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3. Neutrophil–Lymphocyte Ratio and Absolute Lymphocyte Count as Prognostic Markers in Patients Treated with Curative-intent Radiotherapy for Non-small Cell Lung Cancer

Author

Punjabi, A., Barrett, E., Cheng, A., Mulla, A., Walls, G., Johnston, D., McAleese, J., Moore, K., Hicks, J., Blyth, K., Denholm, M., Magee, L., Gilligan, D., Silverman, S., Qureshi, M., Clinch, H., Hatton, M., Philipps, L., Brown, S., O'Brien, M., McDonald, F., Faivre-Finn, C., Hiley, C., and Evison, M.

Published
2021
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4. Predicting the Risk of Disease Recurrence and Death Following Curative-intent Radiotherapy for Non-small Cell Lung Cancer: The Development and Validation of Two Scoring Systems From a Large Multicentre UK Cohort

Author

Evison, M., Barrett, E., Cheng, A., Mulla, A., Walls, G., Johnston, D., McAleese, J., Moore, K., Hicks, J., Blyth, K., Denholm, M., Magee, L., Gilligan, D., Silverman, S., Hiley, C., Qureshi, M., Clinch, H., Hatton, M., Philipps, L., Brown, S., O'Brien, M., McDonald, F., and Faivre-Finn, C.

Published
2021
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5. Pegargiminase Plus First-Line Chemotherapy in Patients With Nonepithelioid Pleural Mesothelioma

Author

Szlosarek, P, Creelan, B, Sarkodie, T, Nolan, L, Taylor, P, Olevsky, O, Grosso, F, Cortinovis, D, Chitnis, M, Roy, A, Gilligan, D, Kindler, H, Papadatos-Pastos, D, Ceresoli, G, Mansfield, A, Tsao, A, O’Byrne, K, Nowak, A, Steele, J, Sheaff, M, Shiu, C, Kuo, C, Johnston, A, Bomalaski, J, Zauderer, M, Fennell, D, Rybkin, I, Rolfo, C, Mackean, M, Steele, N, Franks, K, Shaw, P, Lind, M, Upadhyay, S, John, T, Karapetis, C, Srivastav, R, Mencoboni, M, Chella, A, Zilembo, N, de Marinis, F, Stella, M, Chong, I, Wang, C, Null, N, Szlosarek, Peter W., Creelan, Benjamin C., Sarkodie, Thomas, Nolan, Luke, Taylor, Paul, Olevsky, Olga, Grosso, Federica, Cortinovis, Diego, Chitnis, Meenali, Roy, Amy, Gilligan, David, Kindler, Hedy, Papadatos-Pastos, Dionysis, Ceresoli, Giovanni L., Mansfield, Aaron S., Tsao, Anne, O’Byrne, Kenneth J., Nowak, Anna K., Steele, Jeremy, Sheaff, Michael, Shiu, Chiung-Fang, Kuo, Chih-Ling, Johnston, Amanda, Bomalaski, John, Zauderer, Marjorie G., Fennell, Dean A., Rybkin, Igor I., Rolfo, Christian D., MacKean, Melanie, Steele, Nicola, Franks, Kevin, Shaw, Paul, Lind, Michael J., Upadhyay, Sunil, John, Thomas, Karapetis, Christos, Srivastav, Ratnesh, Mencoboni, Manlio, Chella, Antonio, Zilembo, Nicoletta, de Marinis, Filippo, Stella, Maria Giulia, Chong, Inn-Wen, Wang, Chin-Chou, null, null, Szlosarek, P, Creelan, B, Sarkodie, T, Nolan, L, Taylor, P, Olevsky, O, Grosso, F, Cortinovis, D, Chitnis, M, Roy, A, Gilligan, D, Kindler, H, Papadatos-Pastos, D, Ceresoli, G, Mansfield, A, Tsao, A, O’Byrne, K, Nowak, A, Steele, J, Sheaff, M, Shiu, C, Kuo, C, Johnston, A, Bomalaski, J, Zauderer, M, Fennell, D, Rybkin, I, Rolfo, C, Mackean, M, Steele, N, Franks, K, Shaw, P, Lind, M, Upadhyay, S, John, T, Karapetis, C, Srivastav, R, Mencoboni, M, Chella, A, Zilembo, N, de Marinis, F, Stella, M, Chong, I, Wang, C, Null, N, Szlosarek, Peter W., Creelan, Benjamin C., Sarkodie, Thomas, Nolan, Luke, Taylor, Paul, Olevsky, Olga, Grosso, Federica, Cortinovis, Diego, Chitnis, Meenali, Roy, Amy, Gilligan, David, Kindler, Hedy, Papadatos-Pastos, Dionysis, Ceresoli, Giovanni L., Mansfield, Aaron S., Tsao, Anne, O’Byrne, Kenneth J., Nowak, Anna K., Steele, Jeremy, Sheaff, Michael, Shiu, Chiung-Fang, Kuo, Chih-Ling, Johnston, Amanda, Bomalaski, John, Zauderer, Marjorie G., Fennell, Dean A., Rybkin, Igor I., Rolfo, Christian D., MacKean, Melanie, Steele, Nicola, Franks, Kevin, Shaw, Paul, Lind, Michael J., Upadhyay, Sunil, John, Thomas, Karapetis, Christos, Srivastav, Ratnesh, Mencoboni, Manlio, Chella, Antonio, Zilembo, Nicoletta, de Marinis, Filippo, Stella, Maria Giulia, Chong, Inn-Wen, Wang, Chin-Chou, and null, null

Abstract

IMPORTANCE Arginine deprivation using ADI-PEG20 (pegargiminase) combined with chemotherapy is untested in a randomized study among patients with cancer. ATOMIC-Meso (ADI-PEG20 Targeting of Malignancies Induces Cytotoxicity-Mesothelioma) is a pivotal trial comparing standard first-line chemotherapy plus pegargiminase or placebo in patients with nonepithelioid pleural mesothelioma. OBJECTIVE To determine the effect of pegargiminase-based chemotherapy on survival in nonepithelioid pleural mesothelioma, an arginine-auxotrophic tumor. DESIGN, SETTING, AND PARTICIPANTS Thiswas a phase 2-3, double-blind randomized clinical trial conducted at 43 centers in 5 countries that included patients with chemotherapy-naive nonepithelioid pleural mesothelioma from August 1, 2017, to August 15, 2021, with at least 12 months' follow-up. Final follow-up was on August 15, 2022. Data analysis was performed from March 2018 to June 2023. INTERVENTION Patients were randomly assigned (1:1) to receive weekly intramuscular pegargiminase (36.8mg/m2) or placebo. All patients received intravenous pemetrexed (500mg/m2) and platinum (75-mg/m2 cisplatin or carboplatin area under the curve 5) chemotherapy every 3 weeks up to 6 cycles. Pegargiminase or placebo was continued until progression, toxicity, or 24 months. MAIN OUTCOMES AND MEASURES The primary end pointwas overall survival, and secondary end points were progression-free survival and safety. Response rate by blinded independent central review was assessed in the phase 2 portion only. RESULTS Among 249 randomized patients (mean [SD] age, 69.5 [7.9] years; 43 female individuals [17.3%] and 206 male individuals [82.7%]), all were included in the analysis. The median overall survival was 9.3 months (95%CI, 7.9-11.8 months) with pegargiminase-chemotherapy as compared with 7.7 months (95%CI, 6.1-9.5 months) with placebo-chemotherapy (hazard ratio [HR] for death, 0.71; 95%CI, 0.55-0.93; P = .02). The median progression-free survival was 6.2 months (

Published
2024

6. A multicentre randomised phase III trial comparing pembrolizumab versus single-agent chemotherapy for advanced pre-treated malignant pleural mesothelioma: the European Thoracic Oncology Platform (ETOP 9-15) PROMISE-meso trial

Author

Popat, S., Curioni-Fontecedro, A., Dafni, U., Shah, R., O'Brien, M., Pope, A., Fisher, P., Spicer, J., Roy, A., Gilligan, D., Gautschi, O., Nadal, E., Janthur, W.D., López Castro, R., García Campelo, R., Rusakiewicz, S., Letovanec, I., Polydoropoulou, V., Roschitzki-Voser, H., Ruepp, B., Gasca-Ruchti, A., Peters, S., and Stahel, R.A.

Published
2020
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7. MA06.06 A Phase II Trial of Ceralasertib and Durvalumab in Advanced Non-Small Cell Lung Cancer (NSCLC) with and without RAS Mutations: Results of NLMT Arm J

Author

Middleton, G., primary, Fletcher, P., additional, Savage, J., additional, Mehmi, M., additional, Greystoke, A., additional, Dangoor, A., additional, Cave, J., additional, Escriu, C., additional, Shaw, P., additional, Steele, N., additional, Jain, P., additional, Popat, S., additional, Forster, M., additional, Spicer, J., additional, Coupe, N., additional, Danson, S., additional, Gilligan, D., additional, Muthukumar, D., additional, Price, G., additional, Summers, Y., additional, Toy, E., additional, and Billingham, L., additional

Published
2023
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8. Multi-decadal trends in large-bodied fish populations in the New South Wales Murray–Darling Basin, Australia

Author

Crook, D. A., primary, Schilling, H. T., additional, Gilligan, D. M., additional, Asmus, M., additional, Boys, C. A., additional, Butler, G. L., additional, Cameron, L. M., additional, Hohnberg, D., additional, Michie, L. E., additional, Miles, N. G., additional, Rayner, T. S., additional, Robinson, W. A., additional, Rourke, M. L., additional, Stocks, J. R., additional, Thiem, J. D., additional, Townsend, A., additional, van der Meulen, D. E., additional, Wooden, I., additional, and Cheshire, K. J. M., additional

Published
2023
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13. Multicentre cohort study to define and validate pathological assessment of response to neoadjuvant therapy in oesophagogastric adenocarcinoma

Author

Noble, F., Lloyd, M. A., Turkington, R., Griffiths, E., OʼDonovan, M., OʼNeill, J. R., Mercer, S., Parsons, S. L., Fitzgerald, R. C., Underwood, T. J., Noorani, A., Fels Elliott, R., Abdullahi, Z., de la Rue, R., Bornschein, J., MacRae, S., Nutzinger, B., Grehan, N., Contino, G., Crawte, J., Edwards, P. A. W., Miremadi, A., Malhotra, S., Hayden, A., Walker, R., Peters, C., Hannah, G., Hardwick, R., Davies, J., Ford, H., Gilligan, D., Safranek, P., Hindmarsh, A., Sujendran, V., Carroll, N., McManus, D., Hayes, S. J., Ang, Y., Preston, S. R., Oakes, S., Bagwan, I., Skipworth, R. J. E., Save, V., Hupp, T. R., Puig, S., Bedford, M., Taniere, P., Whiting, J., Byrne, J., Kelly, J., Owsley, J., Crichton, C., Barr, H., Shepherd, N., Old, O., Lagergren, J., Gossage, J., Davies, A., Chang, F., Zylstra, J., Sanders, G., Berrisford, R., Harden, C., Bunting, D., Lewis, M., Cheong, E., Kumar, B., Saunders, J. H., Soomro, I. N., Vohra, R., Duffy, J., Kaye, P., Grabowska, A., Lovat, L., Haidry, R., Eneh, V., Igali, L., Welch, I., Scott, M., Sothi, S., Suortamo, S., Lishman, S., Beardsmore, D., Sutaria, R., Secrier, M., Eldridge, M.D., Bower, L., Lynch, A. G., and Tavaré, S.

Published
2017
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16. Residual ctDNA after treatment predicts early relapse in patients with early-stage non-small cell lung cancer

Author

Gale, D., primary, Heider, K., additional, Ruiz-Valdepenas, A., additional, Hackinger, S., additional, Perry, M., additional, Marsico, G., additional, Rundell, V., additional, Wulff, J., additional, Sharma, G., additional, Knock, H., additional, Castedo, J., additional, Cooper, W., additional, Zhao, H., additional, Smith, C.G., additional, Garg, S., additional, Anand, S., additional, Howarth, K., additional, Gilligan, D., additional, Harden, S.V., additional, Rassl, D.M., additional, Rintoul, R.C., additional, and Rosenfeld, N., additional

Published
2022
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17. A prognostic score for patients with malignant pleural mesothelioma (MPM) receiving second-line immunotherapy or chemotherapy in the ETOP 9–15 PROMISE-meso phase III trial

Author

Luigi Banna, G. Addeo, A. Zygoura, P. Tsourti, Z. Popat, S. Curioni-Fontecedro, A. Nadal, E. Shah, R. Pope, A. Fisher, P. Spicer, J. Roy, A. Gilligan, D. Gautschi, O. Janthur, W.-D. López-Castro, R. Roschitzki-Voser, H. Dafni, U. Peters, S. Stahel, R.A.

Abstract

Introduction: Clinical and laboratory parameters associated with response for patients with advanced pre-treated malignant pleural mesothelioma (MPM) are lacking. We aimed to identify prognostic and predictive markers among patients with relapsed MPM who were randomised into the ETOP 9–15 PROMISE-meso phase III trial, evaluating pembrolizumab and chemotherapy. Methods: Baseline clinical and laboratory parameters were investigated for prognostic or predictive value on progression-free survival (PFS) and overall survival (OS) in a retrospective analysis, based on the full cohort of 144 MPM patients. These consisted of immune-inflammatory indexes (neutrophil–lymphocyte ratio [NLR], systemic immune-inflammatory index [SII], lactate dehydrogenase [LDH]) along with other already known prognostic baseline characteristics and laboratory values. Cut-offs were chosen independently of outcome. Based on Cox multivariable analysis for PFS in the whole cohort, a risk factor model was built to illustrate the prognostic stratification of patients by the combination of the derived independent prognostic factors, taking into account the EORTC score, a validated prognostic score in MPM. All models were stratified by histology and adjusted by treatment. Results: In the stratified multivariable analysis in the whole cohort, high SII (hazard ratio (HR) 2.06; 95%CI 1.39–3.05) and low haemoglobin (HR 1.62; 95%CI 1.06–2.50) were associated with worse PFS. Based on these two prognostic factors, a mesothelioma risk score (MRS) was constructed with three PFS risk prognosis categories: favourable, intermediate and poor with 0, 1 and 2 risk factors, respectively (corresponding percent of cohort: 24%, 34% and 42% and median PFS: 5.8, 4.2 and 2.1 months). The derived MRS stratified the prognosis for PFS and OS, overall and within each of the EORTC groups. No significant predictors of treatment benefit were identified. Conclusions: The proposed MRS is prognostic of patient outcome and it fine-tunes the prognosis of patients with pre-treated MPM alone or when used with the already established EORTC score. © 2022

Published
2022

21. PH-0274 NLR & ALC as prognostic markers in patients treated with curative intent radiotherapy for NSCLC

Author

Hiley, C., primary, Punjabi, A., additional, Barrett, E., additional, Cheng, A., additional, Mulla, A., additional, Walls, G., additional, Johnston, D., additional, McAleese, J., additional, Moore, K., additional, Hicks, J., additional, Blyth, K., additional, Denholm, M., additional, Magee, L., additional, Gilligan, D., additional, Silverman, S., additional, Qureshi, M., additional, Clinch, H., additional, Hatton, M., additional, Philips, L., additional, Brown, S., additional, O’Brien, M., additional, Macdonald, F., additional, Faivre-Finn, C., additional, and Evison, M., additional

Published
2021
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22. Irish cardiac society: Proceedings of annual general meeting held 1st November, 1997

Author

Seifer, C., McNeill, B., O’Donnell, M., Daly, K., Kellett, J., McGee, H. M., Montogomery, A. J., O’Callaghan, D., Horgan, J. H., Mahon, N. G., Codd, M., Brennan, J., Egan, B., McCann, H. A., Sugrue, D. D., Menown, I. B. A., Patterson, R. S. H. W., McMechan, S. R., Hameed, S., Adgey, A. A. J., Baird, S. H., McBride, S. J., Trouton, T. G., Wilson, C., McRedmond, J. P., Fitzgerald, D. J., Crowley, J. J., Tanguay, J-F., Santos, R. M., Stack, R. S., Mahon, N. G., Keelan, P., McCann, H. A., Sugrue, D. D., McKenna, C. J., AuBuchon, R., Camrud, A. R., Holmes, D. R., Schwartz, R. S., McKenna, C. J., Camrud, A. R., Wolff, R., Edwards, W. D., Holmes, D. R., Schwartz, R. S., Hanratty, C., McAuley, D., Young, I., Murtagh, G., O’Keeffe, B., Richardson, G., Scott, M., Chew, E. W., Bailie, N. A., Graham, A. M. J., O’Kane, H., McKenna, C. J., Kwon, H. M., Ellis, L., Holmes, D. R., Virmani, R., Schwartz, R. S., Noelke, L., Wood, A. E., Javadpour, H., Veerasingham, D., Wood, A. E., O’Kane, D., Allen, J. D., Adgey, A. A. J., Hennessy, T., Johnson, P., Hildick-Smith, D., Winter, E., Shapiro, L., McKenna, C. J., Edwards, W. D., Lerman, A., Holmes, D. R., Schwartz, R. S., McGrath, L. T., Passmore, P., Silke, B., McAuley, D., Nugent, A. G., McGurk, C., Hanratty, C., Maguire, S., Johnston, G. D., McAuley, D., Nugent, A. G., McGurk, C., Hanratty, C., Maguire, S., Johnston, G. D., Lovell, S. L., McDowell, G., McEneany, D., Riley, M. S., Nicholls, D. P., Gilligan, D., Sargent, D., Dan, D., Gilligan, D., Elam, G., Rhee, B., Keane, D., Zhou, L., McGovern, B., Garan, H., Ruskin, J., O’Shea, J. C., Tan, H-C., Zidar, J. P., Stack, R. S., Crowley, J. J., O’Keeffe, D. B., Graffin, S., Fitzsimmons, D., Brown, S., Duff, D., Denham, B., Woods, F., Neligan, M., Oslizlok, P., Connolly, C. K., Danton, M. H. D., O’Kane, H., Danton, M., Gladstone, D. J., Craig, B., Mulholland, H. C., Casey, F., Chaudhuri, S., Hinchion, J., Wood, A. E., Hinchion, J., Wood, A. E., Menown, I. B. A., Patterson, R. H. S. W., MacKenzie, G., Adgey, A. A. J., Harbinson, M. T., Burgess, L. M., Moohan, V., McEneaney, D. J., Adgey, A. A. J., Menown, I. B. A., MacKenzie, G., Patterson, R. S. H. W., Adgey, A. A. J., Finnegan, O. C., Doherty, L., Silke, B., Riddell, J. G., Meleady, R., Daly, L., Graham, I., Quinn, M., Foley, B., Lee, J., Mulvihill, N., Crean, P., Walsh, M., O’Morain, C., Quinn, M., Crean, P., Foley, B., Walsh, M., Hynes, C., King, S. M., David, S., Newton, H., Maguire, M., Rafferty, F., Horgan, J. H., Sullivan, P. A., Murphy, D., Gallagher, S., Menown, I. B. A., Allen, J., Anderson, J. McC, Adgey, A. A. J., Dan, D., Hoag, J., Eckberg, D., Gilligan, D., Galvin, J., Garan, H., McGovern, B., Ruskin, J., Mahon, N. G., Diamond, P., Neilan, T., Keelan, E., H. A., McCarthy, C., Sugrue, D. D., Harbinson, M. T., Moohan, V. P., McEneaney, D. J., Burgess, L. M., Anderson, J. McC, Ayers, G. M., Adgey, A. A. J., Roberts, M., Burgess, L., Anderson, C., Wilson, C., Khan, M., Clements, I. P., Miller, W. L., Seifer, C., O’Donnell, M., McNeill, B., Daly, K., Turtle, F., McDowell, G., Long, H., McNair, W., Campbell, N. P. S., Mathew, T. P., Turtle, F., Smye, M., Nesbitt, G. S., Young, I. S., Adgey, A. A. J., Meleady, R., Mulcahy, D., Graham, I. M., Moore, D., Menown, I. B. A., McMechan, S. R., MacKenzie, G., Adgey, A. A. J., Diamond, P., Sugrue, D., Codd, M. B., Galvin, J., Zimmerman, P., Winget, J., Capeless, M., Galvin, J., Garan, H., McGovern, B., Ruskin, J., McKelvey, T. A., Danton, M. H. D., Sarsam, M. I. A., McEneaney, D., Roberts, M., Burgess, L., Anderson, C., Wilson, C., and Khan, M.

Published
1998
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23. A multicentre randomised phase III trial comparing pembrolizumab versus single-agent chemotherapy for advanced pre-treated malignant pleural mesothelioma: the European Thoracic Oncology Platform (ETOP 9-15) PROMISE-meso trial

Author

Popat, S. Curioni-Fontecedro, A. Dafni, U. Shah, R. O'Brien, M. Pope, A. Fisher, P. Spicer, J. Roy, A. Gilligan, D. Gautschi, O. Nadal, E. Janthur, W.D. López Castro, R. García Campelo, R. Rusakiewicz, S. Letovanec, I. Polydoropoulou, V. Roschitzki-Voser, H. Ruepp, B. Gasca-Ruchti, A. Peters, S. Stahel, R.A.

Abstract

Background: Malignant pleural mesothelioma (MPM) is an aggressive malignancy characterised by limited treatment options and a poor prognosis. At relapse after platinum-based chemotherapy, single-agent chemotherapy is commonly used and single-arm trials of immune-checkpoint inhibitors have demonstrated encouraging activity. Patients and methods: PROMISE-meso is an open-label 1:1 randomised phase III trial investigating the efficacy of pembrolizumab (200 mg/Q3W) versus institutional choice single-agent chemotherapy (gemcitabine or vinorelbine) in relapsed MPM patients with progression after/on previous platinum-based chemotherapy. Patients were performance status 0–1 and unselected for programmed cell death ligand 1 (PD-L1) status. At progression, patients randomly assigned to receive chemotherapy were allowed to crossover to pembrolizumab. The primary end point was progression-free survival (PFS), assessed by blinded independent central review (BICR). Secondary end points were overall survival (OS), investigator-assessed PFS, objective response rate (ORR), and safety. Efficacy by PD-L1 status was investigated in exploratory analyses. Results: Between September 2017 and August 2018, 144 patients were randomly allocated (pembrolizumab: 73; chemotherapy: 71). At data cut-off [20 February 2019, median follow-up of 11.8 months (interquartile range: 9.9–14.5)], 118 BICR-PFS events were observed. No difference in BICR-PFS was detected [hazard ratio = 1.06, 95% confidence interval (CI): 0.73–1.53; P = 0.76], and median BICR-PFS (95% CI) for pembrolizumab was 2.5 (2.1–4.2), compared with 3.4 (2.2–4.3) months for chemotherapy. A difference in ORR for pembrolizumab was identified (22%, 95% CI: 13% to 33%), over chemotherapy (6%, 95% CI: 2% to 14%; P = 0.004). Forty-five patients (63%) assigned to chemotherapy received pembrolizumab at progression. With follow-up to 21 August 2019 [17.5 months: (14.8–19.7)], no difference in OS was detected between groups (HR = 1.12, 95% CI: 0.74–1.69; P = 0.59), even after adjusting for crossover. Pembrolizumab safety was consistent with previous observations. Exploratory efficacy analyses by PD-L1 status demonstrated no improvements in ORR/PFS/OS. Conclusion: This is the first randomised trial evaluating the efficacy of pembrolizumab in MPM patients progressing after/on previous platinum-based chemotherapy. In biologically unselected patients, although associated with an improved ORR, pembrolizumab improves neither PFS nor OS over single-agent chemotherapy. © 2020 European Society for Medical Oncology

Published
2020

25. Irish society of Gastroenterology: Proceedings of summer meeting, boole auditorium, university college, cork on friday 27th and saturday 28th may, 1988.

Author

Murray, D. P., Foley, R., Whelton, M. J., Moriarty, K. J., Brooks, S., Loft, D., Mpoko, N., Gardner, V., Marsh, M. N., Stevens, Fiona M., Kearns, M., Moran, B., Sutton, G., Taylor, M., Karran, S. J., Courtney, M. G., O’Brien, M., McPartlin, J. M., Gibney, M. J., Scott, J. M., Weir, D. G., Suzuki, Y., Tobin, A., Quinn, D., Whelan, A., O’Morain, A., Waldron, R., O’Riordan, M., Kirwan, W. O., Ryan, T., Lennon, J., Crowe, J., Shinkwin, C., Kirwan, W., Mackle, E. J., Parks, T. G., O’Keefe, L., Lanigan, D., O’Donnell, M., Harte, P., O’Sullivan, G., Foley, D. P., Dunne, P., Dervan, P., Crowe, J. P., O’Callaghan, T., Chua, A., Kennedy, N. P., MacMathuna, P., Keating, J. J., Weir, D. G., Keeling, P. W. N., Leen, E., McKenna, D., Gilligan, D., Ward, R., Casey, E., Tobin, A., Hutchinson, L., Sweeney, E. C., O’Morain, C., Collins, J. S. A., Sloan, J. M., Watt, P. H., Hamilton, P. W., Love, A. H. G., Chua, A., Kennedy, N. P., MacMathuna, P., Keating, J. J., Maxwell, W. J., Brennan, D. P., Huang, J., McDonald, G., Weir, D. G., Keeling, P. W. N., Brennan, D. P., Kennedy, N. P., Keeling, P. W. N., McKenna, D., Ward, R., Gilligan, D., Tobin, A., Sweeney, E. C., O’Morain, C., Ryan, T., Lennon, J., Crowe, J., Diamond, T., Rowlands, B. J., Keating, J., O’Reilly, E., Burke, P., McDonald, G. S. A., Monson, J., Stephens, R., Corrigan, O., Keeling, P. W. N., Carey, P. D., Darzi, A., Monson, J. R. T., O’Morain, C., Tanner, W. A., Keane, F. B. V., Darzi, A., Monson, J. R. T., Carey, P. D., O’Morain, C., Tanner, W. A., Keane, F. B. V., Rogers, E., McAnena, O. J., Given, H. F., Keeling, P., O’Sullivan, G., DeMeester, T., Skinner, David B., Collins, J. K., O’Sullivan, G., O’Donoghue, M., O’Brien, F., O’Donovan, T., Corbett, A., Hahnvaganawong, C., Nolan, S., Collins, J., O’Sullivan, G., Murray, J., Hogan, B., Sullivan, M., Doyle, J. S., Butler, P., Walker, F., Murray, J., Doyle, J. S., O’Dwyer, P. J., Minton, J., Enright, H., Patchett, S., O’Connell, L., O’Donoghue, D. P., Afdhal, N. H., Collins, J. S. A., Cattey, R. P., Hogan, W. J., Helm, J. F., Ash, R., O’Briain, D. S., O’Malley, F., and Courtney, G.

Published
1991
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28. Neutrophil lymphocyte ratio as a prognostic marker in patients treated with curative intent radiotherapy for non-small cell lung cancer

Author

Punjabi, A., primary, Barrett, E., additional, Cheng, A., additional, Mulla, A., additional, Walls, G., additional, Burke, D., additional, Mcaleese, J., additional, Moore, K., additional, Hicks, J., additional, Blyth, K., additional, Denholm, M., additional, Magee, L., additional, Gilligan, D., additional, Silverman, S., additional, Qureshi, M., additional, Hatton, M., additional, Clinch, H., additional, Philips, L., additional, Brown, S., additional, Macdonald, F., additional, Faivre-Finn, C., additional, Hiley, C., additional, and Evison, M., additional

Published
2020
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34. Aligning evidence generation and use across health, development, and environment

Author

Tallis, H., Kreis, K., Olander, L., Ringler, C., Ameyaw, D., Borsuk, M. E., Fletschner, D., Game, E., Gilligan, D. O., Jeuland, M., Kennedy, G., Masuda, Y. J., Mehta, S., Miller, N., Parker, M., Pollino, C., Rajaratnam, J., Wilkie, D., Zhang, W., Ahmed, S., Ajayi, O. C., Alderman, H., Arhonditsis, G., Azevedo, I., Badola, R., Bailis, R., Balvanera, P., Barbour, E., Bardini, M., Barton, D. N., Baumgartner, J., Benton, T. G., Bobrow, E., Bossio, D., Bostrom, A., Braimoh, A., Brondizio, E., Brown, J., Bryant, B. P., Calder, R. S., Chaplin-Kramer, B., Cullen, A., DeMello, N., Dickinson, K. L., Ebi, K. L., Eves, H. E., Fanzo, J., Ferraro, P. J., Fisher, B., Frongillo, E. A., Galford, G., Garrity, D., Gatere, L., Grieshop, A. P., Grigg, N. J., Groves, C., Gugerty, M. K., Hamm, M., Hou, X., Huang, C., Imhoff, M., Jack, D., Jones, A. D., Kelsey, R., Kothari, M., Kumar, R., Lachat, C., Larsen, A., Lawrence, M., DeClerck, F., Levin, P. S., Mabaya, E., Gibson, J. M. D., McDonald, R. I., Mace, G., Maertens, R., Mangale, D. I., Martino, R., Mason, S., Mehta, L., Meinzen-Dick, R., Merz, B., Msangi, S., Murray, G., Murray, K. A., Naude, C. E., Newlands, N. K., Nkonya, E., Peterman, A., Petruney, T., Possingham, H., Puri, J., Remans, R., Remlinger, L., Ricketts, T. H., Reta, B., Robinson, B. E., Roe, D., Rosenthal, J., Shen, G., Tallis, H., Kreis, K., Olander, L., Ringler, C., Ameyaw, D., Borsuk, M. E., Fletschner, D., Game, E., Gilligan, D. O., Jeuland, M., Kennedy, G., Masuda, Y. J., Mehta, S., Miller, N., Parker, M., Pollino, C., Rajaratnam, J., Wilkie, D., Zhang, W., Ahmed, S., Ajayi, O. C., Alderman, H., Arhonditsis, G., Azevedo, I., Badola, R., Bailis, R., Balvanera, P., Barbour, E., Bardini, M., Barton, D. N., Baumgartner, J., Benton, T. G., Bobrow, E., Bossio, D., Bostrom, A., Braimoh, A., Brondizio, E., Brown, J., Bryant, B. P., Calder, R. S., Chaplin-Kramer, B., Cullen, A., DeMello, N., Dickinson, K. L., Ebi, K. L., Eves, H. E., Fanzo, J., Ferraro, P. J., Fisher, B., Frongillo, E. A., Galford, G., Garrity, D., Gatere, L., Grieshop, A. P., Grigg, N. J., Groves, C., Gugerty, M. K., Hamm, M., Hou, X., Huang, C., Imhoff, M., Jack, D., Jones, A. D., Kelsey, R., Kothari, M., Kumar, R., Lachat, C., Larsen, A., Lawrence, M., DeClerck, F., Levin, P. S., Mabaya, E., Gibson, J. M. D., McDonald, R. I., Mace, G., Maertens, R., Mangale, D. I., Martino, R., Mason, S., Mehta, L., Meinzen-Dick, R., Merz, B., Msangi, S., Murray, G., Murray, K. A., Naude, C. E., Newlands, N. K., Nkonya, E., Peterman, A., Petruney, T., Possingham, H., Puri, J., Remans, R., Remlinger, L., Ricketts, T. H., Reta, B., Robinson, B. E., Roe, D., Rosenthal, J., and Shen, G.

Abstract

© 2019 The Authors Although health, development, and environment challenges are interconnected, evidence remains fractured across sectors due to methodological and conceptual differences in research and practice. Aligned methods are needed to support Sustainable Development Goal advances and similar agendas. The Bridge Collaborative, an emergent research-practice collaboration, presents principles and recommendations that help harmonize methods for evidence generation and use. Recommendations were generated in the context of designing and evaluating evidence of impact for interventions related to five global challenges (stabilizing the global climate, making food production sustainable, decreasing air pollution and respiratory disease, improving sanitation and water security, and solving hunger and malnutrition) and serve as a starting point for further iteration and testing in a broader set of contexts and disciplines. We adopted six principles and emphasize three methodological recommendations: (1) creation of compatible results chains, (2) consideration of all relevant types of evidence, and (3) evaluation of strength of evidence using a unified rubric. We provide detailed suggestions for how these recommendations can be applied in practice, streamlining efforts to apply multi-objective approaches and/or synthesize evidence in multidisciplinary or transdisciplinary teams. These recommendations advance the necessary process of reconciling existing evidence standards in health, development, and environment, and initiate a common basis for integrated evidence generation and use in research, practice, and policy design.

Published
2019

35. Coupling environment and physiology to predict effects of climate change on the taxonomic and functional diversity of fish assemblages in the Murray-Darling Basin, Australia

Author

Silva, DDP, de Oliveira, AG, Bailly, D, Cassemiro, FAS, do Couto, EV, Bond, N, Gilligan, D, Rangel, TF, Agostinho, AA, Kennard, MJ, Silva, DDP, de Oliveira, AG, Bailly, D, Cassemiro, FAS, do Couto, EV, Bond, N, Gilligan, D, Rangel, TF, Agostinho, AA, and Kennard, MJ

Abstract

This study uses species distribution modeling and physiological and functional traits to predict the impacts of climate change on native freshwater fish in the Murray-Darling Basin, Australia. We modelled future changes in taxonomic and functional diversity in 2050 and 2080 for two scenarios of carbon emissions, identifying areas of great interest for conservation. Climatic-environmental variables were used to model the range of 23 species of native fish under each scenario. The consensus model, followed by the physiological filter of lethal temperature was retained for interpretation. Our study predicts a severe negative impact of climate change on both taxonomic and functional components of ichthyofauna of the Murray-Darling Basin. There was a predicted marked contraction of species ranges under both scenarios. The predictions showed loss of climatically suitable areas, species and functional characters. There was a decrease in areas with high values of functional richness, dispersion and uniqueness. Some traits are predicted to be extirpated, especially in the most pessimistic scenario. The climatic refuges for fish fauna are predicted to be in the southern portion of the basin, in the upper Murray catchment. Incorporating future predictions about the distribution of ichthyofauna in conservation management planning will enhance resilience to climate change.

Published
2019

40. Understanding recent market trends of the US ESCO industry

Author

Stuart, E, Carvallo, JP, Larsen, PH, Goldman, CA, and Gilligan, D

Abstract

© 2018 Springer Science+Business Media B.V., part of Springer Nature The US energy services company (ESCO) industry is an example of a private-sector business model that delivers energy savings to customers primarily through the use of performance-based contracts. US ESCO projects garner significant incremental annual savings: approximately 1% of total US commercial building consumption in 2014. From 2000 to 2011, the industry experienced year over year growth; however, based on information drawn from interviews with ESCO executives conducted in late 2015, the authors find that from 2012 to 2014, ESCO industry revenues did not increase. While public and institutional market sectors accounted for 85% of industry revenue in 2014, consistent with previous research findings, the share of revenue from performance contracting increased to 74% in 2014, as compared to 69% share reported for 2011 and 2008. The revenue numbers between 2011 and 2014 are not fully comparable, because a few ESCOs that were subsidiaries of larger companies had undergone reorganization and some categories of revenue reported in 2011 were not included for 2014. Other factors that may have contributed to the recent revenue trend include the following: (1) increased competition from companies not historically defined as an ESCO (e.g. mechanical contractors), (2) uncertainty among some potential customers about committing to long-term performance contracts, and (3) reduction of performance contracting’s perceived benefit of hedging energy price increases and variability due to customer expectations of continued low and less volatile energy prices.

Published
2018

41. Paying for Digital Information: Assessing Farmers Willingness to Pay for a Digital Agriculture and Nutrition Service in Ghana

Author

Palloni, G., Aker, J., Gilligan, D., Hidrobo, M., and Ledlie, N.

Subjects
Research and Development/ Tech Change/Emerging Technologies
Abstract

With the widespread growth of mobile phone coverage and adoption over the past decade, there has been considerable enthusiasm over the use the ICTs in agricultural initiatives, primarily to disseminate information to farmers. This paper assesses farmers willingness to pay (WTP) for a newly introduced digital nutrition-sensitive agricultural information service in Ghana, called Vodafone Farmers Club (VFC). Using both an experimental game and administrative data, we find that the share of farmers willing-to-pay for VFC service is high at low prices and then decreases rapidly as the price increases; at 1.0 GHC, 85% would register for the service; at 2.0 GHC 50% would register; and at 3.0 GHC, just 19% would still be willing to participate. We experimentally vary both the framing around the introduction of VFC to emphasize either the platform s nutrition and agriculture information or the agriculture information alone and the gender of the household member invited to play the game and find that women have statistically lower WTP than men, but the framing has no impact on WTP. Acknowledgement : We would like to thank all individuals in Upper West and Central Region who agreed to take part in this research. We are particularly grateful to Lucy Billing for managing the project in Ghana, and to the ISSER team in Ghana, led by Simon Bawakyillenuo and Felix Asante. We would also like to extend our gratitude to Groupe Sp ciale Mobile Association (GSMA), Esoko, Vodafone Ghana, and Global Alliance for Improved Nutrition (GAIN) teams for their cooperation and support. We are also extremely grateful for the ongoing collaborative partnership with The Institute of Development Studies (IDS) and the GAMOS team.

Published
2018
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42. PL02.09 National Lung Matrix Trial (NLMT): First Results from an Umbrella Phase II Trial in Advanced Non-Small Cell Lung Cancer (NSCLC)

Author

Middleton, G., primary, Popat, S., additional, Fletcher, P., additional, Summers, Y., additional, Greystoke, A., additional, Gilligan, D., additional, Cave, J., additional, O'Rourke, N., additional, Brewster, A., additional, Toy, E., additional, Spicer, J., additional, Savage, J., additional, Sharpe, R., additional, Yap, T., additional, Swanton, C., additional, and Billingham, L., additional

Published
2019
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43. A multicentre randomized phase III trial comparing pembrolizumab (P) vs single agent chemotherapy (CT) for advanced pre-treated malignant pleural mesothelioma (MPM): Results from the European Thoracic Oncology Platform (ETOP 9-15) PROMISE-meso trial

Author

Popat, S., primary, Curioni-Fontecedro, A., additional, Polydoropoulou, V., additional, Shah, R., additional, O’Brien, M., additional, Pope, A., additional, Fisher, P., additional, Spicer, J., additional, Roy, A., additional, Gilligan, D., additional, Gautschi, O., additional, Nadal, E., additional, Janthur, W.-D., additional, López Castro, R., additional, García Campelo, R., additional, Roschitzki-Voser, H., additional, Ruepp, B., additional, Rusakiewicz, S., additional, Peters, S., additional, and Stahel, R.A., additional

Published
2019
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44. Real-world outcomes with pembrolizumab in patients with treatment-naive advanced/metastatic NSCLC in the UK: multicentre retrospective observational study

Author

Tokaca, N., primary, Gomes, F., additional, Lau, S., additional, Jackson, A., additional, Gradwell, M., additional, Gyi, M., additional, Reinius, M., additional, Valentine, E., additional, Winn, E., additional, Bhosle, J., additional, O’Brien, M., additional, Yousaf, N., additional, Blackhall, F., additional, Gilligan, D., additional, Treece, S., additional, Yip, K., additional, Geldart, T., additional, Baluch, S., additional, Gulliford, T., additional, Muthuramalingam, S., additional, Dancey, G., additional, Britten, A., additional, Brock, J., additional, Stokoe, J., additional, Jain, P., additional, Franks, K., additional, Toy, E., additional, Newsom-Davis, T., additional, Khan, O., additional, Greystoke, A., additional, Ali, C., additional, Leonard, P., additional, Summers, Y., additional, and Popat, S., additional

Published
2019
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45. Irish cardiac society

Author

Seifer, C., McNeill, B., OʼDonnell, M., Daly, K., Kellett, J., McGee, H. M., Montogomery, A. J., OʼCallaghan, D., Horgan, J. H., Mahon, N. G., Codd, M., Brennan, J., Egan, B., McCann, H. A., Sugrue, D. D., Menown, I. B. A., Patterson, R. S. H. W., McMechan, S. R., Hameed, S., Adgey, A. A. J., Baird, S. H., McBride, S. J., Trouton, T. G., Wilson, C., McRedmond, J. P., Fitzgerald, D. J., Crowley, J. J., Tanguay, J F., Santos, R. M., Stack, R. S., Keelan, P., McKenna, C. J., AuBuchon, R., Camrud, A. R., Holmes, D. R., Schwartz, R. S., Wolff, R., Edwards, W. D., Hanratty, C., McAuley, D., Young, I., Murtagh, G., OʼKeeffe, B., Richardson, G., Scott, M., Chew, E. W., Bailie, N. A., Graham, A. M. J., OʼKane, H., Kwon, H. M., Ellis, L., Virmani, R., Noelke, L., Wood, A. E., Javadpour, H., Veerasingham, D., OʼKane, D., Allen, J. D., Hennessy, T., Johnson, P., Hildick-Smith, D., Winter, E., Shapiro, L., Lerman, A., McGrath, L. T., Passmore, P., Silke, B., Nugent, A. G., McGurk, C., Maguire, S., Johnston, G. D., Lovell, S. L., McDowell, G., McEneany, D., Riley, M. S., Nicholls, D. P., Gilligan, D., Sargent, D., Dan, D., Elam, G., Rhee, B., Keane, D., Zhou, L., McGovern, B., Garan, H., Ruskin, J., OʼShea, J. C., Tan, H C., Zidar, J. P., OʼKeeffe, D. B., Graffin, S., Fitzsimmons, D., Brown, S., Duff, D., Denham, B., Woods, F., Neligan, M., Oslizlok, P., Connolly, C. K., Danton, M. H. D., Danton, M., Gladstone, D. J., Craig, B., Mulholland, H. C., Casey, F., Chaudhuri, S., Hinchion, J., Patterson, R. H. S. W., MacKenzie, G., Harbinson, M. T., Burgess, L. M., Moohan, V., McEneaney, D. J., Finnegan, O. C., Doherty, L., Riddell, J. G., Meleady, R., Daly, L., Graham, I., Quinn, M., Foley, B., Lee, J., Mulvihill, N., Walsh, M., OʼMorain, C., Crean, P., Hynes, C., King, S. M., David, S., Newton, H., Maguire, M., Rafferty, F., Sullivan, P. A., Murphy, D., Gallagher, S., Allen, J., Anderson, McC J., Hoag, J., Eckberg, D., Galvin, J., Diamond, P., Neilan, T., Keelan, E., A., H., McCarthy, C., Moohan, V. P., Ayers, G. M., Roberts, M., Burgess, L., Anderson, C., Khan, M., Clements, I. P., Miller, W. L., Turtle, F., Long, H., McNair, W., Campbell, N. P. S., Mathew, T. P., Smye, M., Nesbitt, G. S., Young, I. S., Mulcahy, D., Graham, I. M., Moore, D., Sugrue, D., Codd, M. B., Zimmerman, P., Winget, J., Capeless, M., McKelvey, T. A., Sarsam, M. I. A., and McEneaney, D.

Published
1998
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46. OC-0537: Prophylactic irradiation of tracts (PIT) in patients with pleural mesothelioma: a phase III trial

Author

Bayman, N., primary, Appel, W., additional, Ashcroft, L., additional, Baldwin, D.R., additional, Bates, A., additional, Chappell, B., additional, Darlison, L., additional, Edwards, J., additional, Ezhil, V., additional, Gilligan, D., additional, Hatton, M., additional, Mansy, T., additional, Peake, M., additional, Pemberton, L., additional, Rintoul, R., additional, Ryder, W., additional, Taylor, P., additional, and Faivre-Finn, C., additional

Published
2018
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47. Prophylactic irradiation of tracts (PIT) in patients with pleural mesothelioma: results of a multicentre phase III trial

Author

Bayman, N., primary, Appel, W., additional, Ashcroft, L., additional, Baldwin, D.R., additional, Bates, A.T., additional, Darlison, L., additional, Edwards, J.G., additional, Ezhil, V., additional, Gilligan, D., additional, Hatton, M., additional, Mansy, T., additional, Peake, M.D., additional, Pemberton, L., additional, Rintoul, R.C., additional, Ryder, W.D.J., additional, Taylor, P., additional, and Faivre-Finn, C., additional

Published
2018
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