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Introduction: Diabetes mellitus is one of the most important metabolic disorders worldwide. Today numerous medicinal plants have been used for the management of diabetes mellitus. The aim of this study was to assess the effect of Echium amoenum (EA) hydroalcoholic extract on blood glucose and weight in diabetic rats. Materials and Methods: In this study, 30 male Wistar rats, were randomly divided to five groups with six rats per group: control diabetic diabetic rats treated with hydroalcoholic extract of EA (100, 400 and 600 mg/kg). Diabetes was induced in the rats by administrating a single dose of Streptozotocin (60 mg/kg, ip). Blood sugar and animal’s weight were measured on day 0 (baseline), 10, 20 and 30 day after baselines. Finally, insulin and activities of superoxide dismutase enzyme (SOD) levels were determined. Results: In all groups treated with extract the mean of weight was significantly increased compared whit diabetic group (P