870 results on '"Giacca M"'
Search Results
2. Mesorectal failure after chemoradiotherapy for squamous cell carcinoma of the anus: is sphincter-saving surgery reasonable?
- Author
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Bertrand, T., Aramburu, J. F., Labiad, C., Giacca, M., Monsinjon, M., and Panis, Y.
- Published
- 2023
- Full Text
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3. Dissecting signal transduction pathways that regulate cardiomyocyte proliferation
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Artioli, R, primary, Cannilla, R, additional, Dal Ferro, M, additional, Zentilin, L, additional, Giacca, M, additional, and Collesi, C, additional
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- 2024
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4. Exploring the interactions between cardiomyocytes and endothelial cells to induce cardiac revascularization and regeneration
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Vuerich, R, primary, Colliva, A, additional, Vodret, S, additional, Volpe, M C, additional, Braga, L, additional, Canarutto, G, additional, Piazza, S, additional, Pedrazzini, T, additional, Chiesa, M, additional, Cauteruccio, M, additional, Ramadan, M, additional, Zentilin, L, additional, Giacca, M, additional, and Zacchigna, S, additional
- Published
- 2024
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5. Mechanical load regulates the proliferation of multiple cell types in the heart
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Ciucci, G, primary, Colliva, A, additional, Vodret, S, additional, Texler, B, additional, Cardini, B, additional, Oberhuber, R, additional, Vuerich, R, additional, Zago, E, additional, Maglione, M, additional, Sinagra, G, additional, Giacca, M, additional, Eschenhagen, T, additional, Golino, P, additional, Loffredo, F, additional, and Zacchigna, S, additional
- Published
- 2024
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6. C-reactive protein monitoring after ileocecal resection and stoma closure reduces length of hospital stay: a prospective case-matched study in 410 patients with Crohn’s disease
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Guyard, C., de Ponthaud, C., Frontali, A., Monsinjon, M., Giacca, M., and Panis, Y.
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- 2022
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7. Role of long non-coding RNA Zeb2os in protection of the injured heart
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Caliandro, R, primary, Boender, A, additional, Van Rooij, E, additional, Boink, G J J, additional, Giacca, M, additional, Christoffels, V M, additional, and Gladka, M M, additional
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- 2023
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8. Global deficiency in the inflammatory chemokine receptors 1,2,3 and 5 ameliorates atherosclerosis and selectively modulates aortic myeloid cell phenotype
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Macritchie, N, primary, Shoaran, M, additional, Gurgone, D, additional, Gu, S, additional, Mcshane, L, additional, Bin Khunayn, A M A, additional, Caiazzo, E, additional, Giacca, M, additional, Zentilin, L, additional, Monaco, C, additional, Pasterkamp, G, additional, Olofsson, P S, additional, Guzik, T J, additional, Graham, G J, additional, and Maffia, P, additional
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- 2023
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9. Will our cardiomyopathy patients accept gene therapy?
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Doevendans, P. A., Kupatt, C., Giacca, M., and Glijnis, P.
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- 2022
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10. Living myocardial slices for the study of nucleic acid-based therapies
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Nunez-Toldra, R., primary, Del Canizo, A., additional, Secco, I., additional, Nicastro, L., additional, Giacca, M., additional, and Terracciano, C. M., additional
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- 2023
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11. A Understanding the role of cardiac fibrosis in the development and treatment of heart failure using molecular imaging probes and novel therapeutics
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Amoiradaki, K, primary, Tomczyk, M, additional, Lima da Cruz, G, additional, Velasco, C, additional, Bortolotti, F, additional, Prieto, C, additional, Botnar, R, additional, Giacca, M, additional, and Phinikaridou, A, additional
- Published
- 2023
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12. Intravenous lipid infusion and total plasma fatty acids positively modulate plasma acylated ghrelin in vivo
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Barazzoni, R., Gortan Cappellari, G., Semolic, A., Ius, M., Dore, F., Giacca, M., Zanetti, M., Vinci, P., and Guarnieri, G.
- Published
- 2017
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13. Effectiveness of Intraoperative Parathyroid Monitoring (ioPTH) in predicting a multiglandular or malignant parathyroid disease
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Dobrinja, C., Santandrea, G., Giacca, M., Stenner, Elisabetta, Ruscio, Maurizio, and de Manzini, Nicolò
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- 2017
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14. N-3 Pufa Enriched Diet Preserves Skeletal Muscle Mitochondrial Function, Redox State And Insulin Signalling In Mice With Chronic Heart Failure
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Gortan Cappellari, G., primary, Aleksova, A., additional, Dal Ferro, M., additional, Cannatà, A., additional, Semolic, A., additional, Zanetti, M., additional, Giacca, M., additional, Sinagra, G., additional, and Barazzoni, R., additional
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- 2023
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15. SARS-CoV-2 Spike protein activates TMEM16F-mediated platelet procoagulant activity
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Cappelletto, A, Allan, HE, Crescente, M, Schneider, E, Bussani, R, Ali, H, Secco, I, Vodret, S, Simeone, R, Mascaretti, L, Zacchigna, S, Warner, TD, Giacca, M, Cappelletto, A, Allan, HE, Crescente, M, Schneider, E, Bussani, R, Ali, H, Secco, I, Vodret, S, Simeone, R, Mascaretti, L, Zacchigna, S, Warner, TD, and Giacca, M
- Abstract
Thrombosis of the lung microvasculature is a characteristic of COVID-19 disease, which is observed in large excess compared to other forms of acute respiratory distress syndrome and thus suggests a trigger for thrombosis that is endogenous to the lung. Our recent work has shown that the SARS-CoV-2 Spike protein activates the cellular TMEM16F chloride channel and scramblase. Through a screening on >3,000 FDA/EMA approved drugs, we identified Niclosamide and Clofazimine as the most effective molecules at inhibiting Spike-induced TMEM16 activation. As TMEM16F plays an important role in stimulating the procoagulant activity of platelets, we investigated whether Spike directly affects platelet activation and pro-thrombotic function and tested the effect of Niclosamide and Clofazimine on these processes. Here we show that Spike, present either on the virion envelope or on the cell plasma membrane, promotes platelet activation, adhesion and spreading. Spike was active as a sole agonist or, even more effectively, by enhancing the function of known platelet activators. In particular, Spike-induced a marked procoagulant phenotype in platelets, by enhancing Ca2+ flux, phosphatidylserine externalization on the platelet outer cell membrane, and thrombin generation. Eventually, this increased thrombin-induced clot formation and retraction. Both Niclosamide and Clofazimine blocked this Spike-induced procoagulant response. These findings provide a pathogenic mechanism to explain lung thrombosis-associated with severe COVID-19 infection. We propose that Spike, present in SARS-CoV-2 virions or exposed on the surface of infected cells in the lungs, enhances the effects of inflammation and leads to local platelet stimulation and subsequent activation of the coagulation cascade. As platelet TMEM16F is central in this process, these findings reinforce the rationale of repurposing Niclosamide for COVID-19 therapy.
- Published
- 2023
16. Plasma total and unacylated ghrelin predict 5-year changes in insulin resistance
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Barazzoni, R., Gortan Cappellari, G., Semolic, A., Ius, M., Mamolo, L., Dore, F., Giacca, M., Zanetti, M., Vinci, P., and Guarnieri, G.
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- 2016
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17. VEGF121 and VEGF165 differentially promote vessel maturation and tumor growth in mice and humans
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Kazemi, M, Carrer, A, Moimas, S, Zandonà, L, Bussani, R, Casagranda, B, Palmisano, S, Prelazzi, P, Giacca, M, Zentilin, L, De Manzini, N, Giacca, M, and Zacchigna, S
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- 2016
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18. What is the best surgical option after failure of graciloplasty in patients with recurrent rectovaginal fistula? A study of 19 consecutive patients
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Muller, O., primary, Labiad, C., additional, Frontali, A., additional, Giacca, M., additional, Monsinjon, M., additional, and Panis, Y., additional
- Published
- 2022
- Full Text
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19. Repeated AAV-mediated gene transfer by serotype switching enables long-lasting therapeutic levels of hUgt1a1 enzyme in a mouse model of Crigler–Najjar Syndrome Type I
- Author
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Bočkor, L, Bortolussi, G, Iaconcig, A, Chiaruttini, G, Tiribelli, C, Giacca, M, Benvenuti, F, Zentilin, L, and Muro, A F
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- 2017
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20. AAV9-mediated engineering of autotransplanted kidney of non-human primates
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Tomasoni, S, Trionfini, P, Azzollini, N, Zentilin, L, Giacca, M, Aiello, S, Longaretti, L, Cozzi, E, Baldan, N, Remuzzi, G, and Benigni, A
- Published
- 2017
- Full Text
- View/download PDF
21. Nucleic acid-based therapies using living myocardial slices
- Author
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Nunez-Toldra, R, primary, Del Canizo, A, additional, Secco, I, additional, Nicastro, L, additional, Giacca, M, additional, and Terracciano, C M, additional
- Published
- 2022
- Full Text
- View/download PDF
22. Mesorectal failure after chemoradiotherapy for squamous cell carcinoma of the anus: is sphincter-saving surgery reasonable?
- Author
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Bertrand, T., primary, Aramburu, J. F., additional, Labiad, C., additional, Giacca, M., additional, Monsinjon, M., additional, and Panis, Y., additional
- Published
- 2022
- Full Text
- View/download PDF
23. The furin cleavage site of SARS-CoV-2 spike protein is a key determinant for transmission due to enhanced replication in airway cells
- Author
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Peacock, T, Goldhill, D, Zhou, J, Baillon, L, Frise, R, Swann, O, Kugathasan, R, Penn, R, Brown, J, Sanchez-David, R, Braga, L, Williamson, MK, Hassard, J, Staller, E, Hanley, B, Osborn, M, Giacca, M, Davidson, A, Matthews, D, and Barclay, W
- Abstract
SARS-CoV-2 enters cells via its spike glycoprotein which must be cleaved sequentially at the S1/S2, then the S2’ cleavage sites (CS) to mediate membrane fusion. SARS-CoV-2 has a unique polybasic insertion at the S1/S2 CS, which we demonstrate can be cleaved by furin. Using lentiviral pseudotypes and a cell-culture adapted SARS-CoV-2 virus with a S1/S2 deletion, we show that the polybasic insertion is selected for in lung cells and primary human airway epithelial cultures but selected against in Vero E6, a cell line used for passaging SARS-CoV-2. We find this selective advantage depends on expression of the cell surface protease, TMPRSS2, that allows virus entry independent of endosomes thus avoiding antiviral IFITM proteins. SARS-CoV-2 virus lacking the S1/S2 furin CS was shed to lower titres from infected ferrets and was not transmitted to cohoused sentinel animals. Thus, the polybasic CS is a key determinant for efficient SARS-CoV-2 transmission.
- Published
- 2022
24. Local delivery of the Neuregulin1 receptor ecto-domain (ecto-ErbB4) has a positive effect on regenerated nerve fiber maturation
- Author
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Gambarotta, G, Pascal, D, Ronchi, G, Morano, M, Jager, S B, Moimas, S, Zentilin, L, Giacca, M, Perroteau, I, Tos, P, Geuna, S, and Raimondo, S
- Published
- 2015
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25. Will our cardiomyopathy patients accept gene therapy?
- Author
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Cardiologie, Team Medisch, Circulatory Health, Regenerative Medicine and Stem Cells, Doevendans, P. A., Kupatt, C., Giacca, M., Glijnis, P., Cardiologie, Team Medisch, Circulatory Health, Regenerative Medicine and Stem Cells, Doevendans, P. A., Kupatt, C., Giacca, M., and Glijnis, P.
- Published
- 2022
26. Laparoscopic ileocolic iterative resection with fluorescence‐guided lymphatic mapping – a video vignette
- Author
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Silvestri, M., Guerra, M., Giacca, M., Casagranda, B., Palmisano, S., and de Manzini, N.
- Published
- 2017
- Full Text
- View/download PDF
27. Body mass index and complications following major gastrointestinal surgery
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Blanco-Colino R, Lee S, Kamarajah SK, Vasko P, Kuiper SZ, Farina V, Chapman SJ, Drake TM, Gavagna L, Pasquali S, Pata F, Pellino G, de la Rosa-Estadella M, Stellingwerf ME, Stijns RCH, Borrellas A, Golding D, Ngaage M, Van Tol RR, de Groof J, de Wilt H, Bemelman WA, McNamee L, Espin-Basany E, Emre Baki B, Gecim IE, Can Tatar O, Bach S, Bhangu A, Bresges K, Burke J, Claireaux HA, Fearnhead N, Fitzgerald JE, Gallagher S, Glasbey JC, Gundogan B, Harrison EM, Hernon J, Khatri C, Kong CY, Lyons A, Mohan M, Morton D, Pinkney TD, Arezzo A, Foppa C, Morino M, Rubbini M, Selvaggi F, Sensi B, Sica G, Orhalmi J, Naccari P, Sgrò A, Burger BHCM, Fares DA, Spijkerman R, van Elst TR, Wiersema R, Stassen LPS, Rodriguez Garcia R, Özkan BB, Tavuz AI, Demirci ZS, Baki BE, Choi PJ, O'Sullivan H, Salman M, Simioni A, Colombo F, Turati L, Cazzola FE, Gallo G, Perrotta G, Papandrea M, Naccari PM, Menduni N, Rossi E, Chetta N, Romeo F, Giordano F, Randisi B, Curletti G, Kuiper J, Costa A, Marcos Rodrigo A, Sanchez A, Varo Muñoz A, Martinez Rios CE, Aliseda-Jover D, Fernandez Nieto D, Alvarez Reyes I, Dominguez Rodriguez LM, Hernandez Ros MI, Esteban Sinovas O, Bartrina Soler P, Villarejo Campos P, Laguna Román S, Fontanet-Soler S, Raurich-Leandro J, Dominguez-Prieto V, Segura-Sampedro JJ, Alconchel-Gago F, Salazar-García C, Gezen AE, Sahin A, Atasoy H, Yuksek B, Arslan E, Ozmen BB, Sen AY, Erol HI, Ucar E, Aktas MK, Yurdaor SS, Mermer S, Seyhan U, Tosun V, Gunaydin Y, Ekinci ZB, Yazkan Z, Choi J, Yeoh TSL, Jones CS, Venturini S, Saat MI, Loo J, Pike G, Davies SC, Kabariti R, Olivier J, Hurný M, Žebrák R, Machačová A, Schulzová M, Smolák P, Široká M, Palyzová H, Jaroš J, Dušek T, Šimáčková B, Bartoš M, Sotona O, Pös M, Karásek D, Higgins P, Hacking S, Arora E, Coughlan G, Palanivail N, Quill S, Zhang AA, Malak M, Maan DS, Cheema J, Goh AWJ, Shamsul Badrin AK, Guinness F, Howard James N, Neary A, Sebaoui S, Gilroy D, Petrov G, Craven K, MacDonald A, Redmond A, Brennan D, Roche D, O'Dwyer M, Collins P, Edwards S, Doyle J, Tiedt L, Arthurs B, O'Byrne L, Kiely A, Glynn M, Sproule L, Heaney A, Li Hi Shing S, Goh W, Al-Nasser Z, Al-Nasser A, Teh JW, De Boni D, Goldin E, Ciccioli E, Vendramin E, Marchese N, Bruno M, Vinci A, Harder G, Morandi V, Magnoli M, Suppa A, Palmieri A, Martorana M, Sette M, Balagna P, Cruciani C, Corte M, Ciano P, Bagaglini G, Montuori M, Di Benedetto L, Arcudi C, Pezzuto R, Saraceno F, Milana F, Franceschilli M, Rizzi A, Sampietro G, Rampulla V, Bianco F, Boschetti ME, Ghignone F, Bianchini S, Esposto R, Riva L, Riva M, Cannavò M, Arrigo A, Giavarini L, Colombo EM, Trompetto M, Clerico G, Catalano M, Dosa T, El Mabruk M, Barone V, Pallara E, Pasqualoni M, Caudullo G, Mastandrea Bonaviri GN, Muro M, Pistola I, Verardi L, Ferrara D, Gerardi S, Remore LM, Belia F, Del Coco F, Larotonda C, Botrugno EM, Cammarota A, Di Girolami L, Laterza V, Laurino A, Paolo G, Santocchi P, Puccioni C, Truma A, Giardino FR, Giuffrida A, Ripa M, Cautiero R, Patturelli M, Capozzolo A, Selvaggi L, Facchiano A, Milazzo LF, Papazachariou SK, Pattapola V, Anania G, Feo C, Bellinato M, Priani P, Zigiotto D, Troia A, Vable T, Piran G, Targa S, Pulpito S, Tagariello F, Fasano A, Anconelli D, Castiglione F, Tognolo L, Lopez G, Campion A, Tarantino M, Sacco R, Sammarco G, Palmisano S, Giacca M, Rocco I, Bellio G, Favero A, Raimondi P, Pantalone MR, De Nardi P, Notarnicola M, Picciariello A, Licari L, Parinisi Z, Fazzotta S, Ciciliot M, Reggiani L, Mariani F, Aonzo P, Checcacci P, Montanelli P, Guerra F, Skalamera I, Staderini F, Grandi S, Nelli T, de Boer DV, van der Pool AEM, Janssen TL, El-Atmani S, van Verschuer VMT, Poelman M, Dronkers WJ, van Steensel L, Toorenvliet BR, Duinhouwer LE, Vermaas M, Ter Bruggen FFJA, Hogendoorn W, van der Harst E, van Rijckevorsel VAJIM, Bayoumy AB, Lap CR, Gooszen JAH, Abdulrahman N, de Roy van Zuidewijn D, de Groof EJ, Zijlmans JL, van Dalen ASHM, Bos K, Musters GD, Looijen RC, Fliers JM, Oostendorp SE, Mosterd CM, Blonk L, Jurgens J, Ribbink ME, Boom MS, Boersma AM, Hidding E, Schmidt PA, Mensink G, Graus SA, Gastel MDA, Veenker CGH, Van Heumen TM, Slieker FJB, Sedee WJA, Löwensteyn YN, Amelung FJ, de Guerre LEVM, Nota CLMA, Van Dijck WPM, van Wijnbergen JWM, Pronk A, Kip M, van der Zee C, Heiloo S, Muller S, Verboeket B, Oudman TS, Zope S, Gilissen V, Gommers J, Cremers D, Van der Lubbe M, Smet M, Ter Weele K, de Bruin M, Geerlings M, Ter Horst L, Kerimova N, Pesser N, Heesakkers H, de Mees T, de Gooyer JM, Willems L, Gawria L, Bonouvrie D, Harms J, Eggen Y, Hengeveld E, Smeets HJ, Hoffman RPC, Detmers Blom FPN, Van Bruggen D, Steup WH, Gooiker GA, Willems YR, van der Hoeven AC, Vallve-Bernal M, Perez-Gandara B, Perez JL, Caballero Rodriguez E, Perez Febles M, Protti Ruiz GP, Hidalgo Pujol M, Alberti Delgado P, Gil Barrionuevo E, Anabitarte O, Caballero L, Poyato Nuñez FJ, Prado Perez R, de la Portilla de Juan F, Fulgencio Barbarin J, Elorza Echaniz G, Mitxelena Elosegi L, Delgado AT, Marti Gelonch L, Gonzalez Arribas M, De Serra Tejada I, Alberdi San Roman I, de Andres Olabarria U, Fernández-Domper L, Perez Costoya C, Perez Arias H, Fa Binefa M, Becerra Nieves M, Escalona Canal MG, Aldrey I, Vazquez-Gonzalez I, Falcon Cazas A, Amarelo Garcia M, Gonzalez Ruiz AA, Garcia Garrido M, Simon Frapolli V, Martinez Diaz JM, De la Torre Conde C, Rodrigues Silva K, Hernandez Kakauridze S, Lopez Garcia MC, Flores Funes D, Gómez-López de San Román C, San Martín Bragado M, Tejero Pintor FJ, Pando Ruiz B, Sánchez Estébanez E, Roquet Puigneró E, Pla Seró S, Vela Polanco FF, Mirallas Viñas O, Caro Gonzalez MP, Bertelli Puche JL, Gonzalez-Martinez A, Sanchez Cambronero M, Garcia Torres A, Dominguez Jimenez M, de Jesus Rodriguez Perdomo M, Echazarreta-Gallego E, Sánchez-Blasco L, Del Mar López-Cuevas M, Latras-Cortés I, López-Vendrell L, Díaz Padillo A, Mestres Petit N, Cruz Reyes JA, Fernandez C, Posada M, Moratilla Lapeña L, Martin Morales E, Mate-Mate P, Garcia Cruz G, Gorini L, Rubio-Perez I, Soldevila-Verdeguer C, Jiménez-Viñas C, Luehrman A, Sena-Ruiz F, Garcia-Perez JM, Plomer-Sanchez M, Pujol-Cano N, Jimenez-Segovia M, Diaz-Jover P, Pineño-Flores C, Ambrona-Zafra D, Gonzalez-Argente XF, Jiménez-Morillas P, López-Mármol R, Durán-Martínez M, González-Crespo A, Checa Guillen M, Valderrama Pérez A, Claramonte Bellmunt O, Martí Fernández RM, Kasap S, Soylemez ZOBB, Bolat AB, Aydar SEYI, Birgin BZ, Coskun O, Cakir SG, Belibagli ZO, Herken M, Erdem S, Kayacan S, Kelesoglu Y, Moran D, Atalay H, Kucukdiler E, Demirci A, Buyukkasap C, Kuzey A, Emral C, Dogan H, Cok H, Durmaz H, Asma A, Ergul B, Kaya A, Bilicen G, Gunay M, Senturk E, Baskoy L, Besısık HM, Topalan K, Piraliyev E, Danalıoglu AN, Ilbak A, Yıgman S, Kara C, Guzel M, Inci ET, Onsal U, Erel T, Cetin SK, Yekenkurul E, Kasar P, Saglam ZA, Gursoy F, Cetinkaya M, Aktekin H, Bober DN, Mugurtay YS, Koksal G, Celik S, Bektur G, Yildirim R, Ankarali T, Güven H, Yuksel A, Semiz A, Cise S, Tomas K, Ulusahin M, Akbulut F, Tulum H, Bodur S, Isler VC, Pektas AM, Mutlu D, Mericliler M, Tansoker I, Polat ZP, Seyrek N, Beyatli S, Toto OF, Cakaloglu HC, Sapci I, Akpunarli B, Adiyaman C, Kobal BB, Gok Z, Benli S, Turpan M, Kocapinar S, Parimli H, Acar S, Eger M, Yilmaz I, Cengiz U, Yoruk I, Mutlu B, Ulkucu A, Arukan C, Kara B, Gokce K, Calisgan B, Demirci K, Elkatroushi T, Ayaz B, Uzun B, Sivrikaya T, Goksoy B, Eroz E, Celik B, Canbay Torun B, Ekin B, Senay BB, Temiz C, Yilmaz M, Yasar C, Cakir E, Subasi A, Celik K, Aksoy K, Karabulut E, Altintas O, Bali AN, Ciftci E, Babaoglu H, Aljbour A, Aljbour I, Akcaoglu T, Kakil E, Taskin O, Taskin RB, Topal U, Huzmeli E, Caliskan T, Unal AG, Yurekli AM, Sari V, Tutam DN, Celen D, Posteki G, Demirtas B, Yildiz S, Kilic E, Yalcin Y, Kurt A, Gozubuyuk Y, Huseynova S, Cinar S, Calar SN, Kurklu O, Binbuga M, Ceylan C, Yavuz G, Alim YE, Yildirim N, Yilmaz S, Onar D, Aray E, Ozsipahi AC, Koc GE, Yetiskin E, Kocer MD, Ozgencil B, Bahcecioglu B, Hacioglu AD, Bilici O, Cin S, Uzunoglu EC, Cumen EC, Aslan L, Erozgur B, Yildiz SS, Zengin T, Kullac S, Mizan SR, Baykan B, Kopac O, Karabacak U, Aytekin A, Deliktas TS, Buyukkarabacak Y, Uzun O, Karahan B, Turkmen M, Akdogan A, Uctepe F, Bandirmali O, Erdogan P, Demir F, Bozkurt GK, Yilmaz T, Sheikh IMI, Orhan K, Balci B, Keyif MF, Bilgin S, Cantimer E, Yaman S, Akkaya E, Atesavci SN, Arslan U, Asik M, Koksal S, Murtaza MI, Mustafa S, Oun H, Sam ZH, Brogan A, Zaidi R, Quinn K, Taylor F, Pang G, Heath H, Smart NJ, Home J, Mauro D, Noone TM, Fenn J, Sinha A, Lowe R, Hutchings I, Longstaff L, Smith AG, Edwards JA, Alcocer BP, Oakley T, Thomas-Davies M, Hourston GJM, Kankam HKN, Ramana A, Baker C, Endo Y, Wong C, Anderson RGJ, Badran A, Ali A, Myers L, Tippins F, Stanley S, Sandison L, Schofield E, Delf J, Rees S, Anyan-Brown J, Long K, Archer M, Anakwenze V, Goel S, Sharma Khatiwada A, Khan S, Leafe O, Lee J, Embury-Young Y, Edwards L, Hazenberg P, Agrawal M, Guerero D, Britton F, Rejayee M, Mahesh S, Khaing PH, Baldwin A, Iyer S, Gaskell P, Adlan A, Cuckow L, Barmayehvar B, Rob T, Ciurleo C, Mural-Krishnan S, Jong N, Carlson S, Abdelgalil R, Goble M, Doshi A, Ogunleye O, Marsh L, Bagley J, Poacher A, Cantelo J, Wylie J, Govil S, Hill F, Beaver D, Urquhart A, Rakhimov I, Raina V, Clifford T, Iorga R, Cartwright E, Harris AJ, Shurovi B, Wadanamby S, Brown E, Bradley C, Ahmad A, Jeyabraba S, Hardaman B, Truss A, Mohamed US, Örhalmi J, Kerin MJ, Reynolds J, Ridgway P, Pietrabissa A, Foschi D, Sgroi G, Rosati G, Benevento A, Coco C, Persiani R, Vasquez G, Messina F, De Manzini N, Innocenti P, Rosati R, Altomare DF, Sartori A, Salamone G, Galleano R, Cianchi F, Wijnhoven BPL, van de Ven AWH, de Vos Tot Nederveen Cappel RJ, de Castro SMM, Meijerink WJHJ, Mulder IM, Acherman YIZ, van Leeuwen BL, Schasfoort RA, Kloppenberg FWH, Wiezer R, Consten ECJ, Van Grevenstein WMU, Schiphorst A, Wijffels N, Uittenbogaart M, Klinkert M, Koppe M, de Hingh I, Konsten J, Polat F, Berends F, Langenhoff B, Zimmerman D, van 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A, Tharakan RG, Parsons S, Buchan AM, McGalliard RJ, Mason JD, Cundy OJ, Li N, Redgrave NA, Watson RP, Pezas TP, Dennis YF, Segall E, Hameed M, Lynch AS, Chamberlain M, Peck FS, Neo YN, Russell G, Elseedawy M, Foster NL, Soo YH, Puan L, Dennis R, Goradia H, Qureshi A, Osman S, Reeves T, Dinsmore L, Marsden M, Lu Q, Pitts-Tucker T, Dunn CE, Walford RA, Heathcote E, Martin R, Pericleous A, Brzyska K, Reid KG, Williams MR, Wetherall N, McAleer E, Thomas D, Kiff R, Milne S, Holmes MJV, Bartlett J, Lucas de Carvalho J, Bloomfield T, Tongo F, Bremner RH, Yong N, Atraszkiewicz BA, Mehdi A, Tahir M, Sherliker GXJ, Tear AK, Pandey A, Broyd A, Omer HM, Raphael M, Chaudhry WW, Shahidi S, Jawad AS, Gill CK, Hindle Fisher I, Adeleja I, Clark IJ, Aidoo-Micah GE, Stather PW, Salam GJ, Glover TE, Deas G, Sim NK, Obute RD, Wynell-Mayow WM, Sait MS, Mitha N, de Bernier GL, Siddiqui M, Shaunak R, Wali A, Cuthbert G, Bhudia R, Webb E, Shah S, Ansari N, Perera M, Kelly N, McAllister R, Stanley GH, Keane 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Nachiappan R, Egan RJ, Owasil R, Kwan ML, He A, Goh RW, Bhome R, Wilson H, Teoh PJ, Raji K, Jayakody N, Matthams J, Chong J, Luk CY, Greig RJ, Trail M, Charalambous G, Rocke AS, Gardiner N, Bulley F, Warren N, Brennan E, Fergurson P, Wilson R, Whittingham H, Brown EJ, Khanijau R, Gandhi K, Morris S, Boulton AJ, Chandan N, Barthorpe AE, Maamari R, Sandhu S, McCann M, Higgs L, Balian V, Reeder C, Diaper C, Sale T, Ali H, Archer CH, Clarke AK, Heskin J, Hurst PC, Farmer JD, O'Flynn LD, Doan L, Shuker BA, Stott GD, Vithanage NA, Hoban KA, Nesargikar PN, Kennedy HR, Grossart CM, Tan ESM, Roy CSD, Sim P, Leslie KE, Sim D, Abul MH, Cody N, Tay AY, Woon E, Sng S, Mah J, Robson J, Shakweh E, Wing VC, Mills H, Li MM, Barrow TR, Balaji S, Jordan HEM, Phillips C, Naveed H, Hirani S, Tai A, Ratnakumaran R, Sahathevan A, Shafi AMA, Seedat M, Weaver R, Batho A, Punj R, Selvachandran H, Bhatt N, Botchey S, Khonat Z, Brennan K, Morrison CJ, Devlin E, Linton A, Galloway E, McGarvie S, Ramsay N, McRobbie HD, Whewell H, Dean W, Nelaj S, Eragat M, Mishra A, Kane T, Zuhair M, Wells M, Wilkinson D, Woodcock N, Sun E, Aziz N, Abd Ghaffar MK., Nepogodiev, Dmitri, Rosati, Riccardo, Nepogodiev, D., and Robotics and image-guided minimally-invasive surgery (ROBOTICS)
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Male ,obesity ,Multivariate analysis ,Gastrointestinal Diseases ,IMPACT ,Settore MED/18 - CHIRURGIA GENERALE ,Body mass index ,Body weight ,Digestive tract ,Gastrointestinal tract ,Obesity ,Postoperative complications ,Gastroenterology ,digestive tract ,Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14] ,0302 clinical medicine ,Risk Factors ,Medicine ,Prospective Studies ,Prospective cohort study ,Aged ,Europe ,Female ,Gastrointestinal Neoplasms ,Humans ,Middle Aged ,Postoperative Complications ,Body Mass Index ,OUTCOMES ,body mass index ,body weight ,gastrointestinal tract ,030220 oncology & carcinogenesis ,Meta-analysis ,Urological cancers Radboud Institute for Health Sciences [Radboudumc 15] ,Cohort ,030211 gastroenterology & hepatology ,Cohort study ,medicine.medical_specialty ,Malignancy ,NO ,03 medical and health sciences ,SDG 3 - Good Health and Well-being ,business.industry ,postoperative complications ,MORTALITY ,medicine.disease ,Settore MED/18 ,Surgery ,Postoperative complication ,Postoperative Complications, Obesity, Digestive Tract, Gastrointestinal Tract, Body Mass Index, Body Weight ,business - Abstract
Aim Previous studies reported conflicting evidence on the effects of obesity on outcomes after gastrointestinal surgery. The aims of this study were to explore the relationship of obesity with major postoperative complications in an international cohort and to present a meta-analysis of all available prospective data.Methods This prospective, multicentre study included adults undergoing both elective and emergency gastrointestinal resection, reversal of stoma or formation of stoma. The primary end-point was 30-day major complications (Clavien-Dindo Grades III-V). A systematic search was undertaken for studies assessing the relationship between obesity and major complications after gastrointestinal surgery. Individual patient meta-analysis was used to analyse pooled results.Results This study included 2519 patients across 127 centres, of whom 560 (22.2%) were obese. Unadjusted major complication rates were lower in obese vs normal weight patients (13.0% vs 16.2%, respectively), but this did not reach statistical significance (P = 0.863) on multivariate analysis for patients having surgery for either malignant or benign conditions. Individual patient meta-analysis demonstrated that obese patients undergoing surgery for malignancy were at increased risk of major complications (OR 2.10, 95% CI 1.49-2.96, P Conclusions In our international data, obesity was not found to be associated with major complications following gastrointestinal surgery. Meta-analysis of available prospective data made a novel finding of obesity being associated with different outcomes depending on whether patients were undergoing surgery for benign or malignant disease.
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- 2018
28. Dilated Cardiomyopathy: Does Etiological Heterogeneity Portend Clinical Heterogeneity?
- Author
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Mestroni, L., Rocco, C., Miocic, S., Di Lenarda, A., Sinagra, G., Gregori, D., Vatta, M., Matulic, M., Zerjal, T., Falaschi, A., Camerini, F., Giacca, M., Camerini, Fulvio, editor, Gavazzi, Antonello, editor, and De Maria, Renata, editor
- Published
- 1998
- Full Text
- View/download PDF
29. N-3 pufa dietary enrichment modulates mitochondrial dynamics, increases mitophagy and reverses uremia-induced mitochondrial dysfunction in rat skeletal muscle
- Author
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Cappellari, G. Gortan, primary, Semolic, A.M., additional, Ruozi, G., additional, Barbetta, D., additional, Kharrat, F., additional, Zanetti, M., additional, Giacca, M., additional, and Barazzoni, R., additional
- Published
- 2021
- Full Text
- View/download PDF
30. Evaluation of nutritional status in head and neck radio-treated patients affected by oral mucositis: efficacy of class IV laser therapy
- Author
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Gobbo, M., Ottaviani, G., Perinetti, G., Ciriello, F., Beorchia, A., Giacca, M., Di Lenarda, R., Rupel, K., Tirelli, G., Zacchigna, S., and Biasotto, M.
- Published
- 2014
- Full Text
- View/download PDF
31. La chirurgie ne règle pas tout ! Facteurs de risque de récidive de diverticulite sigmoïdienne après chirurgie
- Author
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Aubert, M., primary, Mege, D., additional, Monsinjon, M., additional, Giacca, M., additional, and Panis, Y., additional
- Published
- 2021
- Full Text
- View/download PDF
32. Cluster Analysis of Antibiotic Susceptibility Patterns of Clinical Isolates as a Tool in Nosocomial Infection Surveillance
- Author
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Giacca, M., Menzo, S., Trojan, S., and Monti-Bragadin, C.
- Published
- 1987
33. CARMN Loss Regulates Smooth Muscle Cells and Accelerates Atherosclerosis in Mice
- Author
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Vacante, F, Rodor, J, Lalwani, MK, Mahmoud, AD, Bennett, M, De Pace, AL, Miller, E, Van Kuijk, K, de Bruijn, J, Gijbels, M, Williams, TC, Clark, MB, Scanlon, JP, Doran, AC, Montgomery, R, Newby, DE, Giacca, M, O'Carroll, D, Hadoke, PWF, Denby, L, Sluimer, JC, Baker, AH, Vacante, F, Rodor, J, Lalwani, MK, Mahmoud, AD, Bennett, M, De Pace, AL, Miller, E, Van Kuijk, K, de Bruijn, J, Gijbels, M, Williams, TC, Clark, MB, Scanlon, JP, Doran, AC, Montgomery, R, Newby, DE, Giacca, M, O'Carroll, D, Hadoke, PWF, Denby, L, Sluimer, JC, and Baker, AH
- Abstract
[Figure: see text].
- Published
- 2021
34. Towards standardization of echocardiography for the evaluation of left ventricular function in adult rodents: a position paper of the ESC Working Group on Myocardial Function
- Author
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Zacchigna, S, Paldino, A, Falcao-Pires, I, Daskalopoulos, EP, Dal Ferro, M, Vodret, S, Lesizza, P, Cannata, A, Miranda-Silva, D, Lourenco, A P, Pinamonti, B, Sinagra, G, Weinberger, F, Eschenhagen, T, Carrier, L, Kehat, I, Tocchetti, CG, Russo, M, Ghigo, A, Cimino, J, Hirsch, E, Dawson, D, Ciccarelli, M, Oliveti, M, Linke, WA, Cuijpers, I, Heymans, S, Hamdani, N, Boer, Monique, Duncker, Dirk-jan, Kuster, D, Velden, J, Beauloye, C, Bertrand, L, Mayr, M, Giacca, M, Leuschner, F, Backs, J, Thum, T, Zacchigna, S, Paldino, A, Falcao-Pires, I, Daskalopoulos, EP, Dal Ferro, M, Vodret, S, Lesizza, P, Cannata, A, Miranda-Silva, D, Lourenco, A P, Pinamonti, B, Sinagra, G, Weinberger, F, Eschenhagen, T, Carrier, L, Kehat, I, Tocchetti, CG, Russo, M, Ghigo, A, Cimino, J, Hirsch, E, Dawson, D, Ciccarelli, M, Oliveti, M, Linke, WA, Cuijpers, I, Heymans, S, Hamdani, N, Boer, Monique, Duncker, Dirk-jan, Kuster, D, Velden, J, Beauloye, C, Bertrand, L, Mayr, M, Giacca, M, Leuschner, F, Backs, J, and Thum, T
- Abstract
Echocardiography is a reliable and reproducible method to assess non-invasively cardiac function in clinical and experimental research. Significant progress in the development of echocardiographic equipment and transducers has led to the successful translation of this methodology from humans to rodents, allowing for the scoring of disease severity and progression, testing of new drugs, and monitoring cardiac function in genetically modified or pharmacologically treated animals. However, as yet, there is no standardization in the procedure to acquire echocardiographic measurements in small animals. This position paper focuses on the appropriate acquisition and analysis of echocardiographic parameters in adult mice and rats, and provides reference values, representative images, and videos for the accurate and reproducible quantification of left ventricular function in healthy and pathological conditions.
- Published
- 2021
35. SREBP2 gene therapy targeting striatal astrocytes ameliorates Huntington's disease phenotypes
- Author
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Birolini, G, Verlengia, G, Talpo, F, Maniezzi, C, Zentilin, L, Giacca, M, Conforti, P, Cordiglieri, C, Caccia, C, Leoni, V, Taroni, F, Biella, G, Simonato, M, Cattaneo, E, Valenza, M, Birolini, Giulia, Verlengia, Gianluca, Talpo, Francesca, Maniezzi, Claudia, Zentilin, Lorena, Giacca, Mauro, Conforti, Paola, Cordiglieri, Chiara, Caccia, Claudio, Leoni, Valerio, Taroni, Franco, Biella, Gerardo, Simonato, Michele, Cattaneo, Elena, Valenza, Marta, Birolini, G, Verlengia, G, Talpo, F, Maniezzi, C, Zentilin, L, Giacca, M, Conforti, P, Cordiglieri, C, Caccia, C, Leoni, V, Taroni, F, Biella, G, Simonato, M, Cattaneo, E, Valenza, M, Birolini, Giulia, Verlengia, Gianluca, Talpo, Francesca, Maniezzi, Claudia, Zentilin, Lorena, Giacca, Mauro, Conforti, Paola, Cordiglieri, Chiara, Caccia, Claudio, Leoni, Valerio, Taroni, Franco, Biella, Gerardo, Simonato, Michele, Cattaneo, Elena, and Valenza, Marta
- Abstract
Brain cholesterol is produced mainly by astrocytes and is important for neuronal function. Its biosynthesis is severely reduced in mouse models of Huntington's disease. One possible mechanism is a diminished nuclear translocation of the transcription factor sterol regulatory element binding protein 2 (SREBP2) and, consequently, reduced activation of SREBP-controlled genes in the cholesterol biosynthesis pathway. Here we evaluated the efficacy of a gene therapy based on the unilateral intra-striatal injection of a recombinant adeno-associated virus 2/5 (AAV2/5) targeting astrocytes specifically and carrying the transcriptionally active N-terminal fragment of human SREBP2. Robust hSREBP2 expression in striatal glial cells in R6/2 Huntington's disease mice activated the transcription of cholesterol biosynthesis pathway genes, restored synaptic transmission, reversed Drd2 transcript levels decline, cleared mutant Huntingtin aggregates and attenuated behavioral deficits. We conclude that glial SREBP2 participates in Huntington's disease brain pathogenesis in vivo and that AAV-based delivery of SREBP2 to astrocytes counteracts key features of the disease.
- Published
- 2021
36. VEGF gene therapy: therapeutic angiogenesis in the clinic and beyond
- Author
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Giacca, M and Zacchigna, S
- Published
- 2012
- Full Text
- View/download PDF
37. Long-term VEGF-A expression promotes aberrant angiogenesis and fibrosis in skeletal muscle
- Author
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Karvinen, H, Pasanen, E, Rissanen, T T, Korpisalo, P, Vähäkangas, E, Jazwa, A, Giacca, M, and Ylä-Herttuala, S
- Published
- 2011
- Full Text
- View/download PDF
38. Exploiting the human amniotic fluid stem cell secretome for myocardial renewal
- Author
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Costa, A., Balbi, C., Lodder, K., Garbati, P., van Herwaarden, T., Moimas, S., Palmeri, A., De Biasio, P., Goumans, M.J., Giacca, M., Moccia, F., Smits, A.M., Barile, L., and Bollini, S.
- Published
- 2020
- Full Text
- View/download PDF
39. 545MiR-139 expression is detrimental during pressure overload-induced heart failure
- Author
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Schroen, B, Peters, T, Verhesen, W, Derks, W, Zentlini, L, Zacchigna, S, Giacca, M, Van Der Velden, J, De Windt, L, and Heymans, S
- Published
- 2014
- Full Text
- View/download PDF
40. P330Overexpression of the muscle specific chaperone Melusin delays heart failure and mortality in a mouse model of Emery Dreyfus cardiomyopathy
- Author
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Tarone, G, Cimino, J, Rubinetto, C, Moiso, E, Cristofani, F, Zentilin, L, Giacca, M, Bonne, G, and Brancaccio, M
- Published
- 2014
- Full Text
- View/download PDF
41. Gene doping using AAV vectors: S13-04
- Author
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Giacca, M.
- Published
- 2014
42. Adeno-associated viral vector-mediated human vascular endothelial growth factor gene transfer stimulates angiogenesis and wound healing in the genetically diabetic mouse
- Author
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Galeano, M., Deodato, B., Altavilla, D., Cucinotta, D., Arsic, N., Marini, H., Torre, V., Giacca, M., and Squadrito, F.
- Published
- 2003
- Full Text
- View/download PDF
43. Effect of vascular endothelial growth factor gene therapy on post-traumatic peripheral nerve regeneration and denervation-related muscle atrophy
- Author
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Moimas, S, Novati, F, Ronchi, G, Zacchigna, S, Fregnan, F, Zentilin, L, Papa, G, Giacca, M, Geuna, S, Perroteau, I, Arnezz, Z M, and Raimondo, S
- Published
- 2013
- Full Text
- View/download PDF
44. Recombinant AAV vector encoding human VEGF165 enhances wound healing
- Author
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Deodato, B, Arsic, N, Zentilin, L, Galeano, M, Santoro, D, Torre, V, Altavilla, D, Valdembri, D, Bussolino, F, Squadrito, F, and Giacca, M
- Published
- 2002
- Full Text
- View/download PDF
45. Variegation of retroviral vector gene expression in myeloid cells
- Author
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Zentilin, L, Qin, G, Tafuro, S, Dinauer, M C, Baum, C, and Giacca, M
- Published
- 2000
- Full Text
- View/download PDF
46. An unexpected link between nuclear topography and chromatin structure regulates HIV-1 integration and latency: S02.2-2
- Author
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Lusic, M., Marini, B., Ali, H., and Giacca, M.
- Published
- 2012
47. Clipper, a novel lncRNA regulating cardiomyocyte mitochondrial biogenesis and proliferation
- Author
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Ruberto, F., primary, Maric, D., additional, Tatjana, K., additional, Braga, L., additional, Nemir, M., additional, Sarre, A., additional, Manley, S., additional, Giacca, M., additional, and Pedrazzini, T., additional
- Published
- 2020
- Full Text
- View/download PDF
48. Boosting Anti-idiotype Immune Response with Recombinant AAV Enhances Tumour Protection Induced by Gene Gun Vaccination
- Author
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Cesco-Gaspere, M., Zentilin, L., Giacca, M., and Burrone, O. R.
- Published
- 2008
49. Changes in thymic function in HIV-positive patients treated with highly active antiretroviral therapy and interleukin-2
- Author
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De Paoli, P., Bortolin, M. T., Zanussi, S., Monzoni, A., Pratesi, C., and Giacca, M.
- Published
- 2001
50. Thrombospondin-1/HIV-1 Tat protein interaction: modulation of the biological activity of extracellular Tat
- Author
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RUSNATI, M., TARABOLETTI, G., URBINATI, C., TULIPANO, G., GIULIANI, R., MOLINARI-TOSATTI, M. P., SENNINO, B., GIACCA, M., TYAGI, M., ALBINI, A., NOONAN, D., GIAVAZZI, R., and PRESTA, M.
- Published
- 2000
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