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1. Coronavirus-19 infection in kidney transplant recipients: A comprehensive review

Author

Gina DeFelice and Adarsh Vijay

Subjects
Diseases of the genitourinary system. Urology, RC870-923
Abstract

The COVID-19 pandemic has disrupted health care across the globe. Since the beginning of the pandemic, there have been substantial changes in the approach toward kidney transplantation and management of the virus in transplant recipients. Chronic immunosuppression and comorbidities in renal transplant recipients place them at risk during the pandemic. Data on the risk factors, presentation, and management of kidney transplant patients have become more robust over time. Relevant data on this topic was procured and synthesized with the aid of a comprehensive Medline search on all published studies that investigated COVID-19 infection in kidney transplant recipients. This comprehensive review summarizes the current literature on the epidemiology, clinical features, complications, graft outcomes, and current management of COVID-19 infection in kidney transplant recipients. We further summarize published literature on immunization in kidney transplant recipients.

Published
2022
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2. Fourth Annual Summer Research Summit on Health Equity Organized by the Center of Excellence in Health Equity, Training and Research, Baylor College of Medicine, Houston, Texas 77030, USA on May 20, 2021

Author

Aanand Naik, Abbhirami Rajagopal, Adam Floyd, Adriana Gil, Aisha Tepede, Aisha Koroma, Aisha Deslandes, Akua Graf, Alejandra Ruiz-Velasco, Alexa Reyna-Carrillo, Alexandra Alvarenga, Alexia Awoseyi, Alexis Hernandez, Alexis Lawrence, Ali Asghar-Ali, Allyssa Abacan, Alyce Adams, Alyna Khan, Alyson McGregor, Alyssa Hansen, Amari Johnson, Andrea Coj, Andrea Vick, Andria Tatem, Anjali Aggarwal, Anjali Deendyal, Ann Blake, Annabella Awazi, Anne VanHorn, Anuj Marathe, Anusha Jayaram, April Adams, Arabella Hall, Ariana Heredia, Ariana Chavarria, Asha Morrow, Ashley Butler, Asia Hodges, Aura Mejia, Avani Patel, Ayleen Hernandez, Benjamin Akande, Blessing Felix-Okoroji, Brisa Garcia, Buckleitner Jenna, Callie Fischer, Camden Hallmark, Cara Coren, Carlos Ramos, Cecilia Gambala, Charleta Guillory, Chelsea Livingston, Chioma Onyejiaka, Chishinga Callender, Christina Aldrich, Christopher Largaespada, Claire Bocchini, Craig Cochran, Danielle Sherman, Danielle Gonzales, David Venzon, David Wittkower, Debbe Thompson, Deborah Thompson, Debra Eseonu, Deepa Dongarwar, Delia Rospigliosi, Denise Smart, Denisse Velazquez, Derek Lockett, Eberechi Nwogu-Onyemkpa, Elizabeth Byrne, Elyse Lopez, Eric Dybbro, Eric Storch, Erica Onwuegbuchu, Erica Valdes, Erin Donovan, Eunique Williams, Evan Keil, Faith Ihekweazu, Felicia Rosiji, Gabriela Espinoza-Candelaria, Gabriella Chmaitelli, Gabriella Tavera, Gail Oneal, Gal Barbut, Gauvain Tonpouwo, George Carrum, Gina DeFelice, Hamisu Salihu, Heather Haq, Helen Heslop, Houston Lester, Ifeoma Ezenwabachili, Ila Gautham, Jacquelin Powell, Jaime Alleyn, Jasmine King, Jaydira Rivero, Jayer Chung, Jayna Dave, Jean Raphael, Jen Bryan, Jendi Haug, Jennifer Bryan, Jenny Blau, Jerry Bellamy, Jessica Medrano, Jessica Ramirez, Jocelyn Greely, Jonnae Atkinson, Jorge Miranda, Jose Dominguez, Jose Roca, Joseph Mills, Joshua Hamer, Joshua Muñiz, Julliet Ogu, Karen Gibbs, Karen Johnson, Karen Riggins, Karla Fredricks, Keila Lopez, Kellie Williams, Keyishi Peters, Kil Hyein, LaQuisa Hill, Lee Weinstein, Lena Shay, Lentz Lefevre, Lindy Ross, Lisa Noll, Lois Akpati, Lorin Crear, Lucy Puryear, Maame Coleman, Madhuri Vasudevan, Malachi Miller, Maria Vigil-Mallette, Maria Jaramillo, Mariam Chacko, Mariana Baroni, Mariana Murillo, Maricarmen Marroquin, Marina Masciale, Marlene McNeese, Martinez Austin, Matthew Koller, Maya Lee, Maziar Nourian, Megan Abadom, Meghna Sebastian, Meheret Adera, Mei-Lei Laracuente, Michelle Lopez, Michelle Wright, Miguel Montero-Baker, Monica Gonzalez, Morrow Adelene, Mosope Adeyeye, Muzaffar Qazilbash, Namrata Walia, Nancy Shenoi, Natalia Rodriguez, Naya Mukdadi, Neeraj Saini, Norma Olvera, Ololade Chris-Rotimi, Paige Hoyer, Parisa Fallah, Peggy Smith, Premal Lulla, Priscilla Ehieze, Priyanka Murali, Rachel Head, Rachel Nwaneri, Rachelle Wanser, Racquel Lyn, Rammurti Kamble, Ramyar Gilani, Raquel Martinez, Rathi Asaithambi, Reginald Hatter, Rhanna Wilson, Ria Brown, Robert Shulman, Robert Mbilinyi, Robert Levine, Roe Avery, Romil Patel, Roslyn Aduhene-Opoku, Ruth Mizu, Saad Usmani, Sadia Usmani, Saeed Ahmed, Samantha Moore, Samer Hadidi, Sana Erabti, Sana Javed, Sana Younus, Sanders Mar’Quenda, Sandy Samaan, Sara Alam, Sara Welty, Sergio Navarro, Shad Deering, Shaine Morris, Shana Alford, Shangir Siddique, Shantyka Walton, Shayan Bhathena, Shelease O’Bryant, Shital Patel, Sindhu Idicula, Sophia Banu, Sophie Albert, Sophie McCullum, Sophie Lin, Star Okolie, Sunita Agarwal, Susan Gillespie, Syed Hussaini, Sylvia Hysong, Tammy Kang, Tara Everett, Taylor Ottesen, Tiana DiMasi, Tien Nguyen, Toi Harris, Tzu-An Chen, Vicki Mercado, Victoria Michael, Victoria Xie, William Simonds, Yesenya Gonzalez, Yicenia Aviles, Ynhi Thomas, and Zachary Pallister

Subjects
Public aspects of medicine, RA1-1270
Abstract

The fourth annual summer research summit organized by the Center of Excellence (COE) in Health Equity, Training and Research, Baylor College of Medicine (BCM) was held on May 20, 2021. The theme of this year’s summit was ‘Strengthening Our Commitment to Racial and Social Justice to Improve Public Health.’ Given the ongoing pandemic, the summit was conducted virtually through digital platforms. This program was intended for both BCM and external audiences interested in advancing health equity, diversity and inclusion in healthcare among healthcare providers and trainees, biomedical scientists, social workers, nurses, individuals involved in talent acquisition and development such as hiring managers (HR professionals), supervisors, college and hospital affiliate leadership and administrators, as well as diversity and inclusion excellence practitioners. We had attendees from all regions of the United States, India, Pakistan and the Demographic Republic of the Congo. The content in this Book of Abstracts encapsulates a summary of the research efforts by the BCM COE scholars (which includes post-baccalaureate students, medical students, clinical fellows and junior faculty from BCM) as well as the external summit participants. The range of topics in this year’s summit was quite diverse encompassing disparities in relation to maternal and child health (MCH), immigrant heath, cancers, vaccination uptakes and COVID-19 infections. Various solutions were ardently presented to address these disparities including community engagement and partnerships, improvement in health literacy and development of novel technologies and therapeutics. With this summit, BCM continues to build on its long history of educational outreach initiatives to promote diversity in medicine by focusing on programs aimed at increasing the number of diverse and highly qualified medical professionals ready to introduce effective and innovative approaches to reduce or eliminate health disparities. These programs will improve information resources, clinical education, curricula, research and cultural competence as they relate to minority health issues and social determinants of health. The summit received very positive response in terms of zealous participation and outstanding evaluations; and overall, it was a great success. Copyright © 2021 Lopez et al. Published by Global Health and Education Projects, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution License CC BY 4.0.

Published
2021

3. Short and Long-Term Outcomes of Kidney Transplant Recipients Diagnosed With COVID-19 Infection: A Single-Center Observational Study

Author

Gina, Defelice, Sixto, Giusti, Hoonbae, Jeon, Mary, Killackey, Anil, Paramesh, and Adarsh, Vijay

Subjects
General Engineering
Abstract

Kidney transplant recipients (KTRs) are at an increased risk of severe disease and death caused by coronavirus disease 2019 (COVID-19) infection. There is a paucity of information on the evolution of graft function among hospitalized KTRs who overcome the infection.The study included adult KTRs at a single transplant institute who were diagnosed with COVID-19 and needed hospitalization between March 15, 2020, and January 15, 2021. We analyzed patient demographics, comorbid risk factors, and inpatient clinical courses for patients who were able to recover from the infection. Kidney function was analyzed pre-infection, during initial hospitalization, and up to 12 months post-infection.We identified 48 KTRs who were diagnosed with COVID-19 infection during the study period. Eighteen KTRs among these needed hospitalization for symptoms of fever and respiratory distress. Four patients died of COVID-19 infection-related complications and were excluded from the study. The 14 remaining patients in the study were predominantly of the Black race (85.7%), with a median time since transplant of four years. Of the patients, 64.3% developed acute kidney injury (AKI), with an average peak serum creatinine (sCr) of 2.6 mg/dl and a glomerular filtration rate (GFR) of 35. The mean sCr and GFR of the group were 2 mg/dl and 44 at baseline (prior to infection). This represented an increase in their sCr and GFR of 34% and 29%, respectively. The median follow-up post-infection was 14.5 months. sCr and GFR were 1.87 mg/dl and 47 at three to six months, and 1.89 mg/dl and 48 at nine to 12 months post-infection. New onset proteinuria was noted in five out of 14 patients (36%), with complete resolution of the same in all at three to six months follow-up. Of patients with AKI, 78% had complete recovery at three to six months follow-up. The mean baseline sCr and GFR of patients who had incomplete recovery was 2.35 and 31.5 with pre-existing proteinuria. Of our entire cohort, there was only one patient who experienced graft loss. This patient had a baseline sCr and GFR of 3.8 mg/dl and 22, existing proteinuria on urinalysis, and a history of biopsy-proven rejection.AKI is common among KTRs who are hospitalized with COVID-19 infection. Most of these recovered, although we noted that patients with baseline lower kidney function and existing proteinuria had a lower recovery rate.

Published
2022
Full Text
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4. Coronavirus-19 infection in kidney transplant recipients: A comprehensive review

Author

Adarsh Vijay and Gina DeFelice

Subjects
Urology
Abstract

The COVID-19 pandemic has disrupted health care across the globe. Since the beginning of the pandemic, there have been substantial changes in the approach toward kidney transplantation and management of the virus in transplant recipients. Chronic immunosuppression and comorbidities in renal transplant recipients place them at risk during the pandemic. Data on the risk factors, presentation, and management of kidney transplant patients have become more robust over time. Relevant data on this topic was procured and synthesized with the aid of a comprehensive Medline search on all published studies that investigated COVID-19 infection in kidney transplant recipients. This comprehensive review summarizes the current literature on the epidemiology, clinical features, complications, graft outcomes, and current management of COVID-19 infection in kidney transplant recipients. We further summarize published literature on immunization in kidney transplant recipients.

Published
2021

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