1,048 results on '"Golebiewska, A"'
Search Results
2. Deep intravital brain tumor imaging enabled by tailored three-photon microscopy and analysis
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Marc Cicero Schubert, Stella Judith Soyka, Amr Tamimi, Emanuel Maus, Julian Schroers, Niklas Wißmann, Ekin Reyhan, Svenja Kristin Tetzlaff, Yvonne Yang, Robert Denninger, Robin Peretzke, Carlo Beretta, Michael Drumm, Alina Heuer, Verena Buchert, Alicia Steffens, Jordain Walshon, Kathleen McCortney, Sabine Heiland, Martin Bendszus, Peter Neher, Anna Golebiewska, Wolfgang Wick, Frank Winkler, Michael O. Breckwoldt, Anna Kreshuk, Thomas Kuner, Craig Horbinski, Felix Tobias Kurz, Robert Prevedel, and Varun Venkataramani
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Science - Abstract
Abstract Intravital 2P-microscopy enables the longitudinal study of brain tumor biology in superficial mouse cortex layers. Intravital microscopy of the white matter, an important route of glioblastoma invasion and recurrence, has not been feasible, due to low signal-to-noise ratios and insufficient spatiotemporal resolution. Here, we present an intravital microscopy and artificial intelligence-based analysis workflow (Deep3P) that enables longitudinal deep imaging of glioblastoma up to a depth of 1.2 mm. We find that perivascular invasion is the preferred invasion route into the corpus callosum and uncover two vascular mechanisms of glioblastoma migration in the white matter. Furthermore, we observe morphological changes after white matter infiltration, a potential basis of an imaging biomarker during early glioblastoma colonization. Taken together, Deep3P allows for a non-invasive intravital investigation of brain tumor biology and its tumor microenvironment at subcortical depths explored, opening up opportunities for studying the neuroscience of brain tumors and other model systems.
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- 2024
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3. Deep intravital brain tumor imaging enabled by tailored three-photon microscopy and analysis
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Schubert, Marc Cicero, Soyka, Stella Judith, Tamimi, Amr, Maus, Emanuel, Schroers, Julian, Wißmann, Niklas, Reyhan, Ekin, Tetzlaff, Svenja Kristin, Yang, Yvonne, Denninger, Robert, Peretzke, Robin, Beretta, Carlo, Drumm, Michael, Heuer, Alina, Buchert, Verena, Steffens, Alicia, Walshon, Jordain, McCortney, Kathleen, Heiland, Sabine, Bendszus, Martin, Neher, Peter, Golebiewska, Anna, Wick, Wolfgang, Winkler, Frank, Breckwoldt, Michael O., Kreshuk, Anna, Kuner, Thomas, Horbinski, Craig, Kurz, Felix Tobias, Prevedel, Robert, and Venkataramani, Varun
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- 2024
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4. Glioblastoma-instructed microglia transition to heterogeneous phenotypic states with phagocytic and dendritic cell-like features in patient tumors and patient-derived orthotopic xenografts
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Yabo, Yahaya A., Moreno-Sanchez, Pilar M., Pires-Afonso, Yolanda, Kaoma, Tony, Nosirov, Bakhtiyor, Scafidi, Andrea, Ermini, Luca, Lipsa, Anuja, Oudin, Anaïs, Kyriakis, Dimitrios, Grzyb, Kamil, Poovathingal, Suresh K., Poli, Aurélie, Muller, Arnaud, Toth, Reka, Klink, Barbara, Berchem, Guy, Berthold, Christophe, Hertel, Frank, Mittelbronn, Michel, Heiland, Dieter H., Skupin, Alexander, Nazarov, Petr V., Niclou, Simone P., Michelucci, Alessandro, and Golebiewska, Anna
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- 2024
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5. Magnetic resonance imaging-guided intracranial resection of glioblastoma tumors in patient-derived orthotopic xenografts leads to clinically relevant tumor recurrence
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Oudin, Anais, Moreno-Sanchez, Pilar M., Baus, Virginie, Niclou, Simone P., and Golebiewska, Anna
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- 2024
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6. Stabilization of stochastic dynamical systems of a random structure with Markov switches and Poisson perturbations
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Lukashiv, Taras, Litvinchuk, Yuliia, Malyk, Igor, Golebiewska, Anna, and Nazarov, Petr V.
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Mathematics - Optimization and Control ,Mathematics - Probability ,60J25, 93C73, 93E03, 93E15 - Abstract
An optimal control for a dynamical system optimizes a certain objective function. Here we consider the construction of an optimal control for a stochastic dynamical system with a random structure, Poisson perturbations and random jumps, which makes the system stable in probability. Sufficient conditions of the stability in probability are obtained, using the second Lyapunov method, in which the construction of the corresponding functions plays an important role. Here we provide a solution to the problem of optimal stabilization in a general case. For a linear system with a quadratic quality function, we give a method of synthesis of optimal control based on the solution of Riccati equations. Finally, in an autonomous case, a system of differential equations was constructed to obtain unknown matrices that are used for the building of an optimal control. The method of a small parameter is justified for the algorithmic search of an optimal control. This approach brings a novel solution to the problem of optimal stabilization for a stochastic dynamical system with a random structure, Markov switches and Poisson perturbations., Comment: 15 pages, 0 figures, 25 references
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- 2022
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7. An inclusive Research and Education Community (iREC) model to facilitate undergraduate science education reform
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Denise L. Monti, Julia C. Gill, Tamarah L. Adair, Sandra D. Adams, Yesmi Patricia Ahumada-Santos, Isabel Amaya, Kirk Anders, Justin R. Anderson, Mauricio S. Antunes, Mary Ayuk, Frederick Baliraine, Tonya C. Bates, Andrea R. Beyer, Suparna Bhalla, Tejas Bouklas, Sharon K. Bullock, Kristen A. Butela, Christine Byrum, Steven M. Caruso, Rebecca Chong, Hui-Min Chung, Stephanie B. Conant, Brett Condon, Katie E. Crump, Tom D'Elia, Megan K. Dennis, Linda C. DeVeaux, Lautaro Diacovich, Arturo Diaz, Iain Duffy, Dustin Edwards, Patricia C. Fallest-Strobl, Ann Findley, Matthew R. Fisher, Marie P. Fogarty, Victoria Jane Frost, Maria D. Gainey, Courtney S. Galle, Bryan Gibb, Urszula Golebiewska, Hugo Gramajo, Anna S. Grinath, Jennifer Guerrero, Nancy Guild, Kathryn E. Gunn, Susan Gurney, Lee E. Hughes, Pradeepa Jayachandran, Kristen Johnson, Allison Johnson, Alison E. Kanak, Michelle L. Kanther, Rodney A. King, Kathryn Kohl, Julia Lee-Soety, Lynn O. Lewis, Heather Lindberg, Jaclyn A. Madden, Breonna J. Martin, Matthew D. Mastropaolo, Sean McClory, Evan C. Merkhofer, Julie A. Merkle, Jon Mitchell, María Alejandra Mussi, Fernando Nieto, Jillian Nissen, Imade Yolanda Nsa, Mary G. O'Donnell, R. Deborah Overath, Shallee T. Page, Andrea Panagakis, Jesús Ricardo Parra Unda, Michelle B. Pass, Tiara Perez Morales, Nick T. Peters, Ruth Plymale, Richard Pollenz, Nathan S. Reyna, Claire A. Rinehart, Jessica Rocheleau, John S. Rombold, Ombeline Rossier, Adam D. Rudner, Elizabeth E. Rueschhoff, Christopher D. Shaffer, Mary Ann V. Smith, Amy B. Sprenkle, C. Nicole Sunnen, Michael A. Thomas, Michelle M. Tigges, Deborah Tobiason, Sara Sybesma Tolsma, Julie Torruellas Garcia, Peter Uetz, Edwin Vazquez, Catherine M. Ward, Vassie C. Ware, Jacqueline M. Washington, Matthew J. Waterman, Daniel E. Westholm, Keith A. Wheaton, Simon J. White, Elizabeth C. Williams, Daniel C. Williams, Ellen M. Wisner, William H. Biederman, Steven G. Cresawn, Danielle M. Heller, Deborah Jacobs-Sera, Daniel A. Russell, Graham F. Hatfull, David J. Asai, David I. Hanauer, Mark J. Graham, and Viknesh Sivanathan
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Science Education Alliance ,inclusive Research and Education Community ,pathway modeling ,course-based research experience ,STEM faculty development ,Education (General) ,L7-991 - Abstract
Over the last two decades, there have been numerous initiatives to improve undergraduate student outcomes in STEM. One model for scalable reform is the inclusive Research Education Community (iREC). In an iREC, STEM faculty from colleges and universities across the nation are supported to adopt and sustainably implement course-based research – a form of science pedagogy that enhances student learning and persistence in science. In this study, we used pathway modeling to develop a qualitative description that explicates the HHMI Science Education Alliance (SEA) iREC as a model for facilitating the successful adoption and continued advancement of new curricular content and pedagogy. In particular, outcomes that faculty realize through their participation in the SEA iREC were identified, organized by time, and functionally linked. The resulting pathway model was then revised and refined based on several rounds of feedback from over 100 faculty members in the SEA iREC who participated in the study. Our results show that in an iREC, STEM faculty organized as a long-standing community of practice leverage one another, outside expertise, and data to adopt, implement, and iteratively advance their pedagogy. The opportunity to collaborate in this manner and, additionally, to be recognized for pedagogical contributions sustainably engages STEM faculty in the advancement of their pedagogy. Here, we present a detailed pathway model of SEA that, together with underpinning features of an iREC identified in this study, offers a framework to facilitate transformations in undergraduate science education.
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- 2024
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8. Glioblastoma-instructed microglia transition to heterogeneous phenotypic states with phagocytic and dendritic cell-like features in patient tumors and patient-derived orthotopic xenografts
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Yahaya A. Yabo, Pilar M. Moreno-Sanchez, Yolanda Pires-Afonso, Tony Kaoma, Bakhtiyor Nosirov, Andrea Scafidi, Luca Ermini, Anuja Lipsa, Anaïs Oudin, Dimitrios Kyriakis, Kamil Grzyb, Suresh K. Poovathingal, Aurélie Poli, Arnaud Muller, Reka Toth, Barbara Klink, Guy Berchem, Christophe Berthold, Frank Hertel, Michel Mittelbronn, Dieter H. Heiland, Alexander Skupin, Petr V. Nazarov, Simone P. Niclou, Alessandro Michelucci, and Anna Golebiewska
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Glioblastoma ,Tumor microenvironment ,Myeloid cells ,Microglia ,Patient-derived orthotopic xenografts ,Single-cell RNA sequencing ,Medicine ,Genetics ,QH426-470 - Abstract
Abstract Background A major contributing factor to glioblastoma (GBM) development and progression is its ability to evade the immune system by creating an immune-suppressive environment, where GBM-associated myeloid cells, including resident microglia and peripheral monocyte-derived macrophages, play critical pro-tumoral roles. However, it is unclear whether recruited myeloid cells are phenotypically and functionally identical in GBM patients and whether this heterogeneity is recapitulated in patient-derived orthotopic xenografts (PDOXs). A thorough understanding of the GBM ecosystem and its recapitulation in preclinical models is currently missing, leading to inaccurate results and failures of clinical trials. Methods Here, we report systematic characterization of the tumor microenvironment (TME) in GBM PDOXs and patient tumors at the single-cell and spatial levels. We applied single-cell RNA sequencing, spatial transcriptomics, multicolor flow cytometry, immunohistochemistry, and functional studies to examine the heterogeneous TME instructed by GBM cells. GBM PDOXs representing different tumor phenotypes were compared to glioma mouse GL261 syngeneic model and patient tumors. Results We show that GBM tumor cells reciprocally interact with host cells to create a GBM patient-specific TME in PDOXs. We detected the most prominent transcriptomic adaptations in myeloid cells, with brain-resident microglia representing the main population in the cellular tumor, while peripheral-derived myeloid cells infiltrated the brain at sites of blood–brain barrier disruption. More specifically, we show that GBM-educated microglia undergo transition to diverse phenotypic states across distinct GBM landscapes and tumor niches. GBM-educated microglia subsets display phagocytic and dendritic cell-like gene expression programs. Additionally, we found novel microglial states expressing cell cycle programs, astrocytic or endothelial markers. Lastly, we show that temozolomide treatment leads to transcriptomic plasticity and altered crosstalk between GBM tumor cells and adjacent TME components. Conclusions Our data provide novel insights into the phenotypic adaptation of the heterogeneous TME instructed by GBM tumors. We show the key role of microglial phenotypic states in supporting GBM tumor growth and response to treatment. Our data place PDOXs as relevant models to assess the functionality of the TME and changes in the GBM ecosystem upon treatment. Graphical Abstract
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- 2024
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9. Magnetic resonance imaging-guided intracranial resection of glioblastoma tumors in patient-derived orthotopic xenografts leads to clinically relevant tumor recurrence
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Anais Oudin, Pilar M. Moreno-Sanchez, Virginie Baus, Simone P. Niclou, and Anna Golebiewska
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Glioblastoma ,Patient-derived orthotopic xenograft ,Brain surgery ,Tumor resection ,In vivo imaging ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Preclinical in vivo cancer models are essential tools for investigating tumor progression and response to treatment prior to clinical trials. Although treatment modalities are regularly assessed in mice upon tumor growth in vivo, surgical resection remains challenging, particularly in the orthotopic site. Here, we report a successful surgical resection of glioblastoma (GBM) in patient-derived orthotopic xenografts (PDOXs). Methods We derived a cohort of 46 GBM PDOX models that faithfully recapitulate human disease in mice. We assessed the detection and quantification of intracranial tumors using magnetic resonance imaging (MRI).To evaluate feasibility of surgical resection in PDOXs, we selected two models representing histopathological features of GBM tumors, including diffuse growth into the mouse brain. Surgical resection in the mouse brains was performed based on MRI-guided coordinates. Survival study followed by MRI and immunohistochemistry-based evaluation of recurrent tumors allowed for assessment of clinically relevant parameters. Results We demonstrate the utility of MRI for the noninvasive assessment of in vivo tumor growth, preoperative programming of resection coordinates and follow-up of tumor recurrence. We report tumor detection by MRI in 90% of GBM PDOX models (36/40), of which 55% (22/40) can be reliably quantified during tumor growth. We show that a surgical resection protocol in mice carrying diffuse primary GBM tumors in the brain leads to clinically relevant outcomes. Similar to neurosurgery in patients, we achieved a near total to complete extent of tumor resection, and mice with resected tumors presented significantly increased survival. The remaining unresected GBM cells that invaded the normal mouse brain prior to surgery regrew tumors with similar histopathological features and tumor microenvironments to the primary tumors. Conclusions Our data positions GBM PDOXs developed in mouse brains as a valuable preclinical model for conducting therapeutic studies that involve surgical tumor resection. The high detectability of tumors by MRI across a substantial number of PDOX models in mice will allow for scalability of our approach toward specific tumor types for efficacy studies in precision medicine-oriented approaches. Additionally, these models hold promise for the development of enhanced image-guided surgery protocols.
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- 2024
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10. UV-B-induced modulation of constitutive heterochromatin content in Arabidopsis thaliana
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Johann to Berens, Philippe, Golebiewska, Kinga, Peter, Jackson, Staerck, Sébastien, and Molinier, Jean
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- 2023
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11. Patient-based multilevel transcriptome exploration highlights relevant chemokines and chemokine receptor axes in glioblastoma
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D'Uonnolo, Giulia, Isci, Damla, Nosirov, Bakhtiyor, Kuppens, Amandine, Wantz, May, Nazarov, Petr V., Golebiewska, Anna, Rogister, Bernard, Chevigné, Andy, Neirinckx, Virginie, and Szpakowska, Martyna
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- 2024
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12. Periodic solutions to symmetric Newtonian systems in neighborhoods of orbits of equilibria
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Gołębiewska, Anna, Kowalczyk, Marta, Rybicki, Sławomir, and Stefaniak, Piotr
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Mathematics - Dynamical Systems ,Mathematics - Classical Analysis and ODEs ,Primary: 37J46, Secondary: 37J20 - Abstract
The aim of this paper is to prove the existence of periodic solutions to symmetric Newtonian systems in any neighborhood of an isolated orbit of equilibria. Applying equivariant bifurcation techniques we obtain a generalization of the classical Lyapunov center theorem to the case of symmetric potentials with orbits of non-isolated critical points. Our tool is an equivariant version of the Conley index. To compare the indices we compute cohomological dimensions of some orbit spaces.
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- 2021
13. Bifurcation of closed orbits from equilibria of Newtonian systems with Coriolis forces
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Gołȩbiewska, Anna, Pérez-Chavela, Ernesto, Rybicki, Sławomir, and Ureña, Antonio J.
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Mathematics - Dynamical Systems ,Mathematics - Classical Analysis and ODEs ,70F15, 37N05, 37G15 - Abstract
We consider autonomous Newtonian systems with Coriolis forces in two and three dimensions and study the existence of branches of periodic orbits emanating from equilibria. We investigate both degenerate and nondegenerate situations. While Lyapunov's center theorem applies locally in the nondegenerate, nonresonant context, equivariant degree theory provides a global answer which is significant also in some degenerate cases. We apply our abstract results to a problem from Celestial Mechanics. More precisely, in the three-dimensional version of the Restricted Triangular Four Body Problem with possibly different primaries our results show the existence of at least seven branches of periodic orbits emanating from the stationary points., Comment: 2 figures
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- 2021
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14. Hybrid geothermal-fossil power cycle analysis in a Polish setting with a focus on off-design performance and CO2 emissions reductions
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Szturgulewski, Kacper, Głuch, Jerzy, Drosińska-Komor, Marta, Ziółkowski, Paweł, Gardzilewicz, Andrzej, and Brzezińska-Gołębiewska, Katarzyna
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- 2024
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15. Structural and mechanistic insights into the transport of aristolochic acids and their active metabolites by human serum albumin
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Pomyalov, Sergei, Minetti, Conceição A., Remeta, David P., Bonala, Radha, Johnson, Francis, Zaitseva, Irina, Iden, Charles, Golebiewska, Urszula, Breslauer, Kenneth J., Shoham, Gil, Sidorenko, Viktoriya S., and Grollman, Arthur P.
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- 2024
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16. Advancing preclinical cancer models to assess clinically relevant outcomes
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Golebiewska, Anna and Fields, Ryan C.
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- 2023
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17. Instructional Models for Course-Based Research Experience (CRE) Teaching
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Hanauer, David I, Graham, Mark J, Arnold, Rachel J, Ayuk, Mary A, Balish, Mitchell F, Beyer, Andrea R, Butela, Kristen A, Byrum, Christine A, Chia, Catherine P, Chung, Hui-Min, Clase, Kari L, Conant, Stephanie, Coomans, Roy J, D’Elia, Tom, Diaz, Jason, Diaz, Arturo, Doty, Jean A, Edgington, Nicholas P, Edwards, Dustin C, Eivazova, Elvira, Emmons, Christine B, Fast, Kayla M, Fisher, Emily J, Fleischacker, Christine L, Frederick, Gregory D, Freise, Amanda C, Gainey, Maria D, Gissendanner, Chris R, Golebiewska, Urszula P, Guild, Nancy A, Hendrickson, Heather L, Herren, Christopher D, Hopson-Fernandes, Margaret S, Hughes, Lee E, Jacobs-Sera, Deborah, Johnson, Allison A, Kirkpatrick, Bridgette L, Klyczek, Karen K, Koga, Ann P, Kotturi, Hari, LeBlanc-Straceski, Janine, Lee-Soety, Julia Y, Leonard, Justin E, Mastropaolo, Matthew D, Merkhofer, Evan C, Michael, Scott F, Mitchell, Jon C, Mohan, Swarna, Monti, Denise L, Noutsos, Christos, Nsa, Imade Y, Peters, Nick T, Plymale, Ruth, Pollenz, Richard S, Porter, Megan L, Rinehart, Claire A, Rosas-Acosta, German, Ross, Joseph F, Rubin, Michael R, Scherer, Anne E, Schroeder, Stephanie C, Shaffer, Christopher D, Sprenkle, Amy B, Sunnen, C Nicole, Swerdlow, Sarah J, Tobiason, Deborah, Tolsma, Sara S, Tsourkas, Philippos K, Ward, Robert E, Ware, Vassie C, Warner, Marcie H, Washington, Jacqueline M, Westover, Kristi M, White, Simon J, Whitefleet-Smith, JoAnn L, Williams, Daniel C, Wolyniak, Michael J, Zeilstra-Ryalls, Jill H, Asai, David J, Hatfull, Graham F, and Sivanathan, Viknesh
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Curriculum and Pedagogy ,Education Systems ,Education ,Quality Education ,Engineering ,Faculty ,Humans ,Mathematics ,Models ,Educational ,Students ,Teaching ,Curriculum and pedagogy - Abstract
The course-based research experience (CRE) with its documented educational benefits is increasingly being implemented in science, technology, engineering, and mathematics education. This article reports on a study that was done over a period of 3 years to explicate the instructional processes involved in teaching an undergraduate CRE. One hundred and two instructors from the established and large multi-institutional SEA-PHAGES program were surveyed for their understanding of the aims and practices of CRE teaching. This was followed by large-scale feedback sessions with the cohort of instructors at the annual SEA Faculty Meeting and subsequently with a small focus group of expert CRE instructors. Using a qualitative content analysis approach, the survey data were analyzed for the aims of inquiry instruction and pedagogical practices used to achieve these goals. The results characterize CRE inquiry teaching as involving three instructional models: 1) being a scientist and generating data; 2) teaching procedural knowledge; and 3) fostering project ownership. Each of these models is explicated and visualized in terms of the specific pedagogical practices and their relationships. The models present a complex picture of the ways in which CRE instruction is conducted on a daily basis and can inform instructors and institutions new to CRE teaching.
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- 2022
18. Bifurcations from degenerate orbits of solutions of nonlinear elliptic systems
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Gołębiewska, Anna, Kluczenko, Joanna, and Stefaniak, Piotr
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Mathematics - Analysis of PDEs - Abstract
The aim of this paper is to study global bifurcations of non-constant solutions of some nonlinear elliptic systems, namely the system on a sphere and the Neumann problem on a ball. We study the bifurcation phenomenon from families of constant solutions given by critical points of the potentials. Considering this problem in the presence of additional symmetries of a compact Lie group, we study orbits of solutions and, in particular, we do not require the critical points to be isolated. Moreover, we allow the considered orbits of critical points to be degenerate. To prove the bifurcation we compute the index of an isolated degenerate critical orbit in an abstract situation. This index is given in terms of the degree for equivariant gradient maps.
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- 2021
19. Comparative analysis of deeply phenotyped GBM cohorts of ‘short-term’ and ‘long-term’ survivors
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Biswas, Archita, Salvucci, Manuela, Connor, Kate, Düssmann, Heiko, Carberry, Steven, Fichtner, Michael, King, Ellen, Murphy, Brona, O’Farrell, Alice C., Cryan, Jane, Beausang, Alan, Heffernan, Josephine, Cremona, Mattia, Hennessy, Bryan T., Clerkin, James, Sweeney, Kieron J., MacNally, Steve, Brett, Francesca, O’Halloran, Philip, Bacon, Orna, Furney, Simon, Verreault, Maite, Quissac, Emie, Bielle, Franck, Ahmed, Mohammed H., Idbaih, Ahmed, Leenstra, Sieger, Ntafoulis, Ioannis, Fabro, Federica, Lamfers, Martine, Golebiewska, Anna, Hertel, Frank, Niclou, Simone P., Yen, Romain Tching Chi, Kremer, Andreas, Dilcan, Gonca, Lodi, Francesca, Arijs, Ingrid, Lambrechts, Diether, Purushothama, Manasa Kalya, Kel, Alexander, Byrne, Annette T., and Prehn, Jochen H.M.
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- 2023
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20. Investor sentiment response to COVID-19 outbreak-related news: A sectoral analysis of US firms
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Blajer-Gołębiewska, Anna, Honecker, Lukas, and Nowak, Sabina
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- 2024
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21. Structure of sets of solutions of parametrised semi-linear elliptic systems on spheres
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Gołębiewska, Anna and Stefaniak, Piotr
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Mathematics - Analysis of PDEs ,Primary: 35J50, Secondary: 35B32 - Abstract
In this paper we study a parametrised non-cooperative symmetric semi-linear elliptic system on a sphere. Assuming that there exist critical orbits of the potential, we study the structure of the sets of solutions of the system. In particular, using the equivariant Rabinowitz Alternative we formulate sufficient conditions for a bifurcation of unbounded sets of solutions.
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- 2020
22. Models of classroom assessment for course-based research experiences
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David I. Hanauer, Tong Zhang, Mark J. Graham, Sandra D. Adams, Yesmi Patricia Ahumada-Santos, Richard M. Alvey, Mauricio S. Antunes, Mary A. Ayuk, María Elena Báez-Flores, Christa T. Bancroft, Tonya C. Bates, Meghan J. Bechman, Elizabeth Behr, Andrea R. Beyer, Rebecca L. Bortz, Dane M. Bowder, Laura A. Briggs, Victoria Brown-Kennerly, Michael A. Buckholt, Sharon K. Bullock, Kristen A. Butela, Christine A. Byrum, Steven M. Caruso, Catherine P. Chia, Rebecca A. Chong, Hui-Min Chung, Kari L. Clase, Sean T. Coleman, D. Parks Collins, Stephanie B. Conant, Brett M. Condon, Pamela L. Connerly, Bernadette J. Connors, Jennifer E. Cook-Easterwood, Katie E. Crump, Tom D’Elia, Megan K. Dennis, Linda C. DeVeaux, Lautaro Diacovich, Iain Duffy, Nicholas P. Edgington, Dustin C. Edwards, Tenny O. G. Egwuatu, Elvira R. Eivazova, Patricia C. Fallest-Strobl, Christy L. Fillman, Ann M. Findley, Emily Fisher, Matthew R. Fisher, Marie P. Fogarty, Amanda C. Freise, Victoria J. Frost, Maria D. Gainey, Amaya M. Garcia Costas, Atenea A. Garza, Hannah E. Gavin, Raffaella Ghittoni, Bryan Gibb, Urszula P. Golebiewska, Anna S. Grinath, Susan M. R. Gurney, Rebekah F. Hare, Steven G. Heninger, John M. Hinz, Lee E. Hughes, Pradeepa Jayachandran, Kristen C. Johnson, Allison A. Johnson, Michelle Kanther, Margaret Kenna, Bridgette L. Kirkpatrick, Karen K. Klyczek, Kathryn P. Kohl, Michael Kuchka, Amber J. LaPeruta, Julia Y. Lee-Soety, Lynn O. Lewis, Heather M. Lindberg, Jaclyn A. Madden, Sergei A. Markov, Matthew D. Mastropaolo, Vinayak Mathur, Sean P. McClory, Evan C. Merkhofer, Julie A. Merkle, Scott F. Michael, Jon C. Mitchell, Sally D. Molloy, Denise L. Monti, María Alejandra Mussi, Holly Nance, Fernando E. Nieto-Fernandez, Jillian C. Nissen, Imade Y. Nsa, Mary G. O’Donnell, Shallee T. Page, Andrea Panagakis, Jesús Ricardo Parra-Unda, Tara A. Pelletier, Tiara G. Perez Morales, Nick T. Peters, Vipaporn Phuntumart, Richard S. Pollenz, Mary L. Preuss, David P. Puthoff, Muideen K. Raifu, Nathan S. Reyna, Claire A. Rinehart, Jessica M. Rocheleau, Ombeline Rossier, Adam D. Rudner, Elizabeth E. Rueschhoff, Amy Ryan, Sanghamitra Saha, Christopher D. Shaffer, Mary Ann V. Smith, Amy B. Sprenkle, Christy L. Strong, C. Nicole Sunnen, Brian P. Tarbox, Louise Temple, Kara R. Thoemke, Michael A. Thomas, Deborah M. Tobiason, Sara S. Tolsma, Julie Torruellas Garcia, Megan S. Valentine, Edwin Vazquez, Robert E. Ward, Catherine M. Ward, Vassie C. Ware, Marcie H. Warner, Jacqueline M. Washington, Daniel E. Westholm, Keith A. Wheaton, Beth M. Wilkes, Elizabeth C. Williams, William H. Biederman, Steven G. Cresawn, Danielle M. Heller, Deborah Jacobs-Sera, Graham F. Hatfull, David J. Asai, and Viknesh Sivanathan
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course-based research experience (CURE) ,science education ,assessment ,intergrated research and education community (iREC) ,grading ,Education (General) ,L7-991 - Abstract
Course-based research pedagogy involves positioning students as contributors to authentic research projects as part of an engaging educational experience that promotes their learning and persistence in science. To develop a model for assessing and grading students engaged in this type of learning experience, the assessment aims and practices of a community of experienced course-based research instructors were collected and analyzed. This approach defines four aims of course-based research assessment—(1) Assessing Laboratory Work and Scientific Thinking; (2) Evaluating Mastery of Concepts, Quantitative Thinking and Skills; (3) Appraising Forms of Scientific Communication; and (4) Metacognition of Learning—along with a set of practices for each aim. These aims and practices of assessment were then integrated with previously developed models of course-based research instruction to reveal an assessment program in which instructors provide extensive feedback to support productive student engagement in research while grading those aspects of research that are necessary for the student to succeed. Assessment conducted in this way delicately balances the need to facilitate students’ ongoing research with the requirement of a final grade without undercutting the important aims of a CRE education.
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- 2023
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23. Connected sets of solutions of symmetric elliptic systems
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Gołębiewska, Anna, Rybicki, Sławomir, and Stefaniak, Piotr
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Mathematics - Analysis of PDEs - Abstract
The purpose of this paper is twofold. First we study bifurcations of connected sets of critical orbits of some invariant functional from a given family of critical orbits. We use techniques of equivariant bifurcation theory to obtain a Rabinowitz type alternative for symmetric gradient operators. The second aim is to apply the abstract results to studying orbits of nonconstant solutions of a nonlinear Neumann problem.
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- 2019
24. Immune cell identity behind the Ktrans mapping of mouse glioblastoma
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Zhang, Yanrong, Keunen, Olivier, Golebiewska, Anna, Gerosa, Marco, Wang, Jing, Ghobadi, Sara Natasha, Huang, Ai, Hou, Qingyi, Habte, Frezghi G., Li, Ningrui, Grant, Gerry, Paulmurugan, Ramasamy, Lee, Kevin S., and Wintermark, Max
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- 2023
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25. Instructional Models for Course-Based Research Experience (CRE) Teaching
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Hanauer, David I., Graham, Mark J., Arnold, Rachel J., Ayuk, Mary A., Balish, Mitchell F., Beyer, Andrea R., Butela, Kristen A., Byrum, Christine A., Chia, Catherine P., Chung, Hui-Min, Clase, Kari L., Conant, Stephanie, Coomans, Roy J., D'Elia, Tom, Diaz, Jason, Diaz, Arturo, Doty, Jean A., Edgington, Nicholas P., Edwards, Dustin C., Eivazova, Elvira, Emmons, Christine B., Fast, Kayla M., Fisher, Emily J., Fleischacker, Christine L., Frederick, Gregory D., Freise, Amanda C., Gainey, Maria D., Gissendanner, Chris R., Golebiewska, Urszula P., Guild, Nancy A., Hendrickson, Heather L., Herren, Christopher D., Hopson-Fernandes, Margaret S., Hughes, Lee E., Jacobs-Sera, Deborah, Johnson, Allison A., Kirkpatrick, Bridgette L., Klyczek, Karen K., Koga, Ann P., Kotturi, Hari, LeBlanc-Straceski, Janine, Lee-Soety, Julia Y., Leonard, Justin E., Mastropaolo, Matthew D., Merkhofer, Evan C., Michael, Scott F., Mitchell, Jon C., Mohan, Swarna, Monti, Denise L., Noutsos, Christos, Nsa, Imade Y., Peters, Nick T., Plymale, Ruth, Pollenz, Richard S., Porter, Megan L., Rinehart, Claire A., Rosas-Acosta, German, Ross, Joseph F., Rubin, Michael R., Scherer, Anne E., Schroeder, Stephanie C., Shaffer, Christopher D., Sprenkle, Amy B., Sunnen, C. Nicole, Swerdlow, Sarah J., Tobiason, Deborah, Tolsma, Sara S., Tsourkas, Philippos K., Ward, Robert E., Ware, Vassie C., Warner, Marcie H., Washington, Jacqueline M., Westover, Kristi M., White, Simon J., Whitefleet-Smith, JoAnn L., Williams, Daniel C., Wolyniak, Michael J., Zeilstra-Ryalls, Jill H., Asai, David J., Hatfull, Graham F., and Sivanathan, Viknesh
- Abstract
The course-based research experience (CRE) with its documented educational benefits is increasingly being implemented in science, technology, engineering, and mathematics education. This article reports on a study that was done over a period of 3 years to explicate the instructional processes involved in teaching an undergraduate CRE. One hundred and two instructors from the established and large multi-institutional SEA-PHAGES program were surveyed for their understanding of the aims and practices of CRE teaching. This was followed by large-scale feedback sessions with the cohort of instructors at the annual SEA Faculty Meeting and subsequently with a small focus group of expert CRE instructors. Using a qualitative content analysis approach, the survey data were analyzed for the aims of inquiry instruction and pedagogical practices used to achieve these goals. The results characterize CRE inquiry teaching as involving three instructional models: (1) being a scientist and generating data; (2) teaching procedural knowledge; and (3) fostering project ownership. Each of these models is explicated and visualized in terms of the specific pedagogical practices and their relationships. The models present a complex picture of the ways in which CRE instruction is conducted on a daily basis and can inform instructors and institutions new to CRE teaching.
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- 2022
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26. Properties of LiMnBO3 glasses and nanostructured glass-ceramics
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Michalski, P. P., Gołębiewska, A., Trébosc, J., Lafon, O., Pietrzak, T. K., Ryl, J., Nowiński, J. L., Wasiucionek, M., and Garbarczyk, J. E.
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Condensed Matter - Materials Science ,Condensed Matter - Soft Condensed Matter - Abstract
Polycrystalline LiMnBO3 is a promising cathode material for Li-ion batteries. In this work, we investigated the thermal, structural and electrical properties of glassy and nanocrystallized materials having the same chemical composition. The original glass was obtained via a standard meltquenching method. SEM and 7Li solid-state NMR indicate that it contains a mixture of two distinct glassy phases. The results suggest that the electrical conductivity of the glass is dominated by the ionic one. The dc conductivity of initial glass was estimated to be in the order of 10-18 S.cm-1 at room temperature. The thermal nanocrystallization of the glass produces a nanostructured glass-ceramics containing MnBO3 and LiMnBO3 phases. The electric conductivity of this glass-ceramics is increased by 6 orders of magnitude, compared to the starting material at room temperature. Compared to other manganese and borate containing glasses reported in the literature, the conductivity of the nanostructured glass ceramics is higher than that of the previously reported glassy materials. Such improved conductivity stems from the facilitated electronic transport along the grain boundaries.
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- 2019
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27. Molecular Identity Changes of Tumor-Associated Macrophages and Microglia After Magnetic Resonance Imaging–Guided Focused Ultrasound–Induced Blood–Brain Barrier Opening in a Mouse Glioblastoma Model
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Zhang, Yanrong, Wang, Jing, Ghobadi, Sara Natasha, Zhou, Haiyan, Huang, Ai, Gerosa, Marco, Hou, Qingyi, Keunen, Olivier, Golebiewska, Anna, Habte, Frezghi G., Grant, Gerald A., Paulmurugan, Ramasamy, Lee, Kevin S., and Wintermark, Max
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- 2023
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28. Advancing preclinical cancer models to assess clinically relevant outcomes
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Anna Golebiewska and Ryan C. Fields
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Cancer models are indispensable research tools for elucidating the mechanisms involved in tumor onset, progression and treatment resistance. They are key in evaluating therapeutics prior clinical trials. In this editorial, we invite contributions for a BMC Cancer’s Collection of articles addressing ‘Advances in pre-clinical cancer models’ towards relivable outcomes at the preclinical stage.
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- 2023
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29. Elucidating tumour‐associated microglia/macrophage diversity along glioblastoma progression and under ACOD1 deficiency
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Yolanda Pires‐Afonso, Arnaud Muller, Kamil Grzyb, Anaïs Oudin, Yahaya A. Yabo, Carole Sousa, Andrea Scafidi, Aurélie Poli, Antonio Cosma, Rashi Halder, Djalil Coowar, Anna Golebiewska, Alexander Skupin, Simone P. Niclou, and Alessandro Michelucci
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ACOD1/IRG1 ,glioblastoma ,heterogeneity ,metabolic reprogramming ,single‐cell RNA‐sequencing ,tumour‐associated microglia/macrophages ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
In glioblastoma (GBM), tumour‐associated microglia/macrophages (TAMs) represent the major cell type of the stromal compartment and contribute to tumour immune escape mechanisms. Thus, targeting TAMs is emerging as a promising strategy for immunotherapy. However, TAM heterogeneity and metabolic adaptation along GBM progression represent critical features for the design of effective TAM‐targeted therapies. Here, we comprehensively study the cellular and molecular changes of TAMs in the GL261 GBM mouse model, combining single‐cell RNA‐sequencing with flow cytometry and immunohistological analyses along GBM progression and in the absence of Acod1 (also known as Irg1), a key gene involved in the metabolic reprogramming of macrophages towards an anti‐inflammatory phenotype. Similarly to patients, we identify distinct TAM profiles, mainly based on their ontogeny, that reiterate the idea that microglia‐ and macrophage‐like cells show key transcriptional differences and dynamically adapt along GBM stages. Notably, we uncover decreased antigen‐presenting cell features and immune reactivity in TAMs along tumour progression that are instead enhanced in Acod1‐deficient mice. Overall, our results provide insight into TAM heterogeneity and highlight a novel role for Acod1 in TAM adaptation during GBM progression.
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- 2022
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30. Effect of reputation and social media on the financial performance of SMEs – a comparison between selected business sectors
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Blajer-Golebiewska, Anna, primary and Vasa, Laszlo, additional
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- 2024
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31. Global bifurcation index of critical orbit of strongly indefinite functional
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Gołębiewska, Anna and Stefaniak, Piotr
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Mathematics - Analysis of PDEs ,58E09 (Primary), 35J50 (Secondary) - Abstract
In this paper we study an index of a critical orbit, defined in terms of the degree for invariant strongly indefinite functionals. We establish a relationship of this index with the index of a critical point of the mapping restricted to the space normal to the orbit. The second aim of the article is to use the index of a critical orbit to prove the bifurcation of nontrivial solutions of nonlinear elliptic systems with Neumann boundary conditions. We consider also the existence of unbounded sets of solutions of such systems.
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- 2018
32. Bifurcation of closed orbits from equilibria of Newtonian systems with Coriolis forces
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Gołȩbiewska, Anna, Pérez-Chavela, Ernesto, Rybicki, Sławomir, and Ureña, Antonio J.
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- 2022
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33. Water – A life-giving toxin – A nephrological oxymoron. Health consequences of water and sodium balance disorders. A review article
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Mitrosz-Gołębiewska, Katarzyna, Rydzewska–Rosołowska, Alicja, Kakareko, Katarzyna, Zbroch, Edyta, and Hryszko, Tomasz
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- 2022
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34. Bifurcations from the orbit of solutions of the Neumann problem
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Gołębiewska, Anna, Kluczenko, Joanna, and Stefaniak, Piotr
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Mathematics - Analysis of PDEs - Abstract
The purpose of this paper is to study weak solutions of a nonlinear Neumann problem considered on a ball. Assuming that the potential is invariant, we consider an orbit of critical points, i.e. we do not assume that critical points are isolated. We apply techniques of the equivariant analysis to examine bifurcations from the orbits of trivial solutions. We formulate sufficient conditions for local and global bifurcations, in terms of the right-hand side of the system and eigenvalues of the Laplace operator. Moreover, we characterise orbits at which the global symmetry-breaking phenomenon occurs.
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- 2017
35. Peptides as versatile scaffolds for quantum computing
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Rosaleny, Lorena E., Forment-Aliaga, Alicia, Prima-García, Helena, Cavanillas, Ramón Torres, Baldoví, José J., Gołȩbiewska, Violetta, Wlazło, Karolina, Escorcia-Ariza, Garin, Escalera-Moreno, Luis, Tatay, Sergio, García-Llácer, Carolina, Clemente-León, Miguel, Cardona-Serra, Salvador, Casino, Patricia, Martínez-Gil, Luis, Gaita-Ariño, Alejandro, and Coronado, Eugenio
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Condensed Matter - Mesoscale and Nanoscale Physics ,Quantum Physics - Abstract
In this work we showcase the potential of peptides as versatile scaffolds for quantum computing and molecular spintronics. In particular, we focus on lanthanide-binding tags, which were originally developed in the field of biotechnology for the study of protein structure and dynamics. Firstly, we demonstrate quantum coherent oscillations in a Neodymium peptidic qubit. Then, employing bacterial biosynthesis, we investigate the possibility of increasing the number of qubits in the same molecular system, with the case studies being a double spin qubit with two distinct coordination environments, and an asymmetric chain of 9 spin qubits with a spin-spin separation of about 2 nm and in an arbitrarily chosen sequence of coordination environments. Finally, we take advantage of biochemical modification for the preparation of paramagnetic, chiral, Self-Assembled Monolayers (SAMs) on Au(111).Our experimental and theoretical characterization shows that this is a promising structure for spintronic applications, and in particular to improve on two state-of-the-art approaches to molecular spin qubits. We conclude with an overview of the challenges and new opportunities opened by this emerging field., Comment: Manuscript from LaTeX, Supporting Information as pdf from LibreOffice. Update: minor changes, improved figures
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- 2017
36. Synthesis of Nucleoside Selenophosphoramidates via H‑Phosphonate Intermediates.
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Golebiewska, Justyna, Sobkowski, Michal, and Stawinski, Jacek
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- 2024
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37. Two Sides of Selenium: Occurrence and Determination of Selenium Forms in Food and Environmental Samples Using Analytical Methods
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Zembrzuska, Joanna, Karbowska, Bożena, Gołębiewska, Iwona, Jafari, Seid Mahdi, Series Editor, Jeszka-Skowron, Magdalena, editor, Zgoła-Grześkowiak, Agnieszka, editor, Grześkowiak, Tomasz, editor, and Ramakrishna, Akula, editor
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- 2021
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38. An inclusive Research Education Community (iREC): Impact of the SEA-PHAGES program on research outcomes and student learning
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Hanauer, David I, Graham, Mark J, Betancur, Laura, Bobrownicki, Aiyana, Cresawn, Steven G, Garlena, Rebecca A, Jacobs-Sera, Deborah, Kaufmann, Nancy, Pope, Welkin H, Russell, Daniel A, Jacobs, William R, Sivanathan, Viknesh, Asai, David J, Hatfull, Graham F, Actis, Luis, Adair, Tammy, Adams, Sandra, Alvey, Richard, Anders, Kirk, Anderson, Winston A, Antoniacci, Lisa, Ayuk, Mary, Baliraine, Frederick, Balish, Mitchell, Ball, Sarah, Barbazuk, Brad, Barekzi, Nazir, Barrera, Alessandra, Berkes, Charlotte, Best, Aaron, Bhalla, Suparna, Blumer, Larry, Bollivar, Dave, Bonilla, J Alfred, Borges, Kim, Bortz, Beckie, Breakwell, Donald, Breitenberger, Caroline, Breton, Tim, Brey, Christopher, Bricker, Jerald S, Briggs, Laura, Broderick, Eribo, Brooks, Tessa Durham, Brown-Kennerly, Victoria, Buckholt, Mike, Butela, Kristen, Byrum, Christine, Cain, Donna, Carson, Susan, Caruso, Steve, Caslake, Laurie, Chia, Catherine, Chung, Hui-Min, Clase, Kari, Clement, Barb, Conant, Stephanie, Connors, Bernadette, Coomans, Roy, D'Angelo, William, D'Elia, Tom, Daniels, Charles J, Daniels, Luke, Davis, Bill, DeCourcy, Kristi, DeJong, Randy, Delaney-Nguyen, Kristen, Delesalle, Veronique, Diaz, Arturo, Dickson, Leon, Doty, Jean, Doyle, Erin, Dunbar, David, Easterwood, Jennifer, Eckardt, Megan, Edgington, Nicholas, Elgin, Sarah, Erb, Marcy, Erill, Ivan, Fast, Kayla, Fillman, Christy, Findley, Ann, Fisher, Emily, Fleischacker, Christine, Fogarty, Marie, Frederick, Greg, Frost, Victoria, Furbee, Emily, Gainey, Maria, Gallegos, Isaura, Gissendanner, Chris, Golebiewska, Urszula, Grose, Julianne, Grubb, Sarah, Guild, Nancy, Gurney, Susan, Hartzog, Grant, Hatherill, J Robert, Hauser, Charles, and Hendrickson, Heather
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Quality Education ,Biomedical Research ,Education ,Medical ,Undergraduate ,Female ,Humans ,Learning ,Male ,Program Evaluation ,Teaching ,Universities ,Young Adult ,SEA-PHAGES ,assessment ,bacteriophage ,evolution ,genomics ,science education - Abstract
Engaging undergraduate students in scientific research promises substantial benefits, but it is not accessible to all students and is rarely implemented early in college education, when it will have the greatest impact. An inclusive Research Education Community (iREC) provides a centralized scientific and administrative infrastructure enabling engagement of large numbers of students at different types of institutions. The Science Education Alliance-Phage Hunters Advancing Genomics and Evolutionary Science (SEA-PHAGES) is an iREC that promotes engagement and continued involvement in science among beginning undergraduate students. The SEA-PHAGES students show strong gains correlated with persistence relative to those in traditional laboratory courses regardless of academic, ethnic, gender, and socioeconomic profiles. This persistent involvement in science is reflected in key measures, including project ownership, scientific community values, science identity, and scientific networking.
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- 2017
39. Table S1 from The Epigenetic Evolution of Glioma Is Determined by the IDH1 Mutation Status and Treatment Regimen
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Malta, Tathiane M., primary, Sabedot, Thais S., primary, Morosini, Natalia S., primary, Datta, Indrani, primary, Garofano, Luciano, primary, Vallentgoed, Wies, primary, Varn, Frederick S., primary, Aldape, Kenneth, primary, D'Angelo, Fulvio, primary, Bakas, Spyridon, primary, Barnholtz-Sloan, Jill S., primary, Gan, Hui K., primary, Hasanain, Mohammad, primary, Hau, Ann-Christin, primary, Johnson, Kevin C., primary, Cazacu, Simona, primary, deCarvalho, Ana C., primary, Khasraw, Mustafa, primary, Kocakavuk, Emre, primary, Kouwenhoven, Mathilde C.M., primary, Migliozzi, Simona, primary, Niclou, Simone P., primary, Niers, Johanna M., primary, Ormond, D. Ryan, primary, Paek, Sun Ha, primary, Reifenberger, Guido, primary, Sillevis Smitt, Peter A., primary, Smits, Marion, primary, Stead, Lucy F., primary, van den Bent, Martin J., primary, Van Meir, Erwin G., primary, Walenkamp, Annemiek, primary, Weiss, Tobias, primary, Weller, Michael, primary, Westerman, Bart A., primary, Ylstra, Bauke, primary, Wesseling, Pieter, primary, Lasorella, Anna, primary, French, Pim J., primary, Poisson, Laila M., primary, Woehrer, Adelheid, primary, Lowman, Allison K, primary, deCarvalho, Ana C, primary, Castro, Ana Valeria, primary, Transou, Andrea, primary, Brodbelt, Andrew R, primary, Golebiewska, Anna, primary, Molinaro, Annette M, primary, Iavarone, Antonio, primary, Ismail, Azzam, primary, Westerman, Bart A, primary, Bock, Christoph, primary, Brat, Daniel J, primary, Van Meir, Erwin G, primary, Barthel, Floris P, primary, Varn, Frederick S, primary, Finocchiaro, Gaetano, primary, Rao, Ganesh, primary, Zadeh, Gelareh, primary, ngNg, Ho Keu, primary, Kim, Hoon, primary, Noushmehr, Houtan, primary, Miletic, Hrvoje, primary, Gan, Hui K, primary, Rock, Jack, primary, Snyder, James M, primary, Huse, Jason T, primary, Connelly, Jennifer M, primary, Barnholtz-Sloan, Jill S, primary, Niers, Johanna M, primary, deGroot, John F, primary, Akdemir, Kadir C, primary, Kannan, Kasthuri S, primary, Ligon, Keith L, primary, Bulsara, Ketan R, primary, Johnson, Kevin C, primary, Alfaro, Kristin D, primary, Poisson, Laila M, primary, Stead, Lucy F, primary, Nasrallah, MacLean P, primary, van den Bent, Martin J, primary, Kouwenhoven, Mathilde CM, primary, Gould, Peter V, primary, Smitt, Peter A Sillevis, primary, LaViolette, Peter S, primary, Tatman, Philip D, primary, French, Pim J, primary, Beroukhim, Rameen, primary, Verhaak, Roel G.W., primary, Niclou, Simone P, primary, Kalkanis, Steven, primary, Short, Susan C, primary, Ghazaleh, Tabatabai, primary, Malta, Tathiane M, primary, Sabedot, Thais S, primary, Walbert, Tobias, primary, Baid, Ujjwal, primary, and Yung, W. K. Alfred, primary
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- 2024
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40. Supp Figures from The Epigenetic Evolution of Glioma Is Determined by the IDH1 Mutation Status and Treatment Regimen
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Malta, Tathiane M., primary, Sabedot, Thais S., primary, Morosini, Natalia S., primary, Datta, Indrani, primary, Garofano, Luciano, primary, Vallentgoed, Wies, primary, Varn, Frederick S., primary, Aldape, Kenneth, primary, D'Angelo, Fulvio, primary, Bakas, Spyridon, primary, Barnholtz-Sloan, Jill S., primary, Gan, Hui K., primary, Hasanain, Mohammad, primary, Hau, Ann-Christin, primary, Johnson, Kevin C., primary, Cazacu, Simona, primary, deCarvalho, Ana C., primary, Khasraw, Mustafa, primary, Kocakavuk, Emre, primary, Kouwenhoven, Mathilde C.M., primary, Migliozzi, Simona, primary, Niclou, Simone P., primary, Niers, Johanna M., primary, Ormond, D. Ryan, primary, Paek, Sun Ha, primary, Reifenberger, Guido, primary, Sillevis Smitt, Peter A., primary, Smits, Marion, primary, Stead, Lucy F., primary, van den Bent, Martin J., primary, Van Meir, Erwin G., primary, Walenkamp, Annemiek, primary, Weiss, Tobias, primary, Weller, Michael, primary, Westerman, Bart A., primary, Ylstra, Bauke, primary, Wesseling, Pieter, primary, Lasorella, Anna, primary, French, Pim J., primary, Poisson, Laila M., primary, Woehrer, Adelheid, primary, Lowman, Allison K, primary, deCarvalho, Ana C, primary, Castro, Ana Valeria, primary, Transou, Andrea, primary, Brodbelt, Andrew R, primary, Golebiewska, Anna, primary, Molinaro, Annette M, primary, Iavarone, Antonio, primary, Ismail, Azzam, primary, Westerman, Bart A, primary, Bock, Christoph, primary, Brat, Daniel J, primary, Van Meir, Erwin G, primary, Barthel, Floris P, primary, Varn, Frederick S, primary, Finocchiaro, Gaetano, primary, Rao, Ganesh, primary, Zadeh, Gelareh, primary, ngNg, Ho Keu, primary, Kim, Hoon, primary, Noushmehr, Houtan, primary, Miletic, Hrvoje, primary, Gan, Hui K, primary, Rock, Jack, primary, Snyder, James M, primary, Huse, Jason T, primary, Connelly, Jennifer M, primary, Barnholtz-Sloan, Jill S, primary, Niers, Johanna M, primary, deGroot, John F, primary, Akdemir, Kadir C, primary, Kannan, Kasthuri S, primary, Ligon, Keith L, primary, Bulsara, Ketan R, primary, Johnson, Kevin C, primary, Alfaro, Kristin D, primary, Poisson, Laila M, primary, Stead, Lucy F, primary, Nasrallah, MacLean P, primary, van den Bent, Martin J, primary, Kouwenhoven, Mathilde CM, primary, Gould, Peter V, primary, Smitt, Peter A Sillevis, primary, LaViolette, Peter S, primary, Tatman, Philip D, primary, French, Pim J, primary, Beroukhim, Rameen, primary, Verhaak, Roel G.W., primary, Niclou, Simone P, primary, Kalkanis, Steven, primary, Short, Susan C, primary, Ghazaleh, Tabatabai, primary, Malta, Tathiane M, primary, Sabedot, Thais S, primary, Walbert, Tobias, primary, Baid, Ujjwal, primary, and Yung, W. K. Alfred, primary
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- 2024
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41. Supplemental Figures Legends from The Epigenetic Evolution of Glioma Is Determined by the IDH1 Mutation Status and Treatment Regimen
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Malta, Tathiane M., primary, Sabedot, Thais S., primary, Morosini, Natalia S., primary, Datta, Indrani, primary, Garofano, Luciano, primary, Vallentgoed, Wies, primary, Varn, Frederick S., primary, Aldape, Kenneth, primary, D'Angelo, Fulvio, primary, Bakas, Spyridon, primary, Barnholtz-Sloan, Jill S., primary, Gan, Hui K., primary, Hasanain, Mohammad, primary, Hau, Ann-Christin, primary, Johnson, Kevin C., primary, Cazacu, Simona, primary, deCarvalho, Ana C., primary, Khasraw, Mustafa, primary, Kocakavuk, Emre, primary, Kouwenhoven, Mathilde C.M., primary, Migliozzi, Simona, primary, Niclou, Simone P., primary, Niers, Johanna M., primary, Ormond, D. Ryan, primary, Paek, Sun Ha, primary, Reifenberger, Guido, primary, Sillevis Smitt, Peter A., primary, Smits, Marion, primary, Stead, Lucy F., primary, van den Bent, Martin J., primary, Van Meir, Erwin G., primary, Walenkamp, Annemiek, primary, Weiss, Tobias, primary, Weller, Michael, primary, Westerman, Bart A., primary, Ylstra, Bauke, primary, Wesseling, Pieter, primary, Lasorella, Anna, primary, French, Pim J., primary, Poisson, Laila M., primary, Woehrer, Adelheid, primary, Lowman, Allison K, primary, deCarvalho, Ana C, primary, Castro, Ana Valeria, primary, Transou, Andrea, primary, Brodbelt, Andrew R, primary, Golebiewska, Anna, primary, Molinaro, Annette M, primary, Iavarone, Antonio, primary, Ismail, Azzam, primary, Westerman, Bart A, primary, Bock, Christoph, primary, Brat, Daniel J, primary, Van Meir, Erwin G, primary, Barthel, Floris P, primary, Varn, Frederick S, primary, Finocchiaro, Gaetano, primary, Rao, Ganesh, primary, Zadeh, Gelareh, primary, ngNg, Ho Keu, primary, Kim, Hoon, primary, Noushmehr, Houtan, primary, Miletic, Hrvoje, primary, Gan, Hui K, primary, Rock, Jack, primary, Snyder, James M, primary, Huse, Jason T, primary, Connelly, Jennifer M, primary, Barnholtz-Sloan, Jill S, primary, Niers, Johanna M, primary, deGroot, John F, primary, Akdemir, Kadir C, primary, Kannan, Kasthuri S, primary, Ligon, Keith L, primary, Bulsara, Ketan R, primary, Johnson, Kevin C, primary, Alfaro, Kristin D, primary, Poisson, Laila M, primary, Stead, Lucy F, primary, Nasrallah, MacLean P, primary, van den Bent, Martin J, primary, Kouwenhoven, Mathilde CM, primary, Gould, Peter V, primary, Smitt, Peter A Sillevis, primary, LaViolette, Peter S, primary, Tatman, Philip D, primary, French, Pim J, primary, Beroukhim, Rameen, primary, Verhaak, Roel G.W., primary, Niclou, Simone P, primary, Kalkanis, Steven, primary, Short, Susan C, primary, Ghazaleh, Tabatabai, primary, Malta, Tathiane M, primary, Sabedot, Thais S, primary, Walbert, Tobias, primary, Baid, Ujjwal, primary, and Yung, W. K. Alfred, primary
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- 2024
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42. Data from The Epigenetic Evolution of Glioma Is Determined by the IDH1 Mutation Status and Treatment Regimen
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Malta, Tathiane M., primary, Sabedot, Thais S., primary, Morosini, Natalia S., primary, Datta, Indrani, primary, Garofano, Luciano, primary, Vallentgoed, Wies, primary, Varn, Frederick S., primary, Aldape, Kenneth, primary, D'Angelo, Fulvio, primary, Bakas, Spyridon, primary, Barnholtz-Sloan, Jill S., primary, Gan, Hui K., primary, Hasanain, Mohammad, primary, Hau, Ann-Christin, primary, Johnson, Kevin C., primary, Cazacu, Simona, primary, deCarvalho, Ana C., primary, Khasraw, Mustafa, primary, Kocakavuk, Emre, primary, Kouwenhoven, Mathilde C.M., primary, Migliozzi, Simona, primary, Niclou, Simone P., primary, Niers, Johanna M., primary, Ormond, D. Ryan, primary, Paek, Sun Ha, primary, Reifenberger, Guido, primary, Sillevis Smitt, Peter A., primary, Smits, Marion, primary, Stead, Lucy F., primary, van den Bent, Martin J., primary, Van Meir, Erwin G., primary, Walenkamp, Annemiek, primary, Weiss, Tobias, primary, Weller, Michael, primary, Westerman, Bart A., primary, Ylstra, Bauke, primary, Wesseling, Pieter, primary, Lasorella, Anna, primary, French, Pim J., primary, Poisson, Laila M., primary, Woehrer, Adelheid, primary, Lowman, Allison K, primary, deCarvalho, Ana C, primary, Castro, Ana Valeria, primary, Transou, Andrea, primary, Brodbelt, Andrew R, primary, Golebiewska, Anna, primary, Molinaro, Annette M, primary, Iavarone, Antonio, primary, Ismail, Azzam, primary, Westerman, Bart A, primary, Bock, Christoph, primary, Brat, Daniel J, primary, Van Meir, Erwin G, primary, Barthel, Floris P, primary, Varn, Frederick S, primary, Finocchiaro, Gaetano, primary, Rao, Ganesh, primary, Zadeh, Gelareh, primary, ngNg, Ho Keu, primary, Kim, Hoon, primary, Noushmehr, Houtan, primary, Miletic, Hrvoje, primary, Gan, Hui K, primary, Rock, Jack, primary, Snyder, James M, primary, Huse, Jason T, primary, Connelly, Jennifer M, primary, Barnholtz-Sloan, Jill S, primary, Niers, Johanna M, primary, deGroot, John F, primary, Akdemir, Kadir C, primary, Kannan, Kasthuri S, primary, Ligon, Keith L, primary, Bulsara, Ketan R, primary, Johnson, Kevin C, primary, Alfaro, Kristin D, primary, Poisson, Laila M, primary, Stead, Lucy F, primary, Nasrallah, MacLean P, primary, van den Bent, Martin J, primary, Kouwenhoven, Mathilde CM, primary, Gould, Peter V, primary, Smitt, Peter A Sillevis, primary, LaViolette, Peter S, primary, Tatman, Philip D, primary, French, Pim J, primary, Beroukhim, Rameen, primary, Verhaak, Roel G.W., primary, Niclou, Simone P, primary, Kalkanis, Steven, primary, Short, Susan C, primary, Ghazaleh, Tabatabai, primary, Malta, Tathiane M, primary, Sabedot, Thais S, primary, Walbert, Tobias, primary, Baid, Ujjwal, primary, and Yung, W. K. Alfred, primary
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- 2024
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43. Supplementary Appendix from The Epigenetic Evolution of Glioma Is Determined by the IDH1 Mutation Status and Treatment Regimen
- Author
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Malta, Tathiane M., primary, Sabedot, Thais S., primary, Morosini, Natalia S., primary, Datta, Indrani, primary, Garofano, Luciano, primary, Vallentgoed, Wies, primary, Varn, Frederick S., primary, Aldape, Kenneth, primary, D'Angelo, Fulvio, primary, Bakas, Spyridon, primary, Barnholtz-Sloan, Jill S., primary, Gan, Hui K., primary, Hasanain, Mohammad, primary, Hau, Ann-Christin, primary, Johnson, Kevin C., primary, Cazacu, Simona, primary, deCarvalho, Ana C., primary, Khasraw, Mustafa, primary, Kocakavuk, Emre, primary, Kouwenhoven, Mathilde C.M., primary, Migliozzi, Simona, primary, Niclou, Simone P., primary, Niers, Johanna M., primary, Ormond, D. Ryan, primary, Paek, Sun Ha, primary, Reifenberger, Guido, primary, Sillevis Smitt, Peter A., primary, Smits, Marion, primary, Stead, Lucy F., primary, van den Bent, Martin J., primary, Van Meir, Erwin G., primary, Walenkamp, Annemiek, primary, Weiss, Tobias, primary, Weller, Michael, primary, Westerman, Bart A., primary, Ylstra, Bauke, primary, Wesseling, Pieter, primary, Lasorella, Anna, primary, French, Pim J., primary, Poisson, Laila M., primary, Woehrer, Adelheid, primary, Lowman, Allison K, primary, deCarvalho, Ana C, primary, Castro, Ana Valeria, primary, Transou, Andrea, primary, Brodbelt, Andrew R, primary, Golebiewska, Anna, primary, Molinaro, Annette M, primary, Iavarone, Antonio, primary, Ismail, Azzam, primary, Westerman, Bart A, primary, Bock, Christoph, primary, Brat, Daniel J, primary, Van Meir, Erwin G, primary, Barthel, Floris P, primary, Varn, Frederick S, primary, Finocchiaro, Gaetano, primary, Rao, Ganesh, primary, Zadeh, Gelareh, primary, ngNg, Ho Keu, primary, Kim, Hoon, primary, Noushmehr, Houtan, primary, Miletic, Hrvoje, primary, Gan, Hui K, primary, Rock, Jack, primary, Snyder, James M, primary, Huse, Jason T, primary, Connelly, Jennifer M, primary, Barnholtz-Sloan, Jill S, primary, Niers, Johanna M, primary, deGroot, John F, primary, Akdemir, Kadir C, primary, Kannan, Kasthuri S, primary, Ligon, Keith L, primary, Bulsara, Ketan R, primary, Johnson, Kevin C, primary, Alfaro, Kristin D, primary, Poisson, Laila M, primary, Stead, Lucy F, primary, Nasrallah, MacLean P, primary, van den Bent, Martin J, primary, Kouwenhoven, Mathilde CM, primary, Gould, Peter V, primary, Smitt, Peter A Sillevis, primary, LaViolette, Peter S, primary, Tatman, Philip D, primary, French, Pim J, primary, Beroukhim, Rameen, primary, Verhaak, Roel G.W., primary, Niclou, Simone P, primary, Kalkanis, Steven, primary, Short, Susan C, primary, Ghazaleh, Tabatabai, primary, Malta, Tathiane M, primary, Sabedot, Thais S, primary, Walbert, Tobias, primary, Baid, Ujjwal, primary, and Yung, W. K. Alfred, primary
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- 2024
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44. G4-Ligand-Conjugated Oligonucleotides Mediate Selective Binding and Stabilization of Individual G4 DNA Structures
- Author
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Berner, Andreas, primary, Das, Rabindra Nath, additional, Bhuma, Naresh, additional, Golebiewska, Justyna, additional, Abrahamsson, Alva, additional, Andréasson, Måns, additional, Chaudhari, Namrata, additional, Doimo, Mara, additional, Bose, Partha Pratim, additional, Chand, Karam, additional, Strömberg, Roger, additional, Wanrooij, Sjoerd, additional, and Chorell, Erik, additional
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- 2024
- Full Text
- View/download PDF
45. Oncolytic H-1 parvovirus binds to sialic acid on laminins for cell attachment and entry
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Amit Kulkarni, Tiago Ferreira, Clemens Bretscher, Annabel Grewenig, Nazim El-Andaloussi, Serena Bonifati, Tiina Marttila, Valérie Palissot, Jubayer A. Hossain, Francisco Azuaje, Hrvoje Miletic, Lars A. R. Ystaas, Anna Golebiewska, Simone P. Niclou, Ralf Roeth, Beate Niesler, Amélie Weiss, Laurent Brino, and Antonio Marchini
- Subjects
Science - Abstract
Rat H-1 parvovirus (H-1PV) is in clinical development for oncolytic therapy. Here, Kulkarni et al. identify LAMC1 as a modulator of H-1PV cell attachment and entry and find that LAMC1 levels and H-1PV oncolytic activity correlate in 59 tested cancer cell lines.
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- 2021
- Full Text
- View/download PDF
46. Case study of pilot’s Heart Rate Variability (HRV) during flight operation
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Maciejewska, Marta and Galant-Gołębiewska, Marta
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- 2021
- Full Text
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47. Measuring regional diversification of environmental externalities in agriculture and the effectiveness of their reduction by EU agri-environmental programs in Poland
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Pajewski, Tomasz, Malak-Rawlikowska, Agata, and Gołębiewska, Barbara
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- 2020
- Full Text
- View/download PDF
48. New hints towards a precision medicine strategy for IDH wild-type glioblastoma
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White, K., Connor, K., Clerkin, J., Murphy, B.M., Salvucci, M., O'Farrell, A.C., Rehm, M., O'Brien, D., Prehn, J.H.M., Niclou, S.P., Lamfers, M.L.M., Verreault, M., Idbaih, A., Verhaak, R., Golebiewska, A., and Byrne, A.T.
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- 2020
- Full Text
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49. Leading Behavioral Characteristics and Investors’ Decisions: An Experimental Approach
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Blajer-Gołębiewska, Anna, Czerwonka, Leszek, Kozłowski, Arkadiusz, and Strielkowski, Wadim, editor
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- 2019
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50. A rare large duplication of MLH1 identified in Lynch syndrome
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Abhishek Kumar, Nagarajan Paramasivam, Obul Reddy Bandapalli, Matthias Schlesner, Tianhui Chen, Rolf Sijmons, Dagmara Dymerska, Katarzyna Golebiewska, Magdalena Kuswik, Jan Lubinski, Kari Hemminki, and Asta Försti
- Subjects
Genetic predisposition ,Lynch syndrome ,Mismatch repair genes ,Whole-genome sequencing ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 ,Genetics ,QH426-470 - Abstract
Abstract Background The most frequently identified strong cancer predisposition mutations for colorectal cancer (CRC) are those in the mismatch repair (MMR) genes in Lynch syndrome. Laboratory diagnostics include testing tumors for immunohistochemical staining (IHC) of the Lynch syndrome-associated DNA MMR proteins and/or for microsatellite instability (MSI) followed by sequencing or other techniques, such as denaturing high performance liquid chromatography (DHPLC), to identify the mutation. Methods In an ongoing project focusing on finding Mendelian cancer syndromes we applied whole-exome/whole-genome sequencing (WES/WGS) to 19 CRC families. Results Three families were identified with a pathogenic/likely pathogenic germline variant in a MMR gene that had previously tested negative in DHPLC gene variant screening. All families had a history of CRC in several family members across multiple generations. Tumor analysis showed loss of the MMR protein IHC staining corresponding to the mutated genes, as well as MSI. In family A, a structural variant, a duplication of exons 4 to 13, was identified in MLH1. The duplication was predicted to lead to a frameshift at amino acid 520 and a premature stop codon at amino acid 539. In family B, a 1 base pair deletion was found in MLH1, resulting in a frameshift and a stop codon at amino acid 491. In family C, we identified a splice site variant in MSH2, which was predicted to lead loss of a splice donor site. Conclusions We identified altogether three pathogenic/likely pathogenic variants in the MMR genes in three of the 19 sequenced families. The MLH1 variants, a duplication of exons 4 to 13 and a frameshift variant, were novel, based on the InSiGHT and ClinVar databases; the MSH2 splice site variant was reported by a single submitter in ClinVar. As a variant class, duplications have rarely been reported in the MMR gene literature, particularly those covering several exons.
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- 2021
- Full Text
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