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4. Emerging Systemic Treatment Options in Atopic Dermatitis

Author

Andaç Salman and Ana M. Giménez-Arnau

Subjects
Medicine
Abstract

Atopic dermatitis (AD) is a chronic inflammatory condition that significantly affects the quality of life of both patients and their families or caregivers. Recently, treatment for moderate-to-severe AD were limited to conventional immunosuppressive therapies. However, currently, with the approval of biologic treatments and oral small molecules in the past decade, the effective and safe management of patients with AD is possible. Despite these advancements, challenges and unmet needs in clinical practice remain. This includes patients who do not respond well to or cannot tolerate existing treatment options and inadequate therapies that can modify the disease course. This review aimed to provide an overview of the current treatment approach for AD, highlight the current challenges in treatment, and discuss the rationale for novel treatment options and emerging evidence on systemic treatment options for AD.

Published
2024
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5. Efficacy of Co-Crystal of Tramadol-Celecoxib (CTC) in Patients with Acute Moderate-to-Severe Pain: A Pooled Analysis of Data from Two Phase 3 Randomized Clinical Trials

Author

Richard Langford, Eugene R. Viscusi, Adelaida Morte, Jesús Cebrecos, Mariano Sust, José María Giménez-Arnau, and Oscar de Leon-Casasola

Subjects
Therapeutics. Pharmacology, RM1-950
Abstract

Abstract Background and Objectives New acute pain medications are needed that provide effective analgesia while minimizing side effects and opioid exposure. Clinical trials of co-crystal of tramadol-celecoxib (CTC) have demonstrated an improved benefit/risk profile versus tramadol or celecoxib alone. We pooled data from two phase 3 clinical trials to evaluate the efficacy of CTC 200 mg twice daily (BID) in acute moderate-to-severe pain. Methods Efficacy data were pooled from STARDOM1 [acute pain following oral surgery (NCT02982161)] and ESTEVE-SUSA-301 [acute pain following bunionectomy (NCT03108482)]. The primary efficacy outcome was sum of pain intensity difference from 0 to 48 h (SPID0–48). Results A total of 344 patients received CTC 200 mg BID, 342 received tramadol 50 or 100 mg four times a day, 181 received celecoxib 100 mg BID, and 172 received placebo. The least-squares mean difference in SPID0–48 was −21.8 (p = 0.002) for CTC versus tramadol and −72.8 (p < 0.001) for CTC versus placebo. A similar pattern of SPID0–48 was observed with CTC versus comparator whether patients had moderate or severe pain at baseline. Reduction in pain intensity was faster and reached mild intensity earlier with CTC versus comparators. Patients were significantly (p ≤ 0.005) less likely to receive rescue medication within 4 or 48 h with CTC compared with tramadol or placebo. Conclusions This pooled analysis reinforces the efficacy profile of CTC versus tramadol and, given that CTC permits lower daily tramadol dosing and thereby reduces unnecessary opioid use, this highlights its improved benefit/risk profile and its potential for the management of moderate-to-severe pain.

Published
2024
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7. [Translated article] Standard and Expanded Series Patch Testing Update by the Spanish Contact Dermatitis and Skin Allergy Research Group (GEIDAC)

Author

Navarro-Triviño, F.J., Borrego, L., Silvestre-Salvador, J.F., Mercader-García, P., Giménez-Arnau, A.M., Ortiz-de Frutos, F.J., Sanz-Sánchez, T., Melé-Ninot, G., Sánchez-Gilo, A., Zaragoza-Ninet, V., Serra-Baldrich, E., Miquel-Miquel, J., Córdoba-Guijarro, S., Rodríguez-Serna, M., Ruíz-González, I., Carrascosa-Carrillo, J.M., Gómez-de la Fuente, E., Pastor-Nieto, M.A., Heras-Mendaza, F., González-Pérez, R., Sánchez-Pedreño Guillén, P., Sánchez-Pérez, J., Gatica-Ortega, M.E., Fernández-Redondo, V., Hervella-Garcés, M., Manrique-Martínez, P., Guimaraens-Juanena, D., García-Gavín, J., Giménez-Arnau, E., Figueras-Nart, I., Curto-Barredo, L., and Armario-Hita, J.C.

Published
2024
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8. Actualización de la batería estándar y batería ampliada de pruebas alérgicas de contacto por el Grupo Español de Investigación en Dermatitis de Contacto y Alergia Cutánea (GEIDAC)

Author

Navarro-Triviño, F.J., Borrego, L., Silvestre-Salvador, J.F., Mercader-García, P., Giménez-Arnau, A.M., Ortiz-de Frutos, F.J., Sanz-Sánchez, T., Melé-Ninot, G., Sánchez-Gilo, A., Zaragoza-Ninet, V., Serra-Baldrich, E., Miquel-Miquel, J., Córdoba-Guijarro, S., Rodríguez-Serna, M., Ruíz-González, I., Carrascosa-Carrillo, J.M., Gómez-de la Fuente, E., Pastor-Nieto, M.A., Heras-Mendaza, F., González-Pérez, R., Sánchez-Pedreño Guillén, P., Sánchez-Pérez, J., Gatica-Ortega, M.E., Fernández-Redondo, V., Hervella-Garcés, M., Manrique-Martínez, P., Guimaraens-Juanena, D., García-Gavín, J., Giménez-Arnau, E., Figueras-Nart, I., Curto-Barredo, L., and Armario-Hita, J.C.

Published
2024
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9. A Patient Charter for Chronic Urticaria

Author

Maurer, Marcus, Albuquerque, Mónica, Boursiquot, Jean-Nicolas, Dery, Elaine, Giménez-Arnau, Ana, Godse, Kiran, Guitiérrez, Guillermo, Kanani, Amin, Lacuesta, Gina, McCarthy, Jessica, Nigen, Simon, and Winders, Tonya

Published
2024
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10. Efficacy and safety of ligelizumab in adults and adolescents with chronic spontaneous urticaria: results of two phase 3 randomised controlled trials

Author

Rosana, Agondi, Ahmed, Al Waily, Fabio, Almerigogna, Miguel Angel Tejedor, Alonso, Alfred, Ammoury, Eng Kim, Anne Goh, Robert, Anolik, Ledit, Ardusso, Petr, Arenberger, Nandini, AS, Mohammad, Asefi, Natalia, Astafieva, Anil, Badhwar, Esther Serra, Baldrich, Christine, Bangert, Annick, Barbaud, Zsuzsanna, Bata-Csorgo, Andrea, Bauer, Frederic, Berard, Beata, Bergler-Czop, Gary D, Berman, Jonathan, Bernstein, Subhash Chandra, Bharija, Ramesh M, Bhat, Isabelle, Boccon-Gibod, Ivan, Botev, Knut, Brockow, Philipp, Buck, Paula, Busse, Regis, Campos, Giorgio Walter, Canonica, Irani, Carla, Julia Maria Del, Carmen, Jaime Del, Carpio, Mamatha, Chadalavada, Yoon-Seok, Chang, Amarjit, Cheema, Yi Hsing, Chen, Yuko, Chinuki, Soyun, Cho, Jeong-Hee, Choi, Chia-Yu, Chu, Ronit, Confino, Jonathan, Corren, Roberta, Criado, Claudia De La, Cruz, David M, Cypcar, Pramila, Daftary, Inna, Danilycheva, Kenneth, Dawes, Michelle Joy, De Vera, James, Deangelo, Stefano, Del Giacco, Diana, Deleanu, John, Delgado, Richard, DeMera, Mohamed, Denguezli, Heinrich, Dickel, Le Huu, Doanh, Sinan, Dogan, Marie Sylvie, Doutre, Anne Sophie, Dupond, Anton, Edin, Kent, EDWARD, Swarna, Ekanayake-Bohling, Daniel, Elbirt, David, Elkayam, Anne, Ellis, Shaunagh, Emanuel, Alexander, Emeliyanov, Burhan, Engin, Luis Felipe, Ensina, Ignacio Antepara, Ercoreca, Safiye, Ergun, Jose Luis Lopez, Estebaranz, Rustem, Fassakhov, Daria, Fomina, Linda, Ford, Mariangela, Francomano, Todd, Funkhouser, Remi, Gagnon, Ricardo, Galimberti, Cesar Alberto, Galvan Calle, Clovis, Galvao, Gabriel, Gattolin, Pierre-Dominique, Ghislain, Ana Maria, Gimenez Arnau, Elliot, Ginchansky, Francoise, Giordano-Labadie, Stanislav, Givirovsky, Kiran, Godse, Shaila, Gogate, Alan, Goldsobel, Francisca, Gomez, Rene Maximiliano, Gomez, Erika, Gonzalez, Paula Ribo, Gonzalez, Dimitar, Gospodinov, Clive, Grattan, Martine, Grosber, Gary, Gross, Francisco Jose Gomez, Guimera Martin-Neda, Rolland, Gyulai, Svetlana, Hadvabova, Suzana Ljubojevic, Hadzavdic, Hadi, Hamam, Daniela, Hasicova, Koremasa, Hayama, Pravin, Hissaria, Anna, Hjerppe, Ivan, Hlinka, Moises Labrador, Horrillo, Connie, Hsu, Yu-Huei, Huang, Iftikhar, Hussain, Atsuyuki, Igarashi, Beata, IMKO-WALCZUK, Huseyin Serhat, Inaloz, Rossella, Intravaia, Neal, Jain, Sanjeev, Jain, Thilo, Jakob, Ruth Cerino, Javier, Antonio, João, Luiza Marek, Jozefowicz, Chang-Gyu, Jung, Martin, Kaatz, Nida, Kacar, Henry, Kanarek, Iva, Karlova, Alexander, Kastanayan, Jana, Kazandjieva, Johannes, Kern, Aharon, Kessel, Neena, Khanna, HeeJoo, Kim, Nancy, Kim, Sang-Ha, Kim, Tae-bum, Kim, Kulli, Kingo, Andreas, Kleinheinz, Janka, Komova, Evangelia, Kompoti, Tomas, Kopal, Peter, Kozub, Dorota, Krasowska, Beata, Krecisz, Burkhard, Kreft, Satsuki, Kubota, Hitoshi, Kudo, Teja, Kulkarni, Kanokvalai, Kulthanan, Akihiro, Kume, Maciej, Kupczyk, Edward, Lain, Bobby, Lanier, Hilde, Lapeere, Griselle Ortiz, Lasanta, Svetlana, Lazareva, Laura, Lazzeri, Dennis, Ledford, Donghun, Lee, Haur Yueh, Lee, Jeffrey, Leflein, Nicolas, Leitz, Nancy, Levin, Hermenio, Lima, Undine, Lippert, Brian, Lipson, Paula, Luna, Gabriel, Magarinos, Satyaprakash, Mahajan, Michail, Makris, Alejandro, Malbran, Ahmed Manjra, Manjra, Michael, Manning, Maria, Manrique, Adriana, Marcipar, Mariano, Marini, Veronique Del, Marmol, Jorge, Maspero, Tomoko, Matsuda, Jonathan, Matz, Marcus, Maurer, Wendy, McFalda, Anne, Mclaughlin, Iris, Medina, Rajesh Dutt, Mehta, Stephan, Meller, Steven, MELTZER, Raisa, Meshkova, Dorin, Mihalache, Francisco Javier, Miquel, Mourad, Mokni, J, Molhoek, Efrain, Montano, Sabine, Mueller, Javier Pedraz, Munoz, Toshikazu, Nagakura, Joanna, Narbutt, Ignasi Figueras, Nart, Ma. Lourdes M, Nebrida-Idea, Trong Hao, Nguyen, Johannes, Niesmann, Violeta Zaragoza, Ninet, Hiromitsu, Noguchi, Yuko Chinuki, Nomura, Roman, Nowicki, Tokuya, Omi, Robert, Onder, Ivan, Orojan, Francisco Javier, Ortiz de Frutos, Kim, Papp, Claudio, Parisi, Chun Wook, Park, Heungwoo, Park, Jungwon, Park, Young Min, Park, Viviana, Parra, Thierry, Passeron, Justine, Pasteur, Shivakumar, Patil, Vergil, Patrascu, Sylvia, Pauser, Anna Wojas, Pelc, Jonathan Grant, Peter, Wolfgang, Pfuetzner, Nicola, Pimpinelli, Andreas, Pinter, Cristian, Pizarro, Karel, Pizinger, Jarmila, Plutinska, Todor, Popov, Veronika, Popova, Marta Ferrer, Puga, Lara Ferrandiz, Pulido, Anca, Purcaru, Ulrike, Raap, Anna, Rajchel, John, Ramey, Ma Deanna Santos, Ramiscal, German Dario, Ramon, Syed, Rehman, Adam, Reich, Norbert, Reider, Krista, Ress, Dimitrios, Rigopoulos, Enrique, Rivas, Heike, Rockmann, Pierre-Paul, Roquet-Gravy, Menachem, Rottem, Vermen Verallo, Rowell, Franziska, Rueff, Juan Alberto Ruano, Ruiz, Juan, Russo, Ronald, Saff, Sarbjit, Saini, Maria, Salazar, Juan Francisco Silvestre, Salvador, Jorge, Sanchez, Florica, Sandru, Mark, Scarupa, Knut, Schaekel, Sibylle, Schliemann, Rik, Schrijvers, Beate, Schwarz, Andreas, Schwinn, Sudhir, Sekhsaria, Nilgun, Senturk, Seong Jun, Seo, Mercedes Rodriguez, Serna, Faradiba, Serpa, Paul A, Shapero, Eriko, Shinkawa, Jan-Christoph, Simon, Rodney, Sinclair, Ralfi, Singer, Dareen D, Siri, Karl, Sitz, Adam, Smialowski, Andrew, Smith, Morten, Soerensen, Wiebke, Sondermann, Haejun, Song, Dmitrii, Sonin, Weily, Soong, Daniel, Soteres, Maria, Staevska-Kotasheva, Petra, Staubach-Renz, Nisha Su Yien, Subash, Gordon, Sussman, Ake Svensson, Svensson, Ekaterini, Syrigou, Andrea, Szegedi, Jacek, Szepietowski, Shunsuke, Takahagi, Yuval, Tal, Neetu, Talreja, Wooi Chiang, Tan, Ricardo, Tan, Jyh Jong, Tang, Tonny, Tanus, Martha, Tarpay, Shang Ian, Tee, Craig, Teller, Florence, Tetart, Aurelie Du, Thanh, Suganthi, Thevarajah, Simon Francis, Thomsen, Carl, Thornblade, Milan, Tjioe, Alberto, Tolcachier, Celeste, Tolentino, Athanasios, Tsianakas, Ilia, Tsingov, Hamida, Turki, Olga, Ukhanova, Jens, Ulrich, Meltem, Uslu, Fernando, Valenzuela, Solange, Valle, Martijn, van Doorn, Jirina, Vankova, Suneel, Vartak, Christine, Vidouria, Sebastian, Volc, Gerald, Volcheck, Nicola, Wagner, Irena, Walecka-Herniczek, Penpun, Wattanakrai, Bettina, Wedi, Steven, Weinstein, Vesarat, Wessagowit, Hugh, Windom, Akiko, Yagami, Aisaku, Yamamoto, Shinichiro, Yasumoto, Young Min, Ye, Jose Cevallos, Yepez, Sang Woong, Youn, Hana, Zelenkova, Oleg, Ziganshin, Matthew, Zook, Maurer, Marcus, Ensina, Luis Felipe, Gimenez-Arnau, Ana Maria, Sussman, Gordon, Hide, Michihiro, Saini, Sarbjit, Grattan, Clive, Fomina, Daria, Rigopoulos, Dimitrios, Berard, Frederic, Canonica, Giorgio Walter, Rockmann, Heike, Szepietowski, Jacek C, Leflein, Jeffrey, Bernstein, Jonathan A, Peter, Jonny G, Kulthanan, Kanokvalai, Godse, Kiran, Ardusso, Ledit, Ukhanova, Olga, Staubach, Petra, Sinclair, Rodney, Gogate, Shaila, Thomsen, Simon Francis, Tanus, Tonny, Ye, Young Min, Burciu, Alis, Barve, Avantika, Modi, Darshna, Scosyrev, Emil, Hua, Eva, Letzelter, Kerstin, Varanasi, Vineeth, Patekar, Manmath, and Severin, Thomas

Published
2024
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11. The DERMACLEAR study: Verification results of a natural language processing system in dermatology

Author

Francisco J. Ortiz de Frutos, Ana M. Giménez‐Arnau, Lluís Puig, Juan F. Silvestre, Esther Serra, Laura Salgado‐Boquete, Vicente García‐Patos, Jose L. L. Estebaranz, Jaime Notario, Ana Martin‐Santiago, Gabriel M. Pontevia, Víctor Martín, Guillermo Guinea, Pau Terradas, and Esteban Daudén

Subjects
deep learning, dermatology, machine learning, natural language processing, OMOP CSM, real world data, Dermatology, RL1-803, Diseases of the genitourinary system. Urology, RC870-923
Abstract

Abstract Background Accurately determining the epidemiology of dermatological diseases such as hidradenitis suppurativa (HS), psoriasis (PsO), chronic urticaria (CU) and/or atopic dermatitis (AD) is challenging due to variations in prevalence and disease severity in the reported literature. Objectives The DERMACLEAR study aims to use natural language processing (NLP) to assess the proportions of patients with HS, PsO, CU and/or AD, and obtain information on patient profiles, patient journeys, and disease and healthcare burden in Spain. Here, the study design and objectives of the DERMACLEAR study are described and the precision of the NLP system used is assessed. Methods This study will retrospectively collect patient information from electronic health records (EHRs) at dermatology departments from seven tertiary hospitals in Spain. The NLP system was developed by IOMED Medical Solutions and was verified internally (IOMED scientific team) and externally (principal investigators of each hospital) to determine its precision in identifying patients with HS, PsO, CU and/or AD. Furthermore, internal verification was performed on other medical variables relevant to the study. Results To date, the DERMACLEAR study has retrospectively collected data from 54,458 patients with HS, PsO, CU and/or AD (HS: 5045; PsO: 32,559; CU: 8397; AD: 12,492). The average precision of the NLP system to identify patients diagnosed with HS, PsO, CU, and/or AD across all hospitals exceeded 95% via external and internal verification. Conclusions Results from the DERMACLEAR study will increase the real‐world evidence of clinical practice, obtaining a large amount of information on patients with the studied diseases. The NLP system used is precise in identifying patients diagnosed with HS, PsO, CU and/or AD, and other medical variables from EHRs, highlighting that it is a valid system to use in the DERMACLEAR study.

Published
2023
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12. Occupational Contact Urticaria Syndrome

Author

Giménez-Arnau, Ana M., Pesqué, David, Maibach, Howard I., Berth-Jones, John, Series Editor, Goh, Chee Leok, Series Editor, Maibach, Howard I., Series Editor, and Giménez-Arnau, Ana M., editor

Published
2023
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15. Non–Skin Related Symptoms Are Common in Chronic Spontaneous Urticaria and Linked to Active and Uncontrolled Disease: Results From the Chronic Urticaria Registry

Author

Pyatilova, Polina, Hackler, Yana, Aulenbacher, Felix, Asero, Riccardo, Bauer, Andrea, Bizjak, Mojca, Day, Cascia, Dissemond, Joachim, Du-Thanh, Aurélie, Fomina, Daria, Giménez-Arnau, Ana M., Grattan, Clive, Gregoriou, Stamatis, Hawro, Tomasz, Kasperska-Zajac, Alicja, Khoshkhui, Maryam, Kocatürk, Emek, Kovalkova, Elena, Kulthanan, Kanokvalai, Kuznetsova, Elizaveta, Makris, Michael, Mukhina, Olga, Pesqué, David, Peter, Jonny, Salameh, Pascale, Siebenhaar, Frank, Sikora, Agnieszka, Staubach, Petra, Tuchinda, Papapit, Zamłyński, Mateusz, Weller, Karsten, Maurer, Marcus, and Kolkhir, Pavel

Published
2024
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16. Dupilumab in patients with chronic spontaneous urticaria (LIBERTY-CSU CUPID): Two randomized, double-blind, placebo-controlled, phase 3 trials

Author

Maurer, Marcus, Casale, Thomas B., Saini, Sarbjit S., Ben-Shoshan, Moshe, Giménez-Arnau, Ana M., Bernstein, Jonathan A., Yagami, Akiko, Stjepanovic, Aleksandra, Radin, Allen, Staudinger, Heribert W., Patel, Naimish, Amin, Nikhil, Akinlade, Bolanle, Fan, Chunpeng, Bauer, Deborah, Yancopoulos, George D., Patel, Kiran, Mannent, Leda P., and Laws, Elizabeth

Published
2024
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17. [Translated article] Epidemiological, Clinical, and Allergic Profile of Psoriatic Patients. Evaluation of the Spanish Registry of Contact Dermatitis and Cutaneous Allergy (REIDAC)

Author

Verdaguer-Faja, J., Borrego, L., Mercader-García, P., González Pérez, R., Córdoba-Guijarro, S., Giménez-Arnau, A.M., Ruiz-González, I., Miquel-Miquel, J., Silvestre, J.F., Ortiz de Frutos, F.J., Tous-Romero, F., Sanz Sánchez, T., Rodríguez-Serna, M., Sánchez-Pérez, J., Serra Baldrich, E., Zaragoza-Ninet, V., Pastor-Nieto, M.A., Gática-Ortega, M.E., Sánchez Gilo, A., Melé-Ninot, G., Sánchez-Pedreño Guillén, P., Munera-Campos, M., Descalzo, M.Á., García-Doval, I., and Carrascosa, J.M.

Published
2024
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18. Patient-Reported Outcome Measures in Atopic Dermatitis and Chronic Urticaria Are Underused in Clinical Practice

Author

Cherrez-Ojeda, Ivan, Bousquet, Jean, Giménez-Arnau, Ana, Godse, Kiran, Krasowska, Dorota, Bartosińska, Joanna, Szczepanik-Kułak, Paulina, Wawrzycki, Bartłomiej, Kolkhir, Pavel, Allenova, Anastasiia, Allenova, Andrey, Tkachenko, Sergey, Teovska Mitrevska, Natasa, Mijakoski, Dragan, Stoleski, Sasho, Kolacinska-Flont, Marta, Kuprys-Lipinska, Izabela, Molinska, Joanna, Kasperska-Zając, Alicja, Zajac, Magdalena, Zamlynski, Mateusz, Mihaltan, Florin, Ulmeanu, Ruxandra, Zalewska-Janowska, Anna, Tomaszewska, Katarzyna, Al-Ahmad, Mona, Al-Nesf, Maryam Ali, Ibrahim, Tayseer, Aqel, Sami, Pesqué, David, Rodríguez-González, Mónica, Wakida-Kuzunoki, Guillermo Hideo, Ramon, German, Ramon, Gonzalo, Neisinger, Sophia, Bonnekoh, Hanna, Rukhadze, Maia, Khoshkhui, Maryam, Fomina, Daria, Larenas-Linnemann, Désirée, Košnik, Mitja, Oztas Kara, Rabia, Caballero López, Chrystopherson Gengyny, Liu, Qiang, Ivancevich, Juan Carlos, Ensina, Luis Felipe, Rosario, Nelson, Kvedariene, Violeta, Ben-Shoshan, Moshe, Criado, Roberta Fachini Jardim, Bauer, Andrea, Cherrez, Annia, Chong-Neto, Herberto, Rojo-Gutierrez, Maria Isabel, Rudenko, Michael, Larco Sousa, José Ignacio, Lesiak, Aleksandra, Matos, Edgar, Muñoz, Nelson, Tinoco, Ivan, Moreno, Jaime, Crespo Shijin, Carolina, Hinostroza Logroño, Romina, Sagñay, Juan, Faytong-Haro, Marco, Robles-Velasco, Karla, Zuberbier, Torsten, and Maurer, Marcus

Published
2024
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19. Perfil epidemiológico, clínico y alérgico en pacientes con psoriasis. Evaluación del Registro Español de Dermatitis de Contacto (REIDAC)

Author

Verdaguer-Faja, J., Borrego, L., Mercader-García, P., González Pérez, R., Córdoba-Guijarro, S., Giménez-Arnau, A.M., Ruiz-González, I., Miquel-Miquel, J., Silvestre, J.F., Ortiz de Frutos, F.J., Tous-Romero, F., Sanz Sánchez, T., Rodríguez-Serna, M., Sánchez-Pérez, J., Serra Baldrich, E., Zaragoza-Ninet, V., Pastor-Nieto, M.A., Gática-Ortega, M.E., Sánchez Gilo, A., Melé-Ninot, G., Sánchez-Pedreño Guillén, P., Munera-Campos, M., Descalzo, M.Á., García-Doval, I., and Carrascosa, J.M.

Published
2024
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20. [Translated article] Drug Survival in Cyclosporine Treatment for Moderate to Severe Atopic Dermatitis: Analysis of the Spanish Atopic Dermatitis Registry (BIOBADATOP)

Author

Couselo-Rodríguez, C., Batalla, A., Carrascosa, J.M., Chicharro, P., González-Quesada, A., de la Cueva, P., Giménez-Arnau, A.M., Gilaberte, Y., Rodríguez-Serna, M., Montero-Vilchez, T., Ruiz-Villaverde, R., Elosua-González, M., Silvestre-Salvador, J.F., Munera-Campos, M., Sánchez-Pérez, J., Carretero, G., Mauleón-Fernández, C., Curto-Barredo, L., Ballano-Ruiz, A., Botella-Estrada, R., Arias-Santiago, S., Navarro-Triviño, F.J., Roustan-Gullón, G., Betlloch, I., del Alcázar, E., Abalde-Pintos, M.T., Suárez-Perez, J., García-Doval, I., Descalzo, M.Á., and Flórez, Á.

Published
2024
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21. [Translated article] Four-year Epidemiological Surveillance of the Spanish Registry of Research in Contact Dermatitis and Cutaneous Allergy: Current Situation and Trends

Author

Tous-Romero, F., Borrego-Hernando, L., García-Doval, I., Mercader-García, P., Silvester-Salvador, J.F., Sánchez-Gilo, A., Sanz-Sánchez, T., Giménez-Arnau, A.M., Zaragoza-Ninet, V., Miquel-Miquel, J., González Pérez, R., Córdoba-Guijarro, S., Carrascosa-Carrillo, J.M., Gática-Ortega, M.E., Ruíz-González, I., Serra-Baldrich, E., Pastor-Nieto, A., Rodríguez-Serna, M., Sánchez-Pérez, J., Melé i Ninot, G., Sánchez-Pedreño Guillén, P., and Ortiz-de Frutos, J.

Published
2024
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22. Vigilancia epidemiológica en los últimos 4 años del Registro Español de Investigación en Dermatitis de Contacto y Alergia Cutánea: situación actual y tendencias

Author

Tous-Romero, F., Borrego-Hernando, L., García-Doval, I., Mercader-García, P., Silvester-Salvador, J.F., Sánchez-Gilo, A., Sanz-Sánchez, T., Giménez-Arnau, A.M., Zaragoza-Ninet, V., Miquel-Miquel, J., González Pérez, R., Córdoba-Guijarro, S., Carrascosa-Carrillo, J.M., Gática-Ortega, M.E., Ruíz-González, I., Serra-Baldrich, E., Pastor-Nieto, A., Rodríguez-Serna, M., Sánchez-Pérez, J., Melé i Ninot, G., Sánchez-Pedreño Guillén, P., and Ortiz-de Frutos, J.

Published
2024
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23. Supervivencia de la ciclosporina en el tratamiento de la dermatitis atópica moderada-grave: Registro Español de Dermatitis Atópica (BIOBADATOP)

Author

Couselo-Rodríguez, C., Batalla, A., Carrascosa, J.M., Chicharro, P., González-Quesada, A., de la Cueva, P., Giménez-Arnau, A.M., Gilaberte, Y., Rodríguez-Serna, M., Montero-Vilchez, T., Ruiz-Villaverde, R., Elosua-González, M., Silvestre-Salvador, J.F., Munera-Campos, M., Sánchez-Pérez, J., Carretero, G., Mauleón-Fernández, C., Curto-Barredo, L., Ballano-Ruiz, A., Botella-Estrada, R., Arias-Santiago, S., Navarro-Triviño, F.J., Roustan-Gullón, G., Betlloch, I., del Alcázar, E., Abalde-Pintos, M.T., Suárez-Perez, J., García-Doval, I., Descalzo, M.Á., and Flórez, Á.

Published
2024
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24. Contact Urticaria Syndrome: a Comprehensive Review

Author

Giménez-Arnau, Ana M, Pesqué, David, and Maibach, Howard I

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Rare Diseases, Contact urticarial, Immediate, Protein contact dermatitis, Occupational, Dermatitis, Angioedema, Inducible urticarial
Abstract

Purpose of reviewContact urticaria syndrome includes contact urticaria and protein contact dermatitis. Underreport, underdiagnosis, or misdiagnosis of entities within the contact urticaria syndrome is believed to be common, especially in the occupational setting. This review provides a structured overview of the entities comprised in this syndrome as well as the diagnostic work-up and management strategies.Recent findingsContact urticaria syndrome has been increasingly described due to personal protective equipment and hand sanitizers in the context of the COVID-19 pandemic. The use of legal cannabis products has led to a rise in occupational cases of contact urticaria to cannabis. A declining trend in the evolution of contact urticaria has been described for natural rubber latex allergy due to the use of synthetic gloves. Prick test has been proposed as a screening method, particularly if multiple products are to be tested, instead of the classical sequential scheme.SummaryPhysicians should be aware of the growing number of culprit agents leading to contact urticaria syndrome. Clinical presentation may be challenging since it includes immediate urticaria and/or eczema and even more generalized reactions. Diagnosis requires a high degree of suspicion, detailed occupational history, and complementary tests, including skin testing. The best treatment is to avoid contact with the culprit agent and to implement preventive measures.

Published
2022

25. Drug Photosensitivity

Author

Gonçalo, Margarida, Giménez-Arnau, Ana, Katsambas, Andreas D., editor, Lotti, Torello M., editor, Dessinioti, Clio, editor, and D'Erme, Angelo Massimiliano, editor

Published
2023
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27. A global perspective on stepping down chronic spontaneous urticaria treatment: Results of the Urticaria Centers of Reference and Excellence SDown‐CSU study

Author

Murat Türk, Emek Kocatürk, Ragıp Ertaş, Luis Felipe Ensina, Silvia Mariel Ferrucci, Clive Grattan, Christian Vestergaard, Torsten Zuberbier, Marcus Maurer, and Ana Maria Giménez‐Arnau

Subjects
antihistamine, chronic urticaria, cyclosporine, guideline, omalizumab, step down, Immunologic diseases. Allergy, RC581-607
Abstract

Abstract Background Although there have been significant advances in the treatment of chronic spontaneous urticaria (CSU) in recent years, there remains a lack of clear guidance on when and how to step down treatment in responders. This study aims to investigate stepping down approaches of different steps of CSU treatment from a global perspective. Methods “Stepping down chronic spontaneous urticaria treatment” (SDown‐CSU) is an international, multicenter, observational, cross‐sectional, survey‐based study of the Urticaria Centers of Reference and Excellence (UCARE) network. The questionnaire included 48 questions completed by physicians in the UCARE network. Results Surveys completed by 103 physicians from 81 UCAREs and 34 countries were analyzed. Seventy‐eight percent of the participants responded that they had a national urticaria management guideline written by their professional societies and 28% responded that they had to operate under a regulatory guideline proposed by central health funding organizations. Seventy‐two and 58.7% of these national recommendations do not contain any detailed information on when and/or how CSU treatment should be discontinued. There was a lack of detailed information on antihistamines and cyclosporine in particular. A predefined maximum duration was generally not applicable to omalizumab and cyclosporine (81% and 82%, respectively). Nearly all UCAREs step down omalizumab within 6 months from the first controlled status and 42% discontinue cyclosporine after 6 months regardless of the control status. Conclusions The findings from the SDown‐CSU study clearly highlight a global need for guidance on the process of stepping down treatment in CSU. Additionally, the study offers a step‐down algorithm applicable to all stages of CSU treatment.

Published
2024
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28. Solar Urticaria: An Ambispective Study in a Long-term Follow-up Cohort with Emphasis on Therapeutic Predictors and Outcomes

Author

David Pesqué, Andrea Ciudad, Evelyn Andrades, Dulce Soto, Ramon Gimeno, Ramon M. Pujol, and Ana M. Giménez-Arnau

Subjects
Chronic urticaria, Inducible urticaria, omalizumab, predictor, solar urticaria, treatment, Dermatology, RL1-803
Abstract

Solar urticaria is a rare photodermatosis with several unknown pathogenic, clinical and therapeutic aspects. This study analysed the clinical and therapeutic features of a long-term follow-up solar urticaria cohort, with a focus on omalizumab management and outcomes, and characterized omalizumab response with the use of the high-affinity immunoglobulin E (IgE) receptor (FcεRI) and the Urticaria Control Test. An observational, unicentric, ambispective study was conducted from 2007 to 2023. Solar urticaria was diagnosed in 41 patients with a median follow-up of 60 months. Thirteen patients were prescribed omalizumab, with a median treatment time of 48 months. A significant decrease in FcεRI baseline levels and subsequent median increase in Urticaria Control Test was evidenced after omalizumab prescription in all patients. Drug survival at 48 months was at 88.9%. Omalizumab stepping-down protocol led to sustained omalizumab discontinuation in only 1 patient. Median basal Urticaria Control Test was lower (p

Published
2024
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31. Patients With Chronic Spontaneous Urticaria Who Have Wheals, Angioedema, or Both, Differ Demographically, Clinically, and in Response to Treatment—Results From CURE

Author

Buttgereit, Thomas, Vera, Carolina, Aulenbacher, Felix, Church, Martin K., Hawro, Tomasz, Asero, Riccardo, Bauer, Andrea, Bizjak, Mojca, Bouillet, Laurence, Dissemond, Joachim, Fomina, Daria, Giménez-Arnau, Ana M., Grattan, Clive, Gregoriou, Stamatios, Kulthanan, Kanokvalai, Kasperska-Zajac, Alicja, Kocatürk, Emek, Makris, Michael, Kolkhir, Pavel, Weller, Karsten, Magerl, Markus, and Maurer, Marcus

Published
2023
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32. Urticaria exacerbations and adverse reactions in patients with chronic urticaria receiving COVID-19 vaccination: Results of the UCARE COVAC-CU study

Author

Kocatürk, Emek, Salameh, Pascale, Sarac, Esra, Vera Ayala, Carolina E., Thomsen, Simon Francis, Zuberbier, Torsten, Ensina, Luis Felipe, Popov, Todor A., van Doorn, Martijn B.A., Giménez-Arnau, Ana Maria, Asero, Riccardo, Criado, Paulo Ricardo, Aarestrup, Fernando M., AbdulHameed Ansari, Zainab, Al Abri, Salma, Al-Ahmad, Mona, Al Hinai, Bushra, Allenova, Anastasiia, Al-Nesf, Maryam, Altrichter, Sabine, Arnaout, Rand, Bartosińska, Joanna, Bauer, Andrea, Bernstein, Jonathan A., Bizjak, Mojca, Bonnekoh, Hanna, Bouillet, Laurence, Brzoza, Zenon, Calvalcanti Dela Bianca Melo, Ana Caroline, Campinhos, Fernanda L., Carne, Emily, Purayil, Saleema Cherichi, Cherrez-Ojeda, Ivan, Chong-Neto, Herberto Jose, Christoff, George, Conlon, Niall, Jardim Criado, Roberta Fachini, Cvenkel, Klara, Damadoglu, Ebru, Danilycheva, Inna, Day, Cascia, de Montjoye, Laurence, Demir, Semra, Ferucci, Silvia Mariel, Fomina, Daria, Fukunaga, Atsushi, Garcia, Elizabeth, Gelincik, Asli, Göbel, Joe Hannah, Godse, Kiran, Gonçalo, Margarida, Gotua, Maia, Grattan, Clive, Gugala, Agata, Guillet, Carole, Kalyoncu, Ali Fuat, Karakaya, Gul, Kasperska-Zając, Alicja, Katelaris, Constance H., Khoshkhui, Maryam, Kleinheinz, Andreas, Kolacinska-Flont, Marta, Kolkhir, Pavel, Košnik, Mitja, Krasowska, Dorota, Kumaran, Muthu Sendhil, Kuprys-Lipinska, Izabela, Kurowski, Marcin, Kuznetsova, Elizaveta V., Larenas-Linnemann, Désirée, Lebedkina, Marina S., Lee, Youngsoo, Makris, Michael, Gómez, René Maximiliano, Nasr, Iman, Neisinger, Sophia, Oda, Yoshiko, Kara, Rabia Öztaş, Palitot, Esther Bastos, Papapostolou, Niki, Salvador Parisi, Claudio Alberto, Pesque, David, Peter, Jonathan, Petkova, Elena, Ridge, Katie, Rudenko, Michael, Rutkowski, Krzysztof, Saini, Sarbjit S., Salman, Andac, Sanchez, Jorge, Şekerel, Bülent, Serdotetskova, Sofia A., Serpa, Faradiba S., Dikicier, Bahar Sevimli, Sidiropoulos, Nikitas, Sikora, Agnieszka, Sørensen, Jennifer Astrup, Soria, Angele, Kucuk, Ozlem Su, Thalappil, Sherin Rahim, Tomaszewska, Katarzyna, Tuncay, Gulseren, Unal, Derya, Valle, Solange, van Lindonk, Esmee, Vestergaard, Christian, Meshkova, Raisa Y., Vitchuk, Aleksandr, Xepapadaki, Paraskevi, Ye, Young-Min, Zalewska-Janowska, Anna, Zamlynski, Mateusz, and Maurer, Marcus

Published
2023
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33. Urticarial Vasculitis Differs From Chronic Spontaneous Urticaria in Time to Diagnosis, Clinical Presentation, and Need for Anti-Inflammatory Treatment: An International Prospective UCARE Study

Author

Bonnekoh, Hanna, Jelden-Thurm, Jannis, Allenova, Anastasiia, Chen, Yudi, Cherrez-Ojeda, Ivan, Danilycheva, Inna, Dorofeeva, Irina, Jardim Criado, Roberta Fachini, Criado, Paulo Ricardo, Gelincik Akkor, Asli, Hawro, Tomasz, Kocatürk, Emek, Khoshkhui, Maryam, Metz, Martin, Nasr, Iman, Steć, Michał, Zhao, Zuotao, Aulenbacher, Felix, Salameh, Pascale, Altrichter, Sabine, Gonçalo, Margarida, Gimenez-Arnau, Ana, Maurer, Marcus, Krause, Karoline, and Kolkhir, Pavel

Published
2023
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34. A concept for integrated care pathways for atopic dermatitis—A GA2LEN ADCARE initiative

Author

Torsten Zuberbier, Amir Abdul Latiff, Xenofon Aggelidis, Matthias Augustin, Radu‐Gheorghe Balan, Christine Bangert, Lisa Beck, Thomas Bieber, Jonathan A. Bernstein, Marta Bertolin Colilla, Alejandro Berardi, Anna Bedbrook, Carsten Bindslev‐Jensen, Jean Bousquet, Marjolein deBruin‐Weller, Dayanne Bruscky, Betul Buyuktiryaki, Giorgio Walter Canonica, Carla Castro, Natia Chanturidze, Herberto Jose Chong‐Neto, Chia‐Yu Chu, Leena Chularojanamontri, Michael Cork, Roberta F. J. Criado, Laia Curto Barredo, Adnan Custovic, Ulf Darsow, Arben Emurlai, Ana dePablo, Stefano DelGiacco, Giampiero Girolomoni, Tanja Deleva Jovanova, Mette Deleuran, Nikolaos Douladiris, Bruno Duarte, Ruta Dubakiene, Esben Eller, Batya Engel‐Yeger, Luis Felipe Ensina, Nelson Rosario Filho, Carsten Flohr, Daria Fomina, Wojciech Francuzik, Maria Laura Galimberti, Ana M. Giménez‐Arnau, Kiran Godse, Charlotte Gotthard Mortz, Maia Gotua, Michihiro Hide, Wolfram Hoetzenecker, Nicolas Hunzelmann, Alan Irvine, Carolyn Jack, Ioanna Kanavarou, Norito Katoh, Tamar Kinaciyan, Emek Kocatürk, Kanokvalai Kulthanan, Hilde Lapeere, Susanne Lau, Mariana Machado Forti Nastri, Michael Makris, Eli Mansour, Alexander Marsland, Mara Morelo Rocha Felix, Ana Paula Moschione Castro, Eustachio Nettis, J. F. Nicolas, Audrey Nosbaum, Mikaela Odemyr, Niki Papapostolou, Claudio A. S. Parisi, Sushil Paudel, Jonny Peter, Prakash Pokharel, Luis Puig, Tamara Quint, German Dario Ramon, Frederico Regateiro, Giampaolo Ricci, Cristine Rosario, Cansin Sackesen, Peter Schmid‐Grendelmeier, Esther Serra‐Baldrich, Kristina Siemens, Cathrine Smith, Petra Staubach, Katarina Stevanovic, Özlem Su‐Kücük, Gordon Sussman, Simona Tavecchio, Natasa Teovska Mitrevska, Diamant Thaci, Elias Toubi, Claudia Traidl‐Hoffmann, Regina Treudler, Zahava Vadasz, Ingrid vanHofman, Maria Teresa Ventura, Zhao Wang, Thomas Werfel, Andreas Wollenberg, Ariana Yang, Yik Weng Yew, Zuotao Zhao, Ricardo Zwiener, and Margitta Worm

Subjects
atopic dermatitis, eczema, guidance, ICP, integrated care pathways, multidisciplinary, Immunologic diseases. Allergy, RC581-607
Abstract

Abstract Introduction The integrated care pathways for atopic dermatitis (AD‐ICPs) aim to bridge the gap between existing AD treatment evidence‐based guidelines and expert opinion based on daily practice by offering a structured multidisciplinary plan for patient management of AD. ICPs have the potential to enhance guideline recommendations by combining interventions and aspects from different guidelines, integrating quality assurance, and describing co‐ordination of care. Most importantly, patients can enter the ICPs at any level depending on AD severity, resources available in their country, and economic factors such as differences in insurance reimbursement systems. Methods The GA2LEN ADCARE network and partners as well as all stakeholders, abbreviated as the AD‐ICPs working group, were involved in the discussion and preparation of the AD ICPs during a series of subgroup workshops and meetings in years 2020 and 2021, after which the document was circulated within all GAL2EN ADCARE centres. Results The AD‐ICPs outline the diagnostic procedures, possible co‐morbidities, different available treatment options including differential approaches for the pediatric population, and the role of the pharmacists and other stakeholders, as well as remaining unmet needs in the management of AD. Conclusion The AD‐ICPs provide a multidisciplinary plan for improved diagnosis, treatment, and patient feedback in AD management, as well as addressing critical unmet needs, including improved access to care, training specialists, implementation of educational programs, assessment on the impact of climate change, and fostering a personalised treatment approach. By focusing on these key areas, the initiative aims to pave the way for a brighter future in the management of AD.

Published
2023
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37. Contact Dermatitis: Overcoming Challenges of Specific Patients, Deciphering the Results and Reaching a Correct Diagnosis

Author

Marcelino, João, Giménez-Arnau, Ana M., Barrett, James E., Editor-in-Chief, Flockerzi, Veit, Editorial Board Member, Frohman, Michael A., Editorial Board Member, Geppetti, Pierangelo, Editorial Board Member, Hofmann, Franz B., Editorial Board Member, Kuner, Rohini, Editorial Board Member, Michel, Martin C., Editorial Board Member, Page, Clive P., Editorial Board Member, Wang, KeWei, Editorial Board Member, Rosenthal, Walter, Editorial Board Member, Traidl-Hoffmann, Claudia, editor, Zuberbier, Torsten, editor, and Werfel, Thomas, editor

Published
2022
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38. The Benefit of Complete Response to Treatment in Patients With Chronic Spontaneous Urticaria—CURE Results

Author

Kolkhir, Pavel, Laires, Pedro A., Salameh, Pascale, Asero, Riccardo, Bizjak, Mojca, Košnik, Mitja, Dissemond, Joachim, van Doorn, Martijn, Hawro, Tomasz, Kasperska-Zajac, Alicja, Zajac, Magdalena, Kocatürk, Emek, Peter, Jonny, Parisi, Claudio A.S., Ritchie, Carla A., Kulthanan, Kanokvalai, Tuchinda, Papapit, Fomina, Daria, Kovalkova, Elena, Khoshkhui, Maryam, Kouzegaran, Samaneh, Papapostolou, Niki, Du-Thanh, Aurélie, Kamegashira, Akiko, Meshkova, Raisa, Vitchuk, Alexander, Bauer, Andrea, Grattan, Clive, Staubach, Petra, Bouillet, Laurence, Giménez-Arnau, Ana M., Maurer, Marcus, and Weller, Karsten

Published
2023
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45. Are antihistamines still used during omalizumab treatment for chronic spontaneous urticaria?

Author

Melé-Ninot, Gemma, Serra-Baldrich, Esther, Spertino, Jorge, Guilarte, Mar, Ribó González, Paula, Lleonart-Bellfill, Ramon, Figueras-Nart, Ignasi, Bonfill-Ortí, Montserrat, Depreux, Nathalie, Sala-Cunill, Anna, Bielsa-Marsol, Isabel, Baliu-Piqué, Carola, Sanmartín-Novell, Verònica, Garcia-Navarro, Xavier, Expósito-Serrano, Vicente, Garnica-Velandia, Diana, Diaz-Sarrió, Maria Carmen, Gómez-Armayones, Sara, Gich Saladich, Ignasi, and Giménez-Arnau, Ana

Published
2022
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46. Remibrutinib inhibits hives effector cells stimulated by serum from chronic urticaria patients independently of FcεR1 expression level and omalizumab clinical response

Author

Ramón Gimeno, Clara Ribas‐Llauradó, David Pesque, Evelyn Andrades, Bruno Cenni, Barbara Ambros, Ramon Pujol, and Ana M. Giménez‐Arnau

Subjects
basophils, Bruton's tyrosine kinase, chronic urticaria, IgE, mast cells, omalizumab, Immunologic diseases. Allergy, RC581-607
Abstract

Abstract Background Despite advances in the treatment of chronic urticaria, in a significant percentage of the patients symptoms are not fully controlled with conventional approaches. New strategies under development include blocking intracellular mediators of mast cell and basophil activation. Objective We aim to investigate the effects of the Bruton's tyrosine kinase (BTK) inhibitor remibrutinib on human blood basophils and CD34+‐derived mast cells activation induced by serum obtained from chronic urticaria patients. Methods Twenty‐two patients with chronic spontaneous urticaria (mean age 52 years, 27% women) and 22 patients with chronic inducible urticaria (46 years, 27% women) were included in the study together with a sex‐matched control group. Patients were classified as responders or non‐responders to anti‐IgE therapy on the basis of their clinical data, FcεR1a expression on blood basophils and total IgE levels. Changes on CD63 expression—as an activation marker‐, were used to evaluate in vitro the response of basophils and mast cells to serum exposure and the inhibitory effects of remibrutinib. Results Remibrutinib inhibits degranulation induced by IgE cross‐linking in mast cells and basophils and also the activation triggered by factors present in the sera of spontaneous and inducible chronic urticaria patients. Patient's serum induces a greater degranulation of effector cells than controls. Activation of mast cells and basophils by patient sera and remibrutinib effects were not related to omalizumab responsiveness. Conclusion Remibrutinib inhibits activation of human basophils and mast cells induced in vitro by exposure to the serum of chronic urticaria patients independently of their response to omalizumab.

Published
2023
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47. Recomendaciones del Grupo Español de Investigación en Dermatitis de Contacto y Alergia Cutánea (GEIDAC) de la AEDV en relación con la realización de pruebas epicutáneas durante la pandemia por SARS-CoV-2 (COVID-19)

Author

Armario Hita, José Carlos, Borrego Hernando, Leopoldo, Carrascosa Carrillo, José Manuel, Córdoba Guijarro, Susana, Curto, Laia, Fernández Redondo, Virginia, Figueras Nart, Ignasi, García Gavín, Juan, Elena Gatica Ortega, María, Giménez Arnau, Anna, Giménez Arnau, Elena, Gómez de la Fuente, Enrique, González Pérez, Ricardo, Heras Mendaza, Felipe, Hervella Garcés, Marcos, Manrique Martínez, Pilar, Mercader García, Pedro, Javier Ortiz de Frutos, Francisco, Miquel Miquel, Javier, Antonia Pastor Nieto, María, Rodríguez Serna, Mercedes, Ruíz González, Inmaculada, Sánchez Gilo, Araceli, Sánchez-Pedreño Guillén, Paloma, Sánchez Pérez, Javier, Sanz Sánchez, Tatiana, Serra-Baldrich, Esther, Silvestre Salvador, Juan Francisco, Zaragoza Ninet, Violeta, Carrascosa, J.M., Pastor-Nieto, M.A., Ruiz-González, I., Silvestre, J.F., Borrego, L., Gatica-Ortega, M.E., and Giménez-Arnau, A.M.

Published
2020
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48. Urticaria

Author

Kolkhir, Pavel, Giménez-Arnau, Ana M., Kulthanan, Kanokvalai, Peter, Jonny, Metz, Martin, and Maurer, Marcus

Published
2022
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49. Perfil epidemiológico, clínico, y alérgico en pacientes con dermatitis atópica y dermatitis de las manos. Evaluación del Registro Español de Dermatitis de Contacto (REIDAC)

Author

V. Mora-Fernández, P. Mercader Garcia, L. Borrego Hernando, R. González Pérez, S. Córdoba Guijarro, A. Giménez Arnau, I. Ruiz González, F.J. Miquel Miquel, J.F. Silvestre Salvador, F.J. Ortiz de Frutos, T. Sanz Sanchez, M. Rodríguez Serna, V. Fernández Redondo, J. Sanchez Perez, F. Heras Mendaza, E. Serra Baldrich, V. Zaragoza Ninet, M.A. Pastor Nieto, M. Hervella Garcia, I. Garcia Doval, and J.M. Carrascosa

Subjects
Atopic dermatitis, Hand eczema, Contact dermatitis, Sensitization, Allergy, Eczema, Dermatology, RL1-803, Internal medicine, RC31-1245
Abstract

Resumen: Antecedentes: La dermatitis de las manos (DM) es frecuente en los pacientes con dermatitis atópica (DA). Pocos estudios describen las características de estos pacientes a partir de poblaciones amplias y representativas de ámbitos geográficos y laborales diferentes. Objetivos: Describir el perfil epidemiológico, clínico y alérgico de los pacientes con DM a los que se realizan pruebas epicutáneas, comparando los pacientes con DA con los pacientes sin DA. Métodos. El estudio se ha realizado a partir de los datos del REIDAC, un registro multicéntrico nacional de pacientes a los que se realizan pruebas epicutaneas. Resultados: Se incluyeron 1466 pacientes parcheados por DM desde enero de 2018 hasta junio de 2020. Los pacientes con DA fueron más jóvenes y con una duración de los síntomas mayor. Los antecedentes ocupacionales como desencadenantes se registraron en menor medida que en los pacientes no atópicos (38 vs 53%). La única profesión en la que se encontraron diferencias significativas fue la peluquería. Los alérgenos más detectados fueron el sulfato de níquel, la metilcloroisotiazolinona/metilisotiazolinona, el cloruro de cobalto, el dicromato potásico, mezcla de fragancias I y II, y el formaldehido. Los diagnósticos más frecuentes fueron dermatitis alérgica de contacto (DAC); 24% en atópicos vs 31% en no atópicos (p 0.0224) y el eccema de contacto irritativo; 18% atópicos vs 35% no atópicos (p

Published
2022
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