94 results on '"Giunchi, S."'
Search Results
2. EP446 When can we suspect gynecological lymphomas? Ultrasound features of ovarian and uterine lymphomas, a single-center experience
- Author
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Boussedra, S, primary, Giunchi, S, additional, Perrone, AM, additional, De Leo, A, additional, Tesei, M, additional, and De Iaco, P, additional
- Published
- 2019
- Full Text
- View/download PDF
3. Imaging of gynecological disease: clinical and ultrasound characteristics of uterine sarcomas
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Ludovisi, Manuela, Moro, Francesca, Pasciuto, Tina, Di Noi, Silvia, Giunchi, S, Savelli, L, Pascual, M A, Sladkevicius, P, Alcazar, J L, Franchi, D, Mancari, R, Moruzzi, M C, Jurkovic, D, Chiappa, V, Guerriero, S, Exacoustos, C, Epstein, E, Frühauf, P, Fischerova, D, Fruscio, R, Ciccarone, F, Zannoni, Gian Franco, Scambia, Giovanni, Valentin, L, and Testa, Antonia Carla
- Subjects
endometrial stromal ,leiomyosarcoma ,pattern recognition ,sarcoma ,ultrasonography ,Settore MED/40 - GINECOLOGIA E OSTETRICIA - Published
- 2019
4. Three-dimensional transvaginal sonography in local staging of cervical carcinoma: description of a novel technique and preliminary results
- Author
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GHI, T., GIUNCHI, S., KULEVA, M., SANTINI, D., SAVELLI, L., FORMELLI, G., CASADIO, P., COSTA, S., MERIGGIOLA, M. C., and PELUSI, G.
- Published
- 2007
5. Imaging in gynecological disease: clinical and ultrasound characteristics of endometrioid ovarian cancer
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Moro, F, Magoga, G, Pasciuto, T, Mascilini, F, Moruzzi, MC, Fischerova, D, Savelli, L, Giunchi, S, Mancari, R, Franchi, D, Czekierdowski, A, Froyman, Wouter, Verri, D, Epstein, E, Chiappa, V, Guerriero, S, Zannoni, GF, Timmerman, Dirk, Scambia, G, Valentin, L, and Testa, AC
- Subjects
endocrine system diseases ,female genital diseases and pregnancy complications - Abstract
To describe the clinical and ultrasound characteristics of ovarian pure endometrioid carcinoma. ispartof: Ultrasound in Obstetrics & Gynecology vol:52 issue:4 pages:535-543 ispartof: location:England status: published
- Published
- 2018
6. Imaging in gynecological disease (15): clinical and ultrasound characteristics of uterine sarcoma
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Ludovisi, M, Moro, F, Pasciuto, T, Di Noi, S, Giunchi, S, Savelli, L, Pascual, M, Sladkevicius, P, Alcazar, J, Franchi, D, Mancari, R, Moruzzi, M, Jurkovic, D, Chiappa, V, Guerriero, S, Exacoustos, C, Epstein, E, Frühauf, P, Fischerova, D, Fruscio, R, Ciccarone, F, Zannoni, G, Scambia, G, Valentin, L, Testa, A, Pascual, M A, Alcazar, J L, Moruzzi, M C, Zannoni, G F, Testa, A C, Ludovisi, M, Moro, F, Pasciuto, T, Di Noi, S, Giunchi, S, Savelli, L, Pascual, M, Sladkevicius, P, Alcazar, J, Franchi, D, Mancari, R, Moruzzi, M, Jurkovic, D, Chiappa, V, Guerriero, S, Exacoustos, C, Epstein, E, Frühauf, P, Fischerova, D, Fruscio, R, Ciccarone, F, Zannoni, G, Scambia, G, Valentin, L, Testa, A, Pascual, M A, Alcazar, J L, Moruzzi, M C, Zannoni, G F, and Testa, A C
- Abstract
Objective: To describe the clinical and ultrasound characteristics of uterine sarcomas. Methods: This was a retrospective multicenter study. From the databases of 13 ultrasound centers, we identified patients with a histological diagnosis of uterine sarcoma with available ultrasound reports and ultrasound images who had undergone preoperative ultrasound examination between 1996 and 2016. As the first step, each author collected information from the original ultrasound reports from his/her own center on predefined ultrasound features of the tumors and by reviewing the ultrasound images to identify information on variables not described in the original report. As the second step, 16 ultrasound examiners reviewed the images electronically in a consensus meeting and described them using predetermined terminology. Results: We identified 116 patients with leiomyosarcoma, 48 with endometrial stromal sarcoma and 31 with undifferentiated endometrial sarcoma. Median age of the patients was 56 years (range, 26–86 years). Most patients were symptomatic at diagnosis (164/183 (89.6%)), the most frequent presenting symptom being abnormal vaginal bleeding (91/183 (49.7%)). Patients with endometrial stromal sarcoma were younger than those with leiomyosarcoma and undifferentiated endometrial sarcoma (median age, 46 years vs 57 and 60 years, respectively). According to the assessment by the original ultrasound examiners, the median diameter of the largest tumor was 91 mm (range, 7–321 mm). Visible normal myometrium was reported in 149/195 (76.4%) cases, and 80.0% (156/195) of lesions were solitary. Most sarcomas (155/195 (79.5%)) were solid masses (> 80% solid tissue), and most manifested inhomogeneous echogenicity of the solid tissue (151/195 (77.4%)); one sarcoma was multilocular without solid components. Cystic areas were described in 87/195 (44.6%) tumors and most cyst cavities had irregular walls (67/87 (77.0%)). Internal shadowing was observed in 42/192 (21.9%) sarcomas and fan
- Published
- 2019
7. Ultrasound features of uterine leiomyosarcomas
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Ludovisi, M, Giunchi, S, Savelli, L, Franchi, D, Mancari, R, Di Noi, S, Pasciuto, T, Sladkevicius, P, Guerriero, S, Pascual, M, Alcazar, J, Jurkovic, D, Exacoustos, C, Chiappa, V, Epstein, E, Fruhauf, P, Fischerová, D, Fruscio, R, Zannoni, G, Scambia, G, Valentin, L, Testa, AC, Ludovisi, M, Giunchi, S, Savelli, L, Franchi, D, Mancari, R, Di Noi, S, Pasciuto, T, Sladkevicius, P, Guerriero, S, Pascual, M, Alcazar, J, Jurkovic, D, Exacoustos, C, Chiappa, V, Epstein, E, Fruhauf, P, Fischerová, D, Fruscio, R, Zannoni, G, Scambia, G, Valentin, L, and Testa, A
- Subjects
Uterine leiomyosarcoma - Published
- 2017
8. Imaging in gynecological disease (15): clinical and ultrasound characteristics of uterine sarcoma
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Ludovisi, M., primary, Moro, F., additional, Pasciuto, T., additional, Di Noi, S., additional, Giunchi, S., additional, Savelli, L., additional, Pascual, M. A., additional, Sladkevicius, P., additional, Alcazar, J. L., additional, Franchi, D., additional, Mancari, R., additional, Moruzzi, M. C., additional, Jurkovic, D., additional, Chiappa, V., additional, Guerriero, S., additional, Exacoustos, C., additional, Epstein, E., additional, Frühauf, F., additional, Fischerova, D., additional, Fruscio, R., additional, Ciccarone, F., additional, Zannoni, G. F., additional, Scambia, G., additional, Valentin, L., additional, and Testa, A. C., additional
- Published
- 2019
- Full Text
- View/download PDF
9. Imaging in gynecological disease (14): clinical and ultrasound characteristics of ovarian clear cell carcinoma
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Pozzati, F., primary, Moro, F., additional, Pasciuto, T., additional, Gallo, C., additional, Ciccarone, F., additional, Franchi, D., additional, Mancari, R., additional, Giunchi, S., additional, Timmerman, D., additional, Landolfo, C., additional, Epstein, E., additional, Chiappa, V., additional, Fischerova, D., additional, Fruscio, R., additional, Zannoni, G. F., additional, Valentin, L., additional, Scambia, G., additional, and Testa, A. C., additional
- Published
- 2018
- Full Text
- View/download PDF
10. Imaging in gynecological disease (14): clinical and ultrasound characteristics of ovarian clear cell carcinoma
- Author
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Pozzati, F, Moro, F, Pasciuto, T, Gallo, C, Ciccarone, F, Franchi, D, Mancari, R, Giunchi, S, Timmerman, D, Landolfo, C, Epstein, E, Chiappa, V, Fischerova, D, Fruscio, R, Zannoni, G, Valentin, L, Scambia, G, Testa, A, Zannoni, G F, Testa, A C, Pozzati, F, Moro, F, Pasciuto, T, Gallo, C, Ciccarone, F, Franchi, D, Mancari, R, Giunchi, S, Timmerman, D, Landolfo, C, Epstein, E, Chiappa, V, Fischerova, D, Fruscio, R, Zannoni, G, Valentin, L, Scambia, G, Testa, A, Zannoni, G F, and Testa, A C
- Abstract
Objective: To describe the clinical and ultrasound characteristics of ovarian pure clear cell carcinoma. Methods: This was a retrospective study involving data from 11 ultrasound centers. From the International Ovarian Tumor Analysis (IOTA) database, 105 patients who had undergone preoperative ultrasound examination by an experienced ultrasound examiner between 1999 and 2016 were identified with a histologically confirmed pure clear cell carcinoma of the ovary. An additional 47 patients diagnosed with pure clear cell carcinoma between 1999 and 2016 and with available complete preoperative ultrasound reports were identified retrospectively from the databases of the departments of gynecological oncology in the participating centers. The ultrasound images of all tumors were described using IOTA terminology. Clinical and ultrasound characteristics were analyzed for the whole group, and separately, for patients with and those without histologically confirmed endometriosis, and for patients with evidence of tumor developing from endometriosis. Results: Median age of the 152 patients was 53.5 (range, 28–92) years and 92/152 (60.5%) tumors were FIGO Stage I. Most tumors (128/152, 84.2%) were unilateral. On ultrasound examination, all tumors contained solid components and 36/152 (23.7%) were completely solid masses. The median largest diameter of the lesion was 117 (range, 25–310) mm. Papillary projections were present in 58/152 (38.2%) masses and, in most of these (51/56, 91.1%), vascularized papillary projections were seen. Information regarding the presence, site and type of pelvic endometriosis at histology was available for 130/152 patients. Endometriosis was noted in 54 (41.5%) of these. In 24/130 (18.6%) patients, the tumor was judged to have developed from endometriosis. Patients with, compared to those without, evidence of tumor developing from endometriosis were younger (median 47.5 vs 55.0 years, respectively), and ground-glass echogenicity of cyst fluid was more
- Published
- 2018
11. Imaging in gynecological disease (14): clinical and ultrasound characteristics of ovarian clear cell carcinoma
- Author
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Pozzati, Federica, Moro, Francesca, Pasciuto, Tina, Gallo, C, Ciccarone, F, Franchi, D, Mancari, R, Giunchi, S, Timmerman, D, Landolfo, C, Epstein, E, Chiappa, V, Fischerova, D, Fruscio, R, Zannoni, Gian Franco, Valentin, L, Scambia, Giovanni, Testa, Antonia Carla, Pozzati, F, Moro, F, Pasciuto, T (ORCID:0000-0003-2959-8571), Zannoni, G F (ORCID:0000-0003-1809-129X), Scambia, G (ORCID:0000-0003-2758-1063), Testa, AC (ORCID:0000-0003-2217-8726), Pozzati, Federica, Moro, Francesca, Pasciuto, Tina, Gallo, C, Ciccarone, F, Franchi, D, Mancari, R, Giunchi, S, Timmerman, D, Landolfo, C, Epstein, E, Chiappa, V, Fischerova, D, Fruscio, R, Zannoni, Gian Franco, Valentin, L, Scambia, Giovanni, Testa, Antonia Carla, Pozzati, F, Moro, F, Pasciuto, T (ORCID:0000-0003-2959-8571), Zannoni, G F (ORCID:0000-0003-1809-129X), Scambia, G (ORCID:0000-0003-2758-1063), and Testa, AC (ORCID:0000-0003-2217-8726)
- Abstract
N/A
- Published
- 2018
12. Imaging in gynecological disease (13): clinical and ultrasound characteristics of endometrioid ovarian cancer
- Author
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Moro, Francesca, Magoga, G., Pasciuto, Tina, Mascilini, Floriana, Moruzzi, M. C., Fischerova, D., Savelli, L., Giunchi, S., Mancari, R., Franchi, D., Czekierdowski, A., Froyman, W., Verri, D., Epstein, E., Chiappa, V., Guerriero, S., Zannoni, Gian Franco, Timmerman, D., Scambia, Giovanni, Valentin, L., Testa, Antonia Carla, Moro, F., Pasciuto, T. (ORCID:0000-0003-2959-8571), Mascilini, F., Zannoni, G. F. (ORCID:0000-0003-1809-129X), Scambia, G. (ORCID:0000-0003-2758-1063), Testa, A. C. (ORCID:0000-0003-2217-8726), Moro, Francesca, Magoga, G., Pasciuto, Tina, Mascilini, Floriana, Moruzzi, M. C., Fischerova, D., Savelli, L., Giunchi, S., Mancari, R., Franchi, D., Czekierdowski, A., Froyman, W., Verri, D., Epstein, E., Chiappa, V., Guerriero, S., Zannoni, Gian Franco, Timmerman, D., Scambia, Giovanni, Valentin, L., Testa, Antonia Carla, Moro, F., Pasciuto, T. (ORCID:0000-0003-2959-8571), Mascilini, F., Zannoni, G. F. (ORCID:0000-0003-1809-129X), Scambia, G. (ORCID:0000-0003-2758-1063), and Testa, A. C. (ORCID:0000-0003-2217-8726)
- Abstract
OBJECTIVE: To describe the clinical and ultrasound characteristics of ovarian pure endometrioid carcinomas.METHODS: This was a retrospective multicenter study of patients with a histological diagnosis of pure endometrioid carcinoma. We identified 161 patients from the International Ovarian Tumor Analysis (IOTA) database who had undergone preoperative ultrasound examination by an experienced ultrasound examiner between 1999 and 2016, and another 78 patients from the databases of the departments of gynecological oncology in the participating centers. All tumors were described using IOTA terminology. In addition, one author reviewed all available ultrasound images and described them using pattern recognition.RESULTS: Median age of the 239 patients was 55 years (range, 19-88 years). On ultrasound examination, two (0.8%) endometrioid carcinomas were described as unilocular cysts, three (1.3%) as multilocular cysts, 37 (15.5%) as unilocular-solid cysts, 115 (48.1%) as multilocular-solid cysts and 82 (34.3%) as solid masses. Median largest tumor diameter was 102.5 mm (range, 20-300 mm) and median largest diameter of the largest solid component was 63 mm (range, 9-300 mm). Papillary projections were present in 70 (29.3%) masses. Most cancers (188 (78.7%)) were unilateral. In 49 (20.5%) cases, the cancer was judged by the pathologist to develop from endometriosis. These cancers, compared with those without evidence of tumor developing from endometriosis, more often manifested papillary projections on ultrasound (46.9% (23/49) vs 24.7% (47/190)), were less often bilateral (8.2% (4/49) vs 24.7% (47/190)) and less often associated with ascites (6.1% (3/49) vs 28.4% (54/190)) and fluid in the pouch of Douglas (24.5% (12/49) vs 48.9% (93/190)). Retrospective analysis of available ultrasound images using pattern recognition revealed that many tumors without evidence of tumor developing from endometriosis (36.3% (41/113)) had a large central solid component entrapped within locules
- Published
- 2018
13. Imaging in gynecological disease (13): clinical and ultrasound characteristics of endometrioid ovarian cancer
- Author
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Moro, F., primary, Magoga, G., additional, Pasciuto, T., additional, Mascilini, F., additional, Moruzzi, M. C., additional, Fischerova, D., additional, Savelli, L., additional, Giunchi, S., additional, Mancari, R., additional, Franchi, D., additional, Czekierdowski, A., additional, Froyman, W., additional, Verri, D., additional, Epstein, E., additional, Chiappa, V., additional, Guerriero, S., additional, Zannoni, G. F., additional, Timmerman, D., additional, Scambia, G., additional, Valentin, L., additional, and Testa, A. C., additional
- Published
- 2018
- Full Text
- View/download PDF
14. P30.10: Ultrasound and clinical features of uterine carcinosarcoma
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Giunchi, S., primary, Borghese, G.M., additional, Vittori Antisari, G., additional, Ambrosio, M., additional, Savelli, L., additional, and De Iaco, P., additional
- Published
- 2017
- Full Text
- View/download PDF
15. OP20.05: Ultrasound features of uterine leiomyosarcomas
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Ludovisi, M., primary, Giunchi, S., additional, Savelli, L., additional, Franchi, D., additional, Mancari, R., additional, Di Noi, S., additional, Pasciuto, T., additional, Sladkevicius, P., additional, Guerriero, S., additional, Pascual, M., additional, Alcazar, J., additional, Jurkovic, D., additional, Exacoustos, C., additional, Chiappa, V., additional, Epstein, E., additional, Fruhauf, P., additional, Fischerová, D., additional, Fruscio, R., additional, Zannoni, G., additional, Scambia, G., additional, Valentin, L., additional, and Testa, A.C., additional
- Published
- 2017
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16. P11.03: Ultrasound features of ovarian carcinoma in patients with BRCA 1 or BRCA 2 mutation
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Giunchi, S., primary, Vittori Antisari, G., additional, Borghese, G.M., additional, Tesei, M., additional, Perrone, A., additional, and De Iaco, P., additional
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- 2017
- Full Text
- View/download PDF
17. OP20.03: Ultrasound features of endometrial stromal sarcomas
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Ludovisi, M., primary, Giunchi, S., additional, Moruzzi, M., additional, Savelli, L., additional, Mancari, R., additional, Pasciuto, T., additional, Franchi, D., additional, Sladkevicius, P., additional, Guerriero, S., additional, Pascual, M., additional, Alcazar, J., additional, Jurkovic, D., additional, Chiappa, V., additional, Exacoustos, C., additional, Epstein, E., additional, Fruhauf, P., additional, Fischerová, D., additional, Fruscio, R., additional, Zannoni, G., additional, Scambia, G., additional, Valentin, L., additional, and Testa, A.C., additional
- Published
- 2017
- Full Text
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18. OC26: The role of PET/CT in evaluation of sonographically difficult adnexal masses
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Giunchi S, Kuleva M, Ghi T, Armillotta F, Castellucci P, Savelli L, Perrone AM, FANTI, STEFANO, PELUSI, GIUSEPPE, Giunchi S, Kuleva M, Ghi T, Armillotta F, Fanti S, Castellucci P, Savelli L, Perrone AM, and Pelusi G.
- Published
- 2007
19. 3D ultrasound in evaluation of local diffusion of cervical cancer
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Giunchi S., Mabrouk M., Arcangeli T., Savelli L., Ghi T., PELUSI, GIUSEPPE, Giunchi S., Mabrouk M., Arcangeli T., Savelli L., Ghi T., and Pelusi G.
- Published
- 2006
20. OP14.03: Ultrasound features of uterine sarcomas
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Ludovisi, M., primary, Moruzzi, M., additional, Ghi, T., additional, Giunchi, S., additional, Savelli, L., additional, Franchi, D., additional, Mancari, R., additional, Foo, X., additional, Di Legge, A., additional, Di Noi, S., additional, Pasciuto, T., additional, Valentin, L., additional, Jurkovic, D., additional, Scambia, G., additional, and Testa, A.C., additional
- Published
- 2016
- Full Text
- View/download PDF
21. OP29.05: The importance of papillary projection in a small unilocular-solid cyst
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Giunchi, S., primary, Pesaresi, M., additional, Fabbri, F., additional, Mollo, F., additional, and Savelli, L., additional
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- 2012
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22. P28.07: The importance of papillary projection in a small unilocular‐solid cyst
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Giunchi, S., primary, Savelli, L., additional, Pesaresi, M., additional, Kuleva, M., additional, and Rizzo, N., additional
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- 2011
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23. OC27.05: Uterine sarcomas: clinical and sonographic characteristics
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Giunchi, S., primary, Testa, A., additional, Ghi, T., additional, Savelli, L., additional, Pesaresi, M., additional, Mascilini, F., additional, Giordano, M., additional, and Pelusi, G., additional
- Published
- 2010
- Full Text
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24. OC10.02: Common transvaginal sonographic features of adnexal/ovarian torsion
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Giunchi, S., primary, Kuleva, M., additional, Savelli, L., additional, Pesaresi, M., additional, Ghi, T., additional, Guasina, F., additional, and Pelusi, G., additional
- Published
- 2010
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25. OC23.03: Comparison of the diagnostic accuracy of expert transvaginal ultrasound and PET/CT in the evaluation of adnexal masses
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Giunchi, S., primary, Kuleva, M., additional, Ghi, T., additional, Marra, E., additional, Fanti, S., additional, Castellucci, P., additional, Armillotta, F., additional, Savelli, L., additional, and Pelusi, G., additional
- Published
- 2009
- Full Text
- View/download PDF
26. OP35.07: Are all the papillae equals? An analysis of ovarian masses with papillary projections
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Savelli, L., primary, Giunchi, S., additional, Pelusi, G., additional, Berra, G., additional, and Venturoli, S., additional
- Published
- 2009
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27. Oocyte freezing methodologies at an italian assisted reproduction centre
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Bartolotti, T., primary, Felletti, V., additional, Camerani, M.F., additional, Di Nenno, L., additional, Giunchi, S., additional, and Sintini, G., additional
- Published
- 2008
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28. P41.12: Unilaterally increased uterine arteries resistance in the third trimester and pregnancy outcome
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Ghi, T., primary, Kuleva, M., additional, Maroni, E., additional, Auriemma, S., additional, D'Emidio, L., additional, Alesi, L., additional, Giunchi, S., additional, Pilu, G., additional, and Pelusi, G., additional
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- 2007
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29. OC26: The role of PET/CT in evaluation of sonographically difficult adnexal masses
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Giunchi, S., primary, Kuleva, M., additional, Ghi, T., additional, Armillotta, F., additional, Fanti, S., additional, Castellucci, P., additional, Savelli, L., additional, Perrone, A. M., additional, and Pelusi, G., additional
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- 2007
- Full Text
- View/download PDF
30. P43.06: Accuracy of transvaginal ultrasound in evaluation of solid adnexal masses
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Kuleva, M., primary, Giunchi, S., additional, Ghi, T., additional, Marra, E., additional, Savelli, L., additional, and Pelusi, G., additional
- Published
- 2007
- Full Text
- View/download PDF
31. P21.02: Three-dimensional ultrasound in evaluation of local diffusion of cervical cancer
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Giunchi, S., primary, Mabrook, M., additional, Arcangeli, T., additional, Savelli, L., additional, Ghi, T., additional, and Pelusi, G., additional
- Published
- 2006
- Full Text
- View/download PDF
32. Four healthy children from frozen human oocytes and frozen human sperms.
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Porcu, E, primary, Fabbri, R, additional, Ciotti, P, additional, Giunchi, S, additional, Fratto, R, additional, and Caracciolo, D, additional
- Published
- 2001
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33. Clinical experience and applications of oocyte cryopreservation
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Porcu, E, primary, Fabbri, R, additional, Damiano, G, additional, Giunchi, S, additional, Fratto, R, additional, Ciotti, PM, additional, Venturoli, S, additional, and Flamigni, C, additional
- Published
- 2000
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34. Obstetric, Perinatal Outcome and Follow Up of Children Conceived from Cryopreserved Oocytes
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Porcu, E, primary, Fabbri, R, additional, Seracchioli, R, additional, De Cesare, R, additional, Giunchi, S, additional, and Caracciolo, D, additional
- Published
- 2000
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35. Twenty Years Follow-up of Adolescents With Irregular Cycles
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Porcu, E, primary, Venturoli, S, additional, Giunchi, S, additional, Fratto, R, additional, Alfieri, S, additional, and Caracciolo, D, additional
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- 2000
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36. P-088. Comparative effect of the plasma protein fraction (plasmanate) and FCS on granulosa cell cultures
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Fabbri, R., primary, Marsella, T., additional, Primavera, M.R., additional, Savelli, L., additional, Ghi, T., additional, Damiano, S., additional, Giunchi, S., additional, Porcu, F., additional, and Flamigni, C., additional
- Published
- 1997
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37. OP14.04: Ultrasound features in ovarian and uterine lymphomas.
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Giunchi, S., Tesei, M., Vittori Antisari, G., Savelli, L., and De Iaco, P.
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- *
LYMPHOMAS , *OVARIAN cancer , *COLOR Doppler ultrasonography - Abstract
An abstract of the article "Ultrasound features in ovarian and uterine lymphomas," by S. Giunchi and colleagues is presented.
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- 2016
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38. Imaging in gynecological disease (14): clinical and ultrasound characteristics of ovarian clear cell carcinoma
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Francesca Ciccarone, Dirk Timmerman, Francesca Moro, Giovanni Scambia, C. Gallo, F. Pozzati, S. Giunchi, Gianfranco Zannoni, Elisabeth Epstein, Daniela Fischerova, Valentina Chiappa, D. Franchi, R. Mancari, Chiara Landolfo, Lil Valentin, Robert Fruscio, Tina Pasciuto, Antonia Carla Testa, Pozzati, F, Moro, F, Pasciuto, T, Gallo, C, Ciccarone, F, Franchi, D, Mancari, R, Giunchi, S, Timmerman, D, Landolfo, C, Epstein, E, Chiappa, V, Fischerova, D, Fruscio, R, Zannoni, G, Valentin, L, Scambia, G, and Testa, A
- Subjects
Adult ,medicine.medical_specialty ,Endometriosis ,ovarian neoplasm ,clear cell ovarian carcinoma ,03 medical and health sciences ,Ovarian tumor ,0302 clinical medicine ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Cyst ,Clear-cell ovarian carcinoma ,Aged ,Retrospective Studies ,Ultrasonography ,Aged, 80 and over ,Ovarian Neoplasms ,030219 obstetrics & reproductive medicine ,Radiological and Ultrasound Technology ,business.industry ,Ultrasound ,Age Factors ,Obstetrics and Gynecology ,Echogenicity ,ultrasonography ,General Medicine ,ovarian neoplasms ,Middle Aged ,medicine.disease ,pure clear cell ovarian carcinoma ,Reproductive Medicine ,030220 oncology & carcinogenesis ,Clear cell carcinoma ,Female ,Radiology ,business ,Clear cell ,Adenocarcinoma, Clear Cell - Abstract
OBJECTIVE: To describe the clinical and ultrasound characteristics of ovarian pure clear cell carcinoma. METHODS: This was a retrospective study involving data from 11 ultrasound centers. From the International Ovarian Tumor Analysis (IOTA) database, 105 patients who had undergone preoperative ultrasound examination by an experienced ultrasound examiner between 1999 and 2016 were identified with a histologically confirmed pure clear cell carcinoma of the ovary. An additional 47 patients diagnosed with pure clear cell carcinoma between 1999 and 2016 and with available complete preoperative ultrasound reports were identified retrospectively from the databases of the departments of gynecological oncology in the participating centers. The ultrasound images of all tumors were described using IOTA terminology. Clinical and ultrasound characteristics were analyzed for the whole group, and separately, for patients with and those without histologically confirmed endometriosis, and for patients with evidence of tumor developing from endometriosis. RESULTS: Median age of the 152 patients was 53.5 (range, 28-92) years and 92/152 (60.5%) tumors were FIGO Stage I. Most tumors (128/152, 84.2%) were unilateral. On ultrasound examination, all tumors contained solid components and 36/152 (23.7%) were completely solid masses. The median largest diameter of the lesion was 117 (range, 25-310) mm. Papillary projections were present in 58/152 (38.2%) masses and, in most of these (51/56, 91.1%), vascularized papillary projections were seen. Information regarding the presence, site and type of pelvic endometriosis at histology was available for 130/152 patients. Endometriosis was noted in 54 (41.5%) of these. In 24/130 (18.6%) patients, the tumor was judged to have developed from endometriosis. Patients with, compared to those without, evidence of tumor developing from endometriosis were younger (median 47.5 vs 55.0 years, respectively), and ground-glass echogenicity of cyst fluid was more common in pure clear cell cancers developing from endometriosis (10/20 vs 13/79 (50.0% vs 16.5%), respectively). CONCLUSIONS: Ovarian pure clear cell carcinoma is usually diagnosed at an early stage and typically appears as a large unilateral mass with solid components. Patients with clear cell carcinoma developing from endometriosis are younger than other patients with clear cell carcinoma, and clear cell cancers developing from endometriosis more often manifest ground-glass echogenicity of cyst fluid. Copyright © 2018 ISUOG. Published by John Wiley & Sons Ltd. ispartof: Ultrasound In Obstetrics & Gynecology vol:52 issue:6 pages:792-800 ispartof: location:England status: published
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- 2018
39. COVID-19 free oncologic surgical hub: The experience of reallocation of a gynecologic oncology unit during pandemic outbreak
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Anna Myriam Perrone, Eugenia De Crescenzo, Antonio De Leo, Rocco D'Andrea, Claudio Zamagni, Safia Boussedra, Alessio G. Morganti, S. Giunchi, Marco Tesei, Pierandrea De Iaco, Alessandra De Palma, Giulia Dondi, Perrone A.M., Dondi G., Giunchi S., De Crescenzo E., Boussedra S., Tesei M., D'Andrea R., De Leo A., Zamagni C., Morganti A.G., De Palma A., and De Iaco P.
- Subjects
0301 basic medicine ,Adult ,medicine.medical_specialty ,Genital Neoplasms, Female ,Gynecologic oncology ,Gynaecological cancers ,Health Services Accessibility ,Article ,Unit (housing) ,Disease Outbreaks ,Health care rationing ,Hospitals, University ,03 medical and health sciences ,0302 clinical medicine ,Gynecologic Surgical Procedures ,Ovarian cancer ,Obstetrics and Gynaecology ,Pandemic ,Health care ,medicine ,Infection control ,Humans ,Allocation resources ,Prospective Studies ,Prospective cohort study ,Pandemics ,Aged ,Gynaecological cancer ,Infection Control ,Allocation resource ,Health Care Rationing ,business.industry ,SARS-CoV-2 ,General surgery ,Obstetrics and Gynecology ,COVID-19 ,Middle Aged ,030104 developmental biology ,Oncology ,Italy ,030220 oncology & carcinogenesis ,Observational study ,Female ,business - Abstract
Introduction During the SARS-CoV-2 pandemic, the majority of healthcare resources of the affected Italian regions were allocated to COVID-19 patients. Due to lack of resources and high risk of death, most cancer patients have been shifted to non-surgical treatments. The following reports our experience of a Gynaecologic Oncology Unit's reallocation of resources in a COVID-19 free surgical oncologic hub in order to guarantee standard quality of surgical activities. Materials and methods This is a prospective observational study performed in the Gynaecologic Oncology Unit, on the outcomes of the reallocation of surgical activities outside the University Hospital of Bologna, Italy, during the Italian lockdown period. Here, we described our COVID-19 free surgical oncologic pathway, in terms of lifestyle restrictions, COVID-19 screening measures, and patient clinical, surgical and follow up outcomes. Results During the lockdown period (March 9th – May 4th, 2020), 83 patients were scheduled for oncological surgery, 51 patients underwent surgery. Compared to pre-COVID period, we performed the same activities: number of cases scheduled for surgery, type of surgery and surgical and oncological results. No cases of COVID-19 infection were recorded in operated patients and in medical staff. Patients were compliant and well accepted the lifestyle restrictions and reorganization of the care. CONCLUSIONSonclusions Our experience showed that the prioritization of oncological surgical care and the allocation of resources during a pandemic in COVID-19 free surgical hubs is an appropriate choice to guarantee oncological protocols., Highlights • SARS-CoV-2 has rapidly spread worldwide from China. • Oncologic international societies advised to reduce surgical procedures. • We report an experience of COVID-19 free Surgical Hubs in gynaecologic oncology. • Reallocation of resources in COVID-19 free Surgical Hubs is effective.
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- 2020
40. Imaging in gynecological disease (15): clinical and ultrasound characteristics of uterine sarcoma
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Giovanni Scambia, Lil Valentin, Juan Luis Alcázar, Luca Savelli, Gianfranco Zannoni, Stefano Guerriero, Elisabeth Epstein, Tina Pasciuto, S. Giunchi, Povilas Sladkevicius, R. Mancari, Daniela Fischerova, Francesca Ciccarone, Caterina Exacoustos, A. C. Testa, Dorella Franchi, Francesca Moro, M. C. Moruzzi, Maria Angela Pascual, F. Frühauf, S. Di Noi, Robert Fruscio, Manuela Ludovisi, Valentina Chiappa, Davor Jurkovic, Ludovisi, M, Moro, F, Pasciuto, T, Di Noi, S, Giunchi, S, Savelli, L, Pascual, M, Sladkevicius, P, Alcazar, J, Franchi, D, Mancari, R, Moruzzi, M, Jurkovic, D, Chiappa, V, Guerriero, S, Exacoustos, C, Epstein, E, Frühauf, P, Fischerova, D, Fruscio, R, Ciccarone, F, Zannoni, G, Scambia, G, Valentin, L, and Testa, A
- Subjects
Leiomyosarcoma ,Adult ,medicine.medical_specialty ,sarcoma ,endometrial stromal sarcoma ,leiomyosarcoma ,pattern recognition ,ultrasonography ,Aged ,Aged, 80 and over ,Endometrial Neoplasms ,Female ,Humans ,Middle Aged ,Retrospective Studies ,Sarcoma, Endometrial Stromal ,Ultrasonography, Doppler, Color ,Uterine Neoplasms ,Color ,Endometrial Stromal ,03 medical and health sciences ,0302 clinical medicine ,medicine ,80 and over ,Radiology, Nuclear Medicine and imaging ,Cyst ,Vaginal bleeding ,030212 general & internal medicine ,030219 obstetrics & reproductive medicine ,Endometrial stromal sarcoma ,Radiological and Ultrasound Technology ,Uterine sarcoma ,business.industry ,Ultrasound ,Doppler ,Obstetrics and Gynecology ,Echogenicity ,General Medicine ,medicine.disease ,Reproductive Medicine ,Settore MED/40 ,Sarcoma ,Radiology ,medicine.symptom ,business - Abstract
Objective To describe the clinical and ultrasound characteristics of uterine sarcomas. Methods This was a retrospective multicenter study. From the databases of 13 ultrasound centers, we identified patients with a histological diagnosis of uterine sarcoma with available ultrasound reports and ultrasound images who had undergone preoperative ultrasound examination between 1996 and 2016. As the first step, each author collected information from the original ultrasound reports from his/her own center on predefined ultrasound features of the tumors and by reviewing the ultrasound images to identify information on variables not described in the original report. As the second step, 16 ultrasound examiners reviewed the images electronically in a consensus meeting and described them using predetermined terminology. Results We identified 116 patients with leiomyosarcoma, 48 with endometrial stromal sarcoma and 31 with undifferentiated endometrial sarcoma. Median age of the patients was 56 years (range, 26-86 years). Most patients were symptomatic at diagnosis (164/183 (89.6%)), the most frequent presenting symptom being abnormal vaginal bleeding (91/183 (49.7%)). Patients with endometrial stromal sarcoma were younger than those with leiomyosarcoma and undifferentiated endometrial sarcoma (median age, 46 years vs 57 and 60 years, respectively). According to the assessment by the original ultrasound examiners, the median diameter of the largest tumor was 91 mm (range, 7-321 mm). Visible normal myometrium was reported in 149/195 (76.4%) cases, and 80.0% (156/195) of lesions were solitary. Most sarcomas (155/195 (79.5%)) were solid masses (> 80% solid tissue), and most manifested inhomogeneous echogenicity of the solid tissue (151/195 (77.4%)); one sarcoma was multilocular without solid components. Cystic areas were described in 87/195 (44.6%) tumors and most cyst cavities had irregular walls (67/87 (77.0%)). Internal shadowing was observed in 42/192 (21.9%) sarcomas and fan-shaped shadowing in 4/192 (2.1%). Moderate or rich vascularization was found on color-Doppler examination in 127/187 (67.9%) cases. In 153/195 (78.5%) sarcomas, the original ultrasound examiner suspected malignancy. Though there were some differences, the results of the first and second steps of the analysis were broadly similar. Conclusions Uterine sarcomas typically appear as solid masses with inhomogeneous echogenicity, sometimes with irregular cystic areas but only very occasionally with fan-shaped shadowing. Most are moderately or very well vascularized. Copyright © 2019 ISUOG. Published by John Wiley & Sons Ltd.
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- 2018
41. Neonatal hypoxic-ischemic encephalopathy in apparently low risk pregnancies: retrospective analysis of the last five years at the University of Bologna
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Giuseppe Pelusi, Maria Cristina Meriggiola, S. Giunchi, Gina Ancora, Aly Youssef, Guido Cocchi, Gianluigi Pilu, Tullio Ghi, Carla Pelusi, Giacomo Faldella, T. Arcangeli, Antonio Maria Morselli-Labate, Ghi T, Giunchi S, Pilu G, Youssef A, Morselli-Labate AM, Arcangeli T, Meriggiola MC, Pelusi C, Ancora G, Cocchi G, Faldella G, and Pelusi G.
- Subjects
Male ,Risk ,Pediatrics ,medicine.medical_specialty ,Amniotic fluid ,Encephalopathy ,Maternal Fever ,Hypoxic Ischemic Encephalopathy ,Infant, Newborn, Diseases ,Cerebral palsy ,Hospitals, University ,Pregnancy ,Intensive Care Units, Neonatal ,Medicine ,Humans ,Retrospective Studies ,Asphyxia Neonatorum ,business.industry ,Infant, Newborn ,Obstetrics and Gynecology ,Odds ratio ,medicine.disease ,Delivery, Obstetric ,Confidence interval ,Perinatal asphyxia ,Pregnancy Complications ,Italy ,Case-Control Studies ,Pediatrics, Perinatology and Child Health ,Hypoxia-Ischemia, Brain ,Female ,business - Abstract
To provide recent figures on the occurrence of neonatal hypoxic-ischemic encephalopathy (NHIE) from a Teaching Hospital.A retrospective case-control study was conducted in a tertiary level university hospital with more than 3000 deliveries annually. Twenty-four cases of NHIE that occurred in apparently low-risk pregnancies were analysed and compared to a group of controls for the most common labor variables. Odds ratios (OR) and 95% confidence intervals (CI) were calculated.Of 15,371 apparently low-risk deliveries, 24 cases of NHIE were observed (0.16%), with perinatal death or cerebral palsy occurring in nine of these cases (0.06%). The following intra-partum variables were significantly more common in cases than in controls: stained amniotic fluid (OR: 7.50; 95% CI:1.77-31.79), maternal fever (none in the control group), abnormal CTG (OR: 253.0; 95% CI: 26.70-2397), persistent occiput posterior (OR: 15.67; 95% CI: 2.25-104.53) and operative delivery (OR: 3.98; 95% CI: 1.39-11.33).The incidence of NHIE is considerably low in a Tertiary care Centre.
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- 2009
42. Oocyte cryopreservation in oncological patients
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Eleonora Porcu, Giuseppe Damiano, Raffaella Fabbri, S. Giunchi, Stefano Venturoli, Rosita Fratto, Porcu E., Fabbri R., Damiano G., Fratto R., Giunchi S., and Venturoli S
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Oncology ,Adult ,medicine.medical_specialty ,Adolescent ,medicine.medical_treatment ,Cryopreservation ,Ovarian function ,Internal medicine ,Neoplasms ,medicine ,Humans ,Ovarian tissue cryopreservation ,Chemotherapy ,business.industry ,Neoplastic disease ,Obstetrics and Gynecology ,Oocyte cryopreservation ,Oocyte ,Surgery ,Radiation therapy ,medicine.anatomical_structure ,Reproductive Medicine ,Italy ,Oocytes ,Female ,business - Abstract
The use of chemotherapy and radiotherapy in oncological patients may reduce their reproductive potential. Sperm cryopreservation has been already used in men affected by neoplastic disease. Oocyte cryopreservation might be an important solution for these patients at risk of losing ovarian function. A program of oocyte cryopreservation for oncological patients is also present in our center. From June 1996 to January 2000, 18 patients awaiting chemotherapy and radiotherapy for neoplastic disease were included in our oocyte cryopreservation program. Our experience documents that oocyte storage may be a concrete and pragmatic alternative for oncological patients. The duration of oocyte storage does not seem to interfere with oocyte survival as pregnancies occurred even after several years of gamete cryopreservation in liquid nitrogen.
- Published
- 2004
43. Optimal number of neoadjuvant chemotherapy cycles prior to interval debulking surgery in advanced epithelial ovarian cancer: a systematic review and meta-analysis of progression-free survival and overall survival.
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Coada CA, Dondi G, Ravegnini G, Di Costanzo S, Tesei M, Fiuzzi E, Di Stanislao M, Giunchi S, Zamagni C, Bovicelli A, Hrelia P, Angelini S, De Iaco P, and Perrone AM
- Subjects
- Humans, Female, Carcinoma, Ovarian Epithelial drug therapy, Carcinoma, Ovarian Epithelial surgery, Progression-Free Survival, Cytoreduction Surgical Procedures, Chemotherapy, Adjuvant methods, Neoadjuvant Therapy methods, Ovarian Neoplasms drug therapy, Ovarian Neoplasms surgery
- Abstract
Objective: Neoadjuvant chemotherapy (NACT) represents a treatment option in patients with advanced epithelial ovarian cancer (AEOC) who are not good candidates for primary debulking surgery. Usually, 3 cycles of chemotherapy before surgery have been considered the best option for patient survival, although quite often some patients receive more than 3 cycles. The aim of this systematic review and meta-analysis was to identify the optimal number of NACT cycles reporting better survival in AEOC patients., Methods: PubMed, Cochrane Library, and Scopus were searched for original articles that analyzed the relationship between the number of chemotherapy cycles and clinical outcomes in AEOC patients before interval debulking surgery (IDS). The main outcomes were progression-free survival (PFS) and overall survival (OS)., Results: A total of 22 studies comprising 7,005 patients diagnosed with AEOC were included in our analysis. In terms of survival, the reviewed studies dividing the patients in ≤3 NACT cycles vs. >3, showed a trend for a decrease in PFS and a significant reduction in OS with an increasing number of cycles, while a difference in both PFS and OS was revealed if early IDS included patients with 4 NACT cycles. These results should be interpreted with caution due to the complex characteristics of AEOC patients., Conclusion: In conclusion, our review and meta-analysis revealed that there is not enough evidence to determine the optimal number of NACT treatments before surgery. Further research in the form of well-designed randomized controlled trials is necessary to address this issue., Trial Registration: PROSPERO Identifier: CRD42022334959., Competing Interests: No potential conflict of interest relevant to this article was reported., (© 2023. Asian Society of Gynecologic Oncology, Korean Society of Gynecologic Oncology, and Japan Society of Gynecologic Oncology.)
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- 2023
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44. Prognostic Impact of Pathologic Features in Molecular Subgroups of Endometrial Carcinoma.
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Ruscelli M, Maloberti T, Corradini AG, Rosini F, Querzoli G, Grillini M, Altimari A, Gruppioni E, Sanza V, Costantino A, Ciudino R, Errani M, Papapietro A, Coluccelli S, Turchetti D, Ferioli M, Giunchi S, Dondi G, Tesei M, Ravegnini G, Abbati F, Rubino D, Zamagni C, D'Angelo E, De Iaco P, Santini D, Ceccarelli C, Perrone AM, Tallini G, de Biase D, and De Leo A
- Abstract
The molecular characterization of endometrial carcinoma (EC) has recently been included in the ESGO/ESTRO/ESP guidelines. The study aims to evaluate the impact of integrated molecular and pathologic risk stratification in the clinical practice and the relevance of pathologic parameters in predicting prognosis in each EC molecular subgroup. ECs were classified using immunohistochemistry and next-generation sequencing into the four molecular classes: POLE mutant ( POLE ), mismatch repair deficient (MMRd), p53 mutant (p53abn), and no specific molecular profile (NSMP). According to the WHO algorithm, 219 ECs were subdivided into the following molecular subgroups: 7.8% POLE , 31% MMRd, 21% p53abn, 40.2% NSMP. Molecular classes as well as ESGO/ESTRO/ESP 2020 risk groups were statistically correlated with disease-free survival. Considering the impact of histopathologic features in each molecular class, stage was found to be the strongest prognostic factor in MMRd ECs, whereas in the p53abn subgroup, only lymph node status was associated with recurrent disease. Interestingly, in the NSMP tumor, several histopathologic features were correlated with recurrence: histotype, grade, stage, tumor necrosis, and substantial lymphovascular space invasion. Considering early-stage NSMP ECs, substantial lymphovascular space invasion was the only independent prognostic factor. Our study supports the prognostic importance of EC molecular classification and demonstrated the essential role of histopathologic assessment in patients' management.
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- 2023
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45. Integrated clinicopathologic and molecular analysis of endometrial carcinoma: Prognostic impact of the new ESGO-ESTRO-ESP endometrial cancer risk classification and proposal of histopathologic algorithm for its implementation in clinical practice.
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de Biase D, Maloberti T, Corradini AG, Rosini F, Grillini M, Ruscelli M, Coluccelli S, Altimari A, Gruppioni E, Sanza V, Turchetti D, Galuppi A, Ferioli M, Giunchi S, Dondi G, Tesei M, Ravegnini G, Abbati F, Rubino D, Zamagni C, De Iaco P, Santini D, Ceccarelli C, Perrone AM, Tallini G, and De Leo A
- Abstract
Introduction: The European Society of Gynecologic Oncology/European Society of Radiation Therapy and Oncology/European Society of Pathology (ESGO/ESTRO/ESP) committee recently proposed a new risk stratification system for endometrial carcinoma (EC) patients that incorporates clinicopathologic and molecular features. The aim of the study is to compare the new ESGO/ESTRO/ESP risk classification system with the previous 2016 recommendations, evaluating the impact of molecular classification and defining a new algorithm for selecting cases for molecular analysis to assign the appropriate risk class., Methods: The cohort included 211 consecutive EC patients. Immunohistochemistry and next-generation sequencing were used to assign molecular subgroups of EC: POLE mutant ( POLE ), mismatch repair deficient (MMRd), p53 mutant (p53abn), and no specific molecular profile (NSMP)., Results: Immuno-molecular analysis was successful in all cases, identifying the four molecular subgroups: 7.6% POLE , 32.2% MMRd, 20.9% p53abn, and 39.3% NSMP. The recent 2020 guidelines showed a 32.7% risk group change compared with the previous 2016 classification system: the reassignment is due to POLE mutations, abnormal p53 expression, and a better definition of lymphovascular space invasion. The 2020 system assigns more patients to lower-risk groups (42.2%) than the 2016 recommendation (25.6%). Considering the 2020 risk classification system that includes the difference between "unknown molecular classification" and "known," the integration of molecular subgroups allowed 6.6% of patients to be recategorized into a different risk class. In addition, the use of the proposed algorithm based on histopathologic parameters would have resulted in a 62.6% reduction in molecular analysis, compared to applying molecular classification to all patients., Conclusion: Application of the new 2020 risk classification integrating clinicopathologic and molecular parameters provided more accurate identification of low-and high-risk patients, potentially allowing a more specific selection of patients for post-operative adjuvant therapy. The proposed histopathologic algorithm significantly decreases the number of tests needed and could be a promising tool for cost reduction without compromising prognostic stratification., Competing Interests: DB has received personal fees (as consultant and/or speaker bureau) from Boehringer Ingelheim, and Eli Lilly, unrelated to the current work. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 de Biase, Maloberti, Corradini, Rosini, Grillini, Ruscelli, Coluccelli, Altimari, Gruppioni, Sanza, Turchetti, Galuppi, Ferioli, Giunchi, Dondi, Tesei, Ravegnini, Abbati, Rubino, Zamagni, De Iaco, Santini, Ceccarelli, Perrone, Tallini and De Leo.)
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- 2023
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46. Classification Systems of Endometrial Cancer: A Comparative Study about Old and New.
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Coada CA, Dondi G, Ravegnini G, De Leo A, Santini D, De Crescenzo E, Tesei M, Bovicelli A, Giunchi S, Dormi A, Di Stanislao M, Morganti AG, De Biase D, De Iaco P, and Perrone AM
- Abstract
Endometrial cancer is the most common gynecological malignancy of the female reproductive organs. Historically it was divided into type I and type II, until 2013 when the Cancer Genome Atlas molecular classification was proposed. Here, we applied the different classification types on our endometrial cancer patient cohort in order to identify the most predictive one. We enrolled 117 endometrial cancer patients available for the study and collected the following parameters: age, body mass index, stage, menopause, Lynch syndrome status, parity, hypertension, type of localization of the lesion at hysteroscopy, type of surgery and complications, and presence of metachronous or synchronous tumors. The tumors were classified according to the European Society for Medical Oncology, Proactive Molecular Risk Classifier for Endometrial Cancer, Post-Operative Radiation Therapy in Endometrial Carcinoma, and Cancer Genome Atlas classification schemes. Our data confirmed that European Society for Medical Oncology risk was the strongest predictor of prognosis in our cohort. The parameters correlated with poor prognosis were the histotype, FIGO stage, and grade. Our study cohort shows that risk stratification should be based on the integration of histologic, clinical, and molecular parameters.
- Published
- 2021
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47. COVID-19 free oncologic surgical hub: The experience of reallocation of a gynecologic oncology unit during pandemic outbreak.
- Author
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Perrone AM, Dondi G, Giunchi S, De Crescenzo E, Boussedra S, Tesei M, D'Andrea R, De Leo A, Zamagni C, Morganti AG, De Palma A, and De Iaco P
- Subjects
- Adult, Aged, COVID-19 epidemiology, Disease Outbreaks, Female, Gynecologic Surgical Procedures, Health Care Rationing methods, Hospitals, University organization & administration, Humans, Infection Control methods, Italy epidemiology, Middle Aged, Pandemics, Prospective Studies, COVID-19 prevention & control, Genital Neoplasms, Female surgery, Health Care Rationing organization & administration, Health Services Accessibility organization & administration, Infection Control organization & administration
- Abstract
Introduction: During the SARS-CoV-2 pandemic, the majority of healthcare resources of the affected Italian regions were allocated to COVID-19 patients. Due to lack of resources and high risk of death, most cancer patients have been shifted to non-surgical treatments. The following reports our experience of a Gynaecologic Oncology Unit's reallocation of resources in a COVID-19 free surgical oncologic hub in order to guarantee standard quality of surgical activities., Materials and Methods: This is a prospective observational study performed in the Gynaecologic Oncology Unit, on the outcomes of the reallocation of surgical activities outside the University Hospital of Bologna, Italy, during the Italian lockdown period. Here, we described our COVID-19 free surgical oncologic pathway, in terms of lifestyle restrictions, COVID-19 screening measures, and patient clinical, surgical and follow up outcomes., Results: During the lockdown period (March 9th - May 4th, 2020), 83 patients were scheduled for oncological surgery, 51 patients underwent surgery. Compared to pre-COVID period, we performed the same activities: number of cases scheduled for surgery, type of surgery and surgical and oncological results. No cases of COVID-19 infection were recorded in operated patients and in medical staff. Patients were compliant and well accepted the lifestyle restrictions and reorganization of the care., Conclusionsonclusions: Our experience showed that the prioritization of oncological surgical care and the allocation of resources during a pandemic in COVID-19 free surgical hubs is an appropriate choice to guarantee oncological protocols., Competing Interests: Declaration of Competing Interest Authors declared no conflict of interest., (Copyright © 2020. Published by Elsevier Inc.)
- Published
- 2021
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48. Neonatal hypoxic-ischemic encephalopathy in apparently low risk pregnancies: retrospective analysis of the last five years at the University of Bologna.
- Author
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Ghi T, Giunchi S, Pilu G, Youssef A, Morselli-Labate AM, Arcangeli T, Meriggiola MC, Pelusi C, Ancora G, Cocchi G, Faldella G, and Pelusi G
- Subjects
- Asphyxia Neonatorum complications, Asphyxia Neonatorum epidemiology, Case-Control Studies, Delivery, Obstetric methods, Delivery, Obstetric statistics & numerical data, Female, Hospitals, University, Humans, Hypoxia-Ischemia, Brain congenital, Hypoxia-Ischemia, Brain etiology, Infant, Newborn, Infant, Newborn, Diseases etiology, Intensive Care Units, Neonatal statistics & numerical data, Italy, Male, Pregnancy, Pregnancy Complications epidemiology, Retrospective Studies, Risk, Hypoxia-Ischemia, Brain epidemiology, Infant, Newborn, Diseases epidemiology, Pregnancy Complications etiology
- Abstract
Objective: To provide recent figures on the occurrence of neonatal hypoxic-ischemic encephalopathy (NHIE) from a Teaching Hospital., Study Design: A retrospective case-control study was conducted in a tertiary level university hospital with more than 3000 deliveries annually. Twenty-four cases of NHIE that occurred in apparently low-risk pregnancies were analysed and compared to a group of controls for the most common labor variables. Odds ratios (OR) and 95% confidence intervals (CI) were calculated., Results: Of 15,371 apparently low-risk deliveries, 24 cases of NHIE were observed (0.16%), with perinatal death or cerebral palsy occurring in nine of these cases (0.06%). The following intra-partum variables were significantly more common in cases than in controls: stained amniotic fluid (OR: 7.50; 95% CI:1.77-31.79), maternal fever (none in the control group), abnormal CTG (OR: 253.0; 95% CI: 26.70-2397), persistent occiput posterior (OR: 15.67; 95% CI: 2.25-104.53) and operative delivery (OR: 3.98; 95% CI: 1.39-11.33)., Conclusion: The incidence of NHIE is considerably low in a Tertiary care Centre.
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- 2010
- Full Text
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49. Accuracy of three-dimensional ultrasound in diagnosis and classification of congenital uterine anomalies.
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Ghi T, Casadio P, Kuleva M, Perrone AM, Savelli L, Giunchi S, Meriggiola MC, Gubbini G, Pilu G, Pelusi C, and Pelusi G
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- Adult, Female, Humans, Reproducibility of Results, Sensitivity and Specificity, Imaging, Three-Dimensional methods, Ultrasonography methods, Uterus abnormalities, Uterus diagnostic imaging
- Abstract
Objective: To assess the accuracy of three-dimensional (3D) ultrasound in the diagnosis of congenital uterine anomalies., Design: Prospective study., Setting: University hospital., Patient(s): Nulliparae with three or more consecutive miscarriages., Intervention(s): All women underwent 3D transvaginal ultrasound study of the uterine cavity., Main Outcome Measure(s): Women with negative ultrasound findings subsequently underwent office hysteroscopy, whereas a combined laparoscopic-hysteroscopic assessment was performed in cases of suspected Müllerian anomaly., Result(s): A specific Müllerian malformation was sonographically diagnosed in 54 women of the 284 included in the study group. All negative ultrasound findings were confirmed at office hysteroscopy. Among the women with abnormal ultrasound findings, the presence of a Müllerian anomaly was endoscopically confirmed in all. Concordance between ultrasound and endoscopy around the type of anomaly was verified in 52 cases, including all those with septate uterus and two out of three with bicornuate uterus., Conclusion(s): Volume transvaginal ultrasound appears to be extremely accurate for the diagnosis and classification of congenital uterine anomalies and may conveniently become the only mandatory step in the assessment of the uterine cavity in patients with a history of recurrent miscarriage.
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- 2009
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50. Laparoscopic treatment of interstitial twin pregnancy.
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Casadio P, Formelli G, Spagnolo E, De Angelis D, Marra E, Armillotta F, Salfi N, Ghi T, Giunchi S, Meriggiola MC, Perrone AM, and Pelusi G
- Subjects
- Adult, Female, Humans, Hysteroscopy, Image Processing, Computer-Assisted, Pregnancy, Pregnancy Trimester, First, Twins, Ultrasonography, Uterus surgery, Vagina diagnostic imaging, Laparoscopy methods
- Abstract
Objective: To describe a conservative management by laparoscopy of an unusual interstitial twin pregnancy., Design: Case report., Setting: University hospital., Patient(s): A 27-year-old woman, pregnant at 6th week of amenorrhea with interstitial twin pregnancy., Intervention(s): The woman was submitted to two- and three-dimensional transvaginal ultrasound and to diagnostic hysteroscopy. Subsequently, we performed a laparoscopic procedure: conical exeresis of the uterine cornu using a monopolar hook without involving the uterine cavity., Main Outcome Measure(s): Conservation of the uterus, fertility preservation., Result(s): Successful conservative treatment of interstitial twin pregnancy., Conclusion(s): Conservative laparoscopic surgery can be used successfully in hemodynamically stable patients with an interstitial pregnancy.
- Published
- 2009
- Full Text
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