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The rapid increase in demand for renewable energy has led to a need for more efficient and effective ways to produce biogas from palm oil mill effluent (POME), which is rich in biological and chemical oxygen demand (BOD and COD). Despite its potential as a source of biogas, POME is not always effectively utilized in biogas production due to a lack of optimization of the treatment process. This study aims to address this issue by identifying the critical parameters affecting biogas production from POME and optimizing the process for maximum biogas yield and COD removal. This study employed comparative analysis and response surface methodology to optimize the performance of palm oil mill effluent (POME)-based biogas plants in Malaysia. Historical data from three commercial POME-based biogas plants in Malaysia were analyzed to identify the most critical parameters for biogas yield and COD removal. Response surface methodology, using Box–Behnken design and Design-Expert software, was then used to optimize these parameters. Sensitivity analysis was performed to interpret the impact of parameters on biogas production, with Organic Loading Rate (OLR) found to be the most critical factor for methane yield. The results showed that the optimum conditions for maximum methane production were OLR of 1.23 kg/m3·day, inlet Total Solids (TS) of 46,370 mg/L, pH of 4.5, and temperature of 45.4 °C, resulting in a 39.6% increase in methane yield (0.335 m3 CH4/kgCODremoved) and a 1.1% increase in COD removal (93.4%).

Incidence of microduplication 22q11.2 in patients referred for FISH testing for velo cardiofacial and DiGeorge syndromes