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41 results on '"Glover D.M."'

2. Revisiting the role of the mother centriole in centriole biogenesis

Author

Rodrigues-Martins, A., Riparbelli, M., Callaini, G., Glover, D.M., and Bettencourt-Dias, M.

Subjects
Centrioles -- Physiological aspects, Centrioles -- Chemical properties, Centrioles -- Natural history, Cell division -- Physiological aspects, Cellular control mechanisms -- Chemical properties, Protein kinases -- Physiological aspects
Published
2007

5. Interpolation of TCO2 data on a 1 degree x 1 degree grid throughout the water column below 500 m depth in the Atlantic Ocean

Author

Goyet, C., Healey, R., McCue, S.J., and Glover, D.M.

Subjects
Atlantic Ocean -- Research, Oceanographic research -- Atlantic Ocean, Oceanography -- Observations, Carbon cycle (Biogeochemistry) -- Research, Ocean circulation -- Research, Earth sciences
Abstract

Data compiled by TTO, SAVE and WOCE programs regarding Atlantic Ocean's carbonate system, temperature, salinity and oxygen were combined to parameterize TCO(sub 2) below 500 meters depth as a function of potential temperature, salinity and apparent oxygen utilization. With this interpolated TCO(sub 2) profile, current estimates of carbon content and ocean carbon transport have become more accurate. This method is found to be better than those using hydrographic and nutrient data.

Published
1997

8. Insight into the architecture of the nurd complex: Structure of the rbap48-mta1 subcomplex

Author

Alqarni, S.S., Murthy, A., Zhang, W., Przewloka, M.R., Silva, A.P., Watson, A.A., Lejon, S., Pei, X.Y., Smits, A.H., Kloet, S.L., Wang, H, Shepherd, N.E., Stokes, P.H., Blobel, G.A., Vermeulen, M., Glover, D.M., Mackay, J.P., and Laue, E.D.

Subjects
Proteomics and Chromatin Biology, Biophysics
Abstract

Contains fulltext : 135390.pdf (Publisher’s version ) (Open Access)

Published
2014

10. Life-cycle modification in open oceans accounts for genome variability in a cosmopolitan phytoplankton

Author

von Dassow, Peter, John, Uwe, Ogata, Hiroyuki, Probert, Ian, Bendif, E. M., Kegel, Jessica, Audic, S, Wincker, Patrick, Da Silva, C., Claverie, Jean-Michel, Doney, S, Glover, D.M., Flores, D.M., Herrera, Y, Lescot, M, Garet-Delmas, M.J., de Vargas, Colomban, von Dassow, Peter, John, Uwe, Ogata, Hiroyuki, Probert, Ian, Bendif, E. M., Kegel, Jessica, Audic, S, Wincker, Patrick, Da Silva, C., Claverie, Jean-Michel, Doney, S, Glover, D.M., Flores, D.M., Herrera, Y, Lescot, M, Garet-Delmas, M.J., and de Vargas, Colomban

Abstract

Emiliania huxleyi is the most abundant calcifying plankton in modern oceans with substantial intraspecific genome variability and a biphasic life cycle involving sexual alternation between calcified 2N and flagellated 1N cells. We show that high genome content variability in Emiliania relates to erosion of 1N-specific genes and loss of the ability to form flagellated cells. Analysis of 185 E. huxleyi strains isolated from world oceans suggests that loss of flagella occurred independently in lineages inhabiting oligotrophic open oceans over short evolutionary timescales. This environmentally linked physiogenomic change suggests life cycling is not advantageous in very large/diluted populations experiencing low biotic pressure and low ecological variability. Gene loss did not appear to reflect pressure for genome streamlining in oligotrophic oceans as previously observed in picoplankton. Life-cycle modifications might be common in plankton and cause major functional variability to be hidden from traditional taxonomic or molecular markers.

Published
2015

11. Discovery and Characterisation of 2-Anilino-4-(thiazol-5-yl) pyrimidine Transcriptional CDK Inhibitors as Anticancer Agents

Author

Wang, S., primary, Griffiths, G., additional, Midgley, C.A., additional, Barnett, A.L., additional, Cooper, M., additional, Grabarek, J., additional, Ingram, L., additional, Jackson, W., additional, Kontopidis, G., additional, McClue, S.J., additional, McInnes, C., additional, McLachlan, J., additional, Meades, C., additional, Mezna, M., additional, Stuart, I., additional, Thomas, M.P., additional, Zheleva, D.I., additional, Lane, D.P., additional, Jackson, R.C., additional, Glover, D.M., additional, Blake, D.G., additional, and Fischer, P.M., additional

Published
2010
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28. Parasites in Drosophila embryos

Author

Glover, D.M., Raff, J., Karr, T.L., O'Neill, S.L., Lin, H., and Wolfner, M.F.

Subjects
Drosophila, Environmental issues, Science and technology, Zoology and wildlife conservation
Published
1990

30. Mutations at the asp locus of Drosophila lead to multiple free centrosomes in syncytial embryos, but restrict centrosome duplication in larval neuroblasts

Author

Gonzalez, C., Saunders, R.D., Casal, J., Molina, I., Carmena, M., Ripoll, P., and Glover, D.M.

Abstract

Mutations at abnormal spindle result in abnormally long and wavy microtubules in the meiotic spindles of males. Some of these spindles have a single pole and take the form of unopposed hemi-spindles. Unfertilised eggs produced by homozygous asp females may have either no nuclei, or a small number of large nuclei, consistent with there also being an effect upon female meiosis. Such eggs also display free centrosomes and independent arrays of microtubules. Embryos that have this phenotype are also present among the progeny of fertilised homozygous asp females, together with embryos that undergo varying degrees of aberrant morphogenesis, developing a variety of abnormal cuticle patterns. This latter category shows asynchronous mitoses prior to cellularisation, and has abnormal arrays of spindle microtubules. Such embryos can develop large areas that are either devoid of or have a reduced number of nuclei, in which there are centrosomes that have dissociated from the mitotic spindles. Neuroblasts in the brains of homozygous asp larvae display a high mitotic index, and have condensed chromosomes aligned as if blocked at metaphase. Immunostaining reveals that many cells contain a single centrosome connected to the metaphase chromosomes by microtubules in a hemi-spindle-like structure.

Published
1990
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32. Isolation of a human tissue-type plasminogen-activator genomic DNA clone and its expression in mouse L-cells.

Author

Brown, M.J. (Morris), Tyrrell, A.W.R., Chapman, C.G., Carey, J.E. (Janet), Glover, D.M., Grosveld, F.G. (Frank), Dodd, I., Robinson, J.H., Brown, M.J. (Morris), Tyrrell, A.W.R., Chapman, C.G., Carey, J.E. (Janet), Glover, D.M., Grosveld, F.G. (Frank), Dodd, I., and Robinson, J.H.

Abstract

We have isolated a cDNA clone corresponding to a substantial portion of the human tissue-type plasminogen activator (t-PA) protein. It encodes almost all of the protein B chain and part of the 3' untranslated region. We have used this clone to screen bacteriophage lambda and cosmid libraries of human genomic DNA. Several related genomic clones were isolated. One of these, a cosmid clone, carried approx. 40 kb of human DNA. Mapping experiments indicate that the region containing the protein-coding exons is approx. 20 kb in length. The cosmid, containing the t-PA gene and the aminoglycosyl-3'-phosphotransferase dominant-selection marker, was introduced into mouse L cells. Approximately half of the transformants were shown to produce human t-PA. We demonstrated that the fibrinolytic t-PA activity could be specifically quenched by anti-t-PA antibody and that the recombinant t-PA was of similar size (by SDS-polyacrylamide gel electrophoresis) to the t-PA produced by the human Bowes melanoma cell line. Our results suggest that the cosmid clone carries the whole t-PA coding region together with the regulatory elements necessary for its expression.

Published
1985

41. Constitutive regulation of mitochondrial morphology by Aurora A kinase depends on a predicted cryptic targeting sequence at the N-terminus

Author

David M. Glover, Ahmed Abdelfattah, Jörg Mansfeld, Maria P. Gavilan, Catherine Lindon, Alessia Bertoldi, Rhys Grant, Grant R., Abdelbaki A., Bertoldi A., Gavilan M.P., Mansfeld J., Glover D.M., Lindon C., Mansfeld, Jörg [0000-0002-0562-8206], Lindon, Catherine [0000-0003-3554-2574], and Apollo - University of Cambridge Repository

Subjects
0301 basic medicine, Proteomics, Cytoplasm, Immunology, Protein Kinase Inhibitor, Library science, General Biochemistry, Genetics and Molecular Biology, Cell Line, Mitochondrial Proteins, aurka, 03 medical and health sciences, Mitochondrial dynamic, Political science, Mitochondrial Protein, media_common.cataloged_instance, Humans, European commission, European union, Erasmus+, Protein Kinase Inhibitors, lcsh:QH301-705.5, media_common, Aurora Kinase A, AURKA, General Neuroscience, European research, Research, mitochondrial dynamics, mitochondria, 030104 developmental biology, lcsh:Biology (General), Human, Research Article, Protein Binding
Abstract

Aurora A kinase (AURKA) is a major regulator of mitosis and an important driver of cancer progression. The roles of AURKA outside of mitosis, and how these might contribute to cancer progression, are not well understood. Here, we show that a fraction of cytoplasmic AURKA is associated with mitochondria, co-fractionating in cell extracts and interacting with mitochondrial proteins by reciprocal co-immunoprecipitation. We have also found that the dynamics of the mitochondrial network are sensitive to AURKA inhibition, depletion or overexpression. This can account for the different mitochondrial morphologies observed in RPE-1 and U2OS cell lines, which show very different levels of expression of AURKA. We identify the mitochondrial fraction of AURKA as influencing mitochondrial morphology, because an N-terminally truncated version of the kinase that does not localize to mitochondria does not affect the mitochondrial network. We identify a cryptic mitochondrial targeting sequence in the AURKA N-terminus and discuss how alternative conformations of the protein may influence its cytoplasmic fate.

Published
2018

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