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1. Biliary atresia is associated with polygenic susceptibility in ciliogenesis and planar polarity effector genes

Author

Glessner, Joseph T, Ningappa, Mylarappa B, Ngo, Kim A, Zahid, Maliha, So, Juhoon, Higgs, Brandon W, Sleiman, Patrick MA, Narayanan, Tejaswini, Ranganathan, Sarangarajan, March, Michael, Prasadan, Krishna, Vaccaro, Courtney, Reyes-Mugica, Miguel, Velazquez, Jeremy, Salgado, Claudia M, Ebrahimkhani, Mo R, Schmitt, Lori, Rajasundaram, Dhivyaa, Paul, Morgan, Pellegrino, Renata, Gittes, George K, Li, Dong, Wang, Xiang, Billings, Jonathan, Squires, Robert, Ashokkumar, Chethan, Sharif, Khalid, Kelly, Deirdre, Dhawan, Anil, Horslen, Simon, Lo, Cecilia W, Shin, Donghun, Subramaniam, Shankar, Hakonarson, Hakon, and Sindhi, Rakesh

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Genetics, Digestive Diseases, Human Genome, Congenital Structural Anomalies, Prevention, Liver Disease, Infant Mortality, Pediatric, Rare Diseases, Perinatal Period - Conditions Originating in Perinatal Period, Chronic Liver Disease and Cirrhosis, Aetiology, 2.1 Biological and endogenous factors, Child, Animals, Mice, Humans, Biliary Atresia, Genome-Wide Association Study, Genetic Predisposition to Disease, Zebrafish, Canada, Ciliogenesis, Polygenic Susceptibility, Portal Vein, Tube Morphogenesis, Vascular Development, Public Health and Health Services, Gastroenterology & Hepatology, Clinical sciences
Abstract

Background & aimsBiliary atresia (BA) is poorly understood and leads to liver transplantation (LT), with the requirement for and associated risks of lifelong immunosuppression, in most children. We performed a genome-wide association study (GWAS) to determine the genetic basis of BA.MethodsWe performed a GWAS in 811 European BA cases treated with LT in US, Canadian and UK centers, and 4,654 genetically matched controls. Whole-genome sequencing of 100 cases evaluated synthetic association with rare variants. Functional studies included whole liver transcriptome analysis of 64 BA cases and perturbations in experimental models.ResultsA GWAS of common single nucleotide polymorphisms (SNPs), i.e. allele frequencies >1%, identified intronic SNPs rs6446628 in AFAP1 with genome-wide significance (p = 3.93E-8) and rs34599046 in TUSC3 at sub-threshold genome-wide significance (p = 1.34E-7), both supported by credible peaks of neighboring SNPs. Like other previously reported BA-associated genes, AFAP1 and TUSC3 are ciliogenesis and planar polarity effectors (CPLANE). In gene-set-based GWAS, BA was associated with 6,005 SNPs in 102 CPLANE genes (p = 5.84E-15). Compared with non-CPLANE genes, more CPLANE genes harbored rare variants (allele frequency

Published
2023

4. A neurodevelopmental epigenetic programme mediated by SMARCD3–DAB1–Reelin signalling is hijacked to promote medulloblastoma metastasis

Author

Zou, Han, Poore, Bradley, Brown, Emily E., Qian, Jieqi, Xie, Bin, Asimakidou, Evridiki, Razskazovskiy, Vladislav, Ayrapetian, Deanna, Sharma, Vaibhav, Xia, Shunjin, Liu, Fei, Chen, Apeng, Guan, Yongchang, Li, Zhengwei, Wanggou, Siyi, Saulnier, Olivier, Ly, Michelle, Fellows-Mayle, Wendy, Xi, Guifa, Tomita, Tadanori, Resnick, Adam C., Mack, Stephen C., Raabe, Eric H., Eberhart, Charles G., Sun, Dandan, Stronach, Beth E., Agnihotri, Sameer, Kohanbash, Gary, Lu, Songjian, Herrup, Karl, Rich, Jeremy N., Gittes, George K., Broniscer, Alberto, Hu, Zhongliang, Li, Xuejun, Pollack, Ian F., Friedlander, Robert M., Hainer, Sarah J., Taylor, Michael D., and Hu, Baoli

Published
2023
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11. Chitinase-3-like 1 protein complexes modulate macrophage-mediated immune suppression in glioblastoma

Author

Chen, Apeng, Jiang, Yinan, Li, Zhengwei, Wu, Lingxiang, Santiago, Ulises, Zou, Han, Cai, Chunhui, Sharma, Vaibhav, Guan, Yongchang, McCarl, Lauren H., Ma, Jie, Wu, Yijen L., Michel, Joshua, Shi, Yi, Konnikova, Liza, Amankulor, Nduka M., Zinn, Pascal O., Kohanbash, Gary, Agnihotri, Sameer, Lu, Songjian, Lu, Xinghua, Sun, Dandan, Gittes, George K., Wang, Qianghu, Xiao, Xiangwei, Yimlamai, Dean, Pollack, Ian F., Camacho, Carlos J., and Hu, Baoli

Subjects
Glycoproteins -- Genetic aspects -- Health aspects, Brain tumors -- Care and treatment -- Genetic aspects, Glioblastoma multiforme -- Care and treatment -- Genetic aspects, Cellular signal transduction -- Genetic aspects -- Health aspects, Macrophages -- Health aspects -- Genetic aspects, Immunosuppression -- Methods, Health care industry
Abstract

Glioblastoma is a highly malignant and incurable brain tumor characterized by intrinsic and adaptive resistance to immunotherapies. However, how glioma cells induce tumor immunosuppression and escape immunosurveillance remains poorly understood. Here, we find upregulation of cancer-intrinsic chitinase-3-like 1 (CHI3L1) signaling modulating an immunosuppressive microenvironment by reprogramming tumor-associated macrophages (TAMs). Mechanistically, CHI3L1 binding with galectin 3 (Gal3) selectively promotes TAM migration and infiltration with a protumor M2-like, but not an antitumor M1-like, phenotype in vitro and in vivo, governed by a transcriptional program of NF-[kappa]B/CEBP[beta] in the CHI3L1/Gal3-PI3K/AKT/mTOR axis. Conversely, galectin 3-binding protein (Gal3BP) negatively regulates this process by competing with Gal3 to bind CHI3L1. Administration of a Gal3BP mimetic peptide in syngeneic glioblastoma mouse models reverses immune suppression and attenuates tumor progression. These results shed light on the role of CHI3L1 protein complexes in immune evasion by glioblastoma and as a potential immunotherapeutic target for this devastating disease., Introduction Glioblastoma (GBM), the most common and lethal primary brain tumor, with a median survival rate of only 15 months, remains incurable despite intensive multimodal treatment of surgical resection, radio-chemotherapy, [...]

Published
2021
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13. Contributors

Author

Abbas, Abbas E., primary, Adams, David B., additional, Aggarwal, Piyush, additional, Ahmed, Bestoun H., additional, Albanese, Craig, additional, Albert, Matthew R., additional, Ali, Abubaker, additional, Alicuben, Evan, additional, Allaix, Marco E., additional, Altman, Ashley, additional, Ando, Hisami, additional, Andolfi, Ciro, additional, Annamalai, Alagappan, additional, Asare, Elliot A., additional, Asti, Emanuele, additional, Auchincloss, Hugh G., additional, Babic, Benjamin, additional, Baker, Talia B., additional, Ball, Chad G., additional, Barbetta, Arianna, additional, Barlow, John M., additional, Barr, Justin, additional, Barreto, Juan Camilo, additional, Barry, Linda, additional, Beal, Eliza W., additional, Beard, Kristin Wilson, additional, Beck, David E., additional, Behrns, Kevin E., additional, Bellevue, Oliver C., additional, Bellorin-Marin, Omar E., additional, Bergman, Jacques, additional, Berry, James, additional, Besselink, Marc G.H., additional, Bharucha, Adil E., additional, Bilchik, Anton J., additional, Bildzukewicz, Nikolai A., additional, Bingham, Jason, additional, Birnbaum, Elisa, additional, Black, Sylvester M., additional, Blackmon, Shanda H., additional, Bleier, Joshua I.S., additional, Bodzin, Adam S., additional, Boland, C. Richard, additional, Bolton, John, additional, Bolton, Nathan, additional, Bonavina, Luigi, additional, Bonds, Morgan, additional, Bouwense, Stefan A.W., additional, Boys, Joshua A., additional, Bravo-Infante, Raquel, additional, Bremner, Ross M., additional, Brenner, Bruce M., additional, Brown, Shaun R., additional, Callery, Mark P., additional, Cameron, John L., additional, Camilleri, Michael, additional, Campbell, Jacob, additional, Cassim, Riaz, additional, Castillo-Angeles, Manuel, additional, Cauley, Christy, additional, Cavaness, Keith M., additional, Cerfolio, Robert J., additional, Champagne, Bradley J., additional, Chandrasoma, Parakrama, additional, Chang, Alex L., additional, Chapman, Christopher G., additional, Chapman, William C., additional, Cheek, Susannah, additional, Chen, Harvey S., additional, Cho, Clifford S., additional, Choi, Eric T., additional, Choi, Eugene A., additional, Chojnacki, Karen A., additional, Choti, Michael A., additional, Christie, Ian, additional, Chua, Heidi, additional, Church, James M., additional, Cioffi, Jessica L., additional, Clark, Susannah, additional, Clavien, Pierre-Alain, additional, Cloud, Adam, additional, Colavita, Paul D., additional, Colquhoun, Steven D., additional, Conway, William, additional, Cools-Lartigue, Jonathan, additional, Coosemans, Willy, additional, Cornwell, Edward E., additional, Costantini, Mario, additional, Coyle, Yvonne, additional, Craig, Daniel A., additional, Croome, Kristopher P., additional, Cullen, Joseph J., additional, D'Andrea, Anthony P., additional, Dassopoulos, Themistocles, additional, Davila, Marta L., additional, Davila, Raquel E., additional, DeMeester, Steven R., additional, DeMeester, Tom R., additional, Dempsey, Daniel T., additional, dePrisco, Gregory, additional, Depypere, Lieven, additional, Dietz, David W., additional, Dillhoff, Mary E., additional, DiNorcia, Joseph, additional, Doane, Stephen M., additional, Dogeas, Epameinondas, additional, Dozois, Eric J., additional, Dumon, Kristoffel, additional, Dunn, Stephen P., additional, Dunst, Christy M., additional, Dussel, John N., additional, Dyer, Matthew, additional, Efron, Jonathan, additional, El-Gohary, Yousef, additional, Lakis, Mustapha El, additional, Ellison, E. Christopher, additional, Ellsmere, James, additional, Essani, Rahila, additional, Evans, Douglas B., additional, Fang, Sandy H., additional, Fasen, Geoffrey, additional, Fernando, Hiran C., additional, Ferri, Lorenzo, additional, Fichera, Alessandro, additional, Finck, Christine, additional, Fisher, Oliver M., additional, Fleshman, James W., additional, Fong, Yuman, additional, Foreman, Michael L., additional, Francone, Todd D., additional, Franko, Edward R., additional, French, Daniel, additional, Fuchs, Hans Friedrich, additional, Fuchs, Karl Hermann, additional, Funaki, Brian, additional, Funk, Geoffrey A., additional, Fusco, Joseph, additional, Gaitonde, Shrawan G., additional, Gajjar, Aakash H., additional, Garcia-Aguilar, Julio, additional, Gearhart, Susan, additional, Geller, David A., additional, Ghobadi, Comeron, additional, Gilbert, Sebastien, additional, Giles, David, additional, Gillaspie, Erin, additional, Girotti, Micah, additional, Gittes, George K., additional, Goodman, Michael D., additional, Gooszen, Hein G., additional, Gores, Gregory J., additional, Griffin, James F., additional, Griffin, S. Michael, additional, Grimm, Leander, additional, Grochola, L.F., additional, Habib, Fahim, additional, Hanks, John B., additional, Harris, James E., additional, Hartwig, Matthew G., additional, Hassan, Imran, additional, Hedrick, Traci L., additional, Hicks, Terry C., additional, Hodin, Richard, additional, Hofstetter, Wayne L., additional, Hogg, Melissa, additional, Hu, Yue-Yung, additional, Hungness, Eric S., additional, Hunt, Steven R., additional, Huseynova, Khumara, additional, Hyman, Neil H., additional, Iannitti, David A., additional, Indes, Jeffrey, additional, Jenkins, Megan, additional, Jensen, Todd, additional, Jeziorczak, Paul M., additional, Jilani, Danial, additional, Jiménez-Toscano, Marta, additional, Jobe, Blair A., additional, Johnston, Lily E., additional, Kahrilas, Peter J., additional, Kalady, Matthew F., additional, Kassira, Noor, additional, Katkhouda, Namir, additional, Katz, Philip O., additional, Keller, Deborah S., additional, Kelley, Matthew P., additional, Kennedy, Gregory D., additional, Kent, Tara Sotsky, additional, Kia, Leila, additional, Kibbe, Melina R., additional, Kim, John, additional, King, Alice, additional, Kiran, Ravi P., additional, Kirton, Orlando C., additional, Klein, Andrew, additional, Klein, Eric N., additional, Kohn, Geoffrey P., additional, Kovell, Robert Caleb, additional, Kozol, Robert, additional, Lacy, Antonio M., additional, Ladner, Daniela P., additional, Lagarde, S.M., additional, Laituri, Carrie A., additional, Landmann, Alessandra, additional, Lee, Janet T., additional, Lee, Lawrence L., additional, Leinicke, Jennifer A., additional, Lerut, Toni, additional, Levi, David M., additional, Li, Chao, additional, Liang, Yu, additional, Lichliter, Andrew H., additional, Lichliter, Warren E., additional, Lightner, Amy L., additional, Lile, Deacon J., additional, Lillemoe, Keith D., additional, Lin, Jules, additional, Lin, Shu S., additional, Lipham, John C., additional, Litle, Virginia R., additional, Lodhia, Nayna A., additional, Longo, Walter E., additional, Lord, Reginald V.N., additional, Louie, Brian E., additional, Low, Donald E., additional, Lowe, Val J., additional, Luc, Jessica G.Y., additional, Luketich, James D., additional, Ma, Yanling, additional, MacCarty, Robert L., additional, MacDonald, Blair, additional, Madoff, Robert D., additional, Magge, Deepa, additional, Maheshwari, Anurag, additional, Mahmoud, Najjia N., additional, Mahvi, David A., additional, Mahvi, David M., additional, Mak, Grace Z., additional, Mansfield, Sara A., additional, Manzano, Maricarmen, additional, Maron, David J., additional, Mathew, Melvy S., additional, Mathis, Kellie L., additional, Matthews, Jeffrey B., additional, McFadden, David W., additional, Merchea, Amit, additional, Messaris, Evangelos, additional, Miller, Daniel L., additional, Miller, Heidi J., additional, Millis, J. Michael, additional, Mittal, Sumeet K., additional, Molena, Daniela, additional, Montgomery, Stephanie C., additional, Moore, Ryan, additional, Morgan, Katherine A., additional, Mortenson, Melinda M., additional, Mulholland, Michael W., additional, Mulvihill, Michael S., additional, Mutch, Matthew, additional, Nafteux, Philippe Robert, additional, Nagaraju, Arun, additional, Nagorney, David M., additional, Nathan, Hari, additional, Natoli, Karen R., additional, Navuluri, Rakesh, additional, Nissen, Nicholas N., additional, Nobel, Tamar B., additional, Noordman, B.J., additional, Norton, Jeffrey A., additional, Novitsky, Yuri W., additional, Nussbaum, Michael S., additional, Nyberg, Scott L., additional, Oelschlager, Brant K., additional, Oh, Daniel S., additional, Otero-Piñeiro, Ana, additional, Oto, Aytekin, additional, Pachter, H. Leon, additional, Paidas, Charles N., additional, Palazzo, Francesco, additional, Paniccia, Alessandro, additional, Papaconstantinou, Harry T., additional, Pappas, Theodore N., additional, Pappou, Emmanouil P., additional, Parikh, Manish, additional, Paruch, Jennifer L., additional, Patel, Asish D., additional, Patel, Mikin, additional, Patti, Marco G., additional, Paulson, Emily Carter, additional, Pawlik, Timothy M., additional, Payne, Isaac, additional, Pemberton, John H., additional, Pendola, Michael, additional, Perez, Alexander, additional, Pernar, Luise I.M., additional, Peters, Walter R., additional, Petrowsky, Henrik, additional, Peyre, Christian G., additional, Phillips, Alexander W., additional, Pillai, Lashmikumar, additional, Plummer, Joseph M., additional, Pointer, David T., additional, Poruk, Katherine E., additional, Posner, Mitchell C., additional, Postier, Russell, additional, Prachand, Vivek N., additional, Pritts, Timothy A., additional, Quatrino, Gregory, additional, Ranka, Sagar, additional, Rattner, David W., additional, Reavis, Kevin M., additional, Reddy, Vikram B., additional, Remzi, Feza H., additional, Ricciardi, Rocco, additional, Rice, Thomas W., additional, Richman, Aaron, additional, Rider, Paul, additional, Roberts, John Paul, additional, Roberts, Patricia L., additional, Roggin, Kevin K., additional, Roll, Garrett Richard, additional, Rona, Kais, additional, Rosen, Charles B., additional, Ross, Samuel Wade, additional, Roth, J. Scott, additional, Rushing, Amy P., additional, Safar, Bashar, additional, Saldinger, Pierre F., additional, Samakar, Kamran, additional, Sandhu, Kulmeet K., additional, Schaheen, Lara W., additional, Schirmer, Bruce, additional, Schneider, Andrew, additional, Schulick, Richard D., additional, Schwab, Ben, additional, Scurci, Stephanie, additional, Senagore, Anthony, additional, Shah, Adil A., additional, Shah, Shimul A., additional, Shames, Brian, additional, Shanmugan, Skandan, additional, Shapiro, David S., additional, Silviera, Matthew, additional, Slakey, Douglas P., additional, Sloan, Joshua, additional, Smallwood, Nathan, additional, Smith, Shane P., additional, Smithers, B. Mark, additional, Smoot, Rory L., additional, Soares, Kevin C., additional, Soffer, Edy, additional, Solomina, Julia, additional, Soper, Nathaniel J., additional, Spechler, Stuart Jon, additional, Sridhar, Praveen, additional, Steele, Scott R., additional, Sternbach, Joel M., additional, Stevenson, Christina E., additional, Strong, Scott A., additional, Sucandy, Iswanto, additional, Sundaram, Magesh, additional, Sundaresan, Sudhir, additional, Swanstrom, Lee L., additional, Sylla, Patricia, additional, Takada, Tadahiro, additional, Talbot, Ethan, additional, Tam, Vernissia, additional, Tamm, Eric P., additional, Tatarian, Talar, additional, Tavakkoli, Ali, additional, Te, Helen S., additional, Teitelbaum, Ezra N., additional, Ternent, Charles A., additional, Thompson, Jon S., additional, Thomson, Iain, additional, Thorson, Alan G., additional, Thorson, Chad M., additional, Totten, Crystal F., additional, Truty, Mark J., additional, Tsai, Susan, additional, Tseng, Jennifer, additional, Tullius, Tom, additional, Tzakis, Andreas G., additional, van Lanschot, J.J.B., additional, van Santvoort, Hjalmar C., additional, Van Veer, Hans, additional, Vega, Jorge A., additional, Velanovich, Vic, additional, Vogler, Sarah A., additional, Wang, Huamin, additional, Ward, Mark A., additional, Warner, Brad W., additional, Warner, Susanne G., additional, Watson, Thomas J., additional, Waxman, Irving, additional, Webster-Lake, Carissa, additional, Wei, Benjamin, additional, Weiser, Martin R., additional, Wells, Dennis, additional, Wells, Katerina, additional, Welton, Mark Lane, additional, Wen, Yuxiang, additional, Wendling, Mark R., additional, Wesson, Hadley K.H., additional, Wexner, Steven D., additional, White, Rebekah R., additional, Whitlow, Charles B., additional, Wijnhoven, B.P.L., additional, Wilkes, Justin, additional, Wilson, Rickesha L., additional, Witkowski, Piotr, additional, Wolfgang, Christopher L., additional, Worrell, Stephanie G., additional, Yang, Jian, additional, Yeo, Charles J., additional, Yeung, Ching, additional, Yung, Evan E., additional, Zafar, Syed Nabeel, additional, Zaninotto, Giovanni, additional, Zeh, Herbert, additional, Zehetner, Joerg, additional, Zenilman, Michael E., additional, Zimmerman, Pamela, additional, and Zuccaro, Gregory, additional

Published
2019
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15. Loss of mTORCI signaling alters pancreatic [alpha] cell mass and impairs glucagon secretion

Author

Bozadjieva, Nadejda, Blandino-Rosano, Manuel, Chase, Jennifer, Dai, Xiao-Qing, Cummings, Kelsey, Gimeno, Jennifer, Dean, Danielle, Powers, Alvin C., Gittes, George K., Ruegg, Markus A., Hall, Michael N., MacDonald, Patrick E., and Bernal-Mizrachi, Ernesto

Subjects
Glucagon -- Research, Homeostasis -- Research, Hyperglycemia -- Development and progression, Health care industry
Abstract

Glucagon plays a major role in the regulation of glucose homeostasis during fed and fasting states. However, the mechanisms responsible for the regulation of pancreatic [alpha] cell mass and function are not completely understood. In the current study, we identified mTOR complex 1 (mTORC1) as a major regulator of [alpha] cell mass and glucagon secretion. Using mice with tissuespecific deletion of the mTORC1 regulator Raptor in [alpha] cells ([[alpha]Raptor.sup.KO]), we showed that mTORC1 signaling is dispensable for [alpha] cell development, but essential for [alpha] cell maturation during the transition from a milk-based diet to a chow-based diet after weaning. Moreover, inhibition of mTORC1 signaling in [[alpha]Raptor.sup.KO] mice and in WT animals exposed to chronic rapamycin administration decreased glucagon content and glucagon secretion. In [[alpha]Raptor.sup.KO] mice, impaired glucagon secretion occurred in response to different secretagogues and was mediated by alterations in [K.sub.ATP] channel subunit expression and activity. Additionally, our data identify the mTORC1/FoxA2 axis as a link between mTORC1 and transcriptional regulation of key genes responsible for [alpha] cell function. Thus, our results reveal a potential function of mTORC1 in nutrient-dependent regulation of glucagon secretion and identify a role for mTORC1 in controlling [alpha] cell-mass maintenance., Introduction Type 1 (T1D) and type 2 diabetes (T2D) are characterized by uncontrolled hyperglycemia associated with the progressive decrease in insulin. Glucagon, insulin's counterregulatory hormone, plays a major role in [...]

Published
2017
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17. Figure S2 from Prolactin Promotes Fibrosis and Pancreatic Cancer Progression

Author

Tandon, Manuj, primary, Coudriet, Gina M., primary, Criscimanna, Angela, primary, Socorro, Mairobys, primary, Eliliwi, Mouhanned, primary, Singhi, Aatur D., primary, Cruz-Monserrate, Zobeida, primary, Bailey, Peter, primary, Lotze, Michael T., primary, Zeh, Herbert, primary, Hu, Jing, primary, Goffin, Vincent, primary, Gittes, George K., primary, Biankin, Andrew V., primary, and Esni, Farzad, primary

Published
2023
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18. Data from Prolactin Promotes Fibrosis and Pancreatic Cancer Progression

Author

Tandon, Manuj, primary, Coudriet, Gina M., primary, Criscimanna, Angela, primary, Socorro, Mairobys, primary, Eliliwi, Mouhanned, primary, Singhi, Aatur D., primary, Cruz-Monserrate, Zobeida, primary, Bailey, Peter, primary, Lotze, Michael T., primary, Zeh, Herbert, primary, Hu, Jing, primary, Goffin, Vincent, primary, Gittes, George K., primary, Biankin, Andrew V., primary, and Esni, Farzad, primary

Published
2023
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19. Supplementary Information from Prolactin Promotes Fibrosis and Pancreatic Cancer Progression

Author

Tandon, Manuj, primary, Coudriet, Gina M., primary, Criscimanna, Angela, primary, Socorro, Mairobys, primary, Eliliwi, Mouhanned, primary, Singhi, Aatur D., primary, Cruz-Monserrate, Zobeida, primary, Bailey, Peter, primary, Lotze, Michael T., primary, Zeh, Herbert, primary, Hu, Jing, primary, Goffin, Vincent, primary, Gittes, George K., primary, Biankin, Andrew V., primary, and Esni, Farzad, primary

Published
2023
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29. Chemical pancreatectomy treats chronic pancreatitis while preserving endocrine function in preclinical models

Author

Saleh, Mohamed, Sharma, Kartikeya, Kalsi, Ranjeet, Fusco, Joseph, Sehrawat, Anuradha, Saloman, Jami L., Guo, Ping, Zhang, Ting, Mohamed, Nada, Wang, Yan, Prasadan, Krishna, and Gittes, George K.

Subjects
Pancreatectomy -- Methods, Pancreatitis -- Care and treatment, Acetic acid -- Usage, Health care industry
Abstract

Chronic pancreatitis affects over 250,000 people in the US and millions worldwide. It is associated with chronic debilitating pain, pancreatic exocrine failure, and high risk of pancreatic cancer and usually progresses to diabetes. Treatment options are limited and ineffective. We developed a new potential therapy, wherein a pancreatic ductal infusion of 1%-2% acetic acid in mice and nonhuman primates resulted in a nonregenerative, near-complete ablation of the exocrine pancreas, with complete preservation of the islets. Pancreatic ductal infusion of acetic acid in a mouse model of chronic pancreatitis led to resolution of chronic inflammation and pancreatitis-associated pain. Furthermore, acetic acid-treated animals showed improved glucose tolerance and insulin secretion. The loss of exocrine tissue in this procedure would not typically require further management in patients with chronic pancreatitis because they usually have pancreatic exocrine failure requiring dietary enzyme supplements. Thus, this procedure, which should be readily translatable to humans through an endoscopic retrograde cholangiopancreatography (ERCP), may offer a potential innovative nonsurgical therapy for chronic pancreatitis that relieves pain and prevents the progression of pancreatic diabetes., Introduction Chronic pancreatitis (CP) affects approximately 250,000 people in the US and millions worldwide (1-4), and the incidence is increasing with the increase in alcohol abuse (5). Also, cystic fibrosis [...]

Published
2021
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30. Ionizable lipid nanoparticles deliver mRNA to pancreatic β cells via macrophage-mediated gene transfer

Author

Melamed, Jilian R., primary, Yerneni, Saigopalakrishna S., additional, Arral, Mariah L., additional, LoPresti, Samuel T., additional, Chaudhary, Namit, additional, Sehrawat, Anuradha, additional, Muramatsu, Hiromi, additional, Alameh, Mohamad-Gabriel, additional, Pardi, Norbert, additional, Weissman, Drew, additional, Gittes, George K., additional, and Whitehead, Kathryn A., additional

Published
2023
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38. Contributors

Author

Abou-Alfa, Ghassan K., primary, Abou Khalil, Jad, additional, Addeo, Pietro, additional, Adsay, N. Volkan, additional, Agarwal, Anil Kumar, additional, Alemi, Farzad, additional, Allen, Peter J., additional, Al-Mukhtar, Ahmed, additional, Aloia, Thomas A., additional, Andersen, Jesper B., additional, Anderson, Christopher D., additional, Arslan-Carlon, Vittoria, additional, Asbun, Horacio J., additional, Aussilhou, Béatrice, additional, Awad, Joseph, additional, Azoulay, Daniel, additional, Bachellier, Philippe, additional, Baker, Talia B., additional, Bamboat, Zubin M., additional, Barkun, Jeffrey Stewart, additional, Bassi, Claudio, additional, Basturk, Olca, additional, Beard, Rachel E., additional, Bedossa, Pierre, additional, Belghiti, Jacques, additional, Bellorin-Marin, Omar, additional, Besselink, Marc G.H., additional, Bilchik, Anton J., additional, Blumgart, Leslie H., additional, Boas, Franz Edward, additional, Brody, Lynn A., additional, Brown, Karen T., additional, Bruix, Jordi, additional, Bruno, David A., additional, Brunt, Elizabeth M., additional, Burns, Justin M., additional, Butturini, Giovanni, additional, Caicedo, Juan Carlos, additional, Callery, Mark P., additional, Calvino, Abdul Saied, additional, Carpenter, Danielle H., additional, Carter, C. Ross, additional, Cauchy, François, additional, Chan, Chung Yip, additional, Chan, See Ching, additional, Chapman, William C., additional, Cherqui, Daniel, additional, Cho, Clifford S., additional, Chung, Jin Wook, additional, Clanton, Jesse, additional, Clary, Bryan Marshall, additional, Cleary, Sean Patrick, additional, Collins, Kelly M., additional, Conneely, John Barry, additional, Connell, Louise C., additional, Corvera, Carlos U., additional, Costa, Guido, additional, Covey, Anne M., additional, Crippin, Jeffrey S., additional, Croome, Kristopher P., additional, Dabbous, Hany, additional, D'Angelica, Michael I., additional, Darcy, Michael D., additional, Davis, Jeremy L., additional, de Jonge, Jeroen, additional, DeMatteo, Ronald P., additional, DePeralta, Danielle K., additional, Desai, Niraj M., additional, de Santibañes, Eduardo, additional, de Santibañes, Martin, additional, Dickson, Euan J., additional, DiMaio, Christopher John, additional, Do, Richard Kinh Gian, additional, Dokmak, Safi, additional, Donati, Marcello, additional, Doyle, M.B. Majella, additional, Dudeja, Vikas, additional, Dunphy, Mark, additional, Earl, Truman M., additional, Ebata, Tomoki, additional, Dika, Imane El, additional, El-Gohary, Yousef, additional, Endo, Itaru, additional, Enestvedt, C. Kristian, additional, Espat, N. Joseph, additional, Ethun, Cecilia G., additional, Fan, Sheung Tat, additional, Fanta, Paul T., additional, Farges, Olivier, additional, Ferrone, Cristina R., additional, Fields, Ryan C., additional, Fischer, Mary, additional, Fisher, Sarah B., additional, Flaherty, Devin C., additional, Fong, Yuman, additional, Friedman, Scott L., additional, Gabr, Ahmed, additional, Galloway, John R., additional, Geller, David A., additional, Gerdes, Hans, additional, Gerst, Scott R., additional, Gittes, George K., additional, Glorioso, Jaime, additional, Gluskin, Jill S., additional, Goh, Brian K.P., additional, Gonzalez, Stevan A., additional, Goodman, Karyn A., additional, Gores, Gregory J., additional, Gotuzzo, Eduardo H., additional, Gouma, Dirk J., additional, Greig, Paul D., additional, Griffin, James F., additional, Halloran, Christopher M., additional, Halpern, Neil A., additional, Hammill, Chet W., additional, Hansen, Paul D., additional, Harding, James J., additional, M. Harrison, Ewen, additional, Hartwig, Werner, additional, Hasegawa, Kiyoshi, additional, Hechtman, Jaclyn F., additional, Heimbach, Julie K., additional, Helton, William S., additional, Hemming, Alan W., additional, Henderson, J. Michael, additional, Hirshberg, Asher, additional, Howe, James R., additional, Hughes, Christopher B., additional, Iacobuzio-Donahue, Christine, additional, Jarnagin, William R., additional, Jenkins, Roger L., additional, Jutric, Zeljka, additional, Kahlert, Christoph, additional, Kallini, Joseph Ralph, additional, Kangrga, Ivan, additional, Karanicolas, Paul J., additional, Katz, Seth S., additional, Katz, Steven C., additional, Kelly, Kaitlyn J., additional, Kemeny, Nancy E., additional, Kennedy, Eugene P., additional, Khalili, Korosh, additional, Khan, Adeel S., additional, Khan, Saboor, additional, Kim, Heung Bae, additional, Kingham, T. Peter, additional, Kirk, Allan D., additional, S. Klimstra, David, additional, Kluger, Michael, additional, Knechtle, Stuart J., additional, Koea, Jonathan B., additional, Kokudo, Norihiro, additional, Koliogiannis, Dionysios, additional, Kooby, David A., additional, Korenblat, Kevin, additional, Krebs, Simone, additional, LaQuaglia, Michael J., additional, LaQuaglia, Michael P., additional, LaRusso, Nicholas F., additional, Laurent, Alexis, additional, Lazaridis, Konstantinos N., additional, Leal, Julie N., additional, Lee, Eliza J., additional, Lee, Major Kenneth, additional, Lee, Ser Yee, additional, Lencioni, Riccardo, additional, Liccioni, Alexandre, additional, Lidsky, Michael E., additional, Lin, Chung-Wei, additional, Linehan, David C., additional, Lopez-Solis, Roberto Carlos, additional, Lowell, Jeffrey A., additional, Madoff, David C., additional, Maggi, Jason, additional, Maithel, Shishir K., additional, Majeed, Ali W., additional, Malfertheiner, Peter, additional, Malleo, Giuseppe, additional, Mao, Shennen A., additional, Marchegiani, Giovanni, additional, Marcos, Luis A., additional, Markmann, James F., additional, Marsh, J. Wallis, additional, Martin, Robert C.G., additional, Matsuyama, Ryusei, additional, Matter, Matthias S., additional, Mattera, Francisco Juan, additional, Maxwell, Jessica E., additional, Mazza, Oscar M., additional, McGilvray, Ian D., additional, McKay, Colin J., additional, McWeeney, Doireann M., additional, Melendez, Jose, additional, Mendelsohn, Robin B., additional, Miller, George, additional, Mönkemüller, Klaus E., additional, Mori, Ryutaro, additional, Moutinho, Vitor, additional, Nagino, Masato, additional, Nagorney, David M., additional, Nagula, Satish, additional, Nakeeb, Attila, additional, Nedredal, Geir I., additional, Neoptolemos, John P., additional, Neuberger, James, additional, Nyberg, Scott L., additional, O'Connor, Rachel, additional, O'Grady, John G., additional, Oldfield, Frances E., additional, Oldhafer, Karl J., additional, Olthoff, Kim M., additional, Orloff, Susan L., additional, Paniccia, Alessandro, additional, Paradis, Valérie, additional, Parks, Rowan W., additional, Pascal, Gérard, additional, Pastores, Stephen M., additional, Pawlik, Timothy M., additional, Pillarisetty, Venu G., additional, Pingpank, James Francis, additional, Pinson, C. Wright, additional, Pitt, Henry Anthony, additional, Pomposelli, James J., additional, Procopio, Fabio, additional, Pucci, Michael J., additional, Qadan, Motaz, additional, Rajkomar, Kheman, additional, Reddy, Srinevas K., additional, Reig, Maria E., additional, Reza, Joseph Arturo, additional, Roberts, John Paul, additional, Robson, Piera Marie Cote, additional, Rocha, Flavio G., additional, Roll, Garrett Richard, additional, Ronnekleiv-Kelly, Sean M., additional, Rosemurgy, Alexander S., additional, Rosen, Charles B., additional, Saldinger, Pierre F., additional, Salem, Riad, additional, Salem, Suhail Bakr, additional, Salvia, Roberto, additional, Sandroussi, Charbel, additional, Sanford, Dominic E., additional, Scatton, Olivier, additional, Schattner, Mark Andrew, additional, Schecter, William Palmer, additional, Schoellhammer, Hans Francis, additional, Schulick, Richard D., additional, Schwartz, Lawrence H., additional, Shah, Kevin N., additional, Shepherd, Ross W., additional, Shimada, Hiroshi, additional, Shimoda, Masafumi, additional, Shindoh, Junichi, additional, Shokouh-Amiri, Hosein, additional, Sicklick, Jason K., additional, Siegelbaum, Robert H., additional, Singh, Gagandeep, additional, Smoot, Rory L., additional, Solomon, Stephen B., additional, Soubrane, Olivier, additional, Spinelli, Nicholas, additional, Stauffer, John A., additional, Stewart, Lygia, additional, Strand, Matthew S., additional, Tabibian, James H., additional, Torzilli, Guido, additional, Trotter, James F., additional, Turcotte, Simon, additional, Turmelle, Yumirle P., additional, Tzimas, Demetrios J., additional, Van Gulik, Thomas, additional, Vannucci, Andrea, additional, Vauthey, Jean-Nicolas, additional, Vetter, Diana, additional, Vilgrain, Valérie, additional, Villamil, Alejandra Maria, additional, Voigt, Louis P., additional, Vollmer, Charles M., additional, Wands, Jack R., additional, Wattacheril, Julia, additional, Weber, Sharon Marie, additional, Weiss, Matthew J., additional, Weitz, Jürgen, additional, Werner, Jens, additional, Winner, Megan, additional, Wong, John, additional, Yang, Dennis, additional, Yarmohammadi, Hooman, additional, Yeo, Charles J., additional, Yeo, Theresa Pluth, additional, Yoon, Chang Jin, additional, Yopp, Adam, additional, Young, D. Owen, additional, Zhao, Kai, additional, Zibari, Gazi B., additional, and Zogopoulos, George, additional

Published
2017
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42. Polarized macrophages promote gestational beta cell growth through extracellular signal‐regulated kinase 5 signalling

Author

Jiang, Yinan, primary, Chen, Apeng, additional, Kline, Diana, additional, Liu, Qun, additional, Ma, Jie, additional, Wang, Yan, additional, Zhang, Ting, additional, Qian, Jieqi, additional, Nelson, Laura, additional, Prasadan, Krishna, additional, Hu, Baoli, additional, Gittes, George K., additional, and Xiao, Xiangwei, additional

Published
2022
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48. Hijacking a neurodevelopmental epigenomic program in metastatic dissemination of medulloblastoma

Author

Zou, Han, primary, Poore, Bradley, additional, Brown, Emily, additional, Qian, Jieqi, additional, Xie, Bin, additional, Asimakidou, Evridiki, additional, Razskazovskiy, Vladislav, additional, Ayrapetian, Deanna, additional, Sharma, Vaibhav, additional, Xia, Shunjin, additional, Liu, Fei, additional, Chen, Apeng, additional, Guan, Yongchang, additional, Li, Zhengwei, additional, Wanggou, Siyi, additional, Saulnier, Olivier, additional, Ly, Michelle, additional, Fellows-Mayle, Wendy, additional, Xi, Guifa, additional, Tomita, Tadanori, additional, Resnick, Adam, additional, Mack, Stephen, additional, Raabe, Eric, additional, Eberhart, Charles, additional, Sun, Dandan, additional, Stronach, Beth, additional, Agnihotri, Sameer, additional, Kohanbash, Gary, additional, Lu, Songjian, additional, Herrup, Karl, additional, Rich, Jeremy, additional, Gittes, George K., additional, Broniscer, Alberto, additional, Hu, Zhongliang, additional, Li, Xuejun, additional, Pollack, Ian, additional, Friedlander, Robert, additional, Hainer, Sarah, additional, Taylor, Michael, additional, and Hu, Baoli, additional

Published
2022
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