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The typical changes of hemostasis indicators in different periods of gestation are described. The analysis of blood plasma in pregnant women with menace of miscarriage and compromised anamnestic record on spontaneous or attempted abortion was made. The valid hypercoagulation deviations are detected. They are manifested in the decrease of international normalized ratio indicators and index of activated partial thromboplastin time, the increase of level of soluble fibrin-monomeric complex against the background of mild hyperfibrinogenemia and decrease of activity of plasminogen, antihtrombin III and protein C. The lupousus anticoagulant and Leiden mutation occurred more often. The evidence of changes differed depending of presence of complications in the anamnesis and current menace of miscarriage. The established thrombofilic shifts can play certain pathogenic role in development of noncarrying of pregnancy.

The article deals with the data concerning DNA-citometry of peripheral blood cells in healthy children and under particular pathologic conditions. The causes of shifts are discussed as their possible role in pathogenesis and clinical diagnostics of diseases as well.

The efficiency of applying precision devices and multiple laboratory methods devised to reveal the causes of bleeding and thromboses significantly depends on whether a wide range of rules of the preanalytical stage of the study is observed. The paper gives detailed information on conditions for taking blood samples, their transport, and preparation for examination of the hemostatic system. The given information is based on the worldwide recommendations and many years' experience gained by the authors at the laboratory of hemostasis.

The article gives an experimental assessment of processes of healing anastomoses of hollow organs using preparation "Enterosan". "Enterosan" decreases inflammatory alterations and accelerates processes of reparative regeneration in the anastomosis zone.

Statistical analysis has established the importance and adequacy of determination of the levels of circulating immune complexes, leukocytes, and HLA-DR+ lymphocytes for the prediction of the outcome of treatment for surgical sepsis. A model of prognostically best clinical outcome of the disease was used to calculate the ranges of values of immunological parameters in which it is expedient to use immunovenin, imunofan, inferon, roncoleukin, and ceruloplasmin in order to have an optimal clinical effect; moreover, there was a 76% agreement of the actual results of treatment with calculated ones.

The analysis of enterosan influence on intestinal anastomosis healing in 90 rats was carried out. The medication is highly active as a regeneration stimulator. The use of enterosan decreases inflammation and activates regeneration in anastomosis area.

The investigation determined whether there was a relationship of thyroid diseases with the geology of the place of residence and its associated spectrum of trace elements (iron, chromium, selenium, manganese, cobalt, copper, nickel, arsenic, and zinc). The geologo-geomorphological factors of the habitat, such as geological formations (mineral composition, structure, the degree of rock metamorphism), tectonics, the history of geological development, relief, paleorelief, were found to be of considerable importance in the formation of the human trace element status. Both deficiency and excess of trace elements was shown to be of pathogenetic value in the development of thyroid diseases. Residence in the area wherein carbonate rocks are predominant contributes to an increase in incidence of thyroid diseases.

We studied the functional and metabolic changes of erythrocytes in systemic vasculitis (SV). The below was detected: an increasing intensity of blood chemiluminescence, a higher concentration of TBA-positive substances in erythrocyte membranes, inhibited Na+, K+ - and Ca2+ -activated and Mg2+ -related ATPases in erythrocytes and a reduced osmotic and acidic resistance of erythrocytes. An enhanced aggregation ability of erythrocytes and their inhibited desagregation were observed in hemorrhagic vasculitis an especially in microscopic polyangiitis. The revealed changes characterize the significance of the erythrocyte pathology in thrombosis and development of hemorrhagic disorders in SV patients.

Data on the impact exerted by industrial products, i.e. pyromellitic dianhydride, on the acidic and osmotic resistance of erythrocytes in workers are described. The influence of hazardous factors of the oil-and-chemical production was found to result in a changing erythrocytes' resistance (of workers) to the osmotic and acidic hemolytics with regard for a labor record and duration of contact with toxicants. The shifts in acidic and osmotic resistance can serve as an early marker of changes in the functional erythron's status in workers occupied under hazardous industrial factors.

The article presents studies of hormonal state in rats under daily or 20-day peroral administration of variable doses of 2,4-D herbicide containing dioxine. Changed levels of thyroid hormones, insulin, cortisol, testosterone and estradiol appeared to be divergent and dose-dependent, proving direct toxic effects of the herbicide in endocrine organs, altered hormonal effects in target organs and disorders of peripheral hormonal metabolism.