1. Effect of ethane-1-hydroxy-1,1-diphosphonate and vitamin D on bone mineralization.
- Author
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Baxter LA, Canty DJ, Bednar GJ, Stern L, DeLuca HF, Ginn DL, Flora L, and Hassing GS
- Subjects
- Animals, Calcium metabolism, Chickens, Intestinal Absorption drug effects, Male, Calcification, Physiologic drug effects, Etidronic Acid pharmacology, Vitamin D pharmacology
- Abstract
Administration of large quantities of ethane-1-hydroxy-1,1-diphosphonate to growing chicks resulted in a decrease in percent bone ash and an increase in percent osteoid. The degree of inhibition of bone mineral accumulation was a function of both duration and quantity of ethane-1-hydroxy-1,1-diphosphonic acid administration. The inhibition of bone mineral accumulation could be partially corrected with administration of 1,25-dihydroxyvitamin D3. Administration of high levels of ethane-1-hydroxy-1,1-diphosphonate also resulted in inhibition of intestinal calcium absorption. This could be reversed or prevented by the administration of 1,25-dihydroxyvitamin D3.
- Published
- 1979
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