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4. IL-10 dampens antitumor immunity and promotes liver metastasis via PD-L1 induction

Author

Shiri, Ahmad Mustafa, Zhang, Tao, Bedke, Tanja, Zazara, Dimitra E., Zhao, Lilan, Lücke, Jöran, Sabihi, Morsal, Fazio, Antonella, Zhang, Siwen, Tauriello, Daniele V.F., Batlle, Eduard, Steglich, Babett, Kempski, Jan, Agalioti, Theodora, Nawrocki, Mikołaj, Xu, Yang, Riecken, Kristoffer, Liebold, Imke, Brockmann, Leonie, Konczalla, Leonie, Bosurgi, Lidia, Mercanoglu, Baris, Seeger, Philipp, Küsters, Natalie, Lykoudis, Panagis M., Heumann, Asmus, Arck, Petra C., Fehse, Boris, Busch, Philipp, Grotelüschen, Rainer, Mann, Oliver, Izbicki, Jakob R., Hackert, Thilo, Flavell, Richard A., Gagliani, Nicola, Giannou, Anastasios D., and Huber, Samuel

Published
2024
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5. IL-22 promotes liver regeneration after portal vein ligation

Author

Zhang, Tao, Seeger, Philipp, Simsek, Yashin, Sabihi, Morsal, Lücke, Jöran, Zazara, Dimitra E., Shiri, Ahmad Mustafa, Kempski, Jan, Blankenburg, Tom, Zhao, Lilan, Belios, Ioannis, Machicote, Andres, Mercanoglu, Baris, Fard-Aghaie, Mohammad, Notz, Sara, Lykoudis, Panagis M., Kemper, Marius, Ghadban, Tarik, Mann, Oliver, Hackert, Thilo, Izbicki, Jakob R., Renné, Thomas, Huber, Samuel, Giannou, Anastasios D., and Li, Jun

Published
2024
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6. Obesity and diabetes mellitus are associated with SARS-CoV-2 outcomes without influencing signature genes of extrapulmonary immune compartments at the RNA level

Author

Lücke, Jöran, Böttcher, Marius, Nawrocki, Mikolaj, Meins, Nicholas, Schnell, Josa, Heinrich, Fabian, Bertram, Franziska, Sabihi, Morsal, Seeger, Philipp, Pfaff, Marie, Notz, Sara, Blankenburg, Tom, Zhang, Tao, Kempski, Jan, Reeh, Matthias, Wolter, Stefan, Mann, Oliver, Lütgehetmann, Marc, Hackert, Thilo, Izbicki, Jakob R., Duprée, Anna, Huber, Samuel, Ondruschka, Benjamin, and Giannou, Anastasios D.

Published
2024
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7. HLA-DP on Epithelial Cells Enables Tissue Damage by NKp44+ Natural Killer Cells in Ulcerative Colitis

Author

Akar, Alaa, Flemming, Cornelius, Felix, Flomm, Flosbach, Markus, Jäger, Julia, Jeromin, Niklas, Jung, Johannes, Ohms, Mareike, Reinshagen, Konrad, Rische, Johann, Sagebiel, Adrian, Sandfort, Deborah, Steinert, Fenja, Tomuschat, Christian, Wesche, Jasmin, Shifteh Abedian, Abraham, Clara, Achkar, Jean-Paul, Ahmad, Tariq, Alberts, Rudi, Alizadeh, Behrooz, Amininejad, Leila, Ananthakrishnan, Ashwin N., Andersen, Vibeke, Anderson, Carl A., Andrews, Jane M., Annese, Vito, Aumais, Guy, Baidoo, Leonard, Baldassano, Robert N., Bampton, Peter A., Barclay, Murray, Barrett, Jeffrey C., Bethge, Johannes, Bewshea, Claire, Bis, Joshua C., Bitton, Alain, BK, Thelma, Boucher, Gabrielle, Brain, Oliver, Brand, Stephan, Brant, Steven R., Cheon, Jae Hee, Chew, Angela, Cho, Judy H., Cleynen, Isabelle, Cohain, Ariella, Cooney, Rachel, Croft, Anthony, Daly, Mark J., D'Amato, Mauro, Danese, Silvio, Daryani, Naser Ebrahim, Datta, Lisa Wu, Degenhardt, Frauke, Denapiene, Goda, Denson, Lee A., Devaney, Kathy L., Dewit, Olivier, D'Inca, Renata, Drummond, Hazel E., Dubinsky, Marla, Duerr, Richard H., Edwards, Cathryn, Ellinghaus, David, Ellul, Pierre, Esaki, Motohiro, Essers, Jonah, Ferguson, Lynnette R., Festen, Eleonora A., Fleshner, Philip, Florin, Tim, Franchimont, Denis, Franke, Andre, Fuyuno, Yuta, Gearry, Richard, Georges, Michel, Gieger, Christian, Glas, Jürgen, Goyette, Philippe, Green, Todd, Griffiths, Anne M., Guthery, Stephen L., Hakonarson, Hakon, Halfvarson, Jonas, Hanigan, Katherine, Haritunians, Talin, Hart, Ailsa, Hawkey, Chris, Hayward, Nicholas K., Hedl, Matija, Henderson, Paul, Hold, Georgina L., Hong, Myhunghee, Hu, Xinli, Huang, Hailiang, Hugot, Jean-Pierre, Hui, Ken Y., Imielinski, Marcin, Jazayeri, Omid, Jonaitis, Laimas, Jostins, Luke, Juyal, Garima, Chandra Juyal, Ramesh, Kalla, Rahul, Karlsen, Tom H., Kennedy, Nicholas A., Khan, Mohammed Azam, Kim, Won Ho, Kitazono, Takanari, Kiudelis, Gediminas, Kubo, Michiaki, Kugathasan, Subra, Kupcinskas, Limas, Lamb, Christopher A., de Lange, Katrina M., Latiano, Anna, Laukens, Debby, Lawrance, Ian C., Lee, James C., Lees, Charlie W., Leja, Marcis, Lewis, Nina, Van Limbergen, Johan, Lionetti, Paolo, Liu, Jimmy Z., Louis, Edouard, Luo, Yang, Mahy, Gillian, Malekzadeh, Masoud Mohammad, Malekzadeh, Reza, Mansfield, John, Marriott, Suzie, Massey, Dunecan, Mathew, Christopher G., Matsui, Toshiyuki, McGovern, Dermot P.B., van der Meulen, Andrea, Midha, Vandana, Milgrom, Raquel, Mirzaei, Samaneh, Mitrovic, Mitja, Montgomery, Grant W., Mowat, Craig, Müller, Christoph, Newman, William G., Ng, Aylwin, Ng, Siew C., Evelyn Ng, Sok Meng, Nikolaus, Susanna, Ning, Kaida, Nöthen, Markus, Oikonomou, Ioannis, Okou, David, Orchard, Timothy R., Palmieri, Orazio, Parkes, Miles, Phillips, Anne, Ponsioen, Cyriel Y., Potocnik, Urõs, Poustchi, Hossein, Prescott, Natalie J., Proctor, Deborah D., Radford-Smith, Graham, Rahier, Jean- Francois, Regueiro, Miguel, Reinisch, Walter, Rieder, Florian, Rioux, John D., Roberts, Rebecca, Rogler, Gerhard, Russell, Richard K., Sanderson, Jeremy D., Sans, Miquel, Satsangi, Jack, Schadt, Eric E., Scharl, Michael, Schembri, John, Schreiber, Stefan, Schumm, L. Philip, Scott, Regan, Seielstad, Mark, Shah, Tejas, Sharma, Yashoda, Silverberg, Mark S., Simmons, Alison, Simms, Lisa A., Singh, Abhey, Skieceviciene, Jurgita, van Sommeren, Suzanne, Song, Kyuyoung, Sood, Ajit, Spain, Sarah L., Steinhart, A. Hillary, Stempak, Joanne M., Stronati, Laura, Sung, Joseph J.Y., Targan, Stephan R., Taylor, Kirstin M., Theatre, Emilie, Torkvist, Leif, Torres, Esther A., Tremelling, Mark, Uhlig, Holm H., Umeno, Junji, Vahedi, Homayon, Vasiliauskas, Eric, Velde, Anje ter, Ventham, Nicholas T., Vermeire, Severine, Verspaget, Hein W., De Vos, Martine, Walters, Thomas, Wang, Kai, Wang, Ming-Hsi, Weersma, Rinse K., Wei, Zhi, Whiteman, David, Wijmenga, Cisca, Wilson, David C., Winkelmann, Juliane, Wong, Sunny H., Xavier, Ramnik J., Yamazaki, Keiko, Yang, Suk-Kyun, Ye, Byong Duk, Zeissig, Sebastian, Zhang, Bin, Zhang, Clarence K., Zhang, Hu, Zhang, Wei, Zhao, Hongyu, Zhao, Zhen Z., Baumdick, Martin E., Niehrs, Annika, Schwerk, Maria, Hinrichs, Ole, Jordan-Paiz, Ana, Padoan, Benedetta, Wegner, Lucy H.M., Schloer, Sebastian, Zecher, Britta F., Malsy, Jakob, Joshi, Vinita R., Illig, Christin, Schröder-Schwarz, Jennifer, Möller, Kimberly J., Martin, Maureen P., Yuki, Yuko, Ozawa, Mikki, Sauter, Jürgen, Schmidt, Alexander H., Perez, Daniel, Giannou, Anastasios D., Carrington, Mary, Davis, Randall S., Schumacher, Udo, Sauter, Guido, Huber, Samuel, Puelles, Victor G., Melling, Nathaniel, Altfeld, Marcus, and Bunders, Madeleine J.

Published
2023
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8. Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer

Author

Tintelnot, Joseph, Xu, Yang, Lesker, Till R., Schönlein, Martin, Konczalla, Leonie, Giannou, Anastasios D., Pelczar, Penelope, Kylies, Dominik, Puelles, Victor G., Bielecka, Agata A., Peschka, Manuela, Cortesi, Filippo, Riecken, Kristoffer, Jung, Maximilian, Amend, Lena, Bröring, Tobias S., Trajkovic-Arsic, Marija, Siveke, Jens T., Renné, Thomas, Zhang, Danmei, Boeck, Stefan, Strowig, Till, Uzunoglu, Faik G., Güngör, Cenap, Stein, Alexander, Izbicki, Jakob R., Bokemeyer, Carsten, Sinn, Marianne, Kimmelman, Alec C., Huber, Samuel, and Gagliani, Nicola

Published
2023
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9. Intestinal B cells license metabolic T-cell activation in NASH microbiota/antigen-independently and contribute to fibrosis by IgA-FcR signalling

Author

Kotsiliti, Elena, Leone, Valentina, Schuehle, Svenja, Govaere, Olivier, Li, Hai, Wolf, Monika J., Horvatic, Helena, Bierwirth, Sandra, Hundertmark, Jana, Inverso, Donato, Zizmare, Laimdota, Sarusi-Portuguez, Avital, Gupta, Revant, O’Connor, Tracy, Giannou, Anastasios D., Shiri, Ahmad Mustafa, Schlesinger, Yehuda, Beccaria, Maria Garcia, Rennert, Charlotte, Pfister, Dominik, Öllinger, Rupert, Gadjalova, Iana, Ramadori, Pierluigi, Rahbari, Mohammad, Rahbari, Nuh, Healy, Marc E., Fernández-Vaquero, Mirian, Yahoo, Neda, Janzen, Jakob, Singh, Indrabahadur, Fan, Chaofan, Liu, Xinyuan, Rau, Monika, Feuchtenberger, Martin, Schwaneck, Eva, Wallace, Sebastian J., Cockell, Simon, Wilson-Kanamori, John, Ramachandran, Prakash, Kho, Celia, Kendall, Timothy J., Leblond, Anne-Laure, Keppler, Selina J., Bielecki, Piotr, Steiger, Katja, Hofmann, Maike, Rippe, Karsten, Zitzelsberger, Horst, Weber, Achim, Malek, Nisar, Luedde, Tom, Vucur, Mihael, Augustin, Hellmut G., Flavell, Richard, Parnas, Oren, Rad, Roland, Pabst, Olivier, Henderson, Neil C., Huber, Samuel, Macpherson, Andrew, Knolle, Percy, Claassen, Manfred, Geier, Andreas, Trautwein, Christoph, Unger, Kristian, Elinav, Eran, Waisman, Ari, Abdullah, Zeinab, Haller, Dirk, Tacke, Frank, Anstee, Quentin M., and Heikenwalder, Mathias

Published
2023
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12. Automatic Semi-quantitative Histological Assessment of Tissue Traits Using a Smart Web Application

Author

Giannou, Olympia, Zazara, Dimitra E., Giannou, Anastasios D., Arck, Petra Clara, Pavlidis, Georgios, Rannenberg, Kai, Editor-in-Chief, Soares Barbosa, Luís, Editorial Board Member, Goedicke, Michael, Editorial Board Member, Tatnall, Arthur, Editorial Board Member, Neuhold, Erich J., Editorial Board Member, Stiller, Burkhard, Editorial Board Member, Tröltzsch, Fredi, Editorial Board Member, Pries-Heje, Jan, Editorial Board Member, Kreps, David, Editorial Board Member, Reis, Ricardo, Editorial Board Member, Furnell, Steven, Editorial Board Member, Mercier-Laurent, Eunika, Editorial Board Member, Winckler, Marco, Editorial Board Member, Malaka, Rainer, Editorial Board Member, Maglogiannis, Ilias, editor, Iliadis, Lazaros, editor, Macintyre, John, editor, and Cortez, Paulo, editor

Published
2022
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13. Tissue resident iNKT17 cells facilitate cancer cell extravasation in liver metastasis via interleukin-22

Author

Giannou, Anastasios D., Kempski, Jan, Shiri, Ahmad Mustafa, Lücke, Jöran, Zhang, Tao, Zhao, Lilan, Zazara, Dimitra E., Cortesi, Filippo, Riecken, Kristoffer, Amezcua Vesely, Maria Carolina, Low, Jun Siong, Xu, Hao, Kaffe, Eleanna, Garcia-Perez, Laura, Agalioti, Theodora, Yamada, Yoshito, Jungraithmayr, Wolfgang, Zigmond, Ehud, Karstens, Karl-Frederick, Steglich, Babett, Wagner, Jonas, Konczalla, Leonie, Carambia, Antonella, Schulze, Kornelius, von Felden, Johann, May, Peter, Briukhovetska, Daria, Bedke, Tanja, Brockmann, Leonie, Starzonek, Sarah, Lange, Tobias, Koch, Claudia, Riethdorf, Sabine, Pelczar, Penelope, Böttcher, Marius, Sabihi, Morsal, Huber, Francis J., Reeh, Matthias, Grass, Julia Kristin, Wahib, Ramez, Seese, Hannes, Stüben, Björn-Ole, Fard-Aghaie, Mohammad, Duprée, Anna, Scognamiglio, Pasquale, Plitzko, Gabriel, Meiners, Jan, Soukou, Shiwa, Wittek, Agnes, Manthey, Caroline, Maroulis, Ioannis C., Arck, Petra C., Perez, Daniel, Gao, Bin, Zarogiannis, Sotirios G., Strowig, Till, Pasqualini, Renata, Arap, Wadih, Gosálvez, Javier Suárez, Kobold, Sebastian, Prinz, Immo, Guse, Andreas H., Tachezy, Michael, Ghadban, Tarik, Heumann, Asmus, Li, Jun, Melling, Nathaniel, Mann, Oliver, Izbicki, Jakob R., Pantel, Klaus, Schumacher, Udo, Lohse, Ansgar W., Flavell, Richard A., Gagliani, Nicola, and Huber, Samuel

Published
2023
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14. T cell-derived interleukin-22 drives the expression of CD155 by cancer cells to suppress NK cell function and promote metastasis

Author

Briukhovetska, Daria, Suarez-Gosalvez, Javier, Voigt, Cornelia, Markota, Anamarija, Giannou, Anastasios D., Schübel, Maryam, Jobst, Jakob, Zhang, Tao, Dörr, Janina, Märkl, Florian, Majed, Lina, Müller, Philipp Jie, May, Peter, Gottschlich, Adrian, Tokarew, Nicholas, Lücke, Jöran, Oner, Arman, Schwerdtfeger, Melanie, Andreu-Sanz, David, Grünmeier, Ruth, Seifert, Matthias, Michaelides, Stefanos, Hristov, Michael, König, Lars M., Cadilha, Bruno Loureiro, Mikhaylov, Oleg, Anders, Hans-Joachim, Rothenfusser, Simon, Flavell, Richard A., Cerezo-Wallis, Daniela, Tejedo, Cristina, Soengas, María S., Bald, Tobias, Huber, Samuel, Endres, Stefan, and Kobold, Sebastian

Published
2023
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15. Liver Cancer Trait Detection and Classification Through Machine Learning on Smart Mobile Devices

Author

Giannou, Olympia, Giannou, Anastasios D., Zazara, Dimitra E., Kleinschmidt, Dörte, Mummert, Tobias, Stüben, Björn Ole, Kaul, Michael Gerhard, Adam, Gerhard, Huber, Samuel, Pavlidis, Georgios, Angelov, Plamen, Series Editor, Kozma, Robert, Series Editor, Iliadis, Lazaros, editor, Macintyre, John, editor, Jayne, Chrisina, editor, and Pimenidis, Elias, editor

Published
2021
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17. Short Term Exposure of Sheep Tracheal Epithelium to Cigarette Smoke Extract Reduces ENaC Current: A Pilot Study.

Author

JAGIRDAR, RAJESH M., GRAMMATIKOPOULOS, ALEXANDROS, IOANNOU, MARIA, SOLENOV, EVGENIY, GOURGOULIANIS, KONSTANTINOS I., HATZOGLOU, CHRISSI, GIANNOU, ANASTASIOS D., MERCANOGLOU, BARIS, and ZAROGIANNIS, SOTIRIOS G.

Abstract

Background/Aim: Cigarette smoke has been shown to induce a phenotype in humans known as “acquired cystic fibrosis”. This occurs because the cystic fibrosis transmembrane conductance regulator (CFTR) functions are impaired systemically due to the deleterious effects of smoke components. Elucidation of cigarette smoke effects on the tracheal epithelium is important. The aim of this study was to develop an ex vivo sheep tracheal model to investigate tracheal ion function. In this model, the epithelial sodium channel (ENaC) is inhibited after exposure to cigarette smoke extract (CSE) as a proof of principle. Materials and Methods: Tracheas were isolated from healthy sheep and the tracheal epithelium was surgically excised. Tissues were mounted in Ussing chambers and the short circuit current (Isc) was measured after incubation with 5% CSE in PBS or PBS alone for 30 min. The function of ENaC was investigated by the addition of amiloride (10–5M) apically. Western blot analysis was performed to assess differences in ENaC quantity after CSE exposure. Some specimens were stained with H&E for detection of histological alterations. Results: The amiloride effect on normal epithelium led to a significant decrease in Isc [ΔI=33±5.92 μA/cm²; p<0.001 versus control experiments (ΔI=1.44±0.71 μA/cm²)]. After incubation with CSE, ENaC Isc was significantly reduced (ΔI=14.80±1.96 μA/cm²; p<0.001). No differences in αENaC expression were observed between CSE-exposed and normal tracheal epithelium. Histological images post CSE incubation revealed decreases in the height of the epithelium, with basal cell hyperplasia and loss of ciliated cells. Conclusion: Reduced ENaC inhibition by amiloride after CSE incubation could be due to alterations in the tracheal epithelium. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Group 3 Innate Lymphoid Cells Program a Distinct Subset of IL-22BP-Producing Dendritic Cells Demarcating Solitary Intestinal Lymphoid Tissues

Author

Guendel, Fabian, Kofoed-Branzk, Michael, Gronke, Konrad, Tizian, Caroline, Witkowski, Mario, Cheng, Hung-Wei, Heinz, Gitta Anne, Heinrich, Frederik, Durek, Pawel, Norris, Paula S., Ware, Carl F., Ruedl, Christiane, Herold, Susanne, Pfeffer, Klaus, Hehlgans, Thomas, Waisman, Ari, Becher, Burkhard, Giannou, Anastasios D., Brachs, Sebastian, Ebert, Karolina, Tanriver, Yakup, Ludewig, Burkhard, Mashreghi, Mir-Farzin, Kruglov, Andrey A., and Diefenbach, Andreas

Published
2020
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19. IL22BP Mediates the Antitumor Effects of Lymphotoxin Against Colorectal Tumors in Mice and Humans

Author

Kempski, Jan, Giannou, Anastasios D., Riecken, Kristoffer, Zhao, Lilan, Steglich, Babett, Lücke, Jöran, Garcia-Perez, Laura, Karstens, Karl-Frederick, Wöstemeier, Anna, Nawrocki, Mikolaj, Pelczar, Penelope, Witkowski, Mario, Nilsson, Sven, Konczalla, Leonie, Shiri, Ahmad Mustafa, Kempska, Joanna, Wahib, Ramez, Brockmann, Leonie, Huber, Philipp, Gnirck, Ann-Christin, Turner, Jan-Eric, Zazara, Dimitra E., Arck, Petra C., Stein, Alexander, Simon, Ronald, Daubmann, Anne, Meiners, Jan, Perez, Daniel, Strowig, Till, Koni, Pandelakis, Kruglov, Andrey A., Sauter, Guido, Izbicki, Jakob R., Guse, Andreas H., Rösch, Thomas, Lohse, Ansgar W., Flavell, Richard A., Gagliani, Nicola, and Huber, Samuel

Published
2020
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20. IgG Fc sialylation is regulated during the germinal center reaction following immunization with different adjuvants

Author

Bartsch, Yannic C., Eschweiler, Simon, Leliavski, Alexei, Lunding, Hanna B., Wagt, Sander, Petry, Janina, Lilienthal, Gina-Maria, Rahmöller, Johann, de Haan, Noortje, Hölscher, Alexandra, Erapaneedi, Raghu, Giannou, Anastasios D., Aly, Lilian, Sato, Ryota, de Neef, Louise A., Winkler, André, Braumann, Dominique, Hobusch, Juliane, Kuhnigk, Kyra, Krémer, Vanessa, Steinhaus, Moritz, Blanchard, Véronique, Gemoll, Timo, Habermann, Jens K., Collin, Mattias, Salinas, Gabriela, Manz, Rudolf A., Fukuyama, Hidehiro, Korn, Thomas, Waisman, Ari, Yogev, Nir, Huber, Samuel, Rabe, Björn, Rose-John, Stefan, Busch, Hauke, Berberich-Siebelt, Friederike, Hölscher, Christoph, Wuhrer, Manfred, and Ehlers, Marc

Published
2020
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24. A Comprehensive Analysis of Tn and STn Antigen Expression in Esophageal Adenocarcinoma

Author

Mercanoglu, Baris, primary, Karstens, Karl-Frederick, additional, Giannou, Anastasios D., additional, Meiners, Jan, additional, Lücke, Jöran, additional, Seeger, Philipp, additional, Brackrock, Vera, additional, Güngör, Cenap, additional, Izbicki, Jakob R., additional, Bockhorn, Maximilian, additional, Hackert, Thilo, additional, Melling, Nathaniel, additional, and Wolters-Eisfeld, Gerrit, additional

Published
2024
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26. Protocol for orthotopic single-lung transplantation in mice as a tool for lung metastasis studies

Author

Giannou, Anastasios D., primary, Ohm, Birte, additional, Zazara, Dimitra E., additional, Lücke, Jöran, additional, Zhang, Tao, additional, Sabihi, Morsal, additional, Seeger, Philipp, additional, Oh, Jun, additional, Grotelüschen, Rainer, additional, Busch, Philipp, additional, Mann, Oliver, additional, Hackert, Thilo, additional, Izbicki, Jakob R., additional, Yamada, Yoshito, additional, Huber, Samuel, additional, and Jungraithmayr, Wolfgang, additional

Published
2023
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27. CD4+ T cell-derived IL-22 enhances liver metastasis by promoting angiogenesis

Author

Zhang, Tao, primary, Wahib, Ramez, additional, Zazara, Dimitra E., additional, Lücke, Jöran, additional, Shiri, Ahmad Mustafa, additional, Kempski, Jan, additional, Zhao, Lilan, additional, Agalioti, Theodora, additional, Machicote, Andres Pablo, additional, Giannou, Olympia, additional, Belios, Ioannis, additional, Jia, Rongrong, additional, Zhang, Siwen, additional, Tintelnot, Joseph, additional, Seese, Hannes, additional, Grass, Julia Kristin, additional, Mercanoglu, Baris, additional, Stern, Louisa, additional, Scognamiglio, Pasquale, additional, Fard-Aghaie, Mohammad, additional, Seeger, Philipp, additional, Wakker, Jonas, additional, Kemper, Marius, additional, Brunswig, Benjamin, additional, Duprée, Anna, additional, Lykoudis, Panagis M., additional, Pikouli, Anastasia, additional, Giorgakis, Emmanouil, additional, Stringa, Pablo, additional, Lausada, Natalia, additional, Gentilini, Maria Virginia, additional, Gondolesi, Gabriel E., additional, Bachmann, Kai, additional, Busch, Philipp, additional, Grotelüschen, Rainer, additional, Maroulis, Ioannis C., additional, Arck, Petra C., additional, Nakano, Ryosuke, additional, Thomson, Angus W., additional, Ghadban, Tarik, additional, Tachezy, Michael, additional, Melling, Nathaniel, additional, Achilles, Eike-Gert, additional, Puelles, Victor G., additional, Nickel, Felix, additional, Hackert, Thilo, additional, Mann, Oliver, additional, Izbicki, Jakob R., additional, Li, Jun, additional, Gagliani, Nicola, additional, Huber, Samuel, additional, and Giannou, Anastasios D., additional

Published
2023
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28. Intestinal IL-1β Plays a Role in Protecting against SARS-CoV-2 Infection

Author

Lücke, Jöran, primary, Heinrich, Fabian, additional, Malsy, Jakob, additional, Meins, Nicholas, additional, Schnell, Josa, additional, Böttcher, Marius, additional, Nawrocki, Mikolaj, additional, Zhang, Tao, additional, Bertram, Franziska, additional, Sabihi, Morsal, additional, Kempski, Jan, additional, Blankenburg, Tom, additional, Duprée, Anna, additional, Reeh, Matthias, additional, Wolter, Stefan, additional, Mann, Oliver, additional, Izbicki, Jakob R., additional, Lohse, Ansgar W., additional, Gagliani, Nicola, additional, Lütgehetmann, Marc, additional, Bunders, Madeleine J., additional, Altfeld, Marcus, additional, Sauter, Guido, additional, Giannou, Anastasios D., additional, Krasemann, Susanne, additional, Ondruschka, Benjamin, additional, and Huber, Samuel, additional

Published
2023
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32. IL-22BP controls the progression of liver metastasis in colorectal cancer

Author

Giannou, Anastasios D., primary, Kempski, Jan, additional, Zhang, Tao, additional, Lücke, Jöran, additional, Shiri, Ahmad Mustafa, additional, Zazara, Dimitra E., additional, Belios, Ioannis, additional, Machicote, Andres, additional, Seeger, Philipp, additional, Agalioti, Theodora, additional, Tintelnot, Joseph, additional, Sagebiel, Adrian, additional, Tomczak, Miriam, additional, Bauditz, Lennart, additional, Bedke, Tanja, additional, Kocheise, Lorenz, additional, Mercanoglu, Baris, additional, Fard-Aghaie, Mohammad, additional, Giorgakis, Emmanouil, additional, Lykoudis, Panagis M., additional, Pikouli, Anastasia, additional, Grass, Julia-Kristin, additional, Wahib, Ramez, additional, Bardenhagen, Jan, additional, Brunswig, Benjamin, additional, Heumann, Asmus, additional, Ghadban, Tarik, additional, Duprée, Anna, additional, Tachezy, Michael, additional, Melling, Nathaniel, additional, Arck, Petra C., additional, Stringa, Pablo, additional, Gentilini, Maria Virginia, additional, Gondolesi, Gabriel E., additional, Nakano, Ryosuke, additional, Thomson, Angus W., additional, Perez, Daniel, additional, Li, Jun, additional, Mann, Oliver, additional, Izbicki, Jakob R., additional, Gagliani, Nicola, additional, Maroulis, Ioannis C., additional, and Huber, Samuel, additional

Published
2023
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33. Protocol for orthotopic single-lung transplantation in mice as a tool for lung metastasis studies

Author

Giannou, Anastasios D, Ohm, Birte, Zazara, Dimitra E, Lücke, Jöran, Zhang, Tao, Sabihi, Morsal, Seeger, Philipp, Oh, Jun, Grotelüschen, Rainer, Busch, Philipp, Mann, Oliver, Hackert, Thilo, Izbicki, Jakob R, Yamada, Yoshito, Huber, Samuel, Jungraithmayr, Wolfgang; https://orcid.org/0000-0002-1442-4862, Giannou, Anastasios D, Ohm, Birte, Zazara, Dimitra E, Lücke, Jöran, Zhang, Tao, Sabihi, Morsal, Seeger, Philipp, Oh, Jun, Grotelüschen, Rainer, Busch, Philipp, Mann, Oliver, Hackert, Thilo, Izbicki, Jakob R, Yamada, Yoshito, Huber, Samuel, and Jungraithmayr, Wolfgang; https://orcid.org/0000-0002-1442-4862

Abstract

The transplantation model provides the opportunity to assess the relevance of a molecule of interest for tumor cell extravasation by using a respective genetically modified donor animal. Here, we present a protocol for orthotopic single-lung transplantation in mice as a tool for lung metastasis studies. We describe steps for animal preparation, lung transplantation, and tumor cell injection. We then detail procedures for the direct comparison of tumor cell spreading between the genetically modified left lung and the naive right lung parenchyma. For complete details on the use and execution of this protocol, please refer to Giannou et al. (2023).

Published
2023

34. TNFα aggravates detrimental effects of SARS-CoV-2 infection in the liver

Author

Lücke, Jöran, primary, Nawrocki, Mikolaj, additional, Schnell, Josa, additional, Meins, Nicholas, additional, Heinrich, Fabian, additional, Zhang, Tao, additional, Bertram, Franziska, additional, Sabihi, Morsal, additional, Böttcher, Marius, additional, Blankenburg, Tom, additional, Pfaff, Marie, additional, Notz, Sara, additional, Kempski, Jan, additional, Reeh, Matthias, additional, Wolter, Stefan, additional, Mann, Oliver, additional, Izbicki, Jakob R., additional, Lütgehetmann, Marc, additional, Duprée, Anna, additional, Giannou, Anastasios D., additional, Ondruschka, Benjamin, additional, and Huber, Samuel, additional

Published
2023
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35. Multicytokine-producing CD4+ T cells characterize the livers of patients with NASH

Author

Woestemeier, Anna, primary, Scognamiglio, Pasquale, additional, Zhao, Yu, additional, Wagner, Jonas, additional, Muscate, Franziska, additional, Casar, Christian, additional, Siracusa, Francesco, additional, Cortesi, Filippo, additional, Agalioti, Theodora, additional, Müller, Simone, additional, Sagebiel, Adrian, additional, Konczalla, Leonie, additional, Wahib, Ramez, additional, Karstens, Karl-Frederick, additional, Giannou, Anastasios D., additional, Duprée, Anna, additional, Wolter, Stefan, additional, Wong, Milagros N., additional, Mühlig, Anne K., additional, Bielecka, Agata A., additional, Bansal, Vikas, additional, Zhang, Tianran, additional, Mann, Oliver, additional, Puelles, Victor G., additional, Huber, Tobias B., additional, Lohse, Ansgar W., additional, Izbicki, Jakob R., additional, Palm, Noah W., additional, Bonn, Stefan, additional, Huber, Samuel, additional, and Gagliani, Nicola, additional

Published
2023
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36. Il-22 Promotes Liver Regeneration after Portal Vein Ligation

Author

Zhang, Tao, primary, Seeger, Philipp, additional, Simsek, Yashin, additional, Sabihi, Morsal, additional, Lücke, Jöran, additional, Zazara, Dimitra E., additional, Shiri, Ahmad Mustafa, additional, Kempski, Jan, additional, Blankenburg, Tom, additional, Zhao, Lilan, additional, Belios, Ioannis, additional, Machicote, Andres, additional, Mercanoglu, Baris, additional, Fard-Aghaie, Mohammad, additional, Notz, Sara, additional, Lykoudis, Panagis M., additional, Kemper, Marius, additional, Ghadban, Tarik, additional, Mann, Oliver, additional, Hackert, Thilo, additional, Izbicki, Jakob R., additional, Renné, Thomas, additional, Huber, Samuel, additional, Giannou, Anastasios D., additional, and Li, Jun, additional

Published
2023
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37. NRAS destines tumor cells to the lungs

Author

Giannou, Anastasios D, Marazioti, Antonia, Kanellakis, Nikolaos I, Giopanou, Ioanna, Lilis, Ioannis, Zazara, Dimitra E, Ntaliarda, Giannoula, Kati, Danai, Armenis, Vasileios, Giotopoulou, Georgia A, Krontira, Anthi C, Lianou, Marina, Agalioti, Theodora, Vreka, Malamati, Papageorgopoulou, Maria, Fouzas, Sotirios, Kardamakis, Dimitrios, Psallidas, Ioannis, Spella, Magda, and Stathopoulos, Georgios T

Published
2017
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38. A Critical Role of the IL-22–IL-22 Binding Protein Axis in Hepatocellular Carcinoma

Author

Giannou, Anastasios D., primary, Lücke, Jöran, additional, Kleinschmidt, Dörte, additional, Shiri, Ahmad Mustafa, additional, Steglich, Babett, additional, Nawrocki, Mikolaj, additional, Zhang, Tao, additional, Zazara, Dimitra E., additional, Kempski, Jan, additional, Zhao, Lilan, additional, Giannou, Olympia, additional, Agalioti, Theodora, additional, Brockmann, Leonie, additional, Bertram, Franziska, additional, Sabihi, Morsal, additional, Böttcher, Marius, additional, Ewald, Florian, additional, Schulze, Kornelius, additional, von Felden, Johann, additional, Machicote, Andres, additional, Maroulis, Ioannis C., additional, Arck, Petra C., additional, Graß, Julia-Kristin, additional, Mercanoglu, Baris, additional, Reeh, Matthias, additional, Wolter, Stefan, additional, Tachezy, Michael, additional, Seese, Hannes, additional, Theodorakopoulou, Myrto, additional, Lykoudis, Panagis M., additional, Heumann, Asmus, additional, Uzunoglu, Faik G., additional, Ghadban, Tarik, additional, Mann, Oliver, additional, Izbicki, Jakob R., additional, Li, Jun, additional, Duprée, Anna, additional, Melling, Nathaniel, additional, Gagliani, Nicola, additional, and Huber, Samuel, additional

Published
2022
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39. Mast cells mediate malignant pleural effusion formation

Author

Giannou, Anastasios D., Marazioti, Antonia, Spella, Magda, Kanellakis, Nikolaos I., Apostolopoulou, Hara, Psallidas, Ioannis, Prijovich, Zeljko M., Vreka, Malamati, Zazara, Dimitra E., Lilis, Ioannis, Papaleonidopoulos, Vassilios, Kairi, Chrysoula A., Patmanidi, Alexandra L., Giopanou, Ioanna, Spiropoulou, Nikolitsa, Harokopos, Vaggelis, Aidinis, Vassilis, Spyratos, Dionisios, Teliousi, Stamatia, Papadaki, Helen, Taraviras, Stavros, Snyder, Linda A., Eickelberg, Oliver, Kardamakis, Dimitrios, Iwakura, Yoichiro, Feyerabend, Thorsten B., Rodewald, Hans-Reimer, Kalomenidis, Ioannis, Blackwell, Timothy S., Agalioti, Theodora, and Stathopoulos, Georgios T.

Subjects
Pleural effusion -- Genetic aspects -- Care and treatment -- Research, Mast cells -- Physiological aspects -- Research, Health care industry
Abstract

Mast cells (MCs) have been identified in various tumors; however, the role of these cells in tumorigenesis remains controversial. Here, we quantified MCs in human and murine malignant pleural effusions (MPEs) and evaluated the fate and function of these cells in MPE development. Evaluation of murine MPE-competent lung and colon adenocarcinomas revealed that these tumors actively attract and subsequently degranulate MCs in the pleural space by elaborating CCL2 and osteopontin. MCs were required for effusion development, as MPEs did not form in mice lacking MCs, and pleural infusion of MCs with MPE-incompetent cells promoted MPE formation. Once homed to the pleural space, MCs released tryptase AB1 and IL-1[beta], which in turn induced pleural vasculature leakiness and triggered NF-[kappa]B activation in pleural tumor cells, thereby fostering pleural fluid accumulation and tumor growth. Evaluation of human effusions revealed that MCs are elevated in MPEs compared with benign effusions. Moreover, MC abundance correlated with MPE formation in a human cancer cell-induced effusion model. Treatment of mice with the c-KIT inhibitor imatinib mesylate limited effusion precipitation by mouse and human adenocarcinoma cells. Together, the results of this study indicate that MCs are required for MPE formation and suggest that MC-dependent effusion formation is therapeutically addressable., Introduction Inflammation was recently recognized as an enabling hallmark of cancer that may mediate tumor growth and dissemination instead of tumor eradication (1). Inflammatory signaling networks in the tumor microenvironment [...]

Published
2015
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40. Efferocytosis fuels malignant pleural effusion through TIMP1

Author

Zhao, Lilan, primary, Giannou, Anastasios D., additional, Xu, Yang, additional, Shiri, Ahmad Mustafa, additional, Liebold, Imke, additional, Steglich, Babett, additional, Bedke, Tanja, additional, Zhang, Tao, additional, Lücke, Jöran, additional, Scognamiglio, Pasquale, additional, Kempski, Jan, additional, Woestemeier, Anna, additional, Chen, Jing, additional, Agalioti, Theodora, additional, Zazara, Dimitra E., additional, Lindner, Diana, additional, Janning, Melanie, additional, Hennigs, Jan K., additional, Jagirdar, Rajesh M., additional, Kotsiou, Ourania S., additional, Zarogiannis, Sotirios G., additional, Kobayashi, Yasushi, additional, Izbicki, Jacob R., additional, Ghosh, Sourav, additional, Rothlin, Carla V., additional, Bosurgi, Lidia, additional, Huber, Samuel, additional, and Gagliani, Nicola, additional

Published
2021
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43. Systemic interleukin 10 levels indicate advanced stages while interleukin 17A levels correlate with reduced survival in esophageal adenocarcinomas

Author

Karstens, Karl-Frederick, primary, Kempski, Jan, additional, Giannou, Anastasios D., additional, Freiwald, Erik, additional, Reeh, Matthias, additional, Tachezy, Michael, additional, Izbicki, Jakob R., additional, Lohse, Ansgar W., additional, Gagliani, Nicola, additional, Huber, Samuel, additional, and Pelczar, Penelope, additional

Published
2020
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44. Rationalizing heptadecaphobia: TH17 cells and associated cytokines in cancer and metastasis.

Author

Lücke, Jöran, Shiri, Ahmad Mustafa, Zhang, Tao, Kempski, Jan, Giannou, Anastasios D., and Huber, Samuel

Subjects
METASTASIS, T helper cells, CYTOTOXIC T cells, INNATE lymphoid cells, CYTOKINES, RETINOIC acid receptors
Abstract

Cancer is one of the leading causes of death worldwide. When cancer patients are diagnosed with metastasis, meaning that the primary tumor has spread to at least one different site, their life expectancy decreases dramatically. In the past decade, the immune system´s role in fighting cancer and metastasis has been studied extensively. Importantly, immune cells and inflammatory reactions generate potent antitumor responses but also contribute to tumor development. However, the molecular and cellular mechanisms underlying this dichotomic interaction between the immune system and cancer are still poorly understood. Recently, a spotlight has been cast on the distinct subsets of immune cells and their derived cytokines since evidence has implicated their crucial impact on cancer development. T helper 17 cell (TH17) cells, which express the master transcriptional factor Retinoic acid‐receptor‐related orphan receptor gamma t, are among these critical cell subsets and are defined by their production of type 3 cytokines, such as IL‐17A, IL‐17F, and IL‐22. Depending on the tumor microenvironment, these cytokines can also be produced by other immune cell sources, such as T cytotoxic 17 cell, innate lymphoid cells, NKT cells, or γδ T cells. To date, a lot of data have been collected describing the divergent functions of IL‐17A, IL‐17F, and IL‐22 in malignancies. In this comprehensive review, we discuss the role of these TH17‐ and non‐TH17‐derived type 3 cytokines in different tumor entities. Furthermore, we will provide a structured insight into the strict regulation and subsequent downstream mechanisms of these cytokines in cancer and metastasis. [ABSTRACT FROM AUTHOR]

Published
2021
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45. Osteopontin drives KRAS-mutant lung adenocarcinoma

Author

Giopanou, Ioanna, primary, Kanellakis, Nikolaos I, additional, Giannou, Anastasios D, additional, Lilis, Ioannis, additional, Marazioti, Antonia, additional, Spella, Magda, additional, Papaleonidopoulos, Vassilios, additional, Simoes, Davina C M, additional, Zazara, Dimitra E, additional, Agalioti, Theodora, additional, Moschos, Charalampos, additional, Magkouta, Sophia, additional, Kalomenidis, Ioannis, additional, Panoutsakopoulou, Vily, additional, Lamort, Anne-Sophie, additional, Stathopoulos, Georgios T, additional, and Psallidas, Ioannis, additional

Published
2019
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47. Club cells form lung adenocarcinomas and maintain the alveoli of adult mice

Author

Spella, Magda, primary, Lilis, Ioannis, additional, Pepe, Mario AA, additional, Chen, Yuanyuan, additional, Armaka, Maria, additional, Lamort, Anne-Sophie, additional, Zazara, Dimitra E, additional, Roumelioti, Fani, additional, Vreka, Malamati, additional, Kanellakis, Nikolaos I, additional, Wagner, Darcy E, additional, Giannou, Anastasios D, additional, Armenis, Vasileios, additional, Arendt, Kristina AM, additional, Klotz, Laura V, additional, Toumpanakis, Dimitrios, additional, Karavana, Vassiliki, additional, Zakynthinos, Spyros G, additional, Giopanou, Ioanna, additional, Marazioti, Antonia, additional, Aidinis, Vassilis, additional, Sotillo, Rocio, additional, and Stathopoulos, Georgios T, additional

Published
2019
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48. Author response: Club cells form lung adenocarcinomas and maintain the alveoli of adult mice

Author

Spella, Magda, primary, Lilis, Ioannis, additional, Pepe, Mario AA, additional, Chen, Yuanyuan, additional, Armaka, Maria, additional, Lamort, Anne-Sophie, additional, Zazara, Dimitra E, additional, Roumelioti, Fani, additional, Vreka, Malamati, additional, Kanellakis, Nikolaos I, additional, Wagner, Darcy E, additional, Giannou, Anastasios D, additional, Armenis, Vasileios, additional, Arendt, Kristina AM, additional, Klotz, Laura V, additional, Toumpanakis, Dimitrios, additional, Karavana, Vassiliki, additional, Zakynthinos, Spyros G, additional, Giopanou, Ioanna, additional, Marazioti, Antonia, additional, Aidinis, Vassilis, additional, Sotillo, Rocio, additional, and Stathopoulos, Georgios T, additional

Published
2019
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49. Tobacco chemical-induced mouse lung adenocarcinoma cell lines pin the prolactin orthologue proliferin as a lung tumour promoter

Author

Kanellakis, Nikolaos I, primary, Giannou, Anastasios D, additional, Pepe, Mario A A, additional, Agalioti, Theodora, additional, Zazara, Dimitra E, additional, Giopanou, Ioanna, additional, Psallidas, Ioannis, additional, Spella, Magda, additional, Marazioti, Antonia, additional, Arendt, Kristina A M, additional, Lamort, Anne Sophie, additional, Champeris Tsaniras, Spyridon, additional, Taraviras, Stavros, additional, Papadaki, Helen, additional, Lilis, Ioannis, additional, and Stathopoulos, Georgios T, additional

Published
2019
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50. Dual airway and alveolar contributions to adult lung homeostasis and carcinogenesis

Author

Spella, Magda, primary, Lilis, Ioannis, additional, Pepe, Mario A., additional, Chen, Yuanyuan, additional, Armaka, Maria, additional, Lamort, Anne-Sophie, additional, Zazara, Dimitra E., additional, Roumelioti, Fani, additional, Vreka, Malamati, additional, Kanellakis, Nikolaos I., additional, Wagner, Darcy E., additional, Giannou, Anastasios D., additional, Armenis, Vasileios, additional, Arendt, Kristina A.M., additional, Klotz, Laura V., additional, Toumpanakis, Dimitrios, additional, Karavana, Vassiliki, additional, Zakynthinos, Spyros G., additional, Giopanou, Ioanna, additional, Marazioti, Antonia, additional, Aidinis, Vassilis, additional, Sotillo, Rocio, additional, and Stathopoulos, Georgios T., additional

Published
2019
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