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17. Comparison of fondaparinux and enoxaparin in acute coronary syndromes

Author

Yusuf, S., Mehta, S. R., Bassand, J. P., Budaj, A., Chrolavicius, S., Fox, K. A. A., Granger, C. B., Joyner, C., Peters, R. J. G., Wallentin, L., Avezum, A., Boden, W., Cardona, E., Ceremuzynski, L., Col, J., Commerford, P. J., Diaz, R., Faxon, D., Flather, M., Fodor, G., Franzosi, M. G., Granger, C., Halon, D., Hunt, D., Karatzas, N., Keltai, M., Kenda, M., Kim, J. H., Lanas, F., Lau, C. P., Lewis, B. S., Morais, J., Moccetti, T., Pais, P., Paolasso, E., Parkhomenko, A., Petrauskiene, B., Piegas, L., Pipilis, A., Robaayah, D., Ruda, M., Rumboldt, Z., Rupprecht, H. J., Sitkei, E., Steg, P. G., Swahn, E., Theroux, P., Valentin, V., Varigos, J., Weitz, J., White, H., Widimsky, P., Xavier, D., Zhu, J. R., Ameriso, S., Bonilla, C., Braekken, S., Chan, Y. K., Chen, W., Chenniappan, M., Cohen, E., Cottin, Y., Csiba, L., Czepiel, A., Raedt, H., Finet, G., Gardinale, E., Gaxiola, E., Gorecki, A., Gregor, P., Happola, O., Heras, M., Himbert, D., Irkin, O., Isaaz, K., Iyengar, S. S., Kalvach, P., Kevers, L., Klosiewicz-Wasek, B., Laine, M., Leys, D., Lundstrom, E., Lusic, I., Lutay, Y., Maggioni, A., Massaro, A., Mayosi, B. M., Moulin, T., Narendra, J., Naslund, U., Peeters, A., Penicka, M., Perakis, A., Petersen, P., Polic, S., Radhakrishnan, S., Renkin, J., Stockins, B., Sundararajan, R., Thygesen, K., Turazza, F., Belle, E., Vik-Mo, H., Zaborski, J., Sleight, P., Anderson, J. L., Johnstone, D. E., Hirsh, J., Demets, D., Holmes, D. R., Meeks, B., Afzal, R., Pogue, J., Boccalon, S., Chrysler, K., Cracknell, B., Horsman, C., Hoskin, T., Jedrzejowski, B., Johnson, J., Kotlan, S., Lawrence, M., Smiley, M., Stevens, C., Yallup, R., Connolly, S., Demers, C., Devereaux, P. J., Healey, J., Lonn, E., Magloire, P., Mckelvie, R., Morillo, C., Natarajan, M., Rokoss, M., Teo, K., Valettas, N., Velianou, J., Albisu, J. P., Amuchastegui, M., Bello, F. A., Bluguermann, J. J., Bono, J. O., Caccavo, A., Carlevaro, O. O., Cassettari, A., Cuneo, C., Farras, H. A., Fuselli, J., Garrido, M., Guerrero, R., Hasbani, E., Hominal, M. A., Hrabar, A., Marquez, L. L., Luciardi, H. L., Riera, L. M., Marzetti, E. M., Memoli, R., Nordaby, R., Orlandini, A. D., Perez, M., Piasentin, J. A., Ramos, H. R., Risolo, A. M., Sala, J., Salomone, O., Schygiel, P. O., Ubaldini, J., Vico, M., Amerena, J., Arnolda, L., Aroney, G., Boyd, P., Cahill, P., Chew, D., Counsell, J. T., Cross, D., Edington, J., Fitzpatrick, D., Hicks, P., Horowitz, J. D., Horrigan, M. C. G., New, G., Owensby, D., Schoeman, M., Thompson, P., Tulloch, G., Waites, J., Whelan, A., Ziffer, R., Huber, K., Jordanova, N., Al Shawafi, K., Convens, C., Coussement, P., Meester, A., El Allaf, D., Janssens, L., Marcovitch, O., Muyldermans, L., Roosen, J., Soeur, F., Lierde, J., Vrolix, M., Leaes, P., Carvalho, A. C., Schramm, E. C., Mora, R. D., Amino, J. D., Dutra, O., Manenti, E. R. F., Gun, C., Saraiva, J. F. K., Hayashi, E. K., Lichter, A., Lima, A., Marin-Neto, J. A., Teixeira, S. P. M., Abrantes, J. A. M., Baracioli, L. M., Nicolau, J. C., Maia, L. N., Jaeger, C. P., Esteves, J. P., Rabelo, A., Ramos, R. F., Reis, G., Rossi, P., Dos Santos, F. R., Teixeira, M. S., Silveira, D. S., Lemos, Mabt, Timerman, A., Greque, G. V., Vaz, R., Bhargava, R., Brons, S., Colclough, M., Constance, C., Costi, P., Dacyk, A., Davies, T., Diodati, J., Dupuis, R., Elliott, H., Fell, D. A., Fung, A. Y., Gladstone, P. J. S., Gosselin, G., Grondin, F., Huynh, T., Janzen, I., Kalaparambath, T., Kornder, J., Kouz, S., Kuritzky, R., Labelle-Stimac, S., Lamothe, M., Lauzon, C., Lemay, M., Ma, P., Maccallum, G. C., Mccallum, A., Mitchell, D., Montigny, M., Nguyen, N., Pearce, M., Pistawka, K. J., Rebane, T., Roy, M., Senaratne, M., Smith, J., Stimac, J., Traboulsi, M., Vizel, S., Weeks, A., Zadra, R., Zimmerman, R. H., Alcaino, M. E., Castro, P., Chen, J., Chen, J. L., Fan, W., Ge, J., Hu, D., Huang, J., Jingxuan, G., Ke, Y., Ma, H., Wu, Y., Yingxian, S., Yu, B., Zhu, W., Bakula, M., Bergovec, M., Lukin, A., Milicevic, G., Padovan, M., Raguz, M., Aschermann, M., Belohlavek, J., Bocek, P., Branny, M., Budesinsky, T., Groch, L., Holm, F., Jansky, P., Jelinek, P., Jirka, V., Kaislerova, M., Konecny, P., Lisa, L., Maly, M., Marcinek, G., Oscipovsky, M., Stumar, J., Vacha, M., Nielsen, T., Vigholt, E., Laanmets, P., Soopold, U., Voitk, J., Naveri, H., Niemela, M., Peuhkurinen, K., Tuomainen, P., Ylitalo, A., Py, A., Amat, G., Bessede, G., Boschat, J., Carrie, D., Charbonnier, B., Coliet, J. P., Dambrine, P., Dubois-Rande, J. L., Ferrari, E., Fouche, R., Grollier, G., Jaboureck, O., Ketelers, R., Khalife, K., Leroy, F., Lognone, T., Macquin-Mavier, I., Montalescot, G., Pacouret, G., Poulard, J. E., Puel, J., Richard, M., Schiele, F., Bischoff, K. O., Buerke, M., Buerke, U., Dominick, K., Drexler, H., Feiler, A., Guelker, H., Haltern, G., Katus, H. A., Klauss, V., Klutmann, M., Koeth, O., Meinhardt, G., Muenzel, T. M., Nitschke, T., Offterdinger, M., Rieber, J., Schieffer, B., Stangl, K., Stangl, V., Vom Dahl, J., Witzenbichler, B., Zeymer, U., Alexopoulos, D., Blassopoulou, N., Christon, A., Fotiadis, I., Foussas, S., Grapsas, N., Moschos, N., Papasteriadis, E., Symeonidis, D., Tyrologos, A., Leung, W. S., Li, S. K., Arabadzisz, H., Csikazs, J., Dancs, T., Davidovits, Z., Edes, I., Farkas, E., Herczeg, B., Janos, S., Janosi, A., Kadar, A., Kis, E., Kristof, E., Lupkovics, G., Mark, L., Nagy, A., Nagy, L., Poor, F., Regos, L., Sebo, J., Tomcsanyi, J., Toth, K., Bharani, A., Chidambaram, N., Haridas, K. K., Jain, A., Jain, P. R. K., Jaison, T. M., Kerkar, P. G., Naik, S., Nambiar, A., Panwar, R. B., Parikh, K., Puri, V. K., Rajesh, T., Ramesh, M., Singh, B., Thanikachalam, S., Tongia, R. K., Varma, S., Barbiero, M., Bardelli, G., Bernardi, D., Bolognese, L., Capponi, L., Ferrari, G., Fanelli, R., Frediani, L., Galli, M., Izzo, A., Lombardi, A., Maresta, A., Martinoni, A., Melloni, C., Meneghetti, P., Mennuni, M., Moretti, L., Orlandi, M., Pancaldi, L. G., Petronzelli, S., Piovaccari, G., Salvioni, A., Severini, D., Terrosu, P., Zanini, R., Erglis, A., Kalnins, U., Verboenko, J., Zakke, I., Kugiene, R., Zaliunas, R., Bin Othman, A., Chee, K. H., Hian, S. K., Gutierrez, A. C., Diaz, A. C., Garcia-Castillo, A., Guerrero, M. C., Morales, C. L., Ramos-Lopez, G., Baldew, S. C., Basart, D. C. G., Clappers, N., Daniels, M. C. G., Weerd, G. J., Den Hartog, F. R., Hendriks, Ihgm, Herrman, J. P. R., Kofflard, M., Krasznai, K., Michels, H. R., Stoel, I., Ten Berg, J. M., Umans, Vawn, Beek, G. J., Daele, Merm, Den Berg, B. J., Hessen, M. W. J., Kalmthout, P. M., Rossum, P., Verheugt, F. W. A., Viergever, E. P., Withagen, Ajam, Achremczyk, P., Arasimowicz, P., Baranowska, T., Biegayto, J., Bronisz, M., Buszman, P., Dalkowski, M., Dluzniewski, M., Gessek, J., Goch, J. H., Janik, K., Janion, M., Kawecki, D., Kleinrok, A., Komorowski, P., Krasowski, W., Krauze-Wielicka, M., Malinowski, S., Nowak, T., Nowakowski, P., Ogorek, M., Piepiorka, M., Pluta, W., Puzio, E., Puzniak, M., Rekosz, J., Rybka, P., Sendrowski, D., Siminiak, T., Skura, M., Stopinski, M., Szetemej, R., Szolkiewicz, M., Szpajer, M., Trusz-Gluza, M., Waszyrowski, T., Wita, K., Wodniecki, J., Wojewoda, P., Zambrzycki, J., Zielinski, Z., Cardoso, P., Carrageta, D. M., Ferreira, D., Gomes, M. V., Santos, L., Arkhipov, M., Belousov, Y., Charchoglyan, R., Gordeev, I. G., Gratsiansky, N. A., Grinshtein, Y., Khrustalev, O., Kokorin, V. A., Komarov, A., Kozulin, V., Minushkina, L. O., Panchenko, E., Panov, A., Petrik, E. S., Shakhnovich, R. M., Shalaev, S. V., Sukhinina, T. S., Trifonov, I. R., Zateyshchikov, D. A., Khoo, B. C. H., Tan, H. C., Tan, R. S., Hricak, V., Motovska, Z., Poliacik, P., Kanic, V., Kovacic, D., Kranjec, I., Voga, G., Bayat, J., Essop, M. R., Maritz, F., Marx, J. D., Ntsekhe, M., Pretorius, M. P., Ranjith, N., Theron, H., Chae, I. H., Chae, S. C., Choe, K. H., Chung, N. S., Jeong, M. H., Kim, C. J., Kim, H. S., Kim, W., Rhim, C. Y., Shin, E. K., Shin, G. J., Alameda, M., Alonso-Orcajo, N., Bethencourt, A., Calvo, F., Avellaneda, J. L. C., Delgado, V., Diaz-Castro, O., Esplugas, E., Faus, R., Antonio Fernandez-Ortiz, Frutos, A., Goirena, P., Iglesias, F. C., Llorian, A. R., Macaya, C., Mancisidor, X., Melgares, R., Pascual, C., Ruiz-Nodar, J. M., Simon, J. M., Agewall, S., Ahlstrom, P., Ali, M., Andersson, L., Bandh, S., Digerfeldt, C., Ericsson, H., Forsgren, M., Jabro, J., Janzon, M., Joborn, H., Johnston, N., Karlsson, J. E., Larsson, L. E., Linderfalk, C., Lonnberg, I., Mooe, T., Oldgren, J., Pihl, E., Risenfors, M., Sjolund, E., Soderberg, I., Stjerna, A., Svennberg, L., Wodlin, P., Pagnamenta, A., Pieper, M., Rossi, M. G., Weber, K., Peng, M. C., Cheng, J. J., Chiang, F. T., Kuo, C. T., Tseng, C. D., Andreyeshcheva, I., Dzyak, G. V., Fedtchouk, L., Gontar, A., Karpenko, O., Kononenko, L., Koval, E. A., Kovalsky, I., Kraitz, I., Netiazhenko, V., Polyvoda, S., Prokopenko, Y., Prudkiy, I., Rudenko, L., Serediuk, N., Zolotaykina, V., Adgey, J., Ahsan, A., Brack, M., Bridges, A. B., Burton, J., Findlay, I., Fluck, D. S., Radford, L., Robson, R. H., Senior, R., Starkey, I. R., Alexander, J., Baber, Z., Campbell, M., Caputo, R., Chandna, H., Chandrashekhar, Y., Chu, A., Deraad, R. E., Druken, B., Goyal, A., Holly, D., Kemp, A., Kotlaba, D., Levine, M. J., Miller, G. P., Nygaard, T., Parikh, D. K., Ramos, C., Rivera, E., Rodriguez, R., Sangani, B., Walder, J. S., and Oasis

20. Bifocal right ventricular pacing as an alternative treatment for patients with ventricular asynchrony and unsuccessful left ventricular implantation of cardiac resynchronization system,Stymulacja dwupunktowa prawej komory jako alternatywna metoda leczenia pacjentów z asynchronia lewokomorowa po nieudanej implantacji elektrody lewokomorowej układu resynchronizujacego

Author

Chudzik, M., Katarzyna Piestrzeniewicz, Wranicz, J. K., Oszczygieł, A., Klimczak, A., Goch, J. H., Ruciński, P., and Kutarski, A.

25. Relation between postoperative mortality and atrial fibrillation before surgical revascularization--3-year follow-up.

Author

Banach M, Goch A, Misztal M, Rysz J, Zaslonka J, Goch JH, and Jaszewski R

Subjects
Aged, Coronary Artery Bypass methods, Female, Follow-Up Studies, Humans, Length of Stay, Male, Middle Aged, Multivariate Analysis, Poland epidemiology, Postoperative Complications prevention & control, Survival Rate, Treatment Outcome, Atrial Fibrillation mortality, Coronary Artery Bypass mortality, Myocardial Revascularization mortality, Postoperative Complications mortality
Abstract

Background: Preoperative atrial fibrillation is one of the predictors of increased morbidity and mortality in patients undergoing surgical revascularization, and consequently, prolongs the duration of stay in the ICU and of overall hospitalization., Methods: The study included 3000 patients subjected to primary isolated coronary artery bypass grafting from 2000 to 2004. Of the 3000 patients, 5.8 % (n = 174) had electrocardiographically documented, preoperative atrial fibrillation. To evaluate the relationship between preoperative AF and postoperative outcome, all patients were observed for about three years., Results: Patients with preoperative atrial fibrillation were older (P < 0.05), had a lower ejection fraction (P < 0.001), a higher incidence of heart failure (P < 0.001), hypertension (P < 0.001), and more coexistent morbidities including diabetes (P < 0.05), obturative pulmonary disease (P < 0.0001) and mild renal failure (P < 0.001). Statistical analysis showed that survival rates at 6 and 30 days, 6 and 12 months, and 3 years following surgical revascularization of patients with vs. those without preoperative atrial fibrillation were: 96.4% vs. 98.1%, and 94.5% vs. 97.3% (P = ns), 86.2% vs. 93.0% (P < 0.03), and 74.7% vs. 91.0% (P < 0.02), and 70.7% vs. 90.6% (P < 0.01). After 3 years' observation there was a survival difference of 19.9%. We showed that preoperative atrial fibrillation triple increased the risk of postoperative AF and was an independent risk factor for in-hospital death (P < 0.001)., Conclusions: Preoperative atrial fibrillation is a predictor of postoperative complications, including death, and of a significant reduction in patients' long-term survival. Patients with preoperative atrial fibrillation should be considered as high-risk patients with potential postoperative complications and should be well protected with antiarrhythmic and anticoagulant therapy.

Published
2008
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26. Echocardiographic evaluation of the left atrium and left atrial appendage function in patients with atrial septum aneurysm: implications for thromboembolic complications.

Author

Goch A, Banach M, Piotrowski G, Szadkowska I, and Goch JH

Subjects
Adolescent, Adult, Aged, Atrial Appendage diagnostic imaging, Female, Follow-Up Studies, Heart Aneurysm complications, Heart Aneurysm physiopathology, Humans, Male, Middle Aged, Myocardial Contraction physiology, Prognosis, Retrospective Studies, Risk Factors, Thromboembolism diagnostic imaging, Atrial Appendage physiopathology, Atrial Function, Left physiology, Atrial Septum, Echocardiography, Doppler, Pulsed methods, Echocardiography, Transesophageal methods, Heart Aneurysm diagnostic imaging, Thromboembolism etiology
Abstract

Background: Our study aimed to assess left atrium (LA) and left atrial appendage (LAA) function in patients with atrial septum aneurysm (ASA) and to relate it to thromboembolic complications., Methods: The study group comprised 25 patients with isolated ASA (group I) and 17 clinically healthy subjects (control group = group II). Transthoracic and transesophageal echocardiography were performed in all investigated patients., Results: In group I, the following parameters were significantly higher than in the controls: LA minimal dimension (LA (min)) was 2.13 vs. 1.7 cm; LA presystolic dimension (LA (a)) was 2.66 vs. 2.29 cm and LA pre-ejection period/LA ejection time index (PEP/ETLA) was 1.26 vs. 0.41 ( P < 0.05). There were no statistically significant differences between groups as to P wave and PR-interval duration, which were 69 vs. 72 ms and 167 vs. 173 ms, respectively. All LAA parameters were investigated, but LAA minimal areas (LAA (area min)) were higher in the study group than in controls: LAA transversal dimension (LAA (trans)) was 1.89 vs. 1.32 cm; LAA longitudinal dimension (LAA (long)) was 4.24 vs. 3.11 cm; LAA maximal area (LAA (area max)) was 4.35 vs. 3.1 cm (2); LAA ejection fraction (EFLAA) was 56 vs. 33 %; LAA peak emptying (LAAE) was 0.64 vs. 0.41 m/s, and filling velocities (LAAF) was 0.55 vs. 0.42 m/s ( P < 0.05). The results indicate a depression of LA systolic and an enhancement of LAA function in patients with ASA compared with clinically healthy subjects., Conclusion: (1) Atrial septum aneurysm impairs left atrium systolic function. (2) In patients with atrial septum aneurysm, left atrium appendage function changes; its systolic as well as a reservoir function improve. (3) The enhancement of LAA function in ASA may be a compensatory mechanism for LA systolic function deterioration. (4) As LAA systolic function is enhanced, it is rather unlikely that LAA is the place of origin of thrombi, which occur relatively frequently (according to the literature) in patients with ASA. The thrombi seem to be formed in the bulging sack of ASA, i.e., in the part of the LA whose systolic function is depressed.

Published
2007
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27. Non-invasive methods of atrial function evaluation in heart diseases.

Author

Piotrowski G, Goch A, Wlazłowski R, Gawor Z, and Goch JH

Subjects
Atrial Natriuretic Factor physiology, Coronary Circulation, Echocardiography, Doppler, Electric Impedance, Heart Atria physiopathology, Heart Diseases diagnostic imaging, Hemodynamics, Humans, Natriuretic Peptide, Brain physiology, Pulmonary Circulation, Heart Diseases diagnosis, Heart Diseases physiopathology, Heart Function Tests methods
Abstract

The article describes four essential components (hemodynamic, bioelectrical, hormonal, metabolic) of atrial function. The role atria play in heart hemodynamic performance by virtue of their reservoir, conduit and active contractile function is emphasized. Next, the authors relate various non-invasive diagnostic methods in cardiology to the estimation of particular types of atrial function in physiological and in selected pathological conditions. Only non-invasive and easy accessible in clinical practice diagnostic methods are presented. The use of echocardiography for the evaluation of hemodynamic function of atria and left atrial appendage is particularly exposed.

Published
2000

28. [Effects of nitrates and beta-blockers on platelet aggregation in patients with coronary heart disease].

Author

Wlazłowski R, Kruszyński G, and Goch JH

Subjects
Adult, Aged, Dose-Response Relationship, Drug, Female, Humans, Male, Middle Aged, Treatment Outcome, Adrenergic beta-Antagonists pharmacology, Adrenergic beta-Antagonists therapeutic use, Coronary Disease drug therapy, Isosorbide Dinitrate pharmacology, Isosorbide Dinitrate therapeutic use, Platelet Aggregation drug effects, Propranolol pharmacology, Propranolol therapeutic use, Vasodilator Agents pharmacology, Vasodilator Agents therapeutic use
Abstract

Our study aimed at evaluating an effect of the selected nitrates and beta adrenoceptor blockers on platelet aggregation in patients (pts) with coronary artery disease (CAD). The study included 168 male patients (M), aged between 33 and 72 years (mean age 51 +/- 7). 61 M given isosorbide dinitrate were divided into three groups: in the group I and II an effect of the drug on the platelet aggregation following a single 10 mg (I) and 20 mg (II) dose has been evaluated; in group III an effect of the drug after a two-week treatment has been evaluated. 14 male patients (group IV) were given 5-mononitrate 40 mg daily for two weeks. 85 male patients, treated with propranolol have also been divided into three groups. In group V and group VII an effect of propranolol on platelet aggregation following a single dose of 40 mg and 80 mg has been evaluated respectively. In the group VII an outcome of a two-week propranolol therapy has been assessed. Eleven patients (group VIII) received nadolol in a dose of 40-80 mg daily for two weeks. Platelet aggregation induced by adenosine diphosphate (ADP) in concentration of 1 mM/ml and 5 mM/ml (groups I, II, III, V, VI, VII) and only of 1 microM/ml (groups IV, VIII) was evaluated with Born's method. In patients with CAD only isosorbide dinitrate inhibits platelet aggregation. This effect has been noted following a single dose as well as a two-week treatment. Other drugs (5-mononitrate, propranolol, nadolol) transiently increase platelet aggregation, but became either ineffective after two-week therapy (5-mononitrate, nadolol) or increase (propranolol) platelet aggregation. Tendency to inhibit (sorbonit) or to increase (propranolol) platelet aggregation has been more pronounced with higher concentration of aggregating factor.

Published
2000

29. [The influence of thrombolytic therapy on selected parameters of left ventricular function in acute myocardial infarction].

Author

Wrzesiński K, Kopaczewski J, Wlazłowski R, Gawor Z, and Goch JH

Subjects
Aged, Echocardiography, Female, Heart Ventricles diagnostic imaging, Humans, Male, Middle Aged, Myocardial Infarction diagnostic imaging, Myocardial Infarction physiopathology, Fibrinolytic Agents therapeutic use, Myocardial Infarction drug therapy, Thrombolytic Therapy, Tissue Plasminogen Activator therapeutic use, Ventricular Function, Left drug effects
Abstract

Our study aimed to evaluate the influence of thrombolytic therapy on some left ventricle (LV) function parameters in patients with acute myocardial infarction. The study was performed on 44 pts admitted to hospital due to acute myocardial infarction. The patients were divided into two groups: I group--30 pts (26 male, 4 female) at average age 57 +/- 10 who were treated with tissue plasminogen activator (t-PA) routinely and II group--14 pts (9 male, 5 female) at average age 62 +/- 10 in whom thrombolytic therapy was contraindicated for various reasons. Transthoracic echocardiography was performed just before treatment (0), 3.5 hours after the onset of drug administration (2 hours after the end of t-PA injection) (1) and on the 10th day of hospitalization (2). Control group consisted of 16 clinically healthy individuals (12 male, 4 female) at average age 54 +/- 9. The following parameters were evaluated: DT-E--wave of early diastolic transmitral flow deceleration time, IVRT--isovolumic relaxation time, E/A--early/atrial peak flow velocity ratio of transmitral flow, LATEF%--left atrial total emptying fraction, EF--left ventricle ejection fraction. In patients with acute myocardial infarction shortening of DT, prolongation of IVRT, lower E/A ratio and decrease of LATEF% compared to controls were observed. In group I EF was less than in clinically healthy individuals. E/A ratio was higher in pts from group I than from group II. In patients treated with t-PA 2 hours after treatment as well as on the 10th day significant prolongation of DT, shortening of IVRT and increase of LATEF% were observed. These changes were accompanied by the increase of EF. In patients with acute myocardial infarction not treated with t-PA significant increase in E/A ratio and EF on 10th day were observed. On the basis of the results were conclude: In patients with acute myocardial infarction LV diastolic function and with unproper relaxation as well as unproper compliance of LV myocardium is present. In patients with thrombolytic therapy LV filling pattern improves just two hours after t-PA administration (DT prolongation, IVRT shortening, LATEF% increase). Such tendency remains on the 10th day after treatment. In patients without thrombolytic therapy slight improvement occurs no sooner than on the 10th day of the MI.

Published
1999

30. [The significance of scintigraphic, echocardiographic and electrocardiographic left atrial transesophageal pacing in diagnosis of ischemic heart disease].

Author

Kowalczyk R, Gawor Z, Maziarz Z, Goch A, Drobiński R, Małkowski B, Grycewicz T, Goch JH, Kośmider M, and Adamus J

Subjects
Adult, Aged, Coronary Angiography, Echocardiography, Doppler, Electrocardiography, Exercise Test, Female, Heart Function Tests, Humans, Male, Middle Aged, Predictive Value of Tests, Radiopharmaceuticals, Sensitivity and Specificity, Technetium Tc 99m Sestamibi, Tomography, Emission-Computed, Single-Photon, Myocardial Ischemia diagnosis
Abstract

Unlabelled: The aim of the study was to compare the perfusion scintigraphy (using SPECT method with Tc-99-MIBI) during left atrial transoesophageal pacing test (LAPT) with pacing electrocardiography (ECG), echocardiography (ECHO) and electrocardiography exercise test (ExT) in ischaemic heart disease (IHD) diagnostics. The effect of LATP on heart haemodynamic parameters and the correlation between scintigraphic, echocardiographic and electrocardiographic parameters during LAPT test have been also assessed. Investigations were carried out in 55 subjects (Group I: 36 patients with effort angina pectoris; group II: controls: 19 clinically healthy subjects). Coronarography was performed in 24 patients 6 weeks before or after examinations. LATP test was analyzed with ECG, ECHO and SPECT. Echocardiography did not increase significantly the LATP test diagnostic value. Perfusion scintigraphy enhanced sensitivity and predictive excluding value LATP test. These values were 93.3% v 62.9% and 90% v 59.3% respectively. LATP test assessed with ECG, ECHO and perfusion scintigraphy expressed significantly higher sensitivity and predicting excluding value in comparison to ExT. LATP test analyzed in such way was characterized by 100% sensitivity and 100% predicting excluding value., Conclusion: Combination of LATP with electrocardiography, echocardiography and SPECT is a non-invasive high quality method for ischaemic heart disease diagnostics.

Published
1998

31. [Function of the left heart atrium during hemodialysis].

Author

Rysz J, Goch A, Zbróg Z, Goch JH, and Luciak M

Subjects
Adult, Echocardiography, Doppler, Female, Heart Function Tests, Humans, Male, Middle Aged, Weight Loss, Heart Atria diagnostic imaging, Uremia physiopathology, Uremia therapy
Abstract

In 23 chronic uremic patients effect of four-hour hemodialysis on function the left atrium of the heart was investigated. The reference group consisted of 17 healthy subjects. The function was evaluated by cross-sectional Doppler echocardiography. Before hemodialysis maximal (LAmax) and minimal (LAmin) left atrial dimensions and left atrial dimension obtained in M-mode of long axis in parasternal projection (LAa), pre-ejection period (PEPlp), ejection time (ETlp), PEPlo/ETlp ratio and left atrial fiber shortening fraction (FS%lp) were significantly higher in chronic uremic patients than those found in healthy subjects. Four-hour hemodialysis induced decreases in these indices, but only a lowering of LAa, PEPlp/ETlp ratio was statistically significant in comparison with pre-dialysis period. No correlation was found between changes of the investigated indices of the left atrial function and body weight loss during hemodialysis.

Published
1997

32. [Role of selenium in human pathophysiology].

Author

Andrzejak R, Goch JH, and Jurga M

Subjects
Adult, Animals, Glutathione Peroxidase metabolism, Humans, Infant, Male, Neoplasms prevention & control, Reference Values, Selenium deficiency, Neoplasms physiopathology, Selenium physiology
Abstract

Paper describes selenium metabolism and its function in physiological and pathological states. A role of selenium in development of human internal pathology with its action in suppressing the carcinogenesis is outlined. Function of selenium in biochemical structures is showed with a special stress put on glutathione peroxidase.

Published
1996

33. [A free radical mechanism for inhibition of arteriosclerosis development with calcium antagonists].

Author

Andrzejak R, Goch JH, and Jurga M

Subjects
Animals, Arteriosclerosis physiopathology, Calcium Channel Blockers pharmacology, Free Radicals metabolism, Humans, Arteriosclerosis drug therapy, Calcium Channel Blockers therapeutic use
Abstract

Work presents current views on involvement of free radicals in inhibition of development of arteriosclerosis by calcium antagonist (ACa). The importance of other substances, which interferes with calcium ions can contribute to the inhibition of arteriosclerosis development.

Published
1995

34. [Free radicals and their importance in medicine].

Author

Andrzejak R, Goch JH, and Jurga M

Subjects
Animals, Arteriosclerosis physiopathology, Free Radicals chemistry, Free Radicals metabolism, Humans, Kidney Diseases etiology, Kidney Diseases physiopathology, Respiratory Distress Syndrome etiology, Respiratory Distress Syndrome physiopathology, Superoxide Dismutase metabolism, Arteriosclerosis etiology, Free Radicals adverse effects
Abstract

The work presents current views of free radicals and their role in medicine. In the first fact, the chemical nature of free radicals, their reactions in cells and its consequences are discussed. The second part deals with a role of free radicals in human pathology with a special stress put an arteriosclerotic process. In the third part, the defense mechanism against free radical action, particularly the importance of superoxide dismutase.

Published
1995

35. [The value of 2-dimensional echocardiography in conjunction with various exercise tests for diagnosis of myocardial ischemia].

Author

Gawor Z and Goch JH

Subjects
Adult, Angina Pectoris diagnostic imaging, Angina Pectoris physiopathology, Cardiac Pacing, Artificial, Cold Temperature, Dipyridamole, Female, Humans, Male, Middle Aged, Myocardial Ischemia physiopathology, Ventricular Function, Left physiology, Echocardiography, Exercise Test, Hemodynamics physiology, Myocardial Ischemia diagnostic imaging
Abstract

In 16 persons of the control group (group I) and in 27 patients with coronary heart disease (group II) value of two-dimensional echocardiography was determined combined with exercise, transoesophageal left atrial pacing, dipyridamole and cold pressor tests in detecting myocardial ischaemia. Changes of ST-segment in the ECG, left ventricular ejection fraction and wall motion in the 11 segments were studied during the tests. Sensitivity, specificity and predictive value confirming and excluding ischaemic heart disease of the analyzed parameters were determined. The sensitivity and the specificity of exercise, left atrial pacing, dipyridamole and cold pressor tests during the analysis of ST-segment were 70%, 81%, 37%, 4% and 62%, 67%, 94%, 100%, respectively. Two-dimensional echocardiography analysis did not increase the diagnostic value of the exercise and left atrial pacing tests, whereas the diagnostic value of dipyridamole and cold pressor tests were increased.

Published
1993

37. [Neurohormonal mechanisms in congestive heart failure].

Author

Goch JH

Subjects
Cardiovascular System innervation, Catecholamines physiology, Heart Failure physiopathology, Humans, Arginine Vasopressin physiology, Atrial Natriuretic Factor physiology, Autonomic Nervous System physiopathology, Cardiovascular System physiopathology, Heart Failure etiology, Natriuretic Agents physiology, Renin-Angiotensin System physiology
Published
1992

38. Changes in platelet activity and tissue plasminogen activator during arteriography in patients with chronic limb ischaemia.

Author

Polanowska R, Wilczyńska M, Sławiński W, Goch JH, Augustyniak W, and Cierniewski CS

Subjects
Adult, Aged, Arteriosclerosis blood, Diatrizoate adverse effects, Diatrizoate Meglumine adverse effects, Drug Combinations, Fibronectins analysis, Humans, Leg diagnostic imaging, Male, Middle Aged, Platelet Factor 4 analysis, beta-Thromboglobulin analysis, Angiography adverse effects, Arteriosclerosis diagnostic imaging, Blood Platelets drug effects, Contrast Media adverse effects, Tissue Plasminogen Activator analysis
Published
1992
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39. [Platelet aggregation in patients with coronary disease treated with nifedipine].

Author

Tkaczewski W, Goch JH, Kruszyński G, and Ryniec A

Subjects
Adult, Aged, Coronary Disease drug therapy, Dose-Response Relationship, Drug, Female, Humans, Male, Middle Aged, Nifedipine administration & dosage, Platelet Aggregation physiology, Platelet Aggregation Inhibitors, Time Factors, Coronary Disease blood, Nifedipine therapeutic use, Platelet Aggregation drug effects
Abstract

The effect of nifedipine on the aggregation of blood platelets has been studied in patients with coronary heart disease. The study involved 78 males, aged between 36 and 64 years (mean age 51 years). The level of aggregation was evaluated before and after a single nifedipine dose of 10 mg (in 15 patients) and of 20 mg (in 34 patients) as well as before and after the treatment with nifedipine (of 29 patient) with a daily dose of 30 mg for two weeks. Aggregation of blood platelets induced by adenosine--diphosphate in of concentrations 1 microM/ml and of 5 microM/ml were estimated by the Born method. It was found that nifedipine reduces the aggregation of the blood platelets in patients with coronary heart disease following single and long-term treatment.

Published
1990

42. Myocardial contractility in healthy rabbits.

Author

Goch JH

Subjects
Animals, Female, Heart Function Tests, Heart Rate, Male, Rabbits, Systole, Ventricular Function, Myocardial Contraction
Abstract

In 75 healthy rabbits the systolic times intervals (STI) and their indexes of the left-ventricle were determined for establishing the normal range of these values. In the analysis the effects of the heart rate on the values of these parameters were taken into account. A correlation was found between the heart rate and the QT interval (r = -0.8673), total electromechanical systole - QS2 (r = -0.5557), heart sounds interval - S1S2 (r = -5696), left ventricular ejection time - LVET (r = -0.4745), pre-ejection period - PEP (r = -2288), isovolumic contraction time - ICT (r = -0.2570). No correlation was found between the heart rate and the electromechanical delay - Q-1 (r = -0.0226).

Published
1980

43. [Ergometric test in sympatheticotonia after administration of propranolol, pindolol, verapamil and oxazepam].

Author

Tkaczewski W, Goch JH, Wichan P, and Kowalski J

Subjects
Adolescent, Adrenergic Fibers drug effects, Adult, Clinical Trials as Topic, Exercise Test, Heart Failure drug therapy, Heart Failure physiopathology, Humans, Male, Adrenergic Fibers physiopathology, Heart innervation, Oxazepam therapeutic use, Pindolol therapeutic use, Propranolol therapeutic use, Verapamil therapeutic use
Published
1980

44. [Healing of gastric and duodenal ulcers during treatment with licorice extracts].

Author

Adamska-Dyniewska H, Goch JH, Chojnacki J, Chojnowska-Jezierska J, Bala T, Kowalczyk L, Rec A, and Jeziorska J

Subjects
Adolescent, Adult, Humans, Middle Aged, Plant Extracts pharmacology, Plant Extracts therapeutic use, Wound Healing drug effects, Duodenal Ulcer drug therapy, Glycyrrhiza, Plants, Medicinal, Stomach Ulcer drug therapy
Published
1975

46. [Brain glioma in a patient with systemic lupus erythematosus].

Author

Goch JH, Sekulski A, Rosiek S, and Wierciński J

Subjects
Brain Neoplasms etiology, Glioblastoma etiology, Humans, Male, Middle Aged, Brain Neoplasms diagnosis, Glioblastoma diagnosis, Lupus Erythematosus, Systemic complications
Published
1983

50. [Side effects following ingestion of non-steroid anti-inflammatory agents].

Author

Adamska-Dyniewska H, Chojnacki J, Chojnowska-Jezierska J, Goch JH, Kowalaczyk L, and Zydowicz L

Subjects
Adult, Aged, Anti-Inflammatory Agents therapeutic use, Aspirin adverse effects, Clinical Trials as Topic, Hallucinations chemically induced, Humans, Indomethacin adverse effects, Joint Diseases drug therapy, Mefenamic Acid adverse effects, Middle Aged, Placebos, Pyrazines adverse effects, Anti-Inflammatory Agents adverse effects
Published
1975

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