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1,559 results on '"Glass, D"'

1. ALMA observations of massive molecular gas reservoirs in dusty early-type galaxies

Author

Sansom, A. E., Glass, D. H. W., Bendo, G. J., Davis, T. A., Rowlands, K., Bourne, N., Dunne, L., Eales, S., Kaviraj, S., Popescu, C., Smith, M., and Viaene, S.

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

Unresolved gas and dust observations show a surprising diversity in the amount of interstellar matter in early-type galaxies. Using ALMA observations we resolve the ISM in z$\sim$0.05 early-type galaxies. From a large sample of early-type galaxies detected in the Herschel Astrophysical Terahertz Large Area Survey (H-ATLAS) we selected five of the dustiest cases, with dust masses M$_d\sim$several$\times10^7$M$_\odot$, with the aim of mapping their submillimetre continuum and $^{12}$CO(2-1) line emission distributions. These observations reveal molecular gas disks. There is a lack of associated, extended continuum emission in these ALMA observations, most likely because it is resolved out or surface brightness limited, if the dust distribution is as extended as the CO gas. However, two galaxies have central continuum ALMA detections. An additional, slightly offset, continuum source is revealed in one case, which may have contributed to confusion in the Herschel fluxes. Serendipitous continuum detections further away in the ALMA field are found in another case. Large and massive rotating molecular gas disks are mapped in three of our targets, reaching a few$\times10^{9}$M$_\odot$. One of these shows evidence of kinematic deviations from a pure rotating disc. The fields of our two remaining targets contain only smaller, weak CO sources, slightly offset from the optical galaxy centres. These may be companion galaxies seen in ALMA observations, or background objects. These heterogeneous findings in a small sample of dusty early-type galaxies reveal the need for more such high spatial resolution studies, to understand statistically how dust and gas are related in early-type galaxies., Comment: 15 pages, 10 figures, 3 tables, accepted for publication in MNRAS

Published
2018
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2. Alternative Pathway Complement Activation and Low Circulating Inhibitors Associate With Severity and Mortality in COVID-19 and Non-COVID Sepsis

Author

Meyer, N.J., primary, Devalaraja-Narashimha, K., additional, Laudanski, K., additional, Ehmann, P., additional, Afolayan, S., additional, DerOhannessian, S., additional, Spade, G., additional, Ittner, C.A.G., additional, Turner, A.P., additional, Esperanza, M., additional, Dunn, T.G., additional, Ko, J.-A.A., additional, Weaver, J., additional, PennMedicine Biobank, P., additional, Zhu, O., additional, Scott, D., additional, Hamon, S., additional, Wistermayer, A., additional, Hersch, L., additional, Hooper, A., additional, Burczynski, M., additional, Glass, D., additional, Hamilton, J., additional, Jones, T.K., additional, Giannini, H.M., additional, Shashaty, M.G.S., additional, Reilly, J.P., additional, Morton, L., additional, FitzGerald, G.A., additional, and Rader, D.J., additional

Published
2024
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3. Problems from the workshop on 'Automorphisms of Curves' (Leiden, August, 2004)

Author

Bouw, I., Chinburg, T., Cornelissen, G., Gasbarri, C., Glass, D., Lehr, C., Matignon, M., Oort, F., Pries, R., and Wewers, S.

Subjects
Mathematics - Algebraic Geometry, Mathematics - Number Theory, 14H37
Abstract

Contents: Rational functions with given monodromy on generic curves (I. Bouw & S. Wewers); Can deformation rings of group representations not be local complete intersections? (T. Chinburg); Lifting an automorphism group to finite characteristic (G. Cornelissen); Flat connections and representations of the fundamental group in characteristic p>0 (C. Gasbarri) Questions on p-torsion of hyperelliptic curves (D. Glass & R. Pries); Automorphisms of curves and stable reduction (C. Lehr & M. Matignon); p-groups as automorphism groups of curves in characteristic p; Lifting Galois covers of smooth curves (M. Matignon); Abelian varieties isogenous to a Jacobian (F. Oort); Minimal maximal number of automorphisms of curves (F. Oort), Comment: 47 pages; edited by G. Cornelissen and F. Oort

Published
2004

6. Variability in the therapeutic management of advanced ovarian cancer patients: a five-country survey of oncologists

Author

Audibert C, Perlaky A, Stuntz M, and Glass D

Subjects
Advanced ovarian cancer, BRCA mutation, maintenance, treatment, targeted therapies, Therapeutics. Pharmacology, RM1-950
Abstract

Céline Audibert,1 Anna Perlaky,2 Mark Stuntz,2 Daniel Glass2 1Deerfield Institute, Epalinges, Switzerland; 2Deerfield Institute, New York, NY, USA Background: Advanced ovarian cancer patients have a poor prognosis, mainly because the disease is diagnosed at a late stage. A number of therapeutic approaches, such as neoadjuvant and maintenance therapies, have been developed to try to improve treatment outcome. In parallel, the targeted therapies bevacizumab and olaparib have recently been approved for ovarian cancer treatment. The goal of our survey was to provide a comprehensive, global depiction of advanced ovarian cancer treatments across different regions.Patients and methods: Oncologists from France, Italy, Germany, the UK, and the USA were invited to participate in an online survey. Participants were eligible if they personally managed at least 15 ovarian cancer patients. Quantitative questions addressed the proportion of patients in neoadjuvant, treatment, and maintenance settings; proportion of BRCA-positive patients; and the type of treatment prescribed per setting and per line of therapy, depending on the patient’s BRCA status.Results: A total of 138 respondents completed our survey in Europe and 132 in the USA. The proportions of patients in treatment, maintenance, and remission were identical across each country and line of treatment at 60%, 20%, and 20%, respectively. The proportion of BRCA-tested patients ranged from 45% in Italy to 73% in the USA, with 10% (UK)–21% (Italy) of tested patients having a positive status. Levels of bevacizumab and olaparib prescriptions differed based on the country, line of treatment, and setting, with a significant share of patients receiving both drugs outside of their approved indications for ovarian cancer treatment.Conclusion: This survey provides real-world data on how advanced ovarian cancer patients are currently treated: 1) BRCA testing was not performed systematically, which raises concerns regarding access to treatment and 2) absence of consensus regarding which chemotherapeutic regimens or targeted therapy to use in different stages of the disease. Keywords: advanced ovarian cancer, BRCA mutation, maintenance, treatment, targeted therapies

Published
2017

11. Communication practices and awareness of resources for acromegaly patients among endocrinologists

Author

Polanco-Briceno S, Glass D, and Plunkett C

Subjects
acromegaly, patient education, patient adherence, survey, Medicine (General), R5-920
Abstract

Susan Polanco-Briceno,1 Daniel Glass,1 Cindy Plunkett2 1Deerfield Institute, New York, NY, USA; 2Department of Internal Medicine, Metabolism Endocrinology & Diabetes (MEND), University of Michigan, Ann Arbor, MI, USA Purpose: This study was designed to assess the awareness and utilization of resources to improve patients’ treatment experiences among endocrinologists who currently treat patients with acromegaly. Methods: A total of 4,280 US endocrinologists were randomly selected from the CMS National Plan and Provider Enumeration System and were invited by mail to participate in a 20-minute online survey. In order to qualify, respondents had to be the primary physician making treatment decisions for at least one patient for their acromegaly. Results: Results are based on responses from 126 physicians from primarily urban and suburban practices, with a median of five acromegaly patients. A total of 70% of patients are currently receiving drug therapy; among these, 91% are on octreotide (51%), lanreotide (29%), or pasireotide (11%), alone or in combination with another therapy. Nearly half of the respondents thought that the impact of patient adherence on therapy outcome for acromegaly was either not very (40%) or not at all (7%) significant. Respondents who believe patient adherence significantly impacts treatment outcome were significantly more likely to discuss automated adherence reminders (50% vs 26%; P=0.015), mobile administration programs (57% vs 35%; P=0.029), and symptom tracking (72% vs 42%; P=0.002). Overall, 44% of respondents routinely recommend education/emotional support programs, and 25% routinely recommend financial assistance programs. Respondents who believe patient adherence significantly impacts treatment outcome generally were more familiar with individual education and emotional support programs compared to those who do not, although they were not more likely to routinely refer patients to any of these resources. Conclusion: There are unmet needs with respect to increasing awareness among physicians of the importance of patient adherence to therapy, resources available to patients, and how collaboration among patients, nurses, and physicians can improve adherence and overall treatment experiences. Keywords: financial support programs, emotional support programs, referrals

Published
2016

16. Effects of proton pump inhibitors and electrolyte disturbances on arrhythmias

Author

El-Charabaty E, Saifan C, Abdallah M, Naboush A, Glass D, Azzi G, Azzi Y, Khan A, Baydoun H, Rondla C, Parekh N, and El-Sayegh S

Subjects
Medicine (General), R5-920
Abstract

Elie El-Charabaty, Chadi Saifan, Mokhtar Abdallah, Ali Naboush, Daniel Glass, Georges Azzi, Yorg Azzi, Ahsan Khan, Hassan Baydoun, Chetana Rondla, Ninad Parekh, Suzanne El-SayeghDepartment of Medicine, Staten Island University Hospital, Staten Island, NY, USAAbstract: Several case reports have been written regarding the relationship between the use of proton pump inhibitors (PPI) and hypomagnesemia. Some of these reported cases have electrocardiogram abnormalities where electrolytes deficiencies were the contributing factor for these events. This study investigates the correlation between different arrhythmias and the use of PPI and hypomagnesaemia incidence. Four-hundred and twenty-one patients admitted to the critical care unit with unstable angina, non-ST elevation myocardial infarction, and ST-elevation myocardial infarction were included in this study. One-hundred and eighty-four patients (43.8%) received PPI and 237 patients (51.16%) did not, magnesium levels were low (

Published
2013

17. Computational Simulations of the NASA Langley HyMETS Arc-Jet Facility

Author

Brune, A. J, Bruce, W. E., III, Glass, D. E, and Splinter, S. C

Subjects
Research And Support Facilities (Air), Fluid Mechanics And Thermodynamics
Abstract

The Hypersonic Materials Environmental Test System (HyMETS) arc-jet facility located at the NASA Langley Research Center in Hampton, Virginia, is primarily used for the research, development, and evaluation of high-temperature thermal protection systems for hypersonic vehicles and reentry systems. In order to improve testing capabilities and knowledge of the test article environment, an effort is underway to computationally simulate the flow-field using computational fluid dynamics (CFD). A detailed three-dimensional model of the arc-jet nozzle and free-jet portion of the flow-field has been developed and compared to calibration probe Pitot pressure and stagnation-point heat flux for three test conditions at low, medium, and high enthalpy. The CFD model takes into account uniform pressure and non-uniform enthalpy profiles at the nozzle inlet as well as catalytic recombination efficiency effects at the probe surface. Comparing the CFD results and test data indicates an effectively fully-catalytic copper surface on the heat flux probe of about 10% efficiency and a 2-3 kpa pressure drop from the arc heater bore, where the pressure is measured, to the plenum section, prior to the nozzle. With these assumptions, the CFD results are well within the uncertainty of the stagnation pressure and heat flux measurements. The conditions at the nozzle exit were also compared with radial and axial velocimetry. This simulation capability will be used to evaluate various three-dimensional models that are tested in the HyMETS facility. An end-to-end aerothermal and thermal simulation of HyMETS test articles will follow this work to provide a better understanding of the test environment, test results, and to aid in test planning. Additional flow-field diagnostic measurements will also be considered to improve the modeling capability.

Published
2017

24. Meeting Report: Aging Research and Drug Discovery

Author

Meron, E, Thaysen, M, Angeli, S, Antebi, A, Barzilai, N, Baur, JA, Bekker-Jensen, S, Birkisdottir, M, Bischof, E, Bruening, J, Brunet, A, Buchwalter, A, Cabreiro, F, Cai, S, Chen, BH, Ermolaeva, M, Ewald, CY, Ferrucci, L, Florian, MC, Fortney, K, Freund, A, Georgievskaya, A, Gladyshev, VN, Glass, D, Golato, T, Gorbunova, V, Hoejimakers, J, Houtkooper, RH, Jager, S, Jaksch, F, Janssens, G, Jensen, MB, Kaeberlein, M, Karsenty, G, de Keizer, P, Kennedy, B, Kirkland, JL, Kjaer, M, Kroemer, G, Lee, K-F, Lemaitre, J-M, Liaskos, D, Longo, VD, Lu, Y-X, MacArthur, MR, Maier, AB, Manakanatas, C, Mitchell, SJ, Moskalev, A, Niedernhofer, L, Ozerov, I, Partridge, L, Passegue, E, Petr, MA, Peyer, J, Radenkovic, D, Rando, TA, Rattan, S, Riedel, CG, Rudolph, L, Ai, R, Serrano, M, Schumacher, B, Sinclair, DA, Smith, R, Suh, Y, Taub, P, Trapp, A, Trendelenburg, A-U, Valenzano, DR, Verburgh, K, Verdin, E, Vijg, J, Westendorp, RGJ, Zonari, A, Bakula, D, Zhavoronkov, A, Scheibye-Knudsen, M, Meron, E, Thaysen, M, Angeli, S, Antebi, A, Barzilai, N, Baur, JA, Bekker-Jensen, S, Birkisdottir, M, Bischof, E, Bruening, J, Brunet, A, Buchwalter, A, Cabreiro, F, Cai, S, Chen, BH, Ermolaeva, M, Ewald, CY, Ferrucci, L, Florian, MC, Fortney, K, Freund, A, Georgievskaya, A, Gladyshev, VN, Glass, D, Golato, T, Gorbunova, V, Hoejimakers, J, Houtkooper, RH, Jager, S, Jaksch, F, Janssens, G, Jensen, MB, Kaeberlein, M, Karsenty, G, de Keizer, P, Kennedy, B, Kirkland, JL, Kjaer, M, Kroemer, G, Lee, K-F, Lemaitre, J-M, Liaskos, D, Longo, VD, Lu, Y-X, MacArthur, MR, Maier, AB, Manakanatas, C, Mitchell, SJ, Moskalev, A, Niedernhofer, L, Ozerov, I, Partridge, L, Passegue, E, Petr, MA, Peyer, J, Radenkovic, D, Rando, TA, Rattan, S, Riedel, CG, Rudolph, L, Ai, R, Serrano, M, Schumacher, B, Sinclair, DA, Smith, R, Suh, Y, Taub, P, Trapp, A, Trendelenburg, A-U, Valenzano, DR, Verburgh, K, Verdin, E, Vijg, J, Westendorp, RGJ, Zonari, A, Bakula, D, Zhavoronkov, A, and Scheibye-Knudsen, M

Abstract

Aging is the single largest risk factor for most chronic diseases, and thus possesses large socioeconomic interest to continuously aging societies. Consequently, the field of aging research is expanding alongside a growing focus from the industry and investors in aging research. This year's 8th Annual Aging Research and Drug Discovery (ARDD) meeting was organized as a hybrid meeting from August 30th to September 3rd 2021 with more than 130 attendees participating on-site at the Ceremonial Hall at University of Copenhagen, Denmark, and 1800 engaging online. The conference comprised of presentations from 75 speakers focusing on new research in topics including mechanisms of aging and how these can be modulated as well as the use of AI and new standards of practices within aging research. This year, a longevity workshop was included to build stronger connections with the clinical community.

Published
2022

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