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24 results on '"Goff, Arthur J."'

2. Smallpox lesion characterization in placebo-treated and tecovirimat-treated macaques using traditional and novel methods

Author

Bell, Todd M., primary, Facemire, Paul, additional, Bearss, Jeremy J., additional, Raymond, Jo Lynne, additional, Chapman, Jennifer, additional, Zeng, Xiankun, additional, Shamblin, Joshua D., additional, Williams, Janice A., additional, Grosenbach, Douglas W., additional, Hruby, Dennis E., additional, Damon, Inger K., additional, Goff, Arthur J., additional, and Mucker, Eric M., additional

Published
2024
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5. Evaluation of Virulence in Cynomolgus Macaques Using a Virus Preparation Enriched for the Extracellular Form of Monkeypox Virus

Author

Mucker, Eric M., primary, Shamblin, Josh D., additional, Goff, Arthur J., additional, Bell, Todd M., additional, Reed, Christopher, additional, Twenhafel, Nancy A., additional, Chapman, Jennifer, additional, Mattix, Marc, additional, Alves, Derron, additional, Garry, Robert F., additional, and Hensley, Lisa E., additional

Published
2022
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6. Asymmetric and non-stoichiometric glycoprotein recognition by two distinct antibodies results in broad protection against ebolaviruses

Author

Milligan, Jacob C., primary, Davis, Carl W., additional, Yu, Xiaoying, additional, Ilinykh, Philipp A., additional, Huang, Kai, additional, Halfmann, Peter J., additional, Cross, Robert W., additional, Borisevich, Viktoriya, additional, Agans, Krystle N., additional, Geisbert, Joan B., additional, Chennareddy, Chakravarthy, additional, Goff, Arthur J., additional, Piper, Ashley E., additional, Hui, Sean, additional, Shaffer, Kelly C.L., additional, Buck, Tierra, additional, Heinrich, Megan L., additional, Branco, Luis M., additional, Crozier, Ian, additional, Holbrook, Michael R., additional, Kuhn, Jens H., additional, Kawaoka, Yoshihiro, additional, Glass, Pamela J., additional, Bukreyev, Alexander, additional, Geisbert, Thomas W., additional, Worwa, Gabriella, additional, Ahmed, Rafi, additional, and Saphire, Erica Ollmann, additional

Published
2022
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8. Natural history of disease in cynomolgus monkeys exposed to Ebola virus Kikwit strain demonstrates the reliability of this non-human primate model for Ebola virus disease

Author

Niemuth, Nancy A., primary, Fallacara, Dawn, additional, Triplett, Cheryl A., additional, Tamrakar, Sanjay M., additional, Rajbhandari, Alisha, additional, Florence, Clint, additional, Ward, Lucy, additional, Griffiths, Anthony, additional, Carrion, Ricardo, additional, Goez-Gazi, Yenny, additional, Alfson, Kendra J., additional, Staples, Hilary M., additional, Brasel, Trevor, additional, Comer, Jason E., additional, Massey, Shane, additional, Smith, Jeanon, additional, Kocsis, Andrew, additional, Lowry, Jake, additional, Johnston, Sara C., additional, Nalca, Aysegul, additional, Goff, Arthur J., additional, Shurtleff, Amy C., additional, Pitt, Margaret L., additional, Trefry, John, additional, and Fay, Michael P., additional

Published
2021
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9. Asymmetric and Non-Stoichiometric Recognition Results in Broad Protection Against Ebolaviruses by a Two-Antibody Cocktail

Author

Milligan, Jacob C., primary, Davis, Carl W., additional, Yu, Saphire Lab/Xiaoying, additional, Ilinykh, Philipp A., additional, Huang, Kai, additional, Halfmann, Peter, additional, Cross, Robert W., additional, Borisevich, Viktoriya, additional, Agans, Krystle N., additional, Geisbert, Joan B., additional, Chennareddy, Chakravarthy, additional, Goff, Arthur J., additional, Piper, Ashley E., additional, Hui, Sean, additional, Shaffer, Kelly, additional, Buck, Tierra, additional, Heinrich, Megan L., additional, Branco, Luis M., additional, Crozier, Ian, additional, Holbrook, Michael R., additional, Kuhn, Jens H., additional, Kawaoka, Yoshihiro, additional, Glass, Pamela J., additional, Bukreyev, Alexander, additional, Geisbert, Thomas W., additional, Worwa, Gabriella, additional, Ahmed, Rafi, additional, and Saphire, Erica Ollmann, additional

Published
2021
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10. Longitudinal Analysis of the Human B Cell Response to Ebola Virus Infection

Author

Davis, Carl W., primary, Jackson, Katherine J.L., additional, McElroy, Anita K., additional, Halfmann, Peter, additional, Huang, Jessica, additional, Chennareddy, Chakravarthy, additional, Piper, Ashley E., additional, Leung, Yvonne, additional, Albariño, César G., additional, Crozier, Ian, additional, Ellebedy, Ali H., additional, Sidney, John, additional, Sette, Alessandro, additional, Yu, Tianwei, additional, Nielsen, Sandra C.A., additional, Goff, Arthur J., additional, Spiropoulou, Christina F., additional, Saphire, Erica Ollman, additional, Cavet, Guy, additional, Kawaoka, Yoshihiro, additional, Mehta, Aneesh K., additional, Glass, Pamela J., additional, Boyd, Scott D., additional, and Ahmed, Rafi, additional

Published
2019
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11. Virus-encoded miRNAs in Ebola virus disease

Author

Duy, Janice, primary, Honko, Anna N., additional, Altamura, Louis A., additional, Bixler, Sandra L., additional, Wollen-Roberts, Suzanne, additional, Wauquier, Nadia, additional, O’Hearn, Aileen, additional, Mucker, Eric M., additional, Johnson, Joshua C., additional, Shamblin, Joshua D., additional, Zelko, Justine, additional, Botto, Miriam A., additional, Bangura, James, additional, Coomber, Moinya, additional, Pitt, M. Louise, additional, Gonzalez, Jean-Paul, additional, Schoepp, Randal J., additional, Goff, Arthur J., additional, and Minogue, Timothy D., additional

Published
2018
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12. A conserved transcriptional response to intranasal Ebola virus exposure in nonhuman primates prior to onset of fever

Author

Speranza, Emily, primary, Bixler, Sandra L., additional, Altamura, Louis A., additional, Arnold, Catherine E., additional, Pratt, William D., additional, Taylor-Howell, Cheryl, additional, Burrows, Christina, additional, Aguilar, William, additional, Rossi, Franco, additional, Shamblin, Joshua D., additional, Wollen, Suzanne E., additional, Zelko, Justine M., additional, Minogue, Timothy, additional, Nagle, Elyse, additional, Palacios, Gustavo, additional, Goff, Arthur J., additional, and Connor, John H., additional

Published
2018
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14. Comparison of Transcriptomic Platforms for Analysis of Whole Blood from Ebola-Infected Cynomolgus Macaques

Author

Speranza, Emily, primary, Altamura, Louis A., additional, Kulcsar, Kirsten, additional, Bixler, Sandra L., additional, Rossi, Cynthia A., additional, Schoepp, Randal J., additional, Nagle, Elyse, additional, Aguilar, William, additional, Douglas, Christina E., additional, Delp, Korey L., additional, Minogue, Timothy D., additional, Palacios, Gustavo, additional, Goff, Arthur J., additional, and Connor, John H., additional

Published
2017
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15. Temporal Characterization of Marburg Virus Angola Infection following Aerosol Challenge in Rhesus Macaques

Author

Lin, Kenny L., primary, Twenhafel, Nancy A., additional, Connor, John H., additional, Cashman, Kathleen A., additional, Shamblin, Joshua D., additional, Donnelly, Ginger C., additional, Esham, Heather L., additional, Wlazlowski, Carly B., additional, Johnson, Joshua C., additional, Honko, Anna N., additional, Botto, Miriam A., additional, Yen, Judy, additional, Hensley, Lisa E., additional, and Goff, Arthur J., additional

Published
2015
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19. Efficacy of Tecovirimat (ST-246) in Nonhuman Primates Infected with Variola Virus (Smallpox)

Author

Mucker, Eric M., primary, Goff, Arthur J., additional, Shamblin, Joshua D., additional, Grosenbach, Douglas W., additional, Damon, Inger K., additional, Mehal, Jason M., additional, Holman, Robert C., additional, Carroll, Darin, additional, Gallardo, Nadia, additional, Olson, Victoria A., additional, Clemmons, Cody J., additional, Hudson, Paul, additional, and Hruby, Dennis E., additional

Published
2013
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20. The Role of Cytokines and Chemokines in Filovirus Infection.

Author

Bixler, Sandra L. and Goff, Arthur J.

Subjects
*CYTOKINES, *CHEMOKINES, *FILOVIRIDAE, *MARBURG virus, *IMMUNOPATHOLOGY, TREATMENT of Ebola virus diseases
Abstract

Ebola- and marburgviruses are highly pathogenic filoviruses and causative agents of viral hemorrhagic fever. Filovirus disease is characterized by a dysregulated immune response, severe organ damage, and coagulation abnormalities. This includes modulation of cytokines, signaling mediators that regulate various components of the immune system as well as other biological processes. Here we examine the role of cytokines in filovirus infection, with an emphasis on understanding how these molecules affect development of the antiviral immune response and influence pathology. These proteins may present targets for immune modulation by therapeutic agents and vaccines in an effort to boost the natural immune response to infection and/or reduce immunopathology. [ABSTRACT FROM AUTHOR]

Published
2015
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23. Virulence of Marburg Virus Angola Compared to Mt. Elgon (Musoke) in Macaques: A Pooled Survival Analysis.

Author

Blair, Paul W., Keshtkar-Jahromi, Maryam, Psoter, Kevin J., Reisler, Ronald B., Warren, Travis K., Johnston, Sara C., Goff, Arthur J., Downey, Lydia G., Bavari, Sina, and Cardile, Anthony P.

Subjects
MARBURG virus, FILOVIRIDAE, VIREMIA, MACAQUES, ANIMAL models in research
Abstract

Angola variant (MARV/Ang) has replaced Mt. Elgon variant Musoke isolate (MARV/MtE-Mus) as the consensus standard variant for Marburg virus research and is regarded as causing a more aggressive phenotype of disease in animal models; however, there is a dearth of published evidence supporting the higher virulence of MARV/Ang. In this retrospective study, we used data pooled from eight separate studies in nonhuman primates experimentally exposed with either 1000 pfu intramuscular (IM) MARV/Ang or MARV/MtE-Mus between 2012 and 2017 at the United States Army Medical Research Institute of Infectious Diseases (USAMRIID). Multivariable Cox proportional hazards regression was used to evaluate the association of variant type with time to death, the development of anorexia, rash, viremia, and 10 select clinical laboratory values. A total of 47 cynomolgus monkeys were included, of which 18 were exposed to MARV/Ang in three separate studies and 29 to MARV/MtE-Mus in five studies. Following universally fatal Marburg virus exposure, compared to MARV/MtE-Mus, MARV/Ang was associated with an increased risk of death (HR = 22.10; 95% CI: 7.08, 68.93), rash (HR = 5.87; 95% CI: 2.76, 12.51) and loss of appetite (HR = 35.10; 95% CI: 7.60, 162.18). Our data demonstrate an increased virulence of MARV/Ang compared to MARV/MtE-Mus variant in the 1000 pfu IM cynomolgus macaque model. [ABSTRACT FROM AUTHOR]

Published
2018
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24. Natural History of Aerosol Exposure with Marburg Virus in Rhesus Macaques.

Author

Ewers EC, Pratt WD, Twenhafel NA, Shamblin J, Donnelly G, Esham H, Wlazlowski C, Johnson JC, Botto M, Hensley LE, and Goff AJ

Subjects
Animals, Blood Cell Count, Blood Coagulation Tests, Cytokines blood, Female, Kidney Function Tests, Liver Function Tests, Male, Marburg Virus Disease diagnosis, Viremia, Macaca mulatta virology, Marburg Virus Disease transmission, Marburg Virus Disease virology, Marburgvirus physiology
Abstract

Marburg virus causes severe and often lethal viral disease in humans, and there are currently no Food and Drug Administration (FDA) approved medical countermeasures. The sporadic occurrence of Marburg outbreaks does not allow for evaluation of countermeasures in humans, so therapeutic and vaccine candidates can only be approved through the FDA animal rule-a mechanism requiring well-characterized animal models in which efficacy would be evaluated. Here, we describe a natural history study where rhesus macaques were surgically implanted with telemetry devices and central venous catheters prior to aerosol exposure with Marburg-Angola virus, enabling continuous physiologic monitoring and blood sampling without anesthesia. After a three to four day incubation period, all animals developed fever, viremia, and lymphopenia before developing tachycardia, tachypnea, elevated liver enzymes, decreased liver function, azotemia, elevated D-dimer levels and elevated pro-inflammatory cytokines suggesting a systemic inflammatory response with organ failure. The final, terminal period began with the onset of sustained hypotension, dehydration progressed with signs of major organ hypoperfusion (hyperlactatemia, acute kidney injury, hypothermia), and ended with euthanasia or death. The most significant pathologic findings were marked infection of the respiratory lymphoid tissue with destruction of the tracheobronchial and mediastinal lymph nodes, and severe diffuse infection in the liver, and splenitis.

Published
2016
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