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2 results on '"Glioma stem cells niche"'

1. Oligodendrocyte Progenitor Cells and Macrophages/Microglia Produce Glioma Stem Cell Niches at the Tumor Border

Author

Hideo Nakamura, Takuichiro Hide, Jun Ichi Kuratsu, Akitake Mukasa, Yuko Miyasato, Motohiro Takeya, Yoshihiro Komohara, Shigetoshi Yano, and Keishi Makino

Subjects
0301 basic medicine, Chemoradioresistance, Macrophage, lcsh:Medicine, Biology, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Recurrence, Glioma, Border niche, microRNA, medicine, Tumor Microenvironment, Humans, Stemness, Oligodendrocyte progenitor cell, Oligodendrocyte Precursor Cells, lcsh:R5-920, Microglia, Brain Neoplasms, Macrophages, lcsh:R, Oligodendrocyte differentiation, General Medicine, FGF1, medicine.disease, Oligodendrocyte, nervous system diseases, 030104 developmental biology, medicine.anatomical_structure, Cancer research, Neoplastic Stem Cells, Stem cell, Neoplasm Recurrence, Local, lcsh:Medicine (General), Glioblastoma, Glioma stem cells niche, Research Paper
Abstract

Glioblastoma (GBM) usually develops in adult brain white matter. Even after complete resection, GBM recurs around the tumor removal cavity, where GBM cells acquire chemo-radioresistance. Characterization of the tumor border microenvironment is critical for improving prognosis in patients with GBM. Here, we compared microRNA (miRNA) expression in samples from the tumor, tumor border, and periphery by miRNA microarray. The top three of miRNAs showing higher expression in the tumor border were related to oligodendrocyte differentiation, and pathologically oligodendrocyte lineage cells were increased in the border, where macrophages and microglia also colocalized. Medium cultured with oligodendrocyte progenitor cells (OPCs) and macrophages induced stemness and chemo-radioresistance in GBM cells, similar to that produced by FGF1, EGF and HB-EGF, IL-1β, corresponding to OPCs and macrophages, respectively. Thus, OPCs and macrophages/microglia may form a glioma stem cell niche at the tumor border, representing a promising target for prevention of recurrence., Highlights • Most cases of glioblastoma recur in white matter around the removal cavity after total resection plus chemo-radiotherapy. • miRNAs showing characteristically higher expression in the tumor border were related to oligodendrocyte differentiation. • Increased oligodendrocyte progenitor cells and macrophages enhance stemness and chemo-radioresistance in glioma cells. Glioblastoma (GBM) occurs in adult brain and shows rapid growth and invasion. Despite intensive treatment, the mean 5-year survival rate is still

Published
2018

2. Oligodendrocyte Progenitor Cells and Macrophages/Microglia Produce Glioma Stem Cell Niches at the Tumor Border.

Author

Hide T, Komohara Y, Miyasato Y, Nakamura H, Makino K, Takeya M, Kuratsu JI, Mukasa A, and Yano S

Subjects
Brain Neoplasms genetics, Cell Communication drug effects, Cell Communication genetics, Cell Line, Tumor, Cell Lineage drug effects, Cell Survival drug effects, Culture Media, Conditioned pharmacology, Drug Resistance, Neoplasm drug effects, Drug Resistance, Neoplasm genetics, Gene Expression Regulation, Neoplastic drug effects, Glioma genetics, Humans, Macrophages drug effects, Macrophages metabolism, MicroRNAs metabolism, Microglia drug effects, Microglia metabolism, Neoplasm Recurrence, Local metabolism, Neoplasm Recurrence, Local pathology, Neoplastic Stem Cells drug effects, Neoplastic Stem Cells metabolism, Oligodendrocyte Precursor Cells drug effects, Oligodendrocyte Precursor Cells metabolism, Spheroids, Cellular drug effects, Spheroids, Cellular metabolism, Spheroids, Cellular pathology, White Matter pathology, Brain Neoplasms pathology, Glioma pathology, Macrophages pathology, Microglia pathology, Neoplastic Stem Cells pathology, Oligodendrocyte Precursor Cells pathology, Stem Cell Niche drug effects
Abstract

Glioblastoma (GBM) usually develops in adult brain white matter. Even after complete resection, GBM recurs around the tumor removal cavity, where GBM cells acquire chemo-radioresistance. Characterization of the tumor border microenvironment is critical for improving prognosis in patients with GBM. Here, we compared microRNA (miRNA) expression in samples from the tumor, tumor border, and periphery by miRNA microarray. The top three of miRNAs showing higher expression in the tumor border were related to oligodendrocyte differentiation, and pathologically oligodendrocyte lineage cells were increased in the border, where macrophages and microglia also colocalized. Medium cultured with oligodendrocyte progenitor cells (OPCs) and macrophages induced stemness and chemo-radioresistance in GBM cells, similar to that produced by FGF1, EGF and HB-EGF, IL-1β, corresponding to OPCs and macrophages, respectively. Thus, OPCs and macrophages/microglia may form a glioma stem cell niche at the tumor border, representing a promising target for prevention of recurrence., (Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.)

Published
2018
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