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204 results on '"Glasnov Toma N."'

1. Microwave-assisted continuous flow synthesis on industrial scale

Author

Morschhäuser Roman, Krull Matthias, Kayser Christoph, Boberski Cornelia, Bierbaum Ralf, Püschner Peter A., Glasnov Toma N., and Kappe C. Oliver

Subjects
continuous flow chemistry, high-temperature/high-pressure process windows, microwave chemistry, process intensification, Chemistry, QD1-999
Abstract

A continuous flow microwave system based on a transmission line short-circuited waveguide reactor concept is described. The continuous flow reactor is capable of operating in a genuine high-temperature/high-pressure process window (310°C/60 bar), applying a microwave transparent and chemical resistant cylindrical γ-Al2O3 tube as reaction zone. The system can be operated in an extremely energy efficient manner, utilizing 0.6–6 kW microwave power (2.45 GHz). The application of the reactor for processing four chemical transformations in a high-temperature/high-pressure regime with a throughout of 3.5–6.0 l/h is demonstrated.

Published
2012
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5. Adventures In Microwave-assisted Organic Synthesis: Contributions From The Kappe Laboratory 2000–2005

Author

Kappe, C. Oliver, Stadler, Alexander, Dallinger, Doris, Strohmeier, Gernot, Perez, Rolando, Zbruyev, Oleksandr I., Stiasni, Nikolai, Walla, Peter, Gorobets, Nikolay, Yousefi, Behrooz, Mont, Nuria, Desai, Bimbisar, Lengar, Alenka, Krascsenicsová, Katarina, Garbacia, Stefania, Khanetskyy, Bogdan, Glasnov, Toma N., Kremsner, Jennifer M., da Silva, Ana Gomez, Mordini, Alessandro, editor, and Faigl, Ferenc, editor

Published
2008
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17. Journal of Photochemistry and Photobiology B: Biology / Photoswitching of model ion channels in lipid bilayers

Author

Pfeffermann, Jürgen, Eicher, Barbara, Boytsov, Danila, Hannesschläger, Christof, Galimzyanov, Timur R., Glasnov, Toma N., Pabst, Georg, Akimov, Sergeiy A., and Pohl, Peter

Subjects
Regulation of mechanosensitive channels, Photolipid, Photoinduced changes of membrane elasticity, Light activation of membrane channels
Abstract

Membrane proteins can be regulated by alterations in material properties intrinsic to the hosting lipid bilayer. Here, we investigated whether the reversible photoisomerization of bilayer-embedded diacylglycerols (Opto-DArG) with two azobenzene-containing acyl chains may trigger such regulatory events. We observed an augmented open probability of the mechanosensitive model channel gramicidin A (gA) upon photoisomerizing OptoDArG's acyl chains from trans to cis: integral planar bilayer conductance brought forth by hundreds of simultaneously conducting gA dimers increased by typically >50% – in good agreement with the observed in-crease in single-channel lifetime. Further, (i) increments in the electrical capacitance of planar lipid bilayers and protrusion length of aspirated giant unilamellar vesicles into suction pipettes, as well as (ii) changes of small- angle X-ray scattering of multilamellar vesicles indicated that spontaneous curvature, hydrophobic thickness, and bending elasticity decreased upon switching from trans- to cis-OptoDArG. Our bilayer elasticity model for gA supports the causal relationship between changes in gA activity and bilayer material properties upon photo-isomerization. Thus, we conclude that photolipids are deployable for converting bilayers of potentially diverse origins into light-gated actuators for mechanosensitive protein Fonds zur Förderung der Wissenschaftlichen Forschung TAI 181 Version of record

Published
2021
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25. Photoswitchable Diacylglycerols Identify a Novel Lipid-Gating Mechanism in TRPC3 Channels

Author

Tiapko, Oleksandra, primary, Lichtenegger, Michaela, additional, de la Cruz, Gema Guedes, additional, Glasnov, Toma N., additional, Svobodova, Barbora, additional, Schreibmayer, Wolfgang, additional, Platzer, Dieter, additional, Krenn, Sarah, additional, Shrestha, Niroj, additional, Schindl, Rainer, additional, Stockner, Thomas, additional, Romanin, Christoph, additional, and Groschner, Klaus, additional

Published
2018
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26. Tuning of chemo- and regioselectivities in multicomponent condensations of 5-aminopyrazoles, dimedone, and aldehydes

Author

Chebanov, Valentin A., Saraev, Vyacheslav E., Desenko, Sergey M., Chernenko, Vitaliy N., Knyazeva, Irina V., Groth, Ulrich, and Glasnov, Toma N.

Subjects
Aldehydes -- Chemical properties, Condensation -- Analysis, Ketones -- Chemical properties, Pyrazoles -- Chemical properties, Quinoline -- Chemical properties, Biological sciences, Chemistry
Abstract

The three-component condensation of 5-aminopyrazoles, aromatic aldehydes, and cyclic 1,3-diketones to selectively obtain three distinct reaction products, pyrazolo[3,4-b]quinolin-5-ones, pyrazolo[5,1-b]quinazolin-8-ones, and pyrazolo[4,3-c]quinolizin-9-ones is presented. The tricyclic heterocycles could give moderate to good isolated yields.

Published
2008

27. Symmetrical bisquinolones via metal-catalyzed cross-coupling and homocoupling reactions

Author

Hashim, Jamshed, Glasnov, Toma N., Kremsner, Jennifer M., and Kappe, C. Oliver

Subjects
Quinolones -- Chemical properties, Quinolones -- Electric properties, Palladium catalysts -- Chemical properties, Spin coupling -- Research, Biological sciences, Chemistry
Abstract

Functionalized 4,4'-bisquinolones are synthesized by microwave-assisted palladium(0)-catalyzed one-port borylation/Suzuki cross-coupling reactions or via nickel(0)-mediated homocouplings of 4-chloroquinolin-2(1H)-one precursors. The procedures are very important for the preparation of novel types of symmetrical bisquinolones.

Published
2006

28. Microwave-assisted multistep synthesis of functionalized 4-arylquinolin-2(1H)-ones using palladium-catalyzed cross-coupling chemistry

Author

Glasnov, Toma N., Stadlbauer, Wolfgang, and Kappe, C. Oliver

Subjects
Chemical reactions -- Research, Quinoline -- Chemical properties, Palladium -- Chemical properties, Biological sciences, Chemistry
Abstract

Biologically active 4-aryl-3-alkenyl-substituted quinolin-2(1H)-ones is synthesized in a short and concise manner employing readily available 4-hydroxyquinolin-2(1H)-ones as intermediates. Some of the key steps in the synthesis include the derivatization of the quinolin-2(1H)-one cores using palladium-catalyzed Suzuki and Heck reactions, installing the 4-aryl and 3-alkenyl substituents.

Published
2005

30. Store-Operated Ca2+Entry Does Not Control Proliferation in Primary Cultures of Human Metastatic Renal Cellular Carcinoma

Author

Dragoni, Silvia, primary, Turin, Ilaria, additional, Laforenza, Umberto, additional, Potenza, Duilio Michele, additional, Bottino, Cinzia, additional, Glasnov, Toma N., additional, Prestia, Martina, additional, Ferulli, Federica, additional, Saitta, Anna, additional, Mosca, Alessandra, additional, Guerra, Germano, additional, Rosti, Vittorio, additional, Luinetti, Ombretta, additional, Ganini, Carlo, additional, Porta, Camillo, additional, Pedrazzoli, Paolo, additional, Tanzi, Franco, additional, Montagna, Daniela, additional, and Moccia, Francesco, additional

Published
2014
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46. Cover Picture: Green and Sustainable Chemical Synthesis Using Flow Microreactors / Continuous Synthesis of tert-Butyl Peroxypivalate using a Single-Channel Microreactor Equipped with Orifices as Emulsification Units / Heterogeneous Catalytic Hydrogenation

Author

Yoshida, Jun-ichi, primary, Kim, Heejin, additional, Nagaki, Aiichiro, additional, Illg, Tobias, additional, Hessel, Volker, additional, Löb, Patrick, additional, Schouten, Jaap C., additional, Irfan, Muhammad, additional, Glasnov, Toma N., additional, and Kappe, C. Oliver, additional

Published
2011
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