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1,526 results on '"Giles, D."'

2. Safety and efficacy of biological agents in the treatment of Systemic Lupus Erythematosus (SLE)

Author

Justin Chan, Giles D. Walters, Prianka Puri, and Simon H. Jiang

Subjects
Systemic lupus erythematosus, Renal lupus, Biologics, Diseases of the musculoskeletal system, RC925-935
Abstract

Abstract Background To determine the safety and efficacy of biological agents used in the treatment of systemic lupus erythematosus (SLE) in adults. Methods Systematic review and meta-analysis following PRISMA guidelines. Data sources MEDLINE (through Pubmed), EMBASE, Cochrane library, Clinicaltrials.gov, Australianclinicaltrials.gov.au, ANZCTR.org.au and WHO International Clinical Trials Registry Platform for studies published from 20 May 2021 and 15 years prior. A grey literature search was performed and completed on 31 May 2021. Study criteria Phase II, III or quasi randomised controlled trials, studies with only cerebral or cutaneous lupus were excluded. Data extraction: Two authors independently screened studies for eligibility, extracted, reviewed data for accuracy, and used the Cochrane tool to assess risk of bias. Results Forty-four studies were identified, consisting of 15 groups of drugs and 25 different biological agents, totalling 16,889 patients. The main outcomes assessed included Systemic Lupus Erythematosus Responder Index (SRI), BILAG-Based Composite Lupus Assessment (BICLA) and combined combined/partial renal remission (CRR/PRR). Four groups of biologics were found to improve outcomes. Anti-interferons: Anifrolumab increased BICLA response and SRI 5 to 8, decreased prednisone dosages, with increased herpes zoster infections, but fewer serious adverse events. Sifalimumab improved SRI but also increased herpes zoster infections. Anti BAFF/BLyS and/or APRIL: Belimumab consistently improved SRI 4, decreased prednisone dosages, increased combined CRR/PRR, and had no adverse safety outcomes. Tabalumab increased SRI 5 at 52 weeks with no steroid sparing effect but was associated with increased infusion related adverse events. Telitacicept improved SRI 4 at 52 weeks, with no increased adverse events, though data was rather sparse. Anti CD-20 monoclonal antibody, Obinutuzumab increased combined CRR/PRR at 1 and 2 years. Anti IL12/23 monoclonal antibody, Ustekinumab, increased SRI 4 to 6, but not BICLA at 24 weeks, with no concerning safety outcomes. Conclusion Multiple biologic agents are shown in high quality studies to have a significant therapeutic impact on outcomes in SLE.

Published
2023
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3. Integrated Mobile System of Two-Wavelength Polarization Micro-pulse Lidar and Photometer for Aerosol Properties Retrievals: Comparisons with Reference Lidar

Author

Sanchez Barrero, M. F., Popovici, I., Goloub, P., Victori, S., Proniewski, L., Hu, Q., Podvin, T., Holben, B., Giles, D., LaRosa, A., Sullivan, John T., editor, Leblanc, Thierry, editor, Tucker, Sara, editor, Demoz, Belay, editor, Eloranta, Edwin, editor, Hostetler, Chris, editor, Ishii, Shoken, editor, Mona, Lucia, editor, Moshary, Fred, editor, Papayannis, Alexandros, editor, and Rupavatharam, Krishna, editor

Published
2023
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4. The first observed stellar occultations by the irregular satellite (Saturn IX) Phoebe and improved rotational period

Author

Gomes-Júnior, A. R., Assafin, M., Braga-Ribas, F., Benedetti-Rossi, G., Morgado, B., Camargo, J. I. B., Vieira-Martins, R., Desmars, J., Sicardy, B., Barry, T., Campbell-White, J., Fernández-Lajús, E., Giles, D., Hanna, W., Hayamizu, T., Hirose, T., De Horta, A., Horvat, R., Hosoi, K., Jehin, E., Kerr, S., Machado, D. I., Mammana, L. A., Maybour, D., Owada, M., Rahvar, S., and Snodgrass, C.

Subjects
Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Solar and Stellar Astrophysics
Abstract

We report six stellar occultations by (Saturn IX) Phoebe, an irregular satellite of Saturn, obtained between mid-2017 and mid-2019. The 2017 July 06 event is the first stellar occultation by an irregular satellite ever observed. The occultation chords were compared to a 3D shape model of the satellite obtained from Cassini observations. The rotation period available in the literature led to a sub-observer point at the moment of the observed occultations where the chords could not fit the 3D model. A procedure was developed to identify the correct sub-observer longitude. It allowed us to obtain the rotation period with improved precision over currently known value from literature. We show that the difference between the observed and the predicted sub-observer longitude suggests two possible solutions for the rotation period. By comparing these values with recently observed rotational light curves and single-chord stellar occultations, we can identify the best solution for Phoebe's rotational period as $9.27365 \pm 0.00002$ h. From the stellar occultations, we also obtained 6 geocentric astrometric positions in the ICRS as realised by the Gaia-DR2 with uncertainties at the 1-mas level., Comment: 13 pages, 12 figures

Published
2019
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6. Prognostic gene expression signature for high-grade serous ovarian cancer

Author

Millstein, J, Budden, T, Goode, EL, Anglesio, MS, Talhouk, A, Intermaggio, MP, Leong, HS, Chen, S, Elatre, W, Gilks, B, Nazeran, T, Volchek, M, Bentley, RC, Wang, C, Chiu, DS, Kommoss, S, Leung, SCY, Senz, J, Lum, A, Chow, V, Sudderuddin, H, Mackenzie, R, George, J, Group, AOCS, Bowtell, D, Chenevix-Trench, G, Green, A, Webb, P, DeFazio, A, Gertig, D, Traficante, N, Fereday, S, Moore, S, Hung, J, Harrap, K, Sadkowsky, T, Pandeya, N, Malt, M, Mellon, A, Robertson, R, Bergh, T Vanden, Jones, M, Mackenzie, P, Maidens, J, Nattress, K, Chiew, YE, Stenlake, A, Sullivan, H, Alexander, B, Ashover, P, Brown, S, Corrish, T, Green, L, Jackman, L, Ferguson, K, Martin, K, Martyn, A, Ranieri, B, White, J, Jayde, V, Mamers, P, Bowes, L, Galletta, L, Giles, D, Hendley, J, Alsop, K, Schmidt, T, Shirley, H, Ball, C, Young, C, Viduka, S, Tran, Hoa, Bilic, Sanela, Glavinas, Lydia, Brooks, Julia, Stuart-Harris, R, Kirsten, F, Rutovitz, J, Clingan, P, Glasgow, A, Proietto, A, Braye, S, Otton, G, Shannon, J, Bonaventura, T, Stewart, J, Begbie, S, Friedlander, M, Bell, D, Baron-Hay, S, Ferrier, AA, Gard, G, Nevell, D, Pavlakis, N, Valmadre, S, Young, B, Camaris, C, Crouch, R, Edwards, L, and Hacker, N

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Genetic Testing, Genetics, Cancer, Ovarian Cancer, Rare Diseases, 4.2 Evaluation of markers and technologies, 4.4 Population screening, Detection, screening and diagnosis, Cystadenocarcinoma, Serous, Female, Humans, Ovarian Neoplasms, Prognosis, Proportional Hazards Models, Survival Analysis, Transcriptome, formalin-fixed paraffin-embedded, gene expression, high-grade serous ovarian cancer, overall survival, prognosis, AOCS Group, Oncology & Carcinogenesis, Clinical sciences, Oncology and carcinogenesis
Abstract

BackgroundMedian overall survival (OS) for women with high-grade serous ovarian cancer (HGSOC) is ∼4 years, yet survival varies widely between patients. There are no well-established, gene expression signatures associated with prognosis. The aim of this study was to develop a robust prognostic signature for OS in patients with HGSOC.Patients and methodsExpression of 513 genes, selected from a meta-analysis of 1455 tumours and other candidates, was measured using NanoString technology from formalin-fixed paraffin-embedded tumour tissue collected from 3769 women with HGSOC from multiple studies. Elastic net regularization for survival analysis was applied to develop a prognostic model for 5-year OS, trained on 2702 tumours from 15 studies and evaluated on an independent set of 1067 tumours from six studies.ResultsExpression levels of 276 genes were associated with OS (false discovery rate < 0.05) in covariate-adjusted single-gene analyses. The top five genes were TAP1, ZFHX4, CXCL9, FBN1 and PTGER3 (P < 0.001). The best performing prognostic signature included 101 genes enriched in pathways with treatment implications. Each gain of one standard deviation in the gene expression score conferred a greater than twofold increase in risk of death [hazard ratio (HR) 2.35, 95% confidence interval (CI) 2.02-2.71; P < 0.001]. Median survival [HR (95% CI)] by gene expression score quintile was 9.5 (8.3 to -), 5.4 (4.6-7.0), 3.8 (3.3-4.6), 3.2 (2.9-3.7) and 2.3 (2.1-2.6) years.ConclusionThe OTTA-SPOT (Ovarian Tumor Tissue Analysis consortium - Stratified Prognosis of Ovarian Tumours) gene expression signature may improve risk stratification in clinical trials by identifying patients who are least likely to achieve 5-year survival. The identified novel genes associated with the outcome may also yield opportunities for the development of targeted therapeutic approaches.

Published
2020

7. A 19 day earth tide measurement with a MEMS gravimeter

Author

Abhinav Prasad, Richard P. Middlemiss, Andreas Noack, Kristian Anastasiou, Steven G. Bramsiepe, Karl Toland, Phoebe R. Utting, Douglas J. Paul, and Giles D. Hammond

Subjects
Medicine, Science
Abstract

Abstract The measurement of tiny variations in local gravity enables the observation of subterranean features. Gravimeters have historically been extremely expensive instruments, but usable gravity measurements have recently been conducted using MEMS (microelectromechanical systems) sensors. Such sensors are cheap to produce, since they rely on the same fabrication techniques used to produce mobile phone accelerometers. A significant challenge in the development of MEMS gravimeters is maintaining stability over long time periods, which is essential for long term monitoring applications. A standard way to demonstrate gravimeter stability and sensitivity is to measure the periodic elastic distortion of the Earth due to tidal forces—the Earth tides. Here, a 19 day measurement of the Earth tides, with a correlation coefficient to the theoretical signal of 0.975, has been presented. This result demonstrates that this MEMS gravimeter is capable of conducting long-term time-lapse gravimetry, a functionality essential for applications such as volcanology.

Published
2022
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9. TLR7 gain-of-function genetic variation causes human lupus

Author

Brown, Grant J., Cañete, Pablo F., Wang, Hao, Medhavy, Arti, Bones, Josiah, Roco, Jonathan A., He, Yuke, Qin, Yuting, Cappello, Jean, Ellyard, Julia I., Bassett, Katharine, Shen, Qian, Burgio, Gaetan, Zhang, Yaoyuan, Turnbull, Cynthia, Meng, Xiangpeng, Wu, Phil, Cho, Eun, Miosge, Lisa A., Andrews, T. Daniel, Field, Matt A., Tvorogov, Denis, Lopez, Angel F., Babon, Jeffrey J., López, Cristina Aparicio, Gónzalez-Murillo, África, Garulo, Daniel Clemente, Pascual, Virginia, Levy, Tess, Mallack, Eric J., Calame, Daniel G., Lotze, Timothy, Lupski, James R., Ding, Huihua, Ullah, Tomalika R., Walters, Giles D., Koina, Mark E., Cook, Matthew C., Shen, Nan, de Lucas Collantes, Carmen, Corry, Ben, Gantier, Michael P., Athanasopoulos, Vicki, and Vinuesa, Carola G.

Published
2022
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10. A High Stability Optical Shadow Sensor with Applications for Precision Accelerometers

Author

Bramsiepe, Steven G, Loomes, David, Middlemiss, Richard P, Paul, Douglas J, and Hammond, Giles D

Subjects
Physics - Instrumentation and Detectors
Abstract

Gravimeters are devices which measure changes in the value of the gravitational acceleration, \textit{g}. This information is used to infer changes in density under the ground allowing the detection of subsurface voids; mineral, oil and gas reserves; and even the detection of the precursors of volcanic eruptions. A micro-electro mechanical system (MEMS) gravimeter has been fabricated completely in silicon allowing the possibility of cost e-effective, lightweight and small gravimeters. To obtain a measurement of gravity, a highly stable displacement measurement of the MEMS is required. This requires the development of a portable electronics system that has a displacement sensitivity of $\leq 2.5$ nm over a period of a day or more. The portable electronics system presented here has a displacement sensitivity $\leq 10$ nm$/\sqrt{\textrm{Hz}}$ ($\leq 0.6$ nm at $1000$ s). The battery power system used a modulated LED for measurements and required temperature control of the system to $\pm$ 2 mK, monitoring of the tilt to $\pm$ 2 $\mu$radians, the storage of measured data and the transmission of the data to an external server., Comment: 8 Pages, 12 figures, 5 equations, currently submitted and under review at IEEE Sensors SIEL

Published
2017
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12. The structure of Chariklo's rings from stellar occultations

Author

Bérard, D., Sicardy, B., Camargo, J. I. B., Desmars, J., Braga-Ribas, F., Ortiz, J. L., Duffard, R., Morales, N., Meza, E., Leiva, R., Benedetti-Rossi, G., Vieira-Martins, R., Gomes-Júnior, A. R., Assafin, M., Colas, F., Dauvergne, J. L., Kervella, P., Lecacheux, J., Maquet, L., Vachier, F., Renner, S., Monard, B., Sickafoose, A. A., Breytenbach, H., Genade, A., Beisker, W., Bath, K. L., Bode, H. J., Backes, M., Ivanov, V. D., Jehin, E., Gillon, M., Manfroid, J., Pollock, J., Tancredi, G., Roland, S., Salvo, R., Vanzi, L., Herald, D., Gault, D., Kerr, S., Pavlov, H., Hill, K. M., Bradshaw, J., Barry, M. A., Cool, A., Lade, B., Cole, A., Broughton, J., Newman, J., Horvart, R., Maybour, D., Giles, D., Davis, L., Paton, R. A., Loader, B., Pennell, A., Jaquiery, P. D., Brillant, S., Selman, F., Dumas, C., Herrera, C., Carraro, G., Monaco, L., Maury, A., Peyrot, A., Teng-Chuen-Yu, J. P., Richichi, A., Irawati, P., De Witt, C., Schoenau, P., Prager, R., Colazo, C., Melia, R., Spagnotto, J., Blain, A., Alonso, S., Román, A, Santos-Sanz, P., Rizos, J. L., Maestre, J. L., and Dunham, D.

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

Two narrow and dense rings (called C1R and C2R) were discovered around the Centaur object (10199) Chariklo during a stellar occultation observed on 2013 June 3. Following this discovery, we planned observations of several occultations by Chariklo's system in order to better characterize the physical properties of the ring and main body. Here, we use 12 successful occulations by Chariklo observed between 2014 and 2016. They provide ring profiles (physical width, opacity, edge structure) and constraints on the radii and pole position. Our new observations are currently consistent with the circular ring solution and pole position, to within the $\pm 3.3$ km formal uncertainty for the ring radii derived by Braga-Ribas et al. The six resolved C1R profiles reveal significant width variations from $\sim 5$ to 7.5 km. The width of the fainter ring C2R is less constrained, and may vary between 0.1 and 1 km. The inner and outer edges of C1R are consistent with infinitely sharp boundaries, with typical upper limits of one kilometer for the transition zone between the ring and empty space. No constraint on the sharpness of C2R's edges is available. A 1$\sigma$ upper limit of $\sim 20$ m is derived for the equivalent width of narrow (physical width <4 km) rings up to distances of 12,000 km, counted in the ring plane.

Published
2017
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13. MyD88 and TLR4 Expression in Epithelial Ovarian Cancer

Author

Block, Matthew S, Vierkant, Robert A, Rambau, Peter F, Winham, Stacey J, Wagner, Philipp, Traficante, Nadia, Tołoczko, Aleksandra, Tiezzi, Daniel G, Taran, Florin Andrei, Sinn, Peter, Sieh, Weiva, Sharma, Raghwa, Rothstein, Joseph H, Ramón y Cajal, Teresa, Paz-Ares, Luis, Oszurek, Oleg, Orsulic, Sandra, Ness, Roberta B, Nelson, Gregg, Modugno, Francesmary, Menkiszak, Janusz, McGuire, Valerie, McCauley, Bryan M, Mack, Marie, Lubiński, Jan, Longacre, Teri A, Li, Zheng, Lester, Jenny, Kennedy, Catherine J, Kalli, Kimberly R, Jung, Audrey Y, Johnatty, Sharon E, Jimenez-Linan, Mercedes, Jensen, Allan, Intermaggio, Maria P, Hung, Jillian, Herpel, Esther, Hernandez, Brenda Y, Hartkopf, Andreas D, Harnett, Paul R, Ghatage, Prafull, García-Bueno, José M, Gao, Bo, Fereday, Sian, Eilber, Ursula, Edwards, Robert P, de Sousa, Christiani B, de Andrade, Jurandyr M, Chudecka-Głaz, Anita, Chenevix-Trench, Georgia, Cazorla, Alicia, Brucker, Sara Y, Group, Australian Ovarian Cancer Study, Bowtell, D, Chenevix-Trench, G, Green, A, Webb, P, DeFazio, A, Gertig, D, Traficante, N, Fereday, S, Moore, S, Hung, J, Harrap, K, Sadkowsky, T, Pandeya, N, Malt, M, Mellon, A, Robertson, R, Bergh, T Vanden, Jones, M, Mackenzie, P, Maidens, J, Nattress, K, Chiew, YE, Stenlake, A, Sullivan, H, Alexander, B, Ashover, P, Brown, S, Corrish, T, Green, L, Jackman, L, Ferguson, K, Martin, K, Martyn, A, Ranieri, B, White, J, Jayde, V, Mamers, P, Bowes, L, Galletta, L, Giles, D, Hendley, J, Alsop, K, Schmidt, T, Shirley, H, Ball, C, Young, C, and Viduka, S

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Clinical Research, Cancer, Rare Diseases, Ovarian Cancer, Adult, Aged, Biomarkers, Tumor, Carcinoma, Ovarian Epithelial, Female, Humans, Immunohistochemistry, Middle Aged, Myeloid Differentiation Factor 88, Ovarian Neoplasms, Survival Analysis, Tissue Array Analysis, Toll-Like Receptor 4, Australian Ovarian Cancer Study Group, Medical and Health Sciences, Biomedical and clinical sciences
Abstract

ObjectiveTo evaluate myeloid differentiation primary response gene 88 (MyD88) and Toll-like receptor 4 (TLR4) expression in relation to clinical features of epithelial ovarian cancer, histologic subtypes, and overall survival.Patients and methodsWe conducted centralized immunohistochemical staining, semi-quantitative scoring, and survival analysis in 5263 patients participating in the Ovarian Tumor Tissue Analysis consortium. Patients were diagnosed between January 1, 1978, and December 31, 2014, including 2865 high-grade serous ovarian carcinomas (HGSOCs), with more than 12,000 person-years of follow-up time. Tissue microarrays were stained for MyD88 and TLR4, and staining intensity was classified using a 2-tiered system for each marker (weak vs strong).ResultsExpression of MyD88 and TLR4 was similar in all histotypes except clear cell ovarian cancer, which showed reduced expression compared with other histotypes (P

Published
2018

14. Deletions in VANGL1 are a risk factor for antibody-mediated kidney disease

Author

Jiang, Simon H., Mercan, Sevcan, Papa, Ilenia, Moldovan, Max, Walters, Giles D., Koina, Mark, Fadia, Mitali, Stanley, Maurice, Lea-Henry, Tom, Cook, Amelia, Ellyard, Julia, McMorran, Brendan, Sundaram, Madhivanan, Thomson, Russell, Canete, Pablo F., Hoy, Wendy, Hutton, Holly, Srivastava, Monika, McKeon, Kathryn, de la Rúa Figueroa, Iñigo, Cervera, Ricard, Faria, Raquel, D’Alfonso, Sandra, Gatto, Mariele, Athanasopoulos, Vicki, Field, Matthew, Mathews, John, Cho, Eun, Andrews, Thomas D., Kitching, A. Richard, Cook, Matthew C., Riquelme, Marta Alarcon, Bahlo, Melanie, and Vinuesa, Carola G.

Published
2021
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15. Rare SH2B3 coding variants in lupus patients impair B cell tolerance and predispose to autoimmunity

Author

Zhang, Yaoyuan, primary, Morris, Rhiannon, additional, Brown, Grant J., additional, Lorenzo, Ayla May D., additional, Meng, Xiangpeng, additional, Kershaw, Nadia J., additional, Kiridena, Pamudika, additional, Burgio, Gaétan, additional, Gross, Simon, additional, Cappello, Jean Y., additional, Shen, Qian, additional, Wang, Hao, additional, Turnbull, Cynthia, additional, Lea-Henry, Tom, additional, Stanley, Maurice, additional, Yu, Zhijia, additional, Ballard, Fiona D., additional, Chuah, Aaron, additional, Lee, James C., additional, Hatch, Ann-Maree, additional, Enders, Anselm, additional, Masters, Seth L., additional, Headley, Alexander P., additional, Trnka, Peter, additional, Mallon, Dominic, additional, Fletcher, Jeffery T., additional, Walters, Giles D., additional, Šestan, Mario, additional, Jelušić, Marija, additional, Cook, Matthew C., additional, Athanasopoulos, Vicki, additional, Fulcher, David A., additional, Babon, Jeffrey J., additional, Vinuesa, Carola G., additional, and Ellyard, Julia I., additional

Published
2024
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16. Pluto's atmosphere from the 29 June 2015 ground-based stellar occultation at the time of the New Horizons flyby

Author

Sicardy, B., Talbot, J., Meza, E., Camargo, J. I. B., Desmars, J., Gault, D., Herald, D., Kerr, S., Pavlov, H., Braga-Ribas, F., Assafin, M., Benedetti-Rossi, G., Dias-Oliveira, A., Ramos-Gomes-Jr., A., Vieira-Martins, R., Berard, D., Kervella, P., Lecacheux, J., Lellouch, E., Beisker, W., Dunham, D., Jelinek, M., Duffard, R., Ortiz, J. L., Castro-Tirado, A. J., Cunniffe, R., Querel, R., Yock, P. A., Cole, A. A., Giles, A. B., Hill, K. M., Beaulieu, J. P., Harnisch, M., Jansen, R., Pennell, A., Todd, S., Allen, W. H., Graham, P. B., Loader, B., McKay, G., Milner, J., Parker, S., Barry, M. A., Bradshaw, J., Broughton, J., Davis, L., Devillepoix, H., Drummond, J., Field, L., Forbes, M., Giles, D., Glassey, R., Groom, R., Hooper, D., Horvat, R., Hudson, G., Idaczyk, R., Jenke, D., Lade, B., Newman, J., Nosworthy, P., Purcell, P., Skilton, P. F., Streamer, M., Unwin, M., Watanabe, H., White, G. L., and Watson, D.

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

We present results from a multi-chord Pluto stellar occultation observed on 29 June 2015 from New Zealand and Australia. This occurred only two weeks before the NASA New Horizons flyby of the Pluto system and serves as a useful comparison between ground-based and space results. We find that Pluto's atmosphere is still expanding, with a significant pressure increase of 5$\pm$2\% since 2013 and a factor of almost three since 1988. This trend rules out, as of today, an atmospheric collapse associated with Pluto's recession from the Sun. A central flash, a rare occurrence, was observed from several sites in New Zealand. The flash shape and amplitude are compatible with a spherical and transparent atmospheric layer of roughly 3~km in thickness whose base lies at about 4~km above Pluto's surface, and where an average thermal gradient of about 5 K~km$^{-1}$ prevails. We discuss the possibility that small departures between the observed and modeled flash are caused by local topographic features (mountains) along Pluto's limb that block the stellar light. Finally, using two possible temperature profiles, and extrapolating our pressure profile from our deepest accessible level down to the surface, we obtain a possible range of 11.9-13.7~$\mu$bar for the surface pressure., Comment: 16 pages, 2 tables, 3 figures

Published
2016
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17. Refined cut-off for TP53 immunohistochemistry improves prediction of TP53 mutation status in ovarian mucinous tumors: implications for outcome analyses

Author

Kang, Eun Young, Cheasley, Dane, LePage, Cecile, Wakefield, Matthew J., da Cunha Torres, Michelle, Rowley, Simone, Salazar, Carolina, Xing, Zhongyue, Allan, Prue, Bowtell, David D.L., Mes-Masson, Anne-Marie, Provencher, Diane M., Rahimi, Kurosh, Kelemen, Linda E., Fasching, Peter A., Doherty, Jennifer A., Goodman, Marc T., Goode, Ellen L., Deen, Suha, Pharoah, Paul D.P., Brenton, James D., Sieh, Weiva, Mateoiu, Constantina, Sundfeldt, Karin, Cook, Linda S., Le, Nhu D., Anglesio, Michael S., Gilks, C. Blake, Huntsman, David G., Kennedy, Catherine J., Traficante, Nadia, Bowtell, D., Chenevix-Trench, G., Green, A., Webb, P., DeFazio, A., Gertig, D., Traficante, N., Fereday, S., Moore, S., Hung, J., Harrap, K., Sadkowsky, T., Pandeya, N., Malt, M., Mellon, A., Robertson, R., Bergh, T. Vanden, Jones, M., Mackenzie, P., Maidens, J., Nattress, K., Chiew, Y.E., Stenlake, A., Sullivan, H., Alexander, B., Ashover, P., Brown, S., Corrish, T., Green, L., Jackman, L., Ferguson, K., Martin, K., Martyn, A., Ranieri, B., White, J., Jayde, V., Mamers, P., Bowes, L., Galletta, L., Giles, D., Hendley, J., Alsop, K., Schmidt, T., Shirley, H., Ball, C., Young, C., Viduka, S., Tran, Hoa, Bilic, Sanela, Glavinas, Lydia, Brooks, Julia, Stuart-Harris, R., Kirsten, F., Rutovitz, J., Clingan, P., Glasgow, A., Proietto, A., Braye, S., Otton, G., Shannon, J., Bonaventura, T., Stewart, J., Begbie, S., Friedlander, M., Bell, D., Baron-Hay, S., Ferrier, A., Gard, G., Nevell, D., Pavlakis, N., Valmadre, S., Young, B., Camaris, C., Crouch, R., Edwards, L., Hacker, N., Marsden, D., Robertson, G., Beale, P., Beith, J., Carter, J., Dalrymple, C., Houghton, R., Russell, P., Links, M., Grygiel, J., Hill, J., Brand, A., Byth, K., Jaworski, R., Harnett, P., Sharma, R., Wain, G., Ward, B., Papadimos, D., Crandon, A., Cummings, M., Horwood, K., Obermair, A., Perrin, L., Wyld, D., Nicklin, J., Davy, M., Oehler, M.K., Hall, C., Dodd, T., Healy, T., Pittman, K., Henderson, D., Miller, J., Pierdes, J., Blomfield, P., Challis, D., McIntosh, R., Parker, A., Brown, B., Rome, R., Allen, D., Grant, P., Hyde, S., Laurie, R., Robbie, M., Healy, D., Jobling, T., Manolitsas, T., McNealage, J., Rogers, P., Susil, B., Sumithran, E., Simpson, I., Phillips, K., Rischin, D., Fox, S., Johnson, D., Lade, S., Loughrey, M., O'Callaghan, N., Murray, W., Waring, P., Billson, V., Pyman, J., Neesham, D., Quinn, M., Underhill, C., Bell, R., Ng, L.F., Blum, R., Ganju, V., Hammond, I., Leung, Y., McCartney, A., Buck, M., Haviv, I., Purdie, D., Whiteman, D., Zeps, N., DeFazio, Anna, Kaufmann, Scott, Churchman, Michael, Gourley, Charlie, Stephens, Andrew N., Meagher, Nicola S., Ramus, Susan J., Antill, Yoland C., Campbell, Ian, Scott, Clare L., Köbel, Martin, Gorringe, Kylie L., Ryland, Georgina L., Allan, Prue E., Alsop, Kathryn, Ananda, Sumitra, Au-Yeung, George, Böhm, Maret, Brand, Alison, Chenevix-Trench, Georgia, Christie, Michael, Chiew, Yoke-Eng, Dudley, Rhiannon, Fairweather, Nicole, Fereday, Sian, Fox, Stephen B., Hacker, Neville F., Hadley, Alison M., Hendley, Joy, Ho, Gwo-Yaw, Hunter, Sally M., Jobling, Tom W., Kalli, Kimberly R., Kaufmann, Scott H., Le Page, Cecile, McNally, Orla M., McAlpine, Jessica N., Mileshkin, Linda, Pyman, Jan, Samimi, Goli, Sharma, Ragwha, and Campbell, Ian G.

Published
2021
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19. Postoperative Outcomes Associated With Procedural Sedation Conducted by Physician and Nonphysician Anesthesia Providers: Findings From the Prospective, Observational African Surgical Outcomes Study

Author

van der Merwe, Freliza, Vickery, Nicola J., Kluyts, Hyla-Louise, Yang, Dongsheng, Han, Yanyan, Munlemvo, Dolly M., Ashebir, Daniel Z., Mbwele, Bernard, Forget, Patrice, Basenero, Apollo, Youssouf, Coulibaly, Antwi-Kusi, Akwasi, Ndonga, Andrew K., Ngumi, Zipporah W. W., Elkhogia, Abdulaziz, Omigbodun, Akinyinka O., Tumukunde, Janat, Madzimbamuto, Farai D., Gobin, Veekash, Mehyaoui, Ryad, Samateh, Ahmadou L., du Toit, Leon, Madiba, Thandinkosi E., Pearse, Rupert M., Biccard, Bruce M., Abadagan, H., Abbas, N., Abdelatif, A. I., Abdoulaye, T., Abd-rouf, A., Abduljalil, A., Abdulrahman, A., Abdurazig, S., Abokris, A., Abozaid, W., Abugassa, S. O. A., Abuhdema, F., Abujanah, S. A., Abusamra, R., Abushnaf, A., Abusnina, S. A., Abuzalout, T. S., Ackermann, H. M., Adamu, Y. B., Addanfour, A., Adeleke, D. M., Adigun, T. A., Adisa, A. O., Adjignon, S. V., Adu-Aryee, N. A., Afolabi, B. B., Agaba, A. F. X., Agaba, P. K. A., Aghadi, K., Agilla, H., Ahmed, B., Ahmed, El.-Z., Ahmed, Al.-J., Ahmed, M., Ahossi, R., Aji, S. A., Akanyun, S., Akhideno, I., Akhter, M., Akinyemi, O. A., Akkari, M., Akodjenou, J., al Shams, E. S., Alagbe-Briggs, O. T., Alakkari, E. A., Alalem, R. B., Alashhab, M., Alatise, O. I., Alatresh, A., Alayeb, M. S. I., Albakosh, B. A., Albert, F., Alberts, A. N. J. D., Aldarrat, A. D., Alfari, A., Alfetore, A., Algbali, M., Algddar, A., Algedar, H. A., Alghafoud, I. A., Alghazali, A., Alhajj, M., Alhendery, A., Alhoty, F. F. H., Ali, A., Ali, Y. A., Ali, A., Alioune, B. S., Alkassem, M. A., Alkchr, M. A., Alkesa, T. S., Alkilani, A., Alkobty, F., Allaye, T., Alleesaib, S. B. M., Alli, A., Allopi, K., Allorto, N. L., Almajbery, A., Almesmary, R., Almisslati, S. H. A., Almoraid, F., Alobeidi, H., Alomami, M. A., Alphonsus, C. S., Alqawi, O. A., Alraheem, A. A., Alsabri, S. A., Alsayed, A., Alsellabi, B., Al-Serksi, M., Alshareef, M. S. A., Altagazi, A. A., Aluvale, J. S., Alwahedi, H. W., Alzahra, E. A., Alzarouk, M. A., Al-Zubaidy, K., Amadou, M., Amadou, M., Amanor-Boadu, S. D., Amer, Al.-A., Amisi, B. T., Amuthenu, M. A., Anabah, T. W. A., Anani, F., Anderson, P. G. R., Andriamampionona, A. G. B., Andrianina, L., Anele, A., Angelin, R., Anjar, N., Antùnez, O., Anyanwu, L. J. C., Aribi, A. A., Arowolo, O. A., Arrey, O., Assefa, S. B., Assoum, G., Athanse, V., Athombo, J. S., Atiku, M., Atito-Narh, E., Atomabe, A., Attia, A., Aungraheeta, M., Aurélia, D. M. A., Ayandipo, O. O., Ayebale, A. E. T., Azzaidey, H. M. Z., Babajee, N. B., Badi, H. B., Badianga, E. K., Baghni, R. B., Bahta, M. T., Bai, M., Baitchu, Y., Baloyi, A. M., Bamuza, K. A., Bamuza, M. I., Bangure, L., Bankole, O. B., Barongo, M. L., Barow, M. M., Bashiya, L., Basson, C. H., Bechan, S., Belhaj, S., Ben Mansour, M. M., Benali, D., Benamour, A. S. B., Berhe, A., Bertie, J. D., Bester, J. J. A., Bester, M., Bezuidenhout, J. D., Bhagwan, K., Bhagwandass, D. R., Bhat, K. A. P., Bhuiyan, M. M. Z. U., Bigirimana, F., Bikuelo, C. J., Bilby, B. E., Bingidimi, S. S., Bischof, K. E., Bishop, D. G., Bitta, C., Bittaye, M., Biyase, T., Blake, C. A., Blignaut, E., Blignaut, F., Tanjong, B. N., Bogoslovskiy, A., Boloko, P. M., Boodhun, S. K. B., Bori, I., Boufas, F., Brand, M., Brouckaert, N. T., Bruwer, J. D., Buccimazza, I., Bula Bula, I. M., Bulamba, F., Businge, B. C., Bwambale, Y. B., Cacala, S. R. C., Cadersa, M. A., Cairns, C., Carlos, F., Casey, M. E., Castro, A. C., Chabayanzara, N. D., Chaibou, M. S., Chaibva, T. N. O., Chakafa, N. K., Chalo, C., Changfoot, C., Chari, M. C., Chelbi, L., Chibanda, J. T., Chifamba, H. N., Chikh, N., Chikumba, E., Chimberengwa, P., Chirengwa, J., Chitungo, F. M., Chiwanga, M. C., Chokoe, M. M., Chokwe, T. M., Chrirangi, B., Christian, M., Church, B., Cisekedi, J. C., Clegg-Lamptey, J. N., Cloete, E., Coltman, M., Conradie, W., Constance, N., Coulibaly, Y., Cronje, L., Da Silva, M. A., Daddy, H., Dahim, L., Daliri, D., Dambaki, M. S., Dasrath, A., Davids, J. G., Davies, G. L., De Lange, J. T., de Wet, J. B., Dedekind, B., Degaulle, M. A., Dehal, V., Deka, P. D., Delinikaytis, S., Desalu, I. S., Dewanou, H., Deye, M. B. M., Dhege, C., Diale, B. S. G., Dibwe, D. F., Diedericks, B. J. S., Dippenaar, J. M., Dippenaar, L., Diyoyo, M. P., Djessouho, E., Dlamini, S. N., Dodiyi-Manuel, A., Dokolwana, B. A., Domoyyeri, D. P., Drummond, L. W., du Plessis, D. E., du Plessis, W. M., du Preez, L. J., Dube, K., Dube, N. Z., Dullab, K. D., Duvenhage, R., Echem, R. C., Edaigbini, S. A., Egote, A. K., Ehouni, A., Ekwen, G., Ekwunife, N. C., El Hensheri, M., Elfaghi, I. E., Elfagieh, M. A., Elfallah, S., Elfiky, M., Elgelany, S., Elghallal, A. M., Elghandouri, M. G., Elghazal, Z. S., Elghobashy, A. M., Elharati, F. T., Elkhwildi, R. M., Ellis, S., Elmadani, L., Elmadany, H. B., Elmehdawi, H., Elmgadmi, A., Eloi, H., Elrafifi, D., Elsaadi, G., Elsaity, R. B., Elshikhy, A., Eltaguri, M., Elwerfelli, A., Elyasir, I. E., Elzoway, A. Z., Elzufri, A. M., Enendu, E. O., Enicker, B. C., Enwerem, E. O., Esayas, R., Eshtiwi, M., Eshwehdi, A. A., Esterhuizen, J. L., Esterhuizen, T. M., Etuk, E. B., Eurayet, O., Eyelade, O. R., Fanjandrainy, R. F., Fanou, L., Farina, Z., Fawzy, M., Feituri, A., Fernandes, N. L., Ford, L. M., François, T., Freeman, T., Freeman, Y. B. M., Gacii, V. M., Gadi, B., Gagara, M., Gakenia, A., Gallou, P. D., Gama, G. G. N., Gamal, M. G., Gandy, Y. G., Ganesh, A., Gangaly, D., Garcia, M., Gatheru, A. P., Gaya, S. S. D., Gbéhadé, O., Gerbel, G., Ghnain, A., Gigabhoy, R., Giles, D. G., Girmaye, G. T., Gitau, S., Githae, B., Gitta, S., Goga, R., Gomati, A. A. G., Gonzalez, M. E., Gopall, J., Gordon, C. S., Gorelyk, O., Gova, M., Govender, K., Govender, P., Govender, S., Govindasamy, V., Green-Harris, J. T. K., Greenwood, M. B., Grey-Johnson, S. V., Grobbelaar, M., Groenewald, M. A., Grünewald, K. K., Guegni, A., Guenane, M., Gueye, S., Guezo, M., Gunguwo, T., Gweder, M. G., Gwila, M., Habimana, L., Hadecon, R., Hadia, E., Hamadi, L., Hammouda, M., Hampton, M. I., Hanta, R., Hardcastle, T. C., Hariniaina, J. A., Hariparsad, S., Harissou, A. H., Harrichandparsad, R., Hasan, S. H. A., Hashmi, H. B., Hayes, M. P., Hdud, A., Hebli, S. H., Heerah, H. M. S. N., Hersi, S., Hery, A. H., Hewitt-Smith, A., Hlako, T. C., Hodges, S. C. H., Hodgson, R. E., Hokoma, M., Holder, H., Holford, E. B., Horugavye, E., Houston, C., Hove, M., Hugo, D., Human, C. M., Hurri, H., Huwidi, O., Ibrahim, A. I., Ibrahim, T., Idowu, O. K., Igaga, I. E., Igenge, J., Ihezie, O., Ikandi, K., Ike, I. A. R., Ikuku, J. J. N., Ilbarasi, M. N., Ilunga, I. B. B., Ilunga, J. P. M., Imbangu, N. A. V., Imessaoudene, Z., Imposo, D. H., Iraya, A. M., Isaacs, M., Isiguzo, M., Issoufou, A., Izquirdo, P., Jaber, A., Jaganath, U. V., Jallow, C. S., Jamabo, S., Jamal, Z. S., Janneh, L., Jannetjies, M. J., Jasim, I., Jaworska, M. A. J., Jay Narain, S., Jermi, K., Jimoh, R., Jithoo, S., Johnson, M., Joomye, S., Judicael, R. M., Judicaël, M., Juwid, A., Jwambi, L. P., Kabango, R., Kabangu, J. K., Kabatoro, D. K., Kabongo, A. N., Kabongo, K., Kabongo, L. T., Kabongo, M. D., Kady, N., Kafu, S., Kaggya, M., Kaholongo, B. N. K., Kairuki, P. C. K., Kakololo, S. I., Kakudji, K., Kalisa, A., Kalisa, R., Kalufwelu, M. R., Kalume, S., Kamanda, R. J., Kangili, M. K., Kanoun, Kapesa, H., Kapp, P., Karanja, J. K., Karar, M., Kariuki, K., Kaseke, K., Kashuupulwa, P. N. K., Kasongo, K. J. P., Kassa, S. K., Kateregga, G. K., Kathrada, M. I. S., Katompwa, P. M., Katsukunya, L., Kavuma, Khalfallah, K. A. M., Khamajeet, A., Khetrish, Kibandwa, S. B., Kibochi, W., Kilembe, A. M., Kintu, A. K., Kipng’etich, B., Kiprop, B., Kissoon, V. M. K., Kisten, T. K., Kiwanuka, J. K., Knox, M. E. K., Koledale, A. K., Koller, V. L., Kolotsi, M. A., Kongolo, M., Konwuoh, N. D., Koperski, W. J., Koraz, M. Y. K., Kornilov, A. A., Koto, M. Z., Kransingh, S., Krick, D., Kruger, S., Kruse, C., Kuhn, W., Kuhn, W. P., Kukembila, A. M., Kule, K. L., Kumar, M., Kusel, B. S., Kusweje, V. K., Kuteesa, K. J., Kutor, Y. Y., Labib, M. A., Laksari, M., Lanos, F., Lawal, T. A., Le Manach, Y., Lee, C., Lekoloane, R. M., Lelo, S. N., Lerutla, B., Lerutla, M. T., Levin, A. I., Likongo, T. B., Limbajee, M. L., Linyama, D. M., Lionnet, C., Liwani, M. M., Loots, E., Lopez, A. G., Lubamba, C. L. C., Lumbala, K. F., Lumbamba, A. J. M., Lumona, John, Lushima, R. F., Luthuli, L., Luweesi, H. L., Lyimo, T. S. K., Maakamedi, H. M., Mabaso, B. M., Mabina, M., Maboya, M. E., Macharia, I., Macheka, A. M., Machowski, A. Z., Madsen, A. S. M., Madzivhe, L. J., Mafafo, S. C., Maghrabi, M., Mahamane, D. D., Maharaj, A., Maharaj, A., Maharaj, A. D., Mahmud, M. R., Mahoko, M., Mahomedy, N. A., Mahomva, O., Mahureva, T. M., Maila, R. K., Maimane, D. M., Maimbo, M., Maina, S. N., Maiwald, D. A., Maiyalagan, M. D., Majola, N., Makgofa, N., Makhanya, V., Makhaye, W. P., Makhlouf, N. M., Makhoba, S., Makopa, E. K., Makori, O., Makupe, A. M., Makwela, M. A., Malefo, M. E., Malongwe, S. M., Maluleke, D. M., Maluleke, M. R., Mamadou, K. T., Mamaleka, M. P., Mampangula, Y., Mamy, R. M., Mananjara, M. N. R., Mandarry, M. T. M., Mangoo, D. M., Manirimbere, C., Manneh, A., Mansour, A., Mansour, I., Manvinder, M., Manyere, D. V., Manzini, V. T., Manzombi, J. K., Mapanda, P. M., Marais, L. C., Maranga, O., Maritz, J. P. B., Mariwa, F. K., Masela, R. S., Mashamba, M. M., Mashava, D. M., Mashile, M. V., Mashoko, E., Masia, O. R., Masipa, J. N., Masiyambiri, A. T. M., Matenchi, M. W., Mathangani, W., Mathe, R. C., Matola, C. Y., Matondo, P. M., Matos-Puig, R., Matoug, F. F. H., Matubatuba, J. T., Mavesere, H. P., Mavhungu, R., Maweni, S., Mawire, C. J. M., Mawisa, T., Mayeza, S., Mbadi, R., Mbayabu, M., Mbewe, N., Mbombo, W. D., Mbuyi, T., Mbuyi, W. M. S., Mbuyisa, M. W., Menkiti, I. D., Mesarieki, L. V. M., Metali, A., Mewanou, S., Mgonja, L., Mgoqo, N., Mhatu, S., Mhlari, T. M., Miima, S., Milod, I. M., Minani, P., Mitema, F., Mlotshwa, A., Mmasi, J. E., Mniki, T., Mofikoya, B. O., Mogale, J. O., Mohamed, A., Mohamed, A., Mohamed, A., Mohamed, S., Mohamed, S., Mohamed, T. S., Mohamed, A., Mohamed, A., Mohamed, A. M., Mohamed, P., Mohammed, I., Mohammed, F. A. M., Mohammed, M., Mohammed, N. M., Mohlala, M. P., Mokretar, R., Molokoane, F. M., Mongwe, K. N., Montenegro, L., Montwedi, O. D., Moodie, Q. K., Moopanar, M., Morapedi, M., Morulana, T. G., Moses, V. L., Mossy, P., Mostafa, H., Motilall, S. R., Motloutsi, S. P., Moussa, K., Moutari, M., Moyo, O. M., Mphephu, P. E., Mrara, B., Msadabwe, C., Mtongwe, V. M., Mubeya, F. K., Muchiri, K., Mugambi, J., Muguti, G. I. M., Muhammad, A. B., Mukama, I. F., Mukenga, M. M., Mukinda, F. K., Mukuna, P. M., Mungherera, A. R. W., Munyaradzi, T. W., Munyika, A. A., Muriithi, J. M., Muroonga, M. P., Murray, R., Mushangwe, V. K., Mushaninga, M., Musiba, V. E. M., Musowoya, J. M., Mutahi, S., Mutasiigwa, M. G. H., Mutizira, G., Muturi, A., Muzenda, T., Mvwala, K. R., Mvwama, N. M., Mwale, A., Mwaluka, C. N., Mwamba, J. D., Mwanga, H. A. M., Mwangi, C. M., Mwansa, S., Mwenda, V., Mwepu, I. M., Mwiti, T. M., Mzezewa, S. Z., Nabela, L., Nabukenya, M. T. N., Nabulindo, S. M., Naicker, K., Naidoo, D., Naidoo, L., Naidoo, L. C., Naidoo, N., Naidoo, R., Naidoo, R. D., Naidoo, S., Naidoo, T. D., Naidu, T. K., Najat, N. Z., Najm, Y., Nakandungile, F., Nakangombe, P., Namata, C. N., Namegabe, E. S., Nansook, A., Nansubuga, N. P., Nantulu, C., Nascimento, R., Naude, G. T., Nchimunya, H., Ndaie, M. A., Ndarukwa, P. N., Ndasi, H., Ndayisaba, G., Ndegwa, D., Ndikumana, R., Ndung’u, C., Neil, M. C., Nel, M. S., Neluheni, E. V., Nesengani, D. S., Nesengani, N. T., Netshimboni, L. E., Ngalala, A. M., Ngari, B. M., Ngari, N. B. M., Ngatia, E., Ngcobo, G. K., Ngcobo, T. S., Ngorora, D., Ngouane, D., Ngugi, K., Nibe, Z., Ninise, E., Niyondiko, J. C., Njenga, P. W., Njenga, M. N., Njoroge, M., Njoroge, S., Njuguna, W., Njuki, P. N., Nkesha, T., Nkuebe, T. N., Nkuliyingoma, N. P., Nkunjana, M., Nkwabi, E., Nkwine, R. N., Nnaji, C., Notoane, I., Nsalamba, S., Ntlhe, L. M., Ntoto, C., Ntueba, B., Nyassi, M. T., Nyatela-Akinrinmade, Z., Nyawanda, H. O., Nyokabi, N. N., Nziene, V. N., Obadiah, S., Ochieng, O. J. P., Odia, P. K., Oduor, O. E. O., Ogboli-Nwasor, E. O., Ogendo, S. W. O., Ogunbode, O., Ogundiran, T. O., Ogutu, O., Ojewola, R. W., Ojujo, M., Ojuka, D. O., Okelo, O. S., Okiya, S., Okonu, N., Olang, P. R., Omoding, S., Omoshoro-Jones, J., Onyango, R., Onyegbule, A., Orjiako, O., Osazuwa, M. O., Oscar, K., Osinaike, B. B., Osinowo, A. O., Othin, O. M., Otman, F. F. H., Otokwala, J., Ouanes, F., Oumar, O., Ousseini, A. O., Padayachee, S., Pahlana, S. M., Pansegrouw, J., Paruk, F. P., Patel, M. B., Patel, U., Patience, A. P., Pembe, J. D., Pengemale, G. N., Perez, N., Perez, M. F. A., Peter, A. M., Phaff, M., Pheeha, R. M., Pienaar, B. H., Pillay, V., Pilusa, K. A., Pochana, M. P., Polishchuk, O., Porrill, O. S., Post, E. F., Prosper, A., Pupyshev, M., Rabemazava, A., Rabiou, M. S., Rademan, L., Rademeyer, M., Raherison, R. A. R., Rajah, F. R., Rajcoomar, M. S. R., Rakhda, Z., Rakotoarijaona, A. H. R., Rakotoarisoa, A. H. N., Rakotoarison, S. R., Rakotoarison, R. R., Ramadan, L., Ramananasoa, M. L. R., Rambau, M., Ramchurn, T. P. R., Ramilson, H. E., Ramjee, R. J., Ramnarain, H., Ramos, R., Rampai, T. J., Ramphal, S. R., Ramsamy, T., Ramuntshi, R., Randolph, R., Randriambololona, D. M. A., Ras, W. A. P., Rasolondraibe, R. A. F., Rasolonjatovo, J. D. L. C., Rautenbach, R. M., Ray, S., Rayne, S. R., Razanakoto, F. A. R., Reddy, S. R., Reed, A. R., Rian, J. R., Rija, F. R., Rink, B., Robelie, A. T., Roberts, C. A., Rocher, A. G. L., Rocher, S., Rodseth, R. N., Rois, I., Rois, W., Rokhsi, S., Roos, J., Rorke, N. F., Roura, H., Rousseau, F. J., Rousseau, N., Royas, L., Roytowski, D., Rungan, D., Rwehumbiza, S. S. R., Ryabchiy, B. B., Ryndine, V., Saaiman, C. R., Sabwa, H. K., Sadat, S., Saed, S. S., Salaheddin, E., Salaou, H., Saleh, M., Salisu-Kabara, H. M., Sama, H. D., Samateh, A. L., Sam-Awortwi, W., Jnr, Samuel, N., Sanduku, D. K., Sani, C. M., Sanyang, L. N., Sarah, H. N., Sarkin-Pawa, A., Sathiram, R., Saurombe, T., Schutte, H., Sebei, M. P., Sedekounou, M. D., Segooa, M. P., Semenya, E. M., Semo, B. O., Sendagire, C. S., Senoga, S. A., Senusi, F. S., Serdyn, T., Seshibe, M. D., Shah, G. B., Shamamba, R., Shambare, C. S., Shangase, T. N., Shanin, S. H., Shefren, I. E., Sheshe, A. A., Shittu, O. B., Shkirban, A. S., Sholadoye, T., Shubba, A., Sigcu, N., Sihope, S. E., Sikazwe, D. S., Sikombe, B. S., Simaga Abdoul, K., Simo, W. A. G., Singata, K., Singh, A. S., Singh, S., Singh, U., Sinoamadi, V., Sipuka, N., Sithole, N. L. M., Sitima, S., Skinner, D. L., Skinner, G. C., Smith, O. I., Smits, C. A. G., Sofia, M. S. I., Sogoba, G., Sohoub, A., Sookun, S. S., Sosinska, O., Souhe, R., Souley, G., Souleymane, T., Spicer, J. M., Spijkerman, S., Steinhaus, H., Steyn, A., Steyn, G., Steyn, H. C., Stoltenkamp, H. L., Stroyer, S., Swaleh, A., Swayeb, E., Szpytko, A. J., Taiwo, N. A., Tarhuni, A., Tarloff, D., Tchaou, B., Tchegnonsi, C., Tchoupa, M., Teeka, M. O., Thakoor, B., Theunissen, M. M., Thomas, B. P., Thomas, M. B., Thotharam, A., Tobiko, O., Torborg, A. M., Tshisekedi, S. M., Tshisola, S. K., Tshitangano, R., Tshivhula, F., Tshuma, H. T., Tun, M., Udo, I. A., Uhuebor, D. I., Umeh, K. U., Usenbo, A. O., Uwiteyimbabazi, Jd. D., Van der Merwe, D. J., van der Walt, J. E., van Dyk, D., Van Dyk, J. G., van Niekerk, J. J. S., van Wyk, S., van Zyl, H. A., Veerasamy, B., Venter, P. J., Vermeulen, A. J., Villarreal, R., Visser, J., Visser, L., Voigt, M., von Rahden, R. P., Wafa, A., Wafula, A., Wambugu, P. K., Waryoba, P., Waweru, E. N., Weideman, M., Wise, R. D., Wynne, E. E., Yahya, A. I., Yahya, A. A., Yahya, R., Yakubu, Y., Yanga, J. J., Yangazov, Y. M., Yousef, O., Yousef, G., Yunus, A. A., Yusuf, A. S., Zeiton, A. Z., Zentuti, H. Z., Zepharine, H., Zerihun, A. B., Zhou, S., Zidan, A., Zié, S. Z., Zinyemba, C. Z., Zo, A., Zomahoun, L., Zoobei, N. Z., Zoumenou, E., and Zubia, N. Z.

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2021
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20. Prognostic gene expression signature for high-grade serous ovarian cancer

Author

Bowtell, D., Chenevix-Trench, G., Green, A., Webb, P., DeFazio, A., Gertig, D., Traficante, N., Fereday, S., Moore, S., Hung, J., Harrap, K., Sadkowsky, T., Pandeya, N., Malt, M., Mellon, A., Robertson, R., Vanden Bergh, T., Jones, M., Mackenzie, P., Maidens, J., Nattress, K., Chiew, Y.E., Stenlake, A., Sullivan, H., Alexander, B., Ashover, P., Brown, S., Corrish, T., Green, L., Jackman, L., Ferguson, K., Martin, K., Martyn, A., Ranieri, B., White, J., Jayde, V., Mamers, P., Bowes, L., Galletta, L., Giles, D., Hendley, J., Alsop, K., Schmidt, T., Shirley, H., Ball, C., Young, C., Viduka, S., Tran, Hoa, Bilic, Sanela, Glavinas, Lydia, Brooks, Julia, Stuart-Harris, R., Kirsten, F., Rutovitz, J., Clingan, P., Glasgow, A., Proietto, A., Braye, S., Otton, G., Shannon, J., Bonaventura, T., Stewart, J., Begbie, S., Friedlander, M., Bell, D., Baron-Hay, S., Ferrier,a, A., Gard, G., Nevell, D., Pavlakis, N., Valmadre, S., Young, B., Camaris, C., Crouch, R., Edwards, L., Hacker, N., Marsden, D., Robertson, G., Beale, P., Beith, J., Carter, J., Dalrymple, C., Houghton, R., Russell, P., Links, M., Grygiel, J., Hill, J., Brand, A., Byth, K., Jaworski, R., Harnett, P., Sharma, R., Wain, G., Ward, B., Papadimos, D., Crandon, A., Cummings, M., Horwood, K., Obermair, A., Perrin, L., Wyld, D., Nicklin, J., Davy, M., Oehler, M.K., Hall, C., Dodd, T., Healy, T., Pittman, K., Henderson, D., Miller, J., Pierdes, J., Blomfield, P., Challis, D., McIntosh, R., Parker, A., Brown, B., Rome, R., Allen, D., Grant, P., Hyde, S., Laurie, R., Robbie, M., Healy, D., Jobling, T., Manolitsas, T., McNealage, J., Rogers, P., Susil, B., Sumithran, E., Simpson, I., Phillips, K., Rischin, D., Fox, S., Johnson, D., Lade, S., Loughrey, M., O’Callaghan, N., Murray, W., Waring, P., Billson, V., Pyman, J., Neesham, D., Quinn, M., Underhill, C., Bell, R., Ng, L.F., Blum, R., Ganju, V., Hammond, I., Leung, Y., McCartney, A., Buck, M., Haviv, I., Purdie, D., Whiteman, D., Zeps, N., Millstein, J., Budden, T., Goode, E.L., Anglesio, M.S., Talhouk, A., Intermaggio, M.P., Leong, H.S., Chen, S., Elatre, W., Gilks, B., Nazeran, T., Volchek, M., Bentley, R.C., Wang, C., Chiu, D.S., Kommoss, S., Leung, S.C.Y., Senz, J., Lum, A., Chow, V., Sudderuddin, H., Mackenzie, R., George, J., Steed, H., Koziak, J.M., Köbel, M., McNeish, I.A., Goranova, T., Ennis, D., Macintyre, G., Silva De Silva, D., Ramón y Cajal, T., García-Donas, J., Hernando Polo, S., Rodriguez, G.C., Cushing-Haugen, K.L., Harris, H.R., Greene, C.S., Zelaya, R.A., Behrens, S., Fortner, R.T., Sinn, P., Herpel, E., Lester, J., Lubiński, J., Oszurek, O., Tołoczko, A., Cybulski, C., Menkiszak, J., Pearce, C.L., Pike, M.C., Tseng, C., Alsop, J., Rhenius, V., Song, H., Jimenez-Linan, M., Piskorz, A.M., Gentry-Maharaj, A., Karpinskyj, C., Widschwendter, M., Singh, N., Kennedy, C.J., Harnett, P.R., Gao, B., Johnatty, S.E., Sayer, R., Boros, J., Winham, S.J., Keeney, G.L., Kaufmann, S.H., Larson, M.C., Luk, H., Hernandez, B.Y., Thompson, P.J., Wilkens, L.R., Carney, M.E., Trabert, B., Lissowska, J., Brinton, L., Sherman, M.E., Bodelon, C., Hinsley, S., Lewsley, L.A., Glasspool, R., Banerjee, S.N., Stronach, E.A., Haluska, P., Ray-Coquard, I., Mahner, S., Winterhoff, B., Slamon, D., Levine, D.A., Kelemen, L.E., Benitez, J., Chang-Claude, J., Gronwald, J., Wu, A.H., Menon, U., Goodman, M.T., Schildkraut, J.M., Wentzensen, N., Brown, R., Berchuck, A., deFazio, A., Gayther, S.A., García, M.J., Henderson, M.J., Rossing, M.A., Beeghly-Fadiel, A., Fasching, P.A., Orsulic, S., Karlan, B.Y., Konecny, G.E., Huntsman, D.G., Bowtell, D.D., Brenton, J.D., Doherty, J.A., Pharoah, P.D.P., and Ramus, S.J.

Published
2020
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21. Elite athletes' and support staffs' experiences and perceptions of long-haul travel, and the self-management strategies they use.

Author

Rossiter, Antonia, Comyns, Thomas M., Sherwin, Ian, Nevill, Alan M., and Warrington, Giles D.

Subjects
ELITE athletes, TRAVEL hygiene, SLEEP interruptions, FATIGUE (Physiology), CHI-squared test, INTERNATIONAL competition
Abstract

Elite athletes and their support staff are often required to travel for international competitions all over the globe, however little is known about their experiences of long-haul (LH) travel and its perceived effects on performance. The aim of this study was to explore elite athletes' and support staffs' perception of symptoms experienced following LH travel and the self-management strategies they used to mitigate these symptoms. Elite athletes and support staff (n = 88), who had embarked on an LH flight (> 8 hours) in the previous 2 years for training or competition, completed a survey examining their perceptions of LH travel, symptoms experienced following the flight(s) and strategies they implemented to minimise the symptoms. Associations between symptoms experienced and travel strategies used with participant and journey characteristics were examined by Chi-squared tests. LH travel was widely perceived by participants to be disruptive to physical (86.4%) and mental performance (72.7%) and to increase the risk of illness and injury (86.4%). The most common symptoms experienced were related to fatigue and disruption to sleep. All participants implemented strategies to help mitigate the negative consequences of LH travel. Moving and stretching regularly in-flight and simple strategies for aligning the body clock to destination time were most prevalent. The study findings will allow the translation of research to better inform future guidelines that address the unique needs and priorities of elite athletes and support staff as they embark on LH travel for training and competition with a view to optimising performance outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Characteristics Of Injury In Rugby Union On Artificial And Natural Playing Surfaces

Author

Kenny, Ian C., primary, Billingham, Tabitha, additional, Dolan, Patrick, additional, Cahalan, Roisin, additional, Warrington, Giles D., additional, Yeomans, Caithriona, additional, Glynn, Liam G., additional, Campbell, Mark J., additional, Lyons, Mark, additional, Harrison, Andrew J., additional, Purtill, Helen, additional, Mulvihill, John J., additional, and Comyns, Thomas M., additional

Published
2023
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32. Risk factors for acute ankle sprains in field-based, team contact sports: a systematic review of prospective etiological studies.

Author

Dolan, Patrick, Kenny, Ian, Glynn, Liam, Campbell, Mark, Warrington, Giles D, Cahalan, Roisin, Harrison, Andrew, Lyons, Mark, and Comyns, Thomas

Abstract

The aim of this systematic review was to identify prospectively measured ankle sprain risk factors in field-based team contact sports. Eight databases including SPORTDiscus, CINAHL Complete, MEDLINE (EBSCO), Education Source, Web of Science, Scopus, Embase, and Pubmed were searched using specific Boolean terms. A modified-CASP diagnostic test assessed the quality of the included studies. Extensive data extraction included but was not limited to injury definition, protocols for injury diagnosis and recording, and outcomes associated with ankle sprain. 4012 records were returned from the online search and 17 studies met the inclusion criteria for this review. Twelve different risk factors including anatomic alignment of the foot and ankle, joint laxity, height, mass, BMI (body mass index), age, ankle strength, hip strength, single leg landing performance (ground reaction force, pelvic internal rotation, and knee varus), and single leg reach were all found to be associated with ankle sprain incidence. Injury definitions and methods of diagnosis and recording varied across the 17 studies. This review updates the literature on prospective risk factors for ankle sprain in a specific population rather than heterogeneous cohorts previously studied. From more than 20 categories of risk factors investigated for ankle sprain association across 17 studies in field-based team contact sports, 12 variables were found to be associated with increased incidence of ankle sprain. In order to reduce the risk of ankle sprain, BMI, ankle plantar and dorsiflexion strength, hip strength, and single leg landing performance should be factored in to athlete assessment and subsequent program design. More studies utilizing standardized definitions and methods of recording and reporting are needed. Future prospective etiological studies will allow strength and conditioning coaches, physiotherapists, and physicians to apply specific training principles to reduce the risk and occurrence of ankle sprain injuries. [ABSTRACT FROM AUTHOR]

Published
2023
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33. Utilising geochemical data for the identification and characterisation of mineral exploration sample media within cover sequence materials.

Author

Tiddy, C. J., Hill, S. M., Giles, D., van der Hoek, B. G., Normington, V. J., Anand, R. R., Baudet, E., Custance, K., Hill, R., Johnson, A., McLennan, S., Mitchell, C., Zivak, D., Salama, W., Stoate, K., and Wolff, K.

Subjects
PROSPECTING, SAND, WATERSHEDS, GEOCHEMISTRY, WEATHERING
Abstract

A first pass workflow for placing cover sequence materials into four broad lithological groups using A-CNK-FM (Al2O3-CaOþNa2OþK2O-Fe2O3þMgO) and A-CN-K (Al2O3-CaOþNa2O-K2O) ternary diagrams in conjunction with the SiO2 vs Al2O3, Fe2O3 and CaO plus the Ca versus Sr XY diagrams has been derived from lithological logging and laboratory whole-rock geochemistry of 2346 samples. These lithological groups include siliciclastics (quartz sands and clays), weathered material, carbonate lithologies (marine limestone, pedogenic carbonate and compositions intermediate between the two end members) and ferruginous lithologies (including ferricrete and ferruginous sediments). Depositional, weathering and groundwater processes influence sample geochemistry during or after the formation of the material and will influence where the sample will plot on the geochemical diagrams used in this study. Geochemical data for discrete lithologies targeted during sampling (e.g. carbonate lithologies) clusters on diagrams used in the geochemical workflow, whereas data from targeted stratigraphic horizons (e.g. basement-cover interface) are more variable. The ability to characterise rock types that are texturally defined using the geochemical workflow is limited. For instance, the geochemistry of diamictite/conglomerate samples is dependent on the matrix versus clast content and composition as well as the source rock and catchment area. This workflow has the potential to be applied in a mineral exploration environment for rapid interpretation of real-time geochemical (e.g. portable XRF) data to gain an understanding of background geochemistry and geochemical signatures that may be related to underlying mineralisation. [ABSTRACT FROM AUTHOR]

Published
2023
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34. A method to collect representative samples from water-driven percussion drilling techniques: examples from RoXplorer® coiled tubing drill rig.

Author

van der Hoek, B., Blaine, F., Giles, D., Tiddy, C., Mostofi, M., and Soe, S.

Subjects
DRILLING fluids, BORING & drilling (Earth & rocks), DRILLING muds, TUBES, PROSPECTING, OIL well drilling rigs
Abstract

Water-driven percussion drilling techniques, such as that used by the RoXplorerVR coiled tubing drill rig, return a rock sample as cuttings that are carried to the surface by the circulating drilling fluid. This drilling technique does not deliver a core sample. In order for the RoXplorerVR to be effective as a mineral-exploration drill rig, it is critical to develop robust, representative and repeatable sampling techniques for the rock cuttings and to establish with confidence the depth interval from which the sample was derived. The RoXplorerVR produces more than 7 kg/m of cuttings every few minutes (rate of penetration dependent) that are carried to the surface by the drilling fluid with a fluid return rate of 80-150 L/min. The cuttings, which range in size from <10 mm to 5 mm, require extraction from the drilling fluid and preparation prior to analysis. Subsampling of the fluid/cuttings stream can reduce the sample size to allow easier processing. A modified static cone splitter and ancillary flow-control system were designed and tested during field deployment of the RoXplorerVR drill rig in South Australia in February 2017. We drilled a vertical hole with RoXplorerVR starting 10m to the northeast of an existing vertical diamond drill hole with well-characterised, shallow-dipping sedimentary and volcanic units. This allows comparison of drilling performance and sample quality against industry-standard drilling and sampling techniques. The performance of the splitter to take a representative continuous 1/8th subsample of drilling fluid and cuttings by volume was assessed based on its ability to resolve a 1m interval of low-grade Cu mineralisation (0.74-1.03 wt% Cu) at 398m that was detected in the reference diamond drill hole. The coiled tubing samples produced an equivalent and unbiased (chemistry and particle-size distribution) subsample, with sub-metre depth accuracy and comparable signal magnitude of the mineralisation at 398m as detected in the diamond core. [ABSTRACT FROM AUTHOR]

Published
2023
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35. Functional rare and low frequency variants in BLK and BANK1 contribute to human lupus

Author

Simon H. Jiang, Vicki Athanasopoulos, Julia I. Ellyard, Aaron Chuah, Jean Cappello, Amelia Cook, Savit B. Prabhu, Jacob Cardenas, Jinghua Gu, Maurice Stanley, Jonathan A. Roco, Ilenia Papa, Mehmet Yabas, Giles D. Walters, Gaetan Burgio, Kathryn McKeon, James M. Byers, Charlotte Burrin, Anselm Enders, Lisa A. Miosge, Pablo F. Canete, Marija Jelusic, Velibor Tasic, Adrian C. Lungu, Stephen I. Alexander, Arthur R. Kitching, David A. Fulcher, Nan Shen, Todor Arsov, Paul A. Gatenby, Jeff J. Babon, Dominic F. Mallon, Carmen de Lucas Collantes, Eric A. Stone, Philip Wu, Matthew A. Field, Thomas D. Andrews, Eun Cho, Virginia Pascual, Matthew C. Cook, and Carola G. Vinuesa

Subjects
Science
Abstract

Function-altering variants of immune-related genes cause rare autoimmune syndromes, whereas their contribution to common autoimmune diseases remains uncharacterized. Here the authors show that rare variants of lupus-associated genes are present in the majority of lupus patients and healthy controls, but only the variants found in lupus patients alter gene function.

Published
2019
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36. Classical and Quantum Radiation Reaction

Author

Martin, Giles D. R.

Subjects
General Relativity and Quantum Cosmology, Quantum Physics
Abstract

This thesis reports on work undertaken in comparing the effects of the phenomenon of radiation reaction in classical and quantum theories of electrodynamics. Specifically, it is concerned with the prediction of the change in position of a particle due to the inclusion of the self-force in the theory. We calculate this position shift for the classical theory, treating radiation reaction as a perturbation in line with the reduction of order procedure. We calculate the contributions to the position shift in the $\hbar\to 0$ limit of quantum field theory to order $e^2$ in the coupling, the order of the classical self-force. These calculations contain the emission and forward scattering one loop processes of quantum electrodynamics. The quantum calculations are completed for the case of a particle represented by a scalar field wave packet and then for a particle represented by the Dirac spinor field. We additionally give an alternative derivation of the scalar results using the interpretation of radiation reaction via a Green's function decomposition, in order to explain and contrast the results achieved., Comment: PhD Thesis, 239 pages

Published
2008

39. Quantum Radiation Reaction and the Green's Function Decomposition

Author

Higuchi, Atsushi and Martin, Giles D. R.

Subjects
General Relativity and Quantum Cosmology, High Energy Physics - Theory, Quantum Physics
Abstract

We analyze the change in position (the position shift) of the wave packet of a charged scalar particle due to radiation reaction in the $\hbar \to 0$ limit of quantum electrodynamics. In particular, we re-express the formula previously obtained for the position shift in terms of Green's functions for the electromagnetic field, thus clarifying the relation between the quantum and classical derivations of the radiation-reaction force., Comment: 4 pages, Latex (Revtex). 1 Figure

Published
2006
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40. Radiation reaction on charged particles in three-dimensional motion in classical and quantum electrodynamics

Author

Higuchi, Atsushi and Martin, Giles D. R.

Subjects
Quantum Physics, High Energy Physics - Theory
Abstract

We extend our previous work (see arXiv:quant-ph/0501026), which compared the predictions of quantum electrodynamics concerning radiation reaction with those of the Abraham-Lorentz-Dirac theory for a charged particle in linear motion. Specifically, we calculate the predictions for the change in position of a charged scalar particle, moving in three-dimensional space, due to the effect of radiation reaction in the one-photon-emission process in quantum electrodynamics. The scalar particle is assumed to be accelerated for a finite period of time by a three-dimensional electromagnetic potential dependent only on one of the spacetime coordinates. We perform this calculation in the $\hbar\to 0$ limit and show that the change in position agrees with that obtained in classical electrodynamics with the Lorentz-Dirac force treated as a perturbation. We also show for a time-dependent but space-independent electromagnetic potential that the forward-scattering amplitude at order $e^2$ does not contribute to the position change in the $\hbar \to 0$ limit after the mass renormalization is taken into account., Comment: Latex, 20pages

Published
2005
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41. Classical and quantum radiation reaction for linear acceleration

Author

Higuchi, Atsushi and Martin, Giles D. R.

Subjects
Quantum Physics, High Energy Physics - Theory
Abstract

We investigate the effect of radiation reaction on the motion of a wave packet of a charged scalar particle linearly accelerated in quantum electrodynamics. We give the details of the calculations for the case where the particle is accelerated by a static potential that were outlined in Phys.Rev. D 70 (2004) 081701(R) and present similar results in the case of a time-dependent but space-independent potential. In particular, we calculate the expectation value of the position of the charged particle after the acceleration, to first order in the fine structure constant in the $\hbar \to 0$ limit, and find that the change in the expectation value of the position (the position shift) due to radiation reaction agrees exactly with the result obtained using the Lorentz-Dirac force in classical electrodynamics for both potentials. We also point out that the one-loop correction to the potential may contribute to the position change in this limit., Comment: 14 pages, 4 figures, REVTeX. Details and extension of calculations outlined in Phys.Rev. D70 (2004) 081701(R), quant-ph/0407162

Published
2005
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43. The Lorentz-Dirac force from QED for linear acceleration

Author

Higuchi, Atsushi and Martin, Giles D. R.

Subjects
Quantum Physics, High Energy Physics - Theory
Abstract

We investigate the motion of a wave packet of a charged scalar particle linearly accelerated by a static potential in quantum electrodynamics. We calculate the expectation value of the position of the charged particle after the acceleration to first order in the fine structure constant in the hbar -> 0 limit. We find that the change in the expectation value of the position (the position shift) due to radiation reaction agrees exactly with the result obtained using the Lorentz-Dirac force in classical electrodynamics. We also point out that the one-loop correction to the potential may contribute to the position change in this limit., Comment: 4 pages, no figures, REVTeX

Published
2004
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44. The Multiple Faces of Valosin-Containing Protein-Associated Diseases: Inclusion Body Myopathy with Paget’s Disease of Bone, Frontotemporal Dementia, and Amyotrophic Lateral Sclerosis

Author

Nalbandian, Angèle, Donkervoort, Sandra, Dec, Eric, Badadani, Mallikarjun, Katheria, Veeral, Rana, Prachi, Nguyen, Christopher, Mukherjee, Jogeshwar, Caiozzo, Vincent, Martin, Barbara, Watts, Giles D, Vesa, Jouni, Smith, Charles, and Kimonis, Virginia E

Subjects
Neurosciences, Dementia, Brain Disorders, Genetics, Rare Diseases, Neurodegenerative, Aging, Acquired Cognitive Impairment, 2.1 Biological and endogenous factors, Aetiology, Musculoskeletal, Neurological, Adenosine Triphosphatases, Amyotrophic Lateral Sclerosis, Animals, Autophagy, Cell Cycle Proteins, DNA-Binding Proteins, Disease Models, Animal, Frontotemporal Dementia, Genetic Association Studies, Humans, Mutation, Myositis, Inclusion Body, Osteitis Deformans, Valosin Containing Protein, Valosin containing protein, Amyotrophic lateral sclerosis, Inclusion body myopathy, Paget's disease of bone, Frontotemporal dementia, NFKB, Ubiquitin, TAR DNA Binding Protein-43, Endoplasmic reticulum associated degradation, Cognitive Sciences, Neurology & Neurosurgery
Abstract

Inclusion body myopathy associated with Paget's disease of bone and frontotemporal dementia (IBMPFD) is a progressive, fatal genetic disorder with variable penetrance, predominantly affecting three main tissue types: muscle (IBM), bone (PDB), and brain (FTD). IBMPFD is caused by mutations in the ubiquitously expressed valosin-containing protein (VCP) gene, a member of the AAA-ATPase superfamily. The majority of individuals who develop IBM have progressive proximal muscle weakness. Muscle biopsies reveal rimmed vacuoles and inclusions that are ubiquitin- and TAR DNA binding protein-43 (TDP-43)-positive using immunohistochemistry. PDB, seen in half the individuals, is caused by overactive osteoclasts and is associated clinically with pain, elevated serum alkaline phosphatase, and X-ray findings of coarse trabeculation and sclerotic lesions. FTD diagnosed at a mean age of 55 years in a third of individuals is characterized clinically by comprehension deficits, dysnomia, dyscalculia, and social unawareness. Ubiquitin- and TDP-43-positive neuronal inclusions are also found in the brain. Genotype-phenotype correlations are difficult with marked intra-familial and inter-familial variations being seen. Varied phenotypes within families include frontotemporal dementia, amyotrophic lateral sclerosis, Parkinsonism, myotonia, cataracts, and anal incompetence, among others. Cellular and animal models indicate pathogenetic disturbances in IBMPFD tissues including altered protein degradation, autophagy pathway alterations, apoptosis, and mitochondrial dysfunction. Currently, mouse and drosophila models carrying VCP mutations provide insights into the human IBMPFD pathology and are useful as tools for preclinical studies and testing of therapeutic strategies. In this review, we will explore the pathogenesis and clinical phenotype of IBMPFD caused by VCP mutations.

Published
2011

45. Classical and quantum radiation reaction

Author

Martin, Giles D. R.

Subjects
510
Abstract

This thesis reports on work undertaken in comparing the effects of the phenomenon of radiation reaction in classical and quantum theories of electrodynamics. Specifically, it is concerned with the prediction of the change in position of a particle due to the inclusion of the self-force in the theory. We calculate this position shift for the classical theory, treating radiation reaction as a perturbation in line with the reduction of order procedure. We calculate the contributions to the position shift in the Ii -t 0 limit of quantum field theory to order e2 in the coupling, the order of the classical self-force. Thes~ calculations contain the emission and forward scattering one loop processes of quantum electrodynamics. The quantum calculations are completed for the case of a particle represented by a scalar field wave packet and then for a particle represented by the Dirac spinor field. We additionally give an alternative derivation of the scalar results using the interpretation of radiation reaction via a Green's function decomposition, in order to explain and contrast the results achieved.

Published
2007

46. VCP Associated Inclusion Body Myopathy and Paget Disease of Bone Knock-In Mouse Model Exhibits Tissue Pathology Typical of Human Disease

Author

Badadani, Mallikarjun, Nalbandian, Angele, Watts, Giles D., Vesa, Jouni, Kitazawa, Masashi, Su, Hailing, Tanaja, Jasmin, Dec, Eric, Wallace, Douglas C., Mukherjee, Jogeshwar, Caiozzo, Vincent, Warman, Matthew, and Kimonis, Virginia E.

Subjects
valosin-containing protein, frontotemporal dementia, aaa-atpase, endoplasmic-reticulum, cell-death, autophagic vacuoles, gene-expression, mice, ubiquitin, p97
Abstract

Dominant mutations in the valosin containing protein (VCP) gene cause inclusion body myopathy associated with Paget's disease of bone and frontotemporal dementia (IBMPFD). We have generated a knock-in mouse model with the common R155H mutation. Mice demonstrate progressive muscle weakness starting approximately at the age of 6 months. Histology of mutant muscle showed progressive vacuolization of myofibrils and centrally located nuclei, and immunostaining shows progressive cytoplasmic accumulation of TDP-43 and ubiquitin-positive inclusion bodies in quadriceps myofibrils and brain. Increased LC3-II staining of muscle sections representing increased number of autophagosomes suggested impaired autophagy. Increased apoptosis was demonstrated by elevated caspase-3 activity and increased TUNEL-positive nuclei. X-ray microtomography (uCT) images show radiolucency of distal femurs and proximal tibiae in knock-in mice and uCT morphometrics shows decreased trabecular pattern and increased cortical wall thickness. Bone histology and bone marrow derived macrophage cultures in these mice revealed increased osteoclastogenesis observed by TRAP staining suggestive of Paget bone disease. The VCPR155H/+ knock-in mice replicate the muscle, bone and brain pathology of inclusion body myopathy, thus representing a useful model for preclinical studies.

Published
2010

47. Valosin containing protein associated inclusion body myopathy: abnormal vacuolization, autophagy and cell fusion in myoblasts

Author

Vesa, Jouni, Su, Hailing, Watts, Giles D, Krause, Sabine, Walter, Maggie C, Martin, Barbara, Smith, Charles, Wallace, Douglas C, and Kimonis, Virginia E

Subjects
Biomedical and Clinical Sciences, Biological Psychology, Clinical Sciences, Neurosciences, Psychology, Rare Diseases, Aging, 2.1 Biological and endogenous factors, Aetiology, Musculoskeletal, Neurological, Adenosine Triphosphatases, Adult, Apoptosis, Autophagy, Caspase 3, Cell Cycle Proteins, Cell Fusion, Cells, Cultured, Down-Regulation, Female, Frontotemporal Dementia, Humans, In Situ Nick-End Labeling, Lysosomal-Associated Membrane Protein 2, Lysosome-Associated Membrane Glycoproteins, Male, Microscopy, Electron, Transmission, Middle Aged, Muscle Fibers, Skeletal, Mutation, Myoblasts, Myositis, Inclusion Body, Osteitis Deformans, Valosin Containing Protein, IBMPFD, Inclusion body myopathy, Paget's disease of the bone, Frontotemporal dementia, VCP, Vacuoles, Medical Physiology, Neurology & Neurosurgery, Clinical sciences, Biological psychology
Abstract

Inclusion body myopathy associated with Paget's disease and frontotemporal dementia (IBMPFD) is caused by mutations in the valosin containing protein (VCP) gene. The disease is associated with progressive proximal muscle weakness, inclusions and vacuoles in muscle fibers, malfunction in the bone remodeling process resulting in Paget's disease, and premature frontotemporal dementia. VCP is involved in several cellular processes related to the endoplasmic reticulum associated degradation of proteins. To understand the pathological mechanisms underlying the myopathy in IBMPFD, we have studied the cellular consequences of VCP mutations in human primary myoblasts. Our results revealed that patients' myoblasts accumulate large vacuoles. Lysosomal membrane proteins Lamp1 and Lamp2 show increased molecular weights in patients' myoblasts due to differential N-glycosylation. Additionally, mutant myoblasts show increased autophagy when cultured in the absence of nutrients, as well as defective cell fusion and increased apoptosis. Our results elucidate that VCP mutations result in disturbances in several cellular processes, which will help us in the understanding of the pathological mechanisms resulting in muscle weakness and other features of VCP associated disease.

Published
2009

48. Rare SH2B3 coding variants identified in lupus patients impair B cell tolerance and predispose to autoimmunity

Author

Zhang, Yaoyuan, primary, Morris, Rhiannon, additional, Lorenzo, Ayla May D, additional, Meng, Xiangpeng, additional, Kershaw, Nadia J, additional, Kiridena, Pamudika, additional, Brown, Grant J, additional, Burgio, Gaetan, additional, Cappello, Jean Y, additional, Shen, Qian, additional, Wang, Hao, additional, Turnbull, Cynthia M, additional, Lea-Henry, Tom, additional, Stanley, Maurice, additional, Yu, Zhijia, additional, Ballard, Fiona, additional, Chuah, Aaron, additional, Lee, James C, additional, Hatch, Ann-Maree, additional, Headley, Alexander P, additional, Trnka, Peter, additional, Mallon, Dominic, additional, Fletcher, Jeffery T, additional, Walters, Giles D, additional, Sestan, Mario, additional, Jelusic, Marija, additional, Cook, Matthew C, additional, Athanasopoulos, Vicki, additional, Fulcher, David A, additional, Babon, Jeffrey J, additional, Vinuesa, Carola G, additional, and Ellyard, Julia I, additional

Published
2023
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