248 results on '"Girijavallabhan V"'
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2. Highly regioselective nitration reactions provide a versatile method of functionalizing benzocycloheptapyridine tricyclic ring systems: application toward preparation of nanomolar inhibitors of farnesyl protein transferase
3. Inhibiting Fornesyl Protein Transferase with Sch-66336: Potentially a Selective, Noncytotoxic Therapy for Human Cancer
4. Trihalobenzocycloheptapyridine analogues of Sch 66336 as potent inhibitors of farnesyl protein transferase
5. Binding affinities and geometries of various metal ligands in peptide deformylase inhibitors
6. Hepatitis C virus NS3-4A serine protease inhibitors: SAR of new P1 derivatives of SCH 503034
7. HCV NS3 protease domain with P1-P3 macrocyclic ketoamide inhibitor
8. ChemInform Abstract: A Practical Conversion of an Azetidinone to Penem: Synthesis of Sch 34343.
9. ChemInform Abstract: Aqueous Diels-Alder Reactions of Electron Deficient 2-Arylfurans: A Highly Stereoselective Route to 2,2,5-Trisubstituted Tetrahydrofurans Towards a Novel Class of Orally Active Azole Antifungals.
10. ChemInform Abstract: Total Synthesis and Absolute Stereochemistry of the Antifungal Dipeptide Sch 37137 (I) and Its 2S,3S-Isomer.
11. ChemInform Abstract: Ring Contraction Reactions of 2-O-Methanesulfonates of α-Hydroxy- γ-lactones in Aqueous Medium to Oxetane-2-carboxylic Acids: A Convenient Synthesis of 3′-O-Methyloxetanocin and a Formal Synthesis of Oxetanocin.
12. ChemInform Abstract: The Synthesis of Novel HIV-Protease Inhibitors via Silica Gel Assisted Addition of Amines to Epoxides.
13. ChemInform Abstract: Synthesis of Novel Azole Antifungals by a Modified Sharpless Asymmetric Dihydroxylation.
14. ChemInform Abstract: Sch 51048, a Novel Broad-Spectrum Orally Active Antifungal Agent: Synthesis and Preliminary Structure-Activity Profile.
15. ChemInform Abstract: An Enantioselective Synthesis of the Antifungal Agent (2R,3R)-2-(2,4- Difluorophenyl)-3-(methylsulfonyl)-1-(1,2,4-triazol-1-yl)-2-butanol ( Sch 42427; SM 9164).
16. ChemInform Abstract: Advances in the Chemistry of Novel Broad-Spectrum Orally Active Azole Antifungals: Recent Studies Leading to the Discovery of SCH 56592
17. ChemInform Abstract: Highly Regioselective Nitration Reactions Provide a Versatile Method of Functionalizing Benzocycloheptapyridine Tricyclic Ring Systems: Application Toward Preparation of Nanomolar Inhibitors of Farnesyl Protein Transferase.
18. ChemInform Abstract: Novel HIV-Protease Inhibitors Containing β-Hydroxyether and -thioether Dipeptide Isostere Surrogates: Modification of the P3 Ligand.
19. Structure of HCV NS3-4A Protease with an Inhibitor Derived from a Boronic Acid
20. Structure of NS3 complexed with a ketoamide inhibitor SCh491762
21. Structure of the HCV NS3/4A Protease Inhibitor CVS4819
22. Discovery of the HCV NS3/4A Protease Inhibitor SCH503034. Key Steps in Structure-Based Optimization
23. Structure of HEPATITIS C VIRAL NS3 protease domain complexed with NS4A peptide and ketoamide SCH476776
24. HCV NS3-4A protease domain complexed with a macrocyclic ketoamide inhibitor, SCH419021
25. HCV NS3 protease domain with NS4a peptide and a ketoamide inhibitor with P1 and P2 cyclopropylalannines
26. HCV NS3 protease domain with NS4a peptide and a ketoamide inhibitor with a P2 norborane
27. SCH 503034, a Mechanism-Based Inhibitor of Hepatitis C Virus NS3 Protease, Suppresses Polyprotein Maturation and Enhances the Antiviral Activity of Alpha Interferon in Replicon Cells
28. Hepatitis C virus NS3-4A serine protease inhibitors: SAR of moiety with improved potency
29. Hepatitis C virus NS3-4A serine protease inhibitors: Use of a P2–P1 cyclopropyl alanine combination for improved potency
30. Antibiotics: Oligosaccharides
31. Farnesyl Protein Transferase Inhibitors Targeting the Catalytic Zinc for Enhanced Binding.
32. Farnesyl protein transferase inhibitors targeting the catalytic zinc for enhanced binding
33. ChemInform Abstract: Synthesis of (5,6‐Dihydro‐11H‐benzo[5,6]cyclohepta [1,2‐b]pyridin‐11‐ylidene)‐1‐piperidine‐N‐cyanoguanidine Derivatives (I) as Inhibitors of Ras Farnesyl Protein Transferase.
34. Synthesis of 5,6-Dihydro-11H-benzo[5,6]-cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidine-N-cyanoguanidine Derivatives as Inhibitors of Ras Farnesyl Protein Transferase
35. Oligosaccharides
36. Synthesis of C-11 Methyl-Substituted Benzocycloheptapyridine Inhibitors of Farnesyl Protein Transferase
37. Hepatitis C virus NS3-4A serine protease inhibitors: Use of a P 2–P 1 cyclopropyl alanine combination for improved potency
38. Hepatitis C virus NS3-4A serine protease inhibitors: SAR of [formula omitted] moiety with improved potency
39. Potent, Selective, and Orally Bioavailable Tricyclic Pyridyl AcetamideN-Oxide Inhibitors of Farnesyl Protein Transferase with Enhanced in Vivo Antitumor Activity
40. Structure−Activity Relationship of 3-Substituted N-(Pyridinylacetyl)-4- (8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)- piperidine Inhibitors of Farnesyl-Protein Transferase: Design and Synthesis of in Vivo Active Antitumor Compounds
41. Structure of poliovirus type 2 Lansing complexed with antiviral agent SCH48973: comparison of the structural and biological properties of the three poliovirus serotypes
42. ChemInform Abstract: Novel Tricyclic Aminoacetyl and Sulfonamide Inhibitors of RAS Farnesyl Protein Transferase.
43. SCH 48973: a potent, broad-spectrum, antienterovirus compound
44. Detection and structural characterization of ras oncoprotein-inhibitors complexes by electrospray mass spectrometry
45. Ras oncoprotein inhibitors: The discovery of potent, ras nucleotide exchange inhibitors and the structural determination of a drug-protein complex
46. Discovery of novel nonpeptide tricyclic inhibitors of ras farnesyl protein transferase
47. Antitumor 8-chlorobenzocycloheptapyridines: a new class of selective, nonpeptidic, nonsulfhydryl inhibitors of ras farnesylation
48. Novel tricyclic aminoacetyl and sulfonamide inhibitors of Ras farnesyl protein transferase
49. ChemInform Abstract: Concise Asymmetric Routes to 2,2,4‐Trisubstituted Tetrahydrofurans via Chiral Titanium Imide Enolates: Key Intermediates Towards Synthesis of Highly Active Azole Antifungals Sch 51048 and Sch 56592.
50. ChemInform Abstract: Total Synthesis of the Antifungal Cyclic Depsipeptides Sch 57697 (Ia) and Aureobasidin A (Ib).
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