Author: "Gianpiero Tonnarelli" - Searchworks@Jio Institute Digital Library Search Results

Author: Giovanni Lasio, Sergio Visintini, Laura Valentini, Francesco Di Meco, Paolo Roccucci, Giancarlo Nicola, Gianpiero Tonnarelli, and Carlo L. Solero
Subjects: medicine.medical_specialty, business.industry, Skull base surgery, medicine, business, Surgery
Published: 2015

Author: Giancarlo Nicola, Roberto Freschi, Fabio Cammelli, Gianpiero Tonnarelli, Edoardo Sala, Gianluigi Spreafico, Franco Zancaner, and Genziana Gadola
Subjects: Brain tumor, Perfusion scanning, law.invention, chemistry.chemical_compound, Technetium Tc 99m Exametazime, law, Oximes, medicine, Organometallic Compounds, Humans, Radiology, Nuclear Medicine and imaging, Gamma camera, Brain Diseases, medicine.diagnostic_test, business.industry, Brain, General Medicine, medicine.disease, Oxime, Hydrocephalus, chemistry, Cerebral blood flow, Positron emission tomography, Cerebrovascular Circulation, Tomography, business, Nuclear medicine, Tomography, X-Ray Computed, Tomography, Emission-Computed
Abstract: A recently developed 99mTc radiocompound, hexamethyl-propyleneamine oxime (99mTc-HM-PAO) exhibits favorable properties for regional cerebral tomograms in man utilizing conventional instrumentation (SPECT). Planar and tomographic studies using a rotating gamma camera equipped with a high sensitivity, low energy, collimator were performed in 5 normal subjects and 20 patients suffering from different cerebral diseases. SPECT abnormalities observed in patients with CVD, brain tumors and hydrocephalus were compared with results from X-ray CT. Our preliminary study demonstrates the feasibility of assessing regional brain perfusion using SPECT and a 99mTc radiopharmaceutical which is lipid soluble and has a high extraction fraction in the brain.
Published: 1987

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