1. Hepatitis B virus and hepatitis D virus infection in women with or at risk for HIV infection in the United States
- Author
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Argirion, Ilona, Mahale, Parag, Pfeiffer, Ruth M, Liu, Ping, Adimora, Adaora A, Akiyama, Matthew J, Bolivar, Hector H, French, Audrey, Plankey, Michael, Price, Jennifer C, Rana, Aadia, Sheth, Anandi, Koshiol, Jill, Seaberg, Eric C, Kuniholm, Mark H, Glenn, Jeffrey, and O’Brien, Thomas R
- Subjects
Medical Microbiology ,Biomedical and Clinical Sciences ,Clinical Sciences ,Immunology ,Hepatitis - B ,HIV/AIDS ,Digestive Diseases ,Chronic Liver Disease and Cirrhosis ,Liver Disease ,Infectious Diseases ,Clinical Research ,Hepatitis ,Aetiology ,2.2 Factors relating to the physical environment ,Infection ,Good Health and Well Being ,epidemiology ,hepatitis B virus ,hepatitis D virus ,hepatitis C virus ,anti-HDV ,persons who injected drugs ,Biomedical and clinical sciences ,Health sciences - Abstract
Hepatitis D virus (HDV) requires co-infection with hepatitis B virus (HBV). Human immunodeficiency virus (HIV) shares transmission routes with these viruses. Among 4,932 US women infected with or at-risk for HIV during 1994-2015, HBV surface antigen (HBsAg) positivity was more common in women with HIV (2.8% vs. 1.2%; p = 0.001); HDV was more common among participants enrolled during 2013-2015 (p = 0.0004) and those with resolved rather than active hepatitis C (1.9% vs. 0.5%; p = 0.02). Among HBsAg-positive women (n = 117), HDV antibody prevalence was 22% and did not vary by HIV status; HDV infection was associated with the presence of advanced fibrosis/cirrhosis at enrollment (adjusted odds ratio, 5.70; 95% confidence interval, 1.46-22.29). Our results demonstrate the importance of HDV testing in HBV-infected US women.
- Published
- 2023