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425 results on '"Glick, S. D."'

1. Differential interactions of desipramine with amphetamine and methamphetamine: Evidence that amphetamine releases dopamine from noradrenergic neurons in the medial prefrontal cortex

Author

Shoblock, James R, Maisonneuve, I M, and Glick, S D

Subjects
amphetamine, dopamine, medial prefrontal cortex, microdialysis, methamphetamine, norepinephrine
Abstract

Amphetamine is more effective than methamphetamine at raising dopamine levels in the prefrontal cortex. The current study tested the hypothesis that norepinephrine transporters are involved in this difference. Using microdialysis, dopamine, norepinephrine, and serotonin were measured in the rat prefrontal cortex after administration of methamphetamine or amphetamine, with and without perfusion of desipramine. Amphetamine raised norepinephrine levels more than methamphetamine did. Desipramine raised dopamine and serotonin levels but did not alter metabolite levels. Desipramine attenuated the increase in dopamine by amphetamine while increasing the dopamine released by methamphetamine. These data suggest that methamphetamine and amphetamine differ in altering prefrontal cortical dopamine levels and in interacting with norepinephrine transporters. It is proposed that amphetamine releases dopamine in the prefrontal cortex primarily through norepinephrine transporters, whereas methamphetamine interacts minimally with norepinephrine transporters.

Published
2004

21. Pharmacological comparison of the effect of ibogaine and 18-methoxycoronaridine on isolated smooth muscle from the rat and guinea-pig

Author

Mundey, M K, Blaylock, N A, Mason, R, Glick, S D, Maisonneuve, I M, and Wilson, V G

Subjects
Male, Dose-Response Relationship, Drug, Portal Vein, Guinea Pigs, Urinary Bladder, Muscle, Smooth, Rats, Vas Deferens, Ileum, Ibogaine, Papers, Animals, Excitatory Amino Acid Antagonists, Muscle Contraction
Abstract

Ibogaine and 18-methoxycoronaridine are naturally occurring alkaloids reported to possess antiaddictive properties in several models of drug dependence. We have examined their effect at mu-opioid receptors regulating neurogenic contractions of several smooth muscle preparations and also against spontaneous contractions of the rat isolated portal vein. Ibogaine (pIC(50) 5.28) and 18-methoxycoronaridine (pIC(50) 5.05) caused a concentration-dependent inhibition of cholinergic contractions of the guinea-pig ileum which was not affected by the opioid receptor antagonist naloxone (1 microM). In the rat isolated vas deferens ibogaine and 18-methoxycoronaridine caused a concentration-dependent enhancement of purinergic contractions. Both agents (30 microM) caused a 3 - 5 fold rightward displacement of DAMGO-induced inhibition of purinergic contractions, but similar effects were observed for ibogaine against alpha(2)-adrenoceptor-mediated inhibition of neurogenic responses. In the guinea-pig isolated bladder both ibogaine (10 microM) and 18-methoxycoronaridine (10 microM) caused a 2 fold increase in the purinergic component of neurogenic contractions without significantly altering cholinergic contractions or responses to exogenous ATP. In contrast, ibogaine (1 - 30 microM), but not 18-methoxycoronaridine, caused a concentration-dependent enhancement of spontaneous contractions of the rat isolated portal vein. In summary, while ibogaine and 18-methoxycoronaridine modulated electrically-evoked contractions in the three preparations examined, we have no evidence for a selective interaction with pre-junctional mu-opioid receptors. The pronounced enhancement of purinergic contractions produced by both agents is a novel finding and worthy of further investigation.

Published
2000

40. Synthesis and Biological Evaluation of 18-Methoxycoronaridine Congeners. Potential Antiaddiction Agents

Author

Kuehne, M. E., He, L., Jokiel, P. A., Pace, C. J., Fleck, M. W., Maisonneuve, I. M., Glick, S. D., and Bidlack, J. M.

Abstract

Variation of the methoxycarbonyl and C-18 substituents of the antiaddictive compound 18-methoxycoronaridine, and contraction of its isoquinuclidine ring segment, provided 15 congeners for SAR evaluation at opioid and α3β4 nicotinic acetylcholine receptors. The opioid activities were relatively low, and the α3β4 nicotinic acetylcholine receptor activities were found to correlate with in vivo antiaddictive activities.

Published
2003

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