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12. How do cardiologists select patients for dual antiplatelet therapy continuation beyond 1 year after a myocardial infarction? Insights from the EYESHOT Post-MI Study

Author

De Luca L., Colivicchi F., Meessen J., Uguccioni M., Piscione F., Bernabo P., Lardieri G., Granatelli A., Gabrielli D., Gulizia M. M., Silverio A., Benvenga R. M., Mascia F., Fusco A., Cicala S., Oltrona Visconti L., Marinoni B., Canosi U., Cirillo P., Trimarco B., Ziviello F., Grosseto D., Menozzi M., Mezzena D., Mauro C., Sasso A., Bellis A., Calabro P., Gragnano F., Cesaro A., Venturelli V., Porretta V., Borrelli N., Indolfi C., De Rosa S., Torella D., Morici N., Molfese M., Della Rovere F., Caiffa T., Moretto G., Grippo G., Di Vincenzo E., Lucisano L., Pennacchi M., Geraci G., Sanfilippo N., Ledda A., Di Lenarda A., Cherubini A., Russo G., Piemonte F., Di Donato A., Carraturo A., Villari B., Ciampi Q., Contaldi C., Pacher V., Corrada E., Cattani D., Nassiacos D., Meloni S., Barco B., Bonmassari R., Bertoldi A., Tedoldi F., Cannone M., Valenti G., Musci R. L., Caldarola P., Locuratolo N., Sublimi Saponetti L., Gentili L., Maiandi C., Caputo M., Capparuccia C. A., Tonella T., Massari F. M., Lupi A., Tessitori M., Montano M., Scaglione A., Torri A., Tortorella G., Navazio A., Cemin R., Latina L., Briguglia D., Marino R., Scalvini S., Zanelli E., Paganini V., Riboni G., Leiballi E., Della Mattia A., Imperadore F., Tespili M., Santangelo G., Parravicini U., Dellavesa P., Testa R., Venturini E., Feola M., Testa M., Crisci V., Tramontana M., Robiglio L., Varbella F., Meynet I., Galati A., Maddaluna A., Bilato C., Loddo I., Licciardello G., Cassaniti L., Scherillo M., Formigli D., Marullo L., Chianese L., Paolillo C., De Santis A. P. A., Brunetti N. D., Bottigliero D., Della Bona R., Giannico M. B., Tramarin R., Lucibello S., Perna G. P., Marini M., Colavita A. R., Raziliop A., Francese G. M., Mariani M., Collauto F., D'Urbano M., Naio R., Ando G., Saporito F., Assanelli E. M., Cabiati A., Crivaro A., Alberti S., Marchese I., Nejat T., Refice S., Raino R., Aiello A., Cristinziani G. R., Barilla F., Iorio R., Mascelli G., Tartaglione S. N., Di Chiara G., D'Andrea D., Antonicelli R., Malatesta G., Di Mario C., Mattesini A., Tramontana L., Conti S., Sommariva L., Celestini A., Amico F., Giubilato S., Amico A. F., De Filippis M., Pasini G. F., Triggiani M., Ferrara V., Cappetti S., Carugo S., Lucreziotti S., Persico M., Gizzi G., Cipolla T., Caronia A., Buia E., Pastori P., Scarpignato M., Biscottini E., Poletti F., Vimercati C., Pirola R., Barbieri E., Dugo C., De Cesare N., De Benedictis M. L., Ruggeri A., Campana C., Bonura S., Vigna C., Marchese N., Partesana N. G., Bandini P., Farinola G., Santoro D., Cassadonte F., Calabro F., Sansoni M., Abrignani M. G., Bonura F., Benvenuto M., Liso A., Passero T., Mori I., Pozzoni B., Prati F., Finocchiaro M. L., Tufano N., Miserrafiti B., Lacquaniti V., Del Piccolo F., Mohamad B., Spinnler M. T., Bovolo V., Rebulla E., Pieri M., Paloscia L., Di Clemente D., Mazzucco G., Micanti A., Peci P., Ornago O., Proietti F., Michisanti M., Reverzani A., Donatini A., Costa P., Russo S., Franceschini Grisolia E., Mario L., Di Palma F., Dell'Aquila F., Maestroni A., Caico S. I., De Caro G., Attianese L., Perotti S., Cotti Cometti V., Astengo D., Guerri E., Cianflone D., Maranta F., Esposito N., Malvezzi Caracciolo D'Aquino M., Caliendo L., Ricci C., Ceruso C. P., Lanteri S., Serdoz R., Bruno E., De Matteis C., Campagnuolo C., Ammirati M. A., Corrado V. M., Amado Eleas M. A., Fattore L., Ippoliti C., Turiano G., Piergentili C., Chiarella F., Capogrosso P., Perotti M., Di Marco S., Sibilio G., Di Lorenzo L., Aurelio A., Ramondo A. B., Zanna D., Cernetti C., Napolitano G., Negroni S., Alessandri N., Rigo F., Giusti F., Casu G., Vicentini A., Calculli G., Fera M. S., Lettica G. V., Vagheggini G., Piti A., Porfidia A., Di Leo A., Ravera A., Ciotta E., Sacca S., Silvestri O., Isidori S., Natali P., Anselmi M., Testa L., Antonelli A., Tavasci E., Furgi G., Lavorgna A., Gasparetto N., Bisceglia T., De Luca, L., Colivicchi, F., Meessen, J., Uguccioni, M., Piscione, F., Bernabo, P., Lardieri, G., Granatelli, A., Gabrielli, D., Gulizia, M. M., Silverio, A., Benvenga, R. M., Mascia, F., Fusco, A., Cicala, S., Oltrona Visconti, L., Marinoni, B., Canosi, U., Cirillo, P., Trimarco, B., Ziviello, F., Grosseto, D., Menozzi, M., Mezzena, D., Mauro, C., Sasso, A., Bellis, A., Calabro, P., Gragnano, F., Cesaro, A., Venturelli, V., Porretta, V., Borrelli, N., Indolfi, C., De Rosa, S., Torella, D., Morici, N., Molfese, M., Della Rovere, F., Caiffa, T., Moretto, G., Grippo, G., Di Vincenzo, E., Lucisano, L., Pennacchi, M., Geraci, G., Sanfilippo, N., Ledda, A., Di Lenarda, A., Cherubini, A., Russo, G., Piemonte, F., Di Donato, A., Carraturo, A., Villari, B., Ciampi, Q., Contaldi, C., Pacher, V., Corrada, E., Cattani, D., Nassiacos, D., Meloni, S., Barco, B., Bonmassari, R., Bertoldi, A., Tedoldi, F., Cannone, M., Valenti, G., Musci, R. L., Caldarola, P., Locuratolo, N., Sublimi Saponetti, L., Gentili, L., Maiandi, C., Caputo, M., Capparuccia, C. A., Tonella, T., Massari, F. M., Lupi, A., Tessitori, M., Montano, M., Scaglione, A., Torri, A., Tortorella, G., Navazio, A., Cemin, R., Latina, L., Briguglia, D., Marino, R., Scalvini, S., Zanelli, E., Paganini, V., Riboni, G., Leiballi, E., Della Mattia, A., Imperadore, F., Tespili, M., Santangelo, G., Parravicini, U., Dellavesa, P., Testa, R., Venturini, E., Feola, M., Testa, M., Crisci, V., Tramontana, M., Robiglio, L., Varbella, F., Meynet, I., Galati, A., Maddaluna, A., Bilato, C., Loddo, I., Licciardello, G., Cassaniti, L., Scherillo, M., Formigli, D., Marullo, L., Chianese, L., Paolillo, C., De Santis, A. P. A., Brunetti, N. D., Bottigliero, D., Della Bona, R., Giannico, M. B., Tramarin, R., Lucibello, S., Perna, G. P., Marini, M., Colavita, A. R., Francese, G. M., Mariani, M., Collauto, F., D'Urbano, M., Naio, R., Ando, G., Saporito, F., Assanelli, E. M., Cabiati, A., Crivaro, A., Alberti, S., Marchese, I., Nejat, T., Refice, S., Aiello, A., Cristinziani, G. R., Barilla, F., Iorio, R., Mascelli, G., Tartaglione, S. N., Di Chiara, G., D'Andrea, D., Antonicelli, R., Malatesta, G., Di Mario, C., Mattesini, A., Tramontana, L., Conti, S., Sommariva, L., Celestini, A., Amico, F., Giubilato, S., Amico, A. F., De Filippis, M., Pasini, G. F., Triggiani, M., Ferrara, V., Cappetti, S., Carugo, S., Lucreziotti, S., Persico, M., Gizzi, G., Cipolla, T., Caronia, A., Buia, E., Pastori, P., Scarpignato, M., Biscottini, E., Poletti, F., Vimercati, C., Pirola, R., Barbieri, E., Dugo, C., De Cesare, N., De Benedictis, M. L., Ruggeri, A., Campana, C., Bonura, S., Vigna, C., Marchese, N., Partesana, N. G., Bandini, P., Farinola, G., Santoro, D., Cassadonte, F., Calabro, F., Sansoni, M., Abrignani, M. G., Bonura, F., Benvenuto, M., Liso, A., Passero, T., Mori, I., Pozzoni, B., Prati, F., Finocchiaro, M. L., Tufano, N., Miserrafiti, B., Lacquaniti, V., Del Piccolo, F., Mohamad, B., Spinnler, M. T., Bovolo, V., Rebulla, E., Pieri, M., Paloscia, L., Di Clemente, D., Mazzucco, G., Micanti, A., Peci, P., Ornago, O., Proietti, F., Michisanti, M., Reverzani, A., Donatini, A., Costa, P., Russo, S., Franceschini Grisolia, E., Mario, L., Di Palma, F., Dell'Aquila, F., Maestroni, A., Caico, S. I., De Caro, G., Attianese, L., Perotti, S., Cotti Cometti, V., Astengo, D., Guerri, E., Cianflone, D., Maranta, F., Esposito, N., Malvezzi Caracciolo D'Aquino, M., Caliendo, L., Ricci, C., Ceruso, C. P., Lanteri, S., Serdoz, R., Bruno, E., De Matteis, C., Campagnuolo, C., Ammirati, M. A., Corrado, V. M., Amado Eleas, M. A., Fattore, L., Ippoliti, C., Turiano, G., Piergentili, C., Chiarella, F., Capogrosso, P., Perotti, M., Di Marco, S., Sibilio, G., Di Lorenzo, L., Aurelio, A., Ramondo, A. B., Zanna, D., Cernetti, C., Napolitano, G., Negroni, S., Alessandri, N., Rigo, F., Giusti, F., Casu, G., Vicentini, A., Calculli, G., Fera, M. S., Lettica, G. V., Vagheggini, G., Piti, A., Porfidia, A., Di Leo, A., Ravera, A., Ciotta, E., Sacca, S., Silvestri, O., Isidori, S., Natali, P., Anselmi, M., Testa, L., Antonelli, A., Tavasci, E., Furgi, G., Lavorgna, A., Gasparetto, N., Bisceglia, T., Raziliop, A., and Raino, R.

Subjects
Male, Multivariate analysis, Time Factors, medicine.medical_treatment, Myocardial Infarction, 030204 cardiovascular system & hematology, 0302 clinical medicine, Cardiologists, post‐MI, 030212 general & internal medicine, Myocardial infarction, Prospective Studies, Registries, intervention, risk, Dual Anti-Platelet Therapy, focused update, ticagrelor keywords plus:coronary-artery-disease, Atrial fibrillation, General Medicine, clopidogrel, dual antiplatelet therapy, percutaneous coronary intervention, post-mi, secondary prevention, dapt score, duration, management, Middle Aged, Clopidogrel, Treatment Outcome, Female, Cardiology and Cardiovascular Medicine, Ticagrelor, Human, medicine.drug, medicine.medical_specialty, animal structures, Time Factor, Clinical Investigations, Cardiologist, Drug Administration Schedule, Follow-Up Studie, ticagrelor, 03 medical and health sciences, Internal medicine, medicine, Humans, cardiovascular diseases, Aged, Aspirin, post-MI, Follow-Up Studies, Platelet Aggregation Inhibitors, Patient Selection, business.industry, Platelet Aggregation Inhibitor, Percutaneous coronary intervention, medicine.disease, Prospective Studie, Conventional PCI, Observational study, business
Abstract

Background Current guidelines suggest to consider dual antiplatelet therapy (DAPT) continuation for longer than 12 months in selected patients with myocardial infarction (MI). Hypothesis We sought to assess the criteria used by cardiologists in daily practice to select patients with a history of MI eligible for DAPT continuation beyond 1 year. Methods We analyzed data from the EYESHOT Post-MI, a prospective, observational, nationwide study aimed to evaluate the management of patients presenting to cardiologists 1 to 3 years from the last MI event. Results Out of the 1633 post-MI patients enrolled in the study between March and December 2017, 557 (34.1%) were on DAPT at the time of enrolment, and 450 (27.6%) were prescribed DAPT after cardiologist assessment. At multivariate analyses, a percutaneous coronary intervention (PCI) with multiple stents and the presence of peripheral artery disease (PAD) resulted as independent predictors of DAPT continuation, while atrial fibrillation was the only independent predictor of DAPT interruption for patients both at the second and the third year from MI at enrolment and the time of discharge/end of the visit. Conclusions Risk scores recommended by current guidelines for guiding decisions on DAPT duration are underused and misused in clinical practice. A PCI with multiple stents and a history of PAD resulted as the clinical variables more frequently associated with DAPT continuation beyond 1 year from the index MI.

Published
2019

15. Treatment of chronic venous insufficiency and prevention of economy class syndrome.

Author

Belcaro, G., primary, Cesarone, M. R., additional, Cornelli, U., additional, Rohdewald, P., additional, Ledda, A., additional, Renzo, A. di, additional, Stuard, S., additional, Cacchio, M., additional, Vinciguerra, G., additional, Gizzi, G., additional, Pellegrini, L., additional, Dugall, M., additional, Ricci, A., additional, Ruffini, I., additional, and Fano, F., additional

Published
2008
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17. Management of Superficial Vein Thrombosis and Thrombophlebitis: Status and Expert Opinion Document

Author

Cesarone, M. R., Belcaro, G., Agus, G., Georgiev, M., Errichi, B. M., Marinucci, R., Errichi, S., Filippini, A., Pellegrini, L., Ledda, A., Vinciguerra, G., Ricci, A., Cipollone, G., Lania, M., Gizzi, G., Ippolito, E., Bavera, P., Fano, F., Dugall, M., Adovasio, R., Gallione, L., Del Boccio, G., Cornelli, U., Steigerwalt, R., Acerbi, G., Cacchio, M., Di Renzo, A., Hosoi, M., Stuard, S., Corsi, M., Di Ciano, L., Simeone, E., Collevecchio, G., Grossi, M. G., Di Giambattista, F., Carestia, F., and Zukowski, A.

Published
2007

18. Topical Heparin: New Observations

Author

Cesarone, M. R., Belcaro, G., Errichi, S., Cornelli, U., Pellegrini, L., Ruffini, I., Errichi, B. M., Ledda, A., Vinciguerra, G., Ricci, A., Gizzi, G., Ippolito, E., Fano, F., Dugall, M., Cacchio, M., Di Renzo, A., Hosoi, M., Grossi, M. G., Stuard, S., and Corsi, M.

Published
2007

31. Implementation of EMS Applications in a Subtransmission System.

Author

Rosés, R. E., Cartestia, D. R., and Gizzi, G. F.

Subjects
CONTROL rooms, SUPERVISORY control & data acquisition systems, TASK analysis, WAREHOUSES
Abstract

Copyright of Revista Técnica Energía is the property of Centro Nacional de Control de Energia CENACE and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2020

33. Managing ulcerative colitis in remission phase: usefulness of Casperome®, an innovative lecithin-based delivery system of Boswellia serrata extract

Author

Pellegrini, L., Milano, E., Franceschi, F., Belcaro, G., Gizzi, G., Feragalli, B., Dugall, M., Luzzi, R., Togni, S., Roberto Eggenhoffner, and Giacomelli, L.

Subjects
Drug Delivery Systems, Plant Extracts, Lecithins, Remission Induction, Colitis, Ulcerative, Humans, Boswellia, Ulcerative, Colitis
Abstract

Boswellia serrata extracts (BSE) have been traditionally used for the treatment of several inflammatory diseases. The aim of this study was to evaluate the efficacy of a novel delivery form of BSE (Casperome®) in Ulcerative Colitis (UC) during minimally symptomatic remission phase.In this open-label, observational, registry study, informed participants with UC in remission phase (n = 43) freely decided to receive the oral daily Casperome® supplementation (n = 22) or no supplementation (n = 21) for 4 weeks. Several parameters associated with minimally symptomatic UC in remission were evaluated at the inclusion and the end of the study.A significant beneficial effect of Casperome® was observed for all the parameters evaluated, namely: diffuse intestinal pain, evident and occult blood in stools, bowel movements and cramps, watery stools, malaise, anemia, rectal involvement, number of white blood cells as well as need for concomitant drugs and medical attention. Faecal concentration of calprotectin, a marker of bowel inflammation, resulted ameliorated in Casperome® supplemented patients.Our study showed that Casperome® supplementation attenuates symptoms associated with mild UC in remission, reducing the use of drugs and medical consultations. Therefore, our study suggests that Casperome® supplementation could represent a promising alternative approach to manage minimally symptomatic UC and maintain the remission phase.

Published
2016

34. Prevalence of nonpolypoid colorectal neoplasia: an italian multicenter observational study

Author

Bianco, Ma, Cipolletta, L, Rotondano, G, Buffoli, F, Gizzi, G, Tessari, F, Crotta, S, Strini, G, Orsello, M, Ballare, M, Gallo, M, Salacone, P, Asnaghi, G, Manca, A, Rizzi, R, Predebon, S, Quattrone, P, Vanni, R, Di Placido, R, Bastardini, R, Cristoni, Mv, Praiano, F, Meroni, E, Fasoli, A, Coccia, G, Allegretti, A, Manes, G, Cesari, P, Rolfi, F, Zambelli, A, Manfredi, G, Lisi, S, Cestari, R, Lancini, Gp, Crosta, C, Fiori, G, De Roberto, G, Dal Fante, M, Fazzini, L, Dinelli, M, Frego, R, Parente, F, Bargiggia, S, Paggi, S, Viale, E, Testoni, Pa, Iiritano, E, Andrian, G, Dinca, M, Germana, B, Lecis, P, Cappiello, R, Sablich, R, Tonello, C, Buri, L, Cannizzaro, R, Maiero, S, Fasoli, R, Ceroni, L, Eusebi, Lh, Iori, V, Tioli, C, Villani, V, Cortini, C, Maltoni, S, Forti, E, Solmi, L, Giovanardi, M, Calella, F, Tarantino, O, Widmayer, C, Silvestrelli, M, Bou Serhal, T, Feliciangeli, G, Tombesi, G, Anti, M, Pastorelli, A, Costamagna, G, Petruzziello, L, Cesaro, P, De Masi, E, Errico, A, Di Giulio, E, Carnuccio, A, Gabbrielli, Armando, Pandolfi, M, Lamazza, A, Femia, S, Morini, S, Lorenzetti, R, Del Vecchio Blanco, G, Grasso, E, Ferrara, M, Apuzzo, M, Iacopini, F, Milano, A, Balatsinou, C, Spadaccini, A, Silla, M, Ingrosso, M, Pirozzi, Ga, De Luca, L, De Bellis, M, Tempesta, A, De Palma GD, Siciliano, S, Di Giorgio, P, Giannattasio, F, Galloro, G, Grimaldi, E, Ciarleglio, A, Sarrantonio, G, Delle Cave, M, Lamanda, R, De Stefano, S, Labianca, O, Maisto, T, Montanaro, F, Pasquale, L, Di Girolamo, E, Piscopo, R, De Seta, M, Romano, M, Borgheresi, P, Gravina, Ag, Sarracco, P, Scaglione, G, Marmo, R, Salerno, R, Gentile, M, Annese, V, Della Valle, N, Muscatiello, N, Di Matteo, G, Giorgio, P, Fregola, G, Quatraro, F, Pisani, A, Tonti, P, Stoppino, G, Corazza, L, D'Ascoli, B, Ciuffi, M, Ignomirelli, O, Giglio, A, Rodino, S, Scanu, Am, Loriga, P, Murgia, R, Giacobbe, G, Grande, D, Montalbano, L, Linea, C., Bianco, Ma, Cipolletta, L, Rotondano, G, Buffoli, F, Gizzi, G, Tessari, F, Testoni, PIER ALBERTO, Flat Lesions Italian, Network, DE PALMA, GIOVANNI DOMENICO, Ma, Bianco, L., Cipolletta, G., Rotondano, F., Buffoli, G., Gizzi, F., Tessari, Romano, Marco, Gravina, A. G., Maria Antonia, Bianco, Livio, Cipolletta, Gianluca, Rotondano, Federico, Buffoli, Giuseppe, Gizzi, Francesco, Tessari, and Galloro, Giuseppe

Subjects
Male, medicine.medical_specialty, Colorectal cancer, Prevalence, Colonic Polyps, Colonoscopy, Colorectal Neoplasm, colonoscopy, flat lesions, colorectal neoplasia, Gastroenterology, Internal medicine, Epidemiology, medicine, Humans, Prospective Studies, Aged, Intraepithelial neoplasia, medicine.diagnostic_test, business.industry, Cancer, Histology, Middle Aged, medicine.disease, Colonic Polyp, Prospective Studie, Italy, Observational study, Female, Colorectal Neoplasms, business, Human
Abstract

BACKGROUND AND STUDY AIM: The aim of this study was to assess the prevalence of nonpolypoid lesions (NPLs) in Italy and their risk of containing neoplasia or advanced histology. PATIENTS AND METHODS: This was a multicenter cross-sectional observational study on consecutive patients undergoing total colonoscopy over a 3-month period in 80 Italian centers. RESULTS: In all, 27,400 total colonoscopies were analyzed. Cancer was diagnosed in 801 patients (2.9 %). A total of 6553 precancerous lesions were detected in 5609 patients. Of these, 4154 patients (74.1 %) had polypoid lesions and 1455 patients (25.9 %) had NPLs. Therefore, the prevalence of NPLs was 5.3 % (95 %CI 5.0 - 5.6). NPLs larger than 10 mm were detected in 254 patients (17.5 %). NPLs were more predominant in the proximal colon (OR 2.92, 95 %CI 2.56 - 3.43; P < 0.0001 vs. polypoid lesions). Neoplastic tissue was diagnosed in 79.0 % and advanced histology (high-grade intraepithelial neoplasia or more) in 20.9 % of resected lesions. The risk of advanced histology was similar for polypoid and nonpolypoid lesions when adjusted for size. Depressed lesions had the highest risk of advanced histology (OR 10.56, 95 %CI 6.02 - 18.55; P < 0.0000 vs. flat-elevated). Age was an independent predictor of both neoplasia and advanced histology ( P = 0.0001). CONCLUSIONS: NPLs are relatively common in the Italian population, with a prevalence similar to that in other Western series. NPLs are not more aggressive than polypoid lesions, except for those with depressed morphology. Georg Thieme Verlag KG Stuttgart. New York.

Published
2010

35. Clinical Cases: HIT session - Top of the hub: best clinical cases852A rare cause of severe chest pain and sustained ventricular tachycardia during a football game853Thrombosed iliac venous aneurysm as a extremely rare source of pulmonary thromboembolism8543D transesophageal echo: guide to anticoagulation therapy after surgical closure of the left atrial appendage855A unusual case of giant coronary aneurysm: role of multimodality imaging in the diagnosis and follow-up858Myocardial cleft in a patient with acute coronary syndrome assessed by multimodal imaging859A rare case of subacute left atrial dissection860A case of pulmonary sarcoidosis with severe precapillary pulmonary hypertension and extrinsic compression of the pulmonary artery

Author

Arzanauskaite, M., primary, Bereda, J., primary, Cecchetto, A., primary, Casadei, F., primary, Lorenzo, N., primary, Gizzi, G., primary, Huitema, MP., primary, Baksi, AJ., additional, Mohiaddin, RH., additional, Grodecki, Ł, additional, Chiampan, A., additional, Bonapace, S., additional, Albrigi, L., additional, Adamo, E., additional, Lanzoni, L., additional, Barbieri, E., additional, Quattrocchi, S., additional, Moreo, A., additional, Ammirati, E., additional, Musca, F., additional, Artioli, D., additional, De Chiara, B., additional, Vigano', E., additional, Cereda, A., additional, Giannattasio, C., additional, Rodriguez, AM., additional, Bartolome, S., additional, Darriba, MJ., additional, Berzal, B., additional, Perez, E., additional, Galan, L., additional, Gonzalez, R., additional, Lavorgna, A., additional, Fabiani, D., additional, Restauri, L., additional, Villani, C., additional, Di Eusanio, M., additional, Napoletano, C., additional, Grutters, JC., additional, Van Es, HW., additional, Bakker, AL., additional, and Post, MC., additional

Published
2016
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36. Noninvasive Investigations in Vascular Disease

Author

Belcaro, G., Incandela, L., Martin Veller, Labropoulos, N., Nicolaides, A. N., Laurora, G., Cesarone, M. R., Leon, M., Christopoulos, D., Malouf, M., Desanctis, M. T., Myers, K., Dhanjil, S., Ramaswami, G., Geroulakos, G., Szendro, G., Griffin, M., Vasdekis, S., Fisher, C., Venniker, R., Helmis, E., Pellegrini, L., Gizzi, G., Ricci, A., Tegos, T., Sabetai, M., Lennox, A., and Fernandes E Fernandes, J.

Subjects
medicine.medical_specialty, Vascular disease, business.industry, 030204 cardiovascular system & hematology, medicine.disease, Renal artery stenosis, Peripheral, 03 medical and health sciences, INTESTINAL ISCHAEMIA, 0302 clinical medicine, medicine, cardiovascular diseases, 030212 general & internal medicine, Radiology, Cardiology and Cardiovascular Medicine, business
Abstract

Tests for peripheral vascular diseases tests for cerebrovascular diseases renal artery stenosis intestinal ischaemia aneurysms venous diseases other vascular problems, malformations and tumours surveillance vascular screening other applications of noninvasive vascular investigations other nonvascular applications points to consider in noninvasive investigations.

Published
1998
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43. Endoscopic resection for superficial colorectal neoplasia in Italy: a prospective multicentre study

Author

Cipolletta, L, Rotondano, G, Bianco, Ma, Buffoli, F, Gizzi, G, Tessari, F, Ingrosso, Marcello, Ingrosso, Marcello (ORCID:0000-0003-3550-6557), Cipolletta, L, Rotondano, G, Bianco, Ma, Buffoli, F, Gizzi, G, Tessari, F, Ingrosso, Marcello, and Ingrosso, Marcello (ORCID:0000-0003-3550-6557)

Abstract

Since there are few prospective studies on colorectal endoscopic resection to date, we aimed to prospectively assess safety and efficacy of endoscopic resection in a cohort of Italian patients.

Published
2014

44. Pycnogenol® may alleviate adverse effects in oncologic treatment

Author

Belcaro, G., Cesarone, M. R., Genovesi, D., Ledda, A., Vinciguerra, G., Ricci, A., Pellegrini, L., Gizzi, G., Ippolito, E., Dugall, M., Cacchio, M., Direnzo, A., and Stuard, S.

Subjects
Radiotherapy drug therapy, Medicine (all), Thrombosis
Published
2008

45. Supplementation with a lecithin-based delivery form of Boswellia serrata extract (Casperome®) controls symptoms of mild irritable bowel syndrome.

Author

BELCARO, G., GIZZI, G., PELLEGRINI, L., CORSI, M., DUGALL, M., CACCHIO, M., FERAGALLI, B., TOGNI, S., RIVA, A., EGGENHOFFNER, R., and GIACOMELLI, L.

Abstract

OBJECTIVE: Irritable Bowel Syndrome (IBS) is a chronic, gastrointestinal disorder in which abdominal pain or discomfort is associated with defecation or changes in bowel habits. Its multifactorial pathophysiology leads to a variety of available treatments, mainly aimed at controlling symptoms. The management of IBS patients could be optimized by individualized strategies, including non-pharmaceutical approaches. In this study, we evaluated the efficacy and safety of a novel delivery form of Boswellia serrata extracts (BSE) (Casperome ®) in patients with IBS. PATIENTS AND METHODS: 71 otherwise healthy subjects with idiopathic IBS were recruited. Participants were assigned to the following management strategies: hyoscine butylbromide; papaverine hydrochloride + A. belladonna extract; supplementation with Casperome ®. Predominant IBS symptoms were evaluated at inclusion and at the end of the observational period (4 weeks). The numbers of subjects who needed rescue medication or medical attention/hospital admission were recorded. Adverse events were also evaluated. RESULTS: In all groups, the IBS symptoms investigated, namely abdominal pain, altered bowel movements, meteorism and cramps improved during the observational period. Of note, the number of subjects who needed medical attention significantly decreased only in Casperome ®-supplemented group. In addition, Casperome ® supplementation was related to a lower incidence of side effects (mainly stypsis). CONCLUSIONS: This preliminary study suggests that Casperome® supplementation could represent a promising alternative approach to manage symptoms associated with IBS in otherwise healthy subjects. [ABSTRACT FROM AUTHOR]

Published
2017

48. Managing ulcerative colitis in remission phase: usefulness of Casperome®, an innovative lecithin-based delivery system of Boswellia serrata extract.

Author

PELLEGRINI, L., MILANO, E., FRANCESCHI, F., BELCARO, G., GIZZI, G., FERAGALLI, B., DUGALL, M., LUZZI, R., TOGNI, S., EGGENHOFFNER, R., and GIACOMELLI, L.

Abstract

OBJECTIVE: Boswellia serrata extracts (BSE) have been traditionally used for the treatment of several inflammatory diseases. The aim of this study was to evaluate the efficacy of a novel delivery form of BSE (Casperome®) in Ulcerative Colitis (UC) during minimally symptomatic remission phase. PATIENTS AND METHODS: In this open-label, observational, registry study, informed participants with UC in remission phase (n = 43) freely decided to receive the oral daily Casperome® supplementation (n = 22) or no supplementation (n = 21) for 4 weeks. Several parameters associated with minimally symptomatic UC in remission were evaluated at the inclusion and the end of the study. RESULTS: A significant beneficial effect of Casperome® was observed for all the parameters evaluated, namely: diffuse intestinal pain, evident and occult blood in stools, bowel movements and cramps, watery stools, malaise, anemia, rectal involvement, number of white blood cells as well as need for concomitant drugs and medical attention. Faecal concentration of calprotectin, a marker of bowel inflammation, resulted ameliorated in Casperome® supplemented patients. CONCLUSIONS: Our study showed that Casperome® supplementation attenuates symptoms associated with mild UC in remission, reducing the use of drugs and medical consultations. Therefore, our study suggests that Casperome® supplementation could represent a promising alternative approach to manage minimally symptomatic UC and maintain the remission phase. [ABSTRACT FROM AUTHOR]

Published
2016

49. Bilberry extracts are not created equal: the role of non anthocyanin fraction. Discovering the “dark side of the force” in a preliminary study.

Author

GIZZI, C., BELCARO, G., GIZZI, G., FERAGALLI, B., DUGALL, M., LUZZI, R., and CORNELLI, U.

Abstract

OBJECTIVE: Several experimental studies and clinical trials support the potential of bilberry (Vaccinium myrtillus L) extracts in promoting eye health and circulation. Many active ingredients have been isolated from the berries and leaves of the bilberry plant. However, anthocyanins represent the most widely studied bioactive compounds in this plant. PATIENTS AND METHODS: The aim of this registry, supplement study was to evaluate the effects of Mirtoselect® (standardized in 36% anthocyanins and obtained by an industrial extraction process that preserves the full range of the non-anthocyanin components, mainly natural sugars and polyphenols) in different types of retinal vasculopathies. In total, 140 patients with different types of retinopathy spontaneously decided to join one of the following groups: standard management (SM) only (n=38); SM associated with Mirtoselect® supplementation (n=47); SM associated with a generic bilberry extract supplementation (n=55). Retinal circulatory parameters and flow measurements of the retinal vessels were evaluated at the inclusion and after 6-months supplementation. RESULTS: Overall, significant improvements in several retinal circulatory parameters such as retinal blood flow velocity, with respect to the values at inclusion, were observed in both supplementation groups, especially in Mirtoselect® supplementation group. However, at 6 months, inter-group comparison revealed a statistical advantage in all tested parameters for Mirtoselect® supplementation groups. No side effects or tolerability concerns were reported. CONCLUSIONS: Our registry study suggests that Mirtoselect® supplementation could represent an effective and safe integrated approach for the treatment of different retinopathies. [ABSTRACT FROM AUTHOR]

Published
2016

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