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9 results on '"Giovagnoli C"'

1. Covariate Adjusted Designs for Combining Efficiency, Ethics and Randomness in Normal Response Trials

Author

Maroussa Zagoraiou, Alessandro Baldi Antognini, A. C. ATKINSON, A. GIOVAGNOLI, C. MAY, B. TORSNEY, A. Baldi Antognini, and M. Zagoraiou

Subjects
Randomization, Computer science, Order (business), Adaptive design, Covariate, Econometrics, Optimal allocation, Randomness
Abstract

This paper deals with the problem of allocating patients to two competing treatments in the presence of covariates in order to achieve a good trade-off between efficiency, ethical concern and randomization. We propose a compound criterion that combines inferential precision and ethical gain by flexible weights depending on the unknown treatment effects. In the absence of treatment-covariate interactions, this criterion leads to a locally optimal allocation which does not depend on the covariates and can be targeted by a suitable implementation of the doubly-adaptive biased coin design aimed at balancing the roles of randomization, ethics and information. Some properties of the suggested procedure are described.

Published
2010

3. CD spectra and redox reactions of superoxide dismutase from Escherichia coli B: evidence for a Mn(III) enzyme.

Author

Keele BB Jr, Giovagnoli C, and Rotilio G

Subjects
Binding Sites, Circular Dichroism, Electron Spin Resonance Spectroscopy, Ferrocyanides, Hydrogen Peroxide, Kinetics, Manganese analysis, Oxidation-Reduction, Protein Binding, Protein Conformation, Spectrophotometry, Ultraviolet, Escherichia coli enzymology, Metalloproteins metabolism, Superoxide Dismutase metabolism
Abstract

Analysis of the metal content, CD and EPR spectra, and reaction with H(2)O(2) and ferrocyanide have been carried out on E. coli superoxide dismutase, which contains manganese as the metal prosthetic group. The results obtained indicate that the metal is present in the enzyme as a high spin Mn(III) complex of highly distorted octahedral symmetry, in the ratio of approximately 1 atom of manganese per enzyme dimer.

Published
1975

4. The effect of azide on the spectral and catalytic properties of ascorbate oxidase.

Author

Mondovi B, Avigliano L, Rotilio G, Finazzi Agro A, Gerosa P, and Giovagnoli C

Subjects
Binding Sites, Copper analysis, Electron Spin Resonance Spectroscopy, Kinetics, Plants enzymology, Protein Binding, Protein Conformation, Species Specificity, Spectrophotometry, Spectrophotometry, Ultraviolet, Ascorbate Oxidase metabolism, Azides pharmacology, Oxidoreductases
Abstract

(1) 45% of the total copper of green zucchini ascorbate oxidase is EPR-detectable. At least two species of copper are present, one with a small A parallel (Type 1) and one with a large A parallel (Type 2). Computer simulated spectra indicated 50% contribution by each type of copper. (2) Azide inhibited ascorbate oxidase activity by an uncompetitive mechanism. EPR and optical spectra performed on titration of ascorbate oxidase with azide indicated the formation of a copper-azide complex. The Type 2 copper appears to be the binding site of azide. The involvement of the EPR non-detectable copper as an anion binding site with high affinity toward azide can not be excluded.

Published
1975
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5. Effect of sulfur bindng on rhodanese fluorescence.

Author

Finazzi Agrò A, Federici G, Giovagnoli C, Cannella C, and Cavallini D

Subjects
Animals, Cattle, Chemical Phenomena, Chemistry, Cyanides, Energy Transfer, Glycerol, Serum Albumin, Bovine, Spectrometry, Fluorescence, Spectrum Analysis, Sulfites, Thiosulfates, Tryptophan, Viscosity, Binding Sites, Sulfur, Sulfurtransferases
Published
1972
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6. Studies of the metal sites of copper proteins. V. A model compound for the copper site of superoxide dismutase.

Author

Morpurgo L, Giovagnoli C, and Rotilio G

Subjects
Animals, Azides, Binding Sites, Cattle, Copper analysis, Cyanates, Cyanides, Electron Spin Resonance Spectroscopy, Formates, Freezing, Hydrogen-Ion Concentration, Oxidation-Reduction, Polyamines, Protein Binding, Protein Conformation, Spectrophotometry, Spectrophotometry, Ultraviolet, Thiomalates, Metalloproteins analysis, Superoxide Dismutase analysis
Published
1973
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7. Studies of the metal sites of copper proteins. Symmetry of copper in bovine superoxide dismutase and its functional significance.

Author

Rotilio G, Morpurgo L, Giovagnoli C, Calabrese L, and Mondovì B

Subjects
Animals, Azides, Binding Sites, Cattle, Chemical Phenomena, Chemistry, Cyanides, Electron Spin Resonance Spectroscopy, Fluorides, Free Radicals, Mathematics, Osmolar Concentration, Oxygen, Spectrophotometry, Copper, Erythrocytes enzymology, Oxidoreductases
Published
1972
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8. Luminescence quenching in azurin.

Author

Finazzi-Agrò A, Giovagnoli C, Avigliano L, Rotilio G, and Mondovì B

Subjects
Apoproteins analysis, Chemical Phenomena, Chemistry, Circular Dichroism, Copper, Electron Spin Resonance Spectroscopy, Ligands, Luminescent Measurements, Mercury, Models, Chemical, Oxidation-Reduction, Protein Binding, Protein Conformation, Pseudomonas fluorescens, Silver, Sodium Chloride, Spectrometry, Fluorescence, Bacterial Proteins, Metalloproteins analysis
Published
1973
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