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137 results on '"Giacomarra, V"'

1. Predictive Value of CD8 Expression and FoxP3 Methylation in Nasopharyngeal Carcinoma Patients Treated with Chemoradiotherapy in a Non-endemic Area

Author

Muraro, E., Vaccher, E., Furlan, C., Fratta, E., Fanetti, G., Fae’, D. A., Martorelli, D., Cangemi, M., Polesel, J., Navarria, F., Gobitti, C., Comaro, E., Scaini, C., Pratesi, C., Zanussi, S., Lupato, V., Grando, G., Giacomarra, V., Sulfaro, S., Barzan, L., Dolcetti, R., Steffan, A., Canzonieri, V., and Franchin, G.

Published
2020
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2. LINE-1 hypomethylation is associated with poor outcomes in locoregionally advanced oropharyngeal cancer

Author

Casarotto, M, Lupato, V, Giurato, G, Guerrieri, R, Sulfaro, S, Salvati, A, D'Angelo, E, Furlan, C, Menegaldo, A, Baboci, L, Montico, B, Turturici, I, Dolcetti, R, Romeo, S, Baggio, V, Corrado, S, Businello, G, Guido, M, Weisz, A, Giacomarra, V, Franchin, G, Steffan, A, Sigalotti, L, Vaccher, E, Boscolo-Rizzo, P, Jerry, P, Fanetti, G, Fratta, E, Casarotto, M, Lupato, V, Giurato, G, Guerrieri, R, Sulfaro, S, Salvati, A, D'Angelo, E, Furlan, C, Menegaldo, A, Baboci, L, Montico, B, Turturici, I, Dolcetti, R, Romeo, S, Baggio, V, Corrado, S, Businello, G, Guido, M, Weisz, A, Giacomarra, V, Franchin, G, Steffan, A, Sigalotti, L, Vaccher, E, Boscolo-Rizzo, P, Jerry, P, Fanetti, G, and Fratta, E

Abstract

BACKGROUND AND PURPOSE: Currently, human papillomavirus (HPV) positivity represents a strong prognostic factor for both reduced risk of relapse and improved survival in patients with oropharyngeal squamous cell carcinoma (OPSCC). However, a subset of HPV-positive OPSCC patients still experience poor outcomes. Furthermore, HPV-negative OPSCC patients, who have an even higher risk of relapse, are still lacking suitable prognostic biomarkers for clinical outcome. Here, we evaluated the prognostic value of LINE-1 methylation level in OPSCC patients and further addressed the relationship between LINE-1 methylation status and p53 protein expression as well as genome-wide/gene-specific DNA methylation. RESULTS: In this study, DNA was extracted from 163 formalin-fixed paraffin-embedded tissue samples retrospectively collected from stage III-IVB OPSCC patients managed with curative intent with up-front treatment. Quantitative methylation-specific PCR revealed that LINE-1 hypomethylation was directly associated with poor prognosis (5-year overall survival-OS: 28.1% for LINE-1 methylation < 35% vs. 69.1% for ≥ 55%; p < 0.0001). When LINE-1 methylation was dichotomized as < 55% versus ≥ 55%, interaction with HPV16 emerged: compared with hypermethylated HPV16-positive patients, subjects with hypomethylated HPV16-negative OPSCC reported an adjusted higher risk of death (HR 4.83, 95% CI 2.24-10.38) and progression (HR 4.54, 95% CI 2.18-9.48). Tumor protein p53 (TP53) gene is often mutated and overexpressed in HPV-negative OPSCC. Since p53 has been reported to repress LINE-1 promoter, we then analyzed the association between p53 protein expression and LINE-1 methylation levels. Following p53 immunohistochemistry, results indicated that among HPV16-negative patients with p53 ≥ 50%, LINE-1 methylation levels declined and remained stable at approximately 43%; any HPV16-positive patient reported p53 ≥ 50%. Finally, DNA methylation analysis demonstrated that genome-wide average methylat

Published
2022

4. PO-0965 Vitamin D, vitamin B12 and acute toxicity in head and neck cancer patients undergoing radiotherapy.

Author

Fanetti, G., primary, Polesel, J., additional, Matrone, F., additional, Turturici, I., additional, Gobitti, C., additional, Alfieri, S., additional, Lupato, V., additional, La Torre, F.B., additional, Fratta, E., additional, Muraro, E., additional, Casarotto, M.T., additional, Guerrieri, R., additional, Giacomarra, V., additional, Steffan, A., additional, Vaccher, E., additional, and Franchin, G., additional

Published
2021
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7. EP-1143 Regional nodal failure after primary treatment for differentiated thyroid cancer.

Author

Fanetti, G., primary, Borsatti, E., additional, Baresic, T., additional, Bampo, C., additional, Esposito, A., additional, Mazzone, S., additional, Mazzon, C., additional, Minatel, E., additional, Revelant, A., additional, Pisu, S., additional, Nappo, A., additional, Casanova Fuga, E., additional, Burello, M., additional, Giacomarra, V., additional, Franchin, G., additional, and Gobitti, C., additional

Published
2019
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8. PO-164 Regional nodal failure after primary treatment for differentiated thyroid cancer

Author

Fanetti, G., primary, Borsatti, E., additional, Baresic, T., additional, Bampo, C., additional, Esposito, A., additional, Mazzone, S., additional, Mazzon, C., additional, Minatel, E., additional, Revelant, A., additional, Pisu, S., additional, Nappo, A., additional, Fuga, E. Casanova, additional, Burello, M., additional, Giacomarra, V., additional, Franchin, G., additional, and Gobitti, C., additional

Published
2019
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9. Prognostic Significance of Immune Microenvironmental Factors in Undifferentiated Nasopharyngeal Carcinoma Patients Treated with Chemoradiotherapy

Author

Muraro, E., primary, Vaccher, E., additional, Furlan, C., additional, Fratta, E., additional, Fae', D.A., additional, Martorelli, D., additional, Polesel, J., additional, Fanetti, G., additional, Farina, E., additional, Navarria, F., additional, Comaro, E., additional, Lupato, V., additional, Giacomarra, V., additional, Sulfaro, S., additional, Barzan, L., additional, Grando, G., additional, Dolcetti, R., additional, Steffan, A., additional, Canzonieri, V., additional, and Franchin, G., additional

Published
2018
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10. Prognostic significance of LINE-1 hypomethylation in oropharyngeal squamous cell carcinoma

Author

Furlan, C, Polesel, J, Barzan, L, Franchin, G, Sulfaro, S, Romeo, S, Colizzi, F, Rizzo, A, Baggio, V, Giacomarra, V, Tos, APD, Boscolo-Rizzo, P, Vaccher, E, Dolcetti, R, Sigalotti, L, Fratta, E, Furlan, C, Polesel, J, Barzan, L, Franchin, G, Sulfaro, S, Romeo, S, Colizzi, F, Rizzo, A, Baggio, V, Giacomarra, V, Tos, APD, Boscolo-Rizzo, P, Vaccher, E, Dolcetti, R, Sigalotti, L, and Fratta, E

Abstract

BACKGROUND: Inclusion of new biomarkers to improve a personalized treatment approach for oropharyngeal squamous cell carcinoma (OPSCC) is urgently needed. Hypomethylation of the Long interspersed nucleotide element-1 (LINE-1) repetitive elements, a widely accepted surrogate of overall genomic DNA methylation content, was found to be associated with a poor prognosis in several cancers. At present, no studies have investigated the influence of LINE-1 methylation levels on OPSCC relapse. The main goal of this study was the evaluation of the prognostic value of LINE-1 methylation status in predicting early tumor relapse in locally advanced OPSCC. METHODS: We retrospectively reviewed a cohort of 77 patients with stage III-IVB OPSCC. Methylation of LINE-1 repetitive sequences was evaluated by real-time quantitative methylation-specific PCR in formalin-fixed paraffin-embedded tissues. The prognostic relevance of LINE-1 methylation was assessed by comparing patients who relapsed within 2 years from the end of treatment (cases) with those who did not (controls). Results were validated in an independent cohort of 33 patients with OPSCC. RESULTS: With respect to early OPSCC relapse, the mean LINE-1 methylation level was significantly lower in relapsed cases than in control group (p < 0.01). Interestingly, LINE-1 methylation was lower in relapsed cases than in controls in both HPV16-negative and HPV16-positive OPSCC patients, even if statistical significance was reached only for the former group (p = 0.01). LINE-1 methylation levels were also significantly reduced in relapsed cases with respect to the controls in OPSCC current smokers (p = 0.02). Consistently, in HPV16-negative current smokers, OPSCC relapse was significantly associated with decreased levels of LINE-1 methylation (p = 0.02). Using logistic regression model, we found that patients with hypomethylated LINE-1 were associated with a 3.5 higher risk of early relapse than hypermethylated ones (OR = 3.51; 95% CI 1.03

Published
2017

15. Do Ki67, S-phase, S+G2M and DNA ploidy, evaluated by flow cytometry, reveal locoregional metastasis in oral cavity and oropharynx carcinomas?

Author

Tirelli, GIAN CARLO, Sidari, L, Giacomarra, V, Papanikolla, L, Sasso, F, Russolo, Mario, Melato, Mauro, Tirelli, GIAN CARLO, Sidari, L, Giacomarra, V, Papanikolla, L, Sasso, F, Russolo, Mario, and Melato, Mauro

Subjects
oral cancer, oroharyngeal cancer
Abstract

we examine some factors like Ki67 and others by flow citometry to reveal locoregional metastases in oral and oropharyngeal cancer.

Published
2002

16. I tumori del Trigono retromolare

Author

RUSSOLO, MARIO, TIRELLI, GIAN CARLO, GIACOMARRA V, M. PIEMONTE, G. CORTESINA, Russolo, Mario, Giacomarra, V, and Tirelli, GIAN CARLO

Subjects
oral cancer
Abstract

I tumori del Trigono retromolare

Published
2002

20. Complicanze settiche del cavo orale e dell'orofaringe

Author

GIACOMARRA V, RUSSOLO, MARIO, TIRELLI, GIAN CARLO, Giacomarra, V, Russolo, Mario, and Tirelli, GIAN CARLO

Subjects
oral cavity infection
Abstract

Complicanze settiche del cavo orale e dell'orofaringe

Published
2002

22. External osteotomy i Rhinoplasty

Author

GIACOMARRA V, RUSSOLO M, ARNEZ, ZORAN MARIJ, TIRELLI, GIAN CARLO, Giacomarra, V, Russolo, M, Arnez, ZORAN MARIJ, and Tirelli, GIAN CARLO

Subjects
osotomies
Abstract

osteotomy during rhinoplasty i s a crucial phase of surgical procedure to assure a nice profile in the postsurgical aesthetic result; thera are external and internal osteotomies and we examine the two procedures; the external osteotomie gives many advantages than internal one.

Published
2001

25. External osteotomy in rhinoplasty

Author

Giacomarra, V, Russolo, Mario, Arnez, ZORAN MARIJ, Tirelli, GIAN CARLO, Bianchi, M., Giacomarra, V, Russolo, Mario, Arnez, ZORAN MARIJ, Tirelli, GIAN CARLO, and Bianchi, M.

Subjects
rhinoplasty, osteotomy
Abstract

Lateral osteotomy is a fundamental step in rhinoplasty.

Published
2000

26. Cavità orale e ghiandole salivari

Author

Russolo, Mario, Giacomarra, V, Bussani, Rossana, POZZI MUCELLI, R, Tirelli, GIAN CARLO, DESIDERIO PASSALI, Russolo, Mario, Giacomarra, V, Bussani, Rossana, POZZI MUCELLI, R, and Tirelli, GIAN CARLO

Subjects
salivary glands, oral cavity
Abstract

Cavità orale e ghiandole salivari

Published
2000

33. La glottectomia orizzontale

Author

RUSSOLO M, GIACOMARRA V, TIRELLI, GIAN CARLO, Russolo, M, Giacomarra, V, and Tirelli, GIAN CARLO

Published
1999

38. Horizzontal glottectomy

Author

Russolo, M, Giacomarra, V, Tirelli, GIAN CARLO, Russolo, M, Giacomarra, V, and Tirelli, GIAN CARLO

Published
1998

46. L'allestimento del lembo radiale

Author

Russolo, Mario, Giacomarra, V, Tirelli, GIAN CARLO, Russolo, Mario, Giacomarra, V, and Tirelli, GIAN CARLO

Subjects
microvascular flaps
Abstract

L'allestimento del lembo radiale

Published
1996

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