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Biomass from short rotation coppice (SRC) plantations has attracted widespread attention as a component of new sustainable energy concepts. Nevertheless, as yet the surface area of SRC plantations in Europe is relatively low compared to other biomass producing land-use systems. This is somewhat incomprehensible because it has been shown that SRC systems also offer distinct ecological benefits. Therefore, greater consideration of the related ecosystem services should be incorporated into land-use planning processes. Presented in this study is a conceptual framework for the integration of soil protection and nature conservation into the spatial prioritization of areas suitable for SRC. This approach includes the development of a site-specific yield model and the identification and classification of criteria and indicators for both soil protection and nature conservation. The basic concept for planning procedures was established and tested for the State of Saxony (Germany). Existing constraints were identified, and could be attributed mainly to the availability of adequate information at different spatial scales. The regional-scale study emphasized the considerable biomass potential of SRC and the related synergy effects for soil protection and nature conservation. Future work should focus on the local (district, farm) and catchment scale and attempt to integrate additional aspects such as hydrological ecosystem services and carbon sequestration.

Objectives Patients with multiple sclerosis ( MS) require lifelong therapy. However, success of disease-modifying therapies is dependent on patients' persistence and adherence to treatment schedules. In the setting of a large multicenter observational study, we aimed at assessing multiple parameters for their predictive power with respect to discontinuation of therapy. Materials and methods We analyzed 13 parameters to predict discontinuation of interferon beta-1b treatment during a 2-year follow-up period based on data from 395 patients with MS who were treatment-naïve at study onset. Besides clinical characteristics, patient-related psychosocial outcomes were assessed as well. Results Among patients without clinically relevant fatigue, males showed a higher persistence rate than females (80.3% vs 64.7%). Clinically relevant fatigue scores decreased the persistence rate in men and especially in women (71.4% and 51.2%). Besides gender and fatigue, univariable and multivariable analyses revealed further factors associated with interferon beta-1b therapy discontinuation, namely lower quality of life, depressiveness, and higher relapse rate before therapy initiation, while higher education, living without a partner, and higher age improved persistence. Conclusions Patients with higher grades of fatigue and depressiveness are at higher risk to prematurely discontinue MS treatment; especially, women suffering from fatigue have an increased discontinuation rate. [ABSTRACT FROM AUTHOR]