94 results on '"Giovanni Fiori"'
Search Results
2. Unveiling the microRNA landscape in pancreatic ductal adenocarcinoma patients and cancer cell models
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Grazia Fenu, Carmen Griñán-Lisón, Andrea Pisano, Aitor González-Titos, Cristiano Farace, Giovanni Fiorito, Federica Etzi, Teresa Perra, Angela Sabalic, Belén Toledo, Macarena Perán, Maria Giuliana Solinas, Alberto Porcu, Juan Antonio Marchal, and Roberto Madeddu
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PDAC ,MiRNA ,CSC ,Biomarkers ,Meta-analysis ,Serum ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) poses a significant challenge due to late-stage diagnoses resulting from nonspecific early symptoms and the absence of early diagnostic biomarkers. MicroRNAs (miRNAs) play a crucial role in regulating diverse biological processes, and their abnormal expression is observed in various diseases, including cancer. Cancer stem cells (CSCs) are thought to act as a driving force in PDAC spread and recurrence. In pursuing the goal of unravelling the complexities of PDAC and its underlying molecular mechanisms, our study aimed to identify PDAC-associated miRNAs and relate them to disease progression, focusing on their involvement in various PDAC stages in patients and in reliable in vitro models, including pancreatic CSC (PaCSC) models. Methods The miRNA profiling datasets of serum and solid biopsies of PDAC patients deposited in GEO DataSets were analyzed by REML-based meta-analysis. The panel was then investigated by Real Time PCR in serum and solid biopsies of 37 PDAC patients enrolled in the study, as well as on BxPC-3 and AsPC-1 PDAC cell lines. We extended our focus towards a possible role of PDAC-associated miRNAs in the CSC phenotype, by inducing CSC-enriched pancreatospheres from BxPC-3 and AsPC-1 PDAC cell lines and performed differential miRNA expression analysis between PaCSCs and monolayer-grown PDAC cell lines. Results Meta-analysis showed differentially expressed miRNAs in blood samples and cancerous tissues of PDAC patients, allowing the identification of a panel of 9 PDAC-associated miRNAs. The results emerging from our patients fully confirmed the meta-analysis for the majority of miRNAs under investigation. In vitro tasks confirmed the aberrant expression of the panel of PDAC-associated miRNAs, with a dramatic dysregulation in PaCSC models. Notably, PaCSCs have shown significant overexpression of miR-4486, miR-216a-5p, and miR-216b-5p compared to PDAC cell lines, suggesting the recruitment of such miRNAs in stemness-related molecular mechanisms. Globally, our results showed a dual behaviour of miR-216a-5p and miR-216b-5p in PDAC while miR-4486, miR-361-3p, miR-125a-5p, miR-320d expression changes during the disease suggest they could promote PDAC initiation and progression. Conclusions This study contributed to an enhanced comprehension of the role of miRNAs in the development and progression of PDAC, shedding new light on the miRNA landscape in PDAC and its intricate interplay with CSCs, and providing specific insights useful in the development of miRNA-based diagnostic biomarkers and therapeutic targets.
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- 2024
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3. Effects of protein restriction on insulin-like growth factor (IGF)-1 in men with prostate cancer: results from a randomized clinical trial
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Maria L. Cagigas, Giovanni Fiorito, Beatrice Bertozzi, Andrius Masedunskas, Edda Cava, Francesco Spelta, Nicola Veronese, Valeria Tosti, Gayathiri Rajakumar, Tiana Pelaia, Arnold D. Bullock, Robert S. Figenshau, Gerald L. Andriole, and Luigi Fontana
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Therapeutics. Pharmacology ,RM1-950 - Abstract
Abstract Background Insulin-like growth factor (IGF)-1 and its binding proteins are important in cancer growth, especially in prostate cancer. Observational studies suggest that protein restriction can lower IGF-1 levels. However, it is unclear whether an isocaloric protein-restricted diet affects IGF-1 and IGFBPs in men with prostate cancer. Methods In this academic, single-center, parallel-group, prospective, randomized, open-label, blinded end-point trial, 38 consenting overweight (BMI 30.5 ± 5.5 kg/m2) men with localized prostate cancer, aged 43–72 years, were randomized (1:1) with permuted blocks to 4–6 weeks of customized isocaloric PR diets (0.8 g protein/kg lean body mass) or their usual diet. Biomarkers influencing cancer biology, including serum IGF-1 and its binding proteins were measured longitudinally. Results Contrary to our hypothesis, feeding individuals an isocaloric protein-restricted diet did not result in a significant reduction in serum IGF-1. Moreover, there was no observed increase in serum IGFBP-1 or IGFBP-3 concentration. Conclusion These findings demonstrate that protein restriction without calorie restriction does not reduce serum IGF-1 concentration or increase IGFBP-1 and IGFBP-3 in men with localized prostate cancer. Further research is needed to identify dietary interventions for safely and effectively reducing IGF-1 in this patient group.
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- 2024
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4. Metaproteomic portrait of the healthy human gut microbiota
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Alessandro Tanca, Antonio Palomba, Giovanni Fiorito, Marcello Abbondio, Daniela Pagnozzi, and Sergio Uzzau
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Microbial ecology ,QR100-130 - Abstract
Abstract Gut metaproteomics can provide direct evidence of microbial functions actively expressed in the colonic environments, contributing to clarify the role of the gut microbiota in human physiology. In this study, we re-analyzed 10 fecal metaproteomics datasets of healthy individuals from different continents and countries, with the aim of identifying stable and variable gut microbial functions and defining the contribution of specific bacterial taxa to the main metabolic pathways. The “core” metaproteome included 182 microbial functions and 83 pathways that were identified in all individuals analyzed. Several enzymes involved in glucose and pyruvate metabolism, along with glutamate dehydrogenase, acetate kinase, elongation factors G and Tu and DnaK, were the proteins with the lowest abundance variability in the cohorts under study. On the contrary, proteins involved in chemotaxis, response to stress and cell adhesion were among the most variable functions. Random-effect meta-analysis of correlation trends between taxa, functions and pathways revealed key ecological and molecular associations within the gut microbiota. The contribution of specific bacterial taxa to the main biological processes was also investigated, finding that Faecalibacterium is the most stable genus and the top contributor to anti-inflammatory butyrate production in the healthy gut microbiota. Active production of other mucosal immunomodulators facilitating host tolerance was observed, including Roseburia flagellin and lipopolysaccharide biosynthetic enzymes expressed by members of Bacteroidota. Our study provides a detailed picture of the healthy human gut microbiota, contributing to unveil its functional mechanisms and its relationship with nutrition, immunity, and environmental stressors.
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- 2024
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5. The increasing need for a new Italian legislation to facilitate execution of observational studies assuring ethics and the highest standards of scientific and methodological quality. Editorial
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Carlo, Petrini, Giovanni, Fiori, Gualberto, Gussoni, Sara, Cazzaniga, Giovannni, Corrao, Valeria, Lovato, Dario, Manfellotto, Francesca, Mastromauro, and Alessandro, Mugelli
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Observational Studies as Topic ,Italy ,Humans - Published
- 2020
6. Assessing Water Demand of Green Roofs Under Variants of Climate Change Scenarios
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Daniele Bocchiola, Andrea Giovanni Mainini, Matteo Paolo Giovanni Fiori, Alberto Speroni, Juan Diego Blanco Cadena, and Tiziana Poli
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Resource (biology) ,business.industry ,Environmental resource management ,Green roof ,Climate change ,Sustainable water management ,Convention ,Water balance ,Political science ,Climate change scenario ,Urban heat island ,business ,Surface runoff - Abstract
Green roofs are a resource for the city: they mitigate pollution, decrease the urban heat island effect (UHI), and regulate storm runoff. Within a climate change scenario, green roofs might instead become an issue, and in particular, in mitigating UHI at mesoscale level. The aim of the contribution is to define the water balance and thus the water consumption of a typical green roof, considering its variation when immersed into different climate scenarios that took place in the past five years (Linked with the following research projects: (1) Research title: 2016, Fondazione Minoprio/Politecnico di Milano, Dipartimento ABC (ongoing), Research type: Convention, Responsible: Matteo Fiori. (2) Research title: 2018, Harpo Contract (ongoing), Research type: Funded by third parties, Responsible: Matteo Fiori. (3) Research title: 2018, Soprema Contract (ongoing), Research type: Funded by third parties, Responsible: Matteo Fiori. (4) Research title: 2018, ASSIMP T-dry Contract (ongoing), Research type: Funded by third parties, Responsible: Matteo Fiori).
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- 2020
7. A prototype of a stationary DA device to group apricot fruits in classes of homogeneous ripening
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S. Knieling, J. Rossier, Guglielmo Costa, S. Vidoni, Giovanni Fiori, Lorenzo Rocchi, N. Berthod, and S. Besse
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Absorbance ,Horticulture ,biology ,Homogeneous ,Flesh ,Ripening ,Titratable acid ,Cultivar ,biology.organism_classification ,Prunus armeniaca ,Mathematics ,Internal quality - Abstract
In apricot (Prunus armeniaca L.), fruit quality at consumption and shelf-life potential are strictly related to the ripening stage reached at harvest. As a result, definition of the optimal harvest time is a crucial issue and, nowadays, this is performed on the basis of fruit size, skin color and some internal quality traits, such as flesh firmness (FF), soluble solids content (SSC) and titratable acidity (TA), that are determined by standard techniques that require destruction of the fruit sample. Recently, extensive research has focused on the development of non-destructive visible/near-infrared spectroscopy (vis/NIRs) techniques that allow the ripening stage to be expressed as a new maturity index, called the index of “absorbance difference” (I(AD)). The I(AD) is used to establish, under field conditions, the optimal harvest time related to the ripening stage at harvest with a portable DA meter. More recently, a stationary DA machine prototype has been realized, allowing the grouping of fruits in classes of homogeneous ripening at the packing-house level. Preliminary results obtained with this prototype on some apricot cultivars grown in Valais (Sion, Switzerland) are reported. The results obtained showed that the I(AD) values obtained with the stationary DA allow fruit to be grouped according to their ripening stage. The data were comparable with those obtained with a portable DA meter, and correlate with standard internal quality traits.
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- 2018
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8. Exogenous application of plant growth regulators enhances color and anthocyanin content of cherry fruits
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Massimo Noferini, S. Vidoni, Guglielmo Costa, E. Bonora, Giovanni Fiori, E. G. L. Nagpala, and L. Piccinini
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0106 biological sciences ,Plant growth ,Plant composition ,04 agricultural and veterinary sciences ,Horticulture ,01 natural sciences ,chemistry.chemical_compound ,chemistry ,Soluble solids ,Anthocyanin ,Botany ,040103 agronomy & agriculture ,Postharvest ,0401 agriculture, forestry, and fisheries ,Crop quality ,Abscisic acid ,Chemical composition ,010606 plant biology & botany - Published
- 2017
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9. Satisfaction with chronic obstructive pulmonary disease treatment: results from a multicenter, observational study
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Marco Contoli, Paola Rogliani, Fabiano Di Marco, Fulvio Braido, Angelo G. Corsico, Christian A. Amici, Roberto Piro, Riccardo Sarzani, Patrizia Lessi, Carla Scognamillo, Nicola Scichilone, Pierachille Santus, Angelo Guido Corsico, Rita Raccanelli, Dejan Radovanovic, Erica Gini, Vincenzo Patella, Giovanni Florio, Silvia Garuti, Giacomo Forini, Alida Benfante, Giuseppe Fiorentino, Antonella Marotta, Fausta Alfano, Francesco Cavalli, Patrizia Ruggiero, Mauro Carone, Maria Aliani, Antonio Iannaccone, Alessandro Izzo, Biago Polla, Francesco Spannella, Claudio Micheletto, Rigoletta Vincenti, Laura Maugeri, Carlo Gulotta, Roberto Tazza, Luigi Di Re, Paolo Mimotti, Roberto Carbone, Rodolfo Riva, Giovanni Fiori, Stefano Viaggi, Alessandra Ori, Lucia Simoni, Christian Amici, Fabio Ferri, Barbara Roncari, Saide Sala, Francesca Trevisan, Nicole Lanci, Contoli M., Rogliani P., Di Marco F., Braido F., Corsico A.G., Amici C.A., Piro R., Sarzani R., Lessi P., Scognamillo C., Scichilone N., Santus P., Raccanelli R., Radovanovic D., Gini E., Patella V., Florio G., Garuti S., Forini G., Benfante A., Fiorentino G., Marotta A., Alfano F., Cavalli F., Ruggiero P., Carone M., Aliani M., Iannaccone A., Izzo A., Polla B., Spannella F., Micheletto C., Vincenti R., Maugeri L., Gulotta C., Tazza R., Di Re L., Mimotti P., Carbone R., Riva R., Fiori G., Viaggi S., Ori A., Simoni L., Amici C., Ferri F., Roncari B., Sala S., Trevisan F., and Lanci N.
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Pulmonary and Respiratory Medicine ,Male ,Chronic Obstructive ,medicine.medical_specialty ,COPD ,adherence ,treatment satisfaction ,Pulmonary disease ,Socio-culturale ,Treatment results ,Settore MED/10 - Malattie Dell'Apparato Respiratorio ,Outcome (game theory) ,Medication Adherence ,Pulmonary Disease ,03 medical and health sciences ,Pulmonary Disease, Chronic Obstructive ,0302 clinical medicine ,Surveys and Questionnaires ,Administration, Inhalation ,Settore MED/10 ,Medicine ,Humans ,Pharmacology (medical) ,030212 general & internal medicine ,Intensive care medicine ,Original Research ,Aged ,lcsh:RC705-779 ,adherence, COPD, treatment satisfaction ,business.industry ,lcsh:Diseases of the respiratory system ,Middle Aged ,Dyspnea ,Inhalation ,030228 respiratory system ,Italy ,Patient Satisfaction ,Administration ,Observational study ,Female ,business ,Follow-Up Studies - Abstract
Background: Understanding the level of patients’ satisfaction with treatment and its determinants have the potential to impact therapeutic management and clinical outcome in chronic conditions such as chronic obstructive pulmonary disease (COPD). Methods: A national, multicenter, longitudinal, observational study of COPD from 20 Italian pulmonary centers to explore patients’ satisfaction to treatment [assessed by the Treatment Satisfaction Questionnaire, 9 items (TSQM-9)] and association with clinical parameters [including dyspnea score, COPD Assessment Test (CAT) score, exacerbation rate], adherence to treatment [Morisky Medication-Taking Adherence Scale (MMAS-4)], illness perception [evaluated by Brief Illness Perception Questionnaire (B-IPQ)] in a 1-year follow up. Results: A total of 401 COPD patients were enrolled [69.4% group B Global Initiative for COPD (GOLD), considering 366 patients with available GOLD 2017 classification at enrollment]. At enrollment, satisfaction with treatment was moderate, being TSQM-9 mean scores for effectiveness 64.2 [95% confidence interval (CI) 62.5–65.9], for convenience 75.8 (95% CI 74.2–77.3), and for global satisfaction 65.7 (95% CI 64.0–67.4). Global satisfaction was negatively associated with disease perception (β = −0.4709, p Conclusions: The results of this real-life study showed that the patients’ satisfaction with treatments is only moderate in COPD. A high grade of patients’ satisfaction is associated mainly with a low perception of the disease, high adherence to treatment and lower level of dyspnea. Trial Registration: Clinicaltrials.gov identifier: NCT02689492 The reviews of this paper are available via the supplemental material section.
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- 2019
10. Regular Physical Activity Can Counteract LONG COVID Symptoms in Adults over 40
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Marco Centorbi, Giulia Di Martino, Carlo della Valle, Enzo Iuliano, Gloria Di Claudio, Amelia Mascioli, Giuseppe Calcagno, Alessandra di Cagno, Andrea Buonsenso, and Giovanni Fiorilli
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exercise ,fatigue ,distress ,pandemic ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Three years after the SARS-CoV-19 pandemic, a chronic post-COVID syndrome “LONG COVID” persists, causing fatigue and shortness of breath, along with distress, anxiety, and depression. Aim: To assess the impact of physical activity on the management and rehabilitation of LONG COVID, as well as to investigate the persistence of LONG COVID symptomatology in individuals over 40 years, beyond the pandemic. Methods: A total of 1004 participants (aged 53.45 ± 11.35) were recruited through an online snowball sampling strategy to complete a web-based survey. The following questionnaires were administered: Physical Activity Scale for Elderly (PASE), Shortness of Breath Questionnaire (SOBQ), Patient Health Questionnaire-9 item (PHQ-9), Generalized Anxiety Disorder 7-item (GAD-7), and Fatigue Scale for Motor and Cognitive Functions (FSMC). Results: Significant gender differences were discovered, with women reporting higher symptoms than men (p < 0.001). Significant age differences were also found, with participants under 55 showing higher values than those over 55 (p < 0.001). No significant differences were found between aerobic and mixed physical activity (p > 0.05) while significant results emerged between physical activity groups and the no activity group (p < 0.001). The low-frequency group reported higher symptoms than the high-frequency group (all ps < 0.001). Conclusion: Regardless of the type of physical activity performed, our survey identified the frequency of training as a crucial factor to overcome LONG COVID symptoms; the challenge lies in overcoming the difficulties due to the persistent feelings of inefficiency and fatigue typical of those who have contracted the infection.
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- 2024
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11. Use of the DAindexTM for monitoring fruit ripening evolution in A. chinensis to precisely assess harvesting time 'in planta'
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Serena Vidoni, Alessandro Ceccarelli, Guglielmo Costa, Giovanni Fiori, and Lorenzo Rocchi
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0106 biological sciences ,Soil Science ,Ripening ,04 agricultural and veterinary sciences ,Plant Science ,Horticulture ,Biology ,01 natural sciences ,Biochemistry ,Botany ,040103 agronomy & agriculture ,0401 agriculture, forestry, and fisheries ,Agronomy and Crop Science ,010606 plant biology & botany ,Food Science - Published
- 2016
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12. DAFL: NEW INNOVATIVE DEVICE TO MONITOR FRUIT RIPENING IN STORAGE
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Guglielmo Costa, Giovanni Fiori, S. Musacchi, S. Vidoni, Francesco Spinelli, Lorenzo Rocchi, Vidoni, S., Fiori, G., Rocchi, L., Spinelli, F., Musacchi, S., and Costa, G.
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Fruit quality ,Non-destructive ,Horticulture ,IAD ,Ripening ,Biology ,Difference absorbance fruit logger - Abstract
The ripening stage reached by the fruits at harvest is linked to the fruit quality traits at consumption; it influences the postharvest management affecting storage length and fruit disease susceptibility. As a consequence, the knowledge of the ripening stage at harvest becomes essential, as well as the monitoring of the fruit ripening changes during cold storage. The index of absorbance difference (IAD) can follow the fruit ripening along the supply chain starting in the orchard, provided by the DA-Meter, a non-destructive device operating in VIS-NIR wavelenghts, and during cold storage, with the DAFL (difference absorbance fruit logger) that measures automatically the IAD at fixed intervals. The DAFL remote devices are positioned on a given number of fruits kept in cold storage and the IAD values are transmitted by radio to a server. The real time monitoring of these values gives indication on the management of the fruit as related to the ripening during storage.
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- 2015
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13. A PREDICTIVE MODEL FOR THE DEFINITION OF HARVEST WINDOW AND YIELD OF PEACH FRUIT OF THE VARIETY 'ROYAL MAJESTIC®'
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Giovanni Fiori, Massimo Noferini, C. Kusch, L. Piccinini, E. Bonora, S. Vidoni, and Guglielmo Costa
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Plant development ,Horticulture ,Agronomy ,Yield (wine) ,Crop yield ,Window (computing) ,Mathematics - Published
- 2015
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14. Omega-3 Index as a Sport Biomarker: Implications for Cardiovascular Health, Injury Prevention, and Athletic Performance
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Alessandro Medoro, Andrea Buonsenso, Marco Centorbi, Giuseppe Calcagno, Giovanni Scapagnini, Giovanni Fiorilli, and Sergio Davinelli
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omega-3 polyunsaturated fatty acids ,EPA ,DHA ,dietary supplementation ,sports ,exercise ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
The composition of polyunsaturated fatty acids (PUFA) in the cell membrane plays a crucial role in cell signaling and function. Physical activity can induce shifts in PUFA metabolism, potentially altering their membrane composition. Given the multifaceted regulatory and structural roles of PUFA, training-related fluctuations in PUFA concentrations may impact health and athletic performance in both elite and non-elite athletes, highlighting the critical role of these fatty acids’ nutritional intake. The ω-3 index (O3I), a biomarker reflecting the proportion of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in red blood cell membranes, is considered a marker of cardiovascular risk, gaining increasing interest in sports medicine. Dietary interventions aimed at maintaining an optimal O3I may offer several benefits for elite and non-elite athletes, including cardiovascular health performance optimization, recovery, and injury prevention. Here, we discuss emerging evidence on the application of O3I in sports and physical exercise, highlighting its promising role as a biomarker in a wide range of sports practices.
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- 2024
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15. Assessing the Impact of Fencing on Postural Parameters: Observational Study Findings on Elite Athletes
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Giulia Di Martino, Marco Centorbi, Andrea Buonsenso, Giovanni Fiorilli, Carlo della Valle, Enzo Iuliano, Giuseppe Calcagno, and Alessandra di Cagno
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postural asymmetries ,postural control ,stabilometry ,postural tone ,elite fencers ,Sports ,GV557-1198.995 - Abstract
The aim of the study was to evaluate whether the static stabilometric parameters among elite fencers, were affected by prolonged, asymmetric training regimen. A sample of 26 elite fencers of both genders, aged 19.15 ± 2.24 years, practising one of the three disciplines foil, épée, or sabre, was recruited for the study. Anthropometric measurements including thigh and calf circumferences and postural assessment based on the weight distribution on a stabilimeter platform were performed. Postural tone, as indicated by measures such as sway length and sway area ratio was calculated.. No notable anthropometric asymmetries were detected within the examined group The weight distribution patterns on the support quadrants in static stabilometric measurements did not suggest clinically significant issues. There were no significant differences among subgroups based on gender and lower limb dominance for both anthropometric and stabilimeter variables. However, 30.8% of participants showed anomalies in postural tone (hypertonic and hypotonic condition). Five out of eight athletes found with abnormal postural tone were foil fencers, suggesting a potential discipline-specific effect. Individual adjustments were found in foil fencers. These findings provide insights into the potential effects of fencing training on postural parameters among elite athletes.
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- 2024
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16. New-onset and flares of psoriasis after COVID-19 infection or vaccination successfully treated with biologics: a case series
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Luigi Gargiulo, Luciano Ibba, Carlo A. Vignoli, Francesco Piscazzi, Andrea Cortese, Giovanni Fiorillo, Francesco Toso, Giulia Pavia, Mario Valenti, Jessica Avagliano, Alessandra Narcisi, and Antonio Costanzo
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Dermatology ,RL1-803 - Published
- 2023
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17. Safety of anti-IL-23 drugs in patients with moderate-to-severe plaque psoriasis and previous tuberculosis infection: a monocentric retrospective study
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Luciano Ibba, Luigi Gargiulo, Carlo Alberto Vignoli, Giovanni Fiorillo, Mario Valenti, Antonio Costanzo, and Alessandra Narcisi
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Dermatology ,RL1-803 - Published
- 2023
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18. Exploring the Effects of Corporate Governance on Voluntary Disclosure: An Explanatory Study on the Adoption of Integrated Report
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Giovanni Fiori, Maria Federica Izzo, and Francesca di Donato
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integrated reporting ,Gender diversity ,business.industry ,Corporate governance ,corporate governance ,05 social sciences ,Accounting ,Sample (statistics) ,050201 accounting ,Integrated reporting ,board of directors ,+framework%22"> ,framework Voluntary disclosure ,Probit model ,agency ,0502 economics and business ,Agency (sociology) ,Corporate social responsibility ,Business ,+framework%22">integrated reporting, corporate governance, board of directors, agency, signalling, ,framework signalling ,050203 business & management - Abstract
Purpose The chapter builds on the literature of Agency and Signalling Theories to analyse the corporate governance factors associated with the voluntary decision to prepare an Integrated Report according to the International Framework promoted by the IIRC. Methodology/approach The chapter is based on the results of a probit regression run with regard to a sample of 35 companies that joined the Pilot Programme in 2011 and 137 similar companies that did not. Findings The analysis of two samples of European companies reveals that adhesion to the IR Pilot Programme is positively related to the gender diversity and size of the board. Research limitations Further research is required in order to study the differences between listed and non-listed companies in terms of variables affecting the adoption of the Framework and to increase the time range of our study. In addition, it would be interesting to include other variables capturing different aspects other than corporate governance, since the decision to join the Programme, as the results of our analysis have shown, may also be influenced by other factors, such as strategy decisions and communication policies. Originality/value The chapter adds to the existing literature by showing the main governance characteristics that impact the decision to adhere to the IR Pilot Programme. It is also important to the existing literature regarding the role played by gender diversity in corporate governance mechanisms and CSR policies.
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- 2016
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19. The Influence of Corporate Governance on the Adoption of The Integrated Report: A first Study on IIRC Pilot Programme
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Maria Federica Izzo and Giovanni Fiori
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+Framework%22"> ,Framework Board of Directors ,business.industry ,Corporate governance ,05 social sciences ,Integrated Reporting ,Accounting ,050201 accounting ,Integrated reporting ,Key issues ,Signaling ,Voluntary disclosure ,Corporate Governance ,Agency, Signaling ,Agency ,0502 economics and business ,Pilot program ,Business ,Composition (language) ,050203 business & management ,Financial statement - Abstract
This chapter has three main aims. First, it discusses the concept of Integrated Report (IR) as a privileged instrument of companies’ voluntary disclosure practices that answers to the investors and regulators’ call for a greater focus on companies’ strategy, governance, future performance and risks, overcoming a great part of the traditional financial statement’s limitations. Second, it introduces key issues currently being debated relating to the IR Pilot Program and the main characteristics of the companies that decided to adhere to it. Finally, it shows some empirical first results about the corporate governance factors associated with the voluntary decision to prepare an Integrated Report according to the IR International Framework. In so doing the authors draw some conclusions about how Corporate Governance structure and mechanisms—such as legal environment, composition of the board of directors or ownership structure—are related to company’s disclosure policies and the decision to adopt Integrated Report.
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- 2016
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20. METHODS TO ASSESS FRUIT QUALITY FOCUSING ON NON-DESTRUCTIVE METHODS
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J. Rossier, S. Besse, Guglielmo Costa, N. Berthod, Giovanni Fiori, and Massimo Noferini
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Risk analysis (engineering) ,media_common.quotation_subject ,Non destructive ,Quality (business) ,Horticulture ,Mathematics ,media_common - Published
- 2012
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21. INNOVATIVE NON-DESTRUCTIVE DEVICE FOR FRUIT QUALITY ASSESSMENT
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E. Bonora, Guglielmo Costa, Massimo Noferini, and Giovanni Fiori
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Actinidia deliciosa ,Horticulture ,Actinidia chinensis ,biology ,Flesh ,Flavour ,Ripening ,Cultivar ,biology.organism_classification ,Pruning ,Aroma ,Mathematics - Abstract
Maturity at harvest greatly affects kiwifruit storage potential and quality at consumption: if fruits are picked too early, they undergo a precocious softening during storage, and do not reach full flavour and aroma when ripe. In Actinidia deliciosa, soluble solids content and dry matter has been proposed as maturity indexes. In Actinidia chinensis, the optimal harvest time is determined on the basis of flesh colour (Hue Angle= °H). In the last decade, non-destructive techniques, such as NIRs (Near Infrared Spectroscopy) have been used for evaluating kiwifruit quality. However, these devices require time consuming calibrations and they are used to measure the same parameters which are determined by traditional techniques (SSC; DM, °H). As a consequence, they do not give any added values as compared to the traditional methods to assess fruit quality. Recently, the University of Bologna patented innovative and simplified NIRs equipment (DA-Meter and Kiwi-Meter) which allows to define fruit maturity stage by means of an index based on the difference in absorbance between specific wavelengths (IDA). This index correlates with the main traditional parameters as well as with changes in flesh colour. In addition the availability of simple and portable instrument allow their use on the fruit attached to the trees to monitor the maturation and the ripening evolution, and determine the best cultural management practices (such as pruning, thinning, nutrition, etc) that allow to reduce the fruit ripening heterogeneity and simplify post-harvest management of the fruits. In the present work, results on different cultivars of Actinidia deliciosa and Actinidia chinensis are reported.
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- 2011
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22. EVALUATION OF PARENTAL GENOTYPES AS A TOOL FOR PLANNING THE MATING DESIGN IN KIWIFRUIT BREEDING PROGRAMS
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Guglielmo Costa, Giovanni Fiori, L. Piccinini, Raffaele Testolin, and Guido Cipriani
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Agronomy ,Mating design ,Horticulture ,Biology - Published
- 2011
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23. Methylation-based markers of aging and lifestyle-related factors and risk of breast cancer: a pooled analysis of four prospective studies
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Pierre-Antoine Dugué, Clara Bodelon, Felicia F. Chung, Hannah R. Brewer, Srikant Ambatipudi, Joshua N. Sampson, Cyrille Cuenin, Veronique Chajès, Isabelle Romieu, Giovanni Fiorito, Carlotta Sacerdote, Vittorio Krogh, Salvatore Panico, Rosario Tumino, Paolo Vineis, Silvia Polidoro, Laura Baglietto, Dallas English, Gianluca Severi, Graham G. Giles, Roger L. Milne, Zdenko Herceg, Montserrat Garcia-Closas, James M. Flanagan, and Melissa C. Southey
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Prospective study ,DNA methylation ,Epigenetic aging ,Lifestyle ,Breast cancer risk ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background DNA methylation in blood may reflect adverse exposures accumulated over the lifetime and could therefore provide potential improvements in the prediction of cancer risk. A substantial body of research has shown associations between epigenetic aging and risk of disease, including cancer. Here we aimed to study epigenetic measures of aging and lifestyle-related factors in association with risk of breast cancer. Methods Using data from four prospective case–control studies nested in three cohorts of European ancestry participants, including a total of 1,655 breast cancer cases, we calculated three methylation-based measures of lifestyle factors (body mass index [BMI], tobacco smoking and alcohol consumption) and seven measures of epigenetic aging (Horvath-based, Hannum-based, PhenoAge and GrimAge). All measures were regression-adjusted for their respective risk factors and expressed per standard deviation (SD). Odds ratios (OR) and 95% confidence intervals (CI) were calculated using conditional or unconditional logistic regression and pooled using fixed-effects meta-analysis. Subgroup analyses were conducted by age at blood draw, time from blood sample to diagnosis, oestrogen receptor-positivity status and tumour stage. Results None of the measures of epigenetic aging were associated with risk of breast cancer in the pooled analysis: Horvath ‘age acceleration’ (AA): OR per SD = 1.02, 95%CI: 0.95–1.10; AA-Hannum: OR = 1.03, 95%CI:0.95–1.12; PhenoAge: OR = 1.01, 95%CI: 0.94–1.09 and GrimAge: OR = 1.03, 95%CI: 0.94–1.12, in models adjusting for white blood cell proportions, body mass index, smoking and alcohol consumption. The BMI-adjusted predictor of BMI was associated with breast cancer risk, OR per SD = 1.09, 95%CI: 1.01–1.17. The results for the alcohol and smoking methylation-based predictors were consistent with a null association. Risk did not appear to substantially vary by age at blood draw, time to diagnosis or tumour characteristics. Conclusion We found no evidence that methylation-based measures of aging, smoking or alcohol consumption were associated with risk of breast cancer. A methylation-based marker of BMI was associated with risk and may provide insights into the underlying associations between BMI and breast cancer.
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- 2022
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24. A novel type of seaweed extract as a natural alternative to the use of iron chelates in strawberry production
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Giovanni Fiori, Mattia Sprocatti, Guglielmo Costa, Francesco Spinelli, Massimo Noferini, F. Spinelli, G. Fiori, M. Noferini, M. Sprocatti, and G. Costa
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Chlorosis ,Vegetative reproduction ,PLANT BIOSTIMULANT ,RHIZOSPHERE ,Horticulture ,Biology ,Photosynthesis ,Fragaria ,chemistry.chemical_compound ,chemistry ,SUSTAINABLE HORTICULTURE ,Chlorophyll ,Shoot ,Dry matter ,SOIL AMENDMENT ,Alginic acid - Abstract
The new generation of seaweed extracts, such as Actiwave®, may represent a promising strategy to reduce the use of phytochemicals in agriculture. Actiwave® is a metabolic enhancer derived by the algae Ascophillum nodosum, but differently from some older seaweed extracts, it has a constant and balanced formulation containing kahydrin, alginic acid and betaines which synergistically contribute to the efficacy of the product. Actiwave® has been proposed to increase the mineral nutrient uptake and the abiotic stress tolerance. The aim of this work was to evaluate, under a multidisciplinary approach, the effect of the biostimulant on the vegetative and productive performances of strawberry plants grown on a lime inducing iron chlorosis substrate. This biostimulant increased the vegetative growth (10%), the leaf chlorophyll content (11%), the stomata density (6.5%), the photosynthetic rate and the fruit production (27%) and berry weight. The most significant result was the increase of the plant biomass: the shoot dry matter was increased up to 27% and root dry matter up to 76%. Finally, preliminary experiments showed that Actiwave® positively influenced also the root-associated microbial biocoenosis. These results are discussed in relation to the physiological and ecological mechanisms proposed to explain the beneficial effects of this seaweed extract. Finally, the effects of Actiwave® and sequestrene were significantly similar, thus showing that this biostimulant may represent an environmental-friendly substitute of the iron chelates.
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- 2010
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25. ESTABLISHMENT OF THE OPTIMAL HARVEST TIME IN APRICOT ('ORANGERED' AND 'BERGAROUGE') BY MEANS OF A NEW INDEX BASED ON VIS SPECTROSCOPY
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Giovanni Fiori, Guglielmo Costa, Vanina Ziosi, J. Rossier, N. Berthod, and Massimo Noferini
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biology ,Flesh ,Rosaceae ,Harvest time ,food and beverages ,Ripening ,Horticulture ,biology.organism_classification ,Prunus armeniaca ,Absorbance ,Geography ,Cultivar ,Fruit tree - Abstract
In apricot fruit (Prunus armeniaca L.), establishing the optimal harvest time is crucial since fruit quality and shelf-life potential are closely related to the ripening stage at harvest. In order to develop a non-destructive index for monitoring the progression of ripening in apricot, the difference in absorbance between two wavelengths near the chlorophyll-a absorption peak (670 and 720 nm; Index of Absorbance Difference, I AD ) was related to the time course of changes in fruit quality parameters (flesh firmness, soluble solids content, flesh elasticity) occurring during ripening. Four-year trials on two cultivars ('OrangeRed' and 'Bergarouge') showed that the I AD was able to segregate fruits according to their ripening stage. Moreover, the index value corresponding to the optimal harvest time remained constant in different years, independently of quality parameters (soluble solids content, flesh firmness or elasticity). Fruit graded according the I AD also showed different consumer acceptance, the fruit with the lowest index score being the most appreciated.
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- 2010
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26. A new index based on vis spectroscopy to characterize the progression of ripening in peach fruit
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Giovanni Fiori, Livio Trainotti, Vanina Ziosi, Giorgio Casadoro, Massimo Noferini, Alice Tadiello, and Guglielmo Costa
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RESOLVED REFLECTANCE SPECTROSCOPY, NEAR-INFRARED SPECTROSCOPY, NIR SPECTROSCOPY, GENE-EXPRESSION, APPLE FRUIT, NECTARINES, HARVEST, QUALITY, CHLOROPHYLL, FIRMNESS ,NEAR-INFRARED SPECTROSCOPY ,Ethylene ,APPLE FRUIT ,HARVEST ,Titratable acid ,Horticulture ,NIR SPECTROSCOPY ,Prunus ,chemistry.chemical_compound ,RESOLVED REFLECTANCE SPECTROSCOPY ,QUALITY ,Cultivar ,GENE-EXPRESSION ,Flesh ,FIRMNESS ,food and beverages ,Ripening ,NECTARINES ,CHLOROPHYLL ,chemistry ,Postharvest ,Climacteric ,Agronomy and Crop Science ,Food Science - Abstract
In peach fruit ( Prunus persica L. Batsch), establishing the optimal harvest time is a crucial issue, since fruit shelf-life potential and quality are closely related to the ripening stage at harvest. In order to develop a non-destructive index for monitoring the progression of ripening, the difference in absorbance between two wavelengths near the chlorophyll- a absorption peak (670 and 720 nm; index of absorbance difference, I AD ) was related to the time course of ethylene production during on-tree ripening of peaches (cv. ‘Fayette’) and nectarines (cvs. ‘Laura’ and ‘Stark Red Gold’). For each variety, consecutive stages of ripening, as defined according to ethylene production (pre-climacteric, climacteric, post-climacteric), occurred in the same ranges of I AD in different years (2003 and 2004). In 2005, the relationship I AD /ethylene production was used to classify fruit at harvest according to their ripening stage (class 0: pre-climacteric; class 1: onset of climacteric; class 2: climacteric). For each cultivar, the transition from class 1 to 2 was marked by increased ethylene production, and reduced flesh firmness (FF) and titratable acidity (TA). In contrast, fruit quality traits did not discriminate between fruit belonging to classes 0 and 1. In ‘Stark Red Gold’ nectarines, the robustness of the I AD was further corroborated by changes in transcript levels of genes which are either up- or down-regulated during peach fruit ripening. Class 0 fruit had the lowest transcript amount of the up-regulated genes and the highest of the down-regulated ones, while the opposite occurred in class 2 fruit. Moreover, mRNA abundance of some marker genes discriminated class 0 and 1 fruit. Peaches and nectarines graded at harvest according to the I AD also differed in their postharvest ripening behaviour: fruit with higher I AD produced lower amounts of ethylene, began to soften later, and maintained higher TA than those with lower I AD . Present data demonstrate that the I AD identifies physiological changes occurring during ripening regardless of the fact that they might have or not led to appreciable modifications in fruit quality. Therefore, the I AD can be regarded as a very promising tool both for practical and scientific applications, since it allows to monitor on-tree fruit ripening, to establish accurately the optimal harvest time, and to reduce the variability which is present in fruit batches.
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- 2008
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27. Puberty in modernizing Kazakhstan: A comparison of rural and urban children
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Igor Tsoy, Livia Galletti, Orazak Ismagulov, Maria Giovanna Belcastro, Turegeldy Sharmanov, Ainagul Ismagulova, Fiorenzo Facchini, Giorgio Bedogni, Matteo Goldoni, Sara Rizzoli, Giovanni Fiori, Facchini F., Fiori G., Bedogni G., Galletti L., Ismagulov O., Ismagulova A., Sharmanov T., Tsoy I., Belcastro M.G., Rizzoli S., and Goldoni M.
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Male ,Rural Population ,Aging ,Time Factors ,Adolescent ,Urban Population ,Physiology ,Epidemiology ,Health Status ,Living environment ,Ethnic group ,Pilot Projects ,Kazakh ,URBAN ,Russia ,MENARCHE ,Genetics ,medicine ,Humans ,Nutrition survey ,Sex organ ,Social Change ,Child ,Sex Characteristics ,Anthropometry ,business.industry ,KAZAKHSTAN ,Age Factors ,Public Health, Environmental and Occupational Health ,RURAL ,Erikson's stages of psychosocial development ,language.human_language ,Pubic hair ,medicine.anatomical_structure ,PUBERTY ,Menarche ,language ,Female ,business ,Demography - Abstract
Data on puberty development are available for several countries but not for Central Asia.Using data collected during the Kazakhstan Health and Nutrition Survey (KHA-ES), we evaluated the relationship between the living environment (rural vs. urban), ethnicity (Russians vs. Kazakhs) and pubertal status in children living in Kazakhstan.Genital (G1-G5), breast (B1-B5) and pubic hair (PH1-PH5) development were evaluated in a sample of 2389 boys and 2416 girls using Tanner's criteria. Age at menarche was evaluated using the 'status quo' and 'recall' methods.Rural children were older than urban children at stagesor =G2 for males andor =B2 for females, and this difference was more evident for Russian males. Differences levelled out at later stages of development in Kazakh males and in the pooled girls. The living environment was slightly but significantly associated with median age at menarche (12.89 years for urban Kazakhs to 13.43 years for rural Kazakhs). Male and female Kazakhs were older than Russians at stages 4 and 5, especially in the urban area.A relationship between pubertal status and the living environment was present in a rapidly modernizing country such as Kazakhstan.
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- 2008
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28. Anti-IL17 and anti-IL23 biologic drugs for genital psoriasis: a single-center retrospective comparative study
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Andrea Cortese, Luigi Gargiulo, Luciano Ibba, Giovanni Fiorillo, Francesco Toso, Carlo Alberto Vignoli, Alessandra Narcisi, Antonio Costanzo, and Mario Valenti
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biologics ,genital psoriasis ,psoriasis treatment ,Dermatology ,RL1-803 - Abstract
Genital psoriasis affects 33-63% patients with psoriasis during the course of disease, usually leading to a severe reduction of patient’s quality of life. This study aims to retrospectively asses the effectiveness of interleukin (IL)-23 and IL-17 inhibitors in a real-life population affected by moderate-to-severe plaque psoriasis with genital involvement coming from our dermatology department. A total of 86 patients with diagnosis of moderate-to-severe plaque psoriasis with severe genital involvement were enrolled. Patient characteristics, Psoriasis Area and Severity Index (PASI), and Static Physician Global Assessment of Genitalia (sPGA-G) at each visit were recorded. During the treatment, the mean PASI decreased from 12,8 at 0,63 at week 52; PGA of 0/1 was reached by 97,40% at week 52 and by 100% of patients (37/37) at week 104. No significant differences between the IL-23 and IL-17 inhibitors were observed; indeed the bio-naive group of patients demonstrated superior response compared to the group of patient bio-experienced. Our findings confirmed that IL-23 and IL-17 inhibitors as a safe and effective therapeutic option for the treatment of genital psoriasis.
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- 2023
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29. Sorafenib-Induced Acute Generalized Exanthematous Pustulosis
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Andrea Cortese, Saverio Pancetti, Tiziana Pressiani, Francesco Toso, Giovanni Fiorillo, Costanzo Antonio, and Riccardo G. Borroni
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sorafenib ,acute generalized exanthematous pustulosis ,severe cutaneous adverse reaction ,tyrosin-kinase inhibitors ,Dermatology ,RL1-803 - Published
- 2023
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30. Frontal Fibrosing Alopecia Associated with Oral Erosive Lichen Planus: Two Locations, One Disease
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Francesco Toso, Andrea Cortese, Giovanni Fiorillo, Antonio Costanzo, and Riccardo Borroni
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alopecia ,lichen ,dermopathology ,dermoscopy ,Dermatology ,RL1-803 - Published
- 2023
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31. INNOVATIVE APPLICATION OF NON-DESTRUCTIVE TECHNIQUES FOR FRUIT QUALITY AND DISEASE DIAGNOSIS
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Francesco Spinelli, Massimo Noferini, Guglielmo Costa, Giovanni Fiori, R.A. MARTIN, ISHS, ACTA HORTICULTURAE, G. Costa, M. Noferini, G. Fiori, and F. Spinelli
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OLFACTORY FINGERPRINT ,business.industry ,media_common.quotation_subject ,food and beverages ,Disease ,Horticulture ,ACTINIDIA ,E-NOSE ,NIRS ,Risk analysis (engineering) ,Non destructive ,Medicine ,Quality (business) ,business ,KIWIFRUIT ,media_common - Abstract
To date non-destructive techniques, such as Near Infra Red Spectroscopy (NIRS) and the electronic nose, are used only to segregate fruit based on pre-selected quality attributes. Since these techniques allow rapid and easy determination of a wide range of internal attributes related to fruit quality, the collected data could be used in the field to establish proper harvesting time or, in packing houses, to optimise storage strategy. In addition, analysis of volatile compounds performed via e-nose allows early diagnosis of important fruit diseases such as “grey mould” and Sclerotinia rot. This report presents preliminary results on the use of NIRS and e-nose techniques for fruit quality determination and as an alternative approach for early diagnosis on asymptomatic fruits. The research was carried on Actinidia deliciosa (‘Hayward’ and Summerkiwi™) and Actinidia chinensis (‘Hort16A’). Fruit quality studies were performed on all cultivars in the field as well as in the packing house. The diagnostic studies were performed under controlled conditions on fruit experimentally inoculated with pathogenic fungi. The olfactory profiles of control and inoculated fruits were compared by means of PCA.
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- 2007
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32. [Considerations on what we can (and what we should not) ask to registries]
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Antonio, Addis, Elena, Berti, Rossana, De Palma, Giovanni, Fiori, Donato, Papini, and Giuseppe, Traversa
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Research Design ,Humans ,Public Health ,Registries - Abstract
This article presents a summary of the discussion which took place during the works of PRIER II in the session dedicated to the methodology of registries. Following a thorough analysis of the possible methods and the limits which deal with the collection of clinical data through the registries, the different points of view were compared, perhaps the most relevant, related to this activity. All this has been done by taking advantage by the possibility to observe aspects from different points of view. In particular, the exercise considered those who have to deal with the methodological aspects of the registries as an operator of public health or as a private operator who creates services for companies. The final goal, again, was to line up a few essential points accompanied by reasoning and comments useful to anyone who wants to address the issue of registries from the methodological point of view.
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- 2015
33. Corporate Social Responsibility and Stock Prices: A Study on the Italian Market
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Giovanni Fiori, Francesca di Donato, and Maria Federica Izzo
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Corporate social performance ,Finance ,Corporate Social Performance ,Employees ,business.industry ,Corporate governance ,Stakeholder ,Corporate Real Estate ,Community ,Stock prices ,General Business, Management and Accounting ,Corporate Social Responsibility ,Corporate social responsibility ,ENvironment ,Business ,Stock (geology) ,Corporate security - Abstract
This study investigates the impact of Corporate Social Performance on stock prices of Italian listed companies. The main stream of literature focuses on the relation between CSR and financial performance, showing contradictory results that still feed a debate, which has not yet reached a unanimous and widely shared position. Concerning the selection of the measure of performance, we chose stock prices as a proxy for financial performance, in order to measure the perception and reaction of financial markets to the companies’ socially responsible behaviors. Using different social performance indicators concerning environment, community and employment activities, we found evidence that a good social performance has a negative influence on stock prices in the Italian Stock Exchange Market. This phenomenon is particularly evident if the environmental strategies of the Italian listed companies are considered. Hence, the Italian investors perceive these practices as avoidable expenses reducing shareholders’ income and companies’ value and recognize a negative market premium, in terms of lower stock prices, to socially responsible enterprises. This evidence is consistent with the peculiarities of the Italian capitalism structure, which, because of its backwardness in CSR topics and related issues, seems to be not yet mature enough to evaluate appropriately the value of these policies
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- 2015
34. Adherence to AIOM (Italian Association of Medical Oncology) lung cancer guidelines in Italian clinical practice: Results from the RIGHT-3 (research for the identification of the most effective and highly accepted clinical guidelines for cancer treatment) study
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Sandro, Barni, Evaristo, Maiello, Massimo, Di Maio, Andrea, Ardizzoni, Federico, Cappuzzo, Ernesto, Maranzano, Silvia, Novello, Chiara, Bennati, Alessandra, Ori, Sara, Rizzoli, Lucio, Crinò, Giovanni, Fiori, Barni, Sandro, Maiello, Evaristo, Di Maio, Massimo, Ardizzoni, Andrea, Cappuzzo, Federico, Maranzano, Ernesto, Novello, Silvia, Bennati, Chiara, Ori, Alessandra, Rizzoli, Sara, and Crinò, Lucio
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Oncology ,Male ,Cancer Research ,Lung Neoplasms ,Organoplatinum Compounds ,medicine.medical_treatment ,Pilot Projects ,Guideline ,Medical Oncology ,Diagnosis ,Guidelines ,Lung cancer ,Treatment ,Pulmonary and Respiratory Medicine ,Antineoplastic Agent ,Retrospective Studie ,Carcinoma, Non-Small-Cell Lung ,Stage (cooking) ,Middle Aged ,Italy ,Cardiothoracic surgery ,Chemotherapy, Adjuvant ,Female ,Guideline Adherence ,Diagnosi ,Human ,medicine.medical_specialty ,Concordance ,Antineoplastic Agents ,Internal medicine ,medicine ,Humans ,Pilot Project ,Retrospective Studies ,Aged ,Neoplasm Staging ,business.industry ,Research ,Organoplatinum Compound ,Cancer ,Retrospective cohort study ,medicine.disease ,Radiation therapy ,Lung Neoplasm ,Concomitant ,Positron-Emission Tomography ,business - Abstract
Objectives Clinical practice guidelines represent a key tool to improve quality and reduce variability of cancer care. In 2004, Italian Association of Medical Oncology (AIOM) launched the RIGHT (research for the identification of the most effective and highly accepted clinical guidelines for cancer treatment) program. The third step, RIGHT-3, evaluated the concordance between AIOM lung cancer guidelines and Italian clinical practice. Materials and methods RIGHT-3 was a retrospective observational study, conducted in 53 Italian centers treating lung cancer. Sampling from AIOM database of 230 centers was stratified by presence of thoracic surgery and geographic distribution. To describe the adherence to AIOM guidelines (2009 edition), 11 indicators regarding diagnostic and treatment procedures were identified. Patients with non-small-cell lung cancer (NSCLC) diagnosis who had first visit in 2010 were divided into 3 groups, based on TNM stage: I-II-IIIA (5 indicators), IIIB (3 indicators) and IV (3 indicators). Results 708 patients were enrolled; 680 were eligible: 225 patients in stage I-II-IIIA; 156 patients in stage IIIB; 299 patients in stage IV. Cyto-histological diagnosis was available in 96%, 97%, 96% of stage I-II-IIIA, IIIB, IV respectively. Positron-emission tomography was performed in 64% of stage I-II-IIIA and 46% of stage IIIB. 88% of stage I-II patients eligible for surgery underwent lobectomy; after surgery, 61% of stage II and 57% of stage IIIA patients received adjuvant chemotherapy. Among stage IIIB patients who received combined chemo- radiotherapy, sequential approach was more common than concomitant treatment (86% vs. 14%). Among stage IV patients, 87% received platinum-based first-line treatment, and 70% received second-line. Conclusion The RIGHT-3 study showed that, in 2010, adherence to Italian NSCLC guidelines was high for many indicators (including those related to treatment of stage IV patients), but lower for some diagnostic procedures. Guidelines adherence monitoring can be useful to reduce variability in cancer care.
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- 2015
35. USING NIRS TO DETERMINE INTRINSIC FRUIT QUALITY AND HARVEST DATE
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Giovanni Fiori, Guglielmo Costa, and Massimo Noferini
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chemistry.chemical_compound ,Horticulture ,chemistry ,Chlorophyll ,media_common.quotation_subject ,Environmental science ,Quality (business) ,media_common - Published
- 2006
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36. INTERNAL FRUIT QUALITY: HOW TO INFLUENCE IT, HOW TO DEFINE IT
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Guglielmo Costa, Giovanni Fiori, Massimo Noferini, and Vanina Ziosi
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business.industry ,Harvest time ,media_common.quotation_subject ,Flesh ,Flavour ,food and beverages ,Cultural management ,Ripening ,Agricultural engineering ,Horticulture ,Internal quality ,Geography ,Soluble solids ,Quality (business) ,Telecommunications ,business ,media_common - Abstract
Fruit quality is influenced by cultural management in field, by the fruit picking time and by the storage strategy. The choice of the best techniques and strategies to enhance fruit quality is difficult, and even more complicate is the definition of the internal fruit quality changes occurring in pre- and post-harvest conditions. In fact, internal fruit quality is strictly related to the changes occurring during the ripening and maturation syndrome. Define them with accuracy would allow to verify the techniques adopted validity, to monitor the evolution of the ripening in field and in storage and finally to offer a uniform fruit quality to the consumers. Fruit internal quality is represented by the fruit texture, the sugars and organic acids content, the flavour, etc. Although a precise definition of the quality would require equipped laboratory and knowledgeable personnel, the standard techniques for assessing fruit quality are quite simple (refractometer and penetrometer for flesh soluble solids content and flesh firmness; titration for acidity, etc). These determinations are carried out on samples of a limited number of fruit, often not representative of all the fruit, but give the possibility to have real-time information. However, recently, the availability of non-destructive techniques to assess fruit quality, also offer real-time information, allow to determine quality traits on a high number or even on all the fruit, to repeat the analyses on the same samples monitoring their physiological evolution, to determine with the same measurement a number of information on several fruit quality parameters. Here are reported examples on how the internal fruit quality can be influenced (harvest time, 1-MCP applications, storage strategy) and the possibility offered by NIRs (near infrared spectroscopy) and electronic-nose non-destructive devices to monitor and define fruit quality changes of some fruit specie in pre- and post-harvest situations.
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- 2006
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37. DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases
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Matthias Wielscher, Pooja R. Mandaviya, Brigitte Kuehnel, Roby Joehanes, Rima Mustafa, Oliver Robinson, Yan Zhang, Barbara Bodinier, Esther Walton, Pashupati P. Mishra, Pascal Schlosser, Rory Wilson, Pei-Chien Tsai, Saranya Palaniswamy, Riccardo E. Marioni, Giovanni Fiorito, Giovanni Cugliari, Ville Karhunen, Mohsen Ghanbari, Bruce M. Psaty, Marie Loh, Joshua C. Bis, Benjamin Lehne, Nona Sotoodehnia, Ian J. Deary, Marc Chadeau-Hyam, Jennifer A. Brody, Alexia Cardona, Elizabeth Selvin, Alicia K. Smith, Andrew H. Miller, Mylin A. Torres, Eirini Marouli, Xin Gào, Joyce B. J. van Meurs, Johanna Graf-Schindler, Wolfgang Rathmann, Wolfgang Koenig, Annette Peters, Wolfgang Weninger, Matthias Farlik, Tao Zhang, Wei Chen, Yujing Xia, Alexander Teumer, Matthias Nauck, Hans J. Grabe, Macus Doerr, Terho Lehtimäki, Weihua Guan, Lili Milani, Toshiko Tanaka, Krista Fisher, Lindsay L. Waite, Silva Kasela, Paolo Vineis, Niek Verweij, Pim van der Harst, Licia Iacoviello, Carlotta Sacerdote, Salvatore Panico, Vittorio Krogh, Rosario Tumino, Evangelia Tzala, Giuseppe Matullo, Mikko A. Hurme, Olli T. Raitakari, Elena Colicino, Andrea A. Baccarelli, Mika Kähönen, Karl-Heinz Herzig, Shengxu Li, BIOS consortium, Karen N. Conneely, Jaspal S. Kooner, Anna Köttgen, Bastiaan T. Heijmans, Panos Deloukas, Caroline Relton, Ken K. Ong, Jordana T. Bell, Eric Boerwinkle, Paul Elliott, Hermann Brenner, Marian Beekman, Daniel Levy, Melanie Waldenberger, John C. Chambers, Abbas Dehghan, and Marjo-Riitta Järvelin
- Subjects
Science - Abstract
Chronic inflammation, marked by C-reactive protein, has been associated with changes in methylation, but the causal relationship is unclear. Here, the authors perform a Epigenome-wide association meta-analysis for C-reactive protein levels and find that these methylation changes are likely the consequence of inflammation and could contribute to disease.
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- 2022
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38. Italian validation of MOAS and NOSIE: a useful package for psychiatric assessment and monitoring of aggressive behaviours
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Giovanni Fiori, Lucia Simoni, Francesco Margari, Massimo Casacchia, Rosanna Matarazzo, Rita Roncone, Simona Safran, and Massimiliano Dieci
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Adult ,Male ,medicine.medical_specialty ,Time Factors ,Adolescent ,Psychometrics ,Validity ,Poison control ,Test validity ,Risk Assessment ,Age Distribution ,Sex Factors ,Rating scale ,Brief Psychiatric Rating Scale ,Humans ,Medicine ,Psychiatry ,Modified Overt Aggression Scale ,Psychiatric Status Rating Scales ,Inpatients ,business.industry ,Mental Disorders ,Reproducibility of Results ,Original Articles ,Middle Aged ,Aggression ,Psychiatry and Mental health ,Italy ,Convergent validity ,Female ,business ,Social Adjustment ,Clinical psychology - Abstract
A validation of two rating scales is presented. We first translated the Modified Overt Aggression Scale (MOAS) and the Nurses' Observation Scale for In‐patient Evaluation (NOSIE), which cover different aspects of psychopathology, into Italian. We then tested their validity and reliability in terms of inter‐rater and internal consistency. For validity, both cases and controls were included: for the MOAS we compared patients who were aggressive (cases) to those who were presumably non‐aggressive (controls). For the NOSIE, cases were acute inpatients and controls were subjects with expected stable behaviour. The Brief Psychiatric Rating Scale (BPRS) was also administered to cases in order to test convergent validity. Either the NOSIE and/or MOAS scales were administered to 358 psychiatric inpatients. A subset of these patients (131 for the MOAS and 226 for the NOSIE) was also used to test the inter‐rater reliability. Both scales showed good psychometric properties. The correlation coefficients between raters were much higher than 0.75 (for the NOSIE) or 0.90 (for the MOAS), while the discriminant power between cases and controls was confirmed for both scales and good concordance with BPRS was observed. The NOSIE showed good internal consistency for all domains except neatness. In general the MOAS showed better results than the NOSIE for all psychometric properties, although both scales are suitable for monitoring the behaviour and aggression of acute ward inpatients. Copyright © 2005 Whurr Publishers Ltd.
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- 2005
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39. Resistance Training Using Flywheel Device Improves the Shot Precision in Senior Elite Tennis Players: A Randomized Controlled Study
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Marco Centorbi, Giovanni Fiorilli, Giulia Di Martino, Andrea Buonsenso, Gabriele Medri, Carlo della Valle, Nicolina Vendemiati, Enzo Iuliano, Giuseppe Calcagno, and Alessandra di Cagno
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strength training ,eccentric overload ,tennis skill ,tennis stroke ,athletic performance ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
The aim of the study was to assess the effects of 8 weeks of resistance training using a flywheel device applied to upper limbs, compared to traditional isotonic training, on strength and shot precision in tennis. Twenty-seven elite senior tennis players (age: 55.78 ± 2.69) were randomly divided into an experimental group (EG) using flywheel devices (n = 13) and a control group (CG) performing isotonic training (n = 14). The EG program included forehand, backhand, and one-handed shoulder press movements, while the CG performed seven resistance exercises on isotonic machines. A similar workout intensity was ensured using the Borg’s CR-10 scale. The assessment included a 30s arm curl test, a medicine ball throw test, and forehand/backhand/overhead shot precision tests. A significant time effect was found in the 30s arm curl test for the EG (F(1,25) = 13.09; p = 0.001), along with a time * group interaction (F(1,25) = 5.21; p = 0.031). A significant group difference was observed in the forehand shot precision test, where the EG achieved better scores than the CG and significant interaction time * group (F(1,25) = 8.35; p = 0.008). In the shot backhand precision test, a significant effect of time (F(1,25) = 5.01; p = 0.034) and significant time * group interaction were found (F(1,25) = 4.50; p = 0.044), but there was no significant difference between groups. Resistance training with flywheel devices has shown potential in improving tennis performance. Applying overload to specific athletic movements during both concentric and eccentric phases in the EG has shown enhanced strength and neuromuscular coordination in relation to shot precision, thereby enabling simultaneous improvements in both conditioning and the technical aspects of fundamental tennis shots.
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- 2023
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40. Acute Effects of Combining Whole-Body Electromyostimulation with Resistance Training in Active Women
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Andrea Buonsenso, Marco Centorbi, Giulia Di Martino, Carlo Della Valle, Gloria Di Claudio, Domenico Di Fonza, Erika Di Zazzo, Giuseppe Calcagno, Alessandra di Cagno, and Giovanni Fiorilli
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whole body electromyostimulation ,isometric strength ,active woman ,CK levels ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Strength training elicits benefits both in performance and on a psychological level in women, such as increased muscle strength and improved self-esteem. Whole-body electromyostimulation (WB-EMS) could be a training strategy for enhancing muscular strength. The aim of this study was to assess the acute effects of a single session of WB-EMS superimposed over classic resistance training on isometric strength, endurance strength and flexibility. Furthermore, the safety of the protocol was assessed by monitoring the levels of creatine kinase (CK) 48 h after the training protocol was completed. Sixteen active women (aged 22.06 ± 1.88) were randomly assigned to an experimental group (EG) (n = 8) and a control group (CG) (n = 8). The EG performed four sets of 12 repetitions of three strength exercises with superimposed WB-EMS, while the CG performed the same protocol without WB-EMS. RM-ANOVA showed a significant time*group interaction on posterior kinetic chain extensors’ mean and peak strength in the EG (F(1,14) = 10.036; p = 0.007; and F(1,14) = 20.719; p < 0.001; respectively). A significant time*group interaction was found in the sit and reach test for the EG (F(1,14) = 10.362; p = 0.006). Finally, ANOVA performed on the CK levels showed no significant difference between the groups (F(1,14) = 0.715; p = 0.412). WB-EMS training led to an immediate improvement in strength performance and flexibility, and this protocol was shown to be safe in terms of CK levels, 48 h after completing the training protocol.
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- 2023
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41. NON-DESTRUCTIVE TECHNIQUE TO ASSESS INTERNAL FRUIT QUALITY
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A. Orlandi, Massimo Noferini, Giovanni Fiori, O. Miserocchi, and Guglielmo Costa
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Non destructive ,media_common.quotation_subject ,Quality (business) ,Agricultural engineering ,Horticulture ,Mathematics ,media_common - Published
- 2003
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42. USE OF LIGHT REFLECTIVE MULCH TO AFFECT YIELD AND FRUIT QUALITY
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Luca Corelli Grappadelli, Guglielmo Costa, Massimo Noferini, and Giovanni Fiori
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Horticulture ,Agronomy ,Fruit weight ,Yield (wine) ,Shoot ,Light reflection ,food and beverages ,Biology ,Mulch ,Vineyard ,Morning ,Transpiration - Abstract
A reflecting mulch patented in New Zealand (Extenday®) was tested on a ‘Hayward’ kiwifruit vineyard to enhance light reflection and to study the effect of the mulch on gas exchange, yield and fruit quality. The mulch was positioned in one section of 3 alley-rows, so that it surrounded 2 rows on both sides and the results were compared with those obtained on uncovered row sections serving as the control. The mulch was laid down at shoot emergence and left up to a month after harvest. Data on vegetative and fruiting performance were collected throughout the vegetative season and at harvest. Whole-vine gas-exchanges were continuously monitored for two weeks during the summer using an original device. At harvest fruits were weighed, the average fruit weight determined and the main quality traits were assessed for the control- and the mulched-vine fruits. The reflecting mulch promoted higher photosynthesis during the day; with transpiration being higher in the morning and lower in the afternoon in the mulched vines as compared to the control. Yield and average fruit weight were positively affected by the mulch.
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- 2003
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43. NIRS EVALUATION OF PEACH AND NECTARINE FRUIT QUALITY IN PRE- AND POST-HARVEST CONDITIONS
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Anna Maria Bregoli, Guglielmo Costa, Massimo Noferini, O. Miserocchi, and Giovanni Fiori
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Horticulture ,media_common.quotation_subject ,Environmental science ,Quality (business) ,Pre and post ,media_common - Published
- 2002
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44. Whole body-electromyostimulation effects on serum biomarkers, physical performances and fatigue in Parkinson’s patients: A randomized controlled trial
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Alessandra di Cagno, Andrea Buonsenso, Marco Centorbi, Luigi Manni, Alfonso Di Costanzo, Giusy Casazza, Attilio Parisi, Germano Guerra, Giuseppe Calcagno, Enzo Iuliano, Marzia Soligo, Giovanni Fiorilli, for The WB-EMS Parkinson’s Group, Francesco Lena, Nicola Modugno, and Federico Quinzi
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Parkinson’s disease ,neurotrophic factors ,physical activity ,functional capacity ,muscle stimulation ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
BackgroundWhole-body electromyostimulation (WB-EMS) was never previously applied to Parkinson’s disease (PD) patients. This randomized controlled study aimed to find the most effective and safe WB-EMS training protocol for this population.MethodsTwenty-four subjects (age: 72.13 ± 6.20 years), were randomly assigned to three groups: a high-frequency WB-EMS strength training group (HFG) (rectangular stimulation at 85 Hz, 350 μs, 4 s stimulation/4 s rest), a low-frequency WB-EMS aerobic training group (LFG) (rectangular stimulation 7 Hz, 350 μs, with a continuous pulse duration), and an inactive control group (CG). Participants of the two experimental groups underwent 24 controlled WB-EMS training sessions, with a duration of 20 min each, during 12-week intervention. Serum growth factors (BDNF, FGF-21, NGF and proNGF), α-synuclein, physical performance and Parkinson’s Disease Fatigue Scale (PFS-16) responses were analyzed to evaluate the pre-post variation and differences among groups.ResultsSignificant interactions of Time*Groups were detected for BDNF (Time*Groups p = 0.024; Time*CG, b = −628, IC95% = −1,082/−174, p = 0.008), FGF-21 (Time*Groups p = 0.009; Time*LFG b = 1,346, IC95% = 423/2268, p = 0.005), and α-synuclein (Time*Groups p = 0.019; Time*LFG b = −1,572, IC95% = −2,952/−192, p = 0.026). Post hoc analyses and comparisons of ΔS (post–pre), performed independently for each group, showed that LFG increased serum BDNF levels (+ 203 pg/ml) and decreased α-synuclein levels (−1,703 pg/ml), while HFG showed the opposite effects (BDNF: −500 pg/ml; α-synuclein: + 1,413 pg/ml). CG showed a significant BDNF reduction over time. Both LFG and HFG showed significant improvements in several physical performance outcomes and the LFG showed better results than HFG. Concerning PFS-16, significant differences over time (b = −0.4, IC95% = −0.8/−0.0, p = 0.046) and among groups (among all groups p < 0.001) were found, and the LFG exhibited better results than the HFG (b = −1.0, IC95% = −1.3/−0.7, p < 0.001), and CG (b = −1.7, IC95% = −2.0/−1.4, p < 0.001) with this last one that worsened over time.ConclusionLFG training was the best choice for improving or maintaining physical performance, fatigue perception and variation in serum biomarkers.Clinical trial registrationhttps://www.clinicaltrials.gov/ct2/show/NCT04878679, identifier NCT04878679.
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- 2023
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45. IFRS and International Differences: An Empirical Analysis on their Application Worldwide
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Francesca di Donato, Giovanni Fiori, and Daniele Macciocchi
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business.industry ,Accounting ,Business ,General Business, Management and Accounting - Abstract
This study is based on the analysis of Nobes (2006) and Zeff (2007), demonstrating that different countries tend to adopt IFRS through the implementation of the options that are closely related to their culture. In a sample of 189 publicly traded firms from 7 different countries, we provide a first evidence of the application of some specific IAS/IFRS standards worldwide. IFRS, like any other set of accounting standards, offer firms substantial discretion (different options) in applying the standards. Our descriptive statistics show that, on average, countries tend to implement the options more suitable for their accounting, legal and tax culture, making international differences within IFRS survive. This study wants to be a call for future research regarding the IAS/IFRS adoption worldwide.
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- 2014
46. What drives value relevance? The visibility effect in the adoption of a new accounting standard
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Giovanni Fiori, Riccardo Tiscini, and Marco Fasan
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Other comprehensive income ,Organizational Behavior and Human Resource Management ,IAS 1 ,Transparency (market) ,business.industry ,Value relevance ,OCI ,Accounting ,Visibility effect ,IAS 1 revised ,Financial information ,Business ,Finance - Abstract
This article contributes to the literature on the reasons that drive changes in financial information value relevance after the issuance and implementation of a new accounting standard. Currently, value relevance changes are explained through the lens of the reporting location literature, which points to the increased transparency of the reports as the main driver of value relevance increases. We empirically analyse the changes in the value relevance of other comprehensive income (OCI) after the issuance of IAS 1 Revised in continental Europe, and we discuss the role of visibility of accounting standards (the visibility effect) in explaining value relevance changes. We also test whether firm size and the regulatory quality of the country in which a company is listed drive the results. This study may be of interest to investors and standard setters, given the role that they play in increasing the environment of information. One of the implications of the visibility effect hypothesis is for standard setters to pay more attention to the way standards are communicated and made public to market participants.
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- 2014
47. The Modernizing Kazakhstan: A Review of Biomedical Data
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Giovanni Fiori and Fiorenzo Facchini
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education.field_of_study ,medicine.medical_specialty ,Health Status ,Incidence (epidemiology) ,Population Dynamics ,Urbanization ,Population ,General Social Sciences ,Modernization theory ,medicine.disease ,Obesity ,Kazakhstan ,Environmental protection ,Human biology ,Epidemiology ,medicine ,Humans ,Underweight ,medicine.symptom ,education ,Socioeconomics ,Anthropology, Cultural - Abstract
In order to focus the situation of Kazakhstan today in relation to the processes of modernization and transition to a market economy and to evidence their effects on the biology and health status of the population of Kazakhstan, we have reviewed recently available data for this region (1993-1999). Kazakhstan is still characterized by a pyramid shaped age distribution of its population and by a high incidence of not communicable diseases and lack of nutrient and micronutrients, especially among children. However, the population of Kazakhstan seems to be not immune to the diseases of the modernization. I.e., among women obesity is more frequent than underweight, especially in the urban areas. In rural populations the frequency of clinically relevant hypertension resulted low in the more isolated and traditionally living communities but it increased to 20% in the less isolated one. Although it is expected a strong increase of urbanized population in the next 25 years, currently, modernization is probably influencing life style and nutritional habits of almost only a minority of the inhabitants of Kazakhstan.
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- 2001
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48. Lung volume, chest size, and hematological variation in low-, medium-, and high-altitude Central Asian populations
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Eduardo Tarazona-Santos, Giovanni Fiori, Ainagul Ismagulova, Orazak Ismagulov, Fiorenzo Facchini, and Davide Pettener
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Adult ,Thorax ,medicine.medical_specialty ,Vital capacity ,Hematocrit ,Body Mass Index ,Perimeter ,FEV1/FVC ratio ,Animal science ,Forced Expiratory Volume ,medicine ,Humans ,Lung volumes ,Lung ,Hematologic Tests ,medicine.diagnostic_test ,business.industry ,Altitude ,Effects of high altitude on humans ,Adaptation, Physiological ,Body Height ,Surgery ,Anthropology ,Asia, Central ,Anatomy ,Diaphragmatic excursion ,Lung Volume Measurements ,business - Abstract
To evaluate adaptive responses to high-altitude environment, we examined three groups of healthy adult males from Central Asia: 94 high-altitude (HA) Kirghiz subjects (3,200 m above sea level); 114 middle-altitude (MA) Kazakh subjects (2,100 m), and 90 low-altitude (LA) Kirghiz subjects (900 m). Data on chest size (chest perimeter and chest diameter), lung volume (forced expiratory volume (FEV) and forced expiratory volume in 1 sec (FEV1)), and hematological parameters (hemoglobin, erythrocytes, hematocrit, and SaO(2)) are discussed. The results show that 1) chest shape is less flat in the samples living at higher altitude. In the HA sample, chest perimeter is lower but chest excursion is high. 2) In the highlanders, forced vital capacity (FVC) and FEV1 are no higher than in the other samples, even when corrected for stature and body weight. The negative correlation between FVC-FEV1 and age decreases with increasing altitude. 3) The HA and MA samples have higher values of hemoglobin, erythrocytes, and hematocrit. The HA sample has lower SaO(2) and higher arterial oxygen content than the LA sample. No association between hematocrit and age was detected in the four samples. The results indicate that the high-altitude Kirghiz present features of developmental acclimatization to hypobaric hypoxia which are also strongly influenced by other major high-altitude environmental stresses.
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- 2000
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49. Trading Genes along the Silk Road: mtDNA Sequences and the Origin of Central Asian Populations
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Rosa Martínez-Arias, Jaume Bertranpetit, Elena Bosch, Jordi Clarimón, Eva Mateu, Giovanni Fiori, Francesc Calafell, Fiorenzo Facchini, Donata Luiselli, Anna Pérez-Lezaun, Davide Pettener, and David Comas
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Mitochondrial DNA ,Asia ,Databases, Factual ,Genetic Linkage ,Molecular Sequence Data ,Population ,Population genetics ,Biology ,DNA, Mitochondrial ,Analysis of molecular variance ,Nucleotide diversity ,03 medical and health sciences ,Asian People ,Gene Frequency ,Sequence Homology, Nucleic Acid ,Genetic variation ,Genetics ,Humans ,Genetics(clinical) ,East Asia ,education ,Phylogeny ,Genetics (clinical) ,030304 developmental biology ,Uighur ,Kazakh ,0303 health sciences ,education.field_of_study ,Polymorphism, Genetic ,Base Sequence ,Models, Genetic ,mtDNA ,Altitude ,030305 genetics & heredity ,Genetic Variation ,Gene Pool ,Sequence Analysis, DNA ,Locus Control Region ,Europe ,Atmospheric Pressure ,Kirghiz ,Evolutionary biology ,Africa ,Asia, Central ,Gene pool ,Central Asians ,Research Article - Abstract
SummaryCentral Asia is a vast region at the crossroads of different habitats, cultures, and trade routes. Little is known about the genetics and the history of the population of this region. We present the analysis of mtDNA control-region sequences in samples of the Kazakh, the Uighurs, the lowland Kirghiz, and the highland Kirghiz, which we have used to address both the population history of the region and the possible selective pressures that high altitude has on mtDNA genes. Central Asian mtDNA sequences present features intermediate between European and eastern Asian sequences, in several parameters—such as the frequencies of certain nucleotides, the levels of nucleotide diversity, mean pairwise differences, and genetic distances. Several hypotheses could explain the intermediate position of central Asia between Europe and eastern Asia, but the most plausible would involve extensive levels of admixture between Europeans and eastern Asians in central Asia, possibly enhanced during the Silk Road trade and clearly after the eastern and western Eurasian human groups had diverged. Lowland and highland Kirghiz mtDNA sequences are very similar, and the analysis of molecular variance has revealed that the fraction of mitochondrial genetic variance due to altitude is not significantly different from zero. Thus, it seems unlikely that altitude has exerted a major selective pressure on mitochondrial genes in central Asian populations.
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- 1998
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50. Body composition in Central Asia populations: Fat patterning variation in the Kazakhs of the Tien Shan mountains and the Uighurs of Semericia
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Giovanni Fiori, Fiorenzo Facchini, Orazak Ismagulov, Ainagul Ismagulova, Davide Pettener, Stefania Toselli, Facchini F., Toselli S., Ismagulov O., Fiori G., Ismagulova A., and Pettener D.
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Geography ,Anthropology ,Central asia ,Genetics ,Hum ,Anatomy ,body composition, fat patterning, Kazakhs ,Ecology, Evolution, Behavior and Systematics ,Demography ,Preliminary analysis - Abstract
Eleven anthropometric variables related to fat patterning were analyzed in two populations of Central Asia, the Kazakhs of the Tien Shan mountains (2100 m) and the Uighurs of the Semericia plains. Subjects were healthy unrelated males, 122 Kazakhs and 79 Uighurs, 19-65 years. Comparisons were done with a preliminary analysis of variance and then by covariance analysis, taking into account the influence of age. The Uighurs, independently of age, show higher values than Kazakhs for all of the characteristics related to fat patterning, but principal components analysis suggests a similar somatic structure in the two samples. The presence of lower adiposity in the Kazakhs than in the Uighurs could be related to stress, probably associated with nutrition and lifestyle in a mountain environment. Am. J. Hum. Biol. 10:241-247, 1998. © 1998 Wiley-Liss, Inc.
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- 1998
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