Search

Your search keyword '"Goldstein Ferber, Sari"' showing total 14 results
Start Over Author "Goldstein Ferber, Sari"
14 results on '"Goldstein Ferber, Sari"'

1. International study of the Complex Stress Reaction Syndrome: Implications for transdiagnostic clinical practice

Author

Goldstein Ferber, Sari, primary, Weller, Aron, additional, Hayes, Adele M, additional, Vannorsdall, Tracy D, additional, Ajlouni, Yaroup, additional, Qudah, Mo'nes, additional, Zalsman, Gil, additional, Shoval, Gal, additional, Jannini, Tommaso Benedetto, additional, Fiedler, Racquel, additional, Chen, Lily X, additional, Shayani, Danielle R, additional, Kachuki Dory, Elin, additional, Stolowicz-Melman, Dana, additional, Evans, Connor, additional, Trow, Megan, additional, Di Lorenzo, Giorgio, additional, and Rossi, Rodolfo, additional

Published
2023
Full Text
View/download PDF

11. Early life stress and development of the endocannabinoid system: A bidirectional process in programming future coping.

Author

Goldstein Ferber, Sari, Trezza, Viviana, and Weller, Aron

Abstract

The endocannabinoid system (ECS) critically regulates stress responsivity and emotional behavior throughout development. It regulates anxiety‐like behaviors in humans and animal models. In addition, it is sensitive to early life stress at the gene expression level in a sex‐dependent and region‐dependent manner, and these changes are already evident in the adolescent brain. The ECS modulates the neuroendocrine and behavioral effects of stress, and is also capable of being affected by stress exposure itself. Early life stress interferes with the development of corticolimbic circuits, a major location of endocannabinoid receptors, and increases vulnerability to adult psychopathology. Early life stress alters the ontogeny of the ECS, resulting in a sustained deficit in its function, particularly within the hippocampus. Specifically, exposure to early stress results in bidirectional changes in anandamide and 2‐AG tissue levels within the amygdala and hippocampus and reduces hippocampal endocannabinoid function at puberty. CB1 receptor densities across all brain regions are downregulated later in life following exposure to early life stress. Manipulations affecting the glucocorticoid and the endocannabinoid systems persistently adjust individual emotional responses and synaptic plasticity. This review aims to show the bidirectional trajectories of endocannabinoid modulation of emotionality in reaction to early life stress. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

14. Transdiagnostic considerations of mental health for the post-COVID era: Lessons from the first surge of the pandemic

Author

Sari Goldstein Ferber, Gal Shoval, Rodolfo Rossi, Viviana Trezza, Giorgio Di Lorenzo, Gil Zalsman, Aron Weller, J John Mann, Goldstein Ferber, Sari, Shoval, Gal, Rossi, Rodolfo, Trezza, Viviana, Di Lorenzo, Giorgio, Zalsman, Gil, Weller, Aron, and Mann, J John

Subjects
Mental disorder, Stre, Post-COVID-19, General Medicine, Reactive psychiatric disorder, Transdiagnosis, Diagnosi
Abstract

Background: The Coronavirus disease 19 (COVID-19)-related psychiatric burden partly results from prolonged social stress world-wide. Studies have examined the psychiatric impact of COVID-19 on Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM 5) and International Classification of Diseases 11th Revision (ICD-11) categories, implicating multiple diagnoses, complicating clinical management. Aim: To verify whether COVID-19-related psychopathology spans multiple DSM-5 and ICD-11 diagnoses, but not in a random pattern. Consequently, empirical analysis of the multiple associated symptoms will better describe COVID-19-related psychopathology. Methods: We conducted a bi-national study during the first surge of the pandemic: an Italian sample (n = 21217, studied March-April 2020); and three representative longitudinal samples from Israel (n = 1276, 1189, and 1432 respectively, studied May-July 2020). Data in Italy were collected by a national internet-based survey with an initially approached sample of about one million persons and in Israel by the Israeli Central Bureau of Statistics using probability-based national representative sampling. Data analysis focused on the frequency and patterns of reported multiple mental health symptoms. Results: Combinations with all symptoms were more prevalent than combinations with fewer symptoms, with no majorities-minorities differences in both countries, demonstrating the generalizability of the transdiagnostic pattern of mental health issues in both nations. A history of previous mental disorder (Italian study) and an increase in symptom prevalence over time (Israel study) were associated with an increased number of symptoms. Conclusions: Based on finding correlated symptom diversity spanning conventional diagnostic categories, we suggest that the pattern of mental health issues associated with the COVID-19 pandemic is transdiagnostic. Conclusion: The findings have implications for improving prevention and treatment of COVID-19 related psychopathology and for post-pandemic times in conditions resulting from multiplicity of stressors with mixed symptomatology in the clinical picture.

Published
2023

Catalog

Books, media, physical & digital resources
See catalog results