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157 results on '"Gilbert, John W."'

5. Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

Author

Lauren, Juha, Gimbel, David A., Nygaard, Haakon B., Gilbert, John W., and Strittmatter, Stephen M.

Subjects
Amyloid beta-protein -- Physiological aspects -- Research, Prions -- Physiological aspects -- Research, Neuroplasticity -- Research -- Physiological aspects, Environmental issues, Science and technology, Zoology and wildlife conservation, Physiological aspects, Research
Abstract

A pathological hallmark of Alzheimer's disease is an accumulation of insoluble plaque containing the amyloid-β peptide of 40-42 amino acid residues (1). Prefibrillar, soluble oligomers of amyloid-β have been recognized to be early and key intermediates in Alzheimer's-disease-related synaptic dysfunction (2-9). At nanomolar concentrations, soluble amyloid-β oligomers block hippocampal long-term potentiation (7), cause dendritec spine retraction from pyramidal cells (5,8) and impair rodent spatial memory (2). Soluble amyloid-β oligomers have been prepared from chemical syntheses, transfected cell culture supernatants, transgenic mouse brain and human Alzheimer's disease brain (2,4,7,9). Together, these data imply a high-affinity cell-surface receptor for soluble amyloid-β oligomers on neurons-one that is central to the pathophysiological process in Alzheimer's disease. Here we identify the cellular prion protein ([PrP.sup.C]) as an amyloid-β-oligomer receptor by expression cloning. Amyloid-β oligomers bind with nanomolar affinity to [PrP.sup.C], but the interaction does not require the infectious [PrP.sup.Sc] conformation. Synaptic responsiveness in hippocampal slices from young adult PrP null mice is normal, but the amyloid-β oligomer blockade of long-term potentiation is absent. Anti-PrP antibodies prevent amyloid-β-oligomer binding to [PrP.sup.C] and rescue synaptic plasticity in hippocampal slices from oligomeric amyloid-β. Thus, [PrP.sup.C] is a mediator of amyloid-β-oligomer-induced synaptic dysfunction, and [PrP.sup.C]-specific pharmaceuticals may have therapeutic potential for Alzheimer's disease., To characterize amyloid-β-oligomer-binding sites, we synthesized amyloid-β(1-42) peptide conjugated to biotin through the α amino group (biotin-Aβ42), and then denatured the peptide and allowed oligomers to form as described for [...]

Published
2009

18. Lightning Camp.

Author

Gilbert, John W.

Subjects
LIGHTNING Camp (Short story), GILBERT, John
Published
2021

21. Detecting noncompliance

Author

Gilbert, John W.

Subjects
Chronic pain -- Care and treatment, Patient compliance -- Reports, Chronically ill -- Care and treatment -- Reports, Analgesics -- Dosage and administration, Business, Economics, Health care industry
Abstract

I read with interest the article by Mark Crane ['Treating pain without fear,' July 4, 2008]. Mr. Crane points out the importance of regular immunoassay urine drug tests in the [...]

Published
2009

22. Tax law allows property owners to protect their land for the long haul

Author

GILBERT, JOHN W.

Subjects
Easements -- Taxation, Business, Business, regional, Economic Growth and Tax Relief Reconciliation Act of 2001
Abstract

Many people think the recent Economic Growth and Tax Relief Reconciliation Act of 2001 signed into law was all about putting more money in their wallets. But a lesser known [...]

Published
2001

23. Reverse mortgages provide option for funding retirement

Author

GILBERT, JOHN W.

Subjects
Mortgage banks -- Finance, Reverse annuity mortgages -- Finance, Homeowners -- Finance, Business, Business, regional
Abstract

John and Jackie are in their mid-70s; they have lived in the same house for over 25 years and owe approximately $5,000 on their mortgage. Their house is valued at [...]

Published
2001

25. Vestibular Dysfunction in Patients With Chronic Pain or Underlying Neurologic Disorders

Author

Gilbert, John W., primary, Vogt, Manuel, additional, Windsor, Robert E., additional, Mick, Gregory E., additional, Richardson, Gay B., additional, Storey, Benjamin B., additional, Herder, Stephanie L., additional, Ledford, Susan, additional, Abrams, Dee A., additional, Theobald, Mary Katherine, additional, Cunningham, Dana, additional, Kelly, Louise, additional, Herring, Kimberly V., additional, and Maddox, Michael L., additional

Published
2014
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34. Letter to the Editor

Author

Gilbert, John W., primary, Wheeler, Greg R., additional, Mick, Gregory E., additional, and Herder, Stephanie L., additional

Published
2010
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36. Positional MR imaging

Author

Gilbert, John W., primary, Wheeler, Greg R., additional, Mick, Gregory E., additional, Herder, Stephanie L., additional, Richardson, Gay B., additional, Wyttenbach, William H., additional, and Broughton, Patricia G., additional

Published
2010
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39. Patterns of addiction?

Author

Gilbert, John W.

Subjects
Chronic pain -- Care and treatment, Substance abuse -- Care and treatment
Abstract

I read with interest the recent article by Mark Crane ["Treating pain without fear," July 4, 2008]. He points out the importance of regular immunoassay urine drug tests in the [...]

Published
2008

40. Upright MR imaging

Author

Gilbert, John W., primary, Wheeler, Greg R., additional, Mick, Gregory E., additional, Herder, Stephanie L., additional, Richardson, Gay B., additional, Wyttenbach, William H., additional, and Broughton, Patricia, additional

Published
2009
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46. Open Stand-Up MRI

Author

Gilbert, John W., primary, Wheeler, Greg R., additional, Lingreen, Richard A., additional, and Johnson, Robert R., additional

Published
2006
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47. Bull.

Author

Gilbert, John W.

Subjects
BULL (Poem), GILBERT, John
Published
2022

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