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231 results on '"Gleispach H"'

28. Prenatal detection of Canavan disease

Author

Ozand, P.T., primary, Feryal, R.R., additional, Gascon, G.G., additional, Gleispach, H., additional, Al Aqeel, A., additional, Cook, J.D., additional, Nester, M.J., additional, Al Odaib, A., additional, and Leis, HansJ., additional

Published
1991
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31. Tumor host relations.

Author

Schaur, R., Fellier, H., Gleispach, H., Fink, E., and Kronberger, L.

Abstract

Plasma cortisol was measured by a protein binding technique in 81 patients with malignant tumors of different extent and various sites and in 82 patients with benign surgical diseases. The mean value of the tumor patients ( $$\bar x \pm s = 165 \pm 69 \mu g$$ cortisol/l plasma) was increased significantly compared with the benign surgical disorders (100±45 μg/l). Within the group of patients with benign surgical disorders there was little variation by the type of disease (cortisol mean values given in brackets): benign breast tumors (95), gall stones (107), ulcer of the stomach and duodenum (96), hernia (78), appendicitis acuta (112), and struma (90). The results are in accordance with the hypothesis that glucocorticoids are involved in the increased protein catabolism of skeletal muscles and other signs of cachectic tumor patients. [ABSTRACT FROM AUTHOR]

Published
1979
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39. Ein Beitrag zur Verwendung von Bistrimethylsilylacetamid bei der gas-chromatographischen Steroidbestimmung.

Author

Gleispach, H.

Abstract

Copyright of Fresenius' Zeitschrift für Analytische Chemie is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
1969
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44. [5 years neuroblastoma screening in Austria: rate of participation, results and a comparison with other screening areas]

Author

Kerbl R, Ce, Urban, Ladenstein R, Schnellauf C, Sitzwohl C, Lackner H, Gleispach H, Fauler G, Peter F. Ambros, Im, Ambros, Rumpler S, Gadner H, Spuller E, Höfler G, Amann G, Kytir J, and Mutz I

Subjects
Male, Incidence, Infant, Homovanillic Acid, Patient Acceptance of Health Care, Prognosis, Neuroblastoma, Vanilmandelic Acid, Cross-Sectional Studies, Austria, Humans, Mass Screening, Female, Reagent Strips
Abstract

In late 1990 a screening program for the early detection of neuroblastoma in infants was introduced in Austria. The program is performed on a voluntary basis in collaboration with general pediatricians and practitioners. Filter strips for urine collection are distributed to parents of infants aged seven to nine months on the occasion of a routine check up. The samples are sent to the laboratory by parents and analysed for vanillylmandelic acid (VMA) and homovanillic acid (HVA). Between January 1991 and December 1995 125,201 infants were screened. The compliance rate was 26.8% for Austria, but great differences were seen for different regions (65% in Carinthia, 10% in Vorarlberg). 30 children were admitted to hospital for investigation of repeatedly elevated urine catecholamines. A neuroblastoma was identified in 16 cases. In 12 of these cases at least one unfavorable prognostic factor was present (stageor = 3, elevated LDH, unfavorable histology, N-myc amplification, di- or tetraploidy). Neuroblastoma screening of infants aged more than six months seems to detect predominantly those tumors which are unlikely to regress spontaneously. The observation of one false negative case, however, demonstrates that neuroblastomas which become clinically manifest at a later date may remain undetected by early screening. Possible advantages of shifting screening to a later age and repeated screening are discussed.

45. Effect of auranofin on resorption, prostaglandin synthesis and ultrastructure of bone cells in cultured mouse calvaria

Author

Klaushofer K, Hoffmann O, Hörandner H, Karasegh S, Nadja Fratzl-Zelman, Hj, Leis, Gleispach H, Koller K, and Peterlik M

Subjects
Mice, Auranofin, Skull, Prostaglandins, Animals, Bone Resorption, Bone and Bones, Cells, Cultured
Abstract

Auranofin (AF) in concentrations between 3 x 10(-7) and 3 x 10(-6) mol/l stimulated bone resorption in cultured neonatal mouse calvariae significantly with 1 x 10(-6) mol/l being most potent. Complete inhibition by 5 x 10(-7) mol/l indomethacin and increased medium concentrations of prostaglandin (PG) E2 and 6-keto-PGF1 alpha after 72 h indicate a PG mediated mechanism. Morphology revealed active osteoclasts. Cytotoxic effects were observed with 3 x 10(-6) and 1 x 10(-5) mol/l AF with osteocytes and osteoblasts being considerably more sensitive than osteoclasts. The latter concentrations inhibited bone resorption stimulated by parathyroid hormone (PTH) 1,25-dihydroxyvitamin D3, PGE2, thrombin and interleukin 1. The stimulatory effect of AF on PG production and subsequent bone resorption could limit its therapeutic usefulness.

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