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1,590 results on '"Goffeau A"'

1. Combined phylogeny and neighborhood analysis of the evolution of the ABC transporters conferring multiple drug resistance in hemiascomycete yeasts

Author

Goffeau André, Diffels Julie F, Seret Marie-Line, and Baret Philippe V

Subjects
Biotechnology, TP248.13-248.65, Genetics, QH426-470
Abstract

Abstract Background Pleiotropic Drug Resistant transporters (PDR) are members of the ATP-Binding Cassette (ABC) subfamily which export antifungals and other xenobiotics in fungi and plants. This subfamily of transmembrane transporters has nine known members in Saccharomyces cerevisiae. We have analyzed the complex evolution of the pleiotropic drug resistance proteins (Pdrp) subfamily where gene duplications and deletions occur independently in individual genomes. This study was carried out on 62 Pdrp from nine hemiascomycetous species, seven of which span 6 of the 14 clades of the Saccharomyces complex while the two others species, Debaryomyces hansenii and Yarrowia lipolytica, are further apart from an evolutive point of view. Results Combined phylogenetic and neighborhood analyses enabled us to identify five Pdrp clusters in the Saccharomyces complex. Three of them comprise orthologs of the Pdrp sensu stricto, Pdr5p, Pdr10p, Pdr12p, Pdr15p, Snq2p and YNR070wp. The evolutive pathway of the orthologs of Snq2 and YNR070w is particularly complex due to a tandem gene array in Eremothecium gossypii, Kluyveromyces lactis and Saccharomyces (Lachancea) kluyveri. This pathway and different cases of duplications and deletions were clarified by using a neighborhood analysis based on synteny. For the two distant species, Yarrowia lipolytica and Debaryomyces hansenii, no neighborhood evidence is available for these clusters and many homologs of Pdr5 and Pdr15 are phylogenetically assigned to species-based clusters. Two other clusters comprise the orthologs of the sensu lato Pdrp, Aus1p/Pdr11p and YOL075cp respectively. The evolutionary pathway of these clusters is simpler. Nevertheless, orthologs of these genes are missing in some species. Conclusion Numerous duplications were traced among the Hemiascomycetous Pdrp studied. The role of the Whole Genome Duplication (WGD) is sorted out and our analyses confirm the common ancestrality of Pdr5p and Pdr15p. A tandem gene array is observed in Eremothecium gossypii. One of the copies is the ortholog of Snq2 while the other one is lost in the post-WGD species. The neighborhood analysis provides an efficient method to trace the history of genes and disentangle the orthology and paralogy relationships.

Published
2009
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2. The Genome of the Kinetoplastid Parasite, Leishmania major

Author

Ivens, Alasdair C., Peacock, Christopher S., Worthey, Elizabeth A., Murphy, Lee, Aggarwal, Gautam, Berriman, Matthew, Sisk, Ellen, Rajandream, Marie-Adele, Adlem, Ellen, Aert, Rita, Anupama, Atashi, Apostolou, Zina, Attipoe, Philip, Bason, Nathalie, Bauser, Christopher, Beck, Alfred, Beverley, Stephen M., Bianchettin, Gabriella, Borzym, Katja, Bothe, Gordana, Bruschi, Carlo V., Collins, Matt, Cadag, Eithon, Ciarloni, Laura, Clayton, Christine, Cronin, Ann, Cruz, Angela K., Davies, Robert M., De Gaudenzi, Javier, Dobson, Deborah E., Duesterhoeft, Andreas, Fazelina, Gholam, Fosker, Nigel, Frasch, Alberto Carlos, Fraser, Audrey, Fuchs, Monika, Gabel, Claudia, Goble, Arlette, Goffeau, André, Harris, David, Hertz-Fowler, Christiane, Hilbert, Helmut, Horn, David, Huang, Yiting, Klages, Sven, Knights, Andrew, Kube, Michael, Larke, Natasha, Litvin, Lyudmila, Lord, Angela, Louie, Tin, Marra, Marco, Masuy, David, Matthews, Keith, Michaeli, Shulamit, Mottram, Jeremy C., Müller-Auer, Silke, Munden, Heather, Nelson, Siri, Norbertczak, Halina, Oliver, Karen, O'Neil, Susan, Pentony, Martin, Pohl, Thomas M., Price, Claire, Purnelle, Bénédicte, Quail, Michael A., Rabbinowitsch, Ester, Reinhardt, Richard, Rieger, Michael, Rinta, Joel, Robben, Johan, Robertson, Laura, Ruiz, Jeronimo C., Rutter, Simon, Saunders, David, Schäfer, Melanie, Schein, Jacquie, Schwartz, David C., Seeger, Kathy, Seyler, Amber, Sharp, Sarah, Shin, Heesun, Sivam, Dhileep, Squares, Rob, Squares, Steve, Tosato, Valentina, Vogt, Christy, Volckaert, Guido, Wambutt, Rolf, Warren, Tim, Wedler, Holger, Woodward, John, Zhou, Shiguo, Zimmermann, Wolfgang, Smith, Deborah F., Blackwell, Jenefer M., Stuart, Kenneth D., Barrell, Bart, and Myler, Peter J.

Published
2005

3. Analysis of the Chromosome Sequence of the Legume Symbiont Sinorhizobium meliloti Strain 1021

Author

Capela, Delphine, Barloy-Hubler, Frédérique, Gouzy, Jérôme, Bothe, Gordana, Ampe, Frédéric, Batut, Jacques, Boistard, Pierre, Becker, Anke, Boutry, Marc, Cadieu, Edouard, Dréano, Stéphane, Gloux, Stéphanie, Godrie, Thérèse, Goffeau, André, Kahn, Daniel, Kiss, Ernö, Lelaure, Valérie, Masuy, David, Pohl, Thomas, Portetelle, Daniel, Pühler, Alfred, Purnelle, Bénédicte, Ramsperger, Ulf, Renard, Clotilde, Thébault, Patricia, Vandenbol, Micheline, Weidner, Stefan, and Galibert, Francis

Published
2001

4. The Composite Genome of the Legume Symbiont Sinorhizobium meliloti

Author

Galibert, Francis, Finan, Turlough M., Long, Sharon R., Pühler, Alfred, Abola, Pia, Ampe, Frédéric, Barloy-Hubler, Frédérique, Barnett, Melanie J., Becker, Anke, Boistard, Pierre, Bothe, Gordana, Boutry, Marc, Bowser, Leah, Buhrmester, Jens, Cadieu, Edouard, Capela, Delphine, Chain, Patrick, Cowie, Alison, Davis, Ronald W., Dréano, Stéphane, Federspiel, Nancy A., Fisher, Robert F., Gloux, Stéphanie, Godrie, Thérèse, Goffeau, André, Golding, Brian, Gouzy, Jérôme, Gurjal, Mani, Hernandez-Lucas, Ismael, Hong, Andrea, Huizar, Lucas, Hyman, Richard W., Jones, Ted, Kahn, Daniel, Kahn, Michael L., Kalman, Sue, Keating, David H., Kiss, Ernö, Komp, Caridad, Lelaure, Valérie, Masuy, David, Palm, Curtis, Peck, Melicent C., Pohl, Thomas M, Portetelle, Daniel, Purnelle, Bénédicte, Ramsperger, Uwe, Surzycki, Raymond, Thébault, Patricia, Vandenbol, Micheline, Weidner, Stefan, Wells, Derek H., Wong, Kim, Yeh, Kuo-Chen, and Batut, Jacques

Published
2001

5. Life with 6000 Genes

Author

Goffeau, A., Barrell, B. G., Bussey, H., Davis, R. W., Dujon, B., Feldmann, H., Galibert, F., Hoheisel, J. D., Jacq, C., Johnston, M., Louis, E. J., Mewes, H. W., Murakami, Y., Philippsen, P., Tettelin, H., and Oliver, S. G.

Published
1996

14. Emergence of species-specific transporters during evolution of the Hemiascomycete phylum

Author

De Hertogh, Benoit, Hancy, Frederic, Goffeau, Andre, and Baret, Philippe V.

Subjects
Biological sciences
Abstract

We have traced the evolution patterns of 2480 transmembrane transporters from five complete genome sequences spanning the entire Hemiascomycete phylum: Saccharomyces cerevisiae, Candida glabrata, Kluyveromyces lactis, Debaryomyces hansenii, and Yarrowia lipolytica. The use of nonambiguous functional and phylogenetic criteria derived from the TCDB classification system has allowed the identification within the Hemiascomycete phylum of 97 small phylogenetic transporter subfamilies comprising a total of 355 transporters submitted to four distinct evolution patterns named 'ubiquitous,' 'species specific,' 'phylum gains and losses,' or 'homoplasic.' This analysis identifies the transporters that contribute to the emergence of species during the evolution of the Hemiascomycete phylum and may aid in establishing novel phylogenetic criteria for species classification.

Published
2006

15. Complete sequence and comparative genome analysis of the dairy bacterium Streptococcus thermophilus

Author

Bolotin, Alexander, Quinquis, Benoît, Renault, Pierre, Sorokin, Alexei, Ehrlich, S Dusko, Kulakauskas, Saulius, Lapidus, Alla, Goltsman, Eugene, Mazur, Michael, Pusch, Gordon D, Fonstein, Michael, Overbeek, Ross, Kyprides, Nikos, Purnelle, Bénédicte, Prozzi, Deborah, Ngui, Katrina, Masuy, David, Hancy, Frédéric, Burteau, Sophie, Boutry, Marc, Delcour, Jean, Goffeau, André, and Hols, Pascal

Published
2004
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27. The genome sequence of Schizosaccharomyces pombe

Author

Wood, V., Gwilliam, R., Rajandream, M.-A., Lyne, M., Lyne, R., Stewart, A., Sgouros, J., Peat, N., Hayles, J., Baker, S., Basham, D., Bowman, S., Brooks, K., Brown, D., Brown, S., Chillingworth, T., Churcher, C., Collins, M., Connor, R., Cronin, A., Davis, P., Feltwell, T., Fraser, A., Gentles, S., Goble, A., Hamlin, N., Harris, D., Hidalgo, J., Hodgson, G., Holroyd, S., Hornsby, T., Howarth, S., Huckle, E. J., Hunt, S., Jagels, K., James, K., Jones, L., Jones, M., Leather, S., McDonald, S., McLean, J., Mooney, P., Moule, S., Mungall, K., Murphy, L., Niblett, D., Odell, C., Oliver, K., O'Neil, S., Pearson, D., Quail, M. A., Rabbinowitsch, E., Rutherford, K., Rutter, S., Saunders, D., Seeger, K., Sharp, S., Skelton, J., Simmonds, M., Squares, R., Squares, S., Stevens, K., Taylor, K., Taylor, R. G., Tivey, A., Walsh, S., Warren, T., Whitehead, S., Woodward, J., Volckaert, G., Aert, R., Robben, J., Grymonprez, B., Weltjens, I., Vanstreels, E., Rieger, M., Schafer, M., Muller-Auer, S., Gabel, C., Fuchs, M., Fritzc, C., Holzer, E., Moestl, D., Hilbert, H., Borzym, K., Langer, I., Beck, A., Lehrach, H., Reinhardt, R., Pohl, T. M., Eger, P., Zimmermann, W., Wedler, H., Wambutt, R., Purnelle, B., Goffeau, A., Cadieu, E., Dreano, S., Gloux, S., Lelaure, V., Mottier, S., Galibert, F., Aves, S. J., Xiang, Z., Hunt, C., Moore, K., Hurst, S. M., Lucas, M., Rochet, M., Gaillardin, C., Tallada, V. A., Garzon, A., Thode, G., Daga, R. R., Cruzado, L., Jimenez, J., Sanchez, M., del Rey, F., Benito, J., Dominguez, A., Revuelta, J. L., Moreno, S., Armstrong, J., Forsburg, S. L., Cerrutti, L., Lowe, T., McCombie, W. R., Paulsen, I., Potashkin, J., Shpakovski, G. V., Ussery, D., Barrell, B. G., and Nurse, P.

Abstract

Author(s): V. Wood [1]; R. Gwilliam [1]; M.-A. Rajandream (corresponding author) [1]; M. Lyne [1]; R. Lyne [1]; A. Stewart [2]; J. Sgouros [2]; N. Peat [3]; J. Hayles [3]; [...]

Published
2002
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28. Protein kinase C effectors bind to multidrug ABC transporters and inhibit their activity

Author

Conseil, Gwenaelle, Perez-Victoria, Jose Maria, Jault, Jean-Michel, Gamarro, Francisco, Goffeau, Andre, Hofmann, Johann, and Di Pietro, Attilio

Subjects
Glycoproteins -- Research, Biological transport, Active -- Research, Enzyme inhibitors -- Research, Protein kinases -- Research, Biological sciences, Chemistry
Abstract

Inhibitors of protein kinase C can bind directly to P-glycoprotein and other multidrug transporters. It was previously thought that the inhibitors simply prevented PKC-mediated phosphorylation of P-glycoprotein.

Published
2001

30. Prenyl-flavonoids as potent inhibitors of the Pdr5p multidrug ABC transporter from Saccharomyces cerevisiae

Author

Conseil, Gwenaelle, Decottignies, Anabelle, Jault, Jean-Michael, Comte, Gilles, Barron, Denis, Goffeau, Andre, and Di Peitro, Attilio

Subjects
Biochemistry -- Research, Brewer's yeast -- Analysis, Flavonoids -- Research, Gene expression -- Research, Adenosine triphosphate -- Analysis, Plasma membranes -- Analysis, Biological sciences, Chemistry
Abstract

Research has been conducted on the Pdr5p multidrug ABC ('ATP-binding cassette') transporter. The overexpression of the transporter in the yeast plasma membranes to exhibit gene disruption is discussed.

Published
2000

33. ABC Transporters

Author

Goffeau, André, primary, De Hertogh, Benoît, additional, and Baret, Philippe V., additional

Published
2004
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39. The complete genome sequence of the Gram-positive bacterium Bacillus subtilis

Author

Kunst, F., Ogasawara, N., Moszer, I., Albertini, A.M., Alloni, G., Azevedo, V., Bertero, M.G., Bessieres, P., Bolotin, A., Borchert, S., Borriss, R., Boursier, L., Brans, A., Braun, M., Brignell, S.C., Bron, S., Brouillet, S., Bruschi, C.V., Caldwell, B., Capuano, V., Carter, N.M., Choi, S.-K, Codani, J.-J., Connerton, I.F., Cummings, N.J., Daniel, R.A., Denizot, F., Devine, K.M., Dusterhoft, A., Ehrlich, S.D., Emmerson, P.T., Entian, K.D., Errington, J., Fabret, C., Ferrari, E., Foulger, D., Fritz, C., Fujita, M., Fujita, Y., Fuma, S., Galizzi, A., Galleron, N.Ghim, S.-Y., Glaser, P., Goffeau, A., Golightly, E.J., Grandi, G., Guiseppi, G., Guy, B.J., and Haga, K.

Subjects
Bacillus subtilis -- Genetic aspects, Nucleotide sequence -- Research, Evolution -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

The complete genome sequence of the Gram-positive bacterium Bacillus subtilis consists of 4,214,810 base pairs and 4,100 protein-coding genes. The genetic sequence is illustrated, together with a distribution of A and T-rich islands and coding nucleotides. Much of the dinucleotide bias has been observed in previous prokaryote research. Further research into the evolutionary development of gram-positive and gram-negative bacteria is possible.

Published
1997

41. Amino acid replacements at seven different histidines in the yeast plasma membrane H+-ATPase reveal critical positions at His285 and His701

Author

Wach, Achim, Supply, Philip, Dufour, Jean-Pierre, and Goffeau, Andre

Subjects
Histidine -- Research, Plasma membranes -- Research, Adenosine triphosphatase -- Research, Saccharomyces -- Research, Biological sciences, Chemistry
Abstract

The histidine residues in the plasma membrane H+-ATPase (Pma1) of the yeast Saccharomyces cerevisiae that are involved in membrane activity were identified by combining systematic site-directed mutagenesis and kinetic analysis. Only substitutions at H701 with the amino acids Asp, Gln and Arg produced a lethal effect, indicating that H701 is involved in H+-ATPase activity. Mutations at H285Q and H285R had no effect on the cells in normal growth conditions, but growth of H285Q was sensitive to acid pH. Both also exhibited optimal ATPase-specific activity and other kinetic parameters at a substrate concentration much lower than the maximum enzyme concentration. It is suggested that H285Q is involved in the transition step of the ATP hydrolysis catalytic cycle.

Published
1996

47. Glutathione may have implications in the design of 3-bromopyruvate treatment protocols for both fungal and algal infections as well as multiple myeloma

Author

Magdalena Cal-Bąkowska, Peter L. Pedersen, Daria Augustyniak, André Goffeau, Katarzyna Niedźwiecka, Mariusz Dyląg, Young Hee Ko, Stanisław Ułaszewski, and Grazyna Majkowska-Skrobek

Subjects
0301 basic medicine, Biology, Prototheca, Infections, buthionine sulfoximine, 03 medical and health sciences, chemistry.chemical_compound, Minimum inhibitory concentration, medicine, Humans, Buthionine sulfoximine, Enzyme Inhibitors, Pyruvates, Pathogen, Multiple myeloma, Cells, Cultured, Cryptococcus neoformans, chemistry.chemical_classification, Glutathione, medicine.disease, biology.organism_classification, Molecular biology, 030104 developmental biology, Enzyme, Oncology, chemistry, MM cells, Mycoses, Research Design, Immunology, genes expression, fungi, Multiple Myeloma, 3-bromopyruvate (3BP), Intracellular, Research Paper
Abstract

// Katarzyna Niedźwiecka 1 , Mariusz Dyląg 1, * , Daria Augustyniak 2 , Grazyna Majkowska-Skrobek 2 , Magdalena Cal-Bąkowska 1 , Young H. Ko 3 , Peter L. Pedersen 4 , Andre Goffeau 5 , Stanislaw Ulaszewski 1, * 1 Department of Genetics,Institute of Genetics and Microbiology, University of Wroclaw, Wroclaw, Poland 2 Department of Pathogen Biology and Immunology, Institute of Genetics and Microbiology, University of Wroclaw, Wroclaw, Poland 3 KoDiscovery, LLC, UM BioPark, Baltimore, MD, USA 4 Departments of Biological Chemistry and Oncology and Sidney Kimmel Comprehensive Cancer Center (member at large), Johns Hopkins University School of Medicine, Baltimore, MD, USA 5 Institut des Sciences de la Vie, Universite Catholique de Louvain, Louvain-la-Neuve, Belgium * These authors have contributed equally to this work Correspondence to: Mariusz Dyląg, email: mariusz.dylag@uwr.edu.pl Stanislaw Ulaszewski, email: stanislaw.ulaszewski@uwr.edu.pl Keywords: 3-bromopyruvate (3BP), glutathione, buthionine sulfoximine, genes expression, fungi and MM cells Received: January 05, 2016 Accepted: August 13, 2016 Published: August 25, 2016 ABSTRACT In different fungal and algal species, the intracellular concentration of reduced glutathione (GSH) correlates closely with their susceptibility to killing by the small molecule alkylating agent 3-bromopyruvate (3BP). Additionally, in the case of Cryptococcus neoformans cells 3BP exhibits a synergistic effect with buthionine sulfoximine (BSO), a known GSH depletion agent. This effect was observed when 3BP and BSO were used together at concentrations respectively of 4-5 and almost 8 times lower than their Minimal Inhibitory Concentration (MIC). Finally, at different concentrations of 3BP (equal to the half-MIC, MIC and double-MIC in a case of fungi, 1 mM and 2.5 mM for microalgae and 25, 50, 100 μM for human multiple myeloma (MM) cells), a significant decrease in GSH concentration is observed inside microorganisms as well as tumor cells. In contrast to the GSH concentration decrease, the presence of 3BP at concentrations corresponding to sub-MIC values or half maximal inhibitory concentration (IC 50 ) clearly results in increasing the expression of genes encoding enzymes involved in the synthesis of GSH in Cryptococcus neoformans and MM cells. Moreover, as shown for the first time in the MM cell model, the drastic decrease in the ATP level and GSH concentration and the increase in the amount of ROS caused by 3BP ultimately results in cell death.

Published
2016

48. The complete DNA sequence of yeast chromosome III

Author

Oliver, S.G., van der Aart, Q.J.M., Agostoni-Carbone, M.L., Aigle, M., Alberghina, L., Alexandraki, D., Antoine, G., Anwar, R., Ballesta, J.P.G., Benit, P., Berben, G., Bergantino, E., Biteau, N., Bolle, P.A., Bolotin-Fukuhara, M., Brown, A., Brown, A.J.P., Buhler, J.M., Carcano, C., Carignani, G., Cederberg, H., Chanet, R., Contreras, R., Crouzet, M., Daignan-Fornier, B., Defoor, E., Delgado, M., Demolder, J., Doira, C., Dubois, E., Dujon, B., Dusterhoft, A., Erdmann, D., Esteban, M., Fabre, F., Fairhead, C., Faye, G., Feldmann, H., Fiers, W., Francingues-Gaillard, M.C., Franco, L., Frontali, L., Fukuhara, H., Fuller, L.J., Galland, P., Gent, M.E., Gigot, D., Gilliquet, V., Glansdorff, N., Goffeau, A., Grenson, M., Grisanti, P., Grivell, L.A., de Haan, M., Haasemann, M., Hatat, D., Hoenicka, J., Hegemann, J., Herbert, C.J., Hilger, F., Hohmann, S., Hollenberg, C.P., Huse, K., Iborra, F., Indge, K.J., Isono, K., Jacq, C., Jacquet, M., James, C.M., Jauniaux, J.C., Jia, Y., Jimenez, A., Kelly, A., Kleinhans, U., Kreisl, P., Lanfranchi, G., Lewis, C., van der Linden, C.G., Lucchini, G., Lutzenkirchen, K., Maat, M.J., Mallet, L., Mannhaupt, G., Martegani, E., Mathieu, A., Maurer, C.T.C., McConnell, D., McKee, R.A., Messenguy, F., Mewes, H.W., Molemans, F., Montague, M.A., Muzi Falconi, M., Navas, L., Newlon, C.S., Noone, D., Pallier, C., Panzeri, L., Pearson, B.M., Perea, J., Philippsen, P., Pierard, A., Planta, R.J., Plevani, P., Poetsch, B., Pohl, F., Purnelle, B., Ramezani Rad, M., Rasmussen, S.W., Raynal, A., Remacha, M., Richterich, P., Roberts, A.B., Rodriguez, F., Sanz, E., Schaaff-Gerstenschlager, I., Scherens, B., Schweitzer, B., Shu, Y., Skala, J., Slonimski, P.P., Sor, F., Soustelle, C., Spiegelberg, R., Stateva, L.I., Steensma, H.Y., Steiner, S., Thierry, A., Thireos, G., Tzermia, M., Urrestarazu, L.A., Valle, G., Vetter, I., van Vliet-Reedijk, J.C., Voet, M., Volckaert, G., Vreken, P., Wang, H., Warmington, J.R., von Wettstein, D., Wicksteed, B.L., Wilson, C., Wurst, H., Xu, G., Yoshikawa, A., Zimmermann, F.K., and Sgouros, J.G.

Subjects
Saccharomyces -- Genetic aspects, Nucleotide sequence -- Research, Plant chromosomes -- Research, Genomes -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation
Published
1992

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