19 results on '"Goñi-Irigoyen, Fernando"'
Search Results
2. Chemical and in vitro bioanalytical assessment of drinking water quality in Manhiça, Mozambique
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Villanueva, Cristina M., Grau-Pujol, Berta, Evlampidou, Iro, Escola, Valdemiro, Goñi-Irigoyen, Fernando, Kuckelkorn, Jochen, Grummt, Tamara, Arjona, Lourdes, Lazaro, Beatriz, Etxeandia, Arsenio, Ulibarrena, Enrique, Nhacolo, Ariel, and Muñoz, Jose
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- 2021
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3. Prognostic biomarkers of Parkinson’s disease in the Spanish EPIC cohort: a multiplatform metabolomics approach
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Gonzalez-Riano, Carolina, Saiz, Jorge, Barbas, Coral, Bergareche, Alberto, Huerta, José Mª, Ardanaz, Eva, Konjevod, Marcela, Mondragon, Elisabet, Erro, M. E., Chirlaque, M. Dolores, Abilleira, Eunate, Goñi-Irigoyen, Fernando, and Amiano, Pilar
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- 2021
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4. Plasma concentrations of persistent organic pollutants and pancreatic cancer risk
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Porta, Miquel, Gasull, M., Pumarega, J., Kiviranta, Hannu, Rantakokko, Panu, Raaschou-Nielsen, Ole, Bergdahl, Ingvar A, Sandanger, Torkjel Manning, Agudo, Antonio, Rylander, Charlotta, Nøst, Therese Haugdahl, Aune, Dagfinn, Heath, A.K., Cirera, Lluis, Goñi-Irigoyen, Fernando, Alguacil, Juan, Gimenez-Robert, Alex, Tjonneland, Anne, Sund, Malin, Overvad, Kim, Mancini, Francesca Romana, Rebours, V., Boutron-Ruault, Marie Christine, Kaaks, Rudolf, Schulze, M.B., Trichopoulou, Antonia, Palli, Domenico, Grioni, Sara, Tumino, Rosario, Naccarati, Alessio, Panico, Salvatore, Vermeulen, Roel, Quiros, J.R., Rodriguez-Barranco, Miguel, Colorado-Yohar, Sandra, Chirlaque, Maria Dolores, Ardanaz, Eva, Wareham, Nick J, Key, Timothy, Johansson, Mattias, Murphy, Neil, Ferrari, Pietro, Huybrechts, Inge, Chajes, V., González, Carlos A., Bas Bueno-de-Mesquita, Bas Bueno-de-Mesquita, Gunter, M.J., Weiderpass, Elisabete, Riboli, Elio, Duell, Eric J., Katzke, Verena, Vineis, Paolo, and IRAS OH Epidemiology Chemical Agents
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biomarkers ,environmental health ,Pancreatic cancer ,persistent organic pollutants ,methods - Abstract
Background: Findings and limitations of previous studies on persistent organic pollutants (POPs) and pancreatic cancer risk support conducting further research in prospective cohorts. Methods: We conducted a prospective case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Participants were 513 pancreatic cancer cases and 1020 matched controls. Concentrations of 22 POPs were measured in plasma collected at baseline. Results: Some associations were observed at higher concentrations of p, p'-DDT, trans-nonachlor, β-hexachlorocyclohexane and the sum of six organochlorine pesticides and of 16 POPs. The odds ratio (OR) for the upper quartile of trans-nonachlor was 1.55 (95% confidence interval 1.06-2.26; P for trend = 0.025). Associations were stronger in the groups predefined as most valid (participants having fasted >6 h, with microscopic diagnostic confirmation, normal weight, and never smokers), and as most relevant (follow-up ≥10 years). Among participants having fasted >6 h, the ORs were relevant for 10 of 11 exposures. Higher ORs were also observed among cases with microscopic confirmation than in cases with a clinical diagnosis, and among normal-weight participants than in the rest of participants. Among participants with a follow-up ≥10 years, estimates were higher than in participants with a shorter follow-up (for trans-nonachlor: OR = 2.14, 1.01 to 4.53, P for trend = 0.035). Overall, trans-nonachlor, three PCBs and the two sums of POPs were the exposures most clearly associated with pancreatic cancer risk. Conclusions: Individually or in combination, most of the 22 POPs analysed did not or only moderately increased the risk of pancreatic cancer.
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- 2022
5. Swimming Pool Water Disinfection By-Products Profiles and Association Patterns
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Abilleira, Eunate, primary, Goñi-Irigoyen, Fernando, additional, Aurrekoetxea, Juan José, additional, Cortés, María Adoración, additional, Ayerdi, Mikel, additional, and Ibarluzea, Jesús, additional
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- 2022
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6. Plasma concentrations of persistent organic pollutants and pancreatic cancer risk
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Porta, Miquel, primary, Gasull, Magda, additional, Pumarega, José, additional, Kiviranta, Hannu, additional, Rantakokko, Panu, additional, Raaschou-Nielsen, Ole, additional, Bergdahl, Ingvar A, additional, Sandanger, Torkjel Manning, additional, Agudo, Antoni, additional, Rylander, Charlotta, additional, Nøst, Therese Haugdahl, additional, Donat-Vargas, Carolina, additional, Aune, Dagfinn, additional, Heath, Alicia K, additional, Cirera, Lluís, additional, Goñi-Irigoyen, Fernando, additional, Alguacil, Juan, additional, Giménez-Robert, Àlex, additional, Tjønneland, Anne, additional, Sund, Malin, additional, Overvad, Kim, additional, Mancini, Francesca Romana, additional, Rebours, Vinciane, additional, Boutron-Ruault, Marie-Christine, additional, Kaaks, Rudolf, additional, Schulze, Matthias B, additional, Trichopoulou, Antonia, additional, Palli, Domenico, additional, Grioni, Sara, additional, Tumino, Rosario, additional, Naccarati, Alessio, additional, Panico, Salvatore, additional, Vermeulen, Roel, additional, Quirós, J Ramón, additional, Rodríguez-Barranco, Miguel, additional, Colorado-Yohar, Sandra M, additional, Chirlaque, María-Dolores, additional, Ardanaz, Eva, additional, Wareham, Nick, additional, Key, Tim, additional, Johansson, Mattias, additional, Murphy, Neil, additional, Ferrari, Pietro, additional, Huybrechts, Inge, additional, Chajes, Veronique, additional, Gonzalez, Carlos Alberto, additional, Bueno-de-Mesquita, Bas, additional, Gunter, Marc, additional, Weiderpass, Elisabete, additional, Riboli, Elio, additional, Duell, Eric J, additional, Katzke, Verena, additional, and Vineis, Paolo, additional
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- 2021
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7. Searching for prognostic biomarkers of Parkinson’s Disease development in the Spanish EPIC cohort through a multiplatform metabolomics approach
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Gonzalez-Riano, Carolina, primary, Saiz, Jorge, additional, Barbas, Coral, additional, Bergareche, Alberto, additional, Huerta, José Ma, additional, Ardanaz, Eva, additional, Konjevod, Marcela, additional, Mondragon, Elisabet, additional, Erro, ME, additional, Chirlaque, M. Dolores, additional, Abilleira, Eunate, additional, Goñi-Irigoyen, Fernando, additional, and Amiano, Pilar, additional
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- 2021
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8. Prenatal exposure to endocrine disrupting chemicals and risk of being born small for gestational age: Pooled analysis of seven European birth cohorts
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Govarts, Eva, Iszatt, Nina, Trnovec, Tomas, de Cock, Marijke, Eggesbø, Merete, Palkovicova Murinova, Lubica, van de Bor, Margot, Guxens, Mònica, Chevrier, Cécile, Koppen, Gudrun, Lamoree, Marja, Hertz-Picciotto, Irva, Lopez-Espinosa, Maria Jose, Lertxundi, Aitana, Grimalt, Joan O., Torrent, Maties, Goñi-Irigoyen, Fernando, Vermeulen, Roel, Legler, Juliette, Schoeters, Greet, One Health Chemisch, One Health Toxicologie, dIRAS RA-1, dIRAS RA-2, Vlaamse Instelling voor Technologisch Onderzoek [Mol] (VITO), Norwegian Institute of Public Health [Oslo] (NIPH), Slovak Medical University of Bratislava (SMU), VU University Amsterdam, CIBER de Epidemiología y Salud Pública (CIBERESP), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), University of California [Los Angeles] (UCLA), University of California, University of the Basque Country/Euskal Herriko Unibertsitatea (UPV/EHU), Institute of Environmental Assessment and Water Research (IDAEA), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), University Medical Center [Utrecht], University of Southern Denmark (SDU), OBELIX no 227391, FP7, Seventh Framework Programme, European Project: 227391,EC:FP7:KBBE,FP7-KBBE-2008-2B,OBELIX(2009), One Health Chemisch, One Health Toxicologie, dIRAS RA-1, dIRAS RA-2, Vrije Universiteit Amsterdam [Amsterdam] (VU), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), University of California (UC), Child and Adolescent Psychiatry / Psychology, Chard-Hutchinson, Xavier, OBesogenic Endocrine disrupting chemicals: LInking prenatal eXposure to the development of obesity later in life - OBELIX - - EC:FP7:KBBE2009-05-01 - 2013-11-30 - 227391 - VALID, E&H: Environmental Health and Toxicology, AIMMS, E&H: Environmental Bioanalytical Chemistry, Vrije universiteit = Free university of Amsterdam [Amsterdam] (VU), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de la Santé et de la Recherche Médicale (INSERM)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université d'Angers (UA)
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0301 basic medicine ,Male ,medicine.medical_specialty ,Birth weight ,010501 environmental sciences ,Breast milk ,Endocrine Disruptors ,01 natural sciences ,Pooled analysis ,03 medical and health sciences ,SDG 3 - Good Health and Well-being ,Interquartile range ,Pregnancy ,Medicine ,[SDV.EE.SANT] Life Sciences [q-bio]/Ecology, environment/Health ,Humans ,Biology ,lcsh:Environmental sciences ,0105 earth and related environmental sciences ,General Environmental Science ,2. Zero hunger ,lcsh:GE1-350 ,[SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health ,Milk, Human ,business.industry ,Obstetrics ,Smoking ,Infant, Newborn ,Gestational age ,Environmental exposure ,Odds ratio ,Endocrine disrupting chemicals (EDCs) ,Infant, Low Birth Weight ,medicine.disease ,Fetal Blood ,3. Good health ,Chemistry ,Small for gestational age (SGA) ,030104 developmental biology ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,Maternal Exposure ,Prenatal Exposure Delayed Effects ,Small for gestational age ,Female ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,business - Abstract
Background and aims: There is evidence that endocrine disrupting chemicals (EDCs) have developmental effects at environmental concentrations. We investigated whether some EDCs are associated with the adverse birth outcome Small for Gestational Age (SGA). Methods: We used PCB 153, p,p'-DDE, HCB, PFOS and PFOA measured in maternal, cord blood or breast milk samples of 5446 mother-child pairs (subset of 693 for the perfluorinated compounds) from seven European birth cohorts (1997–2012). SGA infants were those with birth weight below the 10th percentile for the norms defined by gestational age, country and infant's sex. We modelled the association between measured or estimated cord serum EDC concentrations and SGA using multiple logistic regression analyses. We explored effect modification by child's sex and maternal smoking during pregnancy. Results: Among the 5446 newborns, 570 (10.5%) were SGA. An interquartile range (IQR) increase in PCB 153 was associated with a modestly increased risk of SGA (odds ratio (OR) of 1.05 [95% CI: 1.04–1.07]) that was stronger in girls (OR of 1.09 [95% CI: 1.04–1.14]) than in boys (OR of 1.03 [95% CI: 1.03–1.04]) (p-interaction = 0.025). For HCB, we found a modestly increased odds of SGA in girls (OR of 1.04 [95% CI: 1.01–1.07] per IQR increase), and an inverse association in boys (OR of 0.90 [95% CI: 0.85–0.95]) (p-interaction = 0.0003). Assessment of the HCB-sex-smoking interaction suggested that the increased odds of SGA associated with HCB exposure was only in girls of smoking mothers (OR of 1.18 [95% CI: 1.11–1.25]) (p-interaction = 0.055). Higher concentrations of PFOA were associated with greater risk of SGA (OR of 1.64 [95% CI: 0.97–2.76]). Elevated PFOS levels were associated with increased odds of SGA in newborns of mothers who smoked during pregnancy (OR of 1.63 [95% CI: 1.02–2.59]), while an inverse association was found in those of non-smoking mothers (OR of 0.66 [95% CI: 0.61–0.72]) (p-interaction = 0.0004). No significant associations were found for p,p'-DDE. Conclusions: Prenatal environmental exposure to organochlorine and perfluorinated compounds with endocrine disrupting properties may contribute to the prevalence of SGA. We found indication of effect modification by child's sex and smoking during pregnancy. The direction of the associations differed by chemical and these effect modifiers, suggesting diverse mechanisms of action and biological pathways. Keywords: Endocrine disrupting chemicals (EDCs), Small for gestational age (SGA), Pooled analysis
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- 2018
9. Changes in serum dioxin and PCB levels in residents around a municipal waste incinerator in Bilbao, Spain
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Zubero, Miren B., primary, Eguiraun, Elena, additional, Aurrekoetxea, Juan J., additional, Lertxundi, Aitana, additional, Abad, Esteban, additional, Parera, Jordi, additional, Goñi-Irigoyen, Fernando, additional, and Ibarluzea, Jesus, additional
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- 2017
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10. Association between exposure to organochlorine compounds and maternal thyroid status: Role of the iodothyronine deiodinase 1 gene
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Llop, Sabrina, primary, Murcia, Mario, additional, Alvarez-Pedrerol, Mar, additional, Grimalt, Joan O., additional, Santa-Marina, Loreto, additional, Julvez, Jordi, additional, Goñi-Irigoyen, Fernando, additional, Espada, Mercedes, additional, Ballester, Ferran, additional, Rebagliato, Marisa, additional, and Lopez-Espinosa, Maria-Jose, additional
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- 2017
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11. Chemical quality of tap water in Madrid: multicase control cancer study in Spain (MCC-Spain)
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Fernández-Navarro, Pablo, primary, Villanueva, Cristina M., additional, García-Pérez, Javier, additional, Boldo, Elena, additional, Goñi-Irigoyen, Fernando, additional, Ulibarrena, Enrique, additional, Rantakokko, Panu, additional, García-Esquinas, Esther, additional, Pérez-Gómez, Beatriz, additional, Pollán, Marina, additional, and Aragonés, Nuria, additional
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- 2016
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12. Organochlorine Compounds and Ultrasound Measurements of Fetal Growth in the INMA Cohort (Spain)
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Lopez-Espinosa, Maria-Jose, primary, Murcia, Mario, additional, Iñiguez, Carmen, additional, Vizcaino, Esther, additional, Costa, Olga, additional, Fernández-Somoano, Ana, additional, Basterrechea, Mikel, additional, Lertxundi, Aitana, additional, Guxens, Mònica, additional, Gascon, Mireia, additional, Goñi-Irigoyen, Fernando, additional, Grimalt, Joan O., additional, Tardón, Adonina, additional, and Ballester, Ferran, additional
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- 2016
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13. Prenatal Exposure To Organochlorine Pesticides And Neuropsychological Development In Preschool Children
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Lopez-Espinosa, Maria-Jose, primary, Costa, Olga, additional, Murcia, Mario, additional, Forns, Joan, additional, Andiarena, Ainara, additional, Goñi-Irigoyen, Fernando, additional, Tardon, Adonina, additional, Grimalt, Joan O, additional, and Ballester, Ferran, additional
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- 2015
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14. Plaguicidas y PCBs en suero en población general de Barakaldo posiblemente expuesta al hexaclorociclohexano entre 1947 y 2002
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Aurrekoetxea Agirre, Juan J., Zubero, M. Begoña, Jiménez García, Cristina, Goñi Irigoyen, Fernando, Cambra Contín, Koldo, Alonso Fustel, Eva, and Cadiñanos Díaz-Tejeiro, M. Concepción
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Urban population ,Blood ,Vigilancia de la población ,Población Urbana ,Exposición Ambiental ,Sangre ,Hidrocarburos Clorados ,Population surveillance ,Plaguicidas ,Pesticides ,Environmental exposure ,Chlorinated hydrocarbons - Abstract
Fundamentos: Una fábrica de lindano de Barakaldo generó múltiples vertidos de hexaclorociclohexano (HCH). Cerró en 1987 dejando 4.500Tm en su interior, no solucionándose el problema hasta 2002. Un proceso judicial requirió una evaluación epidemiológica de la posible contaminación. Este trabajo pretende medir la impregnación de COPs en la población cercana a la planta. Métodos: Estudio transversal, realizado en 2008, de 154 personas voluntarias de tres centros de salud de Barakaldo y 270 personas controles de Bilbao, Alonsotegi y Balmaseda. Se cuantificaron en suero ocho plaguicidas organoclorados y siete PCBs. Se utilizó la χ² para contrastar la asociación entre variables categóricas y la t de Student para comparar medias geométricas. Se ajustaron factores de confusión mediante regresión lineal. Resultados: Se detectaron 6,3 compuestos de media detectables por persona. No se cuantificaron PCB 52 y 101, α -HCH, β -Endosulfán y Heptacloro-Epóxido; el PCB 28, γ-HCH y p,p´-DDT en un 6,6, 0,9 y 8,05%; y el β -HCH , HCB, p,p´-DDE y PCB 118, 138, 153 y 180 en el 73,8, 87,3, 98,6, 59,2, 97,6, 98,6 y 98,6% de los individuos, respectivamente. Ajustando por la edad no se observaron niveles más elevados en Barakaldo que en la población control de β -HCH (beta= 0,02; EE= 0,07), ni de HCB, p,p´-DDE, PCB 118, 138, 153 y 180. Conclusiones: Seis años después de resolverse el problema de los residuos en la población cercana a la fábrica de producción y de un almacenamiento masivo de HCH, no se observaron niveles significativamente mayores de HCH, tras su ajuste por edad. Background: A plant of lindane in Barakaldo produced discharges of hexachlorocyclohexane (HCH). Closed in 1987 leaving inside 4500Tm; the problem was not solved until 2002. A judicial process required an epidemiological assessment of the possible contamination The aim of this study is to measure the degree of impregnation of the POPs in the nearby population. Methods: Cross-sectional study conducted in 2008, 154 volunteers from three health centres in Barakaldo and 270 controls from Bilbao, Alonsotegi and Balmaseda. We measured serum levels of eight organochlorine pesticides, and seven polychlorinated biphenyls (PCBs). We used the χ² test to study the association between categorical variables and t test of Student to compare geometric means. Confounding factors were adjusted using a linear regression model. Results: There was a detectable compound average of 6.3 per person. PCBs 52 and 101, α -HCH, β-endosulfan and heptachlor epoxide could not be quantified; PCB 28, γ-HCH and p, p'-DDT were detected in 6.6, 0.9 and 8.05 % of subjects respectively and the β-HCH, HCB, p, p'-DDE, and PCBs 118, 138, 153 and 180 in the 73.8, 87.3, 98.6, 59.2, 97.6, 98.6 y 98.6 % respectively. After adjusting for age, there were no higher levels of β-HCH in Barakaldo than in controls, (beta = 0.02, SE = 0.07), or HCB, p, p'-DDE, PCB 118, PCB 138, PCB 153 and PCB 180. Conclusion: Six years after having solved the problem near to the factory and storage of HCH, there was no significantly higher levels of HCH, after adjustment for age.
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- 2011
15. Chemical quality of tap water in Madrid: multicase control cancer study in Spain (MCC-Spain).
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Fernández-Navarro, Pablo, Villanueva, Cristina, García-Pérez, Javier, Boldo, Elena, Goñi-Irigoyen, Fernando, Ulibarrena, Enrique, Rantakokko, Panu, García-Esquinas, Esther, Pérez-Gómez, Beatriz, Pollán, Marina, and Aragonés, Nuria
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DRINKING water quality ,CANCER prevention ,DISINFECTION by-product ,NITRATE content of water ,WATER pollution ,BROMINE in water - Abstract
Chronic consumption of water, which contains contaminants, may give rise to adverse health effects. The Madrid region, covered by the population-based multicase-control (MCC-Spain) study, includes two drinking water supply areas. The different sources of the water, coupled together with the possible differences in water management, mean that there may be differences in drinking water quality. In the context of the MCC study, our aims were to describe contaminant concentrations in tap water drawn from various sampling points distributed around the region, assess these concentrations by reference to guideline values and study possible differences between the two supply areas. Tap water samples were collected from 34 sampling points in 7 towns in the Madrid region (19-29 April 2010), and 23 contaminants (metals, nitrates, disinfection by-product and Mutagen X levels) were quantified. We undertook a descriptive analysis of the contaminant concentrations in the water and compared them between the two water supply areas (Wilcoxon test). We created maps representing the distribution of the concentrations observed at water sampling points and assessed the correlations (Spearman's coefficient) between the different parameters measured. The concentrations of the contaminants were below guideline values. There were differences between the two supply areas in concentration of nitrates ( p value = 0.0051) and certain disinfection by-products. While there were positive correlations (rho >0.70) among some disinfection by-products, no correlations were found in metals or nitrates. The differences in nitrate levels could be linked to differences in farming/industrial activities in the catchment areas and in disinfection by-products might be related to the existence of different treatment systems or bromine content in source waters. [ABSTRACT FROM AUTHOR]
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- 2017
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16. Plaguicidas y PCBs en suero en población general de Barakaldo posiblemente expuesta al hexaclorociclohexano entre 1947 y 2002
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Aurrekoetxea Agirre, Juan J., primary, Begoña Zubero, M., additional, Jiménez García, Cristina, additional, Goñi Irigoyen, Fernando, additional, Cambra Contín, Koldo, additional, Alonso Fustel, Eva, additional, and Díaz-Tejeiro, M. Concepción Cadiñanos, additional
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- 2011
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17. Plasma concentrations of persistent organic pollutants and pancreatic cancer risk.
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Porta M, Gasull M, Pumarega J, Kiviranta H, Rantakokko P, Raaschou-Nielsen O, Bergdahl IA, Sandanger TM, Agudo A, Rylander C, Nøst TH, Donat-Vargas C, Aune D, Heath AK, Cirera L, Goñi-Irigoyen F, Alguacil J, Giménez-Robert À, Tjønneland A, Sund M, Overvad K, Mancini FR, Rebours V, Boutron-Ruault MC, Kaaks R, Schulze MB, Trichopoulou A, Palli D, Grioni S, Tumino R, Naccarati A, Panico S, Vermeulen R, Quirós JR, Rodríguez-Barranco M, Colorado-Yohar SM, Chirlaque MD, Ardanaz E, Wareham N, Key T, Johansson M, Murphy N, Ferrari P, Huybrechts I, Chajes V, Gonzalez CA, Bueno-de-Mesquita B, Gunter M, Weiderpass E, Riboli E, Duell EJ, Katzke V, and Vineis P
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- Case-Control Studies, Humans, Persistent Organic Pollutants, Environmental Pollutants, Pancreatic Neoplasms epidemiology, Pesticides, Polychlorinated Biphenyls
- Abstract
Background: Findings and limitations of previous studies on persistent organic pollutants (POPs) and pancreatic cancer risk support conducting further research in prospective cohorts., Methods: We conducted a prospective case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Participants were 513 pancreatic cancer cases and 1020 matched controls. Concentrations of 22 POPs were measured in plasma collected at baseline., Results: Some associations were observed at higher concentrations of p, p'-DDT, trans-nonachlor, β-hexachlorocyclohexane and the sum of six organochlorine pesticides and of 16 POPs. The odds ratio (OR) for the upper quartile of trans-nonachlor was 1.55 (95% confidence interval 1.06-2.26; P for trend = 0.025). Associations were stronger in the groups predefined as most valid (participants having fasted >6 h, with microscopic diagnostic confirmation, normal weight, and never smokers), and as most relevant (follow-up ≥10 years). Among participants having fasted >6 h, the ORs were relevant for 10 of 11 exposures. Higher ORs were also observed among cases with microscopic confirmation than in cases with a clinical diagnosis, and among normal-weight participants than in the rest of participants. Among participants with a follow-up ≥10 years, estimates were higher than in participants with a shorter follow-up (for trans-nonachlor: OR = 2.14, 1.01 to 4.53, P for trend = 0.035). Overall, trans-nonachlor, three PCBs and the two sums of POPs were the exposures most clearly associated with pancreatic cancer risk., Conclusions: Individually or in combination, most of the 22 POPs analysed did not or only moderately increased the risk of pancreatic cancer., (© The Author(s) 2021. Published by Oxford University Press on behalf of the International Epidemiological Association.)
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- 2022
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18. Prenatal exposure to endocrine disrupting chemicals and risk of being born small for gestational age: Pooled analysis of seven European birth cohorts.
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Govarts E, Iszatt N, Trnovec T, de Cock M, Eggesbø M, Palkovicova Murinova L, van de Bor M, Guxens M, Chevrier C, Koppen G, Lamoree M, Hertz-Picciotto I, Lopez-Espinosa MJ, Lertxundi A, Grimalt JO, Torrent M, Goñi-Irigoyen F, Vermeulen R, Legler J, and Schoeters G
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- Female, Fetal Blood chemistry, Humans, Infant, Newborn, Male, Milk, Human chemistry, Pregnancy, Smoking epidemiology, Endocrine Disruptors adverse effects, Infant, Low Birth Weight, Maternal Exposure, Prenatal Exposure Delayed Effects
- Abstract
Background and Aims: There is evidence that endocrine disrupting chemicals (EDCs) have developmental effects at environmental concentrations. We investigated whether some EDCs are associated with the adverse birth outcome Small for Gestational Age (SGA)., Methods: We used PCB 153, p,p'-DDE, HCB, PFOS and PFOA measured in maternal, cord blood or breast milk samples of 5446 mother-child pairs (subset of 693 for the perfluorinated compounds) from seven European birth cohorts (1997-2012). SGA infants were those with birth weight below the 10th percentile for the norms defined by gestational age, country and infant's sex. We modelled the association between measured or estimated cord serum EDC concentrations and SGA using multiple logistic regression analyses. We explored effect modification by child's sex and maternal smoking during pregnancy., Results: Among the 5446 newborns, 570 (10.5%) were SGA. An interquartile range (IQR) increase in PCB 153 was associated with a modestly increased risk of SGA (odds ratio (OR) of 1.05 [95% CI: 1.04-1.07]) that was stronger in girls (OR of 1.09 [95% CI: 1.04-1.14]) than in boys (OR of 1.03 [95% CI: 1.03-1.04]) (p-interaction = 0.025). For HCB, we found a modestly increased odds of SGA in girls (OR of 1.04 [95% CI: 1.01-1.07] per IQR increase), and an inverse association in boys (OR of 0.90 [95% CI: 0.85-0.95]) (p-interaction = 0.0003). Assessment of the HCB-sex-smoking interaction suggested that the increased odds of SGA associated with HCB exposure was only in girls of smoking mothers (OR of 1.18 [95% CI: 1.11-1.25]) (p-interaction = 0.055). Higher concentrations of PFOA were associated with greater risk of SGA (OR of 1.64 [95% CI: 0.97-2.76]). Elevated PFOS levels were associated with increased odds of SGA in newborns of mothers who smoked during pregnancy (OR of 1.63 [95% CI: 1.02-2.59]), while an inverse association was found in those of non-smoking mothers (OR of 0.66 [95% CI: 0.61-0.72]) (p-interaction = 0.0004). No significant associations were found for p,p'-DDE., Conclusions: Prenatal environmental exposure to organochlorine and perfluorinated compounds with endocrine disrupting properties may contribute to the prevalence of SGA. We found indication of effect modification by child's sex and smoking during pregnancy. The direction of the associations differed by chemical and these effect modifiers, suggesting diverse mechanisms of action and biological pathways., (Copyright © 2018 Elsevier Ltd. All rights reserved.)
- Published
- 2018
- Full Text
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19. [Exposure to lindane, other pesticides and organochlorines in the general population Barakaldo, Spain].
- Author
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Aurrekoetxea Agirre JJ, Zubero MB, Jiménez García C, Goñi Irigoyen F, Cambra Contín K, Alonso Fustel E, and Cadiñanos Díaz-Tejeiro MC
- Subjects
- Adult, Aged, Chi-Square Distribution, Cross-Sectional Studies, Environmental Exposure analysis, Female, Humans, Industrial Waste analysis, Linear Models, Male, Middle Aged, Population Surveillance, Spain, Urban Population, Environmental Exposure statistics & numerical data, Environmental Pollutants blood, Hexachlorocyclohexane blood, Hydrocarbons, Chlorinated blood, Insecticides blood, Polychlorinated Biphenyls blood
- Abstract
Background: A plant of lindane in Barakaldo produced discharges of hexachlorocyclohexane (HCH). Closed in 1987 leaving inside 4500Tm; the problem was not solved until 2002. A judicial process required an epidemiological assessment of the possible contamination The aim of this study is to measure the degree of impregnation of the POPs in the nearby population., Methods: Cross-sectional study conducted in 2008, 154 volunteers from three health centres in Barakaldo and 270 controls from Bilbao, Alonsotegi and Balmaseda. We measured serum levels of eight organochlorine pesticides, and seven polychlorinated biphenyls (PCBs). We used the χ² test to study the association between categorical variables and t test of Student to compare geometric means. Confounding factors were adjusted using a linear regression model., Results: There was a detectable compound average of 6.3 per person. PCBs 52 and 101, α -HCH, β-endosulfan and heptachlor epoxide could not be quantified; PCB 28, γ-HCH and p, p'-DDT were detected in 6.6, 0.9 and 8.05 % of subjects respectively and the β-HCH, HCB, p, p'-DDE, and PCBs 118, 138, 153 and 180 in the 73.8, 87.3, 98.6, 59.2, 97.6, 98.6 y 98.6 % respectively. After adjusting for age, there were no higher levels of β-HCH in Barakaldo than in controls, (beta = 0.02, SE = 0.07), or HCB, p, p'-DDE, PCB 118, PCB 138, PCB 153 and PCB 180., Conclusion: Six years after having solved the problem near to the factory and storage of HCH, there was no significantly higher levels of HCH, after adjustment for age.
- Published
- 2011
- Full Text
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