824 results on '"Giroux, M."'
Search Results
2. Classic Contaminants in Aquatic Ecosystems: POPs, PFAS, Heavy Metals, and Microplastics
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Giroux, M. S., Siddiqui, Samreen, Brander, Susanne M., Siddiqui, Samreen, editor, and Brander, Susanne M., editor
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- 2024
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3. Effects of Chlorpyrifos on Cholinesterase and Serine Lipase Activities and Lipid Metabolism in Brains of Rainbow Trout (Oncorhynchus mykiss).
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Greer, JB, Magnuson, JT, Hester, K, Giroux, M, Pope, C, Anderson, T, Liu, J, Dang, V, Denslow, ND, and Schlenk, D
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lipidomics ,neurotoxicology ,organophosphate ,pesticide ,Toxicology ,Pharmacology and Pharmaceutical Sciences - Abstract
Chlorpyrifos is an organophosphorus insecticide that elicits acute toxicity through inhibition of acetylcholinesterase (AChE), leading to acetylcholine accumulation and prolonged stimulation of cholinergic receptors throughout the central and peripheral nervous systems. Previous studies have indicated that neurodevelopment may also be impaired through alternative pathways, including reduction of cAMP catalyzed downstream events. The upstream initiating events that underlie non-cholinergic neurological actions of chlorpyrifos and other organophosphorus compounds remain unclear. To investigate the potential role of disruption of fatty acid signaling as a mechanism of toxicity, lipid metabolism and fatty acid profiles were examined to identify alterations that may play a critical role in upstream signaling in the CNS. Juvenile rainbow trout were treated for 7 days with nominal chlorpyrifos concentrations previously reported to diminish olfactory responses (10, 20, and 40 μg/L). While lethality was noted higher doses, measured chlorpyrifos concentrations of 1.38 μg/L (nominal concentration 10 μg/L) significantly reduced the activity of AChE and two serine lipases, monoacylglycerol lipase and fatty acid amide hydrolase in the brain. Reductions in lysophosphatidylethanolamines (16:0; 18:0, 18:1, and 22:6) derived from the phosphatidylethanolamines and free fatty acids (Palmitic acid16:0; Linolenic acid18:3; Eicosadienoic acid 20:2; Arachidonic acid 20:4; and Docosahexaenoic acid 22:6) were also noted, suggesting that chlorpyrifos inhibited the metabolism of selected phospholipid signaling precursors at sublethal concentrations. These results indicate that in addition to AChE inhibition, environmentally relevant chlorpyrifos exposure alters serine lipase activity and lipid metabolites in the trout brain, which may compromise neuronal signaling and impact neurobehavioral responses in aquatic animals.
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- 2019
4. Correction to: Genetic characterization and expression analysis of wheat (Triticum aestivum) line 07OR1074 exhibiting very low polyphenol oxidase (PPO) activity
- Author
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Hystad, S. M., Martin, J. M., Graybosch, R. A., and Giroux, M. J.
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- 2023
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5. Urinary tract infections and multiple sclerosis: Recommendations from the French Multiple Sclerosis Society
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Donzé, C., Papeix, C., Lebrun-Frénay, C., Collongues, N., de Seze, M., Dinh, A., Even, A., Scheiber-Nogueira, C., Bensa, C., Bourre, B., Carra-Dallière, C., Ciron, J., Cohen, M., Guennoc, A.M., Louapre, C., Lebreton, F., Michel, L., Maillart, E., Audoin, B., Ayrignac, X., Bernady, P., Brochet, B., Clavelou, P., Colamarino, R., Declemy, A., de Seze, J., Derache, N., Faucheux, J.-M., Heinzlef, O., Labauge, P., Laplaud, D., Lepage, E., Leray, E., Magy, L., Mathey, G., Mekies, C., Mondain, V., Planque, E., Pelletier, J., Pittion, S., Stankhof, B., Tournaire, P., Thouvenot, E., Vukusic, S., Wiertlevski, S., Zephir, H., Alchaar, H., Androdias, G., Benazet, M., Bensmail, D., Biotti, D., Blanchard-Dauphin, A., Bonnan, M., Boutière, C., Branger, P., Bresch, S., Bru, J.-P., Camdessanché, J.-P., Castel Canal, E., Coustans, M., Casez, O., Castan, B., Creange, A., Creisson, E., De Broucker, T., Depaz, R., Douay, X., Dulau, C., Durand-Dubief, F., Fagniez, O., Faucher, M., Floch, A., Fournier, M., Fromont, A., Gallien, P., Gamé, X., Gault, D., Gayou, A., Giroux, M., Gout, O., Grimaud, J., Hautecoeur, P., Kerbrat, A., Kremer, L., Kwiatkowski, A., Labeyrie, C., Lachaud, S., Lanctin-Garcia, C., Lanotte, L., Manchon, E., Maurousset, A., Milor, A.-M., Moisset, X., Mont-Cuquet, A., Moreau, T., Ouallet, J.-C., Patry, I., Peaureaux, D., Pouget, M.-C., Pourcher Martinez, V., Radot, C., Ruet, A., Saint-Val, C., Salmon, A., Taithe, F., Tatevin, P., Vaillant, M., Stahl, J.-P., Vuoto, F., Zaenker, C., and Lebrun-Frenay, C.
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- 2020
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6. The Grain Number Increase 1 alleles GNI‐A1‐105Y and ‐105K increase grain number in spring wheat
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Hale, C. O., primary, Tillett, B. J., additional, Martin, J. M., additional, Hogg, A. C., additional, Cook, J. P., additional, and Giroux, M. J., additional
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- 2024
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7. Amyloid and APOE Status of Screened Subjects in the Elenbecestat MissionAD Phase 3 Program
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Roberts, Claire, Kaplow, J., Giroux, M., Krause, S., and Kanekiyo, M.
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- 2021
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8. Unravelling the Mysteries of the Leo Ring: An Absorption Line Study of an Unusual Gas Cloud
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Rosenberg, J. L., Haislmaier, Karl, Giroux, M. L., Keeney, B. A., and Schneider, S. E.
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Astrophysics - Astrophysics of Galaxies - Abstract
Since the 1980's discovery of the large (2x10^9 Msun) intergalactic cloud known as the Leo Ring, this object has been the center of a lively debate about its origin. Determining the origin of this object is still important as we develop a deeper understanding of the accretion and feedback processes that shape galaxy evolution. We present HST/COS observations of three sightlines near the Ring, two of which penetrate the high column density neutral hydrogen gas visible in 21 cm observations of the object. These observations provide the first direct measurement of the metallicity of the gas in the Ring, an important clue to its origins. Our best estimate of the metallicity of the ring is ~10% Zsun, higher than expected for primordial gas but lower than expected from an interaction. We discuss possible modifications to the interaction and primordial gas scenarios that would be consistent with this metallicity measurement., Comment: 11 pages, 7 figures, accepted ApJ
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- 2014
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9. Immunization and multiple sclerosis: Recommendations from the French Multiple Sclerosis Society
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Abadie, V., Achour, C., Ader, F., Alchaar, H., Alkhedr, A., Andreux, F., Androdias, G., Arjmand, R., Audoin, B., Audry, D., Aufauvre, D., Autreaux, C., Ayrignac, X., Bailbe, M., Benazet, M., Bensa, C., Bensmail, D., Berger, E., Bernady, P., Bertagna, Y., Biotti, D., Blanchard-Dauphin, A., Bonenfant, J., Bonnan, M., Bonnemain, B., Borgel, F., Botelho-Nevers, E., Boucly, S., Bourre, B., Boutière, C., Branger, P., Brassat, D., Bresch, S., Breuil, V., Brochet, B., Brugeilles, H., Bugnon, P., Cabre, P., Camdessanché, J.-P., Carra-Dalière, C., Casez, O., Chamouard, J.-M., Chassande, B., Chataignier, P., Chbicheb, M., Chenet, A., Ciron, J., Clavelou, P., Cohen, M., Colamarino, R., Collongues, N., Coman, I., Corail, P.-R., Courtois, S., Coustans, M., Creange, A., Creisson, E., Daluzeau, N., Davenas, C., De Seze, J., Debouverie, M., Depaz, R., Derache, N., Divio, L., Douay, X., Dulau, C., Durand-Dubief, F., Edan, G., Elias, Z., Fagniez, O., Faucher, M., Faucheux, J.-M., Fournier, M., Gagneux-Brunon, A., Gaida, P., Galli, P., Gallien, P., Gaudelus, J., Gault, D., Gayou, A., Genevray, M., Gentil, A., Gere, J., Gignoux, L., Giroux, M., Givron, P., Gout, O., Grimaud, J., Guennoc, A.-M., Hadhoum, N., Hautecoeur, P., Heinzlef, O., Jaeger, M., Jeannin, S., Kremer, L., Kwiatkowski, A., Labauge, P., Labeyrie, C., Lachaud, S., Laffont, I., Lanctin-Garcia, C., Lannoy, J., Lanotte, L., Laplaud, D., Latombe, D., Lauxerois, M., Le Page, E., Lebrun-Frenay, C., Lejeune, P., Lejoyeux, P., Lemonnier, B., Leray, E., Loche, C.-M., Louapre, C., Lubetzki, C., Maarouf, A., Mada, B., Magy, L., Maillart, E., Manchon, E., Marignier, R., Marque, P., Mathey, G., Maurousset, A., Mekies, C., Merienne, M., Michel, L., Milor, A.-M., Moisset, X., Montcuquet, A., Moreau, T., Morel, N., Moussa, M., Naudillon, J.-P., Normand, M., Olive, P., Ouallet, J.-C., Outteryck, O., Pacault, C., Papeix, C., Patry, I., Peaureaux, D., Pelletier, J., Pichon, B., Pittion, S., Planque, E., Pouget, M.-C., Pourcher, V., Radot, C., Robert, I., Rocher, F., Ruet, A., Saint-Val, C., Salle, J.-Y., Salmon, A., Sartori, E., Schaeffer, S., Stankhof, B., Taithe, F., Thouvenot, E., Tizon, C., Tourbah, A., Tourniaire, P., Vaillant, M., Vermersch, P., Vidil, S., Wahab, A., Warter, M.-H., Wiertlewski, S., Wiplosz, B., Wittwer, B., Zaenker, C., Zephir, H., Lebrun, C., and Vukusic, S.
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- 2019
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10. Radio Emissions from Substellar Companions of Evolved Cool Stars
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Ignace, R., Giroux, M. L., and Luttermoser, D. G.
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Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Solar and Stellar Astrophysics - Abstract
A number of substellar companions to evolved cool stars have now been reported. Cool giants are distinct from their progenitor Main Sequence (MS) low-mass stars in a number of ways. First, the mass loss rates of cool giant stars are orders of magnitude greater than for the late-type MS stars. Second, on the cool side of the Linsky-Haisch "dividing line", K and M giant stars are not X-ray sources, although they do show evidence for chromospheres. As a result, cool star winds are largely neutral for those spectral types, suggesting that planetary or brown dwarf magnetospheres will not be effective in standing off the stellar wind. In this case one expects the formation of a bow shock morphology at the companion, deep inside its magnetosphere. We explore radio emissions from substellar companions to giant stars with ionised winds or neutral winds.
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- 2009
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11. Dwarf Detachment and Globular Cluster Formation in Arp 305
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Hancock, M., Smith, B. J., Struck, C., Giroux, M. L., and Hurlock, S.
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Astrophysics - Cosmology and Extragalactic Astrophysics ,Astrophysics - Galaxy Astrophysics - Abstract
Tidal Dwarf Galaxies (TDG), concentrations of interstellar gas and stars in the tidal features of interacting galaxies, have been the subject of much scrutiny. The `smoking gun' that will prove the TDG hypothesis is the discovery of independent dwarf galaxies that are detached from other galaxies, but have clear tidal histories. As part of a search for TDGs we are using GALEX to conduct a large UV imaging survey of interacting galaxies selected from the Arp Atlas. As part of that study, we present a GALEX UV and SDSS and SARA optical study of the gas-rich interacting galaxy pair Arp 305. The GALEX UV data reveal much extended diffuse UV emission and star formation outside the disks including a candidate TDG between the two galaxies. We have used a smooth particle hydrodynamics code to model the interaction and determine the fate of the candidate TDG., Comment: 6 pages, 2 figures, to be published in the Proceedings of the `Galaxy Wars: Stellar Populations and Star Formation in Interacting Galaxies Conference'
- Published
- 2009
12. An Assessment of Broadband Optical Colours as Age Indicators for Star Clusters
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Hancock, M., Smith, B. J., Giroux, M. L., and Struck, C.
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Astrophysics - Abstract
We present an empirical assessment of the use of broadband optical colours as age indicators for unresolved extragalactic clusters and investigate stochastic sampling effects on integrated colours. We use the integrated properties of Galactic open clusters as models for unresolved extragalactic clusters. The population synthesis code Starburst99 (Leitherer et al. 1999) and four optical colours were used to estimate how well we can recover the ages of 62 well-studied Galactic open clusters with published ages. We provide a method for estimating the ages of unresolved clusters and for reliably determining the uncertainties in the age estimates. Our results support earlier conclusions based on comparisons to synthetic clusters, namely the (U-B) colour is critical to the estimation of the ages of star forming regions. We compare the observed optical colours with those obtained from Starburst99 using the published ages and get good agreement. The scatter in the (B-V)_observed-(B-V)_model is larger for lower luminosity clusters, perhaps due to stochastic effects., Comment: 9 pages, 6 figures, 2 tables, accepted for publication in MNRAS on 7/7/08
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- 2008
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13. Stochastic `Beads on a String' in the Accretion Tail of Arp 285
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Smith, B. J., Struck, C., Hancock, M., Giroux, M. L., Appleton, P. N., Charmandaris, V., Reach, W., Hurlock, S., and Hwang, J. -S.
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Astrophysics - Abstract
We present Spitzer infrared, GALEX UV, and SDSS and SARA optical images of the peculiar interacting galaxy pair Arp 285 (NGC 2856/4), and compare with a new numerical model of the interaction. We estimate the ages of clumps of star formation in these galaxies using population synthesis models, carefully considering the uncertainties on these ages. This system contains a striking example of `beads on a string': a series of star formation complexes ~1 kpc apart. These `beads' are found in a tail-like feature that is perpendicular to the disk of NGC 2856, which implies that it was formed from material accreted from the companion NGC 2854. The extreme blueness of the optical/UV colors and redness of the mid-infrared colors implies very young stellar ages (~4 - 20 Myrs) for these star forming regions. Spectral decomposition of these `beads' shows excess emission above the modeled stellar continuum in the 3.6 micron and 4.5 micron bands, indicating either contributions from interstellar matter to these fluxes or a second older stellar population. These clumps have -12.0 < M(B) < -10.6, thus they are less luminous than most dwarf galaxies. Our model suggests that bridge material falling into the potential of the companion overshoots the companion. The gas then piles up at apo-galacticon before falling back onto the companion, and star formation occurs in the pile-up. A luminous (M(B) ~ -13.6) extended (FWHM ~ 1.3 kpc) `bright spot' is visible at the northwestern edge of the NGC 2856 disk, with an intermediate stellar population (400 - 1500 Myrs). Our model suggests that this feature is part of a expanding ripple-like `arc' created by an off-center ring-galaxy-like collision between the two disks., Comment: Accepted by the Astronomical Journal. For color figures and appendix material, go tohttp://www.etsu.edu/physics/bsmith/research/sg/arp285/arp285.html
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- 2008
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14. Metallicity and Ionization in High Velocity Cloud Complex C
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Collins, J. A., Shull, J. M., and Giroux, M. L.
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Astrophysics - Abstract
We analyze HST and FUSE ultraviolet spectroscopic data for eleven sight lines passing through the infalling high velocity cloud (HVC) Complex C. These sight lines pass through regions with HI column densities ranging from N(HI) = 10^(18.1) to 10^(20.1). From [OI/HI] abundances, we find that Complex C metallicities range from 0.09 to 0.29 Z_solar, with a column density weighted mean of 0.13 Z_solar. Nitrogen (NI) is underabundant by factors of (0.01-0.07) (N/H)_solar, significantly less than oxygen relative to solar abundances. This pattern suggests nucleosynthetic enrichment by Type II SNe, consistent with an origin in the Galactic fountain or infalling gas produced in winds from Local Group galaxies. The range of metallicity and its possible (2 sigma) dependence on N(HI) could indicate some mixing of primordial material with enriched gas from the Milky Way, but the mixing mechanism is unclear. We also investigate the significant highly ionized component of Complex C, detected in CIV, SiIV, and OVI, but not in NV. High-ion column density ratios show little variance and are consistent with shock ionization or ionization at interfaces between Complex C and a hotter surrounding medium. Evidence for the former mechanism is seen in the Mrk 876 line profiles, where the offset in line centroids between low and high ions suggests a decelerating bowshock., Comment: Submitted to ApJ
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- 2006
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15. The UV spectrum of HS1700+6416 II. FUSE observations of the HeII Lyman alpha forest
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Fechner, C., Reimers, D., Kriss, G. A., Baade, R., Blair, W. P., Giroux, M. L., Green, R. F., Moos, H. W., Morton, D. C., Scott, J. E., Shull, J. M., Simcoe, R., Songaila, A., and Zheng, W.
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Astrophysics - Abstract
We present the far-UV spectrum of the quasar HS1700+6416 taken with FUSE. This QSO provides the second line of sight with the HeII absorption resolved into a Ly alpha forest structure. Since HS1700+6416 is slightly less redshifted (z=2.72) than HE2347-4342, we only probe the post-reionization phase of HeII, seen in the evolution of the HeII opacity, which is consistent with a simple power law. The HeII/HI ratio eta is estimated using a line profile-fitting procedure and an apparent optical depth approach, respectively. The expected metal line absorption in the far-UV is taken into account as well as molecular absorption of galactic H_2. About 27% of the eta values are affected by metal line absorption. In order to investigate the applicability of the analysis methods, we create simple artificial spectra based on the statistical properties of the HI Ly alpha forest. The analysis of the artificial data demonstrates that the apparent optical depth method as well as the line profile-fitting procedure lead to confident results for restricted data samples only (12.0 < log N(HI) < 13.0). The reasons are saturation in the case of the apparent optical depth and thermal line widths in the case of the profile fits. Furthermore, applying the methods to the unrestricted data set may mimic a correlation between eta and the strength of the HI absorption. For the restricted data samples a scatter of 10 - 15% in eta would be expected even if the underlying value is constant. The observed scatter is significantly larger than expected, indicating that the intergalactic radiation background is indeed fluctuating. In the redshift range 2.58 < z < 2.72, where the data quality is best, we find eta ~ 100, suggesting a contribution of soft sources like galaxies to the UV background., Comment: 18 pages, 14 figures, accepted for publication in A&A
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- 2006
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16. Probing Star Formation in Interacting Galaxies Using UV and Mid-IR: The Case of Arp 82
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Hancock, M., Smith, B. J., Struck, C., Giroux, M., Appleton, P., Reach, W., and Charmandaris, V.
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Astrophysics - Abstract
To help understand the effects of galaxy interactions on star formation, we analyze Spitzer infrared and GALEX ultraviolet images of the interacting galaxy pair Arp 82 (NGC 2535/6), and compare to a numerical simulation of the interaction. We investigate the UV and IR properties of several star forming regions (clumps). Using the FUV/NUV colors of the clumps we constrain the ages. The 8 micron and 24 micron luminosities are used to estimate the far-infrared luminosities and the star formation rates of the clumps. We investigate possible gradients in the UV and IR colors. See Smith et al. (2006a,b) for global results on our entire interacting sample., Comment: 4 pages, 8 figures
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- 2006
17. Highly Ionized High-Velocity Clouds: Hot Intergalactic Medium or Galactic Halo?
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Collins, J. A., Shull, J. M., and Giroux, M. L.
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Astrophysics - Abstract
We use spectroscopic data from HST and FUSE to study the wide range of ionization states of the "highly ionized high-velocity clouds". Studied extensively in OVI absorption, these clouds are usually assumed to be infalling gas in the Galactic halo at distances less than 50 kpc. An alternative model attributes the OVI (and OVII X-ray absorption) to cosmological structures of low-density, shock-heated intergalactic gas, distributed over 1-3 Mpc surrounding the Milky Way. The latter interpretation is unlikely, owing to the enormous required mass of gas (4x10^12 M_solar). Our detection, in 9 of 12 sight lines, of low ionization stages (CII/III/IV; SiII/III/IV) at similar high velocities as OVI requires gas densities far above that (n_H=5x10^-6 cm^-3) associated with the warm-hot intergalactic medium (WHIM). These HVCs are probably cooling, multiphase gas in the Galactic halo, bow-shocks and interfaces between clouds falling through a hot, rotating gaseous halo. The velocity segregation of these HVCs in Galactic coordinates is consistent with a pattern in which infalling clouds reflect the sense of Galactic rotation, with peculiar velocities superposed., Comment: 26 pages, 1 color figure. Accepted for publication in ApJ. Replaced original version with emulateapj style
- Published
- 2005
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18. Discovery of a Dwarf Post-Starburst Galaxy Near a High Column Density Ly-alpha Absorber
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Stocke, J. T., Keeney, B. A., McLin, K. M., Rosenberg, J. L., Weymann, R. J., and Giroux, M. L.
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Astrophysics - Abstract
We report the discovery of a dwarf (M_B = -13.9) post-starburst galaxy coincident in recession velocity (within uncertainties) with the highest column density absorber (N_HI = 10^15.85 cm^{-2} at cz = 1586 km/s) in the 3C~273 sightline. This galaxy is by far the closest galaxy to this absorber, projected just 71 kpc on the sky from the sightline. The mean properties of the stellar populations in this galaxy are consistent with a massive starburst ~3.5 Gyrs ago, whose attendant supernovae, we argue, could have driven sufficient gas from this galaxy to explain the nearby absorber. Beyond the proximity on the sky and in recession velocity, the further evidence in favor of this conclusion includes both a match in the metallicities of absorber and galaxy, and the fact that the absorber has an overabundance of Si/C, suggesting recent type II supernova enrichment. Thus, this galaxy and its ejecta are the expected intermediate stage in the fading dwarf evolutionary sequence envisioned by Babul & Rees to explain the abundance of faint blue galaxies at intermediate redshifts., Comment: 33 pages, 4 figures, ApJ in press
- Published
- 2004
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19. A Study of the Reionization History of Intergalactic Helium with FUSE and VLT
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Zheng, W., Kriss, G. A., Deharveng, J. -M., Dixon, W. V., Kruk, J. W., Shull, J. M., Giroux, M. L., Morton, D. C., Williger, G. M., Friedman, S. D., and Moos, H. W.
- Subjects
Astrophysics - Abstract
We obtained high-resolution VLT and FUSE spectra of the quasar HE2347-4342 to study the properties of the intergalactic medium between redshifts z=2.0-2.9. The high-quality optical spectrum allows us to identify approximately 850 HeII absorption components with column densities between N~5X10^11 and $ 10^18 cm^-2. The reprocessed FUSE spectrum extends the wavelength coverage of the HeII absorption down to an observed wavelength of 920 A. Approximately 1400 HeII absorption components are identified, including 917 HeII Ly-alpha systems and some of their HeII Ly-beta, Ly-gamma, and Ly-delta counterparts. The ionization structure of HeII is complex, with approximately 90 components that are not detected in the hydrogen spectrum. These components may represent the effect of soft ionizing sources. The ratio Eta=N(HeII)/N(HI) varies approximately from unity to more than a thousand, with a median value of 62 and a distribution consistent with the intrinsic spectral indices of quasars. This suggests that the dominant ionizing field is from the accumulated quasar radiation, with contributions from other soft sources such as star-forming regions and obscured AGN, which do not ionize helium. We find an evolution in Eta toward smaller values at lower redshift, with the gradual disappearance of soft components. At redshifts z>2.7, the large but finite increase in the HeII opacity, Tau=5+/-1, suggests that we are viewing the end stages of a reionization process that began at an earlier epoch. Fits of the absorption profiles of unblended lines indicate comparable velocities between hydrogen and He^+ ions. At hydrogen column densities N<3X10^12 cm^-2 the number of forest lines shows a significant deficit relative to a power law, and becomes negligible below N=10^11 cm^-2., Comment: 40 pages, 10 Postscript figures, uses Aastex.sty The Astrophysical Journal, in press
- Published
- 2003
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20. Highly Ionized High-Velocity Clouds toward PKS 2155-304 and Markarian 509
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Collins, J. A., Shull, J. M., and Giroux, M. L.
- Subjects
Astrophysics - Abstract
To gain insight into four highly ionized high-velocity clouds (HVCs) discovered by Sembach et al. (1999), we have analyzed data from the Hubble Space Telescope (HST) and Far Ultraviolet Spectroscopic Explorer (FUSE) for the PKS 2155-304 and Mrk 509 sight lines. We measure strong absorption in OVI and column densities of multiple ionization stages of silicon (SiII/III/IV) and carbon (CII/III/IV). We interpret this ionization pattern as a multiphase medium that contains both collisionally ionized and photoionized gas. Toward PKS 2155-304, for HVCs at -140 and -270 km/s, respectively, we measure logN(OVI)=13.80+/-0.03 and log N(OVI)=13.56+/-0.06; from Lyman series absorption, we find log N(HI)=16.37^(+0.22)_(-0.14) and 15.23^(+0.38)_(-0.22). The presence of high-velocity OVI spread over a broad (100 km/s) profile, together with large amounts of low-ionization species, is difficult to reconcile with the low densities, n=5x10^(-6) cm^(-3), in the collisional/photoionization models of Nicastro et al. (2002), although the HVCs show a similar relation in N(SiIV)/N(CIV) versus N(CII)/N(CIV) as high-z intergalactic clouds. Our results suggest that the high-velocity OVI in these absorbers do not necessarily trace the WHIM, but instead may trace HVCs with low total hydrogen column density. We propose that the broad high-velocity OVI absorption arises from shock ionization, at bowshock interfaces produced from infalling clumps of gas with velocity shear. The similar ratios of high ions for HVC Complex C and these highly ionized HVCs suggest a common production mechanism in the Galactic halo., Comment: 38 pages, including 10 figures. ApJ, 10 April, 2004. Replaced with accepted version
- Published
- 2003
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21. Probing the Size of Low-Redshift Lyman-alpha Absorbers
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Rosenberg, J. L., Ganguly, R., Giroux, M. L., and Stocke, J. T.
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Astrophysics - Abstract
The 3C 273 and RX J1230.8+0115 sightlines probe the outskirts of the Virgo Cluster at physical separations between the sightlines of 200-500 h_70 kpc. We present an analysis of HST STIS echelle and FUSE UV spectroscopy of RX J1230.8+0115 in which we detect five Lyman-alpha absorbers at Virgo distances. One of these absorbers is a blend of two strong metal line absorbers coincident in velocity with the highest neutral hydrogen column density absorber in the 3C 273 sightline ~350 h_70 kpc away. The consistency of the metal line column density ratios in the RX J1230.8+0115 sightline allows us to determine the ionization mechanism (photoionization) for these absorbers. While the low signal-to-noise ratio of the FUSE spectrum limits our ability to model the neutral hydrogen column density of these absorbers, we are able to constrain them to be in the range 10^{16-17} cm^-2. The properties of these absorbers are similar to those of the 3C 273 absorber studied by Tripp et al. However, the inferred line-of-sight size for the 3C 273 absorber is only 70 pc, much smaller than those inferred in RX J1230.8+0115, which are 10-30 h_70 kpc. The small sizes of all three absorbers are at odds with the >~350 h_70 kpc minimum transverse size implied by an application of the standard QSO line pairs analysis. On the basis of absorber associations between these two sight lines we conclude that a large-scale structure filament produces a correlated, not contiguous, gaseous structure in this region of the Virgo Supercluster. These data may indicate that we are detecting overdensities in the large scale structure filaments in this region. Alternatively, the presence of a galaxy 71 h_70 kpc from a 3C 273 absorber may indicate that we have probed outflowing, starburst driven shells of gas associated with nearby galaxies., Comment: 13 pages, accepted ApJ
- Published
- 2003
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22. Yield increases resulting from AGPase overexpression in rice are reliant on plant nutritional status
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Oiestad, A. J., Martin, J. M., and Giroux, M. J.
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- 2019
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23. A Survey of FUSE and HST Sightlines through High-Velocity Cloud Complex C
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Collins, J. A., Shull, J. M., and Giroux, M. L.
- Subjects
Astrophysics - Abstract
Using archival Far Ultraviolet Spectroscopic Explorer (FUSE) and Hubble Space Telescope (HST) data, we have assembled a survey of eight sightlines through high-velocity cloud Complex C. Abundances of the observed ion species vary significantly for these sightlines, indicating that Complex C is not well characterized by a single metallicity. Reliable metallicities based on [OI/HI] range from 0.1-0.25 solar. Metallicities based on [SII/HI] range from 0.1-0.6 solar, but the trend of decreasing abundance with HI column density indicates that photoionization corrections may affect the conversion to [S/H]. We present models of the dependence of the ionization correction on HI column density; these ionization corrections are significant when converting ion abundances to elemental abundances for S, Si, and Fe. The measured abundances in this survey indicate that parts of the cloud have a higher metallicity than previously thought and that Complex C may represent a mixture of ``Galactic fountain'' gas with infalling low-metallicity gas. We find that [S/O] and [Si/O] have a solar ratio, suggesting little dust depletion. Further, the measured abundances suggest an over-abundance of O, S, and Si relative to N and Fe. The enhancement of these alpha-elements suggests that the bulk of the metals in Complex C were produced by Type II supernovae and then removed from the star-forming region, possibly via supernovae-driven winds or tidal stripping, before the ISM could be enriched by N and Fe., Comment: 50 pages, 17 figures. Accepted to ApJ. Previous version was the first submitted manuscript
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- 2002
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24. Resolving the Structure of Ionized Helium in the Intergalactic Medium with the Far Ultraviolet Spectroscopic Explorer
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Kriss, G. A., Shull, J. M., Oegerle, W., Zheng, W., Davidsen, A. F., Songaila, A., Tumlinson, J., Cowie, L. L., Deharveng, J. -M., Friedman, S. D., Giroux, M. L., Green, R. F., Hutchings, J. B., Jenkins, E. B., Kruk, J. W., Moos, H. W., Morton, D. C., Sembach, K. R., and Tripp, T. M.
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Astrophysics - Abstract
The neutral hydrogen and the ionized helium absorption in the spectra of quasars are unique probes of structure in the early universe. We present Far-Ultraviolet Spectroscopic Explorer observations of the line of sight to the quasar HE2347-4342 in the 1000-1187 A band at a resolving power of 15,000. We resolve the He II Ly alpha absorption as a discrete forest of absorption lines in the redshift range 2.3 to 2.7. About 50 percent of these features have H I counterparts with column densities log N(HI) > 12.3 that account for most of the observed opacity in He II Ly alpha. The He II to H I column density ratio ranges from 1 to >1000 with an average of ~80. Ratios of <100 are consistent with photoionization of the absorbing gas by a hard ionizing spectrum resulting from the integrated light of quasars, but ratios of >100 in many locations indicate additional contributions from starburst galaxies or heavily filtered quasar radiation. The presence of He II Ly alpha absorbers with no H I counterparts indicates that structure is present even in low-density regions, consistent with theoretical predictions of structure formation through gravitational instability., Comment: 8 pages, 4 PostScript figures, uses aaspp4.sty. Appearing in Science, Vol. 293, Issue 5532, August 10, 2001
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- 2001
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25. Airway microbiota signals anabolic and catabolic remodeling in the transplanted lung
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Jougon, J., Velly, J.-F., Rozé, H., Blanchard, E., Dromer, C., Antoine, M., Cappello, M., Ruiz, M., Sokolow, Y., Vanden Eynden, F., Van Nooten, G., Barvais, L., Berré, J., Brimioulle, S., De Backer, D., Créteur, J., Engelman, E., Huybrechts, I., Ickx, B., Preiser, T.J.C., Tuna, T., Van Obberghe, L., Vancutsem, N., Vincent, J.-L., De Vuyst, P., Etienne, I., Féry, F., Jacobs, F., Knoop, C., Vachiéry, J.L., Van den Borne, P., Wellemans, I., Amand, G., Collignon, L., Giroux, M., Angelescu, D., Chavanon, O., Hacini, R., Pirvu, A., Porcu, P., Albaladejo, P., Allègre, C., Bataillard, A., Bedague, D., Briot, E., Casez-Brasseur, M., Colas, D., Dessertaine, G., Durand, M., Francony, G., Hebrard, A., Marino, M.R., Oummahan, B., Protar, D., Rehm, D., Robin, S., Rossi-Blancher, M., Augier, C., Bedouch, P., Boignard, A., Bouvaist, H., Briault, A., Camara, B., Claustre, J., Chanoine, S., Dubuc, M., Quétant, S., Maurizi, J., Pavèse, P., Pison, C., Saint-Raymond, C., Wion, N., Chérion, C., Grima, R., Jegaden, O., Maury, J.-M., Tronc, F., Flamens, C., Paulus, S., Mornex, J.-F., Philit, F., Senechal, A., Glérant, J.-C., Turquier, S., Gamondes, D., Chalabresse, L., Thivolet-Bejui, F., Barnel, C., Dubois, C., Tiberghien, A., Le Pimpec-Barthes, F., Bel, A., Mordant, P., Achouh, P., Boussaud, V., Guillemain, R., Méléard, D., Bricourt, M.O., Cholley, B., Pezella, V., Brioude, G., D'Journo, X.B., Doddoli, C., Thomas, P., Trousse, D., Dizier, S., Leone, M., Papazian, L., Bregeon, F., Basire, A., Coltey, B., Dufeu, N., Dutau, H., Garcia, S., Gaubert, J.Y., Gomez, C., Laroumagne, S., Nieves, A., Picard, L.C., Reynaud-Gaubert, M., Secq, V., Mouton, G., Baron, O., Lacoste, P., Perigaud, C., Roussel, J.C., Danner, I., Haloun, A., Magnan, A., Tissot, A., Lepoivre, T., Treilhaud, M., Botturi-Cavaillès, K., Brouard, S., Danger, R., Loy, J., Morisset, M., Pain, M., Pares, S., Reboulleau, D., Royer, P.-J., Fabre, D., Fadel, E., Mercier, O., Mussot, S., Stephan, F., Viard, P., Cerrina, J., Dorfmuller, P., Ghigna, S.M., Hervén, Ph., Le Roy Ladurie, F., Le Pavec, J., Thomas de Montpreville, V., Lamrani, L., Castier, Y., Cerceau, P., Augustin, P., Jean-Baptiste, S., Boudinet, S., Montravers, P., Brugière, O., Dauriat, G., Jébrak, G., Mal, H., Marceau, A., Métivier, A.-C., Thabut, G., Lhuillier, E., Dupin, C., Bunel, V., Falcoz, P., Massard, G., Santelmo, N., Ajob, G., Collange, O., Helms, O., Hentz, J., Roche, A., Bakouboula, B., Degot, T., Dory, A., Hirschi, S., Ohlmann-Caillard, S., Kessler, L., Kessler, R., Schuller, A., Bennedif, K., Vargas, S., Stauder, J., Ali-Azouaou, S., Bonnette, P., Chapelier, A., Puyo, P., Sage, E., Bresson, J., Caille, V., Cerf, C., Devaquet, J., Dumans-Nizard, V., Felten, M.-L., Fischler, M., Si Larbi, A.-G., Leguen, M., Ley, L., Liu, N., Trebbia, G., De Miranda, S., Douvry, B., Gonin, F., Grenet, D., Hamid, A.M., Neveu, H., Parquin, F., Picard, C., Roux, A., Stern, M., Bouillioud, F., Cahen, P., Colombat, M., Dautricourt, C., Delahousse, M., D'Urso, B., Gravisse, J., Guth, A., Hillaire, S., Honderlick, P., Lequintrec, M., Longchampt, E., Mellot, F., Scherrer, A., Temagoult, L., Tricot, L., Vasse, M., Veyrie, C., Zemoura, L., Berjaud, J., Brouchet, L., Dahan, M., Mathe, F.O., Benahoua, H., DaCosta, M., Serres, I., Merlet-Dupuy, V., Grigoli, M., Didier, A., Murris, M., Crognier, L., Fourcade, O., Krueger, T., Ris, H.B., Gonzalez, M., Jolliet, Ph., Marcucci, C., Chollet, M., Gronchi, F., Courbon, C., Berutto, C., Manuel, O., Koutsokera, A., Aubert, J.-D., Nicod, L.P., Mouraux, S., Bernasconi, E., Pattaroni, C., Marsland, B.J., Soccal, P.M., Rochat, T., Lücker, L.M., Hillinger, S., Inci, I., Weder, W., Schuepbach, R., Zalunardo, M., Benden, C., Schuurmans, M.M., Gaspert, A., Holzmann, D., Müller, N., Schmid, C., Vrugt, B., Fritz, A., Maier, D., Deplanche, K., Koubi, D., Ernst, F., Paprotka, T., Schmitt, M., Wahl, B., Boissel, J.-P., Olivera-Botello, G., Trocmé, C., Toussaint, B., Bourgoin-Voillard, S., Sève, M., Benmerad, M., Siroux, V., Slama, R., Auffray, C., Charron, D., Lefaudeux, D., Pellet, J., Mouraux, Stéphane, Bernasconi, Eric, Pattaroni, Céline, Koutsokera, Angela, Aubert, John-David, Claustre, Johanna, Pison, Christophe, Royer, Pierre-Joseph, Magnan, Antoine, Kessler, Romain, Benden, Christian, Soccal, Paola M., Marsland, Benjamin J., and Nicod, Laurent P.
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- 2018
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26. FUSE Observations of the Low-Redshift Lyman-beta Forest
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Shull, J. M., Giroux, M. L., Penton, S. V., Tumlinson, J., Stocke, J. T., Jenkins, E. B., Moos, H. W., Oegerle, W. R., Savage, B. D., Sembach, K. R., York, D. G., Green, J. C., and Woodgate, B. E.
- Subjects
Astrophysics - Abstract
We describe a moderate-resolution (20-25 km/s) FUSE study of the low-redshift intergalactic medium. We report on studies of 7 extragalactic sightlines and 12 Ly-beta absorbers that correspond to Ly-alpha lines detected by HST/GHRS and STIS. These absorbers appear to contain a significant fraction of the low-z baryons and were a major discovery of the HST spectrographs. Using FUSE data, with 40 mA (4-sigma) Lyb detection limits, we have employed the equivalent width ratio of Lyb/Lya and occasionally higher Lyman lines, to determine the doppler parameter, b, and accurate column densities, N(HI), for moderately saturated lines. We detect Lyb absorption corresponding to all Lya lines with EW > 200 mA. The Lyb/Lya ratios yield a preliminary distribution function of doppler parameters, with mean = 31.4 +/- 7.4 km/s and median b = 28 km/s, comparable to values at redshifts z = 2.0-2.5. If thermal, these b-values correspond to T(HI) ~ 50,000 K, although the inferred doppler parameters are considerably less than the widths derived from Lya profile fitting, = 0.52. The typical increase in column density over that derived from profile fitting is Delta[log N(HI)] = 0.3, but ranges up to 1.0 dex. Our data suggest that the low-z Lya absorbers contain sizable non-thermal motions or velocity components in the line profile, perhaps arising from cosmological expansion and infall., Comment: To appear in ApJL (FUSE first-results issue), 4 pages + 3 figures (.ps)
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- 2000
27. The Metagalactic Ionizing Radiation Field at Low Redshift
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Shull, J. M., Roberts, D., Giroux, M. L., Penton, S. V., and Fardal, M. A.
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Astrophysics - Abstract
We compute the ionizing radiation field at low redshift, arising from Seyferts, QSOs, and starburst galaxies. This calculation combines recent Seyfert luminosity functions, extrapolated ultraviolet fluxes from our IUE-AGN database, and a new intergalactic opacity model based on Hubble Space Telescope and Keck Ly-alpha absorber surveys. At z = 0 for AGN only, our best estimate for the specific intensity at 1 Ryd is I_0 = 1.3 (+0.8/-0.5) x 10^-23 ergs/cm^2/s/Hz/sr, independent of H_0, Omega_0, and Lambda. The one-sided ionizing photon flux is Phi_ion = 3400 (+2100/-1300) photons/cm^2/s, and the H I photoionization rate is Gamma_HI = 3.2 (+2.0/-1.2) x 10^-14 s^-1 for alpha_s = 1.8. We also derive Gamma_ HI for z = 0 - 4. These error ranges reflect uncertainties in the spectral indexes for the ionizing EUV (alpha_s = 1.8 +/- 0.3) and the optical/UV (alpha_UV = 0.86 +/- 0.05), the IGM opacity model, the range of Seyfert luminosities (0.001 - 100 L*) and the completeness of the luminosity functions. Our estimate is a factor of three lower than the most stringent upper limits on the ionizing background (Phi_ion < 10^4 photons/cm^2/s) obtained from H-alpha observations in external clouds, and it lies within the range implied by other indirect measures. Starburst galaxies with a sufficiently large Lyman continuum escape fraction, f_ esc > 0.05, may provide a comparable background to AGN, I_0 (z=0) = 1.1 (+1.5/-0.7) x 10^{-23). An additional component of the ionizing background of this magnitude would violate neither upper limits from H-alpha observations nor the acceptable range from other measurements., Comment: 30 pages, 9 figures, accepted for Astronomical J. (Oct. 1999)
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- 1999
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28. The Grain Number Increase 1alleles GNI‐A1‐105Y and ‐105K increase grain number in spring wheat
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Hale, C. O., Tillett, B. J., Martin, J. M., Hogg, A. C., Cook, J. P., and Giroux, M. J.
- Abstract
Wheat (Triticum aestivumL.) has inflorescences made up of multiple spikelets arranged along a central rachis, with each spikelet producing between one and four grains. The Grain Number Increase 1(GNI‐A1) gene wheat directly influences grain number per spikelet and grain size. Three naturally occurring alleles have been described previously: GNI‐A1‐105N, 105Y, and 105K. This project's goal was to characterize the impact of these alleles within hard red spring wheat cultivars in Montana, where each of the alleles is common. The 105N allele and the 105K allele were compared through analysis of an F5Vida by Spring‐Yellowstone recombinant inbred line (RIL) population, and with near isogenic lines (NILs) derived from the same population. The 105N allele and the 105Y allele were compared with NILs derived from an F4Lanning by Egan RIL population. We analyzed the impact of each of the three alleles and compared their effects on inflorescence architecture, grain size, grain yield, grain quality, and milling quality under Bozeman, MT, field conditions. Data show that either loss‐of‐function alleles (105Y and 105K) increased grain number per spikelet by 5% when compared to the more functional allele (105N) across all years and environments tested. Overall grain size was not significantly reduced and there was also not a significant increase in overall grain yield. The wheat Grain Number Increase 1gene increases grain number per spikelet.Grain Number Increase 1missense alleles increased grain number per inflorescence by 5%.Grain Number Increase 1missense alleles did not increase grain yield.
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- 2024
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29. Abstract No. 150 Endovascular Treatment of Pelvic Congestion Syndrome (PCS) in 246 women, Long Term Results, and Analysis of Patient Satisfaction
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Bentridi, A., primary, Hazout, S., additional, Tradi, F., additional, Hadjadj, A., additional, Gilbert, P., additional, Therasse, E., additional, Giroux, M., additional, and Soulez, G., additional
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- 2023
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30. Wheat
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Meyer, F. D., Giroux, M. J., Nagata, Toshiyuki, editor, Lörz, Horst, editor, Widholm, Jack M., editor, Pua, Eng-Chong, editor, and Davey, Michael R., editor
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- 2007
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31. The impact of a standardized order set for the management of non-hip fragility fractures in a Fracture Liaison Service
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Senay, A., Delisle, J., Giroux, M., Laflamme, G. Y., Leduc, S., Malo, M., Nguyen, H., Ranger, P., and Fernandes, J. C.
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- 2016
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32. Correction to: Genetic characterization and expression analysis of wheat (Triticum aestivum) line 07OR1074 exhibiting very low polyphenol oxidase (PPO) activity
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Hystad, S. M., Martin, J. M., Graybosch, R. A., and Giroux, M. J.
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- 2020
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33. 405 CORRELATION OF ANORECTAL SYMPTOMS AND ENDOANAL ULTRASOUND FINDINGS AFTER OBSTETRICAL ANAL SPHINCTER INJURIES (OASIS)
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Naqvi, N, Giroux, M, and Alarab, M
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- 2022
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34. Genetic characterization and expression analysis of wheat (Triticum aestivum) line 07OR1074 exhibiting very low polyphenol oxidase (PPO) activity
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Hystad, S. M., Martin, J. M., Graybosch, R. A., and Giroux, M. J.
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- 2015
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35. The Impact of Same versus Different Price Presentation on Travel Choice and the Moderating Role of Childhood Socioeconomic Status
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Giroux, M, Franklin, D, Kim, J, Park, J, Kwak, K, Giroux, M, Franklin, D, Kim, J, Park, J, and Kwak, K
- Abstract
When making travel decisions, consumers are frequently exposed to a multitude of options, including differing price levels for the same product or service across a range of online travel agencies. The current research investigates how the magnitude of price dispersion in online pricing can influence travelers’ product evaluations and purchase intentions. Specifically, we predict that travelers will prefer a hotel with no price dispersion to a hotel with different prices listed when the price difference is small, or narrow. However, when the price difference is more pronounced, or wide, travelers will prefer a hotel with price differences compared to a hotel with no price dispersion. Four experiments demonstrate that this effect is consistent across different contexts and categories. Additionally, based on life history theory, we argue that the relative preference for the same versus different price dispersion will be moderated by the travelers’ childhood socioeconomic status (SES).
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- 2022
36. How can progress towards Ending the HIV Epidemic in the United States be monitored?
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Mitchell, KM, Maheu-Giroux, M, Dimitrov, D, Moore, M, Hughes, JP, Donnell, D, Beyrer, C, El-Sadr, WM, Cohen, MS, Boily, MC, Medical Research Council (MRC), and National Institutes of Health
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RISK ,Science & Technology ,HIV INCIDENCE ,estimates ,Immunology ,HIV ,surveillance data ,HIV Infections ,06 Biological Sciences ,Microbiology ,United States ,TIME ,Infectious Diseases ,Cross-Sectional Studies ,incidence surveys ,SURVEILLANCE ,Humans ,infections ,Longitudinal Studies ,Epidemics ,Life Sciences & Biomedicine ,POPULATION ,11 Medical and Health Sciences - Abstract
The plan for Ending the HIV Epidemic (EHE) in the United States aims to reduce new infections by 75% by 2025 and by 90% by 2030. For EHE to be successful, it is important to accurately measure changes in numbers of new HIV infections after 5 and 10 years (to determine whether the EHE goals have been achieved) but also over shorter time-scales (to monitor progress and intensify prevention efforts if required). In this viewpoint, we aim to demonstrate why the method used to monitor progress towards the EHE goals needs to be carefully considered. We briefly describe and discuss different methods to estimate numbers of new HIV infections, based on longitudinal cohort studies, cross-sectional incidence surveys and routine surveillance data. We particularly focus on identifying conditions under which unadjusted and adjusted estimates based on routine surveillance data can be used to estimate changes in new HIV infections.
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- 2021
37. High-affinity σ1 protein agonist reduces clinical and pathological signs of experimental autoimmune encephalomyelitis
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Oxombre, B, Lee-Chang, C, Duhamel, A, Toussaint, M, Giroux, M, Donnier-Maréchal, M, Carato, P, Lefranc, D, Zéphir, H, Prin, L, Melnyk, P, and Vermersch, P
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- 2015
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38. The TGF-β-Smad3 pathway inhibits CD28-dependent cell growth and proliferation of CD4 T cells
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Delisle, J-S, Giroux, M, Boucher, G, Landry, J-R, Hardy, M-P, Lemieux, S, Jones, R G, Wilhelm, B T, and Perreault, C
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- 2013
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39. Estimating C inputs retained as soil organic matter from corn (Zea Mays L.)
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Bolinder, M.A., Angers, D.A., Giroux, M., and Laverdière, M.R.
- Published
- 1999
40. Differential expression of SMAD3 transcripts is not regulated by cis-acting genetic elements but has a gender specificity
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Busque, L, Belisle, C, Provost, S, Giroux, M, and Perreault, C
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- 2009
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41. Creation and functional analysis of new Puroindoline alleles in Triticum aestivum
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Feiz, L., Martin, J. M., and Giroux, M. J.
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- 2009
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42. In planta mutagenesis determines the functional regions of the wheat puroindoline proteins
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Feiz, L., Beecher, B. S., Martin, J. M., and Giroux, M. J.
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Gene mutations -- Research ,Population genetics -- Research ,Wheat -- Physiological aspects ,Wheat -- Genetic aspects ,Proteins -- Structure ,Proteins -- Analysis ,Biological sciences - Published
- 2009
43. Describing, analysing and understanding the effects of the introduction of HIV self-testing in West Africa through the ATLAS programme in Cote d'Ivoire, Mali and Senegal
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Rouveau, N, Ky-Zerbo, O, Boye, S, Fotso, AS, D'Elbée, M, Maheu-Giroux, M, Silhol, R, Kouassi, AK, Vautier, A, Doumenc-Aïdara, C, Breton, G, Keita, A, Ehui, E, Ndour, CT, Boilly, M-C, Terris-Prestholt, F, Pourette, D, Desclaux, A, Larmarange, J, ATLAS Team, and Solidarite Therapeutiq Initiative Sida
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WESTERN_AFRICA ,IVORY_COAST ,Côte d’Ivoire ,lcsh:Public aspects of medicine ,HIV self-testing ,HIV ,lcsh:RA1-1270 ,ATLAS Team ,Mali ,Senegal ,1117 Public Health and Health Services ,AIDS ,Cote d'Ivoire ,TESTS ,West Africa ,HIV/AIDS ,Public Health - Abstract
Background The ATLAS programme aims to promote and implement HIV self-testing (HIVST) in three West African countries: Côte d’Ivoire, Mali, and Senegal. During 2019–2021, in close collaboration with the national AIDS implementing partners and communities, ATLAS plans to distribute 500,000 HIVST kits through eight delivery channels, combining facility-based, community-based strategies, primary and secondary distribution of HIVST. Considering the characteristics of West African HIV epidemics, the targets of the ATLAS programme are hard-to-reach populations: key populations (female sex workers, men who have sex with men, and drug users), their clients or sexual partners, partners of people living with HIV and patients diagnosed with sexually transmitted infections and their partners. The ATLAS programme includes research support implementation to generate evidence for HIVST scale-up in West Africa. The main objective is to describe, analyse and understand the social, health, epidemiological effects and cost-effectiveness of HIVST introduction in Côte d’Ivoire, Mali and Senegal to improve the overall HIV testing strategy (accessibility, efficacy, ethics). Methods ATLAS research is organised into five multidisciplinary workpackages (WPs): Key Populations WP: qualitative surveys (individual in-depth interviews, focus group discussions) conducted with key actors, key populations, and HIVST users. Index testing WP: ethnographic observation of three HIV care services introducing HIVST for partner testing. Coupons survey WP: an anonymous telephone survey of HIVST users. Cost study WP: incremental economic cost analysis of each delivery model using a top-down costing with programmatic data, complemented by a bottom-up costing of a representative sample of HIVST distribution sites, and a time-motion study for health professionals providing HIVST. Modelling WP: Adaptation, parameterisation and calibration of a dynamic compartmental model that considers the varied populations targeted by the ATLAS programme and the different testing modalities and strategies. Discussion ATLAS is the first comprehensive study on HIV self-testing in West Africa. The ATLAS programme focuses particularly on the secondary distribution of HIVST. This protocol was approved by three national ethic committees and the WHO’s Ethical Research Committee.
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- 2021
44. Accuracy of self-reported HIV testing history and awareness of HIV-positive status among people living with HIV in four Sub-Saharan African countries
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Xia, Y, Milwid, R, Godin, A, Boily, M-C, Johnson, L, Marsh, K, Eaton, J, and Maheu-Giroux, M
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virus diseases - Abstract
Background: In many countries in Sub-Saharan Africa, self-reported HIV testing history and awareness of HIV-positive status from household surveys are used to estimate the percentage of people living with HIV (PLHIV) who know their HIV status. Despite widespread use, there is limited empirical information on the sensitivity of those self-reports, which can be affected by non-disclosure. Methods: Bayesian latent class models were used to estimate the sensitivity of self-reported HIV testing history and awareness of HIV-positive status in four Population-based HIV Impact Assessment surveys in Eswatini, Malawi, Tanzania, and Zambia. Antiretroviral (ARV) metabolites biomarkers were used to identify persons on treatment who did not accurately report their status. For those without ARV biomarkers, the pooled estimate of non-disclosure among untreated persons was 1.48 higher than those on treatment. Results: Among PLHIV, the sensitivity of self-reported HIV testing history ranged 96% to 99% across surveys. Sensitivity of self-reported awareness of HIV status varied from 91% to 97%. Non-disclosure was generally higher among men and those aged 15-24 years. Adjustments for imperfect sensitivity did not substantially influence estimates of of PLHIV ever tested (difference
- Published
- 2020
45. Prevalence and correlates of anal intercourse among female sex workers in eSwatini (vol 15, e0228849, 2020)
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Owen, BN, Maheu-Giroux, M, Matse, S, Mnisi, Z, Baral, S, Ketende, SC, Baggaley, RF, and Boily, M-C
- Published
- 2020
46. Complementation of the pina (null) allele with the wild type Pina sequence restores a soft phenotype in transgenic wheat
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Martin, J. M., Meyer, F. D., Smidansky, E. D., Wanjugi, H., Blechl, A. E., and Giroux, M. J.
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- 2006
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47. Wheat puroindolines interact to form friabilin and control wheat grain hardness
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Hogg, A. C., Sripo, T., Beecher, B., Martin, J. M., and Giroux, M. J.
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- 2004
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48. Puroindoline A-gene expression is involved in association of puroindolines to starch
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Capparelli, R., Borriello, G., Giroux, M. J., and Amoroso, M. G.
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- 2003
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49. Effect of multiple copies of puroindoline genes on grain softness
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See, D.R., Giroux, M., and Gill, B.S.
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Wheat -- Research ,Agricultural industry ,Business ,Research - Abstract
End use quality in wheat (Triticum aestivum L.) is primarily determined by grain hardness or texture. The puroindoline genes Pina and Pinb are the main components of the 15-kDa friabilin protein, which is associated with kernel softness. Pina and Pinb are expressed in diploid wheat species but are silent in tetraploid wheat. The active puroindolines in hexaploid, or bread wheat, were derived from Aegilops tauschii Coss., the D genome diploid donor. The focus of this study was to incorporate active puroindoline genes into fine A and B genomes of bread wheat and analyze their impact upon grain softness. Functional copies of Pina and Pinb in disomic substitution lines of T. monococcum L. chromosome 5[A.sup.m] for 5A of T. aestivum and 5[S.sup.s] of Aegilops searsii Feldman & Kislev ex K. Hammer for 5B of T. aestivum were used to produce lines that contained four copies (5[A.sup.m], 5D; 5[S.sup.s], 5D) and six copies (5[A.sup.m], 5[S.sup.s], 5D) of the puroindolines. There was a direct correlation in grain softness with the increase in copy number of the puroindolines. Northern blots showed increased expression of both Pina and Pinb. Extraction of TX114 soluble proteins indicated that levels of both proteins were also increased. Single kernel characterization system (SKCS) analysis showed a decrease in kernel hardness by approximately 10 points below the value of 71 for 'Chinese Spring' (CS) for each additional copy of Pina and Pinb added. These results indicate that increasing the functional copy number of the puroindolines can impact grain softness in bread wheat., WHEAT IS A STAPLE FOOD for half of the world's population. One of the defining characteristics for milling and baking of wheat is the kernel texture. The manifestation of kernel [...]
- Published
- 2004
50. Expression of wild-type pinB sequence in transgenic wheat complements a hard phenotype
- Author
-
Beecher, B., Bettge, A., Smidansky, E., and Giroux, M.
- Published
- 2002
- Full Text
- View/download PDF
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