitituoheti, Mayinuer, additional, Raman, Ayush T., additional, Ghosh, Archit K., additional, Schulz, Jonathan, additional, Amin, Samir B., additional, Orouji, Elias, additional, Tomczak, Katarzyna, additional, Sarkar, Sharmistha, additional, Oba, Junna, additional, Creasy, Caitlin, additional, Wu, Chang-Jiun, additional, Khan, Samia, additional, Lazcano, Rossana, additional, Wani, Khalida, additional, Singh, Anand, additional, Barrodia, Praveen, additional, Zhao, Dongyu, additional, Chen, Kaifu, additional, Haydu, Lauren E., additional, Wang, Wei-Lien, additional, Lazar, Alexander J., additional, Woodman, Scott E., additional, Bernatchez, Chantale, additional, and Rai, Kunal, additional

Published
2021
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5. Chromatin state dynamics confers specific therapeutic strategies in enhancer subtypes of colorectal cancer

Author

Orouji, Elias, primary, Raman, Ayush T, additional, Singh, Anand K, additional, Sorokin, Alexey, additional, Arslan, Emre, additional, Ghosh, Archit K, additional, Schulz, Jonathan, additional, Terranova, Christopher, additional, Jiang, Shan, additional, Tang, Ming, additional, Maitituoheti, Mayinuer, additional, Callahan, Scot C, additional, Barrodia, Praveen, additional, Tomczak, Katarzyna, additional, Jiang, Yingda, additional, Jiang, Zhiqin, additional, Davis, Jennifer S, additional, Ghosh, Sukhen, additional, Lee, Hey Min, additional, Reyes-Uribe, Laura, additional, Chang, Kyle, additional, Liu, Yusha, additional, Chen, Huiqin, additional, Azhdarinia, Ali, additional, Morris, Jeffrey, additional, Vilar, Eduardo, additional, Carmon, Kendra S, additional, Kopetz, Scott E, additional, and Rai, Kunal, additional

Published
2021
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6. Chromatin state dynamics confers specific therapeutic strategies in enhancer subtypes of colorectal cancer.

Author

Orouji, Elias, Raman, Ayush T., Singh, Anand K., Sorokin, Alexey, Arslan, Emre, Ghosh, Archit K., Schulz, Jonathan, Terranova, Christopher, Shan Jiang, Ming Tang, Maitituoheti, Mayinuer, Callahan, Scot C., Barrodia, Praveen, Tomczak, Katarzyna, Yingda Jiang, Zhiqin Jiang, Davis, Jennifer S., Ghosh, Sukhen, Hey Min Lee, and Reyes-Uribe, Laura

Subjects
COLORECTAL cancer, DASATINIB, MEDICAL sciences, COLORECTAL liver metastasis, CHROMATIN, LEUCINE, P53 antioncogene, COLOR blindness, HEREDITARY nonpolyposis colorectal cancer
Published
2022
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7. Chromatin State Dynamics Confers Specific Therapeutic Strategies in Enhancer Subtypes of Colorectal Cancer

Author

Orouji, Elias, primary, Raman, Ayush T., additional, Singh, Anand K., additional, Sorokin, Alexey, additional, Arslan, Emre, additional, Ghosh, Archit K., additional, Schulz, Jonathan, additional, Terranova, Christopher J., additional, Tang, Ming, additional, Maitituoheti, Mayinuer, additional, Callahan, S. Carson, additional, Tomczak, Katarzyna J., additional, Jiang, Zhiqin, additional, Davis, Jennifer S., additional, Ghosh, Sukhen, additional, Lee, Hey Min, additional, Reyes-Uribe, Laura, additional, Chang, Kyle, additional, Liu, Yushua, additional, Chen, Huiqin, additional, Azhdarnia, Ali, additional, Morris, Jeffrey S., additional, Vilar, Eduardo, additional, Carmon, Kendra S., additional, Kopetz, Scott, additional, and Rai, Kunal, additional

Published
2020
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8. Reprogramming of bivalent chromatin states in NRASmutant melanoma suggests PRC2 inhibition as a therapeutic strategy

Author

Terranova, Christopher J., Tang, Ming, Maitituoheti, Mayinuer, Raman, Ayush T., Ghosh, Archit K., Schulz, Jonathan, Amin, Samir B., Orouji, Elias, Tomczak, Katarzyna, Sarkar, Sharmistha, Oba, Junna, Creasy, Caitlin, Wu, Chang-Jiun, Khan, Samia, Lazcano, Rossana, Wani, Khalida, Singh, Anand, Barrodia, Praveen, Zhao, Dongyu, Chen, Kaifu, Haydu, Lauren E., Wang, Wei-Lien, Lazar, Alexander J., Woodman, Scott E., Bernatchez, Chantale, and Rai, Kunal

Abstract

The dynamic evolution of chromatin state patterns during metastasis, their relationship with bona fide genetic drivers, and their therapeutic vulnerabilities are not completely understood. Combinatorial chromatin state profiling of 46 melanoma samples reveals an association of NRASmutants with bivalent histone H3 lysine 27 trimethylation (H3K27me3) and Polycomb repressive complex 2. Reprogramming of bivalent domains during metastasis occurs on master transcription factors of a mesenchymal phenotype, including ZEB1, TWIST1, and CDH1. Resolution of bivalency using pharmacological inhibition of EZH2 decreases invasive capacity of melanoma cells and markedly reduces tumor burden in vivo, specifically in NRASmutants. Coincident with bivalent reprogramming, the increased expression of pro-metastatic and melanocyte-specific cell-identity genes is associated with exceptionally wide H3K4me3 domains, suggesting a role for this epigenetic element. Overall, we demonstrate that reprogramming of bivalent and broad domains represents key epigenetic alterations in metastatic melanoma and that EZH2 plus MEK inhibition may provide a promising therapeutic strategy for NRASmutant melanoma patients.

Published
2021
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