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2 results on '"Giuseppe De Sanctis"'

1. Prevalence of hepatitis D virus infection in Central Italy has remained stable across the last 2 decades with dominance of subgenotypes 1 and characterized by elevated viral replication

Author

Romina Salpini, Lorenzo Piermatteo, Giulia Torre, Stefano D'Anna, Sohaib Khan, Leonardo Duca, Ada Bertoli, Simone La Frazia, Vincenzo Malagnino, Elisabetta Teti, Marco Iannetta, Pierpaolo Paba, Marco Ciotti, Ilaria Lenci, Simona Francioso, Caterina Paquazzi, Miriam Lichtner, Claudio Mastroianni, Francesco Santopaolo, Giuseppe De Sanctis, Adriano Pellicelli, Giovanni Galati, Alessandra Moretti, Katia Casinelli, Luciano Caterini, Nerio Iapadre, Giustino Parruti, Iacopo Vecchiet, Maurizio Paoloni, Massimo Marignani, Francesca Ceccherini-Silberstein, Leonardo Baiocchi, Sandro Grelli, Loredana Sarmati, and Valentina Svicher

Subjects
Hepatitis D virus, Hepatitis B virus, HDV prevalence, HDV-RNA quantification, HDV chronic infection, Infectious and parasitic diseases, RC109-216
Abstract

Objectives: Here we investigate Hepatitis D virus (HDV)-prevalence in Italy and its fluctuations over time and we provide an extensive characterization of HDV-infected patients. Methods: The rate of HDV seroprevalence and HDV chronicity was assessed in 1579 hepatitis B surface antigen (HBsAg)+ patients collected from 2005 to 2022 in Central Italy. Results: In total, 45.3% of HBsAg+ patients received HDV screening with an increasing temporal trend: 15.6% (2005-2010), 45.0% (2011-2014), 49.4% (2015-2018), 71.8% (2019-2022). By multivariable model, factors correlated with the lack of HDV screening were alanine-aminotransferase (ALT) less than two times of upper limit of normality (

Published
2024
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2. Unexpected rise in the circulation of complex HBV variants enriched of HBsAg vaccine-escape mutations in HBV genotype-D: potential impact on HBsAg detection/quantification and vaccination strategies

Author

Lorenzo Piermatteo, Stefano D’Anna, Ada Bertoli, Maria Bellocchi, Luca Carioti, Lavinia Fabeni, Mohammad Alkhatib, Simone La Frazia, Miriam Lichtner, Claudio Mastroianni, Giuseppe De Sanctis, Massimo Marignani, Caterina Pasquazzi, Nerio Iapadre, Giustino Parruti, Giuseppina Cappiello, Jacopo Vecchiet, Vincenzo Malagnino, Sandro Grelli, Francesca Ceccherini-Silbertein, Massimo Andreoni, Loredana Sarmati, Valentina Svicher, and Romina Salpini

Subjects
HBV, HBsAg, vaccine-escape mutations, HBsAg antigenicity, HBsAg secretion, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502
Abstract

Specific HBsAg mutations are known to hamper HBsAg recognition by neutralizing antibodies thus challenging HBV-vaccination efficacy. Nevertheless, information on their impact and spreading over time is limited. Here, we characterize the circulation of vaccine-escape mutations from 2005 to 2019 and their correlation with virological parameters in a large cohort of patients infected with HBV genotype-D (N = 947), dominant in Europe. Overall, 17.7% of patients harbours ≥1 vaccine-escape mutation with the highest prevalence in subgenotype-D3. Notably, complex profiles (characterized by ≥2 vaccine-escape mutations) are revealed in 3.1% of patients with a prevalence rising from 0.4% in 2005–2009 to 3.0% in 2010–2014 and 5.1% in 2015–2019 (P = 0.007) (OR[95%CI]:11.04[1.42–85.58], P = 0.02, by multivariable-analysis). The presence of complex profiles correlates with lower HBsAg-levels (median[IQR]:40[0–2905]IU/mL for complex profiles vs 2078[115–6037]IU/ml and 1881[410–7622]IU/mL for single or no vaccine-escape mutation [P

Published
2023
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