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6. Biocompatibility and proteomic profiling of DMSA-coated iron nanocubes in a human glioblastoma cell line.

Author

Ulanova, Marina, Gloag, Lucy, Kim, Chul-Kyu, Bongers, Andre, Kim Duong, Hong Thien, Gooding, J Justin, Tilley, Richard D, Sachdev, Perminder S, and Braidy, Nady

Abstract

Background: Superparamagnetic iron core iron oxide shell nanocubes have previously shown superior performance in magnetic resonance imaging T2 contrast enhancement compared with spherical nanoparticles. Methods: Iron core iron oxide shell nanocubes were synthesized, stabilized with dimercaptosuccinic acid (DMSA-NC) and physicochemically characterized. MRI contrast enhancement and biocompatibility were assessed in vitro. Results: DMSA-NC showed a transverse relaxivity of 122.59 mM-1·s-1 Fe. Treatment with DMSA-NC did not induce cytotoxicity or oxidative stress in U-251 cells, and electron microscopy demonstrated DMSA-NC localization within endosomes and lysosomes in cells following internalization. Global proteomics revealed dysregulation of iron storage, transport, transcription and mRNA processing proteins. Conclusion: DMSA-NC is a promising T2 MRI contrast agent which, in this preliminary investigation, demonstrates favorable biocompatibility with an astrocyte cell model. MRI is a powerful tool used in the diagnosis of cancer, strokes and other injuries. An MRI scan can be improved with the use of iron oxide nanoparticles, which enhance the contrast of the image. In this study we have developed cube-shaped iron nanoparticles (nanocubes), which have been previously shown to be more effective at inducing contrast. We demonstrated that iron-based nanocubes do not damage or induce stress in cells and work effectively as an MRI contrast agent. We further analyzed how the nanocubes may affect cell functioning by investigating changes to protein levels in the cells. The results of this study are promising steps towards using iron-based nanocubes as a tool to improve the clarity of MRI scans for medical imaging and diagnosis. Future work must determine whether these nanocubes work effectively and safely in an animal model, which is a critical step in progressing to their use in clinical settings. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Evaluation of Dimercaptosuccinic Acid-Coated Iron Nanoparticles Immunotargeted to Amyloid Beta as MRI Contrast Agents for the Diagnosis of Alzheimer’s Disease

Author

Ulanova, Marina, primary, Gloag, Lucy, additional, Bongers, Andre, additional, Kim, Chul-Kyu, additional, Duong, Hong Thien Kim, additional, Kim, Ha Na, additional, Gooding, John Justin, additional, Tilley, Richard D., additional, Biazik, Joanna, additional, Wen, Wei, additional, Sachdev, Perminder S., additional, and Braidy, Nady, additional

Published
2023
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12. Introducing Stacking Faults into Three-Dimensional Branched Nickel Nanoparticles for Improved Catalytic Activity

Author

Ramadhan, Zeno R., primary, Poerwoprajitno, Agus R., additional, Cheong, Soshan, additional, Webster, Richard F., additional, Kumar, Priyank V., additional, Cychy, Steffen, additional, Gloag, Lucy, additional, Benedetti, Tania M., additional, Marjo, Christopher E., additional, Muhler, Martin, additional, Wang, Da-Wei, additional, Gooding, J. Justin, additional, Schuhmann, Wolfgang, additional, and Tilley, Richard D., additional

Published
2022
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16. Single Pt atoms on Ru nanoparticles for CO-resistant methanol oxidation reaction electrocatalysis

Author

Poerwoprajitno, Agus, primary, Gloag, Lucy, additional, Watt, John, additional, Cheong, Soshan, additional, Henson, Aaron, additional, Subhash, Bijil, additional, Bedford, Nicholas, additional, Miller, Benjamin, additional, O'Mara, Peter, additional, Benedetti, Tania, additional, Huber, Dale, additional, Gooding, John, additional, Schuhmann, Wolfgang, additional, and Tilley, Richard, additional

Published
2021
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21. Facettierte verzweigte Nickel‐Nanopartikel mit variierbarer Verzweigungslänge für die hochaktive elektrokatalytische Oxidation von Biomasse

Author

Poerwoprajitno, Agus R., primary, Gloag, Lucy, additional, Watt, John, additional, Cychy, Steffen, additional, Cheong, Soshan, additional, Kumar, Priyank V., additional, Benedetti, Tania M., additional, Deng, Chen, additional, Wu, Kuang‐Hsu, additional, Marjo, Christopher E., additional, Huber, Dale L., additional, Muhler, Martin, additional, Gooding, J. Justin, additional, Schuhmann, Wolfgang, additional, Wang, Da‐Wei, additional, and Tilley, Richard D., additional

Published
2020
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22. Faceted Branched Nickel Nanoparticles with Tunable Branch Length for High‐Activity Electrocatalytic Oxidation of Biomass

Author

Poerwoprajitno, Agus R., primary, Gloag, Lucy, additional, Watt, John, additional, Cychy, Steffen, additional, Cheong, Soshan, additional, Kumar, Priyank V., additional, Benedetti, Tania M., additional, Deng, Chen, additional, Wu, Kuang‐Hsu, additional, Marjo, Christopher E., additional, Huber, Dale L., additional, Muhler, Martin, additional, Gooding, J. Justin, additional, Schuhmann, Wolfgang, additional, Wang, Da‐Wei, additional, and Tilley, Richard D., additional

Published
2020
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26. Zero valent iron core–iron oxide shell nanoparticles as small magnetic particle imaging tracers

Author

Gloag, Lucy, primary, Mehdipour, Milad, additional, Ulanova, Marina, additional, Mariandry, Kevin, additional, Nichol, Muhammad Azrhy, additional, Hernández-Castillo, Daniela J., additional, Gaudet, Jeff, additional, Qiao, Ruirui, additional, Zhang, Ji, additional, Nelson, Melanie, additional, Thierry, Benjamin, additional, Alvarez-Lemus, Mayra A., additional, Tan, Thiam T., additional, Gooding, J. Justin, additional, Braidy, Nady, additional, Sachdev, Perminder S., additional, and Tilley, Richard D., additional

Published
2020
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32. Synthesis and characterisation of bimetallic Ru nanoparticles for efficient oxygen evolution reaction catalysis

Author

Gloag, Lucy

Subjects
Nanoparticles, Catalyst, Electrocatalysis
Abstract

Electrochemical water splitting is a critical reaction for the conversion of renewable energy sources. It is limited by the oxygen evolution reaction (OER) which requires high potentials to drive the reaction. The main drawback to OER catalysts is the trade-off between high activity at low potentials and stability over multiple uses. Ru metal has the lowest onset potential (∼1.3 V) and highest activity (100 - 4000 mA mg-1) due to the low energy barrier to Ru>4+ production that catalyses OER. Ru catalysts are limited by the immediate dissolution of the active species, resulting in catalysts that deteriorate in the first OER cycle. An OER electrode that delivers high activity at low potentials and remains active over multiple catalytic cycles remains a challenge. Synthesising a nanocatalyst with structural features that address both activity and stability separately offers a way to overcome this issue. This thesis focuses on creating nanoparticles with high electrochemically active surface areas made of low energy Ru surfaces. These can achieve both stability and activity by reducing the dissolution of Ru species from the highly accessible surfaces. Chapter 3 investigates the synthesis for Au-Ru branched nanoparticles with 3D branching and low index facets. By determining the key synthetic parameters to the formation of these structural features, a synthetic protocol is proposed. The growth of the Au-Ru branched nanoparticles is studied in chapter 4 using state-of-the-art transmission electron microscopy (TEM). The morphology and crystallography of intermediate nanoparticles are fully characterised to determine how these important structural features are formed. In chapter 5 the OER activity and stability of the Au-Ru branched nanoparticles are tested. Comparison to non-branched, non-faceted nanoparticles and TEM analysis of the nanoparticles after catalysis reveals the relationship between OER performance and structure. Chapter 6 investigates the synthesis of Pd-Ru bimetallic nanoparticles with core-shell and alloy structures as another means of achieving high electrochemically active surface areas and stable surfaces. By controlling synthetic variables a synthesis for nanoparticles with tunable size, shell thickness and composition is proposed for future optimisation as OER catalysts. Finally, conclusions are made across the synthesis, growth and OER performance of Ru-based bimetallic nanoparticles and opportunities for future work are proposed.

Published
2017
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33. Three-Dimensional Branched and Faceted Gold-Ruthenium Nanoparticles: Using Nanostructure to Improve Stability in Oxygen Evolution Electrocatalysis

Author

Gloag, Lucy, primary, Benedetti, Tania M., additional, Cheong, Soshan, additional, Li, Yibing, additional, Chan, Xuan-Hao, additional, Lacroix, Lise-Marie, additional, Chang, Shery L. Y., additional, Arenal, Raul, additional, Florea, Ileana, additional, Barron, Hector, additional, Barnard, Amanda S., additional, Henning, Anna M., additional, Zhao, Chuan, additional, Schuhmann, Wolfgang, additional, Gooding, J. Justin, additional, and Tilley, Richard D., additional

Published
2018
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36. Controlling the Number of Branches and Surface Facets of Pd-Core Ru-Branched Nanoparticles to Make Highly Active Oxygen Evolution Reaction Electrocatalysts.

Author

Myekhlai M, Benedetti TM, Gloag L, Poerwoprajitno AR, Cheong S, Schuhmann W, Gooding JJ, and Tilley RD

Abstract

Producing stable but active materials is one of the enduring challenges in electrocatalysis and other types of catalysis. Producing branched nanoparticles is one potential solution. Controlling the number of branches and branch size of faceted branched nanoparticles is one of the major synthetic challenges to achieve highly active and stable nanocatalysts. Herein, we use a cubic-core hexagonal-branch mechanism to synthesize branched Ru nanoparticles with control over the size and number of branches. This structural control is the key to achieving high exposure of active {10-11} facets and optimum number of Ru branches that enables improved catalytic activity for oxygen evolution reaction while maintaining high stability., (© 2020 Wiley-VCH GmbH.)

Published
2020
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37. Faceted Branched Nickel Nanoparticles with Tunable Branch Length for High-Activity Electrocatalytic Oxidation of Biomass.

Author

Poerwoprajitno AR, Gloag L, Watt J, Cychy S, Cheong S, Kumar PV, Benedetti TM, Deng C, Wu KH, Marjo CE, Huber DL, Muhler M, Gooding JJ, Schuhmann W, Wang DW, and Tilley RD

Subjects
Biomass, Catalysis, Furaldehyde chemistry, Oxidation-Reduction, Particle Size, Surface Properties, Furaldehyde analogs & derivatives, Metal Nanoparticles chemistry, Nickel chemistry
Abstract

Controlling the formation of nanosized branched nanoparticles with high uniformity is one of the major challenges in synthesizing nanocatalysts with improved activity and stability. Using a cubic-core hexagonal-branch mechanism to form highly monodisperse branched nanoparticles, we vary the length of the nickel branches. Lengthening the nickel branches, with their high coverage of active facets, is shown to improve activity for electrocatalytic oxidation of 5-hydroxymethylfurfural (HMF), as an example for biomass conversion., (© 2020 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.)

Published
2020
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38. Three-Dimensional Branched and Faceted Gold-Ruthenium Nanoparticles: Using Nanostructure to Improve Stability in Oxygen Evolution Electrocatalysis.

Author

Gloag L, Benedetti TM, Cheong S, Li Y, Chan XH, Lacroix LM, Chang SLY, Arenal R, Florea I, Barron H, Barnard AS, Henning AM, Zhao C, Schuhmann W, Gooding JJ, and Tilley RD

Abstract

Achieving stability with highly active Ru nanoparticles for electrocatalysis is a major challenge for the oxygen evolution reaction. As improved stability of Ru catalysts has been shown for bulk surfaces with low-index facets, there is an opportunity to incorporate these stable facets into Ru nanoparticles. Now, a new solution synthesis is presented in which hexagonal close-packed structured Ru is grown on Au to form nanoparticles with 3D branches. Exposing low-index facets on these 3D branches creates stable reaction kinetics to achieve high activity and the highest stability observed for Ru nanoparticle oxygen evolution reaction catalysts. These design principles provide a synthetic strategy to achieve stable and active electrocatalysts., (© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Published
2018
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