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712 results on '"Gianolli L."'

1. 68Ga-DOTATOC PET/MR imaging and radiomic parameters in predicting histopathological prognostic factors in patients with pancreatic neuroendocrine well-differentiated tumours

Author

Mapelli, P., Bezzi, C., Palumbo, D., Canevari, C., Ghezzo, S., Samanes Gajate, A. M., Catalfamo, B., Messina, A., Presotto, L., Guarnaccia, A., Bettinardi, V., Muffatti, F., Andreasi, V., Schiavo Lena, M., Gianolli, L., Partelli, S., Falconi, M., Scifo, P., De Cobelli, F., and Picchio, M.

Published
2022
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3. Worldwide Variation in the Use of Nuclear Cardiology Camera Technology, Reconstruction Software, and Imaging Protocols

Author

Einstein, A.J., Pascual, T.N.B., Paez, D., Dondi, M., Better, N., Bouyoucef, S.E., Karthikeyan, G., Kashyap, R., Lele, V., Magboo, V.P.C., Mahmarian, J.J., Meeks, J.B., Mercuri, M., Mut, F., Rehani, M.M., Vitola, J.V., Alexanderson, E., Allam, A., Al-Mallah, M.H., Bom, H., Flotats, A., Jerome, S., Kaufmann, P.A., Luxenburg, O., Mahmarian, J., Shaw, L.J., Underwood, S.R., Vitola, J., Amouri, W., Essabbah, H., Gassama, S.S., Makhdomi, K.B., El Mustapha, G.I.E., El Ouchdi, N., Qaïs, N., Soni, N., Vangu, W., Abazid, R.M., Adams, B., Agarwal, V., Alfeeli, M.A., Alnafisi, N., Bernabe, L., Bural, G.G., Chaiwatanarat, T., Chandraguptha, J.M., Cheon, G.J., Cho, I., Dogan, A.S., Eftekhari, M., Frenkel, A., Garty, I., George, S., Geramifar, P., Golan, H., Habib, S., Hussain, R., Im, H., Jeon, H.-J., Kalawat, T., Kang, W.J., Keng, F., Klaipetch, A., Kumar, P.G., Lee, J., Lee, W.W., Lim, I., Macaisa, C.M.M., Malhotra, G., Mittal, B.R., Mohammad, M.H., Mohan, P., Mulyanto, I.D., Nariman, D., Nayak, U.N., Niaz, K., Nikolov, G., Obaldo, J.M., Ozturk, E., Park, J.M., Park, S., Patel, C.D., Phuong, H.K., Quinon, A.P., Rajini, T.R., Saengsuda, Y., Santiago, J., Sayman, H.B., Shinto, A.S., Sivasubramaniyan, V., Son, M.H., Sudhakar, P., Syed, G.M.S., Tamaki, N., Thamnirat, K., Thientunyakit, T., Thongmak, S., Velasco, D.N., Verma, A., Vutrapongwatana, U., Wang, Y., Won, K.S., Yao, Z., Yingsa-nga, T., Yudistiro, R., Yue, K.T., Zafrir, N., Adrian, S.C., Agostini, D., Aguadé, S., Armitage, G., Backlund, M., Backman, M., Baker, M., Balducci, M.T., Bavelaar, C., Berovic, M., Bertagna, F., Beuchel, R., Biggi, A., Bisi, G., Bonini, R., Bradley, A., Brudin, L., Bruno, I., Busnardo, E., Casoni, R., Choudhri, A., Cittanti, C., Clauss, R., Costa, D.C., Costa, M., Dixon, K., Dziuk, M., Egelic, N., Eriksson, I., Fagioli, G., de Faria, D.B., Florimonte, L., Francini, A., French, M., Gallagher, E., Garai, I., Geatti, O., Genovesi, D., Gianolli, L., Gimelli, A., Giudice, E. del, Halliwell, S., Hansson, M.J., Harrison, C., Homans, F., Horton, F., Jędrzejuk, D., Jogi, J., Johansen, A., Johansson, H., Kalnina, M., Kaminek, M., Kiss, A., Kobylecka, M., Kostkiewicz, M., Kropp, J., Kullenberg, R., Lahoutte, T., Lang, O., Larsson, Y.H., Lázár, M., Leccisotti, L., Leners, N., Lindner, O., Lipp, R.W., Maenhout, A., Maffioli, L., Marcassa, C., Martins, B., Marzullo, P., Medolago, G., Mendiguchía, C.G., Mirzaei, S., Mori, M., Nardi, B., Nazarenko, S., Nikoletic, K., Oleksa, R., Parviainen, T., Patrina, J., Peace, R., Pirich, C., Piwowarska-Bilska, H., Popa, S., Prakash, V., Pubul, V., Puklavec, L., Rac, S., Ratniece, M., Rogan, S.A., Romeo, A., Rossi, M., Ruiz, D., Sabharwal, N., Salobir, B.G., Santos, A.I., Saranovic, S., Sarkozi, A., Schneider, R.P., Sciagra, R., Scotti, S., Servini, Z., Setti, L.R., Starck, S.-Å., Vajauskas, D., Veselý, J., Vieni, A., Vignati, A., Vito, I.M., Weiss, K., Wild, D., Zdraveska-Kochovska, M., Agüro, R.N., Alvarado, N., Barral, C.M., Beretta, M., Berrocal, I., Cuellar, J.F. Batista, Cabral Chang, T.-M., Cabrera Rodríguez, L.O., Canessa, J., Castro Mora, G., Claudia, A.C., Clavelo, G.F., Júnior, A.F. Cruz, Faccio, F.F., Fernández, K.M., Garibo, J.R. Gomez, Gonzalez, U., González E, P., Guzzo, M.A., Jofre, J., Kapitán, M., Kempfer, G., Lopez, J.L., Massardo V, T., Medeiros Colaco, I., Mesquita, C.T., Montecinos, M., Neubauer, S., Pabon, L.M., Puente, A., Rochela Vazquez, L.M., Serna Macias, J.A., Silva Pino, A.G., Huber, F.Z. Tártari, Tovar, A.P., Vargas, L., Wiefels, C., Aljizeeri, A., Alvarez, R.J., Barger, D., Beardwood, W., Behrens, J., Brann, L., Brown, D., Carr, H., Churchwell, K., Comingore, G.A., Corbett, J., Costello, M., Cruz, F., Depinet, T., Dorbala, S., Earles, M., Esteves, F.P., Etherton, E., Fanning, R.J., Jr., Fornace, J., Franks, L., Gewirtz, H., Gulanchyn, K., Hannah, C.-L., Hays, J., Hendrickson, J., Hester, J., Holmes, K., Johnson, A., Jopek, C., Lewin, H., Lyons, J., Manley, C., Meden, J., Moore, S., Moore, W.H., Murthy, V., Nace, R., Neely, D., Nelson, L., Niedermaier, O., Rice, D., Rigs, R., Schiffer, K., Schockling, E., Schultz, T., Schumacker, T., Sheesley, B., Sheikh, A., Siegel, B., Slim, A.M., Smith, J., Szulc, M., Tanskersley, N., Tilkemeier, P., Valdez, G.D., Vrooman, R., Wawrowicz, D., Winchester, D.E., Alcheikh, A., Allen, B., Atkins, E., Bevan, J., Bonomini, C., Christiansen, J., Clack, L., Craig, E., Dixson, H., Duncan, I., Fredericks, S., Gales, S., Hampson, R., Hanley, T., Hartcher, K., Hassall, J., Kelley, B., Kelly, S., Kidd, T., de Kort, T., Larcos, G., Macdonald, W., McGrath, C., Murdoch, E., O'Malley, S., O'Rourke, M., Pack, M., Pearce, R., Praehofer, R., Ramsay, S., Scarlett, L., Smidt, K., Souvannavong, F., Taubman, K., Taylor, G., Tse, K., Unger, S., Weale, J., Hirschfeld, Cole B., Mercuri, Mathew, Pascual, Thomas N.B., Karthikeyan, Ganesan, Vitola, João V., Mahmarian, John J., Better, Nathan, Bouyoucef, Salah E., Hee-Seung Bom, Henry, Lele, Vikram, Magboo, V. Peter C., Alexánderson, Erick, Allam, Adel H., Al-Mallah, Mouaz H., Dorbala, Sharmila, Flotats, Albert, Jerome, Scott, Kaufmann, Philipp A., Luxenburg, Osnat, Shaw, Leslee J., Underwood, S. Richard, Rehani, Madan M., Paez, Diana, Dondi, Maurizio, and Einstein, Andrew J.

Published
2021
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4. Worldwide Diagnostic Reference Levels for Single-Photon Emission Computed Tomography Myocardial Perfusion Imaging: Findings From INCAPS

Author

Einstein, A.J., Pascual, T.N.B., Paez, D., Dondi, M., Better, N., Bouyoucef, S.E., Karthikeyan, G., Kashyap, R., Lele, V., Magboo, V.P.C., Mahmarian, J.J., Meeks, J.B., Mercuri, M., Mut, F., Rehani, M.M., Vitola, J.V., Alexanderson, E., Allam, A., Al-Mallah, M.H., Bom, H., Flotats, A., Jerome, S., Kaufmann, P.A., Luxenburg, O., Mahmarian, J., Shaw, L.J., Underwood, S.R., Vitola, J., Amouri, W., Essabbah, H., Gassama, S.S., Makhdomi, K.B., El Mustapha, G.I.E., El Ouchdi, N., Qaïs, N., Soni, N., Vangu, W., Abazid, R.M., Adams, B., Agarwal, V., Alfeeli, M.A., Alnafisi, N., Bernabe, L., Bural, G.G., Chaiwatanarat, T., Chandraguptha, J.M., Cheon, G.J., Cho, I., Dogan, A.S., Eftekhari, M., Frenkel, A., Garty, I., George, S., Geramifar, P., Golan, H., Habib, S., Hussain, R., Im, H., Jeon, H.-J., Kalawat, T., Kang, W.J., Keng, F., Klaipetch, A., Kumar, P.G., Lee, J., Lee, W.W., Lim, I., Macaisa, C.M.M., Malhotra, G., Mittal, B.R., Mohammad, M.H., Mohan, P., Mulyanto, I.D., Nariman, D., Nayak, U.N., Niaz, K., Nikolov, G., Obaldo, J.M., Ozturk, E., Park, J.M., Park, S., Patel, C.D., Phuong, H.K., Quinon, A.P., Rajini, T.R., Saengsuda, Y., Santiago, J., Sayman, H.B., Shinto, A.S., Sivasubramaniyan, V., Son, M.H., Sudhakar, P., Syed, G.M.S., Tamaki, N., Thamnirat, K., Thientunyakit, T., Thongmak, S., Velasco, D.N., Verma, A., Vutrapongwatana, U., Wang, Y., Won, K.S., Yao, Z., Yingsa-nga, T., Yudistiro, R., Yue, K.T., Zafrir, N., Adrian, S.C., Agostini, D., Aguadé, S., Armitage, G., Backlund, M., Backman, M., Baker, M., Balducci, M.T., Bavelaar, C., Berovic, M., Bertagna, F., Beuchel, R., Biggi, A., Bisi, G., Bonini, R., Bradley, A., Brudin, L., Bruno, I., Busnardo, E., Casoni, R., Choudhri, A., Cittanti, C., Clauss, R., Costa, D.C., Costa, M., Dixon, K., Dziuk, M., Egelic, N., Eriksson, I., Fagioli, G., de Faria, D.B., Florimonte, L., Francini, A., French, M., Gallagher, E., Garai, I., Geatti, O., Genovesi, D., Gianolli, L., Gimelli, A., del Giudice, E., Halliwell, S., Hansson, M.J., Harrison, C., Homans, F., Horton, F., Jędrzejuk, D., Jogi, J., Johansen, A., Johansson, H., Kalnina, M., Kaminek, M., Kiss, A., Kobylecka, M., Kostkiewicz, M., Kropp, J., Kullenberg, R., Lahoutte, T., Lang, O., Larsson, Y.H., Lázár, M., Leccisotti, L., Leners, N., Lindner, O., Lipp, R.W., Maenhout, A., Maffioli, L., Marcassa, C., Martins, B., Marzullo, P., Medolago, G., Mendiguchía, C.G., Mirzaei, S., Mori, M., Nardi, B., Nazarenko, S., Nikoletic, K., Oleksa, R., Parviainen, T., Patrina, J., Peace, R., Pirich, C., Piwowarska-Bilska, H., Popa, S., Prakash, V., Pubul, V., Puklavec, L., Rac, S., Ratniece, M., Rogan, S.A., Romeo, A., Rossi, M., Ruiz, D., Sabharwal, N., Salobir, B.G., Santos, A.I., Saranovic, S., Sarkozi, A., Schneider, R.P., Sciagra, R., Scotti, S., Servini, Z., Setti, L.R., Starck, S.-Å., Vajauskas, D., Veselý, J., Vieni, A., Vignati, A., Vito, I.M., Weiss, K., Wild, D., Zdraveska-Kochovska, M., Agüro, R.N., Alvarado, N., Barral, C.M., Beretta, M., Berrocal, I., Cuellar, J.F. Batista, Chang, T-M. Cabral, Rodríguez, L.O. Cabrera, Canessa, J., Mora, G. Castro, Claudia, A.C., Clavelo, G.F., Júnior, A.F. Cruz, Faccio, F.F., Fernández, K.M., Garibo, J.R. Gomez, Gonzalez, U., González E, P., Guzzo, M.A., Jofre, J., Kapitán, M., Kempfer, G., Lopez, J.L., Massardo V, T., Colaco, I. Medeiros, Mesquita, C.T., Montecinos, M., Neubauer, S., Pabon, L.M., Puente, A., Vazquez, L.M. Rochela, Macias, J.A. Serna, Pino, A.G. Silva, Huber, F.Z. Tártari, Tovar, A.P., Vargas, L., Wiefels, C., Aljizeeri, A., Alvarez, R.J., Barger, D., Beardwood, W., Behrens, J., Brann, L., Brown, D., Carr, H., Churchwell, K., Comingore, G.A., Corbett, J., Costello, M., Cruz, F., Depinet, T., Dorbala, S., Earles, M., Esteves, F.P., Etherton, E., Fanning, R.J., Jr., Fornace, J., Franks, L., Gewirtz, H., Gulanchyn, K., Hannah, C.-L., Hays, J., Hendrickson, J., Hester, J., Holmes, K., Johnson, A., Jopek, C., Lewin, H., Lyons, J., Manley, C., Meden, J., Moore, S., Moore, W.H., Murthy, V., Nace, R., Neely, D., Nelson, L., Niedermaier, O., Rice, D., Rigs, R., Schiffer, K., Schockling, E., Schultz, T., Schumacker, T., Sheesley, B., Sheikh, A., Siegel, B., Slim, A.M., Smith, J., Szulc, M., Tanskersley, N., Tilkemeier, P., Valdez, G.D., Vrooman, R., Wawrowicz, D., Winchester, D.E., Alcheikh, A., Allen, B., Atkins, E., Bevan, J., Bonomini, C., Christiansen, J., Clack, L., Craig, E., Dixson, H., Duncan, I., Fredericks, S., Gales, S., Hampson, R., Hanley, T., Hartcher, K., Hassall, J., Kelley, B., Kelly, S., Kidd, T., de Kort, T., Larcos, G., Macdonald, W., McGrath, C., Murdoch, E., O'Malley, S., O'Rourke, M., Pack, M., Pearce, R., Praehofer, R., Ramsay, S., Scarlett, L., Smidt, K., Souvannavong, F., Taubman, K., Taylor, G., Tse, K., Unger, S., Weale, J., Hirschfeld, Cole B., Dondi, Maurizio, Pascual, Thomas N.B., Mercuri, Mathew, Vitola, Joao, Karthikeyan, Ganesan, Better, Nathan, Mahmarian, John J., Bouyoucef, Salah E., Hee-Seung Bom, Henry, Lele, Vikram, Magboo, Vincent Peter C., Alexánderson, Erick, Allam, Adel H., Al-Mallah, Mouaz H., Flotats, Albert, Jerome, Scott, Kaufmann, Philipp A., Luxenburg, Osnat, Underwood, S. Richard, Rehani, Madan M., Vassileva, Jenia, Paez, Diana, and Einstein, Andrew J.

Published
2021
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11. Gender Differences in Radiation Dose From Nuclear Cardiology Studies Across the World: Findings From the INCAPS Registry

Author

Einstein, A.J., Pascual, T.N.B., Paez, D., Dondi, M., Better, N., Bouyoucef, S.E., Karthikeyan, G., Kashyap, R., Lele, V., Magboo, V.P.C., Mahmarian, J.J., Meeks, J.B., Mercuri, M., Mut, F., Rehani, M.M., Vitola, J.V., Alexanderson, E., Allam, A., Al-Mallah, M.H., Bom, H., Flotats, A., Jerome, S., Kaufmann, P.A., Luxenburg, O., Mahmarian, J., Shaw, L.J., Underwood, S.R., Vitola, J., Amouri, W., Essabbah, H., Gassama, S.S., Makhdomi, K.B., El Mustapha, G.I.E., El Ouchdi, N., Qaïs, N., Soni, N., Vangu, W., Abazid, R.M., Adams, B., Agarwal, V., Alfeeli, M.A., Alnafisi, N., Bernabe, L., Bural, G.G., Chaiwatanarat, T., Chandraguptha, J.M., Cheon, G.J., Cho, I., Dogan, A.S., Eftekhari, M., Frenkel, A., Garty, I., George, S., Geramifar, P., Golan, H., Habib, S., Hussain, R., Im, H., Jeon, H.-J., Kalawat, T., Kang, W.J., Keng, F., Klaipetch, A., Kumar, P.G., Lee, J., Lee, W.W., Lim, I., Macaisa, C.M.M., Malhotra, G., Mittal, B.R., Mohammad, M.H., Mohan, P., Mulyanto, I.D., Nariman, D., Nayak, U.N., Niaz, K., Nikolov, G., Obaldo, J.M., Ozturk, E., Park, J.M., Park, S., Patel, C.D., Phuong, H.K., Quinon, A.P., Rajini, T.R., Saengsuda, Y., Santiago, J., Sayman, H.B., Shinto, A.S., Sivasubramaniyan, V., Son, M.H., Sudhakar, P., Syed, G.M.S., Tamaki, N., Thamnirat, K., Thientunyakit, T., Thongmak, S., Velasco, D.N., Verma, A., Vutrapongwatana, U., Wang, Y., Won, K.S., Yao, Z., Yingsa-nga, T., Yudistiro, R., Yue, K.T., Zafrir, N., Adrian, S.C., Agostini, D., Aguadé, S., Armitage, G., Backlund, M., Backman, M., Baker, M., Balducci, M.T., Bavelaar, C., Berovic, M., Bertagna, F., Beuchel, R., Biggi, A., Bisi, G., Bonini, R., Bradley, A., Brudin, L., Bruno, I., Busnardo, E., Casoni, R., Choudhri, A., Cittanti, C., Clauss, R., Costa, D.C., Costa, M., Dixon, K., Dziuk, M., Egelic, N., Eriksson, I., Fagioli, G., de Faria, D.B., Florimonte, L., Francini, A., French, M., Gallagher, E., Garai, I., Geatti, O., Genovesi, D., Gianolli, L., Gimelli, A., del Giudice, E., Halliwell, S., Hansson, M.J., Harrison, C., Homans, F., Horton, F., Jędrzejuk, D., Jogi, J., Johansen, A., Johansson, H., Kalnina, M., Kaminek, M., Kiss, A., Kobylecka, M., Kostkiewicz, M., Kropp, J., Kullenberg, R., Lahoutte, T., Lang, O., Larsson, Y.H., Lázár, M., Leccisotti, L., Leners, N., Lindner, O., Lipp, R.W., Maenhout, A., Maffioli, L., Marcassa, C., Martins, B., Marzullo, P., Medolago, G., Mendiguchía, C.G., Mirzaei, S., Mori, M., Nardi, B., Nazarenko, S., Nikoletic, K., Oleksa, R., Parviainen, T., Patrina, J., Peace, R., Pirich, C., Piwowarska-Bilska, H., Popa, S., Prakash, V., Pubul, V., Puklavec, L., Rac, S., Ratniece, M., Rogan, S.A., Romeo, A., Rossi, M., Ruiz, D., Sabharwal, N., Salobir, B.G., Santos, A.I., Saranovic, S., Sarkozi, A., Schneider, R.P., Sciagra, R., Scotti, S., Servini, Z., Setti, L.R., Starck, S.-Å., Vajauskas, D., Veselý, J., Vieni, A., Vignati, A., Vito, I.M., Weiss, K., Wild, D., Zdraveska-Kochovska, M., Agüro, R.N., Alvarado, N., Barral, C.M., Beretta, M., Berrocal, I., Batista Cuellar, J.F., Cabral Chang, T.-M., Cabrera Rodríguez, L.O., Canessa, J., Castro Mora, G., Claudia, A.C., Clavelo, G.F., Cruz Júnior, A.F., Faccio, F.F., Fernández, K.M., Gomez Garibo, J.R., Gonzalez, U., González E., P., Guzzo, M.A., Jofre, J., Kapitán, M., Kempfer, G., Lopez, J.L., Massardo V., T., Medeiros Colaco, I., Mesquita, C.T., Montecinos, M., Neubauer, S., Pabon, L.M., Puente, A., Rochela Vazquez, L.M., Serna Macias, J.A., Silva Pino, A.G., Tártari Huber, F.Z., Tovar, A.P., Vargas, L., Wiefels, C., Aljizeeri, A., Alvarez, R.J., Barger, D., Beardwood, W., Behrens, J., Brann, L., Brown, D., Carr, H., Churchwell, K., Comingore, G.A., Corbett, J., Costello, M., Cruz, F., Depinet, T., Dorbala, S., Earles, M., Esteves, F.P., Etherton, E., Fanning, R.J., Jr., Fornace, J., Franks, L., Gewirtz, H., Gulanchyn, K., Hannah, C.-L., Hays, J., Hendrickson, J., Hester, J., Holmes, K., Johnson, A., Jopek, C., Lewin, H., Lyons, J., Manley, C., Meden, J., Moore, S., Moore, W.H., Murthy, V., Nace, R., Neely, D., Nelson, L., Niedermaier, O., Rice, D., Rigs, R., Schiffer, K., Schockling, E., Schultz, T., Schumacker, T., Sheesley, B., Sheikh, A., Siegel, B., Slim, A.M., Smith, J., Szulc, M., Tanskersley, N., Tilkemeier, P., Valdez, G.D., Vrooman, R., Wawrowicz, D., Winchester, D.E., Alcheikh, A., Allen, B., Atkins, E., Bevan, J., Bonomini, C., Christiansen, J., Clack, L., Craig, E., Dixson, H., Duncan, I., Fredericks, S., Gales, S., Hampson, R., Hanley, T., Hartcher, K., Hassall, J., Kelley, B., Kelly, S., Kidd, T., de Kort, T., Larcos, G., Macdonald, W., McGrath, C., Murdoch, E., O'Malley, S., O'Rourke, M., Pack, M., Pearce, R., Praehofer, R., Ramsay, S., Scarlett, L., Smidt, K., Souvannavong, F., Taubman, K., Taylor, G., Tse, K., Unger, S., Weale, J., Shi, Lynn, Dorbala, Sharmila, Paez, Diana, Shaw, Leslee J., Zukotynski, Katherine A., Pascual, Thomas N.B., Karthikeyan, Ganesan, Vitola, João V., Better, Nathan, Bokhari, Nadia, Rehani, Madan M., Kashyap, Ravi, Dondi, Maurizio, Mercuri, Mathew, and Einstein, Andrew J.

Published
2016
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12. 68Ga-DOTATOC PET/MR imaging and radiomic parameters in predicting histopathological prognostic factors in patients with pancreatic neuroendocrine well-differentiated tumours

Author

Mapelli, P, Bezzi, C, Palumbo, D, Canevari, C, Ghezzo, S, Samanes Gajate, A, Catalfamo, B, Messina, A, Presotto, L, Guarnaccia, A, Bettinardi, V, Muffatti, F, Andreasi, V, Schiavo Lena, M, Gianolli, L, Partelli, S, Falconi, M, Scifo, P, De Cobelli, F, Picchio, M, Mapelli P., Bezzi C., Palumbo D., Canevari C., Ghezzo S., Samanes Gajate A. M., Catalfamo B., Messina A., Presotto L., Guarnaccia A., Bettinardi V., Muffatti F., Andreasi V., Schiavo Lena M., Gianolli L., Partelli S., Falconi M., Scifo P., De Cobelli F., Picchio M., Mapelli, P, Bezzi, C, Palumbo, D, Canevari, C, Ghezzo, S, Samanes Gajate, A, Catalfamo, B, Messina, A, Presotto, L, Guarnaccia, A, Bettinardi, V, Muffatti, F, Andreasi, V, Schiavo Lena, M, Gianolli, L, Partelli, S, Falconi, M, Scifo, P, De Cobelli, F, Picchio, M, Mapelli P., Bezzi C., Palumbo D., Canevari C., Ghezzo S., Samanes Gajate A. M., Catalfamo B., Messina A., Presotto L., Guarnaccia A., Bettinardi V., Muffatti F., Andreasi V., Schiavo Lena M., Gianolli L., Partelli S., Falconi M., Scifo P., De Cobelli F., and Picchio M.

Abstract

Purpose: To explore the role of fully hybrid 68Ga-DOTATOC PET/MR imaging and radiomic parameters in predicting histopathological prognostic factors in patients with pancreatic neuroendocrine tumours (PanNETs) undergoing surgery. Methods: One hundred eighty-seven consecutive 68Ga-DOTATOC PET/MRI scans (March 2018–June 2020) performed for gastroenteropancreatic neuroendocrine tumour were retrospectively evaluated; 16/187 patients met the eligibility criteria (68Ga-DOTATOC PET/MRI for preoperative staging of PanNET and availability of histological data). PET/MR scans were qualitatively and quantitatively interpreted, and the following imaging parameters were derived: PET-derived SUVmax, SUVmean, somatostatin receptor density (SRD), total lesion somatostatin receptor density (TLSRD), and MRI-derived apparent diffusion coefficient (ADC), arterial and late enhancement, necrosis, cystic degeneration, and maximum diameter. Additionally, first-, second-, and higher-order radiomic parameters were extracted from both PET and MRI scans. Correlations with several PanNETs’ histopathological prognostic factors were evaluated using Spearman’s coefficient, while the area under the curve (AUC) of the receiver operating characteristic (ROC) curve was used to evaluate parameters’ predictive performance. Results: Primary tumour was detected in all 16 patients (15/16 by 68Ga-DOTATOC PET and 16/16 by MRI). SUVmax and SUVmean resulted good predictors of lymphnodal (LN) involvement (AUC of 0.850 and 0.783, respectively). Second-order radiomic parameters GrayLevelVariance and HighGrayLevelZoneEmphasis extracted from T2 MRI demonstrated significant correlations with LN involvement (adjusted p = 0.009), also showing good predictive performance (AUC = 0.992). Conclusion: This study demonstrates the role of the fully hybrid PET/MRI tool for the synergic function of imaging parameters extracted by the two modalities and highlights the potentiality of imaging and radiomic parameters in assessing h

Published
2022

20. Preliminary results of an ongoing prospective clinical trial on the use of68ga-psma and68ga-dota-rm2 pet/mri in staging of high-risk prostate cancer patients

Author

Mapelli, P, Ghezzo, S, Samanes Gajate, A, Preza, E, Brembilla, G, Cucchiara, V, Ahmed, N, Bezzi, C, Presotto, L, Bettinardi, V, Savi, A, Magnani, P, Menichini, R, Coliva, A, Neri, I, Di Gaeta, E, Gianolli, L, Freschi, M, Briganti, A, De Cobelli, F, Scifo, P, Picchio, M, Mapelli P., Ghezzo S., Samanes Gajate A. M., Preza E., Brembilla G., Cucchiara V., Ahmed N., Bezzi C., Presotto L., Bettinardi V., Savi A., Magnani P., Menichini R., Coliva A., Neri I., Di Gaeta E., Gianolli L., Freschi M., Briganti A., De Cobelli F., Scifo P., Picchio M., Mapelli, P, Ghezzo, S, Samanes Gajate, A, Preza, E, Brembilla, G, Cucchiara, V, Ahmed, N, Bezzi, C, Presotto, L, Bettinardi, V, Savi, A, Magnani, P, Menichini, R, Coliva, A, Neri, I, Di Gaeta, E, Gianolli, L, Freschi, M, Briganti, A, De Cobelli, F, Scifo, P, Picchio, M, Mapelli P., Ghezzo S., Samanes Gajate A. M., Preza E., Brembilla G., Cucchiara V., Ahmed N., Bezzi C., Presotto L., Bettinardi V., Savi A., Magnani P., Menichini R., Coliva A., Neri I., Di Gaeta E., Gianolli L., Freschi M., Briganti A., De Cobelli F., Scifo P., and Picchio M.

Abstract

The aim of the present study is to investigate the synergic role of68Ga-PSMA PET/MRI and68Ga-DOTA-RM2 PET/MRI in prostate cancer (PCa) staging. We present pilot data on twenty-two patients with biopsy-proven PCa that underwent68Ga-PSMA PET/MRI for staging purposes, with 19/22 also undergoing68Gaa-DOTA-RM2 PET/MRI. TNM classification based on image findings was performed and quantitative imaging parameters were collected for each scan. Furthermore, twelve patients underwent radical prostatectomy with the availability of histological data that were used as the gold standard to validate intraprostatic findings. A DICE score between regions of interest manually segmented on the primary tumour on68Ga-PSMA PET,68Ga-DOTA-RM2 PET and on T2 MRI was computed. All imaging modalities detected the primary PCa in 18/19 patients, with68Ga-DOTA-RM2 PET not detecting any lesion in 1/19 patients. In the remaining patients,68Ga-PSMA and MRI were concordant. Seven patients presented seminal vesicles involvement on MRI, with two of these being also detected by68Ga-PSMA, and68Ga-DOTA-RM2 PET being negative. Regarding extraprostatic disease,68Ga-PSMA PET,68Ga-DOTA-RM2 PET and MRI resulted positive in seven, four and five patients at lymph-nodal level, respectively, and at a bone level in three, zero and one patients, respectively. These preliminary results suggest the potential complementary role of68Ga-PSMA PET,68Ga-DOTA-RM2 PET and MRI in PCa characterization during the staging phase.

Published
2021

21. Radiomics in pancreatic neuroendocrine tumors: methodological issues and clinical significance

Author

Bezzi, C, Mapelli, P, Presotto, L, Neri, I, Scifo, P, Savi, A, Bettinardi, V, Partelli, S, Gianolli, L, Falconi, M, Picchio, M, Bezzi C., Mapelli P., Presotto L., Neri I., Scifo P., Savi A., Bettinardi V., Partelli S., Gianolli L., Falconi M., Picchio M., Bezzi, C, Mapelli, P, Presotto, L, Neri, I, Scifo, P, Savi, A, Bettinardi, V, Partelli, S, Gianolli, L, Falconi, M, Picchio, M, Bezzi C., Mapelli P., Presotto L., Neri I., Scifo P., Savi A., Bettinardi V., Partelli S., Gianolli L., Falconi M., and Picchio M.

Abstract

Purpose: To present the state-of-art of radiomics in the context of pancreatic neuroendocrine tumors (PanNETs), with a focus on the methodological and technical approaches used, to support the search of guidelines for optimal applications. Furthermore, an up-to-date overview of the current clinical applications of radiomics in the field of PanNETs is provided. Methods: Original articles were searched on PubMed and Science Direct with specific keywords. Evaluations of the selected studies have been focused mainly on (i) the general radiomic workflow and the assessment of radiomic features robustness/reproducibility, as well as on the major clinical applications and investigations accomplished so far with radiomics in the field of PanNETs: (ii) grade prediction, (iii) differential diagnosis from other neoplasms, (iv) assessment of tumor behavior and aggressiveness, and (v) treatment response prediction. Results: Thirty-one articles involving PanNETs radiomic-related objectives were selected. In regard to the grade differentiation task, yielded AUCs are currently in the range of 0.7–0.9. For differential diagnosis, the majority of studies are still focused on the preliminary identification of discriminative radiomic features. Limited information is known on the prediction of tumors aggressiveness and of treatment response. Conclusions: Radiomics is recently expanding in the setting of PanNETs. From the analysis of the published data, it is emerging how, prior to clinical application, further validations are necessary and methodological implementations require optimization. Nevertheless, this new discipline might have the potential in assisting the current urgent need of improving the management strategies in PanNETs patients.

Published
2021

22. 99M-technetium-psma radio-guided surgery to detect nodal metastases in prostate cancer patients undergoing radical prostatectomy and extended pelvic lymph node dissection: a phase 2 prospective, single-institution study

Author

Gandaglia, G., primary, Mazzone, E., additional, Pellegrino, A., additional, Fossati, N., additional, Stabile, A., additional, Scuderi, S., additional, Barletta, F., additional, Leni, R., additional, Robesti, D., additional, D’Ambrosio, L., additional, Vitale, L.M., additional, Gajate, A.M. Samanes, additional, Picchio, M., additional, Gianolli, L., additional, Montorsi, F., additional, and Briganti, A., additional

Published
2022
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25. MO-0553 ENRT+ PET-guided SIB for prostate cancer lymph nodal relapses: long-term outcomes

Author

Fodor, A., primary, Deantoni, C.L., additional, Fiorino, C., additional, Cozzarini, C., additional, Dell'Oca, I., additional, Mangili, P., additional, Tummineri, R., additional, Zerbetto, F., additional, Sanchez Galvan, A., additional, Mandurino, G., additional, Villa, S.L., additional, Baroni, S., additional, Saddi, J., additional, Pacifico, P., additional, Perna, L., additional, Broggi, S., additional, Del Vecchio, A., additional, Picchio, M., additional, Gianolli, L., additional, and Di Muzio, N., additional

Published
2022
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26. Decoding the Heterogeneity of Malignant Gliomas by PET and MRI for Spatial Habitat Analysis of Hypoxia, Perfusion, and Diffusion Imaging: A Preliminary Study

Author

Bailo, M, Pecco, N, Callea, M, Scifo, P, Gagliardi, F, Presotto, L, Bettinardi, V, Fallanca, F, Mapelli, P, Gianolli, L, Doglioni, C, Anzalone, N, Picchio, M, Mortini, P, Falini, A, Castellano, A, Bailo, Michele, Pecco, Nicolò, Callea, Marcella, Scifo, Paola, Gagliardi, Filippo, Presotto, Luca, Bettinardi, Valentino, Fallanca, Federico, Mapelli, Paola, Gianolli, Luigi, Doglioni, Claudio, Anzalone, Nicoletta, Picchio, Maria, Mortini, Pietro, Falini, Andrea, Castellano, Antonella, Bailo, M, Pecco, N, Callea, M, Scifo, P, Gagliardi, F, Presotto, L, Bettinardi, V, Fallanca, F, Mapelli, P, Gianolli, L, Doglioni, C, Anzalone, N, Picchio, M, Mortini, P, Falini, A, Castellano, A, Bailo, Michele, Pecco, Nicolò, Callea, Marcella, Scifo, Paola, Gagliardi, Filippo, Presotto, Luca, Bettinardi, Valentino, Fallanca, Federico, Mapelli, Paola, Gianolli, Luigi, Doglioni, Claudio, Anzalone, Nicoletta, Picchio, Maria, Mortini, Pietro, Falini, Andrea, and Castellano, Antonella

Abstract

Background: Tumor heterogeneity poses major clinical challenges in high-grade gliomas (HGGs). Quantitative radiomic analysis with spatial tumor habitat clustering represents an innovative, non-invasive approach to represent and quantify tumor microenvironment heterogeneity. To date, habitat imaging has been applied mainly on conventional magnetic resonance imaging (MRI), although virtually extendible to any imaging modality, including advanced MRI techniques such as perfusion and diffusion MRI as well as positron emission tomography (PET) imaging. Objectives: This study aims to evaluate an innovative PET and MRI approach for assessing hypoxia, perfusion, and tissue diffusion in HGGs and derive a combined map for clustering of intra-tumor heterogeneity. Materials and Methods: Seventeen patients harboring HGGs underwent a pre-operative acquisition of MR perfusion (PWI), Diffusion (dMRI) and 18F-labeled fluoroazomycinarabinoside (18F-FAZA) PET imaging to evaluate tumor vascularization, cellularity, and hypoxia, respectively. Tumor volumes were segmented on fluid-attenuated inversion recovery (FLAIR) and T1 post-contrast images, and voxel-wise clustering of each quantitative imaging map identified eight combined PET and physiologic MRI habitats. Habitats’ spatial distribution, quantitative features and histopathological characteristics were analyzed. Results: A highly reproducible distribution pattern of the clusters was observed among different cases, particularly with respect to morphological landmarks as the necrotic core, contrast-enhancing vital tumor, and peritumoral infiltration and edema, providing valuable supplementary information to conventional imaging. A preliminary analysis, performed on stereotactic bioptic samples where exact intracranial coordinates were available, identified a reliable correlation between the expected microenvironment of the different spatial habitats and the actual histopathological features. A trend toward a higher representation of

Published
2022

27. Evaluation of a 2D UNet-Based Attenuation Correction Methodology for PET/MR Brain Studies

Author

Presotto, L, Bettinardi, V, Bagnalasta, M, Scifo, P, Savi, A, Vanoli, E, Fallanca, F, Picchio, M, Perani, D, Gianolli, L, De Bernardi, E, Presotto, Luca, Bettinardi, Valentino, Bagnalasta, Matteo, Scifo, Paola, Savi, Annarita, Vanoli, Emilia Giovanna, Fallanca, Federico, Picchio, Maria, Perani, Daniela, Gianolli, Luigi, De Bernardi, Elisabetta, Presotto, L, Bettinardi, V, Bagnalasta, M, Scifo, P, Savi, A, Vanoli, E, Fallanca, F, Picchio, M, Perani, D, Gianolli, L, De Bernardi, E, Presotto, Luca, Bettinardi, Valentino, Bagnalasta, Matteo, Scifo, Paola, Savi, Annarita, Vanoli, Emilia Giovanna, Fallanca, Federico, Picchio, Maria, Perani, Daniela, Gianolli, Luigi, and De Bernardi, Elisabetta

Abstract

Deep learning (DL) strategies applied to magnetic resonance (MR) images in positron emission tomography (PET)/MR can provide synthetic attenuation correction (AC) maps, and consequently PET images, more accurate than segmentation or atlas-registration strategies. As first objective, we aim to investigate the best MR image to be used and the best point of the AC pipeline to insert the synthetic map in. Sixteen patients underwent a 18F-fluorodeoxyglucose (FDG) PET/computed tomography (CT) and a PET/MR brain study in the same day. PET/CT images were reconstructed with attenuation maps obtained: (1) from CT (reference), (2) from MR with an atlas-based and a segmentation-based method and (3) with a 2D UNet trained on MR image/attenuation map pairs. As for MR, T1-weighted and Zero Time Echo (ZTE) images were considered; as for attenuation maps, CTs and 511 keV low-resolution attenuation maps were assessed. As second objective, we assessed the ability of DL strategies to provide proper AC maps in presence of cranial anatomy alterations due to surgery. Three 11C-methionine (METH) PET/MR studies were considered. PET images were reconstructed with attenuation maps obtained: (1) from diagnostic coregistered CT (reference), (2) from MR with an atlas-based and a segmentation-based method and (3) with 2D UNets trained on the sixteen FDG anatomically normal patients. Only UNets taking ZTE images in input were considered. FDG and METH PET images were quantitatively evaluated. As for anatomically normal FDG patients, UNet AC models generally provide an uptake estimate with lower bias than atlas-based or segmentation-based methods. The intersubject average bias on images corrected with UNet AC maps is always smaller than 1.5%, except for AC maps generated on too coarse grids. The intersubject bias variability is the lowest (always lower than 2%) for UNet AC maps coming from ZTE images, larger for other methods. UNet models working on MR ZTE images and generating synthetic CT or 511 k

Published
2022

28. 179: EARLY PREDICTION OF PATHOLOGICAL RESPONSE TO NEOADJUVANT CHEMORADIOTHERAPY FOR OESOPHAGEAL CANCER USING FULLY HYBRID PET/MR: PRELIMINARY RESULTS

Author

Palumbo, D, primary, Fiorino, C, additional, Mori, M, additional, Picchio, M, additional, Cossu, A, additional, Slim, N, additional, Puccetti, F, additional, Mazza, E, additional, Steidler, S, additional, Di Muzio, N, additional, Cascinu, S, additional, Gianolli, L, additional, Rosati, R, additional, and De Cobelli, F, additional

Published
2022
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30. Dual tracer 68Ga-DOTATOC and 18F-FDG PET/computed tomography radiomics in pancreatic neuroendocrine neoplasms: An endearing tool for preoperative risk assessment

Author

Mapelli, P, Partelli, S, Salgarello, M, Doraku, J, Pasetto, S, Rancoita, P, Muffatti, F, Bettinardi, V, Presotto, L, Andreasi, V, Gianolli, L, Picchio, M, Falconi, M, Mapelli P., Partelli S., Salgarello M., Doraku J., Pasetto S., Rancoita P. M. V., Muffatti F., Bettinardi V., Presotto L., Andreasi V., Gianolli L., Picchio M., Falconi M., Mapelli, P, Partelli, S, Salgarello, M, Doraku, J, Pasetto, S, Rancoita, P, Muffatti, F, Bettinardi, V, Presotto, L, Andreasi, V, Gianolli, L, Picchio, M, Falconi, M, Mapelli P., Partelli S., Salgarello M., Doraku J., Pasetto S., Rancoita P. M. V., Muffatti F., Bettinardi V., Presotto L., Andreasi V., Gianolli L., Picchio M., and Falconi M.

Abstract

Aim To explore the potentiality of radiomics analysis, performed on 68Ga-DOTATOC and fluorine-18-fluorodeoxyglucose (18F-FDG) PET/computed tomography (CT) images, in predicting tumour aggressiveness and outcome in patients candidate to surgery for pancreatic neuroendocrine neoplasms (PanNENs). Patients and methods Retrospective study including 61 patients who underwent 68Ga-DOTATOC and 18F-FDG PET/CT before surgery for PanNEN. Semiquantitative variables [SUVmax and somatostatin receptor density (SRD) for 68Ga-DOTATOC PET; SUVmax and MTV for 18F-FDG PET] and texture features [intensity variability, size zone variability (SZV), zone percentage, entropy; homogeneity, dissimilarity and coefficient of variation (Co-V)] have been analysed to evaluate their possible role in predicting tumour characteristics. Principal component analysis (PCA) was firstly performed and then multiple regression analyses were performed by using the extracted principal components. Results Regarding 68Ga-DOTATOC PET, SZV, entropy, intensity variability and SRD were predictive for tumour dimension. Regarding 18F-FDG PET, intensity variability, SZV, homogeneity, SUVmax and MTV were predictive for tumour dimension. Four principal components were extracted from PCA: PC1 correlated with all 18F-FDG variables, while PC2, PC3 and PC4 with 68Ga-DOTATOC variables. PC1 was the only significantly predicting angioinvasion (P = 0.0222); PC4 was the only one significantly predicting lymph nodal involvement (P = 0.0151). All principal components except PC4 significantly predicted tumour dimension (P <0.0001 for PC1, P = 0.0016 for PC2 and P < 0.0001 for PC3). Co-V from 68Ga-DOTATOC PET/CT was predictive of the outcome. Conclusion Specific texture features derived from preoperative 68Ga-DOTATOC and 18F-FDG PET/CT could noninvasively predict specific tumour characteristics and patients' outcome, delineating the potential role of dual tracer technique and texture analysis in the risk assessment of patients

Published
2020

31. Training and validation of a robust PET radiomic-based index predicting distant-relapse-free-survival after radiochemotherapy of patients with locally advanced pancreatic cancer

Author

Mori, M., primary, Passoni, P., additional, Incerti, E., additional, Broggi, S., additional, Reni, M., additional, Whybra, P., additional, Spezi, E., additional, Slim, N., additional, Vanoli, E.G., additional, Bettinardi, V., additional, Gianolli, L., additional, Picchio, M., additional, Di Muzio, N.G., additional, and Fiorino, C., additional

Published
2021
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34. Worldwide Variation in the Use of Nuclear Cardiology Camera Technology, Reconstruction Software, and Imaging Protocols

Author

Hirschfeld, Cole B., primary, Mercuri, Mathew, additional, Pascual, Thomas N.B., additional, Karthikeyan, Ganesan, additional, Vitola, João V., additional, Mahmarian, John J., additional, Better, Nathan, additional, Bouyoucef, Salah E., additional, Hee-Seung Bom, Henry, additional, Lele, Vikram, additional, Magboo, V. Peter C., additional, Alexánderson, Erick, additional, Allam, Adel H., additional, Al-Mallah, Mouaz H., additional, Dorbala, Sharmila, additional, Flotats, Albert, additional, Jerome, Scott, additional, Kaufmann, Philipp A., additional, Luxenburg, Osnat, additional, Shaw, Leslee J., additional, Underwood, S. Richard, additional, Rehani, Madan M., additional, Paez, Diana, additional, Dondi, Maurizio, additional, Einstein, Andrew J., additional, Einstein, A.J., additional, Pascual, T.N.B., additional, Paez, D., additional, Dondi, M., additional, Better, N., additional, Bouyoucef, S.E., additional, Karthikeyan, G., additional, Kashyap, R., additional, Lele, V., additional, Magboo, V.P.C., additional, Mahmarian, J.J., additional, Meeks, J.B., additional, Mercuri, M., additional, Mut, F., additional, Rehani, M.M., additional, Vitola, J.V., additional, Alexanderson, E., additional, Allam, A., additional, Al-Mallah, M.H., additional, Bom, H., additional, Flotats, A., additional, Jerome, S., additional, Kaufmann, P.A., additional, Luxenburg, O., additional, Mahmarian, J., additional, Shaw, L.J., additional, Underwood, S.R., additional, Vitola, J., additional, Amouri, W., additional, Essabbah, H., additional, Gassama, S.S., additional, Makhdomi, K.B., additional, El Mustapha, G.I.E., additional, El Ouchdi, N., additional, Qaïs, N., additional, Soni, N., additional, Vangu, W., additional, Abazid, R.M., additional, Adams, B., additional, Agarwal, V., additional, Alfeeli, M.A., additional, Alnafisi, N., additional, Bernabe, L., additional, Bural, G.G., additional, Chaiwatanarat, T., additional, Chandraguptha, J.M., additional, Cheon, G.J., additional, Cho, I., additional, Dogan, A.S., additional, Eftekhari, M., additional, Frenkel, A., additional, Garty, I., additional, George, S., additional, Geramifar, P., additional, Golan, H., additional, Habib, S., additional, Hussain, R., additional, Im, H., additional, Jeon, H.-J., additional, Kalawat, T., additional, Kang, W.J., additional, Keng, F., additional, Klaipetch, A., additional, Kumar, P.G., additional, Lee, J., additional, Lee, W.W., additional, Lim, I., additional, Macaisa, C.M.M., additional, Malhotra, G., additional, Mittal, B.R., additional, Mohammad, M.H., additional, Mohan, P., additional, Mulyanto, I.D., additional, Nariman, D., additional, Nayak, U.N., additional, Niaz, K., additional, Nikolov, G., additional, Obaldo, J.M., additional, Ozturk, E., additional, Park, J.M., additional, Park, S., additional, Patel, C.D., additional, Phuong, H.K., additional, Quinon, A.P., additional, Rajini, T.R., additional, Saengsuda, Y., additional, Santiago, J., additional, Sayman, H.B., additional, Shinto, A.S., additional, Sivasubramaniyan, V., additional, Son, M.H., additional, Sudhakar, P., additional, Syed, G.M.S., additional, Tamaki, N., additional, Thamnirat, K., additional, Thientunyakit, T., additional, Thongmak, S., additional, Velasco, D.N., additional, Verma, A., additional, Vutrapongwatana, U., additional, Wang, Y., additional, Won, K.S., additional, Yao, Z., additional, Yingsa-nga, T., additional, Yudistiro, R., additional, Yue, K.T., additional, Zafrir, N., additional, Adrian, S.C., additional, Agostini, D., additional, Aguadé, S., additional, Armitage, G., additional, Backlund, M., additional, Backman, M., additional, Baker, M., additional, Balducci, M.T., additional, Bavelaar, C., additional, Berovic, M., additional, Bertagna, F., additional, Beuchel, R., additional, Biggi, A., additional, Bisi, G., additional, Bonini, R., additional, Bradley, A., additional, Brudin, L., additional, Bruno, I., additional, Busnardo, E., additional, Casoni, R., additional, Choudhri, A., additional, Cittanti, C., additional, Clauss, R., additional, Costa, D.C., additional, Costa, M., additional, Dixon, K., additional, Dziuk, M., additional, Egelic, N., additional, Eriksson, I., additional, Fagioli, G., additional, de Faria, D.B., additional, Florimonte, L., additional, Francini, A., additional, French, M., additional, Gallagher, E., additional, Garai, I., additional, Geatti, O., additional, Genovesi, D., additional, Gianolli, L., additional, Gimelli, A., additional, Giudice, E. del, additional, Halliwell, S., additional, Hansson, M.J., additional, Harrison, C., additional, Homans, F., additional, Horton, F., additional, Jędrzejuk, D., additional, Jogi, J., additional, Johansen, A., additional, Johansson, H., additional, Kalnina, M., additional, Kaminek, M., additional, Kiss, A., additional, Kobylecka, M., additional, Kostkiewicz, M., additional, Kropp, J., additional, Kullenberg, R., additional, Lahoutte, T., additional, Lang, O., additional, Larsson, Y.H., additional, Lázár, M., additional, Leccisotti, L., additional, Leners, N., additional, Lindner, O., additional, Lipp, R.W., additional, Maenhout, A., additional, Maffioli, L., additional, Marcassa, C., additional, Martins, B., additional, Marzullo, P., additional, Medolago, G., additional, Mendiguchía, C.G., additional, Mirzaei, S., additional, Mori, M., additional, Nardi, B., additional, Nazarenko, S., additional, Nikoletic, K., additional, Oleksa, R., additional, Parviainen, T., additional, Patrina, J., additional, Peace, R., additional, Pirich, C., additional, Piwowarska-Bilska, H., additional, Popa, S., additional, Prakash, V., additional, Pubul, V., additional, Puklavec, L., additional, Rac, S., additional, Ratniece, M., additional, Rogan, S.A., additional, Romeo, A., additional, Rossi, M., additional, Ruiz, D., additional, Sabharwal, N., additional, Salobir, B.G., additional, Santos, A.I., additional, Saranovic, S., additional, Sarkozi, A., additional, Schneider, R.P., additional, Sciagra, R., additional, Scotti, S., additional, Servini, Z., additional, Setti, L.R., additional, Starck, S.-Å., additional, Vajauskas, D., additional, Veselý, J., additional, Vieni, A., additional, Vignati, A., additional, Vito, I.M., additional, Weiss, K., additional, Wild, D., additional, Zdraveska-Kochovska, M., additional, Agüro, R.N., additional, Alvarado, N., additional, Barral, C.M., additional, Beretta, M., additional, Berrocal, I., additional, Cuellar, J.F. Batista, additional, Cabral Chang, T.-M., additional, Cabrera Rodríguez, L.O., additional, Canessa, J., additional, Castro Mora, G., additional, Claudia, A.C., additional, Clavelo, G.F., additional, Júnior, A.F. Cruz, additional, Faccio, F.F., additional, Fernández, K.M., additional, Garibo, J.R. Gomez, additional, Gonzalez, U., additional, González E, P., additional, Guzzo, M.A., additional, Jofre, J., additional, Kapitán, M., additional, Kempfer, G., additional, Lopez, J.L., additional, Massardo V, T., additional, Medeiros Colaco, I., additional, Mesquita, C.T., additional, Montecinos, M., additional, Neubauer, S., additional, Pabon, L.M., additional, Puente, A., additional, Rochela Vazquez, L.M., additional, Serna Macias, J.A., additional, Silva Pino, A.G., additional, Huber, F.Z. Tártari, additional, Tovar, A.P., additional, Vargas, L., additional, Wiefels, C., additional, Aljizeeri, A., additional, Alvarez, R.J., additional, Barger, D., additional, Beardwood, W., additional, Behrens, J., additional, Brann, L., additional, Brown, D., additional, Carr, H., additional, Churchwell, K., additional, Comingore, G.A., additional, Corbett, J., additional, Costello, M., additional, Cruz, F., additional, Depinet, T., additional, Dorbala, S., additional, Earles, M., additional, Esteves, F.P., additional, Etherton, E., additional, Fanning, R.J., additional, Fornace, J., additional, Franks, L., additional, Gewirtz, H., additional, Gulanchyn, K., additional, Hannah, C.-L., additional, Hays, J., additional, Hendrickson, J., additional, Hester, J., additional, Holmes, K., additional, Johnson, A., additional, Jopek, C., additional, Lewin, H., additional, Lyons, J., additional, Manley, C., additional, Meden, J., additional, Moore, S., additional, Moore, W.H., additional, Murthy, V., additional, Nace, R., additional, Neely, D., additional, Nelson, L., additional, Niedermaier, O., additional, Rice, D., additional, Rigs, R., additional, Schiffer, K., additional, Schockling, E., additional, Schultz, T., additional, Schumacker, T., additional, Sheesley, B., additional, Sheikh, A., additional, Siegel, B., additional, Slim, A.M., additional, Smith, J., additional, Szulc, M., additional, Tanskersley, N., additional, Tilkemeier, P., additional, Valdez, G.D., additional, Vrooman, R., additional, Wawrowicz, D., additional, Winchester, D.E., additional, Alcheikh, A., additional, Allen, B., additional, Atkins, E., additional, Bevan, J., additional, Bonomini, C., additional, Christiansen, J., additional, Clack, L., additional, Craig, E., additional, Dixson, H., additional, Duncan, I., additional, Fredericks, S., additional, Gales, S., additional, Hampson, R., additional, Hanley, T., additional, Hartcher, K., additional, Hassall, J., additional, Kelley, B., additional, Kelly, S., additional, Kidd, T., additional, de Kort, T., additional, Larcos, G., additional, Macdonald, W., additional, McGrath, C., additional, Murdoch, E., additional, O'Malley, S., additional, O'Rourke, M., additional, Pack, M., additional, Pearce, R., additional, Praehofer, R., additional, Ramsay, S., additional, Scarlett, L., additional, Smidt, K., additional, Souvannavong, F., additional, Taubman, K., additional, Taylor, G., additional, Tse, K., additional, Unger, S., additional, and Weale, J., additional

Published
2021
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38. US/TOF-PET endorectal probe compatible with MR, for diagnosis and staging of the prostate cancer

Author

Garibaldi, F., Bettinardi, V., Brembilla, G., Briganti, A., Cisbani, E., Clinthorne, N., Cobelli, F. de, Taille, C. de la, Fournelle, M., Gianolli, L., Majewski, S., Montorsi, F., Nuyts, J., Picchio, M., Ziemons, K., Organisation de Micro-Électronique Générale Avancée (OMEGA), École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Garibaldi, F., Bettinardi, V., Brembilla, G., Briganti, A., Cisbani, E., Clinthorne, N., de Cobelli, F., de la Taille, C., Fournelle, M., Gianolli, L., Majewski, S., Montorsi, F., Nuyts, J., Picchio, M., Ziemons, K., and Publica

Subjects
Science & Technology, Physics, ACCURACY, Physics, Multidisciplinary, TOF-PET, COIL, prostate cancer, ATTENUATION, DESIGN, endorectal probe, Physical Sciences, MULTIPARAMETRIC MRI, SIMULTANEOUS PET/MRI, BIOPSY, RECONSTRUCTION, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], ULTRASOUND
Abstract

International audience; Prostate Cancer (PCa) is one of the most prevalent cancers worldwide. Early and accurate diagnosis of PCa is crucial for effective and successful treatment. Our project aims at developing a unique, highly performing flexible geometry multi-modality imaging system for diagnosis and staging of PCa. The imager will have the form of an endorectal probe combining high-resolution (0.1 mm) ultrasound (US) with a very high-resolution Positron Emission Tomography (PET) probe (1 mm spatial resolution) with exceptional Time-of-Flight (TOF) capability (100 ps FWHM targeted) compatible with Magnetic Resonance Imaging (MRI), in coincidence with a set of external PET panels. While standard multiparametric MRI (mpMR) has drawbacks, diagnosis will be improved significantly by the introduction of PSPMA-PET as well as the simultaneous PET/MR imaging. The system will be capable of morphological visualization instantly and continuously combined with biological and metabolic activity, offering crucial improvement with respect to standard systems (detection of ∼ 2 mm lesions vs. ∼ 6 mm lesions) in spatial resolution, efficiency, signal-to-noise ratio (SNR), scanning time and/or lowering injected dose.

Published
2019
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39. Worldwide Diagnostic Reference Levels for Single-Photon Emission Computed Tomography Myocardial Perfusion Imaging: Findings From INCAPS

Author

Hirschfeld, C. B., Dondi, M., Pascual, T. N. B., Mercuri, M., Vitola, J., Karthikeyan, G., Better, N., Mahmarian, J. J., Bouyoucef, S. E., Hee-Seung Bom, H., Lele, V., Magboo, V. P. C., Alexanderson, E., Allam, A. H., Al-Mallah, M. H., Flotats, A., Jerome, S., Kaufmann, P. A., Luxenburg, O., Underwood, S. R., Rehani, M. M., Vassileva, J., Paez, D., Einstein, A. J., Kashyap, R., Meeks, J. B., Mut, F., Vitola, J. V., Allam, A., Bom, H., Mahmarian, J., Shaw, L. J., Amouri, W., Essabbah, H., Gassama, S. S., Makhdomi, K. B., El Mustapha, G. I. E., El Ouchdi, N., Qais, N., Soni, N., Vangu, W., Abazid, R. M., Adams, B., Agarwal, V., Alfeeli, M. A., Alnafisi, N., Bernabe, L., Bural, G. G., Chaiwatanarat, T., Chandraguptha, J. M., Cheon, G. J., Cho, I., Dogan, A. S., Eftekhari, M., Frenkel, A., Garty, I., George, S., Geramifar, P., Golan, H., Habib, S., Hussain, R., Im, H., Jeon, H. -J., Kalawat, T., Kang, W. J., Keng, F., Klaipetch, A., Kumar, P. G., Lee, J., Lee, W. W., Lim, I., Macaisa, C. M. M., Malhotra, G., Mittal, B. R., Mohammad, M. H., Mohan, P., Mulyanto, I. D., Nariman, D., Nayak, U. N., Niaz, K., Nikolov, G., Obaldo, J. M., Ozturk, E., Park, J. M., Park, S., Patel, C. D., Phuong, H. K., Quinon, A. P., Rajini, T. R., Saengsuda, Y., Santiago, J., Sayman, H. B., Shinto, A. S., Sivasubramaniyan, V., Son, M. H., Sudhakar, P., Syed, G. M. S., Tamaki, N., Thamnirat, K., Thientunyakit, T., Thongmak, S., Velasco, D. N., Verma, A., Vutrapongwatana, U., Wang, Y., Won, K. S., Yao, Z., Yingsa-nga, T., Yudistiro, R., Yue, K. T., Zafrir, N., Adrian, S. C., Agostini, D., Aguade, S., Armitage, G., Backlund, M., Backman, M., Baker, M., Balducci, M. T., Bavelaar, C., Berovic, M., Bertagna, F., Beuchel, R., Biggi, A., Bisi, G., Bonini, R., Bradley, A., Brudin, L., Bruno, I., Busnardo, E., Casoni, R., Choudhri, A., Cittanti, C., Clauss, R., Costa, D. C., Costa, M., Dixon, K., Dziuk, M., Egelic, N., Eriksson, I., Fagioli, G., de Faria, D. B., Florimonte, L., Francini, A., French, M., Gallagher, E., Garai, I., Geatti, O., Genovesi, D., Gianolli, L., Gimelli, A., del Giudice, E., Halliwell, S., Hansson, M. J., Harrison, C., Homans, F., Horton, F., Jedrzejuk, D., Jogi, J., Johansen, A., Johansson, H., Kalnina, M., Kaminek, M., Kiss, A., Kobylecka, M., Kostkiewicz, M., Kropp, J., Kullenberg, R., Lahoutte, T., Lang, O., Larsson, Y. H., Lazar, M., Leccisotti, L., Leners, N., Lindner, O., Lipp, R. W., Maenhout, A., Maffioli, L., Marcassa, C., Martins, B., Marzullo, P., Medolago, G., Mendiguchia, C. G., Mirzaei, S., Mori, M., Nardi, B., Nazarenko, S., Nikoletic, K., Oleksa, R., Parviainen, T., Patrina, J., Peace, R., Pirich, C., Piwowarska-Bilska, H., Popa, S., Prakash, V., Pubul, V., Puklavec, L., Rac, S., Ratniece, M., Rogan, S. A., Romeo, A., Rossi, M., Ruiz, D., Sabharwal, N., Salobir, B. G., Santos, A. I., Saranovic, S., Sarkozi, A., Schneider, R. P., Sciagra, R., Scotti, S., Servini, Z., Setti, L. R., Starck, S. -A., Vajauskas, D., Vesely, J., Vieni, A., Vignati, A., Vito, I. M., Weiss, K., Wild, D., Zdraveska-Kochovska, M., Aguro, R. N., Alvarado, N., Barral, C. M., Beretta, M., Berrocal, I., Cuellar, J. F. B., Chang, T. -M. C., Rodriguez, L. O. C., Canessa, J., Mora, G. C., AGABITI-ROSEI, Claudia, Clavelo, G. F., Junior, A. F. C., Faccio, F. F., Fernandez, K. M., Garibo, J. R. G., Gonzalez, U., Gonzalez E, P., Guzzo, M. A., Jofre, J., Kapitan, M., Kempfer, G., Lopez, J. L., Massardo V, T., Colaco, I. M., Mesquita, C. T., Montecinos, M., Neubauer, S., Pabon, L. M., Puente, A., Vazquez, L. M. R., Macias, J. A. S., Pino, A. G. S., Huber, F. Z. T., Tovar, A. P., Vargas, L., Wiefels, C., Aljizeeri, A., Alvarez, R. J., Barger, D., Beardwood, W., Behrens, J., Brann, L., Brown, D., Carr, H., Churchwell, K., Comingore, G. A., Corbett, J., Costello, M., Cruz, F., Depinet, T., Dorbala, S., Earles, M., Esteves, F. P., Etherton, E., Fanning, R. J., Fornace, J., Franks, L., Gewirtz, H., Gulanchyn, K., Hannah, C. -L., Hays, J., Hendrickson, J., Hester, J., Holmes, K., Johnson, A., Jopek, C., Lewin, H., Lyons, J., Manley, C., Meden, J., Moore, S., Moore, W. H., Murthy, V., Nace, R., Neely, D., Nelson, L., Niedermaier, O., Rice, D., Rigs, R., Schiffer, K., Schockling, E., Schultz, T., Schumacker, T., Sheesley, B., Sheikh, A., Siegel, B., Slim, A. M., Smith, J., Szulc, M., Tanskersley, N., Tilkemeier, P., Valdez, G. D., Vrooman, R., Wawrowicz, D., Winchester, D. E., Alcheikh, A., Allen, B., Atkins, E., Bevan, J., Bonomini, C., Christiansen, J., Clack, L., Craig, E., Dixson, H., Duncan, I., Fredericks, S., Gales, S., Hampson, R., Hanley, T., Hartcher, K., Hassall, J., Kelley, B., Kelly, S., Kidd, T., de Kort, T., Larcos, G., Macdonald, W., Mcgrath, C., Murdoch, E., O'Malley, S., O'Rourke, M., Pack, M., Pearce, R., Praehofer, R., Ramsay, S., Scarlett, L., Smidt, K., Souvannavong, F., Taubman, K., Taylor, G., Tse, K., Unger, S., and Weale, J.

Subjects
administered activity, diagnostic reference level, radiation dose reduction, SPECT myocardial perfusion imaging, NO
Published
2021

40. Impact of age on the selection of nuclear cardiology stress protocols: The INCAPS (IAEA nuclear cardiology protocols) study

Author

Al-Mallah, Mh, Pascual, Tnb, Mercuri, M, Vitola, Jv, Karthikeyan, G, Better, N, Dondi, M, Paez, D, Eistein, Aj, Bouyoucef, Se, Allam, Ah, Vangu, M, Rehani, Mm, Kashyap, R, Lele, V, Magboo, Vpc, Mahmarian, Jj, Mut, F, Alexánderson, E, Allam, A, Bom, H, Flotats, A, Jerome, S, Kaufmann, Pa, Luxenburg, O, Mahmarian, J, Shaw, Lj, Underwood, Sr, Amouri, W, Essabbah, H, Gassama, Ss, Makhdomi, Kb, El Mustapha, Gie, El Ouchdi, N, Qaïs, N, Soni, N, Vangu, W, Abazid, Rm, Adams, B, Agarwal, V, Alfeeli, Ma, Alnafisi, N, Bernabe, L, Bural, Gg, Chaiwatanarat, T, Chandraguptha, Jm, Cheon, Gj, Cho, I, Dogan, As, Eftekhari, M, Frenkel, A, Garty, I, George, S, Geramifar, P, Golan, H, Habib, S, Hussain, R, Im, H, Jeon, H-J, Kalawat, T, Kang, Wj, Keng, F, Klaipetch, A, Kumar, Pg, Lee, J, Lee, Ww, Lim, I, Macaisa, Cmm, Malhotra, G, Mittal, Br, Mohammad, Mh, Mohan, P, Mulyanto, Id, Nariman, D, Nayak, Un, Niaz, K, Nikolov, G, Obaldo, Jm, Ozturk, E, Park, Jm, Park, S, Patel, Cd, Phuong, Hk, Quinon, Ap, Rajini, Tr, Saengsuda, Y, Santiago, J, Sayman, Hb, Shinto, As, Sivasubramaniyan, V, Son, Mh, Sudhakar, P, Syed, Gms, Tamaki, N, Thamnirat, K, Thientunyakit, T, Thongmak, S, Velasco, Dn, Verma, A, Vutrapongwatana, U, Wang, Y, Won, Ks, Yao, Z, Yingsa-Nga, T, Yudistiro, R, Yue, Kt, Zafrir, N, Adrian, Sc, Agostini, D, Aguadé, S, Armitage, G, Backlund, M, Backman, M, Baker, M, Balducci, Mt, Bavelaar, C, Berovic, M, Bertagna, F, Beuchel, R, Biggi, A, Bisi, G, Bonini, R, Bradley, A, Brudin, L, Bruno, I, Busnardo, E, Casoni, R, Choudhri, A, Cittanti, C, Clauss, R, Costa, Dc, Costa, M, Dixon, K, Dziuk, M, Egelic, N, Eriksson, I, Fagioli, G, De Faria, Db, Florimonte, L, Francini, Alberto, French, M, Gallagher, E, Garai, I, Geatti, O, Genovesi, D, Gianolli, L, Gimelli, A, Del Giudice, E, Halliwell, S, Hansson, Mj, Harrison, C, Homans, F, Horton, F, Jȩdrzejuk, D, Jogi, J, Johansen, A, Johansson, H, Kalnina, M, Kaminek, M, Kiss, A, Kobylecka, M, Kostkiewicz, M, Kropp, J, Kullenberg, R, Lahoutte, T, Lang, O, Larsson, Yh, Lázár, M, Leccisotti, L, Leners, N, Lindner, O, Lipp, Rw, Maenhout, A, Maffioli, L, Marcassa, C, Martins, B, Marzullo, P, Medolago, G, Mendiguchía, Cg, Mirzaei, S, Mori, M, Nardi, B, Nazarenko, S, Nikoletic, K, Oleksa, R, Parviainen, T, Patrina, J, Peace, R, Pirich, C, Piwowarska-Bilska, H, Popa, S, Prakash, V, Pubul, V, Puklavec, L, Rac, S, Ratniece, M, Rogan, Sa, Romeo, Annunziata, Rossi, M, Ruiz, D, Sabharwal, N, Salobir, Bg, Santos, Ai, Saranovic, S, Sarkozi, A, Schneider, Rp, Sciagra, R, Scotti, S, Servini, Z, Setti, Lr, Starck, S-A., Vajauskas, D, Veselý, J, Vieni, A, Vignati, A, Vito, I. M., Weiss, K, Wild, D, Zdraveska-Kochovska, M, Agüro, Rn, Alvarado, N, Barral, Cm, Beretta, M, Berrocal, I, Batista Cuellar, Jf, Cabral Chang, T-M, Cabrera Rodríguez, Lo, Canessa, J, Castro Mora, G, Claudia, Ac, Clavelo, Gf, Cruz, Af, Faccio, Ff, Fernández, Km, Gomez Garibo, Jr, Gonzalez, U, González, Pe, Guzzo, Ma, Jofre, J, Kapitán, M, Kempfer, G, Lopez, Jl, Massardo, Tv, Medeiros Colaco, I, Mesquita, Ct, Montecinos, M, Neubauer, S, Pabon, Lm, Puente, A, Rochela Vazquez, Lm, Serna Macias, Ja, Silva Pino, Ag, Tártari Huber, Fz, Tovar, Ap, Vargas, L, Wiefels, C, Aljizeeri, A, Alvarez, Rj, Barger, D, Beardwood, W, Behrens, J, Brann, L, Brown, D, Carr, H, Churchwell, K, Comingore, Ga, Corbett, J, Costello, M, Cruz, F, Depinet, T, Dorbala, S, Earles, M, Esteves, Fp, Etherton, E, Fanning, Rj, Fornace, J, Franks, L, Gewirtz, H, Gulanchyn, K, Hannah, C-L, Hays, J, Hendrickson, J, Hester, J, Holmes, K, Johnson, A, Jopek, C, Lewin, H, Lyons, J, Manley, C, Meden, J, Moore, S, Moore, Wh, Murthy, V, Nace, R, Neely, D, Nelson, L, Niedermaier, O, Rice, D, Rigs, R, Schiffer, K, Schockling, E, Schultz, T, Schumacker, T, Sheesley, B, Sheikh, A, Siegel, B, Slim, Am, Smith, J, Szulc, Mc, Tanskersley, N, Tilkemeier, P, Valdez, Gd, Vrooman, R, Wawrowicz, D, Winchester, De, Alcheikh, A, Allen, B, Atkins, E, Bevan, J, Bonomini, C, Christiansen, J, Clack, L, Craig, E, Dixson, H, Duncan, I, Fredericks, S, Gales, S, Hampson, R, Hanley, T, Hartcher, K, Hassall, J, Kelley, B, Kelly, S, Kidd, T, De Kort, T, Larcos, G, Macdonald, W, Mcgrath, C, Murdoch, E, O'Malley, S, O'Rourke, M, Pack, M, Pearce, R, Praehofer, R, Ramsay, S, Scarlett, L, Smidt, K, Souvannavong, F, Taubman, K, Taylor, G, Tse, K, Unger, S, and Weale, J

Subjects
Ionizing radiation, Male, medicine.medical_specialty, Cross-sectional study, Cardiology, Guidelines, 030204 cardiovascular system & hematology, Radiation Dosage, Effective dose (radiation), NO, Cohort Studies, 03 medical and health sciences, Myocardial perfusion imaging, Age, 0302 clinical medicine, Internal medicine, Humans, Medicine, 030212 general & internal medicine, Tomography, Age Factors, Aged, Cross-Sectional Studies, Female, Middle Aged, Myocardial Perfusion Imaging, Positron-Emission Tomography, Practice Guidelines as Topic, Radiation Exposure, Retrospective Studies, Tomography, Emission-Computed, Single-Photon, Nuclear Energy, medicine.diagnostic_test, business.industry, Retrospective cohort study, Radiation exposure, Cohort, Emission-Computed, Cardiology and Cardiovascular Medicine, business, Single-Photon, Cohort study
Abstract

There is growing concern about radiation exposure from nuclear myocardial perfusion imaging (MPI), particularly among younger patients who are more prone to develop untoward effects of ionizing radiation, and hence US and European professional society guidelines recommend age as a consideration in weighing radiation risk from MPI. We aimed to determine how patient radiation doses from MPI vary across age groups in a large contemporary international cohort.Data were collected as part of a global cross-sectional study of centers performing MPI coordinated by the International Atomic Energy Agency (IAEA). Sites provided information on each MPI study completed during a single week in March-April 2013. We compared across age groups laboratory adherence to pre-specified radiation-related best practices, radiation effective dose (ED; a whole-body measure reflecting the amount of radiation to each organ and its relative sensitivity to radiation's deleterious effects), and the proportion of patients with ED ≤ 9 mSv, a target level specified in guidelines.Among 7911 patients undergoing MPI in 308 laboratories in 65 countries, mean ED was 10.0 ± 4.5 mSv with slightly higher exposure among younger age groups (trend p value 0.001). There was no difference in the proportion of patients with ED ≤ 9 mSv across age groups, or in adherence to best practices based on the median age of patients in a laboratory.In contemporary nuclear cardiology practice, the age of the patient appears not to impact protocol selection and radiation dose, contrary to professional society guidelines.

Published
2018
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41. Worldwide Diagnostic Reference Levels for Single-Photon Emission Computed Tomography Myocardial Perfusion Imaging

Author

Hirschfeld, Cole B., primary, Dondi, Maurizio, additional, Pascual, Thomas N.B., additional, Mercuri, Mathew, additional, Vitola, Joao, additional, Karthikeyan, Ganesan, additional, Better, Nathan, additional, Mahmarian, John J., additional, Bouyoucef, Salah E., additional, Hee-Seung Bom, Henry, additional, Lele, Vikram, additional, Magboo, Vincent Peter C., additional, Alexánderson, Erick, additional, Allam, Adel H., additional, Al-Mallah, Mouaz H., additional, Flotats, Albert, additional, Jerome, Scott, additional, Kaufmann, Philipp A., additional, Luxenburg, Osnat, additional, Underwood, S. Richard, additional, Rehani, Madan M., additional, Vassileva, Jenia, additional, Paez, Diana, additional, Einstein, Andrew J., additional, Einstein, A.J., additional, Pascual, T.N.B., additional, Paez, D., additional, Dondi, M., additional, Better, N., additional, Bouyoucef, S.E., additional, Karthikeyan, G., additional, Kashyap, R., additional, Lele, V., additional, Magboo, V.P.C., additional, Mahmarian, J.J., additional, Meeks, J.B., additional, Mercuri, M., additional, Mut, F., additional, Rehani, M.M., additional, Vitola, J.V., additional, Alexanderson, E., additional, Allam, A., additional, Al-Mallah, M.H., additional, Bom, H., additional, Flotats, A., additional, Jerome, S., additional, Kaufmann, P.A., additional, Luxenburg, O., additional, Mahmarian, J., additional, Shaw, L.J., additional, Underwood, S.R., additional, Vitola, J., additional, Amouri, W., additional, Essabbah, H., additional, Gassama, S.S., additional, Makhdomi, K.B., additional, El Mustapha, G.I.E., additional, El Ouchdi, N., additional, Qaïs, N., additional, Soni, N., additional, Vangu, W., additional, Abazid, R.M., additional, Adams, B., additional, Agarwal, V., additional, Alfeeli, M.A., additional, Alnafisi, N., additional, Bernabe, L., additional, Bural, G.G., additional, Chaiwatanarat, T., additional, Chandraguptha, J.M., additional, Cheon, G.J., additional, Cho, I., additional, Dogan, A.S., additional, Eftekhari, M., additional, Frenkel, A., additional, Garty, I., additional, George, S., additional, Geramifar, P., additional, Golan, H., additional, Habib, S., additional, Hussain, R., additional, Im, H., additional, Jeon, H.-J., additional, Kalawat, T., additional, Kang, W.J., additional, Keng, F., additional, Klaipetch, A., additional, Kumar, P.G., additional, Lee, J., additional, Lee, W.W., additional, Lim, I., additional, Macaisa, C.M.M., additional, Malhotra, G., additional, Mittal, B.R., additional, Mohammad, M.H., additional, Mohan, P., additional, Mulyanto, I.D., additional, Nariman, D., additional, Nayak, U.N., additional, Niaz, K., additional, Nikolov, G., additional, Obaldo, J.M., additional, Ozturk, E., additional, Park, J.M., additional, Park, S., additional, Patel, C.D., additional, Phuong, H.K., additional, Quinon, A.P., additional, Rajini, T.R., additional, Saengsuda, Y., additional, Santiago, J., additional, Sayman, H.B., additional, Shinto, A.S., additional, Sivasubramaniyan, V., additional, Son, M.H., additional, Sudhakar, P., additional, Syed, G.M.S., additional, Tamaki, N., additional, Thamnirat, K., additional, Thientunyakit, T., additional, Thongmak, S., additional, Velasco, D.N., additional, Verma, A., additional, Vutrapongwatana, U., additional, Wang, Y., additional, Won, K.S., additional, Yao, Z., additional, Yingsa-nga, T., additional, Yudistiro, R., additional, Yue, K.T., additional, Zafrir, N., additional, Adrian, S.C., additional, Agostini, D., additional, Aguadé, S., additional, Armitage, G., additional, Backlund, M., additional, Backman, M., additional, Baker, M., additional, Balducci, M.T., additional, Bavelaar, C., additional, Berovic, M., additional, Bertagna, F., additional, Beuchel, R., additional, Biggi, A., additional, Bisi, G., additional, Bonini, R., additional, Bradley, A., additional, Brudin, L., additional, Bruno, I., additional, Busnardo, E., additional, Casoni, R., additional, Choudhri, A., additional, Cittanti, C., additional, Clauss, R., additional, Costa, D.C., additional, Costa, M., additional, Dixon, K., additional, Dziuk, M., additional, Egelic, N., additional, Eriksson, I., additional, Fagioli, G., additional, de Faria, D.B., additional, Florimonte, L., additional, Francini, A., additional, French, M., additional, Gallagher, E., additional, Garai, I., additional, Geatti, O., additional, Genovesi, D., additional, Gianolli, L., additional, Gimelli, A., additional, del Giudice, E., additional, Halliwell, S., additional, Hansson, M.J., additional, Harrison, C., additional, Homans, F., additional, Horton, F., additional, Jędrzejuk, D., additional, Jogi, J., additional, Johansen, A., additional, Johansson, H., additional, Kalnina, M., additional, Kaminek, M., additional, Kiss, A., additional, Kobylecka, M., additional, Kostkiewicz, M., additional, Kropp, J., additional, Kullenberg, R., additional, Lahoutte, T., additional, Lang, O., additional, Larsson, Y.H., additional, Lázár, M., additional, Leccisotti, L., additional, Leners, N., additional, Lindner, O., additional, Lipp, R.W., additional, Maenhout, A., additional, Maffioli, L., additional, Marcassa, C., additional, Martins, B., additional, Marzullo, P., additional, Medolago, G., additional, Mendiguchía, C.G., additional, Mirzaei, S., additional, Mori, M., additional, Nardi, B., additional, Nazarenko, S., additional, Nikoletic, K., additional, Oleksa, R., additional, Parviainen, T., additional, Patrina, J., additional, Peace, R., additional, Pirich, C., additional, Piwowarska-Bilska, H., additional, Popa, S., additional, Prakash, V., additional, Pubul, V., additional, Puklavec, L., additional, Rac, S., additional, Ratniece, M., additional, Rogan, S.A., additional, Romeo, A., additional, Rossi, M., additional, Ruiz, D., additional, Sabharwal, N., additional, Salobir, B.G., additional, Santos, A.I., additional, Saranovic, S., additional, Sarkozi, A., additional, Schneider, R.P., additional, Sciagra, R., additional, Scotti, S., additional, Servini, Z., additional, Setti, L.R., additional, Starck, S.-Å., additional, Vajauskas, D., additional, Veselý, J., additional, Vieni, A., additional, Vignati, A., additional, Vito, I.M., additional, Weiss, K., additional, Wild, D., additional, Zdraveska-Kochovska, M., additional, Agüro, R.N., additional, Alvarado, N., additional, Barral, C.M., additional, Beretta, M., additional, Berrocal, I., additional, Cuellar, J.F. Batista, additional, Chang, T-M. Cabral, additional, Rodríguez, L.O. Cabrera, additional, Canessa, J., additional, Mora, G. Castro, additional, Claudia, A.C., additional, Clavelo, G.F., additional, Júnior, A.F. Cruz, additional, Faccio, F.F., additional, Fernández, K.M., additional, Garibo, J.R. Gomez, additional, Gonzalez, U., additional, González E, P., additional, Guzzo, M.A., additional, Jofre, J., additional, Kapitán, M., additional, Kempfer, G., additional, Lopez, J.L., additional, Massardo V, T., additional, Colaco, I. Medeiros, additional, Mesquita, C.T., additional, Montecinos, M., additional, Neubauer, S., additional, Pabon, L.M., additional, Puente, A., additional, Vazquez, L.M. Rochela, additional, Macias, J.A. Serna, additional, Pino, A.G. Silva, additional, Huber, F.Z. Tártari, additional, Tovar, A.P., additional, Vargas, L., additional, Wiefels, C., additional, Aljizeeri, A., additional, Alvarez, R.J., additional, Barger, D., additional, Beardwood, W., additional, Behrens, J., additional, Brann, L., additional, Brown, D., additional, Carr, H., additional, Churchwell, K., additional, Comingore, G.A., additional, Corbett, J., additional, Costello, M., additional, Cruz, F., additional, Depinet, T., additional, Dorbala, S., additional, Earles, M., additional, Esteves, F.P., additional, Etherton, E., additional, Fanning, R.J., additional, Fornace, J., additional, Franks, L., additional, Gewirtz, H., additional, Gulanchyn, K., additional, Hannah, C.-L., additional, Hays, J., additional, Hendrickson, J., additional, Hester, J., additional, Holmes, K., additional, Johnson, A., additional, Jopek, C., additional, Lewin, H., additional, Lyons, J., additional, Manley, C., additional, Meden, J., additional, Moore, S., additional, Moore, W.H., additional, Murthy, V., additional, Nace, R., additional, Neely, D., additional, Nelson, L., additional, Niedermaier, O., additional, Rice, D., additional, Rigs, R., additional, Schiffer, K., additional, Schockling, E., additional, Schultz, T., additional, Schumacker, T., additional, Sheesley, B., additional, Sheikh, A., additional, Siegel, B., additional, Slim, A.M., additional, Smith, J., additional, Szulc, M., additional, Tanskersley, N., additional, Tilkemeier, P., additional, Valdez, G.D., additional, Vrooman, R., additional, Wawrowicz, D., additional, Winchester, D.E., additional, Alcheikh, A., additional, Allen, B., additional, Atkins, E., additional, Bevan, J., additional, Bonomini, C., additional, Christiansen, J., additional, Clack, L., additional, Craig, E., additional, Dixson, H., additional, Duncan, I., additional, Fredericks, S., additional, Gales, S., additional, Hampson, R., additional, Hanley, T., additional, Hartcher, K., additional, Hassall, J., additional, Kelley, B., additional, Kelly, S., additional, Kidd, T., additional, de Kort, T., additional, Larcos, G., additional, Macdonald, W., additional, McGrath, C., additional, Murdoch, E., additional, O'Malley, S., additional, O'Rourke, M., additional, Pack, M., additional, Pearce, R., additional, Praehofer, R., additional, Ramsay, S., additional, Scarlett, L., additional, Smidt, K., additional, Souvannavong, F., additional, Taubman, K., additional, Taylor, G., additional, Tse, K., additional, Unger, S., additional, and Weale, J., additional

Published
2021
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43. 68Ga-DOTATOC PET/MR imaging and radiomic parameters in predicting histopathological prognostic factors in patients with pancreatic neuroendocrine well-differentiated tumours.

Author

Mapelli, P., Bezzi, C., Palumbo, D., Canevari, C., Ghezzo, S., Samanes Gajate, A. M., Catalfamo, B., Messina, A., Presotto, L., Guarnaccia, A., Bettinardi, V., Muffatti, F., Andreasi, V., Schiavo Lena, M., Gianolli, L., Partelli, S., Falconi, M., Scifo, P., De Cobelli, F., and Picchio, M.

Subjects
SOMATOSTATIN, HISTOPATHOLOGY, NEUROENDOCRINE tumors, TUMORS, NEUROENDOCRINE system
Abstract

Purpose: To explore the role of fully hybrid 68Ga-DOTATOC PET/MR imaging and radiomic parameters in predicting histopathological prognostic factors in patients with pancreatic neuroendocrine tumours (PanNETs) undergoing surgery. Methods: One hundred eighty-seven consecutive 68Ga-DOTATOC PET/MRI scans (March 2018–June 2020) performed for gastroenteropancreatic neuroendocrine tumour were retrospectively evaluated; 16/187 patients met the eligibility criteria (68Ga-DOTATOC PET/MRI for preoperative staging of PanNET and availability of histological data). PET/MR scans were qualitatively and quantitatively interpreted, and the following imaging parameters were derived: PET-derived SUVmax, SUVmean, somatostatin receptor density (SRD), total lesion somatostatin receptor density (TLSRD), and MRI-derived apparent diffusion coefficient (ADC), arterial and late enhancement, necrosis, cystic degeneration, and maximum diameter. Additionally, first-, second-, and higher-order radiomic parameters were extracted from both PET and MRI scans. Correlations with several PanNETs' histopathological prognostic factors were evaluated using Spearman's coefficient, while the area under the curve (AUC) of the receiver operating characteristic (ROC) curve was used to evaluate parameters' predictive performance. Results: Primary tumour was detected in all 16 patients (15/16 by 68Ga-DOTATOC PET and 16/16 by MRI). SUVmax and SUVmean resulted good predictors of lymphnodal (LN) involvement (AUC of 0.850 and 0.783, respectively). Second-order radiomic parameters GrayLevelVariance and HighGrayLevelZoneEmphasis extracted from T2 MRI demonstrated significant correlations with LN involvement (adjusted p = 0.009), also showing good predictive performance (AUC = 0.992). Conclusion: This study demonstrates the role of the fully hybrid PET/MRI tool for the synergic function of imaging parameters extracted by the two modalities and highlights the potentiality of imaging and radiomic parameters in assessing histopathological features of PanNET aggressiveness. [ABSTRACT FROM AUTHOR]

Published
2022
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44. PH-0717: Locally Advanced Pancreatic Cancer: Robust Radiomic based model of outcome after radiochemotherapy

Author

Mori, M., primary, Passoni, P., additional, Incerti, E., additional, Broggi, S., additional, Cattaneo, G.M., additional, Reni, M., additional, Spezi, E., additional, Slim, N., additional, Vanoli, E.G., additional, Bettinardi, V., additional, Gianolli, L., additional, Picchio, M., additional, Di Muzio, N.G., additional, and Fiorino, C., additional

Published
2020
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45. The role of 18F-FAZA PET/CT in detecting lymph node metastases in renal cell carcinoma patients: a prospective pilot trial (NCT03955393)

Author

Capitanio, U., primary, Pepe, G., additional, Incerti, E., additional, Larcher, A., additional, Trevisani, F., additional, Lucianò, R., additional, Mapelli, P., additional, Bettinardi, V., additional, Menterisi, C., additional, Necchi, A., additional, Cascinu, S., additional, Bernardi, R., additional, Bertini, R., additional, Doglioni, C., additional, Gianolli, L., additional, Salonia, A., additional, Picchio, M., additional, and Montorsi, F., additional

Published
2020
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46. Corrigendum to 'Sentinel node biopsy after primary systemic therapy in node positive breast cancer patients: Time trend, imaging staging power and nodal downstaging according to molecular subtype' (European Journal of Surgical Oncology (2019) 45(6) (969–975), (S0748798319302458), (10.1016/j.ejso.2019.01.219))

Author

Di Micco R., Zuber V., Fiacco E., Carriero F., Gattuso M. I., Nazzaro L., Panizza P., Gianolli L., Canevari C., Di Muzio N., Pasetti M., Sassi I., Zambetti M., Gentilini O. D., Di Micco, R., Zuber, V., Fiacco, E., Carriero, F., Gattuso, M. I., Nazzaro, L., Panizza, P., Gianolli, L., Canevari, C., Di Muzio, N., Pasetti, M., Sassi, I., Zambetti, M., and Gentilini, O. D.

Abstract

The authors regret that the author list in reference 27 was written incorrectly and should have been as follows: 27. M. Donker, M.E Straver, J. Wesseling, C.E. Loo, M. Schot, C.A Drukker et al. Marking axillary lymph nodes with radioactive iodine seeds for axillary staging after neoadjuvant systemic treatment in breast cancer patients: the MARI procedure. Ann Surg, 261 (2) (2015), pp. 378-382 The authors would like to apologise for any inconvenience caused.

Published
2019

48. Low-dose CT for the spatial normalization of PET images: A validation procedure for amyloid-PET semi-quantification

Author

Presotto, L, Iaccarino, L, Sala, A, Vanoli, E, Muscio, C, Nigri, A, Bruzzone, M, Tagliavini, F, Gianolli, L, Perani, D, Bettinardi, V, Presotto L., Iaccarino L., Sala A., Vanoli E. G., Muscio C., Nigri A., Bruzzone M. G., Tagliavini F., Gianolli L., Perani D., Bettinardi V., Presotto, L, Iaccarino, L, Sala, A, Vanoli, E, Muscio, C, Nigri, A, Bruzzone, M, Tagliavini, F, Gianolli, L, Perani, D, Bettinardi, V, Presotto L., Iaccarino L., Sala A., Vanoli E. G., Muscio C., Nigri A., Bruzzone M. G., Tagliavini F., Gianolli L., Perani D., and Bettinardi V.

Abstract

The reference standard for spatial normalization of brain positron emission tomography (PET) images involves structural Magnetic Resonance Imaging (MRI) data. However, the lack of such structural information is fairly common in clinical settings. This might lead to lack of proper image quantification and to evaluation based only on visual ratings, which does not allow research studies or clinical trials based on quantification. PET/CT systems are widely available and CT normalization procedures need to be explored. Here we describe and validate a procedure for the spatial normalization of PET images based on the low-dose Computed Tomography (CT) images contextually acquired for attenuation correction in PET/CT systems. We included N = 34 subjects, spanning from cognitively normal to mild cognitive impairment and dementia, who underwent amyloid-PET/CT (18F-Florbetaben) and structural MRI scans. The proposed pipeline is based on the SPM12 unified segmentation algorithm applied to low-dose CT images. The validation of the normalization pipeline focused on 1) statistical comparisons between regional and global 18F-Florbetaben-PET/CT standardized uptake value ratios (SUVrs) estimated from both CT-based and MRI-based normalized PET images (SUVrCT SUVrMRI) and 2) estimation of the degrees of overlap between warped gray matter (GM) segmented maps derived from CT- and MRI-based spatial transformations. We found negligible deviations between regional and global SUVrs in the two CT and MRI-based methods. SUVrCT and SUVrMRI global uptake scores showed negligible differences (mean ± sd 0.01 ± 0.03). Notably, the CT- and MRI-based warped GM maps showed excellent overlap (90% within 1 mm). The proposed analysis pipeline, based on low-dose CT images, allows accurate spatial normalization and subsequent PET image quantification. A CT-based analytical pipeline could benefit both research and clinical practice, allowing the recruitment of larger samples and favoring clinical routine a

Published
2018

49. Carotid artery plaque uptake of 11C-PK11195 inversely correlates with circulating monocytes and classical CD14++CD16− monocytes expressing HLA-DR

Author

Ammirati, E, Moroni, F, Magnoni, M, Busnardo, E, Di Terlizzi, S, Villa, C, Sizzano, F, Scotti, I, Palini, A, Presotto, L, Bettinardi, V, Spagnolo, P, Besana, F, Gianolli, L, Rimoldi, O, Camici, P, Ammirati E., Moroni F., Magnoni M., Busnardo E., Di Terlizzi S., Villa C., Sizzano F., Scotti I., Palini A., Presotto L., Bettinardi V., Spagnolo P., Besana F., Gianolli L., Rimoldi O. E., Camici P. G., Ammirati, E, Moroni, F, Magnoni, M, Busnardo, E, Di Terlizzi, S, Villa, C, Sizzano, F, Scotti, I, Palini, A, Presotto, L, Bettinardi, V, Spagnolo, P, Besana, F, Gianolli, L, Rimoldi, O, Camici, P, Ammirati E., Moroni F., Magnoni M., Busnardo E., Di Terlizzi S., Villa C., Sizzano F., Scotti I., Palini A., Presotto L., Bettinardi V., Spagnolo P., Besana F., Gianolli L., Rimoldi O. E., and Camici P. G.

Abstract

Background: We explored the relation between blood concentrations of monocyte/lymphocyte subsets and carotid artery plaque macrophage content, measured by positron emission tomography (PET) with 11C-PK11195. Methods and results: In 9 patients with carotid plaques we performed 11C-PK11195-PET/computed tomography angiography imaging and measurement of absolute concentrations and frequencies of circulating monocytes and T-cell subsets. Plaque standardized uptake value (SUV) for 11C-PK11195 was negatively correlated with concentrations of total monocytes (r = −0.58, p = 0.05) and CD14++CD16−HLA-DR+ classical subset (r = −0.82, p = 0.005). These correlations hold true also in relation to plaque target to background ratio. No correlation was observed between plaque SUV and CD3+T lymphocytes, CD4+T lymphocytes nor with activated CD3+CD4+T cells expressing HLA-DR. Conclusions: We first demonstrated a reduction in the absolute concentration of monocytes and particularly in classical monocytes expressing HLA-DR in the presence of an increased uptake of 11C-PK11195 in carotid plaques. The present work, despite being a pilot study comprising only a small number of subjects provides new insights in the search for specific cellular biomarkers with potential diagnostic and prognostic value in patients with a known carotid plaque.

Published
2018

50. An in vivo 11C-PK PET study of microglia activation in Fatal Familial Insomnia

Author

Iaccarino, L, Presotto, L, Bettinardi, V, Gianolli, L, Roiter, I, Capellari, S, Parchi, P, Cortelli, P, Perani, D, Iaccarino L., Presotto L., Bettinardi V., Gianolli L., Roiter I., Capellari S., Parchi P., Cortelli P., Perani D., Iaccarino, L, Presotto, L, Bettinardi, V, Gianolli, L, Roiter, I, Capellari, S, Parchi, P, Cortelli, P, Perani, D, Iaccarino L., Presotto L., Bettinardi V., Gianolli L., Roiter I., Capellari S., Parchi P., Cortelli P., and Perani D.

Abstract

Objective: Postmortem studies reported significant microglia activation in association with neuronal apoptosis in Fatal Familial Insomnia (FFI), indicating a specific glial response, but negative evidence also exists. An in vivo study of local immune responses over FFI natural course may contribute to the understanding of the underlying pathogenesis. Methods: We included eight presymptomatic subjects (mean ± SD age:44.13 ± 3.83 years) carrying the pathogenic D178N-129met FFI mutation, one symptomatic patient (male, 45 yrs. old), and nine healthy controls (HC) (mean ± SD age: 44.00 ± 11.10 years.) for comparisons. 11C-(R)-PK11195 PET allowed the measurement of Translocator Protein (TSPO) overexpression, indexing microglia activation. A clustering algorithm was adopted to define subject-specific reference regions. Voxel-wise statistical analyses were performed on 11C-(R)-PK11195 binding potential (BP) images both at the group and individual level. Results: The D178N-129met/val FFI patient showed significant 11C-(R)-PK11195 BP increases in the midbrain, cerebellum, anterior thalamus, anterior cingulate cortex, orbitofrontal cortex, and anterior insula, bilaterally. Similar TSPO increases, but limited to limbic structures, were observed in four out of eight presymptomatic carriers. The only carrier with the codon 129met/val polymorphism was the only one showing an additional TSPO increase in the anterior thalamus. Interpretation: In comparison to nonprion neurodegenerative diseases, the observed lack of a diffuse brain TSPO overexpression in preclinical and the clinical FFI cases suggests the presence of a different microglia response. The involvement of limbic structures might indicate a role for microglia activation in these key pathologic regions, known to show the most significant neuronal loss and functional deafferentation in FFI.

Published
2018

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