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4. Perioperative and long-term oncological outcomes after local tumor ablation for complex (PADUA Score =10) cT1a renal tumors: a multicenter analysis

Author

Piazza, P., primary, Bianchi, L., additional, Luzzago, S., additional, Bandini, M., additional, Mottaran, A., additional, Amirhassankhani, S., additional, De Concilio, B., additional, Celia, A., additional, Serra, C., additional, Cappelli, A., additional, Golfieri, R., additional, Musi, G., additional, Gallina, A., additional, Rizzo, M., additional, Liguori, G., additional, Trombetta, C., additional, De Cobelli, F., additional, Mauri, G., additional, Orsi, F., additional, Capitanio, U., additional, Schiavina, R., additional, De Cobelli, O., additional, Montorsi, F., additional, and Brunocilla, E., additional

Published
2023
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5. Proposal and internal validation of a nomogram for the prediction of local recurrence-free survival after percutaneous ablation for ct1 renal masses

Author

Mottaran, A., primary, Nocera, L., additional, Bianchi, L., additional, Luzzago, S., additional, Bandini, M., additional, Piazza, P., additional, Celia, A., additional, Serra, C., additional, Cappelli, A., additional, De Cinque, A., additional, Modestino, F., additional, Golfieri, R., additional, Musi, G., additional, Gallina, A., additional, De Cobelli, F., additional, Mauri, G., additional, Orsi, F., additional, Capitanio, U., additional, Schiavina, R., additional, De Cobelli, O., additional, Montorsi, F., additional, and Brunocilla, E., additional

Published
2023
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9. PD-0566 MRI before salvage radiotherapy after radical prostatectomy in prostate cancer: a case-control study

Author

Cavallini, L., primary, Gaudiano, C., additional, Galietta, E., additional, Mammini, F., additional, Paolinelli, S., additional, Laghi, V., additional, Vallerossa, D., additional, Natoli, E., additional, Morganti, A.G., additional, Arcelli, A., additional, Cammelli, S., additional, Macchia, G., additional, Deodato, F., additional, Golfieri, R., additional, Frezza, G.P., additional, and Ntreta, M., additional

Published
2023
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11. Beyond multiparametric MRI and towards radiomics to detect prostate cancer: A machine learning model to predict clinically significant lesions

Author

Bianchi, L., primary, Gaudiano, C., additional, Mottola, M., additional, Corcioni, B., additional, Tonin, E., additional, Droghetti, M., additional, Cattabriga, A., additional, Cocozza, M.A., additional, Palmeri, A., additional, Coppola, F., additional, Giunchi, F., additional, Schiavina, R., additional, Fiorentino, M., additional, Brunocilla, E., additional, Golfieri, R., additional, and Bevilacqua, A., additional

Published
2023
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12. 3D-derived volumetric and morphologic parameters to predict complications after robotic partial nephrectomy in patients with renal cancer

Author

Bianchi, L., primary, Bortolani, B., additional, Cercenelli, L., additional, Presutti, M., additional, Mottaran, A., additional, Boschi, S., additional, Spinozzi, L., additional, Melloni, R., additional, Scarlatti, R., additional, Pissavini, A., additional, Amirhassankhani, S., additional, Droghetti, M., additional, Gaudiano, C., additional, Rustici, A., additional, Tartarini, L., additional, Golfieri, R., additional, Marcelli, E., additional, Schiavina, R., additional, and Brunocilla, E., additional

Published
2023
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13. The impact of 3D modeling in surgical planning and outcomes of partial nephrectomy

Author

Droghetti, M., primary, Bortolani, B., additional, Cercenelli, L., additional, Piazza, P., additional, Boschi, S., additional, Mottaran, A., additional, Chessa, F., additional, Ercolino, A., additional, Angiolini, A., additional, Lodi, S., additional, Pissavini, A., additional, Fontanella, L., additional, Spinozzi, L., additional, Melloni, R., additional, Bevilacqua, F., additional, Cangemi, D., additional, Gaudiano, C., additional, Corcioni, B., additional, Golfieri, R., additional, Marcelli, E., additional, Bianchi, L., additional, Schiavina, R., additional, and Brunocilla, E., additional

Published
2022
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14. PERC-score as a nephrometry scoring system in percutaneous tumour ablation: Comparison with RENAL, mRENAL, PADUA and SPARE in a multi-centre series

Author

Piazza, P., primary, Bianchi, L., additional, Luzzago, S., additional, Bandini, M., additional, Amirhassankhani, S., additional, Droghetti, M., additional, Celia, A., additional, Serra, C., additional, Cappelli, A., additional, De Cinque, A., additional, Modestino, F., additional, Golfieri, R., additional, Musi, G., additional, Gallina, A., additional, De Cobelli, F., additional, Mauri, G., additional, Orsi, F., additional, Capitanio, U., additional, Schiavina, R., additional, De Cobelli, O., additional, Montorsi, F., additional, and Brunocilla, E., additional

Published
2022
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15. The impact of histology and type of energy used on oncological outcomes after local tumor ablation of small renal masses

Author

Piazza, P., primary, Bianchi, L., additional, Luzzago, S., additional, Bandini, M., additional, Mottaran, A., additional, Amirhassankhani, S., additional, Puliatti, S., additional, De Concilio, B., additional, Celia, A., additional, Serra, C., additional, Cappelli, A., additional, Modestino, F., additional, De Cinque, A., additional, Golfieri, R., additional, Musi, G., additional, Lugano, A., additional, De Cobelli, F., additional, Mauri, G., additional, Orsi, F., additional, Capitanio, U., additional, Schiavina, R., additional, De Cobelli, O., additional, Montorsi, F., additional, and Brunocilla, E., additional

Published
2022
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16. 3D virtual models for planning percutaneous Cryoablation of small renal masses

Author

Bianchi, L., primary, Spinozzi, L., additional, Mottaran, A., additional, Roveroni, C., additional, Cercenelli, L., additional, Bortolani, B., additional, Cappelli, A., additional, Modestino, F., additional, Piazza, P., additional, Droghetti, M., additional, Fontanella, L., additional, Cangemi, D., additional, Gaudiano, C., additional, Carpani, G., additional, De Cinque, A., additional, Scarlatti, R., additional, Manes, F., additional, Casadei, F., additional, Chessa, F., additional, Marcelli, E., additional, Golfieri, R., additional, Schiavina, R., additional, and Brunocilla, E., additional

Published
2022
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17. Radiologically defined lipid-poor adrenal adenomas: histopathological characteristics

Author

De Leo, A., Mosconi, C., Zavatta, G., Tucci, L., Nanni, C., Selva, S., Balacchi, C., Ceccarelli, C., Santini, D., Pantaleo, M. A., Minni, F., Fanti, S., Golfieri, R., Pagotto, U., Vicennati, V., and Di Dalmazi, G.

Abstract

Background: Adrenal lipid-poor adenomas (LPA) are defined by high unenhanced density (≥ 10 HU), and absolute and relative contrast medium washout > 60% and > 40%, respectively, at computerized tomography (CT). To date, no thorough histopathological characterization has been performed in those frequent lesions (one-third of adrenal adenomas). Our aim was to analyze the histopathological characteristics of adrenal LPA. Methods: Patients with LPA (n= 57) were selected among consecutive subjects referred for an adrenal incidentaloma or ACTH-independent Cushing syndrome. FluoroDeoxyGlucose-Positron Emission Tomography (FDG-PET) was performed in 37 patients. In patients treated by adrenalectomy (n= 17), Weiss score and Lin–Weiss–Bisceglia score (in tumors composed entirely or predominantly of oncocytes) were calculated. Results: Radiological parameters did not differ among patients with ACTH-independent Cushing syndrome (n= 6) and those with adrenal incidentalomas associated with primary aldosteronism (n= 2), autonomous cortisol secretion (n= 14), or non-functioning (n= 35). Patients treated by adrenalectomy had larger tumors (28.9 ± 11.2 vs17.3 ± 8.4 mm,P< 0.001), higher CT unenhanced density (29.1 ± 11.0 vs23.1 ± 9.0 HU, P= 0.043), and FDG-PET adrenal uptake (9.0 ± 6.4 vs4.4 ± 2.3 SUV, P= 0.003) than non-operated ones. Oncocytic features > 75% of the tumor were detected in 12/17 cases (70.6%). Five of those showed borderline-malignant histopathological characteristics by Lin–Weiss–Bisceglia score. Among remaining non-oncocytic tumors, 1/5 had a Weiss score ≥ 3. Overall, 6/17 tumors (35.3%) had borderline-malignant potential. Radiological parameters were similar between patients with benign and borderline-malignant tumors. Conclusions: Adrenal LPA are a heterogeneous group of tumors, mostly composed of oncocytomas. Up to 1/3 of those tumors may have a borderline-malignant potential at histopathology.

Published
2024
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18. Pattern of macrovascular invasion in hepatocellular carcinoma

Author

Guarino, M., Cucchetti, A., Pontillo, G., Farinati, F., Benevento, F., Rapaccini, G. L., Di Marco, M., Caturelli, E., Zoli, M., Rodolfo, S., Cabibbo, G., Marra, F., Mega, A., Gasbarrini, A., Svegliati-Baroni, G., Foschi, F. G., Missale, G., Masotto, A., Nardone, G., Raimondo, G., Azzaroli, F., Vidili, G., Oliveri, F., Trevisani, F., Giannini, E. G., Morisco, F., Biselli, M., Caraceni, P., Garuti, F., Gramenzi, A., Neri, A., Rampoldi, D., Santi, V., Forgione, A., Granito, A., Muratori, L., Piscaglia, F., Sansone, V., Tovoli, F., Dajti, E., Marasco, G., Ravaioli, F., Cappelli, A., Golfieri, R., Mosconi, C., Renzulli, M., Cela, E. M., Facciorusso, A., Pelizzaro, F., Imondi, A., Sartori, A., Penzo, B., Cacciato, V., Casagrande, E., Moscatelli, A., Pellegatta, G., Pieri, G., de Matthaeis, N., Allegrini, G., Lauria, V., Ghittoni, G., Pelecca, G., Chegai, F., Coratella, F., Ortenzi, M., Olivari, A., Inno, A., Marchetti, F., Busacca, A., Camma, C., Di Martino, V., Rizzo, G. E. M., Franze, M. S., Saitta, C., Sauchella, A., Bevilacqua, V., Borghi, A., Gardini, A. C., Conti, F., Berardinelli, D., Ercolani, G., Napoli, L., Campani, C., Di Bonaventura, C., Gitto, S., Coccoli, P., Malerba, A., Capasso, M., Fiorentino, A., Pignata, L., Cossiga, V., Romagnoli, V., Guarino M., Cucchetti A., Pontillo G., Farinati F., Benevento F., Rapaccini G.L., Di Marco M., Caturelli E., Zoli M., Rodolfo S., Cabibbo G., Marra F., Mega A., Gasbarrini A., Svegliati-Baroni G., Foschi F.G., Missale G., Masotto A., Nardone G., Raimondo G., Azzaroli F., Vidili G., Oliveri F., Trevisani F., Giannini E.G., Morisco F., Biselli M., Caraceni P., Garuti F., Gramenzi A., Neri A., Rampoldi D., Santi V., Forgione A., Granito A., Muratori L., Piscaglia F., Sansone V., Tovoli F., Dajti E., Marasco G., Ravaioli F., Cappelli A., Golfieri R., Mosconi C., Renzulli M., Cela E.M., Facciorusso A., Pelizzaro F., Imondi A., Sartori A., Penzo B., Cacciato V., Casagrande E., Moscatelli A., Pellegatta G., Pieri G., de Matthaeis N., Allegrini G., Lauria V., Ghittoni G., Pelecca G., Chegai F., Coratella F., Ortenzi M., Olivari A., Inno A., Marchetti F., Busacca A., Camma C., Di Martino V., Rizzo G.E.M., Franze M.S., Saitta C., Sauchella A., Bevilacqua V., Borghi A., Gardini A.C., Conti F., Berardinelli D., Ercolani G., Napoli L., Campani C., Di Bonaventura C., Gitto S., Coccoli P., Malerba A., Capasso M., Fiorentino A., Pignata L., Cossiga V., Romagnoli V., Guarino, M., Cucchetti, A., Pontillo, G., Farinati, F., Benevento, F., Rapaccini, G. L., Di Marco, M., Caturelli, E., Zoli, M., Rodolfo, S., Cabibbo, G., Marra, F., Mega, A., Gasbarrini, A., Svegliati-Baroni, G., Foschi, F. G., Missale, G., Masotto, A., Nardone, G., Raimondo, G., Azzaroli, F., Vidili, G., Oliveri, F., Trevisani, F., Giannini, E. G., Morisco, F., Biselli, M., Caraceni, P., Garuti, F., Gramenzi, A., Neri, A., Rampoldi, D., Santi, V., Forgione, A., Granito, A., Muratori, L., Piscaglia, F., Sansone, V., Tovoli, F., Dajti, E., Marasco, G., Ravaioli, F., Cappelli, A., Golfieri, R., Mosconi, C., Renzulli, M., Cela, E. M., Facciorusso, A., Pelizzaro, F., Imondi, A., Sartori, A., Penzo, B., Cacciato, V., Casagrande, E., Moscatelli, A., Pellegatta, G., Pieri, G., de Matthaeis, N., Allegrini, G., Lauria, V., Ghittoni, G., Pelecca, G., Chegai, F., Coratella, F., Ortenzi, M., Olivari, A., Inno, A., Marchetti, F., Busacca, A., Camma, C., Di Martino, V., Rizzo, G. E. M., Franze, M. S., Saitta, C., Sauchella, A., Bevilacqua, V., Borghi, A., Gardini, A. C., Conti, F., Berardinelli, D., Ercolani, G., Napoli, L., Campani, C., Di Bonaventura, C., Gitto, S., Coccoli, P., Malerba, A., Capasso, M., Fiorentino, A., Pignata, L., Cossiga, V., and Romagnoli, V.

Subjects
Ablation Techniques, Male, Registrie, Cirrhosis, Clinical Biochemistry, Mesenteric Vein, loco-regional treatment, 030204 cardiovascular system & hematology, Biochemistry, Gastroenterology, surgery, Antineoplastic Agent, Liver disease, 0302 clinical medicine, Non-alcoholic Fatty Liver Disease, cirrhosis, hepatocellular carcinoma, portal vein thrombosis, transplantation, Ascites, Ablation Technique, Registries, 030212 general & internal medicine, Chronic, Settore MED/12 - Gastroenterologia, Portal Vein, Liver Diseases, Liver Neoplasms, General Medicine, Middle Aged, Sorafenib, Prognosis, Hepatitis B, Alcoholic, Hepatitis C, Tumor Burden, Survival Rate, Italy, Liver Neoplasm, Hepatocellular carcinoma, Ascite, Female, medicine.symptom, Liver cancer, Human, medicine.medical_specialty, Carcinoma, Hepatocellular, Prognosi, Antineoplastic Agents, End Stage Liver Disease, 03 medical and health sciences, Mesenteric Veins, Hepatitis B, Chronic, Internal medicine, medicine, Humans, Hepatectomy, Neoplasm Invasiveness, portal vein thrombosi, Liver Diseases, Alcoholic, Aged, Neoplasm Invasivene, Performance status, business.industry, Carcinoma, Settore MED/09 - MEDICINA INTERNA, Patient Acuity, Hepatocellular, Hepatitis C, Chronic, medicine.disease, Liver Transplantation, Transplantation, Liver function, business, cirrhosi
Abstract

Background and aims: In patients with hepatocellular carcinoma (HCC), macrovascular invasion (MaVI) limits treatment options and decreases survival. Detailed data on the relationship between MaVI extension and patients' characteristics, and its impact on patients' outcome are limited. We evaluated the prevalence and extension of MaVI in a large cohort of consecutive HCC patients, analysing its association with liver disease and tumour characteristics, as well as with treatments performed and patients' survival. Methods: We analysed data of 4774 patients diagnosed with HCC recorded in the Italian Liver Cancer (ITA.LI.CA) database (2008-2018). Recursive partition analysis (RPA) was performed to evaluate interactions between MaVI, clinical variables and treatment, exploring the inter-relationship determining overall survival. Results: MaVI prevalence was 11.1%, and median survival of these patients was 6.0months (95% CI, 5.1-7.1). MaVI was associated with younger age at diagnosis, presence of symptoms, worse Performance Status (PS) and liver function, high alphafetoprotein levels and large HCCs. MaVI extension was associated with worse PS, ascites and greater impairment in liver function. RPA identified patients' categories with different treatment indications and survival, ranging from 2.4months in those with PS>1 and ascites, regardless of MaVI extension (receiving best supportive care in 90.3% of cases), to 14.1months in patients with PS 0-1, no ascites and Vp1-Vp2 MaVI (treated with surgery in 19.1% of cases). Conclusions: MaVI presence and extension, together with PS and ascites, significantly affect patients' survival and treatment selection. The decision tree based on these parameters may help assess patients' prognosis and inform therapeutic decisions.

Published
2021
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19. Transarterial radioembolization using yttrium-90 microspheres in the treatment of hepatocellular carcinoma: a review on clinical utility and developments

Author

Cappelli A, Pettinato C, and Golfieri R

Subjects
Radioembolization, Yttrium-90, Hepatocellular carcinoma, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Alberta Cappelli,1 Cinzia Pettinato,2 Rita Golfieri1 1Radiology Unit, 2Medical Physics Unit, Department of Medical and Surgical Sciences, Alma Mater Studiorum – University of Bologna, S Orsola-Malpighi Hospital, Bologna, Italy Abstract: A selective intra-arterial liver injection using yttrium-90-loaded microspheres as sources for internal radiation therapy is a form of transarterial radioembolization (TARE). Current data from the literature suggest that TARE is effective in hepatocellular carcinoma (HCC) and is associated with a low rate of adverse events; however, they are all based on retrospective series or non-controlled prospective studies, since randomized controlled trials comparing the other liver-directed therapies for intermediate and locally advanced stages HCC are still ongoing. The available data show that TARE provides similar or even better survival rates. TARE is very well tolerated and has a low rate of complications; these complications do not result from the embolic effects but mainly from the unintended irradiation to non-target tissue, including the liver parenchyma. The complications can be further reduced by accurate patient selection and a strict pre-treatment evaluation, including dosimetry and assessment of the vascular anatomy. First-line TARE is best indicated for intermediate-stage patients (according to the Barcelona Clinic Liver Cancer [BCLC] staging classification) who are poor candidates for transarterial chemoembolization or patients having locally advanced disease with segmental or lobar branch portal vein thrombosis. Moreover, data are emerging regarding the use of TARE in patients classified slightly above the criteria for liver transplantation with the purpose of downstaging them. TARE can also be applied as a second-line treatment in patients progressing to transarterial chemoembolization or sorafenib; a large number of Phase II/III trials are in progress in order to evaluate the best association with systemic therapies. Given the complexity of a correct treatment algorithm for potential TARE candidates and the need for clinical guidance, a comprehensive review was carried out analyzing both the best selection criteria of patients who really benefit from TARE and the new advances of this therapy which add significant value to the therapeutic weaponry against HCC. Keywords: radioembolization, yttrium-90, hepatocellular carcinoma

Published
2014

20. Inter-center agreement of mRECIST in transplanted patients for hepatocellular carcinoma

Author

Vicentin, I, Mosconi, C, Garanzini, E, Sposito, C, Serenari, M, Buscemi, V, Verna, M, Spreafico, C, Golfieri, R, Mazzaferro, V, De Carlis, L, Cescon, M, Ercolani, G, Vanzulli, A, Cucchetti, A, Vicentin I., Mosconi C., Garanzini E., Sposito C., Serenari M., Buscemi V., Verna M., Spreafico C., Golfieri R., Mazzaferro V., De Carlis L., Cescon M., Ercolani G., Vanzulli A., Cucchetti A., Vicentin, I, Mosconi, C, Garanzini, E, Sposito, C, Serenari, M, Buscemi, V, Verna, M, Spreafico, C, Golfieri, R, Mazzaferro, V, De Carlis, L, Cescon, M, Ercolani, G, Vanzulli, A, Cucchetti, A, Vicentin I., Mosconi C., Garanzini E., Sposito C., Serenari M., Buscemi V., Verna M., Spreafico C., Golfieri R., Mazzaferro V., De Carlis L., Cescon M., Ercolani G., Vanzulli A., and Cucchetti A.

Abstract

Objectives: To evaluate the inter-observer reliability of modified Response Evaluation Criteria In Solid Tumours (mRECIST) of patients with hepatocellular carcinoma (HCC) undergoing neo-adjuvant treatments before liver transplant (LT). The agreement of tumor number, size, transplant criteria, and the radiological-pathological concordance were also assessed. Methods: A total of 180 radiological studies before/after neo-adjuvant therapies performed on 90 patients prior to LT were reviewed from three expert centers. Kappa-statistic and intraclass correlation (ICC) were evaluated on mRECIST and on tumoral features. Complete radiological response (CR) was compared with complete pathological response (CPR). Results: Before neo-adjuvant therapies, the agreement on tumor number, size, and transplant criteria ranged from moderate (defined as ICC of 0.41–0.60) to almost perfect (ICC of 0.81–0.99), being higher with magnetic resonance imaging (MRI) than CT (0.657–0.899 and 0.422–0.776, respectively). After neo-adjuvant therapies, the agreement decreased, as ICCs ranged between 0.518 and 0.663 with MRI and between 0.508 and 0.677 with CT. Concordant mRECIST pairs were 201 of 270 reviews (76.3%) with a kappa of 0.648 indicating substantial agreement. When the three observers completely agreed on CR, the positive predictive value for CPR was 51.6%. The negative predictive value was 94.2% with a kappa of 0.512 indicating fair agreement between radiology and pathology. Conclusions: mRECIST agreement was substantial among the three observers involved. The agreement on tumor number, size, and transplant criteria ranged from moderate to almost perfect, with the highest ICCs obtained with MRI before neo-adjuvant therapies. Finally, the predictive value of mRECIST in the diagnosis of CPR was only fair. Key Points: • The review of 180 radiological exams of patients with hepatocellular carcinoma before and after neo-adjuvant therapies showed that the concordance among three different rate

Published
2021

21. RARP nerve sparing with 3D reconstruction and stereoscopic augmented reality

Author

Schiavina, R., primary, Piazza, P., additional, Beretta, C., additional, Bianchi, L., additional, Chessa, F., additional, Amirhassankhani, S., additional, Costa, F., additional, Balestrazzi, E., additional, Recenti, D., additional, Tartarini, L., additional, Bortonali, B., additional, Cercenelli, L., additional, Droghetti, M., additional, Mottaran, A., additional, Gaudiano, C., additional, Corcioni, B., additional, Golfieri, R., additional, Marcelli, E., additional, and Brunocilla, E., additional

Published
2022
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22. 3D modeling of renal tumors for planning and guidance of selective clamping and UCS suture

Author

Schiavina, R., primary, Bianchi, L., additional, Cercenelli, L., additional, Bortolani, B., additional, Piazza, P., additional, Boschi, S., additional, Droghetti, M., additional, Mottaran, A., additional, Chessa, F., additional, Ercolino, A., additional, Angiolini, A., additional, Lodi, S., additional, Pissavini, A., additional, Fontanella, L., additional, Spinozzi, L., additional, Melloni, R., additional, Bevilacqua, F., additional, Cangemi, D., additional, Gaudiano, C., additional, Corcioni, B., additional, Golfieri, R., additional, Marcelli, E., additional, and Brunocilla, E., additional

Published
2022
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26. Benign liver lesions 2022: Guideline for clinical practice of Associazione Italiana Studio del Fegato (AISF), Società Italiana di Radiologia Medica e Interventistica (SIRM), Società Italiana di Chirurgia (SIC), Società Italiana di Ultrasonologia in Medicina e Biologia (SIUMB), Associazione Italiana di Chirurgia Epatobilio-Pancreatica (AICEP), Società Italiana Trapianti d'Organo (SITO), Società Italiana di Anatomia Patologica e Citologia Diagnostica (SIAPEC-IAP) – Part II - Solid lesions

Author

Pompili, Maurizio, Ardito, Francesco, Brunetti, E., Cabibbo, G., Calliada, F., Cillo, U., de Sio, I., Golfieri, R., Grova, M., Gruttadauria, S., Guido, M., Iavarone, M., Manciulli, T., Pagano, D., Pettinari, I., Santopaolo, Francesco, Soresi, M., Colli, A., Pompili M. (ORCID:0000-0001-6699-7980), Ardito F. (ORCID:0000-0003-1596-2862), Santopaolo F., Pompili, Maurizio, Ardito, Francesco, Brunetti, E., Cabibbo, G., Calliada, F., Cillo, U., de Sio, I., Golfieri, R., Grova, M., Gruttadauria, S., Guido, M., Iavarone, M., Manciulli, T., Pagano, D., Pettinari, I., Santopaolo, Francesco, Soresi, M., Colli, A., Pompili M. (ORCID:0000-0001-6699-7980), Ardito F. (ORCID:0000-0003-1596-2862), and Santopaolo F.

Abstract

Benign liver lesions are increasingly diagnosed in daily clinical practice due to the growing use of imaging techniques for the study of the abdomen in patients who have non-specific symptoms and do not have an increased risk of hepatic malignancy. They include simple or parasitic hepatic cysts and solid benign tumors which differ widely in terms of prevalence, clinical relevance, symptoms and natural history and often lead to significant clinical problems relating to diagnosis and clinical management. Following the need to have updated guidelines on the management of benign focal liver lesions, the Scientific Societies mainly involved in their management have promoted the drafting of a new dedicated document. This document was drawn up according to the present Italian rules and methodologies necessary to produce clinical, diagnostic, and therapeutic guidelines based on evidence. Here we present the second part of the guideline, concerning the diagnosis and clinical management of hemangioma, focal nodular hyperplasia, and hepatocellular adenoma.

Published
2022

27. Benign liver lesions 2022: Guideline for clinical practice of Associazione Italiana Studio del Fegato (AISF), Società Italiana di Radiologia Medica e Interventistica (SIRM), Società Italiana di Chirurgia (SIC), Società Italiana di Ultrasonologia in Medicina e Biologia (SIUMB), Associazione Italiana di Chirurgia Epatobilio-Pancreatica (AICEP), Società Italiana Trapianti d'Organo (SITO), Società Italiana di Anatomia Patologica e Citologia Diagnostica (SIAPEC-IAP) – Part I – Cystic lesions

Author

Pompili, Maurizio, Ardito, Francesco, Brunetti, E., Cabibbo, G., Calliada, F., Cillo, U., de Sio, I., Golfieri, R., Grova, M., Gruttadauria, S., Guido, M., Iavarone, M., Manciulli, T., Pagano, D., Pettinari, I., Santopaolo, Francesco, Soresi, M., Colli, A., Pompili M. (ORCID:0000-0001-6699-7980), Ardito F. (ORCID:0000-0003-1596-2862), Santopaolo F., Pompili, Maurizio, Ardito, Francesco, Brunetti, E., Cabibbo, G., Calliada, F., Cillo, U., de Sio, I., Golfieri, R., Grova, M., Gruttadauria, S., Guido, M., Iavarone, M., Manciulli, T., Pagano, D., Pettinari, I., Santopaolo, Francesco, Soresi, M., Colli, A., Pompili M. (ORCID:0000-0001-6699-7980), Ardito F. (ORCID:0000-0003-1596-2862), and Santopaolo F.

Abstract

Benign liver lesions are increasingly diagnosed in daily clinical practice due to the growing use of imaging techniques for the study of the abdomen in patients who have non-specific symptoms and do not have an increased risk of hepatic malignancy. They include simple or parasitic cysts and solid benign tumors which differ widely in terms of prevalence, clinical relevance, symptoms and natural history and often lead to significant clinical problems relating to diagnosis and clinical management. Following the need to have updated guidelines on the management of benign focal liver lesions, the Scientific Societies mainly involved in their management have promoted the drafting of a new dedicated document. This document was drawn up according to the present Italian rules and methodologies necessary to produce clinical, diagnostic, and therapeutic guidelines based on evidence. Here we present the first part of the guideline, concerning the characterization of focal hepatic lesions detected by ultrasound, and the diagnosis and clinical management of simple and parasitic hepatic cysts, and of polycystic liver disease.

Published
2022

28. Non-invasive diagnosis of clinically significant portal hypertension and treatment with non-selective beta-blockers: a new paradigm

Author

Dajti, E., primary, Ravaioli, F., additional, Marasco, G., additional, Alemanni, L.V., additional, Colecchia, L., additional, Ferrarese, A., additional, Cusumano, C., additional, Gemini, S., additional, Vestito, A., additional, Renzulli, M., additional, Golfieri, R., additional, Festi, D., additional, and Colecchia, A., additional

Published
2022
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29. Sarcopenia predicts ascitic decompensation and mortality independently of portal hypertension status in patients with advanced chronic liver disease outside the liver transplantation setting

Author

Dajti, E., primary, Renzulli, M., additional, Ravaioli, F., additional, Marasco, G., additional, Milandri, M., additional, Rossini, B., additional, Colecchia, L., additional, Alemanni, L.V., additional, Ferrarese, A., additional, Tamè, M., additional, Vestito, A., additional, Azzaroli, F., additional, Festi, D., additional, Golfieri, R., additional, and Colecchia, A., additional

Published
2022
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31. 3D modeling of renal tumors for planning and guidance of selective clamping and urinary collecting system suture

Author

Schiavina, R., primary, Bianchi, L., additional, Cercenelli, L., additional, Bortolani, B., additional, Piazza, P., additional, Boschi, S., additional, Droghetti, M., additional, Mottaran, A., additional, Chessa, F., additional, Ercolino, A., additional, Angiolini, A., additional, Lodi, S., additional, Pissavini, A., additional, Fontanella, L., additional, Spinozzi, L., additional, Melloni, R., additional, Bevilacqua, F., additional, Cangemi, D., additional, Gaudiano, C., additional, Corcioni, B., additional, Golfieri, R., additional, Marcelli, E., additional, and Brunocilla, E., additional

Published
2022
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33. Sustained oxygenation improvement after first prone positioning is associated with liberation from mechanical ventilation and mortality in critically ill COVID-19 patients: a cohort study

Author

Scaramuzzo G., Gamberini L., Tonetti T., Zani G., Ottaviani I., Mazzoli C. A., Capozzi C., Giampalma E., Bacchi Reggiani M. L., Bertellini E., Castelli A., Cavalli I., Colombo D., Crimaldi F., Damiani F., Fusari M., Gamberini E., Gordini G., Laici C., Lanza M. C., Leo M., Marudi A., Nardi G., Papa R., Potalivo A., Russo E., Taddei S., Consales G., Cappellini I., Ranieri V. M., Volta C. A., Guerin C., Spadaro S., Tartaglione M., Chiarini V., Buldini V., Coniglio C., Moro F., Barbalace C., Citino M., Cilloni N., Giuntoli L., Bellocchio A., Matteo E., Pizzilli G., Siniscalchi A., Tartivita C., Matteo F., Marchio A., Bacchilega I., Bernabe L., Guarino S., Mosconi E., Bissoni L., Viola L., Meconi T., Pavoni V., Pagni A., Pompa Cleta P., Cavagnino M., Malfatto A., Adduci A., Pareschi S., Melegari G., Maccieri J., Marinangeli E., Racca F., Verri M., Falo G., Marangoni E., Boni F., Felloni G., Baccarini F. D., Terzitta M., Maitan S., Becherucci F., Parise M., Masoni F., Imbriani M., Orlandi P., Monetti F., Dalpiaz G., Golfieri R., Ciccarese F., Poerio A., Muratore F., Ferrari F., Mughetti M., Franchini L., Neziri E., Miceli M., Minguzzi M. T., Mellini L., Piciucchi S., Bartolucci M., Scaramuzzo G., Gamberini L., Tonetti T., Zani G., Ottaviani I., Mazzoli C.A., Capozzi C., Giampalma E., Bacchi Reggiani M.L., Bertellini E., Castelli A., Cavalli I., Colombo D., Crimaldi F., Damiani F., Fusari M., Gamberini E., Gordini G., Laici C., Lanza M.C., Leo M., Marudi A., Nardi G., Papa R., Potalivo A., Russo E., Taddei S., Consales G., Cappellini I., Ranieri V.M., Volta C.A., Guerin C., Spadaro S., Tartaglione M., Chiarini V., Buldini V., Coniglio C., Moro F., Barbalace C., Citino M., Cilloni N., Giuntoli L., Bellocchio A., Matteo E., Pizzilli G., Siniscalchi A., Tartivita C., Matteo F., Marchio A., Bacchilega I., Bernabe L., Guarino S., Mosconi E., Bissoni L., Viola L., Meconi T., Pavoni V., Pagni A., Pompa Cleta P., Cavagnino M., Malfatto A., Adduci A., Pareschi S., Melegari G., Maccieri J., Marinangeli E., Racca F., Verri M., Falo G., Marangoni E., Boni F., Felloni G., Baccarini F.D., Terzitta M., Maitan S., Becherucci F., Parise M., Masoni F., Imbriani M., Orlandi P., Monetti F., Dalpiaz G., Golfieri R., Ciccarese F., Poerio A., Muratore F., Ferrari F., Mughetti M., Franchini L., Neziri E., Miceli M., Minguzzi M.T., Mellini L., Piciucchi S., and Bartolucci M.

Subjects
medicine.medical_specialty, Supine position, COVID19, medicine.medical_treatment, Respiratory physiology, Prone positioning, ventilatory free days, Critical Care and Intensive Care Medicine, ICU, COVID19, Prone positioning, ventilatory free days, NO, 03 medical and health sciences, 0302 clinical medicine, Anesthesiology, medicine, 030212 general & internal medicine, Mechanical ventilation, business.industry, RC86-88.9, Research, Medical emergencies. Critical care. Intensive care. First aid, Oxygenation, respiratory system, respiratory tract diseases, Prone position, 030228 respiratory system, Anesthesia, ICU, Complication, business, Cohort study
Abstract

Background Prone positioning (PP) has been used to improve oxygenation in patients affected by the SARS-CoV-2 disease (COVID-19). Several mechanisms, including lung recruitment and better lung ventilation/perfusion matching, make a relevant rational for using PP. However, not all patients maintain the oxygenation improvement after returning to supine position. Nevertheless, no evidence exists that a sustained oxygenation response after PP is associated to outcome in mechanically ventilated COVID-19 patients. We analyzed data from 191 patients affected by COVID-19-related acute respiratory distress syndrome undergoing PP for clinical reasons. Clinical history, severity scores and respiratory mechanics were analyzed. Patients were classified as responders (≥ median PaO2/FiO2 variation) or non-responders (2/FiO2 variation) based on the PaO2/FiO2 percentage change between pre-proning and 1 to 3 h after re-supination in the first prone positioning session. Differences among the groups in physiological variables, complication rates and outcome were evaluated. A competing risk regression analysis was conducted to evaluate if PaO2/FiO2 response after the first pronation cycle was associated to liberation from mechanical ventilation. Results The median PaO2/FiO2 variation after the first PP cycle was 49 [19–100%] and no differences were found in demographics, comorbidities, ventilatory treatment and PaO2/FiO2 before PP between responders (96/191) and non-responders (95/191). Despite no differences in ICU length of stay, non-responders had a higher rate of tracheostomy (70.5% vs 47.9, P = 0.008) and mortality (53.7% vs 33.3%, P = 0.006), as compared to responders. Moreover, oxygenation response after the first PP was independently associated to liberation from mechanical ventilation at 28 days and was increasingly higher being higher the oxygenation response to PP. Conclusions Sustained oxygenation improvement after first PP session is independently associated to improved survival and reduced duration of mechanical ventilation in critically ill COVID-19 patients.

Published
2021

34. Clinical Application of Trans-Arterial Radioembolization in Hepatic Malignancies in Europe: First Results from the Prospective Multicentre Observational Study CIRSE Registry for SIR-Spheres Therapy (CIRT)

Author

Helmberger T., Golfieri R., Pech M., Pfammatter T., Arnold D., Cianni R., Maleux G., Munneke G., Pellerin O., Peynircioglu B., Sangro B., Schaefer N., de Jong N., Bilbao J. I., Pelage J. -P., Manas D. M., Kolligs F. T., Ezziddin S., Peters R., Albrecht T., D'Archambeau O., Balli T., Bilgic S., Bloom A., Cioni R., Fischbach R., Flamen P., Gerard L., Grozinger G., Katoh M., Koehler M., Kroger J. R., Kuhl C., Orsi F., Ozgun M., Reimer P., Ronot M., Schmid A., Vit A., Helmberger T., Golfieri R., Pech M., Pfammatter T., Arnold D., Cianni R., Maleux G., Munneke G., Pellerin O., Peynircioglu B., Sangro B., Schaefer N., de Jong N., Bilbao J.I., Pelage J.-P., Manas D.M., Kolligs F.T., Ezziddin S., Peters R., Albrecht T., D'Archambeau O., Balli T., Bilgic S., Bloom A., Cioni R., Fischbach R., Flamen P., Gerard L., Grozinger G., Katoh M., Koehler M., Kroger J.R., Kuhl C., Orsi F., Ozgun M., Reimer P., Ronot M., Schmid A., Vit A., University of Zurich, On behalf of the CIRT Steering Committee, On behalf of the CIRT Principal Investigators, Pelage, J.P., Manas, D.M., Kolligs, F.T., Ezziddin, S., Peters, R., Albrecht, T., D'Archambeau, O., Balli, T., Bilgic, S., Bloom, A., Cioni, R., Fischbach, R., Flamen, P., Gerard, L., Grözinger, G., Katoh, M., Koehler, M., Kröger, J.R., Kuhl, C., Orsi, F., Ozgun, M., Reimer, P., Ronot, M., Schmid, A., and Vit, A.

Subjects
Male, Registrie, SIR-Spheres, Yttrium-90, Cardiac & Cardiovascular Systems, Tare weight, Colorectal cancer, Hepatocellular carcinoma, medicine.medical_treatment, Metastasi, Radioisotope brachytherapy, COLORECTAL-CANCER, Metastasis, 030218 nuclear medicine & medical imaging, 0302 clinical medicine, Observational study, Medicine, Yttrium Radioisotopes, Prospective Studies, Registries, SALVAGE THERAPY, Y-90 RADIOEMBOLIZATION, 10042 Clinic for Diagnostic and Interventional Radiology, Incidence, Mortality rate, Radiology, Nuclear Medicine & Medical Imaging, Liver Neoplasms, CANCER LIVER METASTASES, Middle Aged, Embolization, Therapeutic, Microspheres, Europe, Trans-arterial radioembolization, Liver, SAFETY, 030220 oncology & carcinogenesis, Female, Cardiology and Cardiovascular Medicine, Life Sciences & Biomedicine, medicine.medical_specialty, Carcinoma, Hepatocellular, 610 Medicine & health, Context (language use), Therapeutic embolization, 03 medical and health sciences, Breast cancer, GLASS MICROSPHERES, ADVANCED HEPATOCELLULAR-CARCINOMA, Pancreatic cancer, Internal medicine, INTRAHEPATIC CHOLANGIOCARCINOMA, Humans, Radiology, Nuclear Medicine and imaging, Clinical Investigation, Retrospective Studies, Science & Technology, INTERNAL RADIATION-THERAPY, business.industry, EFFICACY, medicine.disease, Radiography, Cardiovascular System & Cardiology, business
Abstract

Purpose To address the lack of prospective data on the real-life clinical application of trans-arterial radioembolization (TARE) in Europe, the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) initiated the prospective observational study CIRSE Registry for SIR-Spheres® Therapy (CIRT). Materials and Methods Patients were enrolled from 1 January 2015 till 31 December 2017. Eligible patients were adult patients treated with TARE with Y90 resin microspheres for primary or metastatic liver tumours. Patients were followed up for 24 months after treatment, whereas data on the clinical context of TARE, overall survival (OS) and safety were collected. Results Totally, 1027 patients were analysed. 68.2% of the intention of treatment was palliative. Up to half of the patients received systemic therapy and/or locoregional treatments prior to TARE (53.1%; 38.3%). Median overall survival (OS) was reported per cohort and was 16.5 months (95% confidence interval (CI) 14.2–19.3) for hepatocellular carcinoma, 14.6 months (95% CI 10.9–17.9) for intrahepatic cholangiocarcinoma. For liver metastases, median OS for colorectal cancer was 9.8 months (95% CI 8.3–12.9), 5.6 months for pancreatic cancer (95% CI 4.1–6.6), 10.6 months (95% CI 7.3–14.4) for breast cancer, 14.6 months (95% CI 7.3–21.4) for melanoma and 33.1 months (95% CI 22.1–nr) for neuroendocrine tumours. Statistically significant prognostic factors in terms of OS include the presence of ascites, cirrhosis, extra-hepatic disease, patient performance status (Eastern Cooperative Oncology Group), number of chemotherapy lines prior to TARE and tumour burden. Thirty-day mortality rate was 1.0%. 2.5% experienced adverse events grade 3 or 4 within 30 days after TARE. Conclusion In the real-life clinical setting, TARE is largely considered to be a part of a palliative treatment strategy across indications and provides an excellent safety profile. Level of evidence Level 3. Trial registration ClinicalTrials.gov NCT02305459.

Published
2021

36. Augmented reality to guide intraoperative frozen section during robot-assisted radical prostatectomy

Author

Bianchi, L., primary, Schiavina, R., additional, Chessa, F., additional, Angiolini, A., additional, Cercenelli, L., additional, Lodi, S., additional, Bortolani, B., additional, Molinaroli, E., additional, Ercolino, A., additional, Casablanca, C., additional, Farneti, F., additional, Gaudiano, C., additional, Mottaran, A., additional, Porreca, A., additional, Golfieri, R., additional, Romagnoli, D., additional, Giunchi, F., additional, Fiorentino, M., additional, Puliatti, S., additional, Mottrie, A., additional, Diciotti, S., additional, Marcelli, E., additional, and Brunocilla, E., additional

Published
2021
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37. Head-to-head comparison of prostate cancer detection rate at MRI-targeted FUSION biopsy between hub and spoke mpMRI Italian centers

Author

Bianchi, L., primary, Droghetti, M., additional, Lando, G., additional, Roveroni, C., additional, Salvador, M., additional, Beretta, C., additional, Balestrazzi, E., additional, Feruzzi, A., additional, Milani, G., additional, Chessa, F., additional, Ercolino, A., additional, Farneti, F., additional, Rustici, A., additional, De Cinque, A., additional, Gaudiano, C., additional, Corcioni, B., additional, Golfieri, R., additional, Schiavina, R., additional, and Brunocilla, E., additional

Published
2021
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38. Percutaneous tumor ablation compared to partial nephrectomy for cT1a renal cancer: the impact of histologic variant

Author

Bianchi, L., primary, Chessa, F., additional, Casablanca, C., additional, Piazza, P., additional, Mottaran, A., additional, Droghetti, M., additional, Roveroni, C., additional, Balestrazzi, E., additional, Ercolino, A., additional, Farneti, F., additional, Gaudiano, C., additional, Cappelli, A., additional, Modestino, F., additional, Bertaccini, A., additional, Marcelli, E., additional, Porreca, A., additional, De Concilio, B., additional, Golfieri, R., additional, Serra, C., additional, Celia, A., additional, Schiavina, R., additional, and Brunocilla, E., additional

Published
2021
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40. 3D virtual renal modeling to improve the learning curve of percutaneous nephrolithotripsy

Author

Molinaroli, E., primary, Giampaoli, M., additional, Pultrone, C.V., additional, Bianchi, L., additional, Angiolini, A., additional, Cercenelli, L., additional, Bortolani, B., additional, Mottaran, A., additional, Recenti, D., additional, Chessa, F., additional, Gaudiano, C., additional, Golfieri, R., additional, Marcelli, E., additional, Schiavina, R., additional, and Brunocilla, E., additional

Published
2021
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41. Percutaneous tumor ablation compared to partial nephrectomy for cT1a renal cancer: the impact of histologic variant

Author

Mottaran, A., primary, Bianchi, L., additional, Casablanca, C., additional, Piazza, P., additional, Chessa, F., additional, Droghetti, M., additional, Roveroni, C., additional, Balestrazzi, E., additional, Gaudiano, C., additional, Cappelli, A., additional, Modestino, F., additional, Bertaccini, A., additional, Marcelli, E., additional, Porreca, A., additional, De Concilio, B., additional, Golfieri, R., additional, Serra, C., additional, Celia, A., additional, Schiavina, R., additional, and Brunocilla, E., additional

Published
2021
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42. Novel volumetric and morphologic parameters derived from 3D virtual modelling to improve comprehension of tumor’s anatomy in patients with renal cancer

Author

Bianchi, L., primary, Bortolani, B., additional, Mottaran, A., additional, Cercenelli, L., additional, Boschi, S., additional, Droghetti, M., additional, Molinaroli, E., additional, Chessa, F., additional, Balestrazzi, E., additional, Gaudiano, C., additional, Rustici, A., additional, Cappelli, A., additional, Golfieri, R., additional, Marcelli, E., additional, Schiavina, R., additional, and Brunocilla, E., additional

Published
2021
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43. Site-specific concordance of targeted and systematic biopsy cores: can we spare the double-tap?

Author

Chessa, F., primary, Droghetti, M., additional, Bianchi, L., additional, Beretta, C., additional, Ercolino, A., additional, Salvador, M., additional, Casablanca, C., additional, Di Fresco, S., additional, Roveroni, C., additional, Balestrazzi, E., additional, Feruzzi, A., additional, Costa, F., additional, Cacciapuoti, C., additional, Rustici, A., additional, De Cinque, A., additional, Gaudiano, C., additional, Corcioni, B., additional, Golfieri, R., additional, Schiavina, R., additional, and Brunocilla, E., additional

Published
2021
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44. Augmented reality to guide intraoperative frozen section during robot-assisted radical prostatectomy

Author

Schiavina, R., primary, Bianchi, L., additional, Angiolini, A., additional, Chessa, F., additional, Cercenelli, L., additional, Bortolani, B., additional, Molinaroli, E., additional, Casablanca, C., additional, Gaudiano, C., additional, Mottaran, A., additional, Porreca, A., additional, Golfieri, R., additional, Romagnoli, D., additional, Giuchi, F., additional, Fiorentino, M., additional, Puliatti, S., additional, Mottrie, A., additional, Diciotti, S., additional, Marcelli, E., additional, and Brunocilla, E., additional

Published
2021
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45. Three-dimensional virtual modelling for anatomical comprehension of renal anatomy: validation of CSA, RENAL, PADUA, ABC scores before robot-assisted partial nephrectomy

Author

Mottaran, A., primary, Bianchi, L., additional, Schiavina, R., additional, Bortolani, B., additional, Cercenelli, L., additional, Chessa, F., additional, Droghetti, M., additional, Boschi, S., additional, Gaudiano, C., additional, Rustici, A., additional, Salvador, M., additional, Bertaccini, A., additional, Golfieri, R., additional, Marcelli, E., additional, and Brunocilla, E., additional

Published
2021
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47. 1355P Monitoring tumor growth rate to predict immune checkpoint inhibitors’ treatment outcome in advanced NSCLC

Author

Dall'Olio, F.G., primary, Parisi, C., additional, Marcolin, L., additional, Brocchi, S., additional, Caramella, C., additional, Conci, N., additional, Carpani, G., additional, Gelsomino, F., additional, Ardizzoni, S., additional, Marchese, P.V., additional, Paccapelo, A., additional, Grilli, G., additional, Golfieri, R., additional, Besse, B., additional, and Ardizzoni, A., additional

Published
2021
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48. PO-1239 99mTc-macroaggregated albumin SPECT/CT in HCC treated with Selective Internal Radiation Therapy

Author

Lodi Rizzini, E., primary, Laghi, V., additional, Cavallini, L., additional, Deraco, E., additional, Vallerossa, D., additional, Scampoli, C., additional, Bellarosa, C., additional, Cammelli, S., additional, Strolin, S., additional, Strigari, L., additional, Golfieri, R., additional, Fanti, S., additional, Frezza, G.P., additional, Morganti, A.G., additional, and Monari, F., additional

Published
2021
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49. OC-0413 Definition Of LOcal REcurrence Site in resected pancreatic cancer: a multicentric study (DOLORES-1)

Author

Arcelli, A., primary, Bertini, F., additional, Strolin, S., additional, Macchia, G., additional, Deodato, F., additional, Cilla, S., additional, Parisi, S., additional, Sainato, A., additional, Fiore, M., additional, Gabriele, P., additional, Genovesi, D., additional, Cellini, F., additional, Guido, A., additional, Cammelli, S., additional, Buwenge, M., additional, Loi, E., additional, Renzulli, M., additional, Golfieri, R., additional, Morganti, A.G., additional, and Strigari, L., additional

Published
2021
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50. P181 - Proposal and internal validation of a nomogram for the prediction of local recurrence-free survival after percutaneous ablation for ct1 renal masses

Author

Mottaran, A., Nocera, L., Bianchi, L., Luzzago, S., Bandini, M., Piazza, P., Celia, A., Serra, C., Cappelli, A., De Cinque, A., Modestino, F., Golfieri, R., Musi, G., Gallina, A., De Cobelli, F., Mauri, G., Orsi, F., Capitanio, U., Schiavina, R., De Cobelli, O., Montorsi, F., and Brunocilla, E.

Published
2023
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