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244 results on '"Goetz, Andrew"'

1. Photo-essay from Operation Joint Endeavor, pt 2

Author

Goetz, Andrew, Maj

Subjects
ENGINEER UNITS - Army - Organization, OPERATION - Joint Endeavor - Lessons Learned, OPERATION - Joint Endeavor, PHOTOGRAPHY, MILITARY
Abstract

illus tab, Part 1, v26 (Aug 1996): p7-11; part 2, v26 (Dec 1996): p18-24

Published
1996

7. Comparison of N···I and N···O Halogen Bonds in Organoiodine Cocrystals of Heterocyclic Aromatic Diazine Mono-N-oxides

Author

Padgett, Clifford W., primary, Dean, Riley, additional, Cobb, Audrey, additional, Miller, Aubree, additional, Goetz, Andrew, additional, Bailey, Sam, additional, Hillis, Kyle, additional, McMillen, Colin, additional, Toney, Sydney, additional, Guillet, Gary L., additional, Lynch, Will, additional, and Pennington, William T., additional

Published
2024
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9. The Einstein-Klein-Gordon Equations, Wave Dark Matter, and the Tully-Fisher Relation

Author

Goetz, Andrew S.

Subjects
General Relativity and Quantum Cosmology, Astrophysics - Astrophysics of Galaxies
Abstract

We examine the Einstein equation coupled to the Klein-Gordon equation for a complex-valued scalar field. These two equations together are known as the Einstein-Klein-Gordon system. In the low-field, non-relativistic limit, the Einstein-Klein-Gordon system reduces to the Poisson-Schr\"odinger system. We describe the simplest solutions of these systems in spherical symmetry, the spherically symmetric static states, and some scaling properties they obey. We also describe some approximate analytic solutions for these states. The EKG system underlies a theory of wave dark matter, also known as scalar field dark matter (SFDM), boson star dark matter, and Bose-Einstein condensate (BEC) dark matter. We discuss a possible connection between the theory of wave dark matter and the baryonic Tully-Fisher relation, which is a scaling relation observed to hold for disk galaxies in the universe across many decades in mass. We show how fixing boundary conditions at the edge of the spherically symmetric static states implies Tully-Fisher-like relations for the states. We also catalog other "scaling conditions" one can impose on the static states and show that they do not lead to Tully-Fisher-like relations--barring one exception which is already known and which has nothing to do with the specifics of wave dark matter., Comment: This is a posting of my PhD thesis (Duke University Department of Mathematics, 2015). 73 pages, 17 figures, 3 tables

Published
2015

10. Tully-Fisher Scalings and Boundary Conditions for Wave Dark Matter

Author

Goetz, Andrew S.

Subjects
Astrophysics - Astrophysics of Galaxies, General Relativity and Quantum Cosmology
Abstract

We investigate a theory of dark matter called wave dark matter, also known as scalar field dark matter (SFDM) and boson star dark matter or Bose-Einstein condensate (BEC) dark matter (also see axion dark matter), and its relation to the Tully-Fisher relation. We exhibit two boundary conditions that give rise to Tully-Fisher-like relations for spherically symmetric static wave dark matter halos: (BC1) Fixing a length scale at the outer edge of wave dark matter halos gives rise to a Tully-Fisher-like relation of the form $M/v^4=\text{constant}$. (BC2) Fixing the density of dark matter at the outer edge of wave dark matter halos gives rise to a Tully-Fisher-like relation of the form $M/v^{3.4}=\text{const}$., Comment: 19 pages, 9 figures

Published
2015

11. Computational Modeling of Drug Response Identifies Mutant-Specific Constraints for Dosing panRAF and MEK Inhibitors in Melanoma.

Author

Goetz, Andrew, Shanahan, Frances, Brooks, Logan, Lin, Eva, Mroue, Rana, Dela Cruz, Darlene, Hunsaker, Thomas, Czech, Bartosz, Dixit, Purushottam, Segal, Udi, Martin, Scott, Foster, Scott A., and Gerosa, Luca

Subjects
*PROTEIN kinase inhibitors, *COMPUTER simulation, *IN vitro studies, *MELANOMA, *RESEARCH funding, *ANTINEOPLASTIC agents, *XENOGRAFTS, *CELLULAR signal transduction, *DESCRIPTIVE statistics, *DOSE-effect relationship in pharmacology, *MICE, *CELL lines, *BIOINFORMATICS, *ANIMAL experimentation, *WESTERN immunoblotting, *PROTEIN-tyrosine kinases, *GENETIC mutation, *INDIVIDUALIZED medicine
Abstract

Simple Summary: Combining drugs is crucial for enhancing anti-cancer responses. However, the potential of pre-clinical data in identifying suitable combinations and dosage is often underutilized. In this study, we leverage pre-clinical in vitro cell line drug response data and computational modeling of signal transduction and of pharmacokinetics to elucidate distinct dose requirements for the combination of pan-RAF and MEK inhibitors in melanoma. Our findings reveal a more synergistic but narrower dosing landscape in NRAS vs. BRAF mutant melanoma, which we link to a mechanism of adaptive resistance through negative feedback. Further, our analysis suggests the importance of drug dosing strategies to optimize synergy based on mutational context yet highlights the real-world challenges of maintaining a narrow dose range. This approach establishes a framework for translational investigation of drug responses in the refinement of combination therapy, balancing the potential for synergy and practical feasibility in cancer treatment planning. Purpose: This study explores the potential of pre-clinical in vitro cell line response data and computational modeling in identifying the optimal dosage requirements of pan-RAF (Belvarafenib) and MEK (Cobimetinib) inhibitors in melanoma treatment. Our research is motivated by the critical role of drug combinations in enhancing anti-cancer responses and the need to close the knowledge gap around selecting effective dosing strategies to maximize their potential. Results: In a drug combination screen of 43 melanoma cell lines, we identified specific dosage landscapes of panRAF and MEK inhibitors for NRAS vs. BRAF mutant melanomas. Both experienced benefits, but with a notably more synergistic and narrow dosage range for NRAS mutant melanoma (mean Bliss score of 0.27 in NRAS vs. 0.1 in BRAF mutants). Computational modeling and follow-up molecular experiments attributed the difference to a mechanism of adaptive resistance by negative feedback. We validated the in vivo translatability of in vitro dose–response maps by predicting tumor growth in xenografts with high accuracy in capturing cytostatic and cytotoxic responses. We analyzed the pharmacokinetic and tumor growth data from Phase 1 clinical trials of Belvarafenib with Cobimetinib to show that the synergy requirement imposes stricter precision dose constraints in NRAS mutant melanoma patients. Conclusion: Leveraging pre-clinical data and computational modeling, our approach proposes dosage strategies that can optimize synergy in drug combinations, while also bringing forth the real-world challenges of staying within a precise dose range. Overall, this work presents a framework to aid dose selection in drug combinations. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Wave Dark Matter and the Tully-Fisher Relation

Author

Bray, Hubert L. and Goetz, Andrew S.

Subjects
Astrophysics - Astrophysics of Galaxies, General Relativity and Quantum Cosmology
Abstract

We investigate a theory of dark matter called wave dark matter, also known as scalar field dark matter (SFDM) and boson star dark matter or Bose-Einstein condensate (BEC) dark matter, in spherical symmetry and its relation to the Tully-Fisher relation. We show that fixing the oscillation frequency of wave dark matter near the edge of dark galactic halos implies a Tully-Fisher-like relation for those halos. We then describe how this boundary condition, which is roughly equivalent to fixing the half-length of the exponentially decaying tail of each galactic halo mass profile, may yield testable predictions for this theory of dark matter., Comment: 19 pages, 4 figures

Published
2014

18. List of Contributors to Volume 5

Author

Marcucci, Edoardo, primary, Fageda, Xavier, additional, Olivieri, Cecilia, additional, Musselwhite, Charles B.A., additional, Scott, Theresa, additional, Holden, Erling, additional, Gilpin, Geoffrey, additional, Simoni, Michele D., additional, Kockelman, Kara M., additional, Maltese, Ila, additional, Zamparini, Luca, additional, van Wee, Bert, additional, Rodrigue, Jean-Paul, additional, Guerra, Erick, additional, Duranton, Gilles, additional, Tavasszya, Lóránt, additional, de Jongb, Gerard, additional, Bamberg, Sebastian, additional, Ajzen, Icek, additional, Schmidt, Peter, additional, Samaras, Zissis, additional, Vouitsis, Ilias, additional, Mackett, Roger L, additional, Pooley, Colin G., additional, Comi, Antonio, additional, Mindell, Jennifer S., additional, Mandic, Sandra, additional, Groth, Sören, additional, Kuhnimhof, Tobias, additional, Wolshon, Brian, additional, Schmöcker, Jan-Dirk, additional, Gerike, Regine, additional, Hubrich, Stefan, additional, Koszowski, Caroline, additional, Schröter, Bettina, additional, Wittwer, Rico, additional, Eisenmann, Christine, additional, Görges, Daniel, additional, Franke, Thomas, additional, Shaheen, Susan, additional, Kaplan, Sigal, additional, Cohen-Blankshtain, Galit, additional, Scheiner, Joachim, additional, Janić, Milan, additional, Hallion, Richard P., additional, Budd, Lucy, additional, Ison, Stephen, additional, Merkert, Rico, additional, Bushell, James, additional, Senn, Lanfranco, additional, Le Vine, Scott, additional, Pagliara, Francesca, additional, Martín, Juan Carlos, additional, Román, Concepción, additional, Forsyth, Peter, additional, Niemeier, Hans-Martin, additional, Czerny, Achim I., additional, Oliveira, Renan Peres de, additional, Lohmann, Gui, additional, Gudmundsson, Sveinn Vidar, additional, Bilotkach, Volodymyr, additional, Goetz, Andrew R., additional, Torre, Vincenzo, additional, Sollo, Antonio, additional, Domarchi, Cristian, additional, Ortúzar, Juan de Dios, additional, Schiller, Preston L., additional, Condeço-Melhorado, Ana M., additional, Manaugh, Kevin, additional, Diab, Ehab, additional, El-Geneidy, Ahmed, additional, Appleyard, Bruce, additional, Mallett, Zakhary, additional, Boarnet, Marlon G, additional, Arts, Jos, additional, Leendertse, Wim, additional, Tillema, Taede, additional, King, David A., additional, Krizek, Kevin J., additional, Percoco, Marco, additional, Veldstra, J.L., additional, Ãoenal, A.B., additional, Steg, E.M., additional, Ricci, Gysele Lima, additional, Bogenberger, Klaus, additional, Hansen, Ingo Arne, additional, Nash, Chris, additional, Fowkes, Tony, additional, Ciccarelli, Carlo, additional, Giuntini, Andrea, additional, Groote, Peter, additional, Dobruszkes, Frédéric, additional, Moyano, Amparo, additional, Monzón, Andrés, additional, López, Elena, additional, Profillidis, Vassilios A., additional, Baron, Nacima, additional, Crainic, Teodor Gabriel, additional, Monchambert, Guillaume, additional, Hörcher, Daniel, additional, Tirachini, Alejandro, additional, Coulombel, Nicolas, additional, Nikitinas, Vilius, additional, Miliauskaitė, Skaistė, additional, Campos, Javier, additional, Pyrgidis, Christos, additional, Dolianitis, Alexandros, additional, Sys, Christa, additional, Vanelslander, Thierry, additional, Ducruet, César, additional, Berli, Justin, additional, Psaraftis, Harilaos N., additional, Slack, Brian, additional, Haralambides, Hercules, additional, Trujillo, Lourdes, additional, Hidalgo, Daniel Castillo, additional, Herrera, Manuel, additional, Tovar, Beatriz, additional, Wall, Alan, additional, Woxenius, Johan, additional, Behdani, Behzad, additional, Wiegmans, Bart, additional, Fan, Yun, additional, Ferrari, Claudio, additional, Tei, Alessio, additional, Pallis, Athanasios A., additional, Papachristou, Aimilia A., additional, Fedi, Laurent, additional, Burton, Gareth C., additional, Miller, Mimosa T., additional, Stott, Paul William, additional, Abedin, Zain Ul, additional, Ceder, Avishai (Avi), additional, Hempsell, Mark, additional, Cotana, Franco, additional, Manni, Mattia, additional, Uteng, Priya, additional, Susilo, Yusak, additional, Budnitz, Hannah D, additional, Tranos, Emmanouil, additional, Chapman, Lee, additional, Mullen, Caroline, additional, Corman, Francesco, additional, Al-Sharif, Lutfi, additional, Mitra, Raktim, additional, Hess, Paul M., additional, Cohen, Adam, additional, Cheng, Long, additional, De Vos, Jonas, additional, and Witlox, Frank, additional

Published
2021
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20. A global view of T cell metabolism in systemic lupus erythematosus.

Author

Goetz, Andrew, Cagmat, Joy, Brusko, Maigan, Brusko, Todd M., Rushin, Anna, Merritt, Matthew, Garrett, Timothy, Morel, Laurence, and Dixit, Purushottam

Subjects
SYSTEMIC lupus erythematosus, T cells, CELL metabolism, CELL physiology
Abstract

Impaired metabolism is recognized as an important contributor to pathogenicity of T cells in Systemic Lupus Erythematosus (SLE). Over the last two decades, we have acquired significant knowledge about the signaling and transcriptomic programs related to metabolic rewiring in healthy and SLE T cells. However, our understanding of metabolic network activity derives largely from studying metabolic pathways in isolation. Here, we argue that enzymatic activities are necessarily coupled through mass and energy balance constraints with in-built network-wide dependencies and compensation mechanisms. Therefore, metabolic rewiring of T cells in SLE must be understood in the context of the entire network, including changes in metabolic demands such as shifts in biomass composition and cytokine secretion rates as well as changes in uptake/excretion rates of multiple nutrients and waste products. As a way forward, we suggest cell physiology experiments and integration of orthogonal metabolic measurements through computational modeling towards a comprehensive understanding of T cell metabolism in lupus. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Contributors

Author

Albalate, Daniel, primary, Budd, Thomas, additional, Decroly, Jean-Michel, additional, Dobruszkes, Frédéric, additional, Duval, David Timothy, additional, Fageda, Xavier, additional, Fichert, Frank, additional, Goetz, Andrew R., additional, Graham, Anne, additional, Halpern, Nigel, additional, Hanke, Michael, additional, Henderson, Isaac Levi, additional, Humphreys, Claire, additional, Martín, Juan Carlos, additional, Metz, David, additional, O’Connell, John F., additional, Ramos-Pérez, David, additional, Ryley, Tim, additional, Tsui, Wai Hong Kan, additional, Voltes-Dorta, Augusto, additional, and Wattanacharoensil, Walanchalee, additional

Published
2019
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29. New and Emerging Pathways for Transport Geography

Author

Dobruszkes, Frédéric, Chen, Chia-Lin, Cidell, Julie, Condeço-Melhorado, Ana, Goetz, Andrew, Ryley, Tim, Thévenin, Thomas, Dobruszkes, Frédéric, Chen, Chia-Lin, Cidell, Julie, Condeço-Melhorado, Ana, Goetz, Andrew, Ryley, Tim, and Thévenin, Thomas

Abstract

Transport geography has become more diverse in terms of research themes, methods, and sources considered. New pathways for transport research have been initiated not only within the field but also by scholars from other disciplines, for instance, sociology and environmental science. In addition, the advent of the big data era has offered new research opportunities while also raising new methodological concerns. These new directions have sometimes shaken up transport geographers and forced them to change their perspective. In this context, this chapter considers advances, opportunities, and, sometimes, risks and disappointments induced by the following topics to transport geography: epistemology and social theories; urban transport; long-distance travel and the environment; the relationships between transport and spatial planning; linking spaces, places, and time; new (big) data sources; and visualising transport geography., info:eu-repo/semantics/published

Published
2023

47. Shared-use rail corridors: a comparison of institutional perspectives in the United States and the European Union.

Author

Minn, Michael, Brady, Sylvia, Cidell, Julie, Ratner, Keith, and Goetz, Andrew

Subjects
RAILROAD freight service, GOVERNMENT ownership of railroads, RAILROAD management, CAPITAL investments, TIME perspective, BEST practices
Abstract

This paper reviews existing literature to identify issues, challenges, and best practices associated with shared-use freight and passenger rail corridors. Specifically, this paper will compare and contrast shared-corridor practices from an institutional perspective in the United States and the European Union. These two regions were chosen because of their shared social, political, technological, and economic ties, their historical mixes of private and state railroad operations, and because of the significant contemporary differences in the role of rail in these two regions. That mix of similarities and differences clarifies important commonalities specific to freight and passenger railroads that may be applicable in other times and places. Best practices include planning for: capital investment, long-term time horizons, measurable incremental improvements, regional multi-modality, and mutual benefits between freight and passenger operations. [ABSTRACT FROM AUTHOR]

Published
2022
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