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1. Brain charts for the human lifespan

Author

Bethlehem, R. A. I., Seidlitz, J., White, S. R., Vogel, J. W., Anderson, K. M., Adamson, C., Adler, S., Alexopoulos, G. S., Anagnostou, E., Areces-Gonzalez, A., Astle, D. E., Auyeung, B., Ayub, M., Bae, J., Ball, G., Baron-Cohen, S., Beare, R., Bedford, S. A., Benegal, V., Beyer, F., Blangero, J., Blesa Cábez, M., Boardman, J. P., Borzage, M., Bosch-Bayard, J. F., Bourke, N., Calhoun, V. D., Chakravarty, M. M., Chen, C., Chertavian, C., Chetelat, G., Chong, Y. S., Cole, J. H., Corvin, A., Costantino, M., Courchesne, E., Crivello, F., Cropley, V. L., Crosbie, J., Crossley, N., Delarue, M., Delorme, R., Desrivieres, S., Devenyi, G. A., Di Biase, M. A., Dolan, R., Donald, K. A., Donohoe, G., Dunlop, K., Edwards, A. D., Elison, J. T., Ellis, C. T., Elman, J. A., Eyler, L., Fair, D. A., Feczko, E., Fletcher, P. C., Fonagy, P., Franz, C. E., Galan-Garcia, L., Gholipour, A., Giedd, J., Gilmore, J. H., Glahn, D. C., Goodyer, I. M., Grant, P. E., Groenewold, N. A., Gunning, F. M., Gur, R. E., Gur, R. C., Hammill, C. F., Hansson, O., Hedden, T., Heinz, A., Henson, R. N., Heuer, K., Hoare, J., Holla, B., Holmes, A. J., Holt, R., Huang, H., Im, K., Ipser, J., Jack, Jr, C. R., Jackowski, A. P., Jia, T., Johnson, K. A., Jones, P. B., Jones, D. T., Kahn, R. S., Karlsson, H., Karlsson, L., Kawashima, R., Kelley, E. A., Kern, S., Kim, K. W., Kitzbichler, M. G., Kremen, W. S., Lalonde, F., Landeau, B., Lee, S., Lerch, J., Lewis, J. D., Li, J., Liao, W., Liston, C., Lombardo, M. V., Lv, J., Lynch, C., Mallard, T. T., Marcelis, M., Markello, R. D., Mathias, S. R., Mazoyer, B., McGuire, P., Meaney, M. J., Mechelli, A., Medic, N., Misic, B., Morgan, S. E., Mothersill, D., Nigg, J., Ong, M. Q. W., Ortinau, C., Ossenkoppele, R., Ouyang, M., Palaniyappan, L., Paly, L., Pan, P. M., Pantelis, C., Park, M. M., Paus, T., Pausova, Z., Paz-Linares, D., Pichet Binette, A., Pierce, K., Qian, X., Qiu, J., Qiu, A., Raznahan, A., Rittman, T., Rodrigue, A., Rollins, C. K., Romero-Garcia, R., Ronan, L., Rosenberg, M. D., Rowitch, D. H., Salum, G. A., Satterthwaite, T. D., Schaare, H. L., Schachar, R. J., Schultz, A. P., Schumann, G., Schöll, M., Sharp, D., Shinohara, R. T., Skoog, I., Smyser, C. D., Sperling, R. A., Stein, D. J., Stolicyn, A., Suckling, J., Sullivan, G., Taki, Y., Thyreau, B., Toro, R., Traut, N., Tsvetanov, K. A., Turk-Browne, N. B., Tuulari, J. J., Tzourio, C., Vachon-Presseau, É., Valdes-Sosa, M. J., Valdes-Sosa, P. A., Valk, S. L., van Amelsvoort, T., Vandekar, S. N., Vasung, L., Victoria, L. W., Villeneuve, S., Villringer, A., Vértes, P. E., Wagstyl, K., Wang, Y. S., Warfield, S. K., Warrier, V., Westman, E., Westwater, M. L., Whalley, H. C., Witte, A. V., Yang, N., Yeo, B., Yun, H., Zalesky, A., Zar, H. J., Zettergren, A., Zhou, J. H., Ziauddeen, H., Zugman, A., Zuo, X. N., Bullmore, E. T., and Alexander-Bloch, A. F.

Published
2022
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2. Large-scale analysis of structural brain asymmetries during neurodevelopment : Associations with age and sex in 4265 children and adolescents

Author

Kurth, F, Schijven, D, van den Heuvel, O A, Hoogman, M, van Rooij, D, Stein, D J, Buitelaar, J K, Bölte, S, Auzias, G, Kushki, A, Venkatasubramanian, G, Rubia, K, Bollmann, S, Isaksson, Johan, Jaspers-Fayer, F, Marsh, R, Batistuzzo, M C, Arnold, P D, Bressan, R A, Stewart, S E, Gruner, P, Sorensen, L, Pan, P M, Silk, T J, Gur, R C, Cubillo, A I, Haavik, J, O'Gorman Tuura, R L, Hartman, C A, Calvo, R, McGrath, J, Calderoni, S, Jackowski, A, Chantiluke, K C, Satterthwaite, T D, Busatto, G F, Nigg, J T, Gur, R E, Retico, A, Tosetti, M, Gallagher, L, Szeszko, P R, Neufeld, Janina, Ortiz, A E, Ghisleni, C, Lazaro, L, Hoekstra, P J, Anagnostou, E, Hoekstra, L, Simpson, B, Plessen, J K, Deruelle, C, Soreni, N, James, A, Narayanaswamy, J, Reddy, J Y, Fitzgerald, J, Bellgrove, M A, Salum, G A, Janssen, J, Muratori, F, Vila, M, Giral, M Garcia, Ameis, S H, Bosco, P, Remnélius, K Lundin, Huyser, C, Pariente, J C, Jalbrzikowski, M, Rosa, P G, O'Hearn, K M, Ehrlich, S, Mollon, J, Zugman, A, Christakou, A, Arango, C, Fisher, S E, Kong, X, Franke, B, Medland, S E, Thomopoulos, S I, Jahanshad, N, Glahn, D C, Thompson, P M, Francks, C, Lueders, Eileen, Kurth, F, Schijven, D, van den Heuvel, O A, Hoogman, M, van Rooij, D, Stein, D J, Buitelaar, J K, Bölte, S, Auzias, G, Kushki, A, Venkatasubramanian, G, Rubia, K, Bollmann, S, Isaksson, Johan, Jaspers-Fayer, F, Marsh, R, Batistuzzo, M C, Arnold, P D, Bressan, R A, Stewart, S E, Gruner, P, Sorensen, L, Pan, P M, Silk, T J, Gur, R C, Cubillo, A I, Haavik, J, O'Gorman Tuura, R L, Hartman, C A, Calvo, R, McGrath, J, Calderoni, S, Jackowski, A, Chantiluke, K C, Satterthwaite, T D, Busatto, G F, Nigg, J T, Gur, R E, Retico, A, Tosetti, M, Gallagher, L, Szeszko, P R, Neufeld, Janina, Ortiz, A E, Ghisleni, C, Lazaro, L, Hoekstra, P J, Anagnostou, E, Hoekstra, L, Simpson, B, Plessen, J K, Deruelle, C, Soreni, N, James, A, Narayanaswamy, J, Reddy, J Y, Fitzgerald, J, Bellgrove, M A, Salum, G A, Janssen, J, Muratori, F, Vila, M, Giral, M Garcia, Ameis, S H, Bosco, P, Remnélius, K Lundin, Huyser, C, Pariente, J C, Jalbrzikowski, M, Rosa, P G, O'Hearn, K M, Ehrlich, S, Mollon, J, Zugman, A, Christakou, A, Arango, C, Fisher, S E, Kong, X, Franke, B, Medland, S E, Thomopoulos, S I, Jahanshad, N, Glahn, D C, Thompson, P M, Francks, C, and Lueders, Eileen

Abstract

Only a small number of studies have assessed structural differences between the two hemispheres during childhood and adolescence. However, the existing findings lack consistency or are restricted to a particular brain region, a specific brain feature, or a relatively narrow age range. Here, we investigated associations between brain asymmetry and age as well as sex in one of the largest pediatric samples to date (n = 4265), aged 1-18 years, scanned at 69 sites participating in the ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) consortium. Our study revealed that significant brain asymmetries already exist in childhood, but their magnitude and direction depend on the brain region examined and the morphometric measurement used (cortical volume or thickness, regional surface area, or subcortical volume). With respect to effects of age, some asymmetries became weaker over time while others became stronger; sometimes they even reversed direction. With respect to sex differences, the total number of regions exhibiting significant asymmetries was larger in females than in males, while the total number of measurements indicating significant asymmetries was larger in males (as we obtained more than one measurement per cortical region). The magnitude of the significant asymmetries was also greater in males. However, effect sizes for both age effects and sex differences were small. Taken together, these findings suggest that cerebral asymmetries are an inherent organizational pattern of the brain that manifests early in life. Overall, brain asymmetry appears to be relatively stable throughout childhood and adolescence, with some differential effects in males and females.

Published
2024
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3. Publisher Correction: Brain charts for the human lifespan

Author

Bethlehem, R. A. I., Seidlitz, J., White, S. R., Vogel, J. W., Anderson, K. M., Adamson, C., Adler, S., Alexopoulos, G. S., Anagnostou, E., Areces-Gonzalez, A., Astle, D. E., Auyeung, B., Ayub, M., Bae, J., Ball, G., Baron-Cohen, S., Beare, R., Bedford, S. A., Benegal, V., Beyer, F., Blangero, J., Blesa Cábez, M., Boardman, J. P., Borzage, M., Bosch-Bayard, J. F., Bourke, N., Calhoun, V. D., Chakravarty, M. M., Chen, C., Chertavian, C., Chetelat, G., Chong, Y. S., Cole, J. H., Corvin, A., Costantino, M., Courchesne, E., Crivello, F., Cropley, V. L., Crosbie, J., Crossley, N., Delarue, M., Delorme, R., Desrivieres, S., Devenyi, G. A., Di Biase, M. A., Dolan, R., Donald, K. A., Donohoe, G., Dunlop, K., Edwards, A. D., Elison, J. T., Ellis, C. T., Elman, J. A., Eyler, L., Fair, D. A., Feczko, E., Fletcher, P. C., Fonagy, P., Franz, C. E., Galan-Garcia, L., Gholipour, A., Giedd, J., Gilmore, J. H., Glahn, D. C., Goodyer, I. M., Grant, P. E., Groenewold, N. A., Gunning, F. M., Gur, R. E., Gur, R. C., Hammill, C. F., Hansson, O., Hedden, T., Heinz, A., Henson, R. N., Heuer, K., Hoare, J., Holla, B., Holmes, A. J., Holt, R., Huang, H., Im, K., Ipser, J., Jack, Jr, C. R., Jackowski, A. P., Jia, T., Johnson, K. A., Jones, P. B., Jones, D. T., Kahn, R. S., Karlsson, H., Karlsson, L., Kawashima, R., Kelley, E. A., Kern, S., Kim, K. W., Kitzbichler, M. G., Kremen, W. S., Lalonde, F., Landeau, B., Lee, S., Lerch, J., Lewis, J. D., Li, J., Liao, W., Liston, C., Lombardo, M. V., Lv, J., Lynch, C., Mallard, T. T., Marcelis, M., Markello, R. D., Mathias, S. R., Mazoyer, B., McGuire, P., Meaney, M. J., Mechelli, A., Medic, N., Misic, B., Morgan, S. E., Mothersill, D., Nigg, J., Ong, M. Q. W., Ortinau, C., Ossenkoppele, R., Ouyang, M., Palaniyappan, L., Paly, L., Pan, P. M., Pantelis, C., Park, M. M., Paus, T., Pausova, Z., Paz-Linares, D., Pichet Binette, A., Pierce, K., Qian, X., Qiu, J., Qiu, A., Raznahan, A., Rittman, T., Rodrigue, A., Rollins, C. K., Romero-Garcia, R., Ronan, L., Rosenberg, M. D., Rowitch, D. H., Salum, G. A., Satterthwaite, T. D., Schaare, H. L., Schachar, R. J., Schultz, A. P., Schumann, G., Schöll, M., Sharp, D., Shinohara, R. T., Skoog, I., Smyser, C. D., Sperling, R. A., Stein, D. J., Stolicyn, A., Suckling, J., Sullivan, G., Taki, Y., Thyreau, B., Toro, R., Traut, N., Tsvetanov, K. A., Turk-Browne, N. B., Tuulari, J. J., Tzourio, C., Vachon-Presseau, É., Valdes-Sosa, M. J., Valdes-Sosa, P. A., Valk, S. L., van Amelsvoort, T., Vandekar, S. N., Vasung, L., Victoria, L. W., Villeneuve, S., Villringer, A., Vértes, P. E., Wagstyl, K., Wang, Y. S., Warfield, S. K., Warrier, V., Westman, E., Westwater, M. L., Whalley, H. C., Witte, A. V., Yang, N., Yeo, B., Yun, H., Zalesky, A., Zar, H. J., Zettergren, A., Zhou, J. H., Ziauddeen, H., Zugman, A., Zuo, X. N., Bullmore, E. T., and Alexander-Bloch, A. F.

Published
2022
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4. Genome-wide autozygosity is associated with lower general cognitive ability

Author

Howrigan, D P, Simonson, M A, Davies, G, Harris, S E, Tenesa, A, Starr, J M, Liewald, D C, Deary, I J, McRae, A, Wright, M J, Montgomery, G W, Hansell, N, Martin, N G, Payton, A, Horan, M, Ollier, W E, Abdellaoui, A, Boomsma, D I, DeRosse, P, Knowles, E E M, Glahn, D C, Djurovic, S, Melle, I, Andreassen, O A, Christoforou, A, Steen, V M, Hellard, S L, Sundet, K, Reinvang, I, Espeseth, T, Lundervold, A J, Giegling, I, Konte, B, Hartmann, A M, Rujescu, D, Roussos, P, Giakoumaki, S, Burdick, K E, Bitsios, P, Donohoe, G, Corley, R P, Visscher, P M, Pendleton, N, Malhotra, A K, Neale, B M, Lencz, T, and Keller, M C

Published
2016
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5. Cognitive functioning throughout adulthood and illness stages in individuals with psychotic disorders and their unaffected siblings

Author

Velthorst E., Mollon J., Murray R. M., de Haan L., Germeys I. M., Glahn D. C., Arango C., van der Ven E., Di Forti M., Bernardo M., Guloksuz S., Delespaul P., Mezquida G., Amoretti S., Bobes J., Saiz P. A., Garcia-Portilla M. P., Santos J. L., Jimenez-Lopez E., Sanjuan J., Aguilar E. J., Arrojo M., Carracedo A., Lopez G., Gonzalez-Penas J., Parellada M., Atbasoglu C., Saka M. C., Ucok A., Alptekin K., Akdede B., Binbay T., Altinyazar V., Ulas H., Yalincetin B., Gumus-Akay G., Beyaz B. C., Soygur H., Cankurtaran E. S., Kaymak S. U., Maric N. P., Mihaljevic M. M., Petrovic S. A., Mirjanic T., Del-Ben C. M., Ferraro L., Gayer-Anderson C., Jones P. B., Jongsma H. E., Kirkbride J. B., La Cascia C., Lasalvia A., Tosato S., Llorca P. -M., Menezes P. R., Morgan C., Quattrone D., Menchetti M., Selten J. -P., Szoke A., Tarricone I., Tortelli A., McGuire P., Valmaggia L., Kempton M. J., van der Gaag M., Riecher-Rossler A., Bressan R. A., Barrantes-Vidal N., Nelson B., McGorry P., Pantelis C., Krebs M. -O., Ruhrmann S., Sachs G., Rutten B. P. F., van Os J., Alizadeh B. Z., van Amelsvoort T., Bartels-Velthuis A. A., Bruggeman R., van Beveren N. J., Luykx J. J., Cahn W., Simons C. J. P., Kahn R. S., Schirmbeck F., van Winkel R., Calem M., Tognin S., Modinos G., Pisani S., Kraan T. C., van Dam D. S., Burger N., Amminger G. P., Politis A., Goodall J., Borgwardt S., Studerus E., Gadelha A., Brietzke E., Asevedo G., Asevedo E., Zugman A., Dominguez-Martinez T., Monsonet M., Cristobal-Narvaez P., Racioppi A., Kwapil T. R., Kazes M., Daban C., Bourgin J., Gay O., Mam-Lam-Fook C., Nordholm D., Rander L., Krakauer K., Glenthoj L. B., Glenthoj B., Gebhard D., Arnhold J., Klosterkotter J., Lasser I., Winklbaur B., Reichenberg A., Velthorst E., Mollon J., Murray R.M., de Haan L., Germeys I.M., Glahn D.C., Arango C., van der Ven E., Di Forti M., Bernardo M., Guloksuz S., Delespaul P., Mezquida G., Amoretti S., Bobes J., Saiz P.A., Garcia-Portilla M.P., Santos J.L., Jimenez-Lopez E., Sanjuan J., Aguilar E.J., Arrojo M., Carracedo A., Lopez G., Gonzalez-Penas J., Parellada M., Atbasoglu C., Saka M.C., Ucok A., Alptekin K., Akdede B., Binbay T., Altinyazar V., Ulas H., Yalincetin B., Gumus-Akay G., Beyaz B.C., Soygur H., Cankurtaran E.S., Kaymak S.U., Maric N.P., Mihaljevic M.M., Petrovic S.A., Mirjanic T., Del-Ben C.M., Ferraro L., Gayer-Anderson C., Jones P.B., Jongsma H.E., Kirkbride J.B., La Cascia C., Lasalvia A., Tosato S., Llorca P.-M., Menezes P.R., Morgan C., Quattrone D., Menchetti M., Selten J.-P., Szoke A., Tarricone I., Tortelli A., McGuire P., Valmaggia L., Kempton M.J., van der Gaag M., Riecher-Rossler A., Bressan R.A., Barrantes-Vidal N., Nelson B., McGorry P., Pantelis C., Krebs M.-O., Ruhrmann S., Sachs G., Rutten B.P.F., van Os J., Alizadeh B.Z., van Amelsvoort T., Bartels-Velthuis A.A., Bruggeman R., van Beveren N.J., Luykx J.J., Cahn W., Simons C.J.P., Kahn R.S., Schirmbeck F., van Winkel R., Calem M., Tognin S., Modinos G., Pisani S., Kraan T.C., van Dam D.S., Burger N., Amminger G.P., Politis A., Goodall J., Borgwardt S., Studerus E., Gadelha A., Brietzke E., Asevedo G., Asevedo E., Zugman A., Dominguez-Martinez T., Monsonet M., Cristobal-Narvaez P., Racioppi A., Kwapil T.R., Kazes M., Daban C., Bourgin J., Gay O., Mam-Lam-Fook C., Nordholm D., Rander L., Krakauer K., Glenthoj L.B., Glenthoj B., Gebhard D., Arnhold J., Klosterkotter J., Lasser I., Winklbaur B., Reichenberg A., RS: MHeNs - R2 - Mental Health, Psychiatrie & Neuropsychologie, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, Neurosciences, Psychiatry, Clinical Developmental Psychology, World Health Organization (WHO) Collaborating Center, Life Course Epidemiology (LCE), Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Clinical Cognitive Neuropsychiatry Research Program (CCNP), Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET), Adult Psychiatry, APH - Mental Health, Amsterdam Neuroscience - Complex Trait Genetics, and Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep

Subjects
0301 basic medicine, validity, medicine.medical_treatment, CHILDHOOD, Neuropsychological Tests, FAMÍLIA, episode, Cognition, 0302 clinical medicine, DEFICITS, Settore MED/48 -Scienze Infermierist. e Tecn. Neuro-Psichiatriche e Riabilitat, Medicine, Cognitive impairment, Psychiatry, Symptom severity, Cannabis use, IMPAIRMENT, ABILITY, Psychiatry and Mental health, Schizophrenia, RELIABILITY, Neuropsychological Test, Life Sciences & Biomedicine, Human, Clinical psychology, Adult, Biochemistry & Molecular Biology, impairment, schizophrenia-patients, ability, GENETIC RISK, Psychotic Disorder, SCHIZOPHRENIA-PATIENTS, 03 medical and health sciences, Cellular and Molecular Neuroscience, SDG 3 - Good Health and Well-being, Settore M-PSI/08 - Psicologia Clinica, Humans, In patient, Cognitive skill, VALIDITY, Antipsychotic, Molecular Biology, Settore MED/25 - Psichiatria, Aged, Cross-Sectional Studie, DECLINE, Science & Technology, reliability, business.industry, Working memory, Siblings, Neurosciences, Diagnostic markers, medicine.disease, Cross-Sectional Studies, 030104 developmental biology, deficits, Psychotic Disorders, PSYCHOSIS, COGNITION, MULTICENTRIC STUDY, Neurosciences & Neurology, business, EPISODE, 030217 neurology & neurosurgery
Abstract

The European Community’s Seventh Framework Programme under grant agreement No. HEALTH-F2-2010-241909 (EUGEI); The Spanish sample was supported by the Spanish Ministry of Science and Innovation, Instituto de Salud Carlos III (SAM16PE07CP1, PI16/02012, PI19/024) (...), Velthorst, E., Mollon, J., Murray, R.M., de Haan, L., Germeys, I.M., Glahn, D.C., Arango, C., van der Ven, E., Di Forti, M., Bernardo, M., Guloksuz, S., Delespaul, P., Mezquida, G., Amoretti, S., Bobes, J., Saiz, P.A., García-Portilla, M.P., Santos, J.L., Jiménez-López, E., Sanjuan, J., Aguilar, E.J., Arrojo, M., Carracedo, A., López, G., González-Peñas, J., Parellada, M., Atbaşoğlu, C., Saka, M.C., Üçok, A., Alptekin, K., Akdede, B., Binbay, T., Altınyazar, V., Ulaş, H., Yalınçetin, B., Gümüş-Akay, G., Beyaz, B.C., Soygür, H., Cankurtaran, E.Ş., Kaymak, S.U., Maric, N.P., Mihaljevic, M.M., Petrovic, S.A., Mirjanic, T., Del-Ben, C.M., Ferraro, L., Gayer-Anderson, C., Jones, P.B., Jongsma, H.E., Kirkbride, J.B., La Cascia, C., Lasalvia, A., Tosato, S., Llorca, P.-M., Menezes, P.R., Morgan, C., Quattrone, D., Menchetti, M., Selten, J.-P., Szöke, A., Tarricone, I., Tortelli, A., McGuire, P., Valmaggia, L., Kempton, M.J., van der Gaag, M., Riecher-Rössler, A., Bressan, R.A., Barrantes-Vidal, N., Nelson, B., McGorry, P., Pantelis, C., Krebs, M.-O., Ruhrmann, S., Sachs, G., Rutten, B.P.F., van Os, J., Alizadeh, B.Z., van Amelsvoort, T., Bartels-Velthuis, A.A., Bruggeman, R., van Beveren, N.J., Luykx, J.J., Cahn, W., Simons, C.J.P., Kahn, R.S., Schirmbeck, F., van Winkel, R., Calem, M., Tognin, S., Modinos, G., Pisani, S., Kraan, T.C., van Dam, D.S., Burger, N., Amminger, G.P., Politis, A., Goodall, J., Borgwardt, S., Studerus, E., Gadelha, A., Brietzke, E., Asevedo, G., Asevedo, E., Zugman, A., Domínguez-Martínez, T., Monsonet, M., Cristóbal-Narváez, P., Racioppi, A., Kwapil, T.R., Kazes, M., Daban, C., Bourgin, J., Gay, O., Mam-Lam-Fook, C., Nordholm, D., Rander, L., Krakauer, K., Glenthøj, L.B., Glenthøj, B., Gebhard, D., Arnhold, J., Klosterkötter, J., Lasser, I., Winklbaur, B., Reichenberg, A., EU-GEI High Risk Study

Published
2021
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6. Infant Motor Development Is Associated with Adult Cognitive Categorisation in a Longitudinal Birth Cohort Study

Author

Murray, G. K., Veijola, J., Moilanen, K., Miettunen, J., Glahn, D. C., Cannon, T. D., Jones, P. B., and Isohanni, M.

Abstract

Background: The relationship between the age of reaching infant developmental milestones and later intellectual function within the normal population remains unresolved. We hypothesised that the age of learning to stand in infancy would be associated with adult executive function and that the association would be apparent throughout the range of abilities, rather than confined to extremes. Methods: The Northern Finland 1966 Birth Cohort is based upon 12,058 live-born children in a geographic and temporally defined population. Information on age at learning to stand without support was obtained at one year. At age 33-35 a random sample of 104 subjects underwent a neuropsychological test battery including tests of executive function (cognitive categorisation), visuo-spatial memory, verbal learning and visual object learning. We investigated associations between developmental data and adult neuropsychological test scores. Results: There was a significant linear relationship between age of learning to stand and adult categorisation: the earlier the attainment of the milestone, the better was the categorisation. No such relationships were observed between infant neurodevelopment and adult cognition in other neuropsychological domains. Conclusion: Even within the normal range of development, early development in the gross motor domain is associated with better adult executive function (in tests of categorisation). Investigation of the determinants and sequelae of normal neural development will facilitate research into a variety of neurodevelopmental disorders.

Published
2006
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7. GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium

Author

Trampush, J W, Yang, M LZ, Yu, J, Knowles, E, Davies, G, Liewald, D C, Starr, J M, Djurovic, S, Melle, I, Sundet, K, Christoforou, A, Reinvang, I, DeRosse, P, Lundervold, A J, Steen, V M, Espeseth, T, Räikkönen, K, Widen, E, Palotie, A, Eriksson, J G, Giegling, I, Konte, B, Roussos, P, Giakoumaki, S, Burdick, K E, Payton, A, Ollier, W, Horan, M, Chiba-Falek, O, Attix, D K, Need, A C, Cirulli, E T, Voineskos, A N, Stefanis, N C, Avramopoulos, D, Hatzimanolis, A, Arking, D E, Smyrnis, N, Bilder, R M, Freimer, N A, Cannon, T D, London, E, Poldrack, R A, Sabb, F W, Congdon, E, Conley, E D, Scult, M A, Dickinson, D, Straub, R E, Donohoe, G, Morris, D, Corvin, A, Gill, M, Hariri, A R, Weinberger, D R, Pendleton, N, Bitsios, P, Rujescu, D, Lahti, J, Le Hellard, S, Keller, M C, Andreassen, O A, Deary, I J, Glahn, D C, Malhotra, A K, and Lencz, T

Published
2017
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8. Genetic Control over the Resting Brain

Author

Glahn, D. C., Winkler, A. M., Kochunov, P., Almasy, L., Duggirala, R., Carless, M. A., Curran, J. C., Olvera, R. L., Laird, A. R., Smith, S. M., Beckmann, C. F., Fox, P. T., Blangero, J., and Raichle, Marcus E.

Published
2010
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10. Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium

Author

van Erp, T GM, Hibar, D P, Rasmussen, J M, Glahn, D C, Pearlson, G D, Andreassen, O A, Agartz, I, Westlye, L T, Haukvik, U K, Dale, A M, Melle, I, Hartberg, C B, Gruber, O, Kraemer, B, Zilles, D, Donohoe, G, Kelly, S, McDonald, C, Morris, D W, Cannon, D M, Corvin, A, Machielsen, M WJ, Koenders, L, de Haan, L, Veltman, D J, Satterthwaite, T D, Wolf, D H, Gur, R C, Gur, R E, Potkin, S G, Mathalon, D H, Mueller, B A, Preda, A, Macciardi, F, Ehrlich, S, Walton, E, Hass, J, Calhoun, V D, Bockholt, H J, Sponheim, S R, Shoemaker, J M, van Haren, N EM, Pol, H EH, Ophoff, R A, Kahn, R S, Roiz-Santiañez, R, Crespo-Facorro, B, Wang, L, Alpert, K I, Jönsson, E G, Dimitrova, R, Bois, C, Whalley, H C, McIntosh, A M, Lawrie, S M, Hashimoto, R, Thompson, P M, and Turner, J A

Published
2016
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11. Erratum: GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium

Author

Trampush, J W, Yang, M L Z, Yu, J, Knowles, E, Davies, G, Liewald, D C, Starr, J M, Djurovic, S, Melle, I, Sundet, K, Christoforou, A, Reinvang, I, DeRosse, P, Lundervold, A J, Steen, V M, Espeseth, T, Räikkönen, K, Widen, E, Palotie, A, Eriksson, J G, Giegling, I, Konte, B, Roussos, P, Giakoumaki, S, Burdick, K E, Payton, A, Ollier, W, Horan, M, Chiba-Falek, O, Attix, D K, Need, A C, Cirulli, E T, Voineskos, A N, Stefanis, N C, Avramopoulos, D, Hatzimanolis, A, Arking, D E, Smyrnis, N, Bilder, R M, Freimer, N A, Cannon, T D, London, E, Poldrack, R A, Sabb, F W, Congdon, E, Conley, E D, Scult, M A, Dickinson, D, Straub, R E, Donohoe, G, Morris, D, Corvin, A, Gill, M, Hariri, A R, Weinberger, D R, Pendleton, N, Bitsios, P, Rujescu, D, Lahti, J, Le Hellard, S, Keller, M C, Andreassen, O A, Deary, I J, Glahn, D C, Malhotra, A K, and Lencz, T

Published
2017
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12. Molecular genetic evidence for overlap between general cognitive ability and risk for schizophrenia: a report from the Cognitive Genomics consorTium (COGENT)

Author

Lencz, T, Knowles, E, Davies, G, Guha, S, Liewald, D C, Starr, J M, Djurovic, S, Melle, I, Sundet, K, Christoforou, A, Reinvang, I, Mukherjee, S, DeRosse, Pamela, Lundervold, A, Steen, V M, John, M, Espeseth, T, Räikkönen, K, Widen, E, Palotie, A, Eriksson, J G, Giegling, I, Konte, B, Ikeda, M, Roussos, P, Giakoumaki, S, Burdick, K E, Payton, A, Ollier, W, Horan, M, Donohoe, G, Morris, D, Corvin, A, Gill, M, Pendleton, N, Iwata, N, Darvasi, A, Bitsios, P, Rujescu, D, Lahti, J, Hellard, S L, Keller, M C, Andreassen, O A, Deary, I J, Glahn, D C, and Malhotra, A K

Published
2014
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29. Author Correction: Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

Author

Davies, G., Lam, M., Harris, S. E., TRAMPUSH, J. W., LUCIANO, M., HILL, W. D., HAGENAARS, S. P., RITCHIE, S. J., MARIONI, R. E., FAWNS-RITCHIE, C., LIEWALD, D. C. M., OKELY, J. A., AHOLA-OLLI, A. V., BARNES, C. L. K., Bertram, L., BIS, J. C., BURDICK, K. E., CHRISTOFOROU, A., DEROSSE, P., Djurovic, S., ESPESETH, T., GIAKOUMAKI, S., GIDDALURU, S., GUSTAVSON, D. E., Hayward, C., Hofer, E., KARLSSON, R., KNOWLES, E., Lahti, J., Leber, M., MATHER, K. A., Melle, I., Morris, D., OLDMEADOW, C., PALVIAINEN, T., PAYTON, A., PAZOKI, R., PETROVIC, K., Reynolds, C. A., SARGURUPREMRAJ, M., Scholz, M., Smith, J. A., SMITH, A. V., TERZIKHAN, N., THALAMUTHU, A., TROMPET, S., VAN DER LEE, S. J., WARE, E. B., WINDHAM, B. G., WRIGHT, M. J., Yang, J., Yu, J., Ames, D., Amin, N., Amouyel, P., ANDREASSEN, O. A., ARMSTRONG, N. J., ASSAREH, A. A., ATTIA, J. R., ATTIX, D., AVRAMOPOULOS, D., BENNETT, D. A., BOHMER, A. C., BOYLE, P. A., BRODATY, H., Campbell, H., CANNON, T. D., CIRULLI, E. T., CONGDON, E., CONLEY, E. D., CORLEY, J., COX, S. R., DALE, A. M., DEHGHAN, A., Dick, D., Dickinson, D., ERIKSSON, J. G., EVANGELOU, E., FAUL, J. D., Ford, I., FREIMER, N. A., Gao, H., Giegling, I., GILLESPIE, N. A., GORDON, S. D., GOTTESMAN, R. F., GRISWOLD, M. E., GUDNASON, V., HARRIS, T. B., HARTMANN, A. M., Hatzimanolis, A., Heiss, G., HOLLIDAY, E. G., Joshi, P. K., KAHONEN, M., KARDIA, S. L. R., KARLSSON, I., KLEINEIDAM, L., KNOPMAN, D. S., KOCHAN, N. A., Konte, B., KWOK, J. B., LE HELLARD, S., Lee, T., LEHTIMAKI, T., Li, S. C., Lill, C. M., Liu, T., KOINI, M., London, E., LONGSTRETH, W. T., Jr., LOPEZ, O. L., LOUKOLA, A., LUCK, T., LUNDERVOLD, A. J., LUNDQUIST, A., LYYTIKAINEN, L. P., Martin, N. G., MONTGOMERY, G. W., MURRAY, A. D., NEED, A. C., NOORDAM, R., Nyberg, L., OLLIER, W., PAPENBERG, G., PATTIE, A., POLASEK, O., POLDRACK, R. A., PSATY, B. M., REPPERMUND, S., RIEDEL-HELLER, S. G., ROSE, R. J., ROTTER, J. I., ROUSSOS, P., ROVIO, S. P., SABA, Y., SABB, F. W., SACHDEV, P. S., SATIZABAL, C. L., Schmid, M., Scott, R. J., SCULT, M. A., SIMINO, J., SLAGBOOM, P. E., SMYRNIS, N., Soumare, A., Stefanis, N. C., STOTT, D. J., STRAUB, R. E., SUNDET, K., Taylor, A. M., TAYLOR, K. D., TZOULAKI, I., Tzourio, C., Uitterlinden, A., Vitart, V., VOINESKOS, A. N., Kaprio, J., Wagner, M., Wagner, H., WEINHOLD, L., WEN, K. H., WIDEN, E., Yang, Q., Zhao, W., ADAMS, H. H. H., ARKING, D. E., Bilder, R. M., BITSIOS, P., BOERWINKLE, E., CHIBA-FALEK, O., Corvin, A., DE JAGER, P. L., Debette, S., Donohoe, G., Elliott, P., FITZPATRICK, A. L., Gill, M., GLAHN, D. C., HAGG, S., HANSELL, N. K., HARIRI, A. R., Ikram, M. A., JUKEMA, J. W., VUOKSIMAA, E., KELLER, M. C., KREMEN, W. S., LAUNER, L., LINDENBERGER, U., Palotie, A., PEDERSEN, N. L., PENDLETON, N., PORTEOUS, D. J., RAIKKONEN, K., RAITAKARI, O. T., Ramirez, A., REINVANG, I., RUDAN, I., DAN, Rujescu, Schmidt, R., Schmidt, H., SCHOFIELD, P. W., STARR, J. M., STEEN, V. M., TROLLOR, J. N., TURNER, S. T., VAN DUIJN, C. M., VILLRINGER, A., WEINBERGER, D. R., WEIR, D. R., WILSON, J. F., Malhotra, A., MCINTOSH, A. M., GALE, C. R., SESHADRI, S., MOSLEY, T. H., Jr., BRESSLER, J., Lencz, T., DEARY, I. J., Bordeaux population health (BPH), and Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
VINTAGE, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, HEALTHY, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries)
Abstract

Christina M. Lill, who contributed to analysis of data, was inadvertently omitted from the author list in the originally published version of this article. This has now been corrected in both the PDF and HTML versions of the article.

Published
2019
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30. Erratum: Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium

Author

van Erp, T G M, Hibar, D P, Rasmussen, J M, Glahn, D C, Pearlson, G D, Andreassen, O A, Agartz, I, Westlye, L T, Haukvik, U K, Dale, A M, Melle, I, Hartberg, C B, Gruber, O, Kraemer, B, Zilles, D, Donohoe, G, Kelly, S, McDonald, C, Morris, D W, Cannon, D M, Corvin, A, Machielsen, M W J, Koenders, L, de Haan, L, Veltman, D J, Satterthwaite, T D, Wolf, D H, Gur, R C, Gur, R E, Potkin, S G, Mathalon, D H, Mueller, B A, Preda, A, Macciardi, F, Ehrlich, S, Walton, E, Hass, J, Calhoun, V D, Bockholt, H J, Sponheim, S R, Shoemaker, J M, van Haren, N E M, Pol, H E H, Ophoff, R A, Kahn, R S, Roiz-Santiañez, R, Crespo-Facorro, B, Wang, L, Alpert, K I, Jönsson, E G, Dimitrova, R, Bois, C, Whalley, H C, McIntosh, A M, Lawrie, S M, Hashimoto, R, Thompson, P M, and Turner, J A

Published
2016
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32. Widespread white matter microstructural differences in schizophrenia across 4322 individuals : Results from the ENIGMA Schizophrenia DTI Working Group

Author

Kelly, S., Jahanshad, N., Zalesky, A., Kochunov, P., Agartz, I., Alloza, C., Andreassen, O. A., Arango, C., Banaj, N., Bouix, S., Bousman, C. A., Brouwer, R. M., Bruggemann, J., Bustillo, J., Cahn, W., Calhoun, V., Cannon, D., Carr, V., Catts, S., Chen, J., Chen, J. X., Chen, X., Chiapponi, C., Cho, Kl K., Ciullo, V., Corvin, A. S., Crespo-Facorro, B., Cropley, V., De Rossi, P., Diaz-Caneja, C. M., Dickie, E. W., Ehrlich, S., Fan, F. M., Faskowitz, J., Fatouros-Bergman, H., Flyckt, L., Ford, J. M., Fouche, J. P., Fukunaga, M., Gill, M., Glahn, D. C., Gollub, R., Goudzwaard, E. D., Guo, H., Gur, R. E., Gur, R. C., Gurholt, T. P., Hashimoto, R., Hatton, S. N., Henskens, F. A., Hibar, D. P., Hickie, I. B., Hong, L. E., Horacek, J., Howells, F. M., Hulshoff Pol, H. E., Hyde, C. L., Isaev, D., Jablensky, A., Jansen, P. R., Janssen, J., Jönsson, E. G., Jung, L. A., Kahn, R. S., Kikinis, Z., Liu, K., Klauser, P., Knöchel, C., Kubicki, M., Lagopoulos, J., Langen, C., Lawrie, S., Lenroot, R. K., Lim, K. O., Lopez-Jaramillo, C., Lyall, A., Magnotta, V., Mandl, R. C.W., Mathalon, D. H., McCarley, R. W., McCarthy-Jones, S., McDonald, C., McEwen, S., McIntosh, A., Melicher, T., Mesholam-Gately, R. I., Michie, P. T., Mowry, B., Mueller, B. A., Newell, D. T., O'Donnell, P., Oertel-Knöchel, V., Oestreich, L., Paciga, S. A., Pantelis, C., Pasternak, O., Pearlson, G., Pellicano, G. R., Pereira, A., Pineda Zapata, J., Piras, F., Potkin, S. G., Preda, A., Rasser, P. E., Roalf, D. R., Roiz, R., Roos, A., Rotenberg, D., Satterthwaite, T. D., Savadjiev, P., Schall, U., Scott, R. J., Seal, M. L., Seidman, L. J., Shannon Weickert, C., Whelan, C. D., Shenton, M. E., Kwon, J. S., Spalletta, G., Spaniel, F., Sprooten, E., Stäblein, M., Stein, D. J., Sundram, S., Tan, Y., Tan, S., Tang, S., Temmingh, H. S., Westlye, L. T., Tønnesen, S., Tordesillas-Gutierrez, D., Doan, N. T., Vaidya, J., Van Haren, N. E.M., Vargas, C. D., Vecchio, D., Velakoulis, D., Voineskos, A., Voyvodic, J. Q., Wang, Z., Wan, P., Wei, D., Weickert, T. W., Whalley, H., White, T., Whitford, T. J., Wojcik, J. D., Xiang, H., Xie, Z., Yamamori, H., Yang, F., Yao, N., Zhang, G., Zhao, J., Van Erp, T. G.M., Turner, J., Thompson, P. M., Donohoe, G., Kelly, S., Jahanshad, N., Zalesky, A., Kochunov, P., Agartz, I., Alloza, C., Andreassen, O. A., Arango, C., Banaj, N., Bouix, S., Bousman, C. A., Brouwer, R. M., Bruggemann, J., Bustillo, J., Cahn, W., Calhoun, V., Cannon, D., Carr, V., Catts, S., Chen, J., Chen, J. X., Chen, X., Chiapponi, C., Cho, Kl K., Ciullo, V., Corvin, A. S., Crespo-Facorro, B., Cropley, V., De Rossi, P., Diaz-Caneja, C. M., Dickie, E. W., Ehrlich, S., Fan, F. M., Faskowitz, J., Fatouros-Bergman, H., Flyckt, L., Ford, J. M., Fouche, J. P., Fukunaga, M., Gill, M., Glahn, D. C., Gollub, R., Goudzwaard, E. D., Guo, H., Gur, R. E., Gur, R. C., Gurholt, T. P., Hashimoto, R., Hatton, S. N., Henskens, F. A., Hibar, D. P., Hickie, I. B., Hong, L. E., Horacek, J., Howells, F. M., Hulshoff Pol, H. E., Hyde, C. L., Isaev, D., Jablensky, A., Jansen, P. R., Janssen, J., Jönsson, E. G., Jung, L. A., Kahn, R. S., Kikinis, Z., Liu, K., Klauser, P., Knöchel, C., Kubicki, M., Lagopoulos, J., Langen, C., Lawrie, S., Lenroot, R. K., Lim, K. O., Lopez-Jaramillo, C., Lyall, A., Magnotta, V., Mandl, R. C.W., Mathalon, D. H., McCarley, R. W., McCarthy-Jones, S., McDonald, C., McEwen, S., McIntosh, A., Melicher, T., Mesholam-Gately, R. I., Michie, P. T., Mowry, B., Mueller, B. A., Newell, D. T., O'Donnell, P., Oertel-Knöchel, V., Oestreich, L., Paciga, S. A., Pantelis, C., Pasternak, O., Pearlson, G., Pellicano, G. R., Pereira, A., Pineda Zapata, J., Piras, F., Potkin, S. G., Preda, A., Rasser, P. E., Roalf, D. R., Roiz, R., Roos, A., Rotenberg, D., Satterthwaite, T. D., Savadjiev, P., Schall, U., Scott, R. J., Seal, M. L., Seidman, L. J., Shannon Weickert, C., Whelan, C. D., Shenton, M. E., Kwon, J. S., Spalletta, G., Spaniel, F., Sprooten, E., Stäblein, M., Stein, D. J., Sundram, S., Tan, Y., Tan, S., Tang, S., Temmingh, H. S., Westlye, L. T., Tønnesen, S., Tordesillas-Gutierrez, D., Doan, N. T., Vaidya, J., Van Haren, N. E.M., Vargas, C. D., Vecchio, D., Velakoulis, D., Voineskos, A., Voyvodic, J. Q., Wang, Z., Wan, P., Wei, D., Weickert, T. W., Whalley, H., White, T., Whitford, T. J., Wojcik, J. D., Xiang, H., Xie, Z., Yamamori, H., Yang, F., Yao, N., Zhang, G., Zhao, J., Van Erp, T. G.M., Turner, J., Thompson, P. M., and Donohoe, G.

Published
2018

33. Widespread white matter microstructural differences in schizophrenia across 4322 individuals: Results from the ENIGMA Schizophrenia DTI Working Group

Author

Onderzoeksgroep 1, Brain, Affectieve & Psychotische Med., Research Office, Onderzoek Bob Oranje, Onderzoeksgroep 11, Onderzoeksgroep 8, Onderzoeksgroep 4, Kelly, S., Jahanshad, N., Zalesky, A., Kochunov, P., Agartz, I., Alloza, C., Andreassen, O. A., Arango, C., Banaj, N., Bouix, S., Bousman, C. A., Brouwer, R. M., Bruggemann, J., Bustillo, J., Cahn, W., Calhoun, V., Cannon, D., Carr, V., Catts, S., Chen, J., Chen, J. X., Chen, X., Chiapponi, C., Cho, Kl K., Ciullo, V., Corvin, A. S., Crespo-Facorro, B., Cropley, V., De Rossi, P., Diaz-Caneja, C. M., Dickie, E. W., Ehrlich, S., Fan, F. M., Faskowitz, J., Fatouros-Bergman, H., Flyckt, L., Ford, J. M., Fouche, J. P., Fukunaga, M., Gill, M., Glahn, D. C., Gollub, R., Goudzwaard, E. D., Guo, H., Gur, R. E., Gur, R. C., Gurholt, T. P., Hashimoto, R., Hatton, S. N., Henskens, F. A., Hibar, D. P., Hickie, I. B., Hong, L. E., Horacek, J., Howells, F. M., Hulshoff Pol, H. E., Hyde, C. L., Isaev, D., Jablensky, A., Jansen, P. R., Janssen, J., Jönsson, E. G., Jung, L. A., Kahn, R. S., Kikinis, Z., Liu, K., Klauser, P., Knöchel, C., Kubicki, M., Lagopoulos, J., Langen, C., Lawrie, S., Lenroot, R. K., Lim, K. O., Lopez-Jaramillo, C., Lyall, A., Magnotta, V., Mandl, R. C.W., Mathalon, D. H., McCarley, R. W., McCarthy-Jones, S., McDonald, C., McEwen, S., McIntosh, A., Melicher, T., Mesholam-Gately, R. I., Michie, P. T., Mowry, B., Mueller, B. A., Newell, D. T., O'Donnell, P., Oertel-Knöchel, V., Oestreich, L., Paciga, S. A., Pantelis, C., Pasternak, O., Pearlson, G., Pellicano, G. R., Pereira, A., Pineda Zapata, J., Piras, F., Potkin, S. G., Preda, A., Rasser, P. E., Roalf, D. R., Roiz, R., Roos, A., Rotenberg, D., Satterthwaite, T. D., Savadjiev, P., Schall, U., Scott, R. J., Seal, M. L., Seidman, L. J., Shannon Weickert, C., Whelan, C. D., Shenton, M. E., Kwon, J. S., Spalletta, G., Spaniel, F., Sprooten, E., Stäblein, M., Stein, D. J., Sundram, S., Tan, Y., Tan, S., Tang, S., Temmingh, H. S., Westlye, L. T., Tønnesen, S., Tordesillas-Gutierrez, D., Doan, N. T., Vaidya, J., Van Haren, N. E.M., Vargas, C. D., Vecchio, D., Velakoulis, D., Voineskos, A., Voyvodic, J. Q., Wang, Z., Wan, P., Wei, D., Weickert, T. W., Whalley, H., White, T., Whitford, T. J., Wojcik, J. D., Xiang, H., Xie, Z., Yamamori, H., Yang, F., Yao, N., Zhang, G., Zhao, J., Van Erp, T. G.M., Turner, J., Thompson, P. M., Donohoe, G., Onderzoeksgroep 1, Brain, Affectieve & Psychotische Med., Research Office, Onderzoek Bob Oranje, Onderzoeksgroep 11, Onderzoeksgroep 8, Onderzoeksgroep 4, Kelly, S., Jahanshad, N., Zalesky, A., Kochunov, P., Agartz, I., Alloza, C., Andreassen, O. A., Arango, C., Banaj, N., Bouix, S., Bousman, C. A., Brouwer, R. M., Bruggemann, J., Bustillo, J., Cahn, W., Calhoun, V., Cannon, D., Carr, V., Catts, S., Chen, J., Chen, J. X., Chen, X., Chiapponi, C., Cho, Kl K., Ciullo, V., Corvin, A. S., Crespo-Facorro, B., Cropley, V., De Rossi, P., Diaz-Caneja, C. M., Dickie, E. W., Ehrlich, S., Fan, F. M., Faskowitz, J., Fatouros-Bergman, H., Flyckt, L., Ford, J. M., Fouche, J. P., Fukunaga, M., Gill, M., Glahn, D. C., Gollub, R., Goudzwaard, E. D., Guo, H., Gur, R. E., Gur, R. C., Gurholt, T. P., Hashimoto, R., Hatton, S. N., Henskens, F. A., Hibar, D. P., Hickie, I. B., Hong, L. E., Horacek, J., Howells, F. M., Hulshoff Pol, H. E., Hyde, C. L., Isaev, D., Jablensky, A., Jansen, P. R., Janssen, J., Jönsson, E. G., Jung, L. A., Kahn, R. S., Kikinis, Z., Liu, K., Klauser, P., Knöchel, C., Kubicki, M., Lagopoulos, J., Langen, C., Lawrie, S., Lenroot, R. K., Lim, K. O., Lopez-Jaramillo, C., Lyall, A., Magnotta, V., Mandl, R. C.W., Mathalon, D. H., McCarley, R. W., McCarthy-Jones, S., McDonald, C., McEwen, S., McIntosh, A., Melicher, T., Mesholam-Gately, R. I., Michie, P. T., Mowry, B., Mueller, B. A., Newell, D. T., O'Donnell, P., Oertel-Knöchel, V., Oestreich, L., Paciga, S. A., Pantelis, C., Pasternak, O., Pearlson, G., Pellicano, G. R., Pereira, A., Pineda Zapata, J., Piras, F., Potkin, S. G., Preda, A., Rasser, P. E., Roalf, D. R., Roiz, R., Roos, A., Rotenberg, D., Satterthwaite, T. D., Savadjiev, P., Schall, U., Scott, R. J., Seal, M. L., Seidman, L. J., Shannon Weickert, C., Whelan, C. D., Shenton, M. E., Kwon, J. S., Spalletta, G., Spaniel, F., Sprooten, E., Stäblein, M., Stein, D. J., Sundram, S., Tan, Y., Tan, S., Tang, S., Temmingh, H. S., Westlye, L. T., Tønnesen, S., Tordesillas-Gutierrez, D., Doan, N. T., Vaidya, J., Van Haren, N. E.M., Vargas, C. D., Vecchio, D., Velakoulis, D., Voineskos, A., Voyvodic, J. Q., Wang, Z., Wan, P., Wei, D., Weickert, T. W., Whalley, H., White, T., Whitford, T. J., Wojcik, J. D., Xiang, H., Xie, Z., Yamamori, H., Yang, F., Yao, N., Zhang, G., Zhao, J., Van Erp, T. G.M., Turner, J., Thompson, P. M., and Donohoe, G.

Published
2018

34. Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

Author

Davies, G., Lam, M., Harris, S. E., Trampush, J. W., Luciano, M., Hill, W. D., Hagenaars, S. P., Ritchie, S. J., Marioni, R. E., Fawns-Ritchie, C., Liewald, D. C. M., Okely, J. A., Ahola-Olli, A. V., Barnes, C. L. K., Bertram, L., Bis, J. C., Burdick, K. E., Christoforou, A., Derosse, P., Djurovic, S., Espeseth, T., Giakoumaki, S., Giddaluru, S., Gustavson, D. E., Hayward, C., Hofer, E., Ikram, M. A., Karlsson, R., Knowles, E., Lahti, J., Leber, M., Li, S., Mather, K. A., Melle, I., Morris, D., Oldmeadow, C., Palviainen, T., Payton, A., Pazoki, R., Petrovic, K., Reynolds, C. A., Sargurupremraj, M., Scholz, M., Smith, J. A., Smith, A. V., Terzikhan, N., Thalamuthu, A., Trompet, S., Van Der Lee, S. J., Ware, E. B., Windham, B. G., Wright, M. J., Yang, J., Yu, J., Ames, D., Amin, N., Amouyel, P., Andreassen, O. A., Armstrong, N. J., Assareh, A. A., Attia, J. R., Attix, D., Avramopoulos, D., Bennett, D. A., Böhmer, A. C., Boyle, P. A., Brodaty, H., Campbell, H., Cannon, T. D., Cirulli, E. T., Congdon, E., Conley, E. D., Corley, J., Cox, S. R., Dale, A. M., Dehghan, A., Dick, D., Dickinson, D., Eriksson, J. G., Evangelou, E., Faul, J. D., Ford, I., Freimer, N. A., Gao, H., Giegling, I., Gillespie, N. A., Gordon, S. D., Gottesman, R. F., Griswold, M. E., Gudnason, V., Harris, T. B., Hartmann, A. M., Hatzimanolis, A., Heiss, G., Holliday, E. G., Joshi, P. K., Kähönen, M., Kardia, S. L. R., Karlsson, Ida K., Kleineidam, L., Knopman, D. S., Kochan, N. A., Konte, B., Kwok, J. B., Le Hellard, S., Lee, T., Lehtimäki, T., Li, S. -C, Liu, T., Koini, M., London, E., Longstreth, W.T., Jr., Lopez, O. L., Loukola, A., Luck, T., Lundervold, A. J., Lundquist, A., Lyytikäinen, L. -P, Martin, N. G., Montgomery, G. W., Murray, A. D., Need, A. C., Noordam, R., Nyberg, L., Ollier, W., Papenberg, G., Pattie, A., Polasek, O., Poldrack, R. A., Psaty, B. M., Reppermund, S., Riedel-Heller, S. G., Rose, R. J., Rotter, J. I., Roussos, P., Rovio, S. P., Saba, Y., Sabb, F. W., Sachdev, P. S., Satizabal, C. L., Schmid, M., Scott, R. J., Scult, M. A., Simino, J., Slagboom, P. E., Smyrnis, N., Soumaré, A., Stefanis, N. C., Stott, D. J., Straub, R. E., Sundet, K., Taylor, A. M., Taylor, K. D., Tzoulaki, I., Tzourio, C., Uitterlinden, A., Vitart, V., Voineskos, A. N., Kaprio, J., Wagner, M., Wagner, H., Weinhold, L., Wen, K. H., Widen, E., Yang, Q., Zhao, W., Adams, H. H. H., Arking, D. E., Bilder, R. M., Bitsios, P., Boerwinkle, E., Chiba-Falek, O., Corvin, A., De Jager, P. L., Debette, S., Donohoe, G., Elliott, P., Fitzpatrick, A. L., Gill, M., Glahn, D. C., Hägg, S., Hansell, N. K., Hariri, A. R., Ikram, M. K., Jukema, J. W., Vuoksimaa, E., Keller, M. C., Kremen, W. S., Launer, L., Lindenberger, U., Palotie, A., Pedersen, N. L., Pendleton, N., Porteous, D. J., Räikkönen, K., Raitakari, O. T., Ramirez, A., Reinvang, I., Rudan, I., Rujescu, D., Schmidt, R., Schmidt, H., Schofield, P. W., Schofield, P. R., Starr, J. M., Steen, V. M., Trollor, J. N., Turner, S. T., Van Duijn, C. M., Villringer, A., Weinberger, D. R., Weir, D. R., Wilson, J. F., Malhotra, A., McIntosh, A. M., Gale, C. R., Seshadri, S., Mosley, T.H., Jr., Bressler, J., Lencz, T., Deary, I. J., Davies, G., Lam, M., Harris, S. E., Trampush, J. W., Luciano, M., Hill, W. D., Hagenaars, S. P., Ritchie, S. J., Marioni, R. E., Fawns-Ritchie, C., Liewald, D. C. M., Okely, J. A., Ahola-Olli, A. V., Barnes, C. L. K., Bertram, L., Bis, J. C., Burdick, K. E., Christoforou, A., Derosse, P., Djurovic, S., Espeseth, T., Giakoumaki, S., Giddaluru, S., Gustavson, D. E., Hayward, C., Hofer, E., Ikram, M. A., Karlsson, R., Knowles, E., Lahti, J., Leber, M., Li, S., Mather, K. A., Melle, I., Morris, D., Oldmeadow, C., Palviainen, T., Payton, A., Pazoki, R., Petrovic, K., Reynolds, C. A., Sargurupremraj, M., Scholz, M., Smith, J. A., Smith, A. V., Terzikhan, N., Thalamuthu, A., Trompet, S., Van Der Lee, S. J., Ware, E. B., Windham, B. G., Wright, M. J., Yang, J., Yu, J., Ames, D., Amin, N., Amouyel, P., Andreassen, O. A., Armstrong, N. J., Assareh, A. A., Attia, J. R., Attix, D., Avramopoulos, D., Bennett, D. A., Böhmer, A. C., Boyle, P. A., Brodaty, H., Campbell, H., Cannon, T. D., Cirulli, E. T., Congdon, E., Conley, E. D., Corley, J., Cox, S. R., Dale, A. M., Dehghan, A., Dick, D., Dickinson, D., Eriksson, J. G., Evangelou, E., Faul, J. D., Ford, I., Freimer, N. A., Gao, H., Giegling, I., Gillespie, N. A., Gordon, S. D., Gottesman, R. F., Griswold, M. E., Gudnason, V., Harris, T. B., Hartmann, A. M., Hatzimanolis, A., Heiss, G., Holliday, E. G., Joshi, P. K., Kähönen, M., Kardia, S. L. R., Karlsson, Ida K., Kleineidam, L., Knopman, D. S., Kochan, N. A., Konte, B., Kwok, J. B., Le Hellard, S., Lee, T., Lehtimäki, T., Li, S. -C, Liu, T., Koini, M., London, E., Longstreth, W.T., Jr., Lopez, O. L., Loukola, A., Luck, T., Lundervold, A. J., Lundquist, A., Lyytikäinen, L. -P, Martin, N. G., Montgomery, G. W., Murray, A. D., Need, A. C., Noordam, R., Nyberg, L., Ollier, W., Papenberg, G., Pattie, A., Polasek, O., Poldrack, R. A., Psaty, B. M., Reppermund, S., Riedel-Heller, S. G., Rose, R. J., Rotter, J. I., Roussos, P., Rovio, S. P., Saba, Y., Sabb, F. W., Sachdev, P. S., Satizabal, C. L., Schmid, M., Scott, R. J., Scult, M. A., Simino, J., Slagboom, P. E., Smyrnis, N., Soumaré, A., Stefanis, N. C., Stott, D. J., Straub, R. E., Sundet, K., Taylor, A. M., Taylor, K. D., Tzoulaki, I., Tzourio, C., Uitterlinden, A., Vitart, V., Voineskos, A. N., Kaprio, J., Wagner, M., Wagner, H., Weinhold, L., Wen, K. H., Widen, E., Yang, Q., Zhao, W., Adams, H. H. H., Arking, D. E., Bilder, R. M., Bitsios, P., Boerwinkle, E., Chiba-Falek, O., Corvin, A., De Jager, P. L., Debette, S., Donohoe, G., Elliott, P., Fitzpatrick, A. L., Gill, M., Glahn, D. C., Hägg, S., Hansell, N. K., Hariri, A. R., Ikram, M. K., Jukema, J. W., Vuoksimaa, E., Keller, M. C., Kremen, W. S., Launer, L., Lindenberger, U., Palotie, A., Pedersen, N. L., Pendleton, N., Porteous, D. J., Räikkönen, K., Raitakari, O. T., Ramirez, A., Reinvang, I., Rudan, I., Rujescu, D., Schmidt, R., Schmidt, H., Schofield, P. W., Schofield, P. R., Starr, J. M., Steen, V. M., Trollor, J. N., Turner, S. T., Van Duijn, C. M., Villringer, A., Weinberger, D. R., Weir, D. R., Wilson, J. F., Malhotra, A., McIntosh, A. M., Gale, C. R., Seshadri, S., Mosley, T.H., Jr., Bressler, J., Lencz, T., and Deary, I. J.

Abstract

General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16-102) and find 148 genome-wide significant independent loci (P < 5 × 10-8) associated with general cognitive function. Within the novel genetic loci are variants associated with neurodegenerative and neurodevelopmental disorders, physical and psychiatric illnesses, and brain structure. Gene-based analyses find 709 genes associated with general cognitive function. Expression levels across the cortex are associated with general cognitive function. Using polygenic scores, up to 4.3% of variance in general cognitive function is predicted in independent samples. We detect significant genetic overlap between general cognitive function, reaction time, and many health variables including eyesight, hypertension, and longevity. In conclusion we identify novel genetic loci and pathways contributing to the heritability of general cognitive function.

Published
2018
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35. Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence

Author

Savage, J. E., Jansen, P. R., Stringer, S., Watanabe, K., Bryois, J., De Leeuw, C. A., Nagel, M., Awasthi, S., Barr, P. B., Coleman, J. R. I., Grasby, K. L., Hammerschlag, A. R., Kaminski, J. A., Karlsson, R., Krapohl, E., Lam, M., Nygaard, M., Reynolds, C. A., Trampush, J. W., Young, H., Zabaneh, D., Hägg, S., Hansell, N. K., Karlsson, Ida K., Linnarsson, S., Montgomery, G. W., Muñoz-Manchado, A. B., Quinlan, E. B., Schumann, G., Skene, N. G., Webb, B. T., White, T., Arking, D. E., Avramopoulos, D., Bilder, R. M., Bitsios, P., Burdick, K. E., Cannon, T. D., Chiba-Falek, O., Christoforou, A., Cirulli, E. T., Congdon, E., Corvin, A., Davies, G., Deary, I. J., Derosse, P., Dickinson, D., Djurovic, S., Donohoe, G., Conley, E. D., Eriksson, J. G., Espeseth, T., Freimer, N. A., Giakoumaki, S., Giegling, I., Gill, M., Glahn, D. C., Hariri, A. R., Hatzimanolis, A., Keller, M. C., Knowles, E., Koltai, D., Konte, B., Lahti, J., Le Hellard, S., Lencz, T., Liewald, D. C., London, E., Lundervold, A. J., Malhotra, A. K., Melle, I., Morris, D., Need, A. C., Ollier, W., Palotie, A., Payton, A., Pendleton, N., Poldrack, R. A., Räikkönen, K., Reinvang, I., Roussos, P., Rujescu, D., Sabb, F. W., Scult, M. A., Smeland, O. B., Smyrnis, N., Starr, J. M., Steen, V. M., Stefanis, N. C., Straub, R. E., Sundet, K., Tiemeier, H., Voineskos, A. N., Weinberger, D. R., Widen, E., Yu, J., Abecasis, G., Andreassen, O. A., Breen, G., Christiansen, L., Debrabant, B., Dick, D. M., Heinz, A., Hjerling-Leffler, J., Ikram, M. A., Kendler, K. S., Martin, N. G., Medland, S. E., Pedersen, N. L., Plomin, R., Polderman, T. J. C., Ripke, S., Van Der Sluis, S., Sullivan, P. F., Vrieze, S. I., Wright, M. J., Posthuma, D., Savage, J. E., Jansen, P. R., Stringer, S., Watanabe, K., Bryois, J., De Leeuw, C. A., Nagel, M., Awasthi, S., Barr, P. B., Coleman, J. R. I., Grasby, K. L., Hammerschlag, A. R., Kaminski, J. A., Karlsson, R., Krapohl, E., Lam, M., Nygaard, M., Reynolds, C. A., Trampush, J. W., Young, H., Zabaneh, D., Hägg, S., Hansell, N. K., Karlsson, Ida K., Linnarsson, S., Montgomery, G. W., Muñoz-Manchado, A. B., Quinlan, E. B., Schumann, G., Skene, N. G., Webb, B. T., White, T., Arking, D. E., Avramopoulos, D., Bilder, R. M., Bitsios, P., Burdick, K. E., Cannon, T. D., Chiba-Falek, O., Christoforou, A., Cirulli, E. T., Congdon, E., Corvin, A., Davies, G., Deary, I. J., Derosse, P., Dickinson, D., Djurovic, S., Donohoe, G., Conley, E. D., Eriksson, J. G., Espeseth, T., Freimer, N. A., Giakoumaki, S., Giegling, I., Gill, M., Glahn, D. C., Hariri, A. R., Hatzimanolis, A., Keller, M. C., Knowles, E., Koltai, D., Konte, B., Lahti, J., Le Hellard, S., Lencz, T., Liewald, D. C., London, E., Lundervold, A. J., Malhotra, A. K., Melle, I., Morris, D., Need, A. C., Ollier, W., Palotie, A., Payton, A., Pendleton, N., Poldrack, R. A., Räikkönen, K., Reinvang, I., Roussos, P., Rujescu, D., Sabb, F. W., Scult, M. A., Smeland, O. B., Smyrnis, N., Starr, J. M., Steen, V. M., Stefanis, N. C., Straub, R. E., Sundet, K., Tiemeier, H., Voineskos, A. N., Weinberger, D. R., Widen, E., Yu, J., Abecasis, G., Andreassen, O. A., Breen, G., Christiansen, L., Debrabant, B., Dick, D. M., Heinz, A., Hjerling-Leffler, J., Ikram, M. A., Kendler, K. S., Martin, N. G., Medland, S. E., Pedersen, N. L., Plomin, R., Polderman, T. J. C., Ripke, S., Van Der Sluis, S., Sullivan, P. F., Vrieze, S. I., Wright, M. J., and Posthuma, D.

Abstract

Intelligence is highly heritable 1 and a major determinant of human health and well-being 2 . Recent genome-wide meta-analyses have identified 24 genomic loci linked to variation in intelligence 3-7, but much about its genetic underpinnings remains to be discovered. Here, we present a large-scale genetic association study of intelligence (n = 269,867), identifying 205 associated genomic loci (190 new) and 1,016 genes (939 new) via positional mapping, expression quantitative trait locus (eQTL) mapping, chromatin interaction mapping, and gene-based association analysis. We find enrichment of genetic effects in conserved and coding regions and associations with 146 nonsynonymous exonic variants. Associated genes are strongly expressed in the brain, specifically in striatal medium spiny neurons and hippocampal pyramidal neurons. Gene set analyses implicate pathways related to nervous system development and synaptic structure. We confirm previous strong genetic correlations with multiple health-related outcomes, and Mendelian randomization analysis results suggest protective effects of intelligence for Alzheimer's disease and ADHD and bidirectional causation with pleiotropic effects for schizophrenia. These results are a major step forward in understanding the neurobiology of cognitive function as well as genetically related neurological and psychiatric disorders.

Published
2018
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37. GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium

Author

Trampush, J. W. Yang, M. L. Z. Yu, J. Knowles, E. and Davies, G. Liewald, D. C. Starr, J. M. Djurovic, S. and Melle, I. Sundet, K. Christoforou, A. Reinvang, I. and DeRosse, P. Lundervold, A. J. Steen, V. M. Espeseth, T. and Raikkonen, K. Widen, E. Palotie, A. Eriksson, J. G. and Giegling, I. Konte, B. Roussos, P. Giakoumaki, S. and Burdick, K. E. Payton, A. Ollier, W. Horan, M. and Chiba-Falek, O. Attix, D. K. Need, A. C. Cirulli, E. T. and Voineskos, A. N. Stefanis, N. C. Avramopoulos, D. and Hatzimanolis, A. Arking, D. E. Smyrnis, N. Bilder, R. M. and Freimer, N. A. Cannon, T. D. London, E. Poldrack, R. A. and Sabb, F. W. Congdon, E. Conley, E. D. Scult, M. A. and Dickinson, D. Straub, R. E. Donohoe, G. Morris, D. and Corvin, A. Gill, M. Hariri, A. R. Weinberger, D. R. and Pendleton, N. Bitsios, P. Rujescu, D. Lahti, J. Le Hellard, S. Keller, M. C. Andreassen, O. A. Deary, I. J. and Glahn, D. C. Malhotra, A. K. Lencz, T.

Abstract

The complex nature of human cognition has resulted in cognitive genomics lagging behind many other fields in terms of gene discovery using genome-wide association study (GWAS) methods. In an attempt to overcome these barriers, the current study utilized GWAS meta-analysis to examine the association of common genetic variation (similar to 8M single-nucleotide polymorphisms (SNP) with minor allele frequency >= 1%) to general cognitive function in a sample of 35 298 healthy individuals of European ancestry across 24 cohorts in the Cognitive Genomics Consortium (COGENT). In addition, we utilized individual SNP lookups and polygenic score analyses to identify genetic overlap with other relevant neurobehavioral phenotypes. Our primary GWAS meta-analysis identified two novel SNP loci (top SNPs: rs76114856 in the CENPO gene on chromosome 2 and rs6669072 near LOC105378853 on chromosome 1) associated with cognitive performance at the genome-wide significance level (P

Published
2017

38. Erratum:Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium

Author

van Erp, T. G M, Hibar, D. P., Rasmussen, J. M., Glahn, D. C., Pearlson, G. D., Andreassen, O. A., Agartz, I., Westlye, L. T., Haukvik, U. K., Dale, A. M., Melle, I., Hartberg, C. B., Gruber, O., Kraemer, B., Zilles, D., Donohoe, G., Kelly, S., McDonald, C., Morris, D. W., Cannon, D. M., Corvin, A., Machielsen, M. W J, Koenders, L., de Haan, L., Veltman, D. J., Satterthwaite, T. D., Wolf, D. H., Gur, R. C., Gur, R. E., Potkin, S. G., Mathalon, D. H., Mueller, B. A., Preda, A., Macciardi, F., Ehrlich, S., Walton, E., Hass, J., Calhoun, V. D., Bockholt, H. J., Sponheim, S. R., Shoemaker, J. M., van Haren, N. E M, Hulshoff Pol, H.E., Ophoff, R. A., Kahn, R. S., Roiz-Santiañez, R., Crespo-Facorro, B., Wang, L., Alpert, K. I., Jönsson, E. G., Dimitrova, R., Bois, C., Whalley, H. C., McIntosh, A. M., Lawrie, S. M., Hashimoto, R., Thompson, P. M., and Turner, J. A.

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Published Erratum, Molecular Biology
Published
2016

39. Widespread white matter microstructural differences in schizophrenia across 4322 individuals: results from the ENIGMA Schizophrenia DTI Working Group

Author

Kelly, S, primary, Jahanshad, N, additional, Zalesky, A, additional, Kochunov, P, additional, Agartz, I, additional, Alloza, C, additional, Andreassen, O A, additional, Arango, C, additional, Banaj, N, additional, Bouix, S, additional, Bousman, C A, additional, Brouwer, R M, additional, Bruggemann, J, additional, Bustillo, J, additional, Cahn, W, additional, Calhoun, V, additional, Cannon, D, additional, Carr, V, additional, Catts, S, additional, Chen, J, additional, Chen, J-x, additional, Chen, X, additional, Chiapponi, C, additional, Cho, Kl K, additional, Ciullo, V, additional, Corvin, A S, additional, Crespo-Facorro, B, additional, Cropley, V, additional, De Rossi, P, additional, Diaz-Caneja, C M, additional, Dickie, E W, additional, Ehrlich, S, additional, Fan, F-m, additional, Faskowitz, J, additional, Fatouros-Bergman, H, additional, Flyckt, L, additional, Ford, J M, additional, Fouche, J-P, additional, Fukunaga, M, additional, Gill, M, additional, Glahn, D C, additional, Gollub, R, additional, Goudzwaard, E D, additional, Guo, H, additional, Gur, R E, additional, Gur, R C, additional, Gurholt, T P, additional, Hashimoto, R, additional, Hatton, S N, additional, Henskens, F A, additional, Hibar, D P, additional, Hickie, I B, additional, Hong, L E, additional, Horacek, J, additional, Howells, F M, additional, Hulshoff Pol, H E, additional, Hyde, C L, additional, Isaev, D, additional, Jablensky, A, additional, Jansen, P R, additional, Janssen, J, additional, Jönsson, E G, additional, Jung, L A, additional, Kahn, R S, additional, Kikinis, Z, additional, Liu, K, additional, Klauser, P, additional, Knöchel, C, additional, Kubicki, M, additional, Lagopoulos, J, additional, Langen, C, additional, Lawrie, S, additional, Lenroot, R K, additional, Lim, K O, additional, Lopez-Jaramillo, C, additional, Lyall, A, additional, Magnotta, V, additional, Mandl, R C W, additional, Mathalon, D H, additional, McCarley, R W, additional, McCarthy-Jones, S, additional, McDonald, C, additional, McEwen, S, additional, McIntosh, A, additional, Melicher, T, additional, Mesholam-Gately, R I, additional, Michie, P T, additional, Mowry, B, additional, Mueller, B A, additional, Newell, D T, additional, O'Donnell, P, additional, Oertel-Knöchel, V, additional, Oestreich, L, additional, Paciga, S A, additional, Pantelis, C, additional, Pasternak, O, additional, Pearlson, G, additional, Pellicano, G R, additional, Pereira, A, additional, Pineda Zapata, J, additional, Piras, F, additional, Potkin, S G, additional, Preda, A, additional, Rasser, P E, additional, Roalf, D R, additional, Roiz, R, additional, Roos, A, additional, Rotenberg, D, additional, Satterthwaite, T D, additional, Savadjiev, P, additional, Schall, U, additional, Scott, R J, additional, Seal, M L, additional, Seidman, L J, additional, Shannon Weickert, C, additional, Whelan, C D, additional, Shenton, M E, additional, Kwon, J S, additional, Spalletta, G, additional, Spaniel, F, additional, Sprooten, E, additional, Stäblein, M, additional, Stein, D J, additional, Sundram, S, additional, Tan, Y, additional, Tan, S, additional, Tang, S, additional, Temmingh, H S, additional, Westlye, L T, additional, Tønnesen, S, additional, Tordesillas-Gutierrez, D, additional, Doan, N T, additional, Vaidya, J, additional, van Haren, N E M, additional, Vargas, C D, additional, Vecchio, D, additional, Velakoulis, D, additional, Voineskos, A, additional, Voyvodic, J Q, additional, Wang, Z, additional, Wan, P, additional, Wei, D, additional, Weickert, T W, additional, Whalley, H, additional, White, T, additional, Whitford, T J, additional, Wojcik, J D, additional, Xiang, H, additional, Xie, Z, additional, Yamamori, H, additional, Yang, F, additional, Yao, N, additional, Zhang, G, additional, Zhao, J, additional, van Erp, T G M, additional, Turner, J, additional, Thompson, P M, additional, and Donohoe, G, additional

Published
2017
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40. GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function

Author

University of Helsinki, Medicum, University of Helsinki, Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Clinicum, University of Helsinki, Helsinki Collegium for Advanced Studies, Trampush, J. W., Yang, M. L. Z., Yu, J., Knowles, E., Davies, G., Liewald, D. C., Starr, J. M., Djurovic, S., Melle, I., Sundet, K., Christoforou, A., Reinvang, I., DeRosse, P., Lundervold, A. J., Steen, V. M., Espeseth, T., Räikkönen, Katri, Widen, E., Palotie, A., Eriksson, J. G., Giegling, I., Konte, B., Roussos, P., Giakoumaki, S., Burdick, K. E., Payton, A., Ollier, W., Horan, M., Chiba-Falek, O., Attix, D. K., Need, A. C., Cirulli, E. T., Voineskos, A. N., Stefanis, N. C., Avramopoulos, D., Hatzimanolis, A., Arking, D. E., Smyrnis, N., Bilder, R. M., Freimer, N. A., Cannon, T. D., London, E., Poldrack, R. A., Sabb, F. W., Congdon, E., Conley, E. D., Scult, M. A., Dickinson, D., Straub, R. E., Donohoe, G., Morris, D., Corvin, A., Gill, M., Hariri, A. R., Weinberger, D. R., Pendleton, N., Bitsios, P., Rujescu, D., Lahti, J., Le Hellard, S., Keller, M. C., Andreassen, O. A., Deary, I. J., Glahn, D. C., Malhotra, A. K., Lencz, T., University of Helsinki, Medicum, University of Helsinki, Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Clinicum, University of Helsinki, Helsinki Collegium for Advanced Studies, Trampush, J. W., Yang, M. L. Z., Yu, J., Knowles, E., Davies, G., Liewald, D. C., Starr, J. M., Djurovic, S., Melle, I., Sundet, K., Christoforou, A., Reinvang, I., DeRosse, P., Lundervold, A. J., Steen, V. M., Espeseth, T., Räikkönen, Katri, Widen, E., Palotie, A., Eriksson, J. G., Giegling, I., Konte, B., Roussos, P., Giakoumaki, S., Burdick, K. E., Payton, A., Ollier, W., Horan, M., Chiba-Falek, O., Attix, D. K., Need, A. C., Cirulli, E. T., Voineskos, A. N., Stefanis, N. C., Avramopoulos, D., Hatzimanolis, A., Arking, D. E., Smyrnis, N., Bilder, R. M., Freimer, N. A., Cannon, T. D., London, E., Poldrack, R. A., Sabb, F. W., Congdon, E., Conley, E. D., Scult, M. A., Dickinson, D., Straub, R. E., Donohoe, G., Morris, D., Corvin, A., Gill, M., Hariri, A. R., Weinberger, D. R., Pendleton, N., Bitsios, P., Rujescu, D., Lahti, J., Le Hellard, S., Keller, M. C., Andreassen, O. A., Deary, I. J., Glahn, D. C., Malhotra, A. K., and Lencz, T.

Abstract

The complex nature of human cognition has resulted in cognitive genomics lagging behind many other fields in terms of gene discovery using genome-wide association study (GWAS) methods. In an attempt to overcome these barriers, the current study utilized GWAS meta-analysis to examine the association of common genetic variation (similar to 8M single-nucleotide polymorphisms (SNP) with minor allele frequency >= 1%) to general cognitive function in a sample of 35 298 healthy individuals of European ancestry across 24 cohorts in the Cognitive Genomics Consortium (COGENT). In addition, we utilized individual SNP lookups and polygenic score analyses to identify genetic overlap with other relevant neurobehavioral phenotypes. Our primary GWAS meta-analysis identified two novel SNP loci (top SNPs: rs76114856 in the CENPO gene on chromosome 2 and rs6669072 near LOC105378853 on chromosome 1) associated with cognitive performance at the genome-wide significance level (P

Published
2017

41. Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium

Author

van Erp, T. G M, Hibar, D. P., Rasmussen, J. M., Glahn, D. C., Pearlson, G. D., Andreassen, O. A., Agartz, I., Westlye, L. T., Haukvik, U. K., Dale, A. M., Melle, I., Hartberg, C. B., Gruber, O., Kraemer, B., Zilles, D., Donohoe, G., Kelly, S., McDonald, C., Morris, D. W., Cannon, D. M., Corvin, A., Machielsen, M. W J, Koenders, L., de Haan, L., Veltman, D. J., Satterthwaite, T. D., Wolf, D. H., Gur, R. C., Gur, R. E., Potkin, S. G., Mathalon, D. H., Mueller, B. A., Preda, A., Macciardi, F., Ehrlich, S., Walton, E., Hass, J., Calhoun, V. D., Bockholt, H. J., Sponheim, S. R., Shoemaker, J. M., van Haren, N. E M, Pol, H. E H, Ophoff, R. A., Kahn, R. S., Roiz-Santiañez, R., Crespo-Facorro, B., Wang, L., Alpert, K. I., Jönsson, E. G., Dimitrova, R., Bois, C., Whalley, H. C., McIntosh, A. M., Lawrie, S. M., Hashimoto, R., Thompson, P. M., Turner, J. A., van Erp, T. G M, Hibar, D. P., Rasmussen, J. M., Glahn, D. C., Pearlson, G. D., Andreassen, O. A., Agartz, I., Westlye, L. T., Haukvik, U. K., Dale, A. M., Melle, I., Hartberg, C. B., Gruber, O., Kraemer, B., Zilles, D., Donohoe, G., Kelly, S., McDonald, C., Morris, D. W., Cannon, D. M., Corvin, A., Machielsen, M. W J, Koenders, L., de Haan, L., Veltman, D. J., Satterthwaite, T. D., Wolf, D. H., Gur, R. C., Gur, R. E., Potkin, S. G., Mathalon, D. H., Mueller, B. A., Preda, A., Macciardi, F., Ehrlich, S., Walton, E., Hass, J., Calhoun, V. D., Bockholt, H. J., Sponheim, S. R., Shoemaker, J. M., van Haren, N. E M, Pol, H. E H, Ophoff, R. A., Kahn, R. S., Roiz-Santiañez, R., Crespo-Facorro, B., Wang, L., Alpert, K. I., Jönsson, E. G., Dimitrova, R., Bois, C., Whalley, H. C., McIntosh, A. M., Lawrie, S. M., Hashimoto, R., Thompson, P. M., and Turner, J. A.

Published
2016

42. Subcortical volumetric abnormalities in bipolar disorder

Author

Hibar, D. P., Westlye, L. T., Van Erp, T. G M, Rasmussen, J., Leonardo, C. D., Faskowitz, J., Haukvik, U. K., Hartberg, C. B., Doan, N. T., Agartz, I., Dale, A. M., Gruber, O., Krämer, B., Trost, S., Liberg, B., Abé, C., Ekman, C. J., Ingvar, M., Landén, M., Fears, S. C., Freimer, N. B., Bearden, C. E., Sprooten, E., Glahn, D. C., Pearlson, G. D., Emsell, L., Kenney, J., Scanlon, C., McDonald, C., Cannon, D. M., Almeida, J., Versace, A., Caseras, X., Lawrence, N. S., Phillips, M. L., Dima, D., Delvecchio, G., Frangou, S., Satterthwaite, T. D., Wolf, D., Houenou, J., Henry, C., Malt, U. F., BØen, E., Elvs'shagen, T., Young, A. H., Lloyd, A. J., Goodwin, G. M., Mackay, C. E., Bourne, C., Bilderbeck, A., Abramovic, L., Boks, M. P., Van Haren, N. E M, Ophoff, R. A., Kahn, R. S., Bauer, M., Pfennig, A., Alda, M., Hajek, T., Mwangi, B., Soares, J. C., Nickson, T., Dimitrova, R., Sussmann, J. E., Hagenaars, S., Whalley, H. C., McIntosh, A. M., Thompson, P. M., Andreassen, O. A., Hibar, D. P., Westlye, L. T., Van Erp, T. G M, Rasmussen, J., Leonardo, C. D., Faskowitz, J., Haukvik, U. K., Hartberg, C. B., Doan, N. T., Agartz, I., Dale, A. M., Gruber, O., Krämer, B., Trost, S., Liberg, B., Abé, C., Ekman, C. J., Ingvar, M., Landén, M., Fears, S. C., Freimer, N. B., Bearden, C. E., Sprooten, E., Glahn, D. C., Pearlson, G. D., Emsell, L., Kenney, J., Scanlon, C., McDonald, C., Cannon, D. M., Almeida, J., Versace, A., Caseras, X., Lawrence, N. S., Phillips, M. L., Dima, D., Delvecchio, G., Frangou, S., Satterthwaite, T. D., Wolf, D., Houenou, J., Henry, C., Malt, U. F., BØen, E., Elvs'shagen, T., Young, A. H., Lloyd, A. J., Goodwin, G. M., Mackay, C. E., Bourne, C., Bilderbeck, A., Abramovic, L., Boks, M. P., Van Haren, N. E M, Ophoff, R. A., Kahn, R. S., Bauer, M., Pfennig, A., Alda, M., Hajek, T., Mwangi, B., Soares, J. C., Nickson, T., Dimitrova, R., Sussmann, J. E., Hagenaars, S., Whalley, H. C., McIntosh, A. M., Thompson, P. M., and Andreassen, O. A.

Published
2016

43. Erratum:Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium

Author

Onderzoeksgroep 4, Brain, Hersenen-Bedrijfsvoering, Circulatory Health, Onderzoek, van Erp, T. G M, Hibar, D. P., Rasmussen, J. M., Glahn, D. C., Pearlson, G. D., Andreassen, O. A., Agartz, I., Westlye, L. T., Haukvik, U. K., Dale, A. M., Melle, I., Hartberg, C. B., Gruber, O., Kraemer, B., Zilles, D., Donohoe, G., Kelly, S., McDonald, C., Morris, D. W., Cannon, D. M., Corvin, A., Machielsen, M. W J, Koenders, L., de Haan, L., Veltman, D. J., Satterthwaite, T. D., Wolf, D. H., Gur, R. C., Gur, R. E., Potkin, S. G., Mathalon, D. H., Mueller, B. A., Preda, A., Macciardi, F., Ehrlich, S., Walton, E., Hass, J., Calhoun, V. D., Bockholt, H. J., Sponheim, S. R., Shoemaker, J. M., van Haren, N. E M, Hulshoff Pol, H.E., Ophoff, R. A., Kahn, R. S., Roiz-Santiañez, R., Crespo-Facorro, B., Wang, L., Alpert, K. I., Jönsson, E. G., Dimitrova, R., Bois, C., Whalley, H. C., McIntosh, A. M., Lawrie, S. M., Hashimoto, R., Thompson, P. M., Turner, J. A., Onderzoeksgroep 4, Brain, Hersenen-Bedrijfsvoering, Circulatory Health, Onderzoek, van Erp, T. G M, Hibar, D. P., Rasmussen, J. M., Glahn, D. C., Pearlson, G. D., Andreassen, O. A., Agartz, I., Westlye, L. T., Haukvik, U. K., Dale, A. M., Melle, I., Hartberg, C. B., Gruber, O., Kraemer, B., Zilles, D., Donohoe, G., Kelly, S., McDonald, C., Morris, D. W., Cannon, D. M., Corvin, A., Machielsen, M. W J, Koenders, L., de Haan, L., Veltman, D. J., Satterthwaite, T. D., Wolf, D. H., Gur, R. C., Gur, R. E., Potkin, S. G., Mathalon, D. H., Mueller, B. A., Preda, A., Macciardi, F., Ehrlich, S., Walton, E., Hass, J., Calhoun, V. D., Bockholt, H. J., Sponheim, S. R., Shoemaker, J. M., van Haren, N. E M, Hulshoff Pol, H.E., Ophoff, R. A., Kahn, R. S., Roiz-Santiañez, R., Crespo-Facorro, B., Wang, L., Alpert, K. I., Jönsson, E. G., Dimitrova, R., Bois, C., Whalley, H. C., McIntosh, A. M., Lawrie, S. M., Hashimoto, R., Thompson, P. M., and Turner, J. A.

Published
2016

44. Subcortical volumetric abnormalities in bipolar disorder

Author

Brain, Onderzoeksgroep 4, Onderzoeksgroep 2, Onderzoek, Circulatory Health, Hibar, D. P., Westlye, L. T., Van Erp, T. G M, Rasmussen, J., Leonardo, C. D., Faskowitz, J., Haukvik, U. K., Hartberg, C. B., Doan, N. T., Agartz, I., Dale, A. M., Gruber, O., Krämer, B., Trost, S., Liberg, B., Abé, C., Ekman, C. J., Ingvar, M., Landén, M., Fears, S. C., Freimer, N. B., Bearden, C. E., Sprooten, E., Glahn, D. C., Pearlson, G. D., Emsell, L., Kenney, J., Scanlon, C., McDonald, C., Cannon, D. M., Almeida, J., Versace, A., Caseras, X., Lawrence, N. S., Phillips, M. L., Dima, D., Delvecchio, G., Frangou, S., Satterthwaite, T. D., Wolf, D., Houenou, J., Henry, C., Malt, U. F., BØen, E., Elvs'shagen, T., Young, A. H., Lloyd, A. J., Goodwin, G. M., Mackay, C. E., Bourne, C., Bilderbeck, A., Abramovic, L., Boks, M. P., Van Haren, N. E M, Ophoff, R. A., Kahn, R. S., Bauer, M., Pfennig, A., Alda, M., Hajek, T., Mwangi, B., Soares, J. C., Nickson, T., Dimitrova, R., Sussmann, J. E., Hagenaars, S., Whalley, H. C., McIntosh, A. M., Thompson, P. M., Andreassen, O. A., Brain, Onderzoeksgroep 4, Onderzoeksgroep 2, Onderzoek, Circulatory Health, Hibar, D. P., Westlye, L. T., Van Erp, T. G M, Rasmussen, J., Leonardo, C. D., Faskowitz, J., Haukvik, U. K., Hartberg, C. B., Doan, N. T., Agartz, I., Dale, A. M., Gruber, O., Krämer, B., Trost, S., Liberg, B., Abé, C., Ekman, C. J., Ingvar, M., Landén, M., Fears, S. C., Freimer, N. B., Bearden, C. E., Sprooten, E., Glahn, D. C., Pearlson, G. D., Emsell, L., Kenney, J., Scanlon, C., McDonald, C., Cannon, D. M., Almeida, J., Versace, A., Caseras, X., Lawrence, N. S., Phillips, M. L., Dima, D., Delvecchio, G., Frangou, S., Satterthwaite, T. D., Wolf, D., Houenou, J., Henry, C., Malt, U. F., BØen, E., Elvs'shagen, T., Young, A. H., Lloyd, A. J., Goodwin, G. M., Mackay, C. E., Bourne, C., Bilderbeck, A., Abramovic, L., Boks, M. P., Van Haren, N. E M, Ophoff, R. A., Kahn, R. S., Bauer, M., Pfennig, A., Alda, M., Hajek, T., Mwangi, B., Soares, J. C., Nickson, T., Dimitrova, R., Sussmann, J. E., Hagenaars, S., Whalley, H. C., McIntosh, A. M., Thompson, P. M., and Andreassen, O. A.

Published
2016

45. Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium

Author

Onderzoeksgroep 4, Brain, Onderzoeksgroep 1, Hersenen-Bedrijfsvoering, Circulatory Health, Onderzoek, van Erp, T. G M, Hibar, D. P., Rasmussen, J. M., Glahn, D. C., Pearlson, G. D., Andreassen, O. A., Agartz, I., Westlye, L. T., Haukvik, U. K., Dale, A. M., Melle, I., Hartberg, C. B., Gruber, O., Kraemer, B., Zilles, D., Donohoe, G., Kelly, S., McDonald, C., Morris, D. W., Cannon, D. M., Corvin, A., Machielsen, M. W J, Koenders, L., de Haan, L., Veltman, D. J., Satterthwaite, T. D., Wolf, D. H., Gur, R. C., Gur, R. E., Potkin, S. G., Mathalon, D. H., Mueller, B. A., Preda, A., Macciardi, F., Ehrlich, S., Walton, E., Hass, J., Calhoun, V. D., Bockholt, H. J., Sponheim, S. R., Shoemaker, J. M., van Haren, N. E M, Pol, H. E H, Ophoff, R. A., Kahn, R. S., Roiz-Santiañez, R., Crespo-Facorro, B., Wang, L., Alpert, K. I., Jönsson, E. G., Dimitrova, R., Bois, C., Whalley, H. C., McIntosh, A. M., Lawrie, S. M., Hashimoto, R., Thompson, P. M., Turner, J. A., Onderzoeksgroep 4, Brain, Onderzoeksgroep 1, Hersenen-Bedrijfsvoering, Circulatory Health, Onderzoek, van Erp, T. G M, Hibar, D. P., Rasmussen, J. M., Glahn, D. C., Pearlson, G. D., Andreassen, O. A., Agartz, I., Westlye, L. T., Haukvik, U. K., Dale, A. M., Melle, I., Hartberg, C. B., Gruber, O., Kraemer, B., Zilles, D., Donohoe, G., Kelly, S., McDonald, C., Morris, D. W., Cannon, D. M., Corvin, A., Machielsen, M. W J, Koenders, L., de Haan, L., Veltman, D. J., Satterthwaite, T. D., Wolf, D. H., Gur, R. C., Gur, R. E., Potkin, S. G., Mathalon, D. H., Mueller, B. A., Preda, A., Macciardi, F., Ehrlich, S., Walton, E., Hass, J., Calhoun, V. D., Bockholt, H. J., Sponheim, S. R., Shoemaker, J. M., van Haren, N. E M, Pol, H. E H, Ophoff, R. A., Kahn, R. S., Roiz-Santiañez, R., Crespo-Facorro, B., Wang, L., Alpert, K. I., Jönsson, E. G., Dimitrova, R., Bois, C., Whalley, H. C., McIntosh, A. M., Lawrie, S. M., Hashimoto, R., Thompson, P. M., and Turner, J. A.

Published
2016

46. Genome-wide autozygosity is associated with lower general cognitive ability

Author

Howrigan, D P, primary, Simonson, M A, additional, Davies, G, additional, Harris, S E, additional, Tenesa, A, additional, Starr, J M, additional, Liewald, D C, additional, Deary, I J, additional, McRae, A, additional, Wright, M J, additional, Montgomery, G W, additional, Hansell, N, additional, Martin, N G, additional, Payton, A, additional, Horan, M, additional, Ollier, W E, additional, Abdellaoui, A, additional, Boomsma, D I, additional, DeRosse, P, additional, Knowles, E E M, additional, Glahn, D C, additional, Djurovic, S, additional, Melle, I, additional, Andreassen, O A, additional, Christoforou, A, additional, Steen, V M, additional, Hellard, S L, additional, Sundet, K, additional, Reinvang, I, additional, Espeseth, T, additional, Lundervold, A J, additional, Giegling, I, additional, Konte, B, additional, Hartmann, A M, additional, Rujescu, D, additional, Roussos, P, additional, Giakoumaki, S, additional, Burdick, K E, additional, Bitsios, P, additional, Donohoe, G, additional, Corley, R P, additional, Visscher, P M, additional, Pendleton, N, additional, Malhotra, A K, additional, Neale, B M, additional, Lencz, T, additional, and Keller, M C, additional

Published
2015
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49. Widespread white matter microstructural differences in schizophrenia across 4322 individuals: results from the ENIGMA Schizophrenia DTI Working Group

Author

Kelly, S, Jahanshad, N, Zalesky, A, Kochunov, P, Agartz, I, Alloza, C, Andreassen, O A, Arango, C, Banaj, N, Bouix, S, Bousman, C A, Brouwer, R M, Bruggemann, J, Bustillo, J, Cahn, W, Calhoun, V, Cannon, D, Carr, V, Catts, S, Chen, J, Chen, J-x, Chen, X, Chiapponi, C, Cho, Kl K, Ciullo, V, Corvin, A S, Crespo-Facorro, B, Cropley, V, De Rossi, P, Diaz-Caneja, C M, Dickie, E W, Ehrlich, S, Fan, F-m, Faskowitz, J, Fatouros-Bergman, H, Flyckt, L, Ford, J M, Fouche, J-P, Fukunaga, M, Gill, M, Glahn, D C, Gollub, R, Goudzwaard, E D, Guo, H, Gur, R E, Gur, R C, Gurholt, T P, Hashimoto, R, Hatton, S N, Henskens, F A, Hibar, D P, Hickie, I B, Hong, L E, Horacek, J, Howells, F M, Hulshoff Pol, H E, Hyde, C L, Isaev, D, Jablensky, A, Jansen, P R, Janssen, J, Jönsson, E G, Jung, L A, Kahn, R S, Kikinis, Z, Liu, K, Klauser, P, Knöchel, C, Kubicki, M, Lagopoulos, J, Langen, C, Lawrie, S, Lenroot, R K, Lim, K O, Lopez-Jaramillo, C, Lyall, A, Magnotta, V, Mandl, R C W, Mathalon, D H, McCarley, R W, McCarthy-Jones, S, McDonald, C, McEwen, S, McIntosh, A, Melicher, T, Mesholam-Gately, R I, Michie, P T, Mowry, B, Mueller, B A, Newell, D T, O'Donnell, P, Oertel-Knöchel, V, Oestreich, L, Paciga, S A, Pantelis, C, Pasternak, O, Pearlson, G, Pellicano, G R, Pereira, A, Pineda Zapata, J, Piras, F, Potkin, S G, Preda, A, Rasser, P E, Roalf, D R, Roiz, R, Roos, A, Rotenberg, D, Satterthwaite, T D, Savadjiev, P, Schall, U, Scott, R J, Seal, M L, Seidman, L J, Shannon Weickert, C, Whelan, C D, Shenton, M E, Kwon, J S, Spalletta, G, Spaniel, F, Sprooten, E, Stäblein, M, Stein, D J, Sundram, S, Tan, Y, Tan, S, Tang, S, Temmingh, H S, Westlye, L T, Tønnesen, S, Tordesillas-Gutierrez, D, Doan, N T, Vaidya, J, van Haren, N E M, Vargas, C D, Vecchio, D, Velakoulis, D, Voineskos, A, Voyvodic, J Q, Wang, Z, Wan, P, Wei, D, Weickert, T W, Whalley, H, White, T, Whitford, T J, Wojcik, J D, Xiang, H, Xie, Z, Yamamori, H, Yang, F, Yao, N, Zhang, G, Zhao, J, van Erp, T G M, Turner, J, Thompson, P M, and Donohoe, G

Abstract

The regional distribution of white matter (WM) abnormalities in schizophrenia remains poorly understood, and reported disease effects on the brain vary widely between studies. In an effort to identify commonalities across studies, we perform what we believe is the first ever large-scale coordinated study of WM microstructural differences in schizophrenia. Our analysis consisted of 2359 healthy controls and 1963 schizophrenia patients from 29 independent international studies; we harmonized the processing and statistical analyses of diffusion tensor imaging (DTI) data across sites and meta-analyzed effects across studies. Significant reductions in fractional anisotropy (FA) in schizophrenia patients were widespread, and detected in 20 of 25 regions of interest within a WM skeleton representing all major WM fasciculi. Effect sizes varied by region, peaking at (d=0.42) for the entire WM skeleton, driven more by peripheral areas as opposed to the core WM where regions of interest were defined. The anterior corona radiata (d=0.40) and corpus callosum (d=0.39), specifically its body (d=0.39) and genu (d=0.37), showed greatest effects. Significant decreases, to lesser degrees, were observed in almost all regions analyzed. Larger effect sizes were observed for FA than diffusivity measures; significantly higher mean and radial diffusivity was observed for schizophrenia patients compared with controls. No significant effects of age at onset of schizophrenia or medication dosage were detected. As the largest coordinated analysis of WM differences in a psychiatric disorder to date, the present study provides a robust profile of widespread WM abnormalities in schizophrenia patients worldwide. Interactive three-dimensional visualization of the results is available at www.enigma-viewer.org.

Published
2018
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50. Cortical abnormalities in bipolar disorder: an MRI analysis of 6503 individuals from the ENIGMA Bipolar Disorder Working Group

Author

Hibar, D P, Westlye, L T, Doan, N T, Jahanshad, N, Cheung, J W, Ching, C R K, Versace, A, Bilderbeck, A C, Uhlmann, A, Mwangi, B, Krämer, B, Overs, B, Hartberg, C B, Abé, C, Dima, D, Grotegerd, D, Sprooten, E, Bøen, E, Jimenez, E, Howells, F M, Delvecchio, G, Temmingh, H, Starke, J, Almeida, J R C, Goikolea, J M, Houenou, J, Beard, L M, Rauer, L, Abramovic, L, Bonnin, M, Ponteduro, M F, Keil, M, Rive, M M, Yao, N, Yalin, N, Najt, P, Rosa, P G, Redlich, R, Trost, S, Hagenaars, S, Fears, S C, Alonso-Lana, S, van Erp, T G M, Nickson, T, Chaim-Avancini, T M, Meier, T B, Elvsåshagen, T, Haukvik, U K, Lee, W H, Schene, A H, Lloyd, A J, Young, A H, Nugent, A, Dale, A M, Pfennig, A, McIntosh, A M, Lafer, B, Baune, B T, Ekman, C J, Zarate, C A, Bearden, C E, Henry, C, Simhandl, C, McDonald, C, Bourne, C, Stein, D J, Wolf, D H, Cannon, D M, Glahn, D C, Veltman, D J, Pomarol-Clotet, E, Vieta, E, Canales-Rodriguez, E J, Nery, F G, Duran, F L S, Busatto, G F, Roberts, G, Pearlson, G D, Goodwin, G M, Kugel, H, Whalley, H C, Ruhe, H G, Soares, J C, Fullerton, J M, Rybakowski, J K, Savitz, J, Chaim, K T, Fatjó-Vilas, M, Soeiro-de-Souza, M G, Boks, M P, Zanetti, M V, Otaduy, M C G, Schaufelberger, M S, Alda, M, Ingvar, M, Phillips, M L, Kempton, M J, Bauer, M, Landén, M, Lawrence, N S, van Haren, N E M, Horn, N R, Freimer, N B, Gruber, O, Schofield, P R, Mitchell, P B, Kahn, R S, Lenroot, R, Machado-Vieira, R, Ophoff, R A, Sarró, S, Frangou, S, Satterthwaite, T D, Hajek, T, Dannlowski, U, Malt, U F, Arolt, V, Gattaz, W F, Drevets, W C, Caseras, X, Agartz, I, Thompson, P M, and Andreassen, O A

Abstract

Despite decades of research, the pathophysiology of bipolar disorder (BD) is still not well understood. Structural brain differences have been associated with BD, but results from neuroimaging studies have been inconsistent. To address this, we performed the largest study to date of cortical gray matter thickness and surface area measures from brain magnetic resonance imaging scans of 6503 individuals including 1837 unrelated adults with BD and 2582 unrelated healthy controls for group differences while also examining the effects of commonly prescribed medications, age of illness onset, history of psychosis, mood state, age and sex differences on cortical regions. In BD, cortical gray matter was thinner in frontal, temporal and parietal regions of both brain hemispheres. BD had the strongest effects on left pars opercularis (Cohen’s d=-0.293; P=1.71 × 10-21), left fusiform gyrus (d=-0.288; P=8.25 × 10-21) and left rostral middle frontal cortex (d=-0.276; P=2.99 × 10-19). Longer duration of illness (after accounting for age at the time of scanning) was associated with reduced cortical thickness in frontal, medial parietal and occipital regions. We found that several commonly prescribed medications, including lithium, antiepileptic and antipsychotic treatment showed significant associations with cortical thickness and surface area, even after accounting for patients who received multiple medications. We found evidence of reduced cortical surface area associated with a history of psychosis but no associations with mood state at the time of scanning. Our analysis revealed previously undetected associations and provides an extensive analysis of potential confounding variables in neuroimaging studies of BD.

Published
2018
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