Search

Depression is a serious condition that is associated with great psychic suffering and major impairments on the patient's general health, quality of life, and social and occupational activities. In some cases, it may lead to suicide. Regardless of the innumerous research works that have already addressed depression in wide and specific facets, there is still a lot to grasp in order to effectively help preventing and treating depression. This work presents data from a randomized clinical trial that sought to evaluate the effectiveness of two brief psychotherapeutic for Depression: Cognitive Behavioral Therapy (CBT) and Supportive-Expressive Dynamic Psychotherapy (SEDP). This was a convenience sample composed of 46 individuals that were evaluated using a structured diagnostic interview and then randomly allocated to the SEDP group. We examined baseline and post-intervention serum levels of the Interleukin-6 (IL-6) and the Tumor Necrosis Factor (TNF-α) in addition to the severity of depressive symptoms according to the Outcome Questionnaire - 45.2 (OQ-45.2) and the Beck Depression Inventory (BDI). Results show that serum IL-6 and TNF-α levels, as well as the scores from the OQ-45.2 and the BDI significantly decreased after 16 sessions of SEDP (p < 0.001), except for the Interpersonal Relationship domain from the OQ-45. Despite the reduction of serum cytokines levels and OQ-45 and BDI scores, they were only significantly correlated regarding the social role domain from the OQ-45. Nonetheless, our data suggests an effective role of brief psychodynamic psychotherapy in the reduction of depressive symptoms and serum inflammatory levels that are associated with depression.

The aim of this study was to evaluate the effect of two brief psychotherapy models for major depressive disorder (MDD). This is a randomized clinical trial with 247 individuals diagnosed with MDD. Supportive-expressive dynamic psychotherapy (SEDP) (18 sessions) and cognitive-behavioral therapy (CBT) (16 sessions) were the two models used in this study. Participants were evaluated at baseline, during treatment, and postintervention (last session). Clinically significant changes were found in both psychotherapy models, and CBT showed higher response rates. Regarding the Beck Depression Inventory-II [F(1,120) = 4.07, p = 0.046] and Outcome Questionnaire 45.2 [F(1.114) = 7.99, p = 0.006], CBT had a better effect than SEDP. Hence, the results obtained have contributed to literature, served to corroborate the importance and effectiveness of psychodynamic psychotherapy, as well as explored the mechanisms of change, remission, and response in the treatment of MDD, which have been ignored to a large extent.

To evaluate the effect of cognitive therapy on biological rhythm and depressive and anxious symptoms in a twelve-month follow-up period. In addition, correlations between the reduction of depression and anxiety symptoms and the regulation of biological rhythm were observed.This was a randomized clinical trial with young adults from 18 to 29 years of age who were diagnosed with depression. Two models of psychotherapy were used: Cognitive Behavioral Therapy (CBT) and Narrative Cognitive Therapy (NCT). Biological rhythm was assessed with the Biological Rhythm Interview of Assessment in Neuropsychiatry (BRIAN). Severity of depressive and anxious symptoms was assessed by the Hamilton Depression Rating Scale (HDRS) and the Hamilton Anxiety Rating Scale (HARS), respectively. The sample included 97 patients who were divided within the protocols of psychotherapy.There was a significant reduction in depressive and anxious symptoms (p0.001) and an increase on regulation of biological rhythm (p0.05) at the twelve-month follow-up. Moreover, we showed a positive correlation between the reduction of depressive symptoms and regulation of biological rhythm (r=0.638; p0.001) and between the reduction of anxious symptoms and regulation of biological rhythm (r=0.438; p0.001).Both models showed that cognitive therapy was effective on the reduction of depressive and anxious symptoms and on the regulation of biological rhythm at a twelve-month follow-up evaluation. This study highlights the association between biological rhythm and symptoms of depression and anxiety.We did not assess genetic, hormonal or neurochemical factors and we did not include patients under pharmaceutical treatment or those with severe symptomatology.

Objectives To verify the prevalence of current posttraumatic stress disorder (PTSD) in young adults, the occurrence of comorbidities and its association with quality of life. Methods This is a cross-sectional population-based study. The targeted population consisted on individuals aged 18 to 24 years old, who lived in the urban area of Pelotas-RS, Brazil. Cluster sampling was applied. PTSD and its comorbidities were assessed using the Mini International Neuropsychiatric Interview (MINI 5.0), whereas quality of life was evaluated with the eight domains of the Medical Outcomes Survey Short-form General Health Survey (SF-36). Results A total of 1,762 young adults were selected. The prevalence of PTSD was 2.1% and current episode of depression was the most prevalent comorbidity (71.9%). The individuals with PTSD had lower scores in all domains of quality of life. Conclusion These findings indicate that PTSD is associated with other psychopathologies, especially depression, and it has a substantial impact over quality of life in a sample of young adults.

Background: Caregiver burden has been associated with caregivers’ mental disorders and need for support and information. However, the lack of quantitative studies and formal interventions aiming to lower burden levels in this population reflect the current negligence regarding this important issue. Aim: To identify burden levels and associated factors in caregivers of young adults with bipolar and unipolar mood disorder. Method: This is a cross-sectional study nested within a population-based cross-sectional study with young adults. Caregiver burden was assessed through the Burden Interview. Information about caregiver mental disorders (Axis I) and alcohol abuse were obtained through the Mini International Neuropsychiatric Interview (MINI) and the Cut-Down, Annoyed, Guilty and Eye-Opener (CAGE) questionnaire, respectively. Results: Caregiver burden was associated to caregiver’s mood and anxiety disorders, suicide risk and being the caregiver of young adults with depression disorder and bipolar disorder. Also, burden was higher among caregivers of bipolar individuals. When excluding the control group from the analysis, only mood and anxiety disorders remained associated to caregiver burden. Conclusions: Caregivers are affected by the young adult’s disorder even before a diagnosis has been given, with serious impairments in their lives. Thus, this is a subject in need of designing relevant strategies aiming to provide them with care.

Submitted by Cristiane Chim (cristiane.chim@ucpel.edu.br) on 2016-09-12T13:01:17Z No. of bitstreams: 3 Giovanna_Del_Grande_da_Silva_Alves.pdf: 1480052 bytes, checksum: d35fd8b618bd782bdff6ef801dfc68ef (MD5) giovanna 2.pdf: 128634 bytes, checksum: e25d780ccb5d47babf4f4c421249646b (MD5) Silva et al 2016 J Psych Research.pdf: 747242 bytes, checksum: 98e17c2c97366c098d5343dd88ec3b32 (MD5) Made available in DSpace on 2016-09-12T13:01:17Z (GMT). No. of bitstreams: 3 Giovanna_Del_Grande_da_Silva_Alves.pdf: 1480052 bytes, checksum: d35fd8b618bd782bdff6ef801dfc68ef (MD5) giovanna 2.pdf: 128634 bytes, checksum: e25d780ccb5d47babf4f4c421249646b (MD5) Silva et al 2016 J Psych Research.pdf: 747242 bytes, checksum: 98e17c2c97366c098d5343dd88ec3b32 (MD5) Previous issue date: 2016-02-24 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES# #2075167498588264571# #600 Depression is a serious disorder that causes major impairments to the individual and may affect general functioning, familial relations, social and occupational activities. Despite its high prevalence (worldwide and in the Brazilian population) and of the proved effectiveness of psychotherapy as a treatment modality, individuals who suffer from Depression frequently do not receive proper psychotherapeutic care due to the several structural complexities of the basic health systems. In addition, other characteristics, such as comorbidities (personality disorders included) may make the clinical improvement of these patients more difficult. Thus, it is crucial that psychotherapy strategies that may be applied to the public health system are identified and effectively proved in terms of biochemical and psychological measures. The general objective of this thesis is to evaluate general suffering, symptom distress, interpersonal relations, and social role performance accordingly to the presence of personality disorders. Moreover, it aims to verify the effectiveness of two brief psychodynamic and cognitive-behavioral psychotherapy models through the evaluation instruments and biochemical markers. The first work sought to associate inflammatory biomarkers (IL-6 and TNF-α) with the remission of depressive symptoms in the supportive-expressive dynamic psychotherapy (n=46). The evaluation of depressive symptoms was carried out through the Outcome Questionnaire-45 (OQ-45) and the Beck Depression Inventory-II (BDI). Results demonstrate the effectiveness of psychotherapy in reducing inflammatory biomarkers (p

Objective To evaluate the prevalence of leisure-time physical activity and episodes of mood alteration in a population-based sample of adults, and its relation with gender. Method This is a cross-sectional population-based study with young adults aged between 18 and 35 years old. Sample selection was performed by clusters. The practice of physical activity was evaluated through the International Physical Activity Questionnaire (IPAQ), whereas mood disorders were evaluated using a short structured diagnostic interview—the Mini International Neuropsychiatric Interview (MINI) for DSM-IV and ICD-10 psychiatric disorders. Limitation Causal inferences are limited due the study׳s design. Results Sample consisted of 1953 young adults. The prevalence of leisure-time physical activity and of depressive episodes in the total sample was 25.3% and 17.2%, respectively. The prevalence of activity amongst men was 1.18 (CI 95% 1.18–1.32) times higher than in the women׳s group, whereas depression was 1.87 (CI 95% 1.41–2.47) times more prevalent amongst women than men. The prevalence of physical activity was not different between women ( p =0.287), nor between men ( p =0.895) regarding the presence of mania/hypomania episode. Conclusion The prevalence of physical activity and depression was different concerning gender. The prevalence of physical activity is lower amongst women, whereas the prevalence of depression is higher amongst women when compared to men.

Background Maternal depression may be a risk factor for childhood trauma (CT), with resultant offspring development of mood disorders (MD) in adult life. Objective To verify the relationship between maternal depression (as a risk factor for childhood trauma) and mood disorders in young adults. Methods The sample was composed of 164 young adults and their mothers. Maternal depression was identified through the Mini International Neuropsychiatric Interview (M.I.N.I.). Mood Disorders in the young adults were confirmed with the Structured Interview for the DSM-IV (SCID), whereas the CT was evaluated using the Childhood Trauma Questionnaire (CTQ). Results In the group of young adults with MD, individuals who had depressed mothers presented higher mean scores of CT in comparison to the ones who did not have mothers with Depression (p < 0.005). Childhood trauma was also associated with lower social classes (p < 0.005). In the group of young adults without MD, the only variable that was associated with CT was the young adult’s (not) current work (p < 0.005). Discussion Maternal depression was considered to be a risk factor for CT and MD in young adults. Thus, preventing and treating maternal psychiatric disorders may diminish the risk of offspring childhood trauma, and, consequently, avoid negative effects in the offspring’s adult life. Contexto Depressão materna pode ser um fator de risco para trauma na infância (TI), com consequente desenvolvimento de transtornos de humor (TH) em seus filhos na vida adulta. Objetivo Verificar a relação entre depressão materna (como fator de risco para TI) e TH em jovens. Métodos A amostra foi composta de 164 jovens adultos e suas mães. A depressão materna foi identificada por meio do Mini International Neuropsychiatric Interview (M.I.N.I.). Transtornos de humor nos jovens foram confirmados pela entrevista estruturada para o DSM-IV (SCID), enquanto o TI foi avaliado pelo Questionário de Trauma na Infância (CTQ). Resultados No grupo de jovens com TH, indivíduos que tiveram mães deprimidas apresentaram escores médios de TI mais altos em comparação aos que não tinham mães com depressão (p < 0,05). Trauma na infância também esteve associado com classes sociais desfavorecidas (p < 0,05). No grupo de jovens sem TH, a única variável associada ao TI foi o (não) trabalho do jovem (p < 0,05). Conclusões A depressão materna foi considerada fator de risco para TI e TH nos jovens. Portanto, prevenir e tratar transtornos psiquiátricos maternos pode diminuir o risco de trauma infantil no filho e, por consequência, evitar efeitos negativos na vida adulta da prole.

Suicide is among the main causes of death of people aged between 15 and 44 years old. Childhood trauma is an important risk factor for suicide. Hence, the objective of this study was to verify the relationship between childhood trauma and current suicide risk (suicidal behavior and ideation) in individuals aged 14-35 years, in the city of Pelotas, Brazil. This is a cross-sectional, population-based study. Sample selection was performed by clusters. Suicide risk was evaluated using the Mini International Neuropsychiatric Interview (MINI) and Childhood trauma was assessed with the Childhood Trauma Questionnaire (CTQ). Moreover, the participants responded to a questionnaire concerning socioeconomic status, work, and substance use. The sample was composed of 1,380 individuals. The prevalence of suicide risk was 11.5%. The prevalence figures of childhood trauma were 15.2% (emotional neglect), 13.5% (physical neglect), 7.6% (sexual abuse), 10.1% (physical abuse), and 13.8% (emotional abuse). Suicide risk was associated (p

There are scarce follow-up studies evaluating the role of psychoeducation in the treatment of bipolar disorder, especially in a young sample, with a recent diagnosis and that probably received a few previous interventions. This was a randomized clinical trial with young adults aged 18-29 years, who had been diagnosed with bipolar disorder through the Structured Clinical Interview for DSM (SCID). The evaluation of quality of life was carried out using the Medical Outcomes Survey 36-Item Short-Form Health Survey (MOS SF-36). All participants were randomized into two groups: combined intervention (psychoeducation plus medication) and treatment-as-usual (medication). The sample consisted of 61 patients divided in two groups (29 usual treatment; 32 combined intervention). The quality of life domains did not reveal statistically significant differences when comparing baseline, post-intervention and 6-month follow-up evaluations, which indicates that there is no difference between combined intervention and usual intervention regarding quality of life improvement. Both groups presented improvements in quality of life domains, except General Health and Bodily Pain, at post-intervention. Moreover, this improvement persisted at 6-month follow-up, except for the Role Physical Health domain, which remained reduced. Combined Psychoeducation plus pharmacological intervention is so effective in improving quality of life perception as it is pharmacological only intervention.

Made available in DSpace on 2016-03-22T17:26:31Z (GMT). No. of bitstreams: 1 Giovanna Del Grande da Silva.pdf: 628517 bytes, checksum: 06b68a3889aadb6b7efa26d51ccf7dee (MD5) Previous issue date: 2011-02-28 Background: Caregiver burden has been associated both with the caregiver s need for support and information, and the caregiver s mental disorders. However, there are not quantitative studies in Brazil regarding caregiver burden in a community sample. Methods: This is a cross-sectional study, nested in a population-based crosssectional study with youngsters, conducted in the city of Pelotas, Brazil. The caregivers (n=187) responded to the Burden Interview (BI), to the M.I.N.I. and to the CAGE, and they also answered questions regarding socioeconomic variables. Results: Caregiver burden was associated to the following variables: young person s low schooling, being the caregiver of young people with Depression Disorder and Bipolar Disorder, and caregiver s Axis I disorders. Also, there is an indication that alcohol abuse/dependence and caregiver burden are related. Limitations: Since there is no data previous to the young people diagnosis (Bipolar and Depressive Disorder), it is not possible to conclude neither that the burden is a contributing factor for the caregiver s Axis I Disorders (and the alcohol abuse) nor if these factors have lead to the caregiver burden. Conclusions: Caregivers are affected by the young people s disorder even before the diagnosis. Such impact may lead to serious impairments provoked by the burden and its correlate factors. These findings should contribute to further studies and to the creation of intervention strategies targeting the informal caregiver Keywords: Burden, Caregiver, Depression, Bipolar Disorder O Transtorno de Humor Bipolar (THB) é um transtorno crônico e recorrente e causa um grande prejuízo na vida do indivíduo. Sua característica básica é a oscilação de humor entre episódios de euforia (mania/hipomania) e depressão, podendo estes apresentar-se distintos ou mistos. Da mesma forma, outros sintomas podem estar associados e causar um impacto ainda maior, como irritabilidade, agressividade, auto-estima inflada, comportamentos inadequados e/ou de risco, tais como: compras exageradas, uso/abuso de substâncias, dirigir em alta velocidade, comportamento hipersexualizado; entre outros. A alta prevalência de suicídios e/ou tentativas ao longo da vida também é um fator de extrema importância no THB, sendo este associado à sobrecarga do cuidador em alguns estudos. A estimativa com relação ao desenvolvimento do transtorno bipolar por volta dos 20 anos de idade é de que o indivíduo perderá cerca de nove anos em sua expectativa média de vida, 12 anos de saúde normal e 14 anos de trabalho (Scott, 1995) o que demonstra o profundo impacto do transtorno sobre a qualidade de vida do indivíduo e seus familiares. A presente investigação tem como foco principal os cuidadores informais (não profissionais) de jovens com Transtorno Bipolar, caracterizando-se o cuidador como a pessoa que passa a maior parte do tempo com o jovem e, portanto está mais exposta às características do transtorno. Outros fatores como a sobrecarga financeira também serão avaliados. Os cuidadores serão os pais ou companheiro(a) do jovem e, portanto é pertinente investigar o impacto do transtorno no âmbito familiar. O presente trabalho contempla também a identificação da sobrecarga em cuidadores de indivíduos com Depressão Unipolar. A motivação para tal objetivo consiste nos resultados de alguns estudos que indicam que o Transtorno Bipolar muitas vezes é diagnosticado erroneamente como Transtorno Depressivo, o que pode levar a atrasos e prejuízos no tratamento correto. Além disso, a Depressão Unipolar é um transtorno recorrente que 9 comprovadamente exerce um grande impacto sobre o indivíduo e a família, principalmente devido ao aspecto agudo do episódio. O Transtorno Bipolar, em contrapartida, tem um aspecto crônico e ocasiona prejuízos interpessoais e ocupacionais mesmo nos períodos de eutimia. Por conseguinte, tanto os cuidadores de indivíduos com Transtorno Depressivo como os de indivíduos com Transtorno Bipolar estão expostos a sobrecarga e podem apresentar prejuízos em decorrência desta. Vários estudos realizados sobre Transtorno Bipolar e família, têm como foco o nível de sobrecarga dos familiares cuidadores, alguns destes em comparação com familiares de indivíduos com transtorno depressivo maior (TDM). Porém, no Brasil este é um aspecto muito pouco explorado. Desta forma, este estudo visa identificar os níveis de sobrecarga nos cuidadores de jovens com Transtorno do Humor Bipolar e nos cuidadores de jovens com Transtorno Depressivo Maior para, assim, fornecer subsídios para futuros estudos e embasar estratégias de intervenção para essa população

OBJECTIVE: To estimate the prevalence of depression and correlate clinical and demographic characteristics in pregnant women assisted by the public health system in the city of Pelotas, RS, Brazil. METHOD: We performed a cross-sectional study focused on pregnant women assisted by the public health service. The Edinburgh Postnatal Depression Scale (EPDS) was used to screen for depression. RESULTS: In a sample of 1,264 pregnant women aged 12-46 years, 21.1% (n = 255) presented a depressive episode during pregnancy. The presence of depression was associated with older age, lower education, lack of a cohabiting partner, not being primiparous, planned pregnancy, abortion thoughts, psychological or psychiatric treatment, smoking and alcohol consumption during pregnancy, and stressful events. CONCLUSION: Pregnant women assisted by the Brazilian public health system presented a high prevalence of depression. Psychiatric history, lack of support, and stressful events increase the probability of antenatal depression. OBJETIVO: Estimar a prevalência de depressão, bem como fatores clínicos e características demográficas associados em grávidas assistidas por meio do sistema público de saúde da cidade de Pelotas, RS, Brasil. MÉTODO: Foi realizado um estudo transversal tendo como população-alvo as grávidas assistidas pelo sistema público de saúde. Para o rastreio da depressão foi utilizada a Edinburgh Postnatal Depression Scale. RESULTADOS: Em uma amostra de 1.264 mulheres grávidas com idade de 12 a 46 anos, 21,1% (n = 255) apresentaram episodio depressivo durante a gravidez. A presença de depressão foi associada com ter mais idade, menor grau educacional, não morar com companheiro, não ser primigesta, ter planejado a gestação, idealizar o aborto, ter feito tratamento psicológico ou psiquiátrico, consumir tabaco e/ou álcool durante a gravidez e ter sofrido algum evento estressor. CONCLUSÃO: As mulheres grávidas acompanhadas pelo sistema público de saúde apresentaram alta prevalência de depressão. História psiquiátrica, baixo suporte e eventos estressores aumentam a probabilidade de depressão no período pré-parto.

As atividades de prática em cursos de licenciatura são fundamentais na formação dosfuturos professores. Para as habilitações oferecidas na modalidade a distância, casosejam adotados procedimentos e instrumentos usados em cursos presenciais, a dispersãogeográfica dos alunos representa um fator que poderá dificultar o processo desupervisão por parte dos professores. Diante da crescente oferta de cursos delicenciatura, seja por indução resultante de políticas públicas ou pela iniciativa deinstituições de ensino superior, considera-se oportuno buscar alternativas tecnológicas epedagógicas para apoiar o desenvolvimento e a supervisão das atividades de prática. Emnossas pesquisas consideramos um framework para a aprendizagem com mobilidade,com forte ênfase em um domínio pedagógico destinado a orientar o uso de recursostelemáticos. Para delimitar o contexto do trabalho, utilizamos como objeto deinvestigação uma oferta em andamento do curso de Licenciatura em Computação. Coma adoção de dispositivos computacionais móveis portáteis, em conjunto com serviços eaplicativos para a produção, organização e distribuição de conteúdos em formatomultimídia, alunos e professores dos cursos de licenciatura poderão construir novosconhecimentos num ambiente virtual de aprendizagem com mobilidade.

Submitted by Cristiane Chim (cristiane.chim@ucpel.edu.br) on 2019-05-20T12:11:01Z No. of bitstreams: 1 Mariana Carret Soares.pdf: 2646448 bytes, checksum: 703d8b3921b26f5fd34c541875f02232 (MD5) Made available in DSpace on 2019-05-20T12:11:01Z (GMT). No. of bitstreams: 1 Mariana Carret Soares.pdf: 2646448 bytes, checksum: 703d8b3921b26f5fd34c541875f02232 (MD5) Previous issue date: 2018-12-12 Introduction: Major depression is a disabling and high prevalence disorder and is associated with reduced quality of life, disability in social and personal relationships and impaired functionality of working life. Brief models of psychotherapy have proved effective and have in recent years been an increasing interest and commitment to the integration of this psychotherapy model with other mental health services in the context of primary care. Aims: The aim of this thesis is to evaluate the efficacy of two brief psychotherapy models for depression on the therapeutic progress and on the improvement of depressive symptoms at postintervention. As well as, evaluated the impact of these two brief psychotherapy models on patient’s functionality and on depressive and anxious symptomatology at twelve-month followup. Method: A randomized clinical trial was conducted with individuals of 18-60 tears of age who sought for psychotherapeutic treatment at the Clinic of Research and Extension in Mental Health of the Catholic University of Pelotas. The diagnose was conduct according to the Mini International Neuropsychiatric Interview – Plus (MINI-PLUS). Two models of psychotherapy were used: Supportive-Expressive dynamic psychotherapy (SEDP) (18 sessions) and Cognitive Behavior Therapy (CBT) (16 sessions). Therapeutic progress was evaluated through Outcome Questionnaire 45 (OQ-45) and the depressive symptoms through Beck depression inventory-II (BDI-II). Patients functionality was evaluated through Functional Assessment Short Test (FAST) and anxious symptoms through Beck Anxiety Inventory (BAI). Participants were evaluated at baseline, post-intervention (last session), at six-month and twelve-month followup. Results: Both models were effective in BDI-II improvement from baseline to post-intervention at CBT (p £ 0.05; Cohens’d = 1.27) and OQ-45 (p £ 0.05; Cohens’d = 1.42), and at SEDP group in BDI-II (p £ 0.05; Cohens’d = 1.09) and OQ-45 (p £ 0.05; Cohens’d = 1.13), no differences were found between the models for BDI-II (IC = -0.19 a 0.52) and OQ-45 (IC= -0.14 a 0.57). There was a significant increase in patient’s functionality in both models from baseline to twelve-month follow-up (F = 22.981, p < 0.001), in depressive symptoms (F = 50.054; p < 0.001) and anxious symptoms (F = 21.036; p < 0.001). there were no differences between models in all evaluation’s times. 9 Conclusion: Both models of psychotherapy were effective in improving depressive symptoms during the treatment for major depressive disorder, as well as had an impact in improving patient functionality and depressive and anxious symptomatology a year after its end. Introdução: A depressão maior é um transtorno incapacitante, bastante prevalente e está associada à redução da qualidade de vida, deficiência nas relações sociais e pessoais e prejuízo na funcionalidade da vida profissional. Os modelos breves de psicoterapia têm se mostrado eficazes, tendo nos últimos anos havido um crescente interesse e compromisso com a integração desses modelos com outros serviços de saúde mental no contexto de cuidados primários. Objetivos: Esta tese tem como objetivo avaliar a eficácia de dois modelos de psicoterapia breve para depressão no progresso terapêutico e na melhora de sintomas depressivos após a intervenção. Como também, avaliar o impacto destes dois modelos de psicoterapia breve na funcionalidade do paciente e na sintomatologia depressiva e ansiosa no follow-up de dozemeses. Método: Foi realizado um ensaio clínico randomizado com 247 indivíduos de 18 a 60 anos de idade que buscaram por tratamento psicoterapêutico no Ambulatório de Pesquisa e Extensão em Saúde Mental da Universidade Católica de Pelotas. O diagnóstico de transtorno depressivo maior foi realizado através da Mini International Neuropsychiatric Interview – PLUS (MINIPLUS). Os modelos de psicoterapia utilizados foram: Psicoterapia Dinâmica Suportiva- Expressiva (PDSE) (18 sessões) e Terapia Cognitiva-Comportamental (TCC) (16 sessões). O progresso terapêutico foi avaliado através do instrumento Outcome Questionnaire-45 (OQ-45) e os sintomas depressivos através do Beck Depression Inventory-II (BDI-II). A funcionalidade do paciente foi avaliada através da Functional Assesment Short Test (FAST) e a sintomatologia ansiosa através do Beck Anxiety Inventory (BAI). Participantes foram avaliados no início, durante o tratamento e após a intervenção (última sessão), como também no follow-up de seis e doze-meses. Resultados: Ambos modelos foram eficazes na melhora do BDI-II do baseline ao pósintervenção na TCC (p £ 0.05; Cohens’d = 1.27) e OQ-45 (p £ 0.05; Cohens’d = 1.42), e na PDSE no BDI-II (p £ 0.05; Cohens’d = 1.09) e OQ-45 (p £ 0.05; Cohens’d = 1.13), sem diferença entre os modelos para o BDI-II (IC = -0.19 a 0.52) e OQ-45 (IC= -0.14 a 0.57). Houve uma melhora na funcionalidade em ambos modelos do baseline ao follow-up de doze-meses (F = 22.981, p < 0.001), nos sintomas depressivos (F = 50.054; p < 0.001) e sintomas ansiosos (F = 21.036; p < 0.001). Não houve diferenças entre os modelos em todos os tempos de avaliação. Conclusão: Os dados demonstram que ambos os modelos de psicoterapia foram eficazes na melhora da autoavalição do progresso terapêutico e dos sintomas depressivos durante o 7 tratamento para o transtorno depressivo maior, como também tiveram impacto na melhora da funcionalidade e da sintomatologia ansiosa e depressiva um ano após o término.