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2. Clustering Analysis to Profile Customers’ Behaviour in POWER CLOUD Energy Community

Author

Gabriele, Lorella, Bertacchini, Francesca, Giglio, Simona, Menniti, Daniele, Pantano, Pietro, Pinnarelli, Anna, Sorrentino, Nicola, Bilotta, Eleonora, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Sergeyev, Yaroslav D., editor, and Kvasov, Dmitri E., editor

Published
2020
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6. Supplementary Figure 2 from Identification of an Aberrantly Spliced Form of HDMX in Human Tumors: A New Mechanism for HDM2 Stabilization

Author

Giglio, Simona, primary, Mancini, Francesca, primary, Gentiletti, Francesca, primary, Sparaco, Giorgia, primary, Felicioni, Lara, primary, Barassi, Fabio, primary, Martella, Carla, primary, Prodosmo, Andrea, primary, Iacovelli, Stefano, primary, Buttitta, Fiamma, primary, Farsetti, Antonella, primary, Soddu, Silvia, primary, Marchetti, Antonio, primary, Sacchi, Ada, primary, Pontecorvi, Alfredo, primary, and Moretti, Fabiola, primary

Published
2023
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7. Supplementary Figure 1 from Identification of an Aberrantly Spliced Form of HDMX in Human Tumors: A New Mechanism for HDM2 Stabilization

Author

Giglio, Simona, primary, Mancini, Francesca, primary, Gentiletti, Francesca, primary, Sparaco, Giorgia, primary, Felicioni, Lara, primary, Barassi, Fabio, primary, Martella, Carla, primary, Prodosmo, Andrea, primary, Iacovelli, Stefano, primary, Buttitta, Fiamma, primary, Farsetti, Antonella, primary, Soddu, Silvia, primary, Marchetti, Antonio, primary, Sacchi, Ada, primary, Pontecorvi, Alfredo, primary, and Moretti, Fabiola, primary

Published
2023
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8. Circulating U13 Small Nucleolar RNA as a Potential Biomarker in Huntington’s Disease: A Pilot Study

Author

Romano, Silvia, primary, Romano, Carmela, additional, Peconi, Martina, additional, Fiore, Alessia, additional, Bellucci, Gianmarco, additional, Morena, Emanuele, additional, Troili, Fernanda, additional, Cipollini, Virginia, additional, Annibali, Viviana, additional, Giglio, Simona, additional, Mechelli, Rosella, additional, Ferraldeschi, Michela, additional, Veneziano, Liana, additional, Mantuano, Elide, additional, Sani, Gabriele, additional, Vecchione, Andrea, additional, Umeton, Renato, additional, Giubilei, Franco, additional, Salvetti, Marco, additional, Corbo, Rosa Maria, additional, Scarabino, Daniela, additional, and Ristori, Giovanni, additional

Published
2022
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9. Circulating U13 small nucleolar RNA as a candidate biomarker for Huntington’s disease

Author

Romano, Silvia, primary, Romano, Carmela, additional, Peconi, Martina, additional, Fiore, Alessia, additional, Bellucci, Gianmarco, additional, Morena, Emanuele, additional, Troili, Fernanda, additional, Cipollini, Virginia, additional, Annibali, Viviana, additional, Giglio, Simona, additional, Mechelli, Rosella, additional, Ferraldeschi, Michela, additional, Veneziano, Liana, additional, Mantuano, Elide, additional, Sani, Gabriele, additional, Vecchione, Andrea, additional, Umeton, Renato, additional, Giubilei, Franco, additional, Salvetti, Marco, additional, Corbo, Rosa Maria, additional, Scarabino, Daniela, additional, and Ristori, Giovanni, additional

Published
2022
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10. A microRNA signature defines chemoresistance in ovarian cancer through modulation of angiogenesis

Author

Vecchione, Andrea, Belletti, Barbara, Lovat, Francesca, Volinia, Stefano, Chiappetta, Gennaro, Giglio, Simona, Sonego, Maura, Cirombella, Roberto, Onesti, Elisa Concetta, Pellegrini, Patrizia, Califano, Daniela, Pignata, Sandro, Losito, Simona, Canzonieri, Vincenzo, Sorio, Roberto, Alder, Hansjuerg, Wernicke, Dorothee, Stoppacciaro, Antonella, Baldassarre, Gustavo, and Croce, Carlo M.

Published
2013

15. Circulating hsa-miR-323b-3p in Huntington's Disease: A Pilot Study

Author

Ferraldeschi, Michela, primary, Romano, Silvia, additional, Giglio, Simona, additional, Romano, Carmela, additional, Morena, Emanuele, additional, Mechelli, Rosella, additional, Annibali, Viviana, additional, Ubaldi, Martina, additional, Buscarinu, Maria Chiara, additional, Umeton, Renato, additional, Sani, Gabriele, additional, Vecchione, Andrea, additional, Salvetti, Marco, additional, and Ristori, Giovanni, additional

Published
2021
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16. Impairment of autophagy may represent the molecular mechanism behind the relationship between obesity and inflammation in patients with BPH and LUTS

Author

De Nunzio, Cosimo, Giglio, Simona, Baldassarri, Valeria, Cirombella, Roberto, Mallel, Giuseppe, Nacchia, Antonio, Tubaro, Andrea, and Vecchione, Andrea

Subjects
Inflammation, Male, Urology, Prostatic Hyperplasia, Transurethral Resection of Prostate, Middle Aged, Lower Urinary Tract Symptoms, Nephrology, luts, Autophagy, Humans, Obesity, autophagy, inflammation, Aged
Abstract

Aim of this study was to evaluate the roles of inflammation and autophagy in obese patients with benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS).We analyzed 150 surgical specimens from patients underwent transurethral resection of the prostate (TURP) for LUTS/BPH (Median age 70.3±8.1 years, median BMI 25.7±4.0 kg/mOverall 74/150 (49.3%) patients were overweight or obese (BMI25 kg/mHere we confirm the association between obesity and prostatic inflammatory infiltrates and present the first evidence of autophagy deregulation in obese patients with LUTS/BPH. Further studies should better investigate this relationship and provide new possible therapeutic targets.

Published
2020

21. miRNAs as Candidate Biomarker for the Accurate Detection of Atypical Endometrial Hyperplasia/Endometrial Intraepithelial Neoplasia

Author

Giglio, Simona, primary, Annibali, Viviana, additional, Cirombella, Roberto, additional, Faruq, Omar, additional, Volinia, Stefano, additional, De Vitis, Claudia, additional, Pesce, Margherita, additional, Caserta, Donatella, additional, Pettinato, Angela, additional, Fraggetta, Filippo, additional, and Vecchione, Andrea, additional

Published
2019
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22. Analysis of coding and non-coding transcriptome of peripheral B cells reveals an altered interferon response factor (IRF)-1 pathway in multiple sclerosis patients

Author

Annibali, Viviana, primary, Umeton, Renato, additional, Palermo, Antonia, additional, Severa, Martina, additional, Etna, Marilena Paola, additional, Giglio, Simona, additional, Romano, Silvia, additional, Ferraldeschi, Michela, additional, Buscarinu, Maria Chiara, additional, Vecchione, Andrea, additional, Annese, Anita, additional, Policano, Claudia, additional, Mechelli, Rosella, additional, Pizzolato Umeton, Raffaella, additional, Fornasiero, Arianna, additional, Angelini, Daniela Francesca, additional, Guerrera, Gisella, additional, Battistini, Luca, additional, Coccia, Eliana Marina, additional, Salvetti, Marco, additional, and Ristori, Giovanni, additional

Published
2018
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23. Machine learning and points of interest: typical tourist Italian cities.

Author

Giglio, Simona, Bertacchini, Francesca, Bilotta, Eleonora, and Pantano, Pietro

Subjects
MACHINE learning, CLUSTER analysis (Statistics), TOURISTS, SOCIAL networks, SOCIAL media
Abstract

Today georeferenced images posted on the social network provide a lot of information about people behaviours and movements. Using social media platforms users upload photos, share locations and post comments about their activities, influencing other people. In this research, we examine the relationship between human mobility and touristic attractions through geo-located images provided by Flickr users. A sample of 26,392 pictures related to 6 Italian cities has been collected and analysed applying cluster analysis. In our work, the function of the clustering analysis, employed in Wolfram Mathematica Machine Learning, allows one to automatically identify clusters surrounding points of interest (POIs). Findings show that social media datasets are valuable data to understand tourist behaviour and mobility within a location. The scope is to delineate famous or unpopular places and propose new touristic scenarios, highlighting how the social part covers the main role in the POIs' recommendation process in the touristic field. Furthermore, we aim to promote the machine learning approach as a useful support in human behaviour research. [ABSTRACT FROM AUTHOR]

Published
2020
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28. Papillary Carcinoma of the Thyroid: High Expression of COX-2 and Low Expression of KAI-1/CD82 Are Associated with Increased Tumor Invasiveness

Author

Stefania, Scarpino, Enrico, Duranti, Giglio, Simona, DI NAPOLI, Arianna, Dino, Galafate, Donatella Del Bufalo, Marianna, Desideri, Socciareli, F., Fabio, Socciarelli, Stoppacciaro, Antonella, and Ruco, Luigi

Subjects
Adult, Male, Pathology, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Primary Cell Culture, Mice, Nude, Biology, Kangai-1 Protein, Transfection, Young Adult, Endocrinology, Downregulation and upregulation, Cell Movement, Cell Line, Tumor, medicine, Tumor Cells, Cultured, Animals, Humans, Metastasis suppressor, Neoplasm Invasiveness, Thyroid Neoplasms, Aged, Cyclooxygenase 2 Inhibitors, Thyroid, Carcinoma, Cell migration, Middle Aged, Carcinoma, Papillary, medicine.anatomical_structure, Cell culture, Cyclooxygenase 2, Thyroid Cancer, Papillary, Lymphatic Metastasis, Cancer research, Hepatocyte growth factor, Female, CD82, medicine.drug, Signal Transduction
Abstract

We have previously demonstrated that expression of COX-2 is upregulated by hepatocyte growth factor in thyroid papillary carcinoma (TPC) cells and is associated with increased invasiveness of tumor cells. COX-2 upregulation was associated with downregulation of KAI-1/CD82, a metastasis suppressor molecule that has been associated with the metastatic potential of several solid tumors. In the present study, we have investigated the possibility that downregulation of KAI-1/CD82 may contribute to the invasiveness of papillary carcinoma cells.Expression of KAI-1/CD82 and its relation to COX-2 levels were investigated in 6 primary cultures of TPC, in 2 tumor cell lines (TPC-1 and K1), and in 55 tumor samples of TPC. The biological role of KAI-1/CD82 in regulating tumor invasiveness was investigated in TPC cell lines and primary cultures transfected with a pCDNA3.1/Hygro.KAI-1; transfected cells were tested in functional studies of cell migration and invasiveness. Finally, the role of KAI-1/CD82 in influencing TPC metastasis was investigated in vivo using nu/nu mice injected with K1-transfected cells.We provide evidence that COX-2 and KAI-1/CD82 are inversely regulated in TPC primary cultures and in TPC-1 tumor cells. In fact, inhibition of COX-2 with NS398 is associated with a 2-9-fold upregulation of KAI-1/CD82 RNA. Moreover, a possible relation between COX-2 and KAI-1/CD82 was confirmed by the presence of a statistically significant inverse correlation in the expression of the two genes in 55 tumor samples of TPC (r = -0.513; p = 0.001). In 36 of 55 cases, tumor areas contained lower levels of KAI-1/CD82 RNA as compared with the corresponding normal tissue. Low expression of KAI-1/CD82 RNA in the tumor area was associated with extrathyroid extension of the disease in 16 of 19 cases (p0.04) and with lymph node metastasis in 11 of 14 cases (not significant). KAI-1/CD82 re-expression in tumor cells was associated with a significant decrease in their migratory (50-76% reduction) and invasive (46-65% reduction) capacity, even after hepatocyte growth factor stimulation. Finally, nu/nu mice injected with KAI-1/CD82-transfected K1 TPC cells developed fewer and smaller metastasis as compared with mice injected with vector-transfected K1 cells (p=0.016).Our findings raise the possibility that downregulation of KAI-1/CD82 in TPC cells is one of the molecular mechanisms regulating their invasive and metastatic potential.

Published
2013

33. Papillary Carcinoma of the Thyroid: High Expression of COX-2 and Low Expression of KAI-1/CD82 Are Associated with Increased Tumor Invasiveness

Author

Scarpino, Stefania, primary, Duranti, Enrico, additional, Giglio, Simona, additional, Di Napoli, Arianna, additional, Galafate, Dino, additional, Del Bufalo, Donatella, additional, Desideri, Marianna, additional, Socciarelli, Fabio, additional, Stoppacciaro, Antonella, additional, and Ruco, Luigi, additional

Published
2013
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36. MDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathway

Author

Mancini, Francesca, primary, Di Conza, Giusy, additional, Pellegrino, Marsha, additional, Rinaldo, Cinzia, additional, Prodosmo, Andrea, additional, Giglio, Simona, additional, D'Agnano, Igea, additional, Florenzano, Fulvio, additional, Felicioni, Lara, additional, Buttitta, Fiamma, additional, Marchetti, Antonio, additional, Sacchi, Ada, additional, Pontecorvi, Alfredo, additional, Soddu, Silvia, additional, and Moretti, Fabiola, additional

Published
2009
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37. Identification of an Aberrantly Spliced Form of HDMX in Human Tumors: A New Mechanism for HDM2 Stabilization

Author

Giglio, Simona, primary, Mancini, Francesca, additional, Gentiletti, Francesca, additional, Sparaco, Giorgia, additional, Felicioni, Lara, additional, Barassi, Fabio, additional, Martella, Carla, additional, Prodosmo, Andrea, additional, Iacovelli, Stefano, additional, Buttitta, Fiamma, additional, Farsetti, Antonella, additional, Soddu, Silvia, additional, Marchetti, Antonio, additional, Sacchi, Ada, additional, Pontecorvi, Alfredo, additional, and Moretti, Fabiola, additional

Published
2005
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39. Micro RNA mi R-24 promotes cell proliferation by targeting the CDKs inhibitors p27Kip1 and p16INK4a.

Author

Giglio, Simona, Cirombella, Roberto, Amodeo, Rachele, Portaro, Luciano, Lavra, Luca, and Vecchione, Andrea

Subjects
*MICRORNA, *CELL proliferation, *CYCLIN-dependent kinase inhibitors, *GENE targeting, *CELL cycle, *CELL division, *NON-coding RNA, *GENE expression
Abstract

Cell cycle progression is controlled by numerous mechanisms ensuring correct cell division. The transition from one cell cycle phase to another occurs in an orderly fashion and is regulated by different cellular proteins. Therefore an alteration of the regulatory mechanisms of the cell cycle results in uncontrolled cell proliferation, which is a distinctive feature of human cancers. Recent evidences suggest that microRNAs (miRs) may also control the levels of multiple cell cycle regulators and therefore control cell proliferation. In fact miRs are a class of small non-coding RNAs, which modulate gene expression. They are involved in numerous physiological cellular processes and most importantly accumulating evidence indicates that many miRs are aberrantly expressed in human cancers. In this report we describe that miR-24 directly targets p27Kip1 and p16Ink4a in primary keratinocyte and in different cancer derived cell lines promoting their proliferation, suggesting that miR-24 is involved in cyclin-dependent kinase inhibitors post-transcriptional regulation and that upregulation of miR-24 may play a role in carcinogenesis. J. Cell. Physiol. 228: 2015-2023, 2013. © 2013 Wiley Periodicals, Inc. [ABSTRACT FROM AUTHOR]

Published
2013
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40. Micro RNA mi R-24 promotes cell proliferation by targeting the CDKs inhibitors p27Kip1 and p16INK4a.

Author

Giglio, Simona, Cirombella, Roberto, Amodeo, Rachele, Portaro, Luciano, Lavra, Luca, and Vecchione, Andrea

Subjects
MICRORNA, CELL proliferation, CYCLIN-dependent kinase inhibitors, GENE targeting, CELL cycle, CELL division, NON-coding RNA, GENE expression
Abstract

Cell cycle progression is controlled by numerous mechanisms ensuring correct cell division. The transition from one cell cycle phase to another occurs in an orderly fashion and is regulated by different cellular proteins. Therefore an alteration of the regulatory mechanisms of the cell cycle results in uncontrolled cell proliferation, which is a distinctive feature of human cancers. Recent evidences suggest that microRNAs (miRs) may also control the levels of multiple cell cycle regulators and therefore control cell proliferation. In fact miRs are a class of small non-coding RNAs, which modulate gene expression. They are involved in numerous physiological cellular processes and most importantly accumulating evidence indicates that many miRs are aberrantly expressed in human cancers. In this report we describe that miR-24 directly targets p27Kip1 and p16Ink4a in primary keratinocyte and in different cancer derived cell lines promoting their proliferation, suggesting that miR-24 is involved in cyclin-dependent kinase inhibitors post-transcriptional regulation and that upregulation of miR-24 may play a role in carcinogenesis. J. Cell. Physiol. 228: 2015-2023, 2013. © 2013 Wiley Periodicals, Inc. [ABSTRACT FROM AUTHOR]

Published
2013
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