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Your search keyword '"Gladson, Candece L."' showing total 289 results
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289 results on '"Gladson, Candece L."'

1. Tissue factor is a critical regulator of radiation therapy-induced glioblastoma remodeling

Author

Jeon, Hye-Min, Kim, Jeong-Yub, Cho, Hee Jin, Lee, Won Jun, Nguyen, Dayna, Kim, Sung Soo, Oh, Young Taek, Kim, Hee-Jin, Jung, Chan-Woong, Pinero, Gonzalo, Joshi, Tanvi, Hambardzumyan, Dolores, Sakaguchi, Takuya, Hubert, Christopher G., McIntyre, Thomas M., Fine, Howard A., Gladson, Candece L., Wang, Bingcheng, Purow, Benjamin W., Park, Jong Bae, Park, Myung Jin, Nam, Do-Hyun, and Lee, Jeongwu

Published
2023
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3. Urokinase-type Plasminogen Activator Receptor (uPAR) Ligation Induces a Raft-localized Integrin Signaling Switch That Mediates the Hypermotile Phenotype of Fibrotic Fibroblasts*

Author

Grove, Lisa M, Southern, Brian D, Jin, Tong H, White, Kimberly E, Paruchuri, Sailaja, Harel, Efrat, Wei, Ying, Rahaman, O, Gladson, Candece L, Ding, Qiang, Craik, Charles S, Chapman, Harold A, and Olman, Mitchell A

Subjects
Biochemistry and Cell Biology, Biological Sciences, Rare Diseases, Lung, Autoimmune Disease, 2.1 Biological and endogenous factors, Aetiology, Respiratory, Animals, Blotting, Western, Caveolins, Cell Movement, Cells, Cultured, Fibroblasts, Fibronectins, Humans, Idiopathic Pulmonary Fibrosis, Integrin alpha5beta1, Membrane Microdomains, Mice, Microscopy, Fluorescence, Protein Binding, Proto-Oncogene Proteins c-fyn, RNA Interference, Receptors, Urokinase Plasminogen Activator, Severity of Illness Index, Shc Signaling Adaptor Proteins, Signal Transduction, Urokinase-Type Plasminogen Activator, Fibroblast, Fibrosis, Integrin, Lipid Raft, Urokinase Receptor, Chemical Sciences, Medical and Health Sciences, Biochemistry & Molecular Biology, Biological sciences, Biomedical and clinical sciences, Chemical sciences
Abstract

The urokinase-type plasminogen activator receptor (uPAR) is a glycosylphosphatidylinositol-linked membrane protein with no cytosolic domain that localizes to lipid raft microdomains. Our laboratory and others have documented that lung fibroblasts from patients with idiopathic pulmonary fibrosis (IPF) exhibit a hypermotile phenotype. This study was undertaken to elucidate the molecular mechanism whereby uPAR ligation with its cognate ligand, urokinase, induces a motile phenotype in human lung fibroblasts. We found that uPAR ligation with the urokinase receptor binding domain (amino-terminal fragment) leads to enhanced migration of fibroblasts on fibronectin in a protease-independent, lipid raft-dependent manner. Ligation of uPAR with the amino-terminal fragment recruited α5β1 integrin and the acylated form of the Src family kinase, Fyn, to lipid rafts. The biological consequences of this translocation were an increase in fibroblast motility and a switch of the integrin-initiated signal pathway for migration away from the lipid raft-independent focal adhesion kinase pathway and toward a lipid raft-dependent caveolin-Fyn-Shc pathway. Furthermore, an integrin homologous peptide as well as an antibody that competes with β1 for uPAR binding have the ability to block this effect. In addition, its relative insensitivity to cholesterol depletion suggests that the interactions of α5β1 integrin and uPAR drive the translocation of α5β1 integrin-acylated Fyn signaling complexes into lipid rafts upon uPAR ligation through protein-protein interactions. This signal switch is a novel pathway leading to the hypermotile phenotype of IPF patient-derived fibroblasts, seen with uPAR ligation. This uPAR dependent, fibrotic matrix-selective, and profibrotic fibroblast phenotype may be amenable to targeted therapeutics designed to ameliorate IPF.

Published
2014

4. Expression of LC3B and FIP200/Atg17 in brain metastases of breast cancer

Author

Hashemi-Sadraei, Nooshin, Müller-Greven, Gaëlle M., Abdul-Karim, Fadi W., Ulasov, Ilya, Downs-Kelly, Erinn, Burgett, Monica E., Lauko, Adam, Qadan, Maha A., Weil, Robert J., Ahluwalia, Manmeet S., Du, Lingling, Prayson, Richard A., Chao, Samuel T., Budd, Thomas G., Barnholtz-Sloan, Jill, Nowacki, Amy S., Keri, Ruth A., and Gladson, Candece L.

Published
2018
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5. Supplemental Methods from Macropinocytosis of Bevacizumab by Glioblastoma Cells in the Perivascular Niche Affects their Survival

Author

Müller-Greven, Gaëlle, primary, Carlin, Cathleen R., primary, Burgett, Monica E., primary, Ahluwalia, Manmeet S., primary, Lauko, Adam, primary, Nowacki, Amy S., primary, Herting, Cameron J., primary, Qadan, Maha A., primary, Bredel, Markus, primary, Toms, Steven A., primary, Lathia, Justin D., primary, Hambardzumyan, Dolores, primary, Sarkaria, Jann N., primary, Hamerlik, Petra, primary, and Gladson, Candece L., primary

Published
2023
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6. SFigure 5 from Macropinocytosis of Bevacizumab by Glioblastoma Cells in the Perivascular Niche Affects their Survival

Author

Müller-Greven, Gaëlle, primary, Carlin, Cathleen R., primary, Burgett, Monica E., primary, Ahluwalia, Manmeet S., primary, Lauko, Adam, primary, Nowacki, Amy S., primary, Herting, Cameron J., primary, Qadan, Maha A., primary, Bredel, Markus, primary, Toms, Steven A., primary, Lathia, Justin D., primary, Hambardzumyan, Dolores, primary, Sarkaria, Jann N., primary, Hamerlik, Petra, primary, and Gladson, Candece L., primary

Published
2023
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7. SFigure 6 from Macropinocytosis of Bevacizumab by Glioblastoma Cells in the Perivascular Niche Affects their Survival

Author

Müller-Greven, Gaëlle, primary, Carlin, Cathleen R., primary, Burgett, Monica E., primary, Ahluwalia, Manmeet S., primary, Lauko, Adam, primary, Nowacki, Amy S., primary, Herting, Cameron J., primary, Qadan, Maha A., primary, Bredel, Markus, primary, Toms, Steven A., primary, Lathia, Justin D., primary, Hambardzumyan, Dolores, primary, Sarkaria, Jann N., primary, Hamerlik, Petra, primary, and Gladson, Candece L., primary

Published
2023
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8. SFigure 1 from Macropinocytosis of Bevacizumab by Glioblastoma Cells in the Perivascular Niche Affects their Survival

Author

Müller-Greven, Gaëlle, primary, Carlin, Cathleen R., primary, Burgett, Monica E., primary, Ahluwalia, Manmeet S., primary, Lauko, Adam, primary, Nowacki, Amy S., primary, Herting, Cameron J., primary, Qadan, Maha A., primary, Bredel, Markus, primary, Toms, Steven A., primary, Lathia, Justin D., primary, Hambardzumyan, Dolores, primary, Sarkaria, Jann N., primary, Hamerlik, Petra, primary, and Gladson, Candece L., primary

Published
2023
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9. SFigure 7 from Macropinocytosis of Bevacizumab by Glioblastoma Cells in the Perivascular Niche Affects their Survival

Author

Müller-Greven, Gaëlle, primary, Carlin, Cathleen R., primary, Burgett, Monica E., primary, Ahluwalia, Manmeet S., primary, Lauko, Adam, primary, Nowacki, Amy S., primary, Herting, Cameron J., primary, Qadan, Maha A., primary, Bredel, Markus, primary, Toms, Steven A., primary, Lathia, Justin D., primary, Hambardzumyan, Dolores, primary, Sarkaria, Jann N., primary, Hamerlik, Petra, primary, and Gladson, Candece L., primary

Published
2023
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10. SFigure 4 from Macropinocytosis of Bevacizumab by Glioblastoma Cells in the Perivascular Niche Affects their Survival

Author

Müller-Greven, Gaëlle, primary, Carlin, Cathleen R., primary, Burgett, Monica E., primary, Ahluwalia, Manmeet S., primary, Lauko, Adam, primary, Nowacki, Amy S., primary, Herting, Cameron J., primary, Qadan, Maha A., primary, Bredel, Markus, primary, Toms, Steven A., primary, Lathia, Justin D., primary, Hambardzumyan, Dolores, primary, Sarkaria, Jann N., primary, Hamerlik, Petra, primary, and Gladson, Candece L., primary

Published
2023
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11. SFigure 3 from Macropinocytosis of Bevacizumab by Glioblastoma Cells in the Perivascular Niche Affects their Survival

Author

Müller-Greven, Gaëlle, primary, Carlin, Cathleen R., primary, Burgett, Monica E., primary, Ahluwalia, Manmeet S., primary, Lauko, Adam, primary, Nowacki, Amy S., primary, Herting, Cameron J., primary, Qadan, Maha A., primary, Bredel, Markus, primary, Toms, Steven A., primary, Lathia, Justin D., primary, Hambardzumyan, Dolores, primary, Sarkaria, Jann N., primary, Hamerlik, Petra, primary, and Gladson, Candece L., primary

Published
2023
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12. SFigure 2 from Macropinocytosis of Bevacizumab by Glioblastoma Cells in the Perivascular Niche Affects their Survival

Author

Müller-Greven, Gaëlle, primary, Carlin, Cathleen R., primary, Burgett, Monica E., primary, Ahluwalia, Manmeet S., primary, Lauko, Adam, primary, Nowacki, Amy S., primary, Herting, Cameron J., primary, Qadan, Maha A., primary, Bredel, Markus, primary, Toms, Steven A., primary, Lathia, Justin D., primary, Hambardzumyan, Dolores, primary, Sarkaria, Jann N., primary, Hamerlik, Petra, primary, and Gladson, Candece L., primary

Published
2023
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13. Supplementary Figure 4 from Endothelial Expression of TNF Receptor-1 Generates a Proapoptotic Signal Inhibited by Integrin α6β1 in Glioblastoma

Author

Huang, Ping, primary, Rani, M.R. Sandhya, primary, Ahluwalia, Manmeet S., primary, Bae, Eunnyung, primary, Prayson, Richard A., primary, Weil, Robert J., primary, Nowacki, Amy S., primary, Hedayat, Hirad, primary, Sloan, Andrew E., primary, Lathia, Justin D., primary, Rich, Jeremy N., primary, Tipps, Russell, primary, and Gladson, Candece L., primary

Published
2023
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14. Supplementary Figure Legends 1-7 from Endothelial Expression of TNF Receptor-1 Generates a Proapoptotic Signal Inhibited by Integrin α6β1 in Glioblastoma

Author

Huang, Ping, primary, Rani, M.R. Sandhya, primary, Ahluwalia, Manmeet S., primary, Bae, Eunnyung, primary, Prayson, Richard A., primary, Weil, Robert J., primary, Nowacki, Amy S., primary, Hedayat, Hirad, primary, Sloan, Andrew E., primary, Lathia, Justin D., primary, Rich, Jeremy N., primary, Tipps, Russell, primary, and Gladson, Candece L., primary

Published
2023
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15. Supplementary Figure 1 from Endothelial Expression of TNF Receptor-1 Generates a Proapoptotic Signal Inhibited by Integrin α6β1 in Glioblastoma

Author

Huang, Ping, primary, Rani, M.R. Sandhya, primary, Ahluwalia, Manmeet S., primary, Bae, Eunnyung, primary, Prayson, Richard A., primary, Weil, Robert J., primary, Nowacki, Amy S., primary, Hedayat, Hirad, primary, Sloan, Andrew E., primary, Lathia, Justin D., primary, Rich, Jeremy N., primary, Tipps, Russell, primary, and Gladson, Candece L., primary

Published
2023
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16. Supplementary Figure 5 from Endothelial Expression of TNF Receptor-1 Generates a Proapoptotic Signal Inhibited by Integrin α6β1 in Glioblastoma

Author

Huang, Ping, primary, Rani, M.R. Sandhya, primary, Ahluwalia, Manmeet S., primary, Bae, Eunnyung, primary, Prayson, Richard A., primary, Weil, Robert J., primary, Nowacki, Amy S., primary, Hedayat, Hirad, primary, Sloan, Andrew E., primary, Lathia, Justin D., primary, Rich, Jeremy N., primary, Tipps, Russell, primary, and Gladson, Candece L., primary

Published
2023
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17. Data from Endothelial Expression of TNF Receptor-1 Generates a Proapoptotic Signal Inhibited by Integrin α6β1 in Glioblastoma

Author

Huang, Ping, primary, Rani, M.R. Sandhya, primary, Ahluwalia, Manmeet S., primary, Bae, Eunnyung, primary, Prayson, Richard A., primary, Weil, Robert J., primary, Nowacki, Amy S., primary, Hedayat, Hirad, primary, Sloan, Andrew E., primary, Lathia, Justin D., primary, Rich, Jeremy N., primary, Tipps, Russell, primary, and Gladson, Candece L., primary

Published
2023
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19. Supplementary Figure 2 from Endothelial Expression of TNF Receptor-1 Generates a Proapoptotic Signal Inhibited by Integrin α6β1 in Glioblastoma

Author

Huang, Ping, primary, Rani, M.R. Sandhya, primary, Ahluwalia, Manmeet S., primary, Bae, Eunnyung, primary, Prayson, Richard A., primary, Weil, Robert J., primary, Nowacki, Amy S., primary, Hedayat, Hirad, primary, Sloan, Andrew E., primary, Lathia, Justin D., primary, Rich, Jeremy N., primary, Tipps, Russell, primary, and Gladson, Candece L., primary

Published
2023
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20. Supplementary Table 2 from Endothelial Expression of TNF Receptor-1 Generates a Proapoptotic Signal Inhibited by Integrin α6β1 in Glioblastoma

Author

Huang, Ping, primary, Rani, M.R. Sandhya, primary, Ahluwalia, Manmeet S., primary, Bae, Eunnyung, primary, Prayson, Richard A., primary, Weil, Robert J., primary, Nowacki, Amy S., primary, Hedayat, Hirad, primary, Sloan, Andrew E., primary, Lathia, Justin D., primary, Rich, Jeremy N., primary, Tipps, Russell, primary, and Gladson, Candece L., primary

Published
2023
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21. Supplementary Figure 3 from Endothelial Expression of TNF Receptor-1 Generates a Proapoptotic Signal Inhibited by Integrin α6β1 in Glioblastoma

Author

Huang, Ping, primary, Rani, M.R. Sandhya, primary, Ahluwalia, Manmeet S., primary, Bae, Eunnyung, primary, Prayson, Richard A., primary, Weil, Robert J., primary, Nowacki, Amy S., primary, Hedayat, Hirad, primary, Sloan, Andrew E., primary, Lathia, Justin D., primary, Rich, Jeremy N., primary, Tipps, Russell, primary, and Gladson, Candece L., primary

Published
2023
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24. Supplementary Figure 6 from Endothelial Expression of TNF Receptor-1 Generates a Proapoptotic Signal Inhibited by Integrin α6β1 in Glioblastoma

Author

Huang, Ping, primary, Rani, M.R. Sandhya, primary, Ahluwalia, Manmeet S., primary, Bae, Eunnyung, primary, Prayson, Richard A., primary, Weil, Robert J., primary, Nowacki, Amy S., primary, Hedayat, Hirad, primary, Sloan, Andrew E., primary, Lathia, Justin D., primary, Rich, Jeremy N., primary, Tipps, Russell, primary, and Gladson, Candece L., primary

Published
2023
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27. Supplementary Table 1 from Endothelial Expression of TNF Receptor-1 Generates a Proapoptotic Signal Inhibited by Integrin α6β1 in Glioblastoma

Author

Huang, Ping, primary, Rani, M.R. Sandhya, primary, Ahluwalia, Manmeet S., primary, Bae, Eunnyung, primary, Prayson, Richard A., primary, Weil, Robert J., primary, Nowacki, Amy S., primary, Hedayat, Hirad, primary, Sloan, Andrew E., primary, Lathia, Justin D., primary, Rich, Jeremy N., primary, Tipps, Russell, primary, and Gladson, Candece L., primary

Published
2023
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28. Supplementary Figure 7 from Endothelial Expression of TNF Receptor-1 Generates a Proapoptotic Signal Inhibited by Integrin α6β1 in Glioblastoma

Author

Huang, Ping, primary, Rani, M.R. Sandhya, primary, Ahluwalia, Manmeet S., primary, Bae, Eunnyung, primary, Prayson, Richard A., primary, Weil, Robert J., primary, Nowacki, Amy S., primary, Hedayat, Hirad, primary, Sloan, Andrew E., primary, Lathia, Justin D., primary, Rich, Jeremy N., primary, Tipps, Russell, primary, and Gladson, Candece L., primary

Published
2023
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30. Correlation of higher levels of soluble TNF-R1 with a shorter survival, independent of age, in recurrent glioblastoma

Author

Ahluwalia, Manmeet S., Bou-Anak, Stephanie, Burgett, Monica E., Sarmey, Nehaw, Khosla, Divya, Dahiya, Saurabh, Weil, Robert J., Bae, Eunnyung, Huang, Ping, McGraw, Mary, Grove, Lisa M., Olman, Mitchell A., Prayson, Richard A., Suh, John H., Gillespie, G. Yancey, Barnholtz-Sloan, Jill, Nowacki, Amy S., Barnett, Gene H., and Gladson, Candece L.

Published
2017
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33. Urokinase receptor mediates lung fibroblast attachment and migration toward provisional matrix proteins through interaction with multiple integrins

Author

Zhu, Sha, Gladson, Candece L., White, Kimberly E., Ding, Qiang, Stewart, Jerry, Jr., Jin, Tong H., Chapman, Harold A., Jr., and Olman, Mitchell A.

Subjects
Fibronectins -- Properties, Urokinase -- Properties, Fibroblasts -- Properties, Lungs -- Properties, Lung diseases -- Diagnosis, Biological sciences
Abstract

Fibroblasts from patients with pulmonary fibrosis express higher levels of the receptor for urokinase, and the extent of fibrosis in some animal models exhibits a dependence on the urokinase receptor. Recent observations have identified the urokinase receptor as a trans-interacting receptor with consequences on signaling and cell responses that vary depending on its interacting partner, the relative levels of expression, and the state of cellular transformation. We undertook this study to define the urokinase-type plasminogen activator cellular receptor (u-PAR)-integrin interactions and to determine the functional consequences of such interactions on normal human lung fibroblast attachment and migration. u-PAR colocalizes in lammelipodia/filopodia with relevant integrins that mediate fibroblast attachment and spreading on the provisional matrix proteins vitronectin, fibronectin, and collagens. Inhibitory antibody studies have revealed that human lung fibroblasts utilize [[alpha].sub.v][[beta].sub.5] to attach to vitronectin, predominantly [[alpha].sub.5][[beta].sub.1] (and [[alpha].sub.v][[beta].sub.3]) to attach to fibronectin, and [[alpha].sub.1][[beta].sub.1], [[alpha].sub.2][[beta].sub.1], and [[alpha].sub.3][[beta].sub.1] to attach to collagen. Blocking studies with [alpha]-integrin subunit decoy peptides and u-PAR neutralizing antibodies indicate that u-PAR modulates the integrin-mediated attachment to purified provisional matrix proteins, to anti-integrin antibodies, or to fibroproliferative lesions from fibrotic lungs. Furthermore, these decoy peptides blunt fibroblast spreading and migration. We show that u-PAR can interact with multiple [alpha]-integrins but with a preference for [[alpha].sub.3]. Taken together, these data demonstrate that u-PAR may interact with multiple integrins in normal human lung fibroblasts thereby promoting attachment, spreading, and migration. Modulation of fibroblast invasion would be expected to lead to amelioration of fibroproliferative diseases of the lung. pulmonary; fibrosis; plasmin

Published
2009

37. Laminin alpha 2 enables glioblastoma stem cell growth

Author

Lathia, Justin D., Li, Meizhang, Hall, Peter E., Gallagher, Joseph, Hale, James S., Wu, Qiulian, Venere, Monica, Levy, Emily, Rani, Sandhya M.R., Huang, Ping, Bae, Eunnyung, Selfridge, Julia, Cheng, Lin, Guvenc, Hacer, McLendon, Roger E., Nakano, Ichiro, Sloan, Andrew E., Phillips, Heidi S., Lai, Albert, Gladson, Candece L., Bredel, Markus, Bao, Shideng, Hjelmeland, Anita B., and Rich, Jeremy N.

Published
2012
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48. Macropinocytosis of Bevacizumab by Glioblastoma Cells in the Perivascular Niche Affects their Survival

Author

Müller-Greven, Gaëlle, primary, Carlin, Cathleen R., additional, Burgett, Monica E., additional, Ahluwalia, Manmeet S., additional, Lauko, Adam, additional, Nowacki, Amy S., additional, Herting, Cameron J., additional, Qadan, Maha A., additional, Bredel, Markus, additional, Toms, Steven A., additional, Lathia, Justin D., additional, Hambardzumyan, Dolores, additional, Sarkaria, Jann N., additional, Hamerlik, Petra, additional, and Gladson, Candece L., additional

Published
2017
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50. Correlation of higher levels of soluble TNF-R1 with a shorter survival, independent of age, in recurrent glioblastoma

Author

Ahluwalia, Manmeet S., primary, Bou-Anak, Stephanie, additional, Burgett, Monica E., additional, Sarmey, Nehaw, additional, Khosla, Divya, additional, Dahiya, Saurabh, additional, Weil, Robert J., additional, Bae, Eunnyung, additional, Huang, Ping, additional, McGraw, Mary, additional, Grove, Lisa M., additional, Olman, Mitchell A., additional, Prayson, Richard A., additional, Suh, John H., additional, Gillespie, G. Yancey, additional, Barnholtz-Sloan, Jill, additional, Nowacki, Amy S., additional, Barnett, Gene H., additional, and Gladson, Candece L., additional

Published
2016
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